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Methotrexate Rheumatoid Arthritis Side Effects

Methotrexate Rheumatoid Arthritis Side Effect Reports


The following Methotrexate Rheumatoid Arthritis side effect reports were submitted by healthcare professionals and consumers.

This information will help you understand how side effects, such as Rheumatoid Arthritis, can occur, and what you can do about them.

A side effect could appear soon after you start Methotrexate or it might take time to develop.



Joint Swelling, Bronchitis, Arthralgia, Gait Disturbance, Joint Stiffness, Urinary Tract Infection, Rheumatoid Arthritis

This Rheumatoid Arthritis side effect was reported by a consumer or non-health professional from COUNTRY NOT SPECIFIED. A 71-year-old female patient (weight:NA) experienced the following symptoms/conditions: NA. The patient was prescribed Methotrexate (dosage: NA), which was started on 201306. Concurrently used drugs:
  • Folic Acid
  • Vitamin D
  • Multivitamin
  • Humira
  • Humira
  • Avapro
  • Norvasc
  • Synthroid
When starting to take Methotrexate the consumer reported the following symptoms:
  • Joint Swelling
  • Bronchitis
  • Arthralgia
  • Gait Disturbance
  • Joint Stiffness
  • Urinary Tract Infection
  • Rheumatoid Arthritis
These side effects may potentially be related to Methotrexate.
Gastrointestinal Disorder, Cholelithiasis, Gastritis, Weight Decreased, Duodenitis, Rheumatoid Arthritis, Iron Deficiency Anaemia, Nausea, Vomiting

This Rheumatoid Arthritis Methotrexate side effect was reported by a physician from RS on Feb 24, 2014. A Female , 63 years of age, was diagnosed with and was treated with Methotrexate. The patient presented the following health conditions:
  • Gastrointestinal Disorder
  • Cholelithiasis
  • Gastritis
  • Weight Decreased
  • Duodenitis
  • Rheumatoid Arthritis
  • Iron Deficiency Anaemia
  • Nausea
  • Vomiting
. Methotrexate dosage: 7.5 Mg, Unk. Additional drugs used at the same time: NA. The patient was hospitalized.
Rheumatoid Arthritis

This is a Methotrexate Sodium side effect report of a 57-year-old female patient (weight:NA) from US, suffering from the following symptoms/conditions: NA, who was treated with Methotrexate Sodium (dosage:Unk, start time: NS), combined with: NA., and developed a serious reaction and a Rheumatoid Arthritis side effect. The patient presented with:
  • Rheumatoid Arthritis
which developed after the beginning of treatment. This side effect report can indicate a possible existence of increased vulnerability to Methotrexate Sodium treatment in female patients suffering from NA, resulting in Rheumatoid Arthritis.

Rheumatoid Arthritis, Stomatitis, Oral Disorder, Oral Mucosal Erythema, Oral Pain, Mastication Disorder, Oropharyngeal Plaque

A 52-year-old patient (weight: NA) from IT with the following symptoms: rheumatoid arthritis started Methotrexate treatment (dosage: 2.5 Mg, Qid Once A Week) on NS. Soon after starting Methotrexate treatment, the consumer experienced several side effects, including:
  • Rheumatoid Arthritis
  • Stomatitis
  • Oral Disorder
  • Oral Mucosal Erythema
  • Oral Pain
  • Mastication Disorder
  • Oropharyngeal Plaque
. Concurrently used drugs:
  • Prednisone (7.5 Mg, Every 15 Days)
  • Calcium
  • Cholecalciferol
  • Folic Acid (15 Mg, Bid Once A Week)
  • Rosuvastatin (10 Mg, Qd)
  • Pantoprazole (20 Mg, Qd)
  • Alendronate (70 Mg, Qw)
The patient was hospitalized. This finding indicates that some patients can be more vulnerable to developing Methotrexate side effects, such as Rheumatoid Arthritis.
Rheumatoid Arthritis, Hepatic Enzyme Increased, Injection Site Bruising, Blood Pressure Increased, Hot Flush, Headache, Arthralgia, Back Pain, Pain In Extremity

A female patient from US was prescribed and started Methotrexate Sodium on Sep 04, 2013. Patient felt the following Methotrexate side effects: rheumatoid arthritis, hepatic enzyme increased, injection site bruising, blood pressure increased, hot flush, headache, arthralgia, back pain, pain in extremity Additional patient health information: Female , 69 years of age, weighting 169.8 lb, The consumer reported the following symptoms: was diagnosed with and. Methotrexate Sodium dosage: 2.5 Mg, 6 Tablets Weekly. Concurrently used drugs:
  • Ibuprofen (Unk)
  • Lipitor (40 Mg, Once Daily)
  • Humira (40 Mg, 1 In 2 Wk)
  • Furosemide (Unk)
  • Prednisone (5 Mg, Unk)
  • Prednisone (2.5 Mg, 1 In 1 D)
  • Folic Acid (1 Mg, 1 In 1 D)
  • Folic Acid
Rheumatoid Arthritis

