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Methotrexate Septic Shock Side Effects

Methotrexate Septic Shock Side Effect Reports


The following Methotrexate Septic Shock side effect reports were submitted by healthcare professionals and consumers.

This information will help you understand how side effects, such as Septic Shock, can occur, and what you can do about them.

A side effect could appear soon after you start Methotrexate or it might take time to develop.



Multi-organ Failure, Septic Shock, Condition Aggravated, Leukoencephalopathy, Aphasia, Mental Status Changes, Pyrexia, Pancytopenia, Faecal Incontinence

This Septic Shock side effect was reported by a health professional from US. A 16-year-old female patient (weight:NA) experienced the following symptoms/conditions: acute lymphocytic leukaemia. The patient was prescribed Methotrexate (dosage: 3 G/m2), which was started on NS. Concurrently used drugs: NA. When starting to take Methotrexate the consumer reported the following symptoms:
  • Multi-organ Failure
  • Septic Shock
  • Condition Aggravated
  • Leukoencephalopathy
  • Aphasia
  • Mental Status Changes
  • Pyrexia
  • Pancytopenia
  • Faecal Incontinence
These side effects may potentially be related to Methotrexate.
Multi-organ Failure, Prescribed Overdose, Toxicity To Various Agents, Septic Shock

This Septic Shock Methotrexate side effect was reported by a health professional from COUNTRY NOT SPECIFIED on Nov 07, 2013. A Female , 75 years of age, was diagnosed with and was treated with Methotrexate. The patient presented the following health conditions:
  • Multi-organ Failure
  • Prescribed Overdose
  • Toxicity To Various Agents
  • Septic Shock
. Methotrexate dosage: 10 Mg. Additional drugs used at the same time: NA.
Toxicity To Various Agents, Septic Shock, Renal Failure, Hepatocellular Injury

This is a Methotrexate side effect report of a 32-year-old female patient (weight:NA) from COUNTRY NOT SPECIFIED, suffering from the following symptoms/conditions: ectopic pregnancy termination, who was treated with Methotrexate (dosage:75 Mg, start time: NS), combined with: NA., and developed a serious reaction and a Septic Shock side effect. The patient presented with:
  • Toxicity To Various Agents
  • Septic Shock
  • Renal Failure
  • Hepatocellular Injury
which developed after the beginning of treatment. This side effect report can indicate a possible existence of increased vulnerability to Methotrexate treatment in female patients suffering from ectopic pregnancy termination, resulting in Septic Shock.

Renal Failure, Pancytopenia, Hepatocellular Injury, Cholestasis, Bone Marrow Failure, Septic Shock, Toxicity To Various Agents, Diarrhoea Haemorrhagic, Dysphagia

A 32-year-old female patient (weight: NA) from TN with the following symptoms: ectopic pregnancy termination started Methotrexate treatment (dosage: 75 Mg, Unk) on NS. Soon after starting Methotrexate treatment, the consumer experienced several side effects, including:
  • Renal Failure
  • Pancytopenia
  • Hepatocellular Injury
  • Cholestasis
  • Bone Marrow Failure
  • Septic Shock
  • Toxicity To Various Agents
  • Diarrhoea Haemorrhagic
  • Dysphagia
. Concurrently used drugs: NA. This finding indicates that some patients can be more vulnerable to developing Methotrexate side effects, such as Septic Shock.
Septic Shock, Pneumonia Bacterial, Toxicity To Various Agents, Blister, Intertrigo

A female patient from US was prescribed and started Methotrexate Sodium on Nov 06, 2013. Patient felt the following Methotrexate side effects: septic shock, pneumonia bacterial, toxicity to various agents, blister, intertrigo Additional patient health information: Female , 66 years of age, The consumer reported the following symptoms: . Methotrexate Sodium dosage: Unk. Concurrently used drugs: NA.
Septic Shock, Toxicity To Various Agents, Multi-organ Failure, Exposure During Pregnancy

