CEPHALEXIN Capsule [Ascend Laboratories, LLC]

Updated Date: Feb 10, 2014 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

CEPHALEXIN Powder, For Suspension [MedVantx, Inc.]

Updated Date: Feb 3, 2014 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

Pharmaceutical salts and cocrystals involving amino acids: A brief structural overview of the state-of-art.

Authors: Tilborg A, Norberg B, Wouters J Abstract Salification of new drug substances in order to improve physico-chemical or solid-state properties (e.g. dissolution rate or solubility, appropriate workup process, storage for further industrial and marketing development) is a well-accepted procedure. Amino acids, like aspartic acid, lysine or arginine take a great part in this process and are implicated in several different formulations of therapeutic agent families, including antibiotics (amoxicillin from beta lactam class or cephalexin from cephalosporin class), NSAIDs (ketoprofen, ibuprofen and naproxen from profen family, acetylsalicylic acid) or antiarrhythmic agents (e.g. ajmaline). Even if more than a half of known pharmaceutical molecules possess a salifiable moiety, what ...

CEPHALEXIN Powder, For Suspension [Preferred Pharmaceuticals, Inc.]

Updated Date: Dec 27, 2013 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

Septic Arthritis Due to Moraxella osloensis in a Rhesus Macaque (Macaca mulatta).

Authors: Wren MA, Caskey JR, Liu DX, Embers ME Abstract A 5.5-y-old Chinese-origin female rhesus macaque (Macaca mulatta) presented for bilateral hindlimb lameness. The primate had been group-reared in an SPF breeding colony and was seronegative for Macacine herpesvirus 1, SIV, simian retrovirus type D, and simian T-lymphotropic virus. The macaque's previous medical history included multiple occasions of swelling in the left tarsus, and trauma to the right arm and bilateral hands. In addition, the macaque had experienced osteomyelitis of the left distal tibia and rupture of the right cranial cruciate ligament that had been surgically repaired. Abnormal physical examination findings on presentation included a thin body condition, mild dehydration, and bilaterally swollen stifles tha...<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>

Glucose-dependent insulinotropic polypeptide regulates dipeptide absorption in mouse jejunum

Glucose-dependent insulinotropic polypeptide (GIP) secreted from jejunal mucosal K cells augments insulin secretion and plays a critical role in the pathogenesis of obesity and Type 2 diabetes mellitus. In recent studies, we have shown GIP directly activates Na-glucose cotransporter-1 (SGLT1) and enhances glucose absorption in mouse jejunum. It is not known whether GIP would also regulate other intestinal nutrient absorptive processes. The present study investigated the effect of GIP on proton-peptide cotransporter-1 (PepT1) that mediates di- and tripeptide absorption as well as peptidomimetic drugs. Immunohistochemistry studies localized both GIP receptor (GIPR) and PepT1 proteins on the basolateral and apical membranes of normal mouse jejunum, respectively. Anti-GIPR antibody detected 50...

Antibiotics for methicillin-resistant Staphylococcus aureus skin and soft tissue infections: the challenge of outpatient therapy

Conclusion: Methicillin-resistant Staphylococcus aureus is a particularly virulent, rapidly adaptive pathogen that is becoming increasingly difficult to combat with existing antibiotics. Care must be taken to ensure appropriate treatment and follow-up of patients with known MRSA infections. (Source: The American Journal of Emergency Medicine)

4�Aminoquinoline�β�Lactam Conjugates: Synthesis, Antimalarial, and Antitubercular Evaluation

A library of quinoline�β�lactam�based hybrids was synthesized and tested for their antimalarial and antitubercular activities. The present antimalarial data showed the dependence of activity on the nature of linker, N�1 substituent of the β�lactam ring as well as the length of alkyl chain. Most of the compounds are not as efficient as chloroquine in inhibiting the culture growth of Plasmodium falciparum W2 strain. Nevertheless, the synthesized hybrids showed better antitubercular activities (up to five times) compared with cephalexin (up to three times) and ethionamide. Thirty four 4�aminoquinoline�β�lactam conjugates have been synthesized and evaluated for their antimalarial and anti�TB profiles. (Source: Chemical Biology and Drug Design)

Registered nurse assessment and treatment of skin sepsis in New Zealand schools: the development of protocols.

CONCLUSION: Robust evidence to determine optimal choice, dosage and duration of antibiotic therapy for skin sepsis in children is lacking. The algorithms described are consistent with available evidence and provide a pragmatic approach for use in registered nurse (RN)-led school clinics. PMID: 24126747 [PubMed - in process] (Source: Bulletin of the World Health Organization)

Oral Antibiotics Versus Topical Decolonization to Prevent Surgical Site Infection After Mohs Micrographic Surgeryâ??a Randomized, Controlled Trial

ConclusionIn patients with demonstrable carriage of S. aureus, topical decolonization resulted in fewer SSI than in patients receiving perioperative oral antibiotics. Antibiotics should be reserved for clinically suspected and swab�proven infections rather than being prescribed empirically. Further efforts should be directed toward optimizing endogenous risk factor control for all patients presenting for MMS. (Source: Dermatologic Surgery)<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>

Glucose-dependent Insulinotropic Polypeptide (GIP) Regulates Dipeptide Absorption in Mouse Jejunum.

Authors: Coon SD, Schwartz JH, Rajendran VM, Jepeal LI, Singh SK Abstract Glucose-dependent insulinotropic polypeptide (GIP), which is released into the circulation from jejunal mucosal K-cells. Circulating GIP augments pancreatic insulin secretion and hyperinsulinemia plays critical roles in the pathogenesis of obesity and type-2 diabetes mellitus. In recent studies, we have shown GIP directly activates Na-glucose co-transporter-1 (SGLT1) and enhances glucose absorption in mouse jejunum. It is not known whether GIP would also regulates other intestinal nutrient absorptive process(es). Present study investigated the effect of GIP on H(+)-peptide cotransporter-1 (PepT1) that mediates di- and tripeptides as well as peptidomimetic drugs. The activity of PepT1 is driven by a proton (H(...

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