This report suggests a potential Methotrexate Sodium Rheumatoid Arthritis side effect(s) that can have serious consequences. A 69-year-old female patient from US (weight:NA) was diagnosed with the following health condition(s): rheumatoid arthritis and used Methotrexate Sodium (dosage: Unk) starting NS. Soon after starting Methotrexate Sodium the patient began experiencing various side effects, including:
  • Rheumatoid Arthritis
Drugs used concurrently:NA. Although Methotrexate Sodium demonstrated significant improvements in a number of clinically relevant cases, troublesome symptoms, such as Rheumatoid Arthritis, may still occur.
Joint Swelling, Rheumatoid Arthritis, Erythema, Pain, Pain In Extremity, Gait Disturbance, Contusion, Headache, Sinus Headache

An adverse event was reported by a consumer or non-health professional on Jan 29, 2013 by a Female taking Methotrexate (dosage: NA) was diagnosed with and. Location: COUNTRY NOT SPECIFIED , 46 years of age, patient began experiencing various side effects, including: Directly after treatment started, patient experienced the unwanted or unexpected Methotrexate side effects: joint swelling, rheumatoid arthritis, erythema, pain, pain in extremity, gait disturbance, contusion, headache, sinus headache. Additional medications/treatments:
Associated medications used:
  • Cardizem
  • Cardizem
  • Humira 40 Mg/0.8 Ml Pen
  • Humira 40 Mg/0.8 Ml Pen
Rheumatoid Arthritis

This Rheumatoid Arthritis problem was reported by a consumer or non-health professional from US. A 70-year-old female patient (weight: NA) was diagnosed with the following medical condition(s): rheumatoid arthritis.On 201111 a consumer started treatment with Methotrexate Sodium (dosage: Unk). The following drugs/medications were being taken at the same time:
  • Actemra (Unk)
When commencing Methotrexate Sodium, the patient experienced the following unwanted symptoms /side effects:
  • Rheumatoid Arthritis
Although all drugs are carefully tested before they are licensed for use, they carry potential side effect risks. Some side effects, such as Rheumatoid Arthritis, may become evident only after a product is in use by the general population.
Rheumatoid Arthritis, Eyelid Oedema, Erythema Of Eyelid, Soft Tissue Disorder

This is a Methotrexate Sodium side effect report of a 44-year-old female patient (weight: NA) from US. The patient developed the following symptoms/conditions: rheumatoid arthritis aggravated and was treated with Methotrexate Sodium (dosage: Unk) starting 201209. Concurrently used drugs:
  • Epinephrine (Unk)
  • Lidocaine Hcl (0.3%)
  • Restylane (0.5 Ml Injection To The Tear Troughs On Each Side)
  • Plaquenil (Unk)
  • Prednisone (5 Mg, 1x/day)
  • Ambien (As Needed At Night)
  • Celebrex (Unk)
  • Vitamin D (Unk)
Soon after that, the consumer experienced the following of symptoms:
  • Rheumatoid Arthritis
  • Eyelid Oedema
  • Erythema Of Eyelid
  • Soft Tissue Disorder
This opens a possibility that Methotrexate Sodium could cause Rheumatoid Arthritis and that some female patients may be more susceptible.
Rheumatoid Arthritis, Disease Progression, Injection Site Pain

This Rheumatoid Arthritis side effect was reported by a consumer or non-health professional from US on Sep 19, 2012. A female patient from US , 36 years of age, weighting 106.0 lb, was diagnosed with and was treated with Methotrexate. Directly after treatment started, patient experienced the unwanted or unexpected Methotrexate side effects: rheumatoid arthritis, disease progression, injection site pain. Methotrexate dosage: NA. These side effects may potentially be related to Methotrexate.
Visceral Leishmaniasis, Rheumatoid Arthritis, Pancytopenia, Gingival Bleeding, Vasculitic Rash, Rheumatoid Vasculitis

This Rheumatoid Arthritis side effect was reported by a health professional from GB. A 64-year-old patient (weight:NA) experienced the following symptoms/conditions: rheumatoid arthritis flare up,arthritis aggravated. The patient was prescribed Methotrexate (dosage: NA), which was started on NS. Concurrently used drugs:
  • Corticosteroids
When starting to take Methotrexate the consumer reported the following symptoms:
  • Visceral Leishmaniasis
  • Rheumatoid Arthritis
  • Pancytopenia
  • Gingival Bleeding
  • Vasculitic Rash
  • Rheumatoid Vasculitis
The patient was hospitalized. These side effects may potentially be related to Methotrexate.
Rheumatoid Arthritis, Incorrect Dose Administered, Candidiasis, White Blood Cell Count Decreased

