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Methotrexate Respiratory Failure Side Effects

Methotrexate Respiratory Failure Side Effect Reports


The following Methotrexate Respiratory Failure side effect reports were submitted by healthcare professionals and consumers.

This information will help you understand how side effects, such as Respiratory Failure, can occur, and what you can do about them.

A side effect could appear soon after you start Methotrexate or it might take time to develop.



Pneumonitis, Respiratory Failure

This Respiratory Failure side effect was reported by a pharmacist from GB. A 68-year-old female patient (weight:NA) experienced the following symptoms/conditions: rheumatoid arthritis. The patient was prescribed Methotrexate Sodium (dosage: Unk), which was started on Aug 16, 2013. Concurrently used drugs:
  • Sulfasalazine (Unk)
  • Leflunomide (20 Mg, Unk)
  • Aspirin (Unk)
  • Atorvastatin (Unk)
  • Bendrofluazide (Unk)
  • Folic Acid (Unk)
  • Furosemide (Unk)
  • Lansoprazole (Unk)
When starting to take Methotrexate Sodium the consumer reported the following symptoms:
  • Pneumonitis
  • Respiratory Failure
These side effects may potentially be related to Methotrexate Sodium.
Cardiovascular Insufficiency, Cardiac Arrest, Respiratory Failure, Dyspnoea, Face Oedema, C-reactive Protein Increased, Leukopenia, Thrombocytopenia

This Respiratory Failure Methotrexate side effect was reported by a health professional from PL on Mar 03, 2014. A male , 49 years of age, was treated with Methotrexate. The patient presented the following health conditions:
  • Cardiovascular Insufficiency
  • Cardiac Arrest
  • Respiratory Failure
  • Dyspnoea
  • Face Oedema
  • C-reactive Protein Increased
  • Leukopenia
  • Thrombocytopenia
. Methotrexate dosage: 1 Df, Qd. Additional drugs used at the same time: NA. The patient was hospitalized.
Foaming At Mouth, Dyskinesia, Status Epilepticus, Respiratory Failure, Convulsion, Hemiparesis, Oedema, Cerebral Haemorrhage, Leukaemia

This is a Methotrexate side effect report of a 10-year-old patient (weight:NA) from US, suffering from the following symptoms/conditions: NA, who was treated with Methotrexate (dosage:NA, start time: NS), combined with:
  • Peg-l-asparaginase (k-h)
, and developed a serious reaction and a Respiratory Failure side effect. The patient presented with:
  • Foaming At Mouth
  • Dyskinesia
  • Status Epilepticus
  • Respiratory Failure
  • Convulsion
  • Hemiparesis
  • Oedema
  • Cerebral Haemorrhage
  • Leukaemia
which developed after the beginning of treatment. The patient was hospitalized. This side effect report can indicate a possible existence of increased vulnerability to Methotrexate treatment in patients suffering from NA, resulting in Respiratory Failure.

Respiratory Failure, Interstitial Lung Disease, Cardiac Failure, Pyrexia, Jugular Vein Distension, C-reactive Protein Increased

A 64-year-old patient (weight: NA) from COUNTRY NOT SPECIFIED with the following symptoms: psoriasis started Methotrexate treatment (dosage: NA) on NS. Soon after starting Methotrexate treatment, the consumer experienced several side effects, including:
  • Respiratory Failure
  • Interstitial Lung Disease
  • Cardiac Failure
  • Pyrexia
  • Jugular Vein Distension
  • C-reactive Protein Increased
. Concurrently used drugs:
  • Infliximab
  • Cyclosporine
The patient was hospitalized. This finding indicates that some patients can be more vulnerable to developing Methotrexate side effects, such as Respiratory Failure.
Pulmonary Toxicity, Respiratory Failure, Pneumonitis

A female patient from COUNTRY NOT SPECIFIED was prescribed and started Methotrexate on Dec 19, 2013. Patient felt the following Methotrexate side effects: pulmonary toxicity, respiratory failure, pneumonitis Additional patient health information: Female , 64 years of age, The consumer reported the following symptoms: was diagnosed with and. Methotrexate dosage: NA. Concurrently used drugs: NA. The patient was hospitalized.
Multi-organ Failure, Toxicity To Various Agents, Respiratory Failure, Renal Failure Acute, Septic Shock, Mucosal Inflammation, Pruritus, Abdominal Pain

