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Methotrexate Thrombocytopenia Side Effects

Methotrexate Thrombocytopenia Side Effect Reports


The following Methotrexate Thrombocytopenia side effect reports were submitted by healthcare professionals and consumers.

This information will help you understand how side effects, such as Thrombocytopenia, can occur, and what you can do about them.

A side effect could appear soon after you start Methotrexate or it might take time to develop.



Radiation Pneumonitis, Pulmonary Toxicity, Rash, Febrile Neutropenia, Thrombocytopenia

This Thrombocytopenia side effect was reported by a health professional from COUNTRY NOT SPECIFIED. A 17-year-old female patient (weight:NA) experienced the following symptoms/conditions: osteosarcoma metastatic. The patient was prescribed Methotrexate (dosage: NA), which was started on NS. Concurrently used drugs:
  • Doxorubicin
  • Cisplatin
  • Etoposide
  • Ifosfamide
When starting to take Methotrexate the consumer reported the following symptoms:
  • Radiation Pneumonitis
  • Pulmonary Toxicity
  • Rash
  • Febrile Neutropenia
  • Thrombocytopenia
These side effects may potentially be related to Methotrexate.
Acute Myeloid Leukaemia, Thrombocytopenia, Neutropenia, Hypochromic Anaemia, Bone Marrow Failure, Spur Cell Anaemia, Dyspnoea

This Thrombocytopenia Methotrexate side effect was reported by a health professional from US on Feb 17, 2014. A Female , 65 years of age, was diagnosed with and was treated with Methotrexate. The patient presented the following health conditions:
  • Acute Myeloid Leukaemia
  • Thrombocytopenia
  • Neutropenia
  • Hypochromic Anaemia
  • Bone Marrow Failure
  • Spur Cell Anaemia
  • Dyspnoea
. Methotrexate dosage: 40 Mg/m2, Days 1 And 8. Additional drugs used at the same time:
  • 5-fluorouracil (600 Mg/m2, Days 1 And 8)
  • Cyclophosphamide (100 Mg/m2, Unk)
Cardiovascular Insufficiency, Cardiac Arrest, Respiratory Failure, Dyspnoea, Face Oedema, C-reactive Protein Increased, Leukopenia, Thrombocytopenia

This is a Methotrexate side effect report of a 49-year-old patient (weight:NA) from PL, suffering from the following symptoms/conditions: NA, who was treated with Methotrexate (dosage:1 Df, Qd, start time: Jun 30, 2009), combined with: NA., and developed a serious reaction and a Thrombocytopenia side effect. The patient presented with:
  • Cardiovascular Insufficiency
  • Cardiac Arrest
  • Respiratory Failure
  • Dyspnoea
  • Face Oedema
  • C-reactive Protein Increased
  • Leukopenia
  • Thrombocytopenia
which developed after the beginning of treatment. The patient was hospitalized. This side effect report can indicate a possible existence of increased vulnerability to Methotrexate treatment in patients suffering from NA, resulting in Thrombocytopenia.

Febrile Neutropenia, Dermatitis, Thrombocytopenia, Stomatitis, Alopecia, Diarrhoea, Maternal Exposure During Pregnancy, Mouth Ulceration, Haematocrit Decreased

A 33-year-old female patient (weight: NA) from TR with the following symptoms: ectopic pregnancy started Methotrexate treatment (dosage: NA) on NS. Soon after starting Methotrexate treatment, the consumer experienced several side effects, including:
  • Febrile Neutropenia
  • Dermatitis
  • Thrombocytopenia
  • Stomatitis
  • Alopecia
  • Diarrhoea
  • Maternal Exposure During Pregnancy
  • Mouth Ulceration
  • Haematocrit Decreased
. Concurrently used drugs: NA. This finding indicates that some patients can be more vulnerable to developing Methotrexate side effects, such as Thrombocytopenia.
Thrombocytopenia, Pancytopenia

A female patient from COUNTRY NOT SPECIFIED was prescribed and started Methotrexate on Jan 17, 2014. Patient felt the following Methotrexate side effects: thrombocytopenia, pancytopenia Additional patient health information: Female , 86 years of age, The consumer reported the following symptoms: was diagnosed with and. Methotrexate dosage: NA. Concurrently used drugs:
  • Ciprofloxacin (1000 Mg)
  • Allopurinol
  • Alendronic Acid
  • Venlafaxine
Bone Marrow Failure, Agranulocytosis, Febrile Neutropenia, Folate Deficiency, Thrombocytopenia, Pyrexia, Alopecia, Dermatitis, Diarrhoea