This Rheumatoid Arthritis Methotrexate side effect was reported by a pharmacist from US on Sep 12, 2012. A Female , 68 years of age, weighting 125.0 lb, was diagnosed with and was treated with Methotrexate. The patient presented the following health conditions:
  • Rheumatoid Arthritis
  • Incorrect Dose Administered
  • Candidiasis
  • White Blood Cell Count Decreased
. Methotrexate dosage: 8 Tablets Weekly Po. Additional drugs used at the same time: NA. The patient was hospitalized.
Pneumonia, Renal Failure Chronic, Microcytic Anaemia, Rheumatoid Arthritis

This is a Methotrexate side effect report of a 76-year-old female patient (weight:NA) from UNITED KINGDOM, suffering from the following symptoms/conditions: NA, who was treated with Methotrexate (dosage:NA, start time: Nov 15, 2002), combined with:
  • Remicade
, and developed a serious reaction and a Rheumatoid Arthritis side effect. The patient presented with:
  • Pneumonia
  • Renal Failure Chronic
  • Microcytic Anaemia
  • Rheumatoid Arthritis
which developed after the beginning of treatment. This side effect report can indicate a possible existence of increased vulnerability to Methotrexate treatment in female patients suffering from NA, resulting in Rheumatoid Arthritis.
Rheumatoid Arthritis, Abdominal Abscess, Abscess Rupture, Female Genital Tract Fistula, Injection Site Pain, Diverticulitis

A 70-year-old female patient (weight: NA) from UNITED STATES with the following symptoms: NA started Methotrexate treatment (dosage: Unk Unk, Unk) on Nov 21, 2008. Soon after starting Methotrexate treatment, the consumer experienced several side effects, including:
  • Rheumatoid Arthritis
  • Abdominal Abscess
  • Abscess Rupture
  • Female Genital Tract Fistula
  • Injection Site Pain
  • Diverticulitis
. Concurrently used drugs:
  • Enbrel (50 Mg, Qwk)
The patient was hospitalized. This finding indicates that some patients can be more vulnerable to developing Methotrexate side effects, such as Rheumatoid Arthritis.
Hip Fracture, Infection, Rheumatoid Arthritis, Fall

A female patient from UNITED STATES was prescribed and started Methotrexate on Jun 08, 2012. After Methotrexate was administered, patient encountered several Methotrexate side effects: hip fracture, infection, rheumatoid arthritis, fall Additional patient health information: Female , weighting 121.0 lb, The consumer reported the following symptoms: was diagnosed with and. Methotrexate dosage: NA. Concurrently used drugs:
  • Tylenol W/ Codeine No. 4
  • Folic Acid
  • Celebrex
  • Vitamin D
  • Calcium
  • Plaquenil
  • Atenolol
  • Pantoprazole
The patient was hospitalized.
Lung Neoplasm, Treatment Noncompliance, Rheumatoid Arthritis, Pleural Effusion, Condition Aggravated

This report suggests a potential Methotrexate Rheumatoid Arthritis side effect(s) that can have serious consequences. A patient from JAPAN (weight:NA) was diagnosed with the following health condition(s): rheumatoid arthritis and used Methotrexate (dosage: NA) starting Nov 28, 2011. Soon after starting Methotrexate the patient began experiencing various side effects, including:
  • Lung Neoplasm
  • Treatment Noncompliance
  • Rheumatoid Arthritis
  • Pleural Effusion
  • Condition Aggravated
Drugs used concurrently:
  • Calblock
  • Famotidine
The patient was hospitalized. Although Methotrexate demonstrated significant improvements in a number of clinically relevant cases, troublesome symptoms, such as Rheumatoid Arthritis, may still occur.
Arthralgia, Oedema Peripheral, Tooth Disorder, Rheumatoid Arthritis, Toothache

An adverse event was reported by a consumer or non-health professional on May 29, 2012 by a male taking Methotrexate (dosage: NA) . Location: UNITED STATES , weighting 184.2 lb, patient began experiencing various side effects, including: Patient felt the following Methotrexate side effects: arthralgia, oedema peripheral, tooth disorder, rheumatoid arthritis, toothache. Additional medications/treatments:
Multiple prescriptions taken:
  • D3
Rheumatoid Arthritis, Rash Pruritic, Arthralgia, Fall

This Rheumatoid Arthritis problem was reported by a physician from UNITED STATES. A 65-year-old female patient (weight: NA) was diagnosed with the following medical condition(s): NA.On May 12, 2006 a consumer started treatment with Methotrexate (dosage: 1 Mg, Unk). The following drugs/medications were being taken at the same time:
  • Enbrel (50 Mg, Qwk)
When commencing Methotrexate, the patient experienced the following unwanted symptoms /side effects:
  • Rheumatoid Arthritis
  • Rash Pruritic
  • Arthralgia
  • Fall
Although all drugs are carefully tested before they are licensed for use, they carry potential side effect risks. Some side effects, such as Rheumatoid Arthritis, may become evident only after a product is in use by the general population.
Hypercalcaemia, Vomiting, Rheumatoid Arthritis, Dizziness, Balance Disorder, Renal Mass, Fatigue, Lung Cancer Metastatic