This report suggests a potential Methotrexate Septic Shock side effect(s) that can have serious consequences. A 32-year-old female patient from TN (weight:NA) was diagnosed with the following health condition(s): ectopic pregnancy termination and used Methotrexate (dosage: 75mg) starting NS. Soon after starting Methotrexate the patient began experiencing various side effects, including:
  • Septic Shock
  • Toxicity To Various Agents
  • Multi-organ Failure
  • Exposure During Pregnancy
Drugs used concurrently:NA. Although Methotrexate demonstrated significant improvements in a number of clinically relevant cases, troublesome symptoms, such as Septic Shock, may still occur.
Multi-organ Failure, Toxicity To Various Agents, Respiratory Failure, Renal Failure Acute, Septic Shock, Mucosal Inflammation, Pruritus, Abdominal Pain

An adverse event was reported by a health professional on Oct 28, 2013 by a Female taking Methotrexate (dosage: NA) was diagnosed with and. Location: IL , 75 years of age, patient began experiencing various side effects, including: Directly after treatment started, patient experienced the unwanted or unexpected Methotrexate side effects: multi-organ failure, toxicity to various agents, respiratory failure, renal failure acute, septic shock, mucosal inflammation, pruritus, abdominal pain. Additional medications/treatments:
Multi-organ Failure, Terminal State, Septic Shock, Respiratory Failure, Renal Failure Acute, Mucosal Inflammation, Abdominal Pain, Platelet Count Decreased, White Blood Cell Count Decreased

This Septic Shock problem was reported by a health professional from IL. A 75-year-old female patient (weight: NA) was diagnosed with the following medical condition(s): rheumatoid arthritis.On NS a consumer started treatment with Methotrexate (dosage: 10 Mg, Qd Instead Of A Weekly Dose). The following drugs/medications were being taken at the same time: NA. When commencing Methotrexate, the patient experienced the following unwanted symptoms /side effects:
  • Multi-organ Failure
  • Terminal State
  • Septic Shock
  • Respiratory Failure
  • Renal Failure Acute
  • Mucosal Inflammation
  • Abdominal Pain
  • Platelet Count Decreased
  • White Blood Cell Count Decreased
Although all drugs are carefully tested before they are licensed for use, they carry potential side effect risks. Some side effects, such as Septic Shock, may become evident only after a product is in use by the general population.
Toxicity To Various Agents, Respiratory Failure, Renal Failure Acute, Septic Shock, Multi-organ Failure, Pruritus, Mucosal Inflammation, Abdominal Pain

This is a Methotrexate side effect report of a 75-year-old female patient (weight: NA) from IL. The patient developed the following symptoms/conditions: rheumatoid arthritis and was treated with Methotrexate (dosage: NA) starting NS. Concurrently used drugs: NA. Soon after that, the consumer experienced the following of symptoms:
  • Toxicity To Various Agents
  • Respiratory Failure
  • Renal Failure Acute
  • Septic Shock
  • Multi-organ Failure
  • Pruritus
  • Mucosal Inflammation
  • Abdominal Pain
This opens a possibility that Methotrexate could cause Septic Shock and that some female patients may be more susceptible.
Septic Shock, Colitis, Hypotension, Mental Status Changes, Nuclear Magnetic Resonance Imaging Brain Abnormal, Asthenia, Progressive Multifocal Leukoencephalopathy

This Septic Shock side effect was reported by a pharmacist from US on Sep 19, 2013. A female patient from US , child 12 years of age, weighting 78.04 lb, was diagnosed with and was treated with Methotrexate. Directly after treatment started, patient experienced the unwanted or unexpected Methotrexate side effects: septic shock, colitis, hypotension, mental status changes, nuclear magnetic resonance imaging brain abnormal, asthenia, progressive multifocal leukoencephalopathy. Methotrexate dosage: 15 Mg.
Associated medications used:
  • Epinephrine,
  • Norepinephrine,
  • Dobutamine,
  • Milrinone,
  • Vasopressin Infusions Vecuronium (changed To Cisatracurium),
  • Dexmedetomidine,
  • Midazolam Infusions
  • Hydrocortisone Ivp
The patient was hospitalized and became disabled. These side effects may potentially be related to Methotrexate.
Septic Shock, Intraspinal Abscess