This report suggests a potential Methotrexate Thrombocytopenia side effect(s) that can have serious consequences. A 33-year-old female patient from TR (weight:NA) was diagnosed with the following health condition(s): NA and used Methotrexate (dosage: 75 Mg According To 50 Mg/m2 Regimen) starting NS. Soon after starting Methotrexate the patient began experiencing various side effects, including:
  • Bone Marrow Failure
  • Agranulocytosis
  • Febrile Neutropenia
  • Folate Deficiency
  • Thrombocytopenia
  • Pyrexia
  • Alopecia
  • Dermatitis
  • Diarrhoea
Drugs used concurrently:
  • Methylprednisolone (40 Mg, Unk)
  • Folinic Acid (7.5 Mg, Unk)
  • Filgrastim (30 Ml, Bid)
  • Diphenoxylate Hydrochloride
  • Calcium Folinate (15 Mg, Qid)
  • Meropenem (500 Mg, Tid)
  • Teicoplanin (400 Mg, Once/single)
  • Nystatin (1 Df, Qid)
Although Methotrexate demonstrated significant improvements in a number of clinically relevant cases, troublesome symptoms, such as Thrombocytopenia, may still occur.
Hepatic Failure, Leukopenia, Multi-organ Failure, Sepsis, Thrombocytopenia, Systemic Inflammatory Response Syndrome

An adverse event was reported by a physician on Jan 03, 2014 by a male taking Methotrexate (dosage: NA) was diagnosed with and. Location: DE , 52 years of age, weighting 308.6 lb, patient began experiencing various side effects, including: Directly after treatment started, patient experienced the unwanted or unexpected Methotrexate side effects: hepatic failure, leukopenia, multi-organ failure, sepsis, thrombocytopenia, systemic inflammatory response syndrome. Additional medications/treatments:
Associated medications used:
  • Prednisolon (20)
  • Insulin
  • Folsaeure (Daily Dose: 5 Mg Millgram(s) Every Weeks)
  • Ass (100)
  • Ramipril (2.5)
  • Simvastatin (20)
  • Furosemid (40)
Pulmonary Toxicity, Pneumonitis, Radiation Pneumonitis, Rash, Febrile Neutropenia, Thrombocytopenia

This Thrombocytopenia problem was reported by a health professional from NO. A 17-year-old female patient (weight: NA) was diagnosed with the following medical condition(s): metastases to lung,bone sarcoma,osteosarcoma metastatic.On NS a consumer started treatment with Methotrexate Sodium (dosage: Daily Dose: 12g/m 3 Per Administration At Weeks 4 And 5). The following drugs/medications were being taken at the same time: NA. When commencing Methotrexate Sodium, the patient experienced the following unwanted symptoms /side effects:
  • Pulmonary Toxicity
  • Pneumonitis
  • Radiation Pneumonitis
  • Rash
  • Febrile Neutropenia
  • Thrombocytopenia
The patient was hospitalized. Although all drugs are carefully tested before they are licensed for use, they carry potential side effect risks. Some side effects, such as Thrombocytopenia, may become evident only after a product is in use by the general population.
Pulmonary Toxicity, Radiation Pneumonitis, Dyspnoea, Lung Disorder, Chest Pain, Rash, Febrile Neutropenia, Thrombocytopenia, Osteosarcoma Metastatic

This is a Methotrexate side effect report of a 17-year-old female patient (weight: NA) from NO. The patient developed the following symptoms/conditions: osteosarcoma,metastases to lung,bone cancer metastatic,off label use and was treated with Methotrexate (dosage: 24000 Mg/m2, Unk) starting NS. Concurrently used drugs: NA. Soon after that, the consumer experienced the following of symptoms:
  • Pulmonary Toxicity
  • Radiation Pneumonitis
  • Dyspnoea
  • Lung Disorder
  • Chest Pain
  • Rash
  • Febrile Neutropenia
  • Thrombocytopenia
  • Osteosarcoma Metastatic
This opens a possibility that Methotrexate could cause Thrombocytopenia and that some female patients may be more susceptible.
Anaemia, Thrombocytopenia, Leukopenia