This is a Methotrexate side effect report of a 58-year-old female patient (weight: NA) from CANADA. The patient developed the following symptoms/conditions: NA and was treated with Methotrexate (dosage: NA) starting Jun 21, 2011. Concurrently used drugs:
  • Lyrica
  • Orencia (Last Infus On 05jul11,13mar2012(500mg)q4h;11apr12 Lot:1g64569 Exp:ma14;1l66305,exp:sep14 Inf:12)
  • Plaquenil
  • Pantoprazole Sodium
  • Venlafaxine Hcl
  • Domperidone
  • Calcium + Vitamin D
  • Trazodone Hcl
Soon after that, the consumer experienced the following of symptoms:
  • Hypercalcaemia
  • Vomiting
  • Rheumatoid Arthritis
  • Dizziness
  • Balance Disorder
  • Renal Mass
  • Fatigue
  • Lung Cancer Metastatic
The patient was hospitalized. This opens a possibility that Methotrexate could cause Rheumatoid Arthritis and that some female patients may be more susceptible.
Rheumatoid Arthritis

This Rheumatoid Arthritis side effect was reported by a consumer or non-health professional from ARGENTINA on May 22, 2012. A female patient from ARGENTINA , 68 years of age, was treated with Methotrexate. Patient felt the following Methotrexate side effects: rheumatoid arthritis. Methotrexate dosage: Unk.
Multiple prescriptions taken:
  • Enbrel (50 Mg, Weekly)
These side effects may potentially be related to Methotrexate.
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DISCLAIMER: ALL DATA PROVIDED AS-IS, refer to terms of use for additional information.

Methotrexate Rheumatoid Arthritis Causes and Reviews


Rheumatoid arthritis (RA) is a form of arthritis that causes pain, swelling, stiffness and loss of function in your joints. It can affect any joint but is common in the wrist and fingers.

More women than men get rheumatoid arthritis. It often starts in middle age and is most common in older people. You might have the disease for only a short time, or symptoms might come and go. The severe form can last a lifetime.

Rheumatoid arthritis is different from osteoarthritis, the common arthritis that often comes with older age. RA can affect body parts besides joints, such as your eyes, mouth and lungs. RA is an autoimmune disease, which means the arthritis results from your immune system attacking your body's own tissues.

No one knows what causes rheumatoid arthritis. Genes, environment, and hormones might contribute. Treatments include medicine, lifestyle changes, and surgery. These can slow or stop joint damage and reduce pain and swelling.

NIH: National Institute of Arthritis and Musculoskeletal and Skin Diseases


Methotrexate Rheumatoid Arthritis Reviews

Thu, 27 May 2010
I am 60 Years of age. 8 years ago i was falsely diagnosed with Rheumatoid Arthritis, i was started on Methoblastin 5Mg a week, Was not given Folic Acid and Ranitidine within the 5 months of taking the tablets i developed exposed blood vessels and spots, Stomach pains, reflux, Unable to properly swollow food, confussion, memmory loss, anxiety attacks, nightmares, hard on sleeping, high fevers, diahria, halusanations, itching, dry skin, mouth and eyes, coughin, sore tendons etc.. After i had stoped taking it, specialist said the side effects would go away. The side effects have never gone.. I try to controll it by taking Folic Acid 1mg a day, Glusamine (Joint food). 3 days a week i will take a small amount of Milk Thistle. Too much of Milk thistle would cause Mood swings and Constipation. Doctors are no help.
Sat, 18 Dec 2010
I was diagnosed with Rheumatoid Arthritis about 4 years ago when I was 13 or 14, they looked at me and said I had it, they didn't do any blood tests and when they did, nothing showed. But they started me on about 5 mg of Methotrexate, Prednisone, and Naproxen. I was on Methotrexate for about two years, and by the end of that time they had me on about 10 mg through self injection. Then they said that they had misdiagnosed me and I had "hypermobility syndrome" and said I would "grow out of it in time." My long term side effects are now gastrointestinal problems, malnourishment, weight loss of 20+ pounds, candidiasis (yeast infection in esophagus), and insomnia recently.
DISCLAIMER: ALL DATA PROVIDED AS-IS, refer to terms of use for additional information.

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Nausea (321)
Pneumonia (304)
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Rheumatoid Arthritis (260)
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Renal Failure (118)
Hypertension (115)
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Infection (103)
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Paraesthesia (93)
Septic Shock (91)

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