This report suggests a potential Methotrexate Respiratory Failure side effect(s) that can have serious consequences. A 75-year-old female patient from IL (weight:NA) was diagnosed with the following health condition(s): rheumatoid arthritis and used Methotrexate (dosage: NA) starting NS. Soon after starting Methotrexate the patient began experiencing various side effects, including:
  • Multi-organ Failure
  • Toxicity To Various Agents
  • Respiratory Failure
  • Renal Failure Acute
  • Septic Shock
  • Mucosal Inflammation
  • Pruritus
  • Abdominal Pain
Drugs used concurrently:NA. Although Methotrexate demonstrated significant improvements in a number of clinically relevant cases, troublesome symptoms, such as Respiratory Failure, may still occur.
Multi-organ Failure, Terminal State, Septic Shock, Respiratory Failure, Renal Failure Acute, Mucosal Inflammation, Abdominal Pain, Platelet Count Decreased, White Blood Cell Count Decreased

An adverse event was reported by a health professional on Oct 08, 2013 by a Female taking Methotrexate (dosage: 10 Mg, Qd Instead Of A Weekly Dose) was diagnosed with and. Location: IL , 75 years of age, patient began experiencing various side effects, including: Directly after treatment started, patient experienced the unwanted or unexpected Methotrexate side effects: multi-organ failure, terminal state, septic shock, respiratory failure, renal failure acute, mucosal inflammation, abdominal pain, platelet count decreased, white blood cell count decreased. Additional medications/treatments:
Toxicity To Various Agents, Respiratory Failure, Renal Failure Acute, Septic Shock, Multi-organ Failure, Pruritus, Mucosal Inflammation, Abdominal Pain

This Respiratory Failure problem was reported by a health professional from IL. A 75-year-old female patient (weight: NA) was diagnosed with the following medical condition(s): rheumatoid arthritis.On NS a consumer started treatment with Methotrexate (dosage: NA). The following drugs/medications were being taken at the same time: NA. When commencing Methotrexate, the patient experienced the following unwanted symptoms /side effects:
  • Toxicity To Various Agents
  • Respiratory Failure
  • Renal Failure Acute
  • Septic Shock
  • Multi-organ Failure
  • Pruritus
  • Mucosal Inflammation
  • Abdominal Pain
Although all drugs are carefully tested before they are licensed for use, they carry potential side effect risks. Some side effects, such as Respiratory Failure, may become evident only after a product is in use by the general population.
Pulmonary Veno-occlusive Disease, Cytomegalovirus Infection, Mucosal Inflammation, Sepsis, Pulmonary Haemorrhage, Pneumonitis, Pulmonary Hypertension, Respiratory Failure, Idiopathic Pneumonia Syndrome

This is a Methotrexate side effect report of a 8-year-old female patient (weight: NA) from GB. The patient developed the following symptoms/conditions: prophylaxis against graft versus host disease and was treated with Methotrexate (dosage: NA) starting NS. Concurrently used drugs:
  • Ciclosporin
  • Busulfan (14 Mg/kg, Unk)
  • Cyclophosphamide (200 Mg/kg, Unk)
  • Alemtuzumab (0.3 Mg/kg, Unk)
Soon after that, the consumer experienced the following of symptoms:
  • Pulmonary Veno-occlusive Disease
  • Cytomegalovirus Infection
  • Mucosal Inflammation
  • Sepsis
  • Pulmonary Haemorrhage
  • Pneumonitis
  • Pulmonary Hypertension
  • Respiratory Failure
  • Idiopathic Pneumonia Syndrome
This opens a possibility that Methotrexate could cause Respiratory Failure and that some female patients may be more susceptible.
Pneumonia, Respiratory Failure, Interstitial Lung Disease, Pulmonary Toxicity