This Thrombocytopenia side effect was reported by a health professional from FR on Dec 16, 2013. A patient from FR , 33 years of age, weighting 372.6 lb, was diagnosed with and was treated with Methotrexate. Directly after treatment started, patient experienced the unwanted or unexpected Methotrexate side effects: anaemia, thrombocytopenia, leukopenia. Methotrexate dosage: NA.
Associated medications used:
  • Lovenox
  • Viramune
  • Keppra
  • Wellvone
  • Ziagen
  • Calcium Folinate
  • Epivir
  • Multivitamins
The patient was hospitalized. These side effects may potentially be related to Methotrexate.
Thrombocytopenia, Neutropenia, Mental Status Changes, Confusional State, Sepsis, Acute Respiratory Distress Syndrome, Supraventricular Tachycardia

This Thrombocytopenia side effect was reported by a consumer or non-health professional from COUNTRY NOT SPECIFIED. A 49-year-old patient (weight:NA) experienced the following symptoms/conditions: NA. The patient was prescribed Methotrexate (dosage: NA), which was started on NS. Concurrently used drugs:
  • Rituximab
  • Temzolomide 315 Mg Abbott
When starting to take Methotrexate the consumer reported the following symptoms:
  • Thrombocytopenia
  • Neutropenia
  • Mental Status Changes
  • Confusional State
  • Sepsis
  • Acute Respiratory Distress Syndrome
  • Supraventricular Tachycardia
The patient was hospitalized. These side effects may potentially be related to Methotrexate.
Lung Infection, Thrombocytopenia, Neutropenia, Sepsis, Mental Status Changes, Bacterial Infection, Localised Intraabdominal Fluid Collection

This Thrombocytopenia Methotrexate side effect was reported by a health professional from US on Sep 13, 2013. A male , weighting 249.1 lb, was treated with Methotrexate. The patient presented the following health conditions:
  • Lung Infection
  • Thrombocytopenia
  • Neutropenia
  • Sepsis
  • Mental Status Changes
  • Bacterial Infection
  • Localised Intraabdominal Fluid Collection
. Methotrexate dosage: NA. Additional drugs used at the same time:
  • Rituximab (moab C2b8 Anti Cd20, Chimeric)
The patient was hospitalized.
Agranulocytosis, Mucosal Inflammation, Thrombocytopenia

This is a Methotrexate side effect report of a 11-year-old female patient (weight:NA) from FR, suffering from the following symptoms/conditions: acute lymphocytic leukaemia, who was treated with Methotrexate (dosage:NA, start time: Jul 01, 2013), combined with: NA., and developed a serious reaction and a Thrombocytopenia side effect. The patient presented with:
  • Agranulocytosis
  • Mucosal Inflammation
  • Thrombocytopenia
which developed after the beginning of treatment. The patient was hospitalized. This side effect report can indicate a possible existence of increased vulnerability to Methotrexate treatment in female patients suffering from acute lymphocytic leukaemia, resulting in Thrombocytopenia.
Agranulocytosis, Mucosal Inflammation, Thrombocytopenia

A 11-year-old female patient (weight: NA) from FR with the following symptoms: acute lymphocytic leukaemia started Methotrexate treatment (dosage: NA) on Jul 01, 2013. Soon after starting Methotrexate treatment, the consumer experienced several side effects, including:
  • Agranulocytosis
  • Mucosal Inflammation
  • Thrombocytopenia
. Concurrently used drugs: NA.The patient was hospitalized. This finding indicates that some patients can be more vulnerable to developing Methotrexate side effects, such as Thrombocytopenia.
Dermatitis, Parakeratosis, Skin Erosion, Pain, Blister, Thrombocytopenia, Pancytopenia, Eosinophil Count Increased, Toxicity To Various Agents

A patient from US was prescribed and started Methotrexate on Jul 01, 2013. After Methotrexate was administered, patient encountered several Methotrexate side effects: dermatitis, parakeratosis, skin erosion, pain, blister, thrombocytopenia, pancytopenia, eosinophil count increased, toxicity to various agents Additional patient health information: male , 79 years of age, The consumer reported the following symptoms: was diagnosed with and. Methotrexate dosage: 12.5 Mg, Qw. Concurrently used drugs: NA.
Immunosuppression, Anaemia, Neutropenia, Thrombocytopenia, Diarrhoea, Urinary Tract Infection, Arteriovenous Fistula Site Infection, Enterococcal Infection, Endocarditis

