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Methotrexate Sepsis Side Effects

Methotrexate Sepsis Side Effect Reports


The following Methotrexate Sepsis side effect reports were submitted by healthcare professionals and consumers.

This information will help you understand how side effects, such as Sepsis, can occur, and what you can do about them.

A side effect could appear soon after you start Methotrexate or it might take time to develop.



Dyspnoea, Asthenia, Deep Vein Thrombosis, Retroperitoneal Haemorrhage, Mental Status Changes, Sepsis, Shock Haemorrhagic, Metabolic Acidosis, Multi-organ Failure

This Sepsis side effect was reported by a physician from US. A 60-year-old female patient (weight:NA) experienced the following symptoms/conditions: NA. The patient was prescribed Methotrexate (dosage: NA), which was started on NS. Concurrently used drugs:
  • Procarbazine
  • Rituximab
When starting to take Methotrexate the consumer reported the following symptoms:
  • Dyspnoea
  • Asthenia
  • Deep Vein Thrombosis
  • Retroperitoneal Haemorrhage
  • Mental Status Changes
  • Sepsis
  • Shock Haemorrhagic
  • Metabolic Acidosis
  • Multi-organ Failure
The patient was hospitalized. These side effects may potentially be related to Methotrexate.
Hepatic Failure, Leukopenia, Multi-organ Failure, Sepsis, Thrombocytopenia, Systemic Inflammatory Response Syndrome

This Sepsis Methotrexate side effect was reported by a physician from DE on Jan 03, 2014. A male , 52 years of age, weighting 308.6 lb, was diagnosed with and was treated with Methotrexate. The patient presented the following health conditions:
  • Hepatic Failure
  • Leukopenia
  • Multi-organ Failure
  • Sepsis
  • Thrombocytopenia
  • Systemic Inflammatory Response Syndrome
. Methotrexate dosage: NA. Additional drugs used at the same time:
  • Prednisolon (20)
  • Insulin
  • Folsaeure (Daily Dose: 5 Mg Millgram(s) Every Weeks)
  • Ass (100)
  • Ramipril (2.5)
  • Simvastatin (20)
  • Furosemid (40)
Escherichia Test Positive, Necrotising Fasciitis, Sepsis, Neutrophilia

This is a Methotrexate side effect report of a 45-year-old female patient (weight:NA) from COUNTRY NOT SPECIFIED, suffering from the following symptoms/conditions: NA, who was treated with Methotrexate (dosage:NA, start time: NS), combined with:
  • Prednisolone
, and developed a serious reaction and a Sepsis side effect. The patient presented with:
  • Escherichia Test Positive
  • Necrotising Fasciitis
  • Sepsis
  • Neutrophilia
which developed after the beginning of treatment. This side effect report can indicate a possible existence of increased vulnerability to Methotrexate treatment in female patients suffering from NA, resulting in Sepsis.

Thrombocytopenia, Neutropenia, Mental Status Changes, Confusional State, Sepsis, Acute Respiratory Distress Syndrome, Supraventricular Tachycardia

A 49-year-old patient (weight: NA) from COUNTRY NOT SPECIFIED with the following symptoms: NA started Methotrexate treatment (dosage: NA) on NS. Soon after starting Methotrexate treatment, the consumer experienced several side effects, including:
  • Thrombocytopenia
  • Neutropenia
  • Mental Status Changes
  • Confusional State
  • Sepsis
  • Acute Respiratory Distress Syndrome
  • Supraventricular Tachycardia
. Concurrently used drugs:
  • Rituximab
  • Temzolomide 315 Mg Abbott
The patient was hospitalized. This finding indicates that some patients can be more vulnerable to developing Methotrexate side effects, such as Sepsis.
Necrotising Fasciitis, Escherichia Infection, Sepsis

A female patient from COUNTRY NOT SPECIFIED was prescribed and started Methotrexate on Sep 16, 2013. Patient felt the following Methotrexate side effects: necrotising fasciitis, escherichia infection, sepsis Additional patient health information: Female , 45 years of age, The consumer reported the following symptoms: was diagnosed with and. Methotrexate dosage: NA. Concurrently used drugs:
  • Corticosteroids
Lung Infection, Thrombocytopenia, Neutropenia, Sepsis, Mental Status Changes, Bacterial Infection, Localised Intraabdominal Fluid Collection