This Respiratory Failure side effect was reported by a consumer or non-health professional from US on Jun 18, 2013. A female patient from US , 64 years of age, was diagnosed with and was treated with Methotrexate. Directly after treatment started, patient experienced the unwanted or unexpected Methotrexate side effects: pneumonia, respiratory failure, interstitial lung disease, pulmonary toxicity. Methotrexate dosage: (8tabs/1x/wk).
Associated medications used:
  • Prednisone
  • Folic Acid
The patient was hospitalized. These side effects may potentially be related to Methotrexate.
Pulmonary Mycosis, Febrile Neutropenia, Respiratory Failure, Pleural Effusion, Platelet Count Decreased

This Respiratory Failure side effect was reported by a physician from BR. A 17-year-old patient (weight:NA) experienced the following symptoms/conditions: burkitt^s lymphoma. The patient was prescribed Methotrexate (dosage: NA), which was started on NS. Concurrently used drugs:
  • Cyclophosphamide
  • Vincristine
  • Ifosfamide
  • Carboplatin
  • Etoposide
  • Doxorubicin
  • Prednisone
When starting to take Methotrexate the consumer reported the following symptoms:
  • Pulmonary Mycosis
  • Febrile Neutropenia
  • Respiratory Failure
  • Pleural Effusion
  • Platelet Count Decreased
The patient was hospitalized. These side effects may potentially be related to Methotrexate.
Pericardial Effusion, Cardiac Tamponade, Shock, Respiratory Failure, Pleural Effusion

This Respiratory Failure Methotrexate side effect was reported by a health professional from COUNTRY NOT SPECIFIED on Apr 18, 2013. A Female , 38 years of age, was diagnosed with and was treated with Methotrexate. The patient presented the following health conditions:
  • Pericardial Effusion
  • Cardiac Tamponade
  • Shock
  • Respiratory Failure
  • Pleural Effusion
. Methotrexate dosage: NA. Additional drugs used at the same time:
  • Cyclophosphamide Tablets Usp
  • Cyclosporine
  • Trimethoprim-sufamethoxazole
Encephalitis, Intracranial Pressure Increased, Respiratory Failure, Varicella, Varicella Zoster Pneumonia

This is a Methotrexate side effect report of a 7.-year-old patient (weight:NA) from COUNTRY NOT SPECIFIED, suffering from the following symptoms/conditions: uveitis, who was treated with Methotrexate (dosage:7.5 Mg, Qw, start time: Oct 08, 2010), combined with:
  • Remicade (125 Mg, Unk)
  • Prednisolone
  • Mydriacyl (2 Df, Tid)
  • Cosopt (2 Df, Bid)
  • Xalatan (2 Df, Qd)
, and developed a serious reaction and a Respiratory Failure side effect. The patient presented with:
  • Encephalitis
  • Intracranial Pressure Increased
  • Respiratory Failure
  • Varicella
  • Varicella Zoster Pneumonia
which developed after the beginning of treatment. The patient was hospitalized. This side effect report can indicate a possible existence of increased vulnerability to Methotrexate treatment in patients suffering from uveitis, resulting in Respiratory Failure.
Neutropenia, Acute Respiratory Distress Syndrome, Immune Reconstitution Inflammatory Syndrome, Pneumocystis Jirovecii Pneumonia, Marrow Hyperplasia, Respiratory Failure

A 51-year-old female patient (weight: NA) from US with the following symptoms: rheumatoid arthritis started Methotrexate treatment (dosage: NA) on NS. Soon after starting Methotrexate treatment, the consumer experienced several side effects, including:
  • Neutropenia
  • Acute Respiratory Distress Syndrome
  • Immune Reconstitution Inflammatory Syndrome
  • Pneumocystis Jirovecii Pneumonia
  • Marrow Hyperplasia
  • Respiratory Failure
. Concurrently used drugs:
  • Prednisone
The patient was hospitalized. This finding indicates that some patients can be more vulnerable to developing Methotrexate side effects, such as Respiratory Failure.
Respiratory Failure

A patient from US was prescribed and started Methotrexate on Feb 13, 2013. After Methotrexate was administered, patient encountered several Methotrexate side effects: respiratory failure Additional patient health information: male , 57 years of age, weighting 227.5 lb, The consumer reported the following symptoms: was diagnosed with and. Methotrexate dosage: 6 Tablets 15 Mg Weekle. Concurrently used drugs: NA. The patient was hospitalized.
Immune Reconstitution Inflammatory Syndrome, Pneumocystis Jirovecii Pneumonia, Respiratory Failure, Acute Respiratory Distress Syndrome, Neutropenia