This report suggests a potential Methotrexate Sodium Thrombocytopenia side effect(s) that can have serious consequences. A 52-year-old female patient from AU (weight:NA) was diagnosed with the following health condition(s): central nervous system lymphoma and used Methotrexate Sodium (dosage: 1g/m2; Total Dose 1600mg Over 2 Hours Every 2 Weeks) starting NS. Soon after starting Methotrexate Sodium the patient began experiencing various side effects, including:
  • Immunosuppression
  • Anaemia
  • Neutropenia
  • Thrombocytopenia
  • Diarrhoea
  • Urinary Tract Infection
  • Arteriovenous Fistula Site Infection
  • Enterococcal Infection
  • Endocarditis
Drugs used concurrently:
  • Dexamethasone Sodium Phosphate
  • Cytarabine (100mg)
  • Rituximab (375 Mg/m2, Weekly X 8)
  • Leucovorin (60mg Iv 12 Hours After Mtx Infusion)
  • Leucovorin (50mg Iv Q6h X 2)
  • Leucovorin (200mg Iv Q4h X 12 Doses)
  • Leucovorin (50mg Iv Q6h X 15)
  • Leucovorin (200mg Iv Q6h X 10 Doses)
Although Methotrexate Sodium demonstrated significant improvements in a number of clinically relevant cases, troublesome symptoms, such as Thrombocytopenia, may still occur.
Subarachnoid Haemorrhage, Subdural Haematoma, Intracranial Aneurysm, Thrombocytopenia, Bone Marrow Failure

An adverse event was reported by a health professional on May 18, 2013 by a Female taking Methotrexate (dosage: NA) was diagnosed with and. Location: COUNTRY NOT SPECIFIED , 70 years of age, weighting 121.3 lb, patient began experiencing various side effects, including: Patient felt the following Methotrexate side effects: subarachnoid haemorrhage, subdural haematoma, intracranial aneurysm, thrombocytopenia, bone marrow failure. Additional medications/treatments:
Multiple prescriptions taken:
  • Prednisolone (3 Mg)
Thrombocytopenia, Anaemia, Leukopenia, Neutropenia, Hypokalaemia, Febrile Neutropenia

This Thrombocytopenia problem was reported by a physician from US. A 9.-year-old patient (weight: NA) was diagnosed with the following medical condition(s): acute lymphocytic leukaemia.On Jan 28, 2013 a consumer started treatment with Methotrexate (dosage: NA). The following drugs/medications were being taken at the same time:
  • Vincristine
  • Dasatinib (65 Milligram Daily;)
  • Hydrocortisone
  • Dexamethasone
  • Cytarabine
  • Cyclophosphamide
  • Methylprednisolone
  • Leucovorin (6 Hours)
When commencing Methotrexate, the patient experienced the following unwanted symptoms /side effects:
  • Thrombocytopenia
  • Anaemia
  • Leukopenia
  • Neutropenia
  • Hypokalaemia
  • Febrile Neutropenia
The patient was hospitalized. Although all drugs are carefully tested before they are licensed for use, they carry potential side effect risks. Some side effects, such as Thrombocytopenia, may become evident only after a product is in use by the general population.
Colonic Pseudo-obstruction, Neutropenia, Anaemia, Thrombocytopenia, Hypokalaemia, Proctocolitis, Ileus, Blood Culture Positive, Yersinia Test Positive

This is a Methotrexate side effect report of a 70-year-old female patient (weight: NA) from US. The patient developed the following symptoms/conditions: central nervous system lymphoma and was treated with Methotrexate (dosage: NA) starting NS. Concurrently used drugs:
  • Omeprazole
  • Metoprol
Soon after that, the consumer experienced the following of symptoms:
  • Colonic Pseudo-obstruction
  • Neutropenia
  • Anaemia
  • Thrombocytopenia
  • Hypokalaemia
  • Proctocolitis
  • Ileus
  • Blood Culture Positive
  • Yersinia Test Positive
The patient was hospitalized. This opens a possibility that Methotrexate could cause Thrombocytopenia and that some female patients may be more susceptible.
Grand Mal Convulsion, Renal Failure Acute, Mucosal Inflammation, Thrombocytopenia, Haemodialysis, Toxicity To Various Agents

This Thrombocytopenia side effect was reported by a pharmacist from US on Jan 22, 2013. A patient from US , 25 years of age, was diagnosed with and was treated with Methotrexate. Patient felt the following Methotrexate side effects: grand mal convulsion, renal failure acute, mucosal inflammation, thrombocytopenia, haemodialysis, toxicity to various agents. Methotrexate dosage: NA.
Multiple prescriptions taken:
  • Omeprazole
  • Omeprazole
  • Dexamethasone
The patient was hospitalized. These side effects may potentially be related to Methotrexate.
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DISCLAIMER: ALL DATA PROVIDED AS-IS, refer to terms of use for additional information.