This report suggests a potential Methotrexate Sepsis side effect(s) that can have serious consequences. A patient from US (weight:NA) was diagnosed with the following health condition(s): NA and used Methotrexate (dosage: NA) starting NS. Soon after starting Methotrexate the patient began experiencing various side effects, including:
  • Lung Infection
  • Thrombocytopenia
  • Neutropenia
  • Sepsis
  • Mental Status Changes
  • Bacterial Infection
  • Localised Intraabdominal Fluid Collection
Drugs used concurrently:
  • Rituximab (moab C2b8 Anti Cd20, Chimeric)
The patient was hospitalized. Although Methotrexate demonstrated significant improvements in a number of clinically relevant cases, troublesome symptoms, such as Sepsis, may still occur.
Sepsis, Lymphoproliferative Disorder, Pseudomonas Test Positive, Granuloma, Epstein-barr Virus Test Positive

An adverse event was reported by a health professional on Sep 10, 2013 by a Female taking Methotrexate (dosage: NA) was diagnosed with and. Location: COUNTRY NOT SPECIFIED , 64 years of age, patient began experiencing various side effects, including: Directly after treatment started, patient experienced the unwanted or unexpected Methotrexate side effects: sepsis, lymphoproliferative disorder, pseudomonas test positive, granuloma, epstein-barr virus test positive. Additional medications/treatments:
Associated medications used:
  • Prednisolone (3 Mg)
The patient was hospitalized.
Infection, Sepsis, Urinary Tract Infection

This Sepsis problem was reported by a physician from US. A 50-year-old patient (weight: NA) was diagnosed with the following medical condition(s): rheumatoid arthritis.On Oct 14, 2011 a consumer started treatment with Methotrexate (methotrexate) Open Label (dosage: NA). The following drugs/medications were being taken at the same time:
  • Humira (adalimumab) Open Label (Unk (40 Mg, 1 In 2 Wk), Sc)
  • Oxaprozin
  • Panadeine Co (codeine, Phosphate And Paracetamol)
  • Naproxen
  • Tadalafil
  • Folic Acid
  • Cyclobenzaprine (cyclobenzaprine)
When commencing Methotrexate (methotrexate) Open Label, the patient experienced the following unwanted symptoms /side effects:
  • Infection
  • Sepsis
  • Urinary Tract Infection
The patient was hospitalized. Although all drugs are carefully tested before they are licensed for use, they carry potential side effect risks. Some side effects, such as Sepsis, may become evident only after a product is in use by the general population.
Viith Nerve Paralysis, Hemiparesis, Sepsis, Dysarthria

This is a Methotrexate side effect report of a 12-year-old female patient (weight: NA) from CO. The patient developed the following symptoms/conditions: NA and was treated with Methotrexate (dosage: 3 Df, Unk) starting Dec 01, 2010. Concurrently used drugs: NA. Soon after that, the consumer experienced the following of symptoms:
  • Viith Nerve Paralysis
  • Hemiparesis
  • Sepsis
  • Dysarthria
This opens a possibility that Methotrexate could cause Sepsis and that some female patients may be more susceptible.
Sepsis, Lymphoproliferative Disorder, Papule, Scab, Pyrexia, Erythema, Skin Lesion, Pseudomonas Infection, Skin Necrosis

This Sepsis side effect was reported by a health professional from JP on Aug 30, 2013. A female patient from JP , 64 years of age, was diagnosed with and was treated with Methotrexate. Directly after treatment started, patient experienced the unwanted or unexpected Methotrexate side effects: sepsis, lymphoproliferative disorder, papule, scab, pyrexia, erythema, skin lesion, pseudomonas infection, skin necrosis. Methotrexate dosage: 5 Mg, Qw2.
Associated medications used:
  • Piperacillin+tazobactam
  • Sulfadiazine
  • Prednisolone
The patient was hospitalized. These side effects may potentially be related to Methotrexate.
Sepsis, Fungal Infection, Acute Disseminated Encephalomyelitis, Altered State Of Consciousness, Gait Disturbance, Somnolence, Paraplegia, Lymphopenia, Pleocytosis

This Sepsis side effect was reported by a health professional from JP. A 61-year-old female patient (weight:NA) experienced the following symptoms/conditions: rheumatoid arthritis. The patient was prescribed Methotrexate (dosage: NA), which was started on NS. Concurrently used drugs:
  • Prednisolone
  • Tumor Necrosis Factor Alpha (tnf-) Inhibitors
  • Abatacept (500 Mg, Every 30 Days)
When starting to take Methotrexate the consumer reported the following symptoms:
  • Sepsis
  • Fungal Infection
  • Acute Disseminated Encephalomyelitis
  • Altered State Of Consciousness
  • Gait Disturbance
  • Somnolence
  • Paraplegia
  • Lymphopenia
  • Pleocytosis
The patient was hospitalized. These side effects may potentially be related to Methotrexate.
Toxic Epidermal Necrolysis, Bone Marrow Failure, Sepsis, Multi-organ Disorder, Multi-organ Failure

This Sepsis Methotrexate side effect was reported by a health professional from IN on May 22, 2013. A Female , 16 years of age, was diagnosed with and was treated with Methotrexate. The patient presented the following health conditions:
  • Toxic Epidermal Necrolysis
  • Bone Marrow Failure
  • Sepsis
  • Multi-organ Disorder
  • Multi-organ Failure
. Methotrexate dosage: NA. Additional drugs used at the same time:
  • Folinic Acid (folinic Acid)(folinic Acid)
Pulmonary Veno-occlusive Disease, Cytomegalovirus Infection, Mucosal Inflammation, Sepsis, Pulmonary Haemorrhage, Pneumonitis, Pulmonary Hypertension, Respiratory Failure, Idiopathic Pneumonia Syndrome

This is a Methotrexate side effect report of a 8-year-old female patient (weight:NA) from GB, suffering from the following symptoms/conditions: prophylaxis against graft versus host disease, who was treated with Methotrexate (dosage:NA, start time: NS), combined with:
  • Ciclosporin
  • Busulfan (14 Mg/kg, Unk)
  • Cyclophosphamide (200 Mg/kg, Unk)
  • Alemtuzumab (0.3 Mg/kg, Unk)
, and developed a serious reaction and a Sepsis side effect. The patient presented with:
  • Pulmonary Veno-occlusive Disease
  • Cytomegalovirus Infection
  • Mucosal Inflammation
  • Sepsis
  • Pulmonary Haemorrhage
  • Pneumonitis
  • Pulmonary Hypertension
  • Respiratory Failure
  • Idiopathic Pneumonia Syndrome
which developed after the beginning of treatment. This side effect report can indicate a possible existence of increased vulnerability to Methotrexate treatment in female patients suffering from prophylaxis against graft versus host disease, resulting in Sepsis.
Staphylococcal Infection, Abscess, Fall, Vomiting, Sepsis, Shock, Cellulitis

A 69-year-old patient (weight: NA) from US with the following symptoms: NA started Methotrexate (methotrexate) treatment (dosage: (1 In 1 Wk)) on May 24, 2012. Soon after starting Methotrexate (methotrexate) treatment, the consumer experienced several side effects, including:
  • Staphylococcal Infection
  • Abscess
  • Fall
  • Vomiting
  • Sepsis
  • Shock
  • Cellulitis
. Concurrently used drugs:
  • Humira ((1 In 2 Wk))
  • Telmisartan
  • Acetylsalicyilc Acid (acetylsalicylic Acid)
  • Metoprolol Tartrate (metoprolol Tartrate) (tablets) (metoprolol Tartrate)
  • Rosuvastatin Calcium (rosuvastatin Calcium)
  • Clopidogrel Bisulfate (clopidogrel Bisulfate)
  • Paracetamol (paracetamol)
  • Omeprazole Magnesium (omeprazole Magnesium)
The patient was hospitalized. This finding indicates that some patients can be more vulnerable to developing Methotrexate (methotrexate) side effects, such as Sepsis.
Duodenal Ulcer Perforation, Sepsis

A female patient from COUNTRY NOT SPECIFIED was prescribed and started Methotrexate on May 17, 2013. After Methotrexate was administered, patient encountered several Methotrexate side effects: duodenal ulcer perforation, sepsis Additional patient health information: Female , 64 years of age, The consumer reported the following symptoms: was diagnosed with and. Methotrexate dosage: NA. Concurrently used drugs:
  • Etanercept
  • Prednisolone
  • Sulfasalazine
  • Hydroxychloroquine
Sepsis

This report suggests a potential Methotrexate Sodium Sepsis side effect(s) that can have serious consequences. A 15-year-old patient from CN (weight:NA) was diagnosed with the following health condition(s): acute lymphocytic leukaemia and used Methotrexate Sodium (dosage: Unk) starting NS. Soon after starting Methotrexate Sodium the patient began experiencing various side effects, including:
  • Sepsis
Drugs used concurrently:
  • Dexamethasone Sodium Phosphate
  • Cytarabine (Unk)
  • Daunorubicin Hcl (Unk)
  • Mercaptopurine (Unk)
  • Cyclophosphamide (Unk)
  • Vincristine (Unk)
  • Prednisone (Unk)
  • Thioguanine
Although Methotrexate Sodium demonstrated significant improvements in a number of clinically relevant cases, troublesome symptoms, such as Sepsis, may still occur.
Tumour Lysis Syndrome, Sepsis, Renal Failure Acute

An adverse event was reported by a physician on May 16, 2013 by a male taking Methotrexate Sodium (dosage: Unk) was diagnosed with and. Location: CN , child 11 years of age, patient began experiencing various side effects, including: Patient felt the following Methotrexate side effects: tumour lysis syndrome, sepsis, renal failure acute. Additional medications/treatments:
Multiple prescriptions taken:
  • Dexamethasone Sodium Phosphate (Unk)
  • Cytarabine (Unk)
  • Daunorubicin Hcl (Unk)
  • Mercaptopurine (Unk)
  • Cyclophosphamide (Unk)
  • Vincristine (Unk)
  • Prednisone (Unk)
  • Thioguanine
Shock, Tumour Lysis Syndrome, Sepsis, Renal Failure Acute

This Sepsis problem was reported by a physician from CN. A 17-year-old patient (weight: NA) was diagnosed with the following medical condition(s): acute lymphocytic leukaemia.On NS a consumer started treatment with Methotrexate (dosage: Unk). The following drugs/medications were being taken at the same time:
  • Dexamethasone Sodium Phosphate (Unk)
  • Cytarabine (Unk)
  • Daunorubicin Hcl (Unk)
  • Vincristine (Unk)
  • Cyclophosphamide (Unk)
  • Mercaptopurine (Unk)
  • Prednisone (Unk)
  • Thioguanine
When commencing Methotrexate, the patient experienced the following unwanted symptoms /side effects:
  • Shock
  • Tumour Lysis Syndrome
  • Sepsis
  • Renal Failure Acute
Although all drugs are carefully tested before they are licensed for use, they carry potential side effect risks. Some side effects, such as Sepsis, may become evident only after a product is in use by the general population.
Encephalopathy, Ascites, Hepatic Cirrhosis, Non-alcoholic Steatohepatitis, Varices Oesophageal, International Normalised Ratio Increased, Hepatic Failure, Sepsis

This is a Methotrexate side effect report of a 57-year-old female patient (weight: NA) from US. The patient developed the following symptoms/conditions: rheumatoid arthritis and was treated with Methotrexate (dosage: NA) starting 1994. Concurrently used drugs: NA. Soon after that, the consumer experienced the following of symptoms:
  • Encephalopathy
  • Ascites
  • Hepatic Cirrhosis
  • Non-alcoholic Steatohepatitis
  • Varices Oesophageal
  • International Normalised Ratio Increased
  • Hepatic Failure
  • Sepsis
The patient was hospitalized. This opens a possibility that Methotrexate could cause Sepsis and that some female patients may be more susceptible.
Pneumonia, Sepsis, Neutropenia, Acute Respiratory Failure, Lymphopenia

This Sepsis side effect was reported by a physician from ES on Aug 15, 2013. A female patient from ES , 68 years of age, was diagnosed with and was treated with Methotrexate. Patient felt the following Methotrexate side effects: pneumonia, sepsis, neutropenia, acute respiratory failure, lymphopenia. Methotrexate dosage: NA.
Multiple prescriptions taken:
  • Prednisone
  • Prednisone
  • Adiro
  • Adiro
  • Clopidogrel
  • Uniket
  • Natecal D
  • Risedronato Sodico
The patient was hospitalized. These side effects may potentially be related to Methotrexate.
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DISCLAIMER: ALL DATA PROVIDED AS-IS, refer to terms of use for additional information.

Methotrexate Sepsis Causes and Reviews


Sepsis is a serious illness. It happens when your body has an overwhelming immune response to a bacterial infection. The chemicals released into the blood to fight the infection trigger widespread inflammation. This leads to blood clots and leaky blood vessels. They cause poor blood flow, which deprives your body's organs of nutrients and oxygen. In severe cases, one or more organs fail. In the worst cases, blood pressure drops and the heart weakens, leading to septic shock.

Anyone can get Sepsis, but the risk is higher in

  • People with weakened immune systems
  • Infants and children
  • The elderly
  • People with chronic illnesses, such as diabetes, AIDS, cancer, and kidney or liver disease
  • People suffering from a severe burn or physical trauma

Common symptoms of Sepsis are fever, chills, rapid breathing and heart rate, rash, confusion, and disorientation. Doctors diagnose Sepsis using a blood test to see if the number of white blood cells is abnormal. They also do lab tests that check for signs of infection.

People with Sepsis are usually treated in hospital intensive care units. Doctors try to treat the infection, sustain the vital organs, and prevent a drop in blood pressure. Many patients receive oxygen and intravenous (IV) fluids. Other types of treatment, such as respirators or kidney dialysis, may be necessary. Sometimes, surgery is needed to clear up an infection.

NIH: National Institute of General Medical Sciences


Methotrexate Sepsis Reviews

Mon, 21 Feb 2011

My 27 years of MTX therapy have prevented physical deformity but caused me to have damage to my lungs. I am short of breath on any activity. MTX helped the pain somewhat but at the cost of my lungs? I was never told about this possibility nor told it ultimately RA could be fatal. I am only in my 50's not ready to die yet!

Sat, 26 Oct 2013

has anybody had any positive affects from taking " Methoblastin " (Methotrexate) for psoaratic arthritis ? these reviews sound terrible and i have been told to go on it... im a little scared now :(

Sun, 15 May 2011

I have been on Methotrexate for almost months and last two weeks have had severe pains at times lower back , It feel like the kidneys because one side hurts at times and in the mornings it is worse. I am 3 days shy of talking another blood test. Is there anything I can do other than drink a lot of water. Thank you

Sat, 20 Dec 2008
Hi I haven't had any side effects for the past six years of Methotrexate. but recently I am having some stomach discomfort like as soon as i eat something i have the slight discomfort on my abdoman. I take a glass of green leaf juice and i am fine again. I would want to know if I should reduce the dose.
Sun, 24 Jan 2010
I just started Methotrexate, I started itching in the same areas where I had experienced itching with the chicken pox 2 years ago. I am a 51 year old female who contracted chicken pox at 49 years old. This frightens me as I know this can cause disseminated herpes which can be potentially fatal. My Rheum told me to take Benadryl. I believe this is going to be my one and only shot this drug scares the death out of me.
Tue, 27 Apr 2010
painful cough after 2 days of 1st dose lasting-- to date-- 6 days
Thu, 27 May 2010
I am 60 Years of age. 8 years ago i was falsely diagnosed with Rheumatoid Arthritis, i was started on Methoblastin 5Mg a week, Was not given Folic Acid and Ranitidine within the 5 months of taking the tablets i developed exposed blood vessels and spots, Stomach pains, reflux, Unable to properly swollow food, confussion, memmory loss, anxiety attacks, nightmares, hard on sleeping, high fevers, diahria, halusanations, itching, dry skin, mouth and eyes, coughin, sore tendons etc.. After i had stoped taking it, specialist said the side effects would go away. The side effects have never gone.. I try to controll it by taking Folic Acid 1mg a day, Glusamine (Joint food). 3 days a week i will take a small amount of Milk Thistle. Too much of Milk thistle would cause Mood swings and Constipation. Doctors are no help.
Sat, 18 Sep 2010
im a 44yrs old female who took Methotrexate for 2yrs with excellent results and no side effects but had to stop taking it when it started lowering my white cells.
DISCLAIMER: ALL DATA PROVIDED AS-IS, refer to terms of use for additional information.

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Renal Failure (118)
Hypertension (115)
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Infection (103)
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Hypotension (95)
Nasopharyngitis (93)
Paraesthesia (93)
Septic Shock (91)

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