This report suggests a potential Methotrexate Respiratory Failure side effect(s) that can have serious consequences. A 51-year-old female patient from COUNTRY NOT SPECIFIED (weight:NA) was diagnosed with the following health condition(s): juvenile idiopathic arthritis and used Methotrexate (dosage: NA) starting NS. Soon after starting Methotrexate the patient began experiencing various side effects, including:
  • Immune Reconstitution Inflammatory Syndrome
  • Pneumocystis Jirovecii Pneumonia
  • Respiratory Failure
  • Acute Respiratory Distress Syndrome
  • Neutropenia
Drugs used concurrently:
  • Prednisone (5 Mg)
  • Filgrastim
The patient was hospitalized. Although Methotrexate demonstrated significant improvements in a number of clinically relevant cases, troublesome symptoms, such as Respiratory Failure, may still occur.
Respiratory Failure, Pneumonia Viral, Bk Virus Infection, Dyspnoea, Viral Haemorrhagic Cystitis, Urinary Tract Obstruction, Haemorrhage Urinary Tract, Renal Impairment, Haematuria

An adverse event was reported by a health professional on Jan 11, 2013 by a male taking Methotrexate (dosage: NA) was diagnosed with and. Location: JP , 39 years of age, patient began experiencing various side effects, including: Patient felt the following Methotrexate side effects: respiratory failure, pneumonia viral, bk virus infection, dyspnoea, viral haemorrhagic cystitis, urinary tract obstruction, haemorrhage urinary tract, renal impairment, haematuria. Additional medications/treatments:
Multiple prescriptions taken:
  • Methylprednisolone (1 Mg/kg, Unk)
  • Methylprednisolone (5-80 Mg, Unk)
  • Ciprofloxacin
  • Aciclovir
  • Fluconazole
  • Immunoglobulins
  • Granulocyte Stimulating Factors
  • Cidofovir (5 Mg/kg, Unk)
The patient was hospitalized.
Pneumonia, Septic Shock, Fatigue, Dyspnoea, Pyrexia, Respiratory Failure

This Respiratory Failure problem was reported by a physician from TH. A 68-year-old female patient (weight: NA) was diagnosed with the following medical condition(s): rheumatoid arthritis.On Mar 21, 2008 a consumer started treatment with Methotrexate (dosage: 1.0714 Milligram Daily;). The following drugs/medications were being taken at the same time: NA. When commencing Methotrexate, the patient experienced the following unwanted symptoms /side effects:
  • Pneumonia
  • Septic Shock
  • Fatigue
  • Dyspnoea
  • Pyrexia
  • Respiratory Failure
The patient was hospitalized. Although all drugs are carefully tested before they are licensed for use, they carry potential side effect risks. Some side effects, such as Respiratory Failure, may become evident only after a product is in use by the general population.
Respiratory Failure, Sepsis, Hypotension, Pancytopenia, Intestinal Haemorrhage

This is a Methotrexate side effect report of a 89-year-old female patient (weight: NA) from COUNTRY NOT SPECIFIED. The patient developed the following symptoms/conditions: NA and was treated with Methotrexate (dosage: 7.5 Mg) starting NS. Concurrently used drugs:
  • Leucovorin Calcium
  • Dopamine
  • G-csf
  • Bicarbonate
Soon after that, the consumer experienced the following of symptoms:
  • Respiratory Failure
  • Sepsis
  • Hypotension
  • Pancytopenia
  • Intestinal Haemorrhage
The patient was hospitalized. This opens a possibility that Methotrexate could cause Respiratory Failure and that some female patients may be more susceptible.
Uterine Cancer, Respiratory Failure

This Respiratory Failure side effect was reported by a physician from SE on Dec 11, 2013. A female patient from SE , 74 years of age, was diagnosed with and was treated with Methotrexate. Patient felt the following Methotrexate side effects: uterine cancer, respiratory failure. Methotrexate dosage: NA. The patient was hospitalized. These side effects may potentially be related to Methotrexate.
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DISCLAIMER: ALL DATA PROVIDED AS-IS, refer to terms of use for additional information.