This Septic Shock side effect was reported by a physician from DE. A 56-year-old female patient (weight:NA) experienced the following symptoms/conditions: rheumatoid arthritis. The patient was prescribed Methotrexate (dosage: NA), which was started on NS. Concurrently used drugs:
  • Enbrel (50 Mg 1/woche)
When starting to take Methotrexate the consumer reported the following symptoms:
  • Septic Shock
  • Intraspinal Abscess
The patient was hospitalized. These side effects may potentially be related to Methotrexate.
Septic Shock, Coma, Pancytopenia, Multi-organ Failure, Cognitive Disorder, Hepatic Function Abnormal

This Septic Shock Methotrexate side effect was reported by a physician from DE on Aug 30, 2013. A Female , 56 years of age, weighting 189.6 lb, was diagnosed with and was treated with Methotrexate. The patient presented the following health conditions:
  • Septic Shock
  • Coma
  • Pancytopenia
  • Multi-organ Failure
  • Cognitive Disorder
  • Hepatic Function Abnormal
. Methotrexate dosage: NA. Additional drugs used at the same time:
  • Enbrel
The patient was hospitalized.
Cardiac Arrest, Septic Shock, Superinfection, Pneumothorax, Interstitial Lung Disease, Dyspnoea Exertional, Pneumonia

This is a Methotrexate Sandoz side effect report of a 15-year-old female patient (weight:NA) from DK, suffering from the following symptoms/conditions: juvenile idiopathic arthritis, who was treated with Methotrexate Sandoz (dosage:10-15 Mg / Square Meter Weekly Dose, start time: Oct 20, 2010), combined with:
  • Enbrel (50 Mg, Qw)
  • Cyclophosphamide
  • Prednisolon
, and developed a serious reaction and a Septic Shock side effect. The patient presented with:
  • Cardiac Arrest
  • Septic Shock
  • Superinfection
  • Pneumothorax
  • Interstitial Lung Disease
  • Dyspnoea Exertional
  • Pneumonia
which developed after the beginning of treatment. This side effect report can indicate a possible existence of increased vulnerability to Methotrexate Sandoz treatment in female patients suffering from juvenile idiopathic arthritis, resulting in Septic Shock.
Febrile Neutropenia, Septic Shock, Renal Failure Acute, Pancytopenia, Stomatitis, Mouth Ulceration

A 25-year-old female patient (weight: NA) from TN with the following symptoms: psoriasis started Methotrexate treatment (dosage: NA) on NS. Soon after starting Methotrexate treatment, the consumer experienced several side effects, including:
  • Febrile Neutropenia
  • Septic Shock
  • Renal Failure Acute
  • Pancytopenia
  • Stomatitis
  • Mouth Ulceration
. Concurrently used drugs: NA.The patient was hospitalized. This finding indicates that some patients can be more vulnerable to developing Methotrexate side effects, such as Septic Shock.
Febrile Neutropenia, Septic Shock, Pyrexia, Dehydration, Mouth Ulceration, Dysphagia, Salivary Hypersecretion, Tachycardia

A female patient from TN was prescribed and started Methotrexate on Jun 11, 2013. After Methotrexate was administered, patient encountered several Methotrexate side effects: febrile neutropenia, septic shock, pyrexia, dehydration, mouth ulceration, dysphagia, salivary hypersecretion, tachycardia Additional patient health information: Female , 25 years of age, The consumer reported the following symptoms: was diagnosed with and. Methotrexate dosage: 25 Mg, Qw3. Concurrently used drugs: NA. The patient was hospitalized.
Mucosal Inflammation, Pancytopenia, Septic Shock

This report suggests a potential Methotrexate Septic Shock side effect(s) that can have serious consequences. A 81-year-old female patient from DE (weight:NA) was diagnosed with the following health condition(s): rheumatoid arthritis and used Methotrexate (dosage: Unk) starting Jan 16, 2013. Soon after starting Methotrexate the patient began experiencing various side effects, including:
  • Mucosal Inflammation
  • Pancytopenia
  • Septic Shock
Drugs used concurrently:NA. Although Methotrexate demonstrated significant improvements in a number of clinically relevant cases, troublesome symptoms, such as Septic Shock, may still occur.
Septic Shock, Escherichia Sepsis, Oral Herpes, Herpes Ophthalmic, Aplasia, Graft Complication

An adverse event was reported by a physician on Apr 03, 2013 by a male taking Methotrexate (dosage: Unk) was diagnosed with and. Location: HU , child 11 years of age, patient began experiencing various side effects, including: Patient felt the following Methotrexate side effects: septic shock, escherichia sepsis, oral herpes, herpes ophthalmic, aplasia, graft complication. Additional medications/treatments:
Multiple prescriptions taken:
  • Cyclosporine (Unk)
  • Fludarabine
  • Cyclophosphamide (60 Mg/kg, Daily)
  • Busulfan (0.8 Mg/kg, Daily)
  • Antithymocyte Immunoglobulin (2.5 Mg/kg, Unk)
  • Antithymocyte Immunoglobulin (2.5 Mg/kg, Unk)
  • Melphalan (140 Mg/m2, Single)
Septic Shock, Escherichia Sepsis, Oral Herpes, Stomatitis, Herpes Ophthalmic

This Septic Shock problem was reported by a physician from HU. A 11-year-old patient (weight: NA) was diagnosed with the following medical condition(s): prophylaxis against graft versus host disease.On NS a consumer started treatment with Methotrexate (dosage: NA). The following drugs/medications were being taken at the same time:
  • Cyclosporine
  • Fludarabine
  • Cyclophosphamide
  • Busulfan
  • Antithymocyte Immunoglobulin
  • Antithymocyte Immunoglobulin
  • Melphalan (140 Mg/m2, Single)
When commencing Methotrexate, the patient experienced the following unwanted symptoms /side effects:
  • Septic Shock
  • Escherichia Sepsis
  • Oral Herpes
  • Stomatitis
  • Herpes Ophthalmic
Although all drugs are carefully tested before they are licensed for use, they carry potential side effect risks. Some side effects, such as Septic Shock, may become evident only after a product is in use by the general population.
Pneumonia, Septic Shock, Fatigue, Dyspnoea, Pyrexia, Respiratory Failure

This is a Methotrexate side effect report of a 68-year-old female patient (weight: NA) from TH. The patient developed the following symptoms/conditions: rheumatoid arthritis and was treated with Methotrexate (dosage: 1.0714 Milligram Daily;) starting Mar 21, 2008. Concurrently used drugs: NA. Soon after that, the consumer experienced the following of symptoms:
  • Pneumonia
  • Septic Shock
  • Fatigue
  • Dyspnoea
  • Pyrexia
  • Respiratory Failure
The patient was hospitalized. This opens a possibility that Methotrexate could cause Septic Shock and that some female patients may be more susceptible.
Pneumonia, Multi-organ Failure, Septic Shock, Acute Respiratory Distress Syndrome, Pancytopenia, Immunodeficiency

This Septic Shock side effect was reported by a health professional from ES on Nov 07, 2012. A female patient from ES , 78 years of age, was diagnosed with and was treated with Methotrexate. Patient felt the following Methotrexate side effects: pneumonia, multi-organ failure, septic shock, acute respiratory distress syndrome, pancytopenia, immunodeficiency. Methotrexate dosage: NA.
Multiple prescriptions taken:
  • Etanercept
  • Prednisone (Daily Prednisone)
The patient was hospitalized. These side effects may potentially be related to Methotrexate.
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DISCLAIMER: ALL DATA PROVIDED AS-IS, refer to terms of use for additional information.

Methotrexate Septic Shock Causes and Reviews


Sepsis is a serious illness. It happens when your body has an overwhelming immune response to a bacterial infection. The chemicals released into the blood to fight the infection trigger widespread inflammation. This leads to blood clots and leaky blood vessels. They cause poor blood flow, which deprives your body's organs of nutrients and oxygen. In severe cases, one or more organs fail. In the worst cases, blood pressure drops and the heart weakens, leading to septic shock.

Anyone can get sepsis, but the risk is higher in

  • People with weakened immune systems
  • Infants and children
  • The elderly
  • People with chronic illnesses, such as diabetes, AIDS, cancer, and kidney or liver disease
  • People suffering from a severe burn or physical trauma

Common symptoms of sepsis are fever, chills, rapid breathing and heart rate, rash, confusion, and disorientation. Doctors diagnose sepsis using a blood test to see if the number of white blood cells is abnormal. They also do lab tests that check for signs of infection.

People with sepsis are usually treated in hospital intensive care units. Doctors try to treat the infection, sustain the vital organs, and prevent a drop in blood pressure. Many patients receive oxygen and intravenous (IV) fluids. Other types of treatment, such as respirators or kidney dialysis, may be necessary. Sometimes, surgery is needed to clear up an infection.

NIH: National Institute of General Medical Sciences


Methotrexate Septic Shock Reviews

Mon, 21 Feb 2011

My 27 years of MTX therapy have prevented physical deformity but caused me to have damage to my lungs. I am short of breath on any activity. MTX helped the pain somewhat but at the cost of my lungs? I was never told about this possibility nor told it ultimately RA could be fatal. I am only in my 50's not ready to die yet!

Sat, 26 Oct 2013

has anybody had any positive affects from taking " Methoblastin " (Methotrexate) for psoaratic arthritis ? these reviews sound terrible and i have been told to go on it... im a little scared now :(

Sun, 15 May 2011

I have been on Methotrexate for almost months and last two weeks have had severe pains at times lower back , It feel like the kidneys because one side hurts at times and in the mornings it is worse. I am 3 days shy of talking another blood test. Is there anything I can do other than drink a lot of water. Thank you

Sat, 20 Dec 2008
Hi I haven't had any side effects for the past six years of Methotrexate. but recently I am having some stomach discomfort like as soon as i eat something i have the slight discomfort on my abdoman. I take a glass of green leaf juice and i am fine again. I would want to know if I should reduce the dose.
Sun, 24 Jan 2010
I just started Methotrexate, I started itching in the same areas where I had experienced itching with the chicken pox 2 years ago. I am a 51 year old female who contracted chicken pox at 49 years old. This frightens me as I know this can cause disseminated herpes which can be potentially fatal. My Rheum told me to take Benadryl. I believe this is going to be my one and only shot this drug scares the death out of me.
Tue, 27 Apr 2010
painful cough after 2 days of 1st dose lasting-- to date-- 6 days
Thu, 27 May 2010
I am 60 Years of age. 8 years ago i was falsely diagnosed with Rheumatoid Arthritis, i was started on Methoblastin 5Mg a week, Was not given Folic Acid and Ranitidine within the 5 months of taking the tablets i developed exposed blood vessels and spots, Stomach pains, reflux, Unable to properly swollow food, confussion, memmory loss, anxiety attacks, nightmares, hard on sleeping, high fevers, diahria, halusanations, itching, dry skin, mouth and eyes, coughin, sore tendons etc.. After i had stoped taking it, specialist said the side effects would go away. The side effects have never gone.. I try to controll it by taking Folic Acid 1mg a day, Glusamine (Joint food). 3 days a week i will take a small amount of Milk Thistle. Too much of Milk thistle would cause Mood swings and Constipation. Doctors are no help.
Sat, 18 Sep 2010
im a 44yrs old female who took Methotrexate for 2yrs with excellent results and no side effects but had to stop taking it when it started lowering my white cells.
DISCLAIMER: ALL DATA PROVIDED AS-IS, refer to terms of use for additional information.

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Paraesthesia (93)
Septic Shock (91)

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