A novel ketolide RBx 14255 with activity against multi-drug resistant Streptococcus pneumoniae.

We present a novel ketolide RBx14255, a semi-synthetic macrolide derivative obtained by derivatization of clarithromycin, for its in vitro and in vivo activity against sensitive and macrolide-resistant S. pneumoniae. RBx 14255 showed excellent in vitro activity against macrolide-resistant S. pneumoniae including in-house generated telithromycin-resistant strain (S. pneumoniae 3390 NDDR). RBx 14255 showed potent protein synthesis inhibition against telithromycin-resistant S. pneumoniae 3390 NDDR. The binding affinity of RBx 14255 towards ribosome was found to be more than other tested drugs. The in vivo efficacy of RBx 14255 was determined in murine pulmonary infection induced by intranasal inoculation of S. pneumoniae ATCC 6303 and systemic infection of S. pneumoniae 3390 NDDR strains. The...

Pharmacokinetic evaluation of the interaction between etravirine and rifabutin or clarithromycin in HIV-negative, healthy volunteers: results from two Phase 1 studies

Conclusions Short-term etravirine coadministration with rifabutin or clarithromycin was well tolerated. Etravirine can be coadministered with 300 mg of rifabutin once daily in the absence of an additional potent cytochrome P450 inducer. No dose adjustments are required upon etravirine/clarithromycin coadministration, but alternatives to clarithromycin are recommended when used for Mycobacterium avium complex prophylaxis or treatment. (Source: Journal of Antimicrobial Chemotherapy)

Short-term use of clarithromycin in lower respiratory tract infections may increase long-term risk of cardiovascular mortality and morbidity

This study evaluated the association between clarithromycin use and cardiovascular events in patients treated for lower respiratory tract infections in a secondary analysis of two prospective cohort studies. The EXODUS dataset enrolled 1343 patients aged over 40 admitted with COPD exacerbations to 12 hospitals in the UK from 2009 to 2011. The Edinburgh pneumonia cohort included 1631 patients admitted to hospital with radiologically confirmed community-acquired pneumonia from 2005 to 2009. Both datasets were reviewed for cardiovascular events at 1 year (defined as hospital admission for acute coronary syndrome, decompensated cardiac failure, serious arrhythmia or sudden cardiac death). There were 268 events in the COPD cohort and 171 in the... (Source: Thorax)

Triple Therapy with High‚?źDose Proton‚?źPump Inhibitor, Amoxicillin, and Doxycycline Is Useless for Helicobacter pylori Eradication: A Proof‚?źof‚?źConcept Study

ConclusionsAlthough safe, a triple‚?źtherapy protocol with high‚?źdose PPI, amoxicillin, and doxycycline is useless for multidrug‚?źresistant H.