Modafinil – Interesting Facts

Modafinil – Interesting Facts
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Brand/Commercial Names


Modafinil is used to treat excessive sleepiness caused by narcolepsy (a condition that causes excessive daytime sleepiness) or shift work sleep disorder (sleepiness during scheduled waking hours and difficulty falling asleep or staying asleep during scheduled sleeping hours in people who work at night or on rotating shifts). Modafinil is also used along with breathing devices or other treatments to prevent excessive sleepiness caused by obstructive sleep apnea/hypopnea syndrome (OSAHS; a sleep disorder in which the patient briefly stops breathing or breathes shallowly many times during sleep and therefore doesn’t get enough restful sleep). Modafinil is in a class of medications called wakefulness promoting agents. It works by changing the amounts of certain natural substances in the area of the brain that controls sleep and wakefulness.


Active Ingredient(s)

Chemically and Mechanistically Related Drugs
Adrafinil or Modafinil to give you more energy and vitality, you might be curious as to what the main differences between these smart drugs are. These are two of the most popular cognitive enhancement drugs available today with considerable benefits recorded for speed of cognition, memory, productivity and general alertness.
The original clinical purpose of Adrafinil was to help those who have sleep problems.
Many users also seem to experience a higher level of energy from this supplement. This is most likely due to the fact that it works by increasing the presence of the neurotransmitter Hypocretin. This brain chemical actually controls how alert and awake a person will feel.
Mood is also generally improved while using Adrafinil. This is caused by an increase in the levels of Dopamine and Serotonin within the brain.
Adrafinil is also capable of stimulating Glutamate receptors in the brain. As Glutamate receptors are stimulated and their pathways activated, this supplement increases memory and may also improve the speed of recall.
Ritalin is a controlled substance under the Misuse of Drugs act, the spokesperson says. Possession of it without a prescription is illegal and it is a Class B drug.

Pediatric Use
Provigil is not approved for use in children for any medical condition. It is not known if Provigil is safe or effective in children under 17 years of age.

Use in the Elderly
Although appropriate studies on the relationship of age to the effects of Modafinil have not been performed in the geriatric population, geriatric-specific problems are not expected to limit the usefulness of Modafinil in the elderly. However, elderly patients may have a slower removal of this medicine from the body, which may require an adjustment in the dose for patients receiving Modafinil.

Worldwide Sales
Q3 2013 sales: $176,996,000

Interesting Fact(s)
Modafinil is a stimulant in the same vein as caffeine and adenosine, but the difference in how it works the brain means it doesn’t have the same side-effects that the others do.
The way caffeine and Adenosine work is that they block certain receptors in the brain that react to dopamine, which makes it slow down. This means, for example, that coffee does not give you energy, but rather, doesn’t let the brain realize it needs more energy. This is why people crash after caffeine. The effect goes away and all the tiredness catches up to you. Modafinil doesn’t have that problem.
No one really knows how it works yet, but it seems that instead of blocking the brain’s Dopamine processing, it just slows production of Dopamine. On top of that, it also prevents the re-uptake of another neurotransmitter called noradrenaline, which triggers sleep.
The end result, and one of the most mysterious, is that Modafinil doesn’t trigger sleep debt. People who stay awake for a day or two on Modafinil don’t report a need to catch up on sleep after the effect wears off. They can sleep the normal amount!

Posted in Side Effects

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