Methotrexate Respiratory Failure Causes and Reviews


Respiratory failure happens when not enough oxygen passes from your lungs into your blood. Your body's organs, such as your heart and brain, need oxygen-rich blood to work well. Respiratory failure also can happen if your lungs can't remove carbon dioxide (a waste gas) from your blood. Too much carbon dioxide in your blood can harm your body's organs.

Diseases and conditions that affect your breathing can cause respiratory failure. Examples include

  • Lung diseases such as COPD (chronic obstructive pulmonary disease), pneumonia, pulmonary embolism, and cystic fibrosis
  • Conditions that affect the nerves and muscles that control breathing, such as spinal cord injuries, muscular dystrophy and stroke
  • Damage to the tissues and ribs around the lungs. An injury to the chest can cause this damage.
  • Drug or alcohol overdose
  • Injuries from inhaling smoke or harmful fumes

Treatment for respiratory failure depends on whether the condition is acute (short-term) or chronic (ongoing) and how severe it is. It also depends on the underlying cause. You may receive oxygen therapy and other treatment to help you breathe.

NIH: National Heart, Lung, and Blood Institute


Methotrexate Respiratory Failure Reviews

Mon, 21 Feb 2011

My 27 years of MTX therapy have prevented physical deformity but caused me to have damage to my lungs. I am short of breath on any activity. MTX helped the pain somewhat but at the cost of my lungs? I was never told about this possibility nor told it ultimately RA could be fatal. I am only in my 50's not ready to die yet!

Sat, 26 Oct 2013

has anybody had any positive affects from taking " Methoblastin " (Methotrexate) for psoaratic arthritis ? these reviews sound terrible and i have been told to go on it... im a little scared now :(

Sun, 15 May 2011

I have been on Methotrexate for almost months and last two weeks have had severe pains at times lower back , It feel like the kidneys because one side hurts at times and in the mornings it is worse. I am 3 days shy of talking another blood test. Is there anything I can do other than drink a lot of water. Thank you

Sat, 20 Dec 2008
Hi I haven't had any side effects for the past six years of Methotrexate. but recently I am having some stomach discomfort like as soon as i eat something i have the slight discomfort on my abdoman. I take a glass of green leaf juice and i am fine again. I would want to know if I should reduce the dose.
Sun, 24 Jan 2010
I just started Methotrexate, I started itching in the same areas where I had experienced itching with the chicken pox 2 years ago. I am a 51 year old female who contracted chicken pox at 49 years old. This frightens me as I know this can cause disseminated herpes which can be potentially fatal. My Rheum told me to take Benadryl. I believe this is going to be my one and only shot this drug scares the death out of me.
Tue, 27 Apr 2010
painful cough after 2 days of 1st dose lasting-- to date-- 6 days
Thu, 27 May 2010
I am 60 Years of age. 8 years ago i was falsely diagnosed with Rheumatoid Arthritis, i was started on Methoblastin 5Mg a week, Was not given Folic Acid and Ranitidine within the 5 months of taking the tablets i developed exposed blood vessels and spots, Stomach pains, reflux, Unable to properly swollow food, confussion, memmory loss, anxiety attacks, nightmares, hard on sleeping, high fevers, diahria, halusanations, itching, dry skin, mouth and eyes, coughin, sore tendons etc.. After i had stoped taking it, specialist said the side effects would go away. The side effects have never gone.. I try to controll it by taking Folic Acid 1mg a day, Glusamine (Joint food). 3 days a week i will take a small amount of Milk Thistle. Too much of Milk thistle would cause Mood swings and Constipation. Doctors are no help.
Sat, 18 Sep 2010
im a 44yrs old female who took Methotrexate for 2yrs with excellent results and no side effects but had to stop taking it when it started lowering my white cells.
DISCLAIMER: ALL DATA PROVIDED AS-IS, refer to terms of use for additional information.

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Hypertension (115)
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Nasopharyngitis (93)
Paraesthesia (93)
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