Methotrexate Thrombocytopenia Causes and Reviews


Platelets are little pieces of blood cells. Platelets help wounds heal and prevent bleeding by forming blood clots. Your bone marrow makes platelets. Problems can result from having too few or too many platelets, or from platelets that do not work properly.

If your blood has a low number of platelets, it is called Thrombocytopenia. This can put you at risk for mild to serious bleeding. If your blood has too many platelets, you may have a higher risk of blood clots. With other platelet disorders, the platelets do not work as they should. For example, in von Willebrand Disease, the platelets cannot stick together or cannot attach to blood vessel walls. This can cause excessive bleeding.

Treatment of platelet disorders depends on the cause.

NIH: National Heart, Lung, and Blood Institute


Methotrexate Thrombocytopenia Reviews

Mon, 21 Feb 2011

My 27 years of MTX therapy have prevented physical deformity but caused me to have damage to my lungs. I am short of breath on any activity. MTX helped the pain somewhat but at the cost of my lungs? I was never told about this possibility nor told it ultimately RA could be fatal. I am only in my 50's not ready to die yet!

Sat, 26 Oct 2013

has anybody had any positive affects from taking " Methoblastin " (Methotrexate) for psoaratic arthritis ? these reviews sound terrible and i have been told to go on it... im a little scared now :(

Sun, 15 May 2011

I have been on Methotrexate for almost months and last two weeks have had severe pains at times lower back , It feel like the kidneys because one side hurts at times and in the mornings it is worse. I am 3 days shy of talking another blood test. Is there anything I can do other than drink a lot of water. Thank you

Sat, 20 Dec 2008
Hi I haven't had any side effects for the past six years of Methotrexate. but recently I am having some stomach discomfort like as soon as i eat something i have the slight discomfort on my abdoman. I take a glass of green leaf juice and i am fine again. I would want to know if I should reduce the dose.
Sun, 24 Jan 2010
I just started Methotrexate, I started itching in the same areas where I had experienced itching with the chicken pox 2 years ago. I am a 51 year old female who contracted chicken pox at 49 years old. This frightens me as I know this can cause disseminated herpes which can be potentially fatal. My Rheum told me to take Benadryl. I believe this is going to be my one and only shot this drug scares the death out of me.
Tue, 27 Apr 2010
painful cough after 2 days of 1st dose lasting-- to date-- 6 days
Thu, 27 May 2010
I am 60 Years of age. 8 years ago i was falsely diagnosed with Rheumatoid Arthritis, i was started on Methoblastin 5Mg a week, Was not given Folic Acid and Ranitidine within the 5 months of taking the tablets i developed exposed blood vessels and spots, Stomach pains, reflux, Unable to properly swollow food, confussion, memmory loss, anxiety attacks, nightmares, hard on sleeping, high fevers, diahria, halusanations, itching, dry skin, mouth and eyes, coughin, sore tendons etc.. After i had stoped taking it, specialist said the side effects would go away. The side effects have never gone.. I try to controll it by taking Folic Acid 1mg a day, Glusamine (Joint food). 3 days a week i will take a small amount of Milk Thistle. Too much of Milk thistle would cause Mood swings and Constipation. Doctors are no help.
Sat, 18 Sep 2010
im a 44yrs old female who took Methotrexate for 2yrs with excellent results and no side effects but had to stop taking it when it started lowering my white cells.
DISCLAIMER: ALL DATA PROVIDED AS-IS, refer to terms of use for additional information.

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Top Methotrexate Side Effects

Pyrexia (411)
Pancytopenia (356)
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Headache (269)
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Renal Failure (118)
Hypertension (115)
Weight Decreased (114)
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Fall (103)
Infection (103)
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Hypotension (95)
Nasopharyngitis (93)
Paraesthesia (93)
Septic Shock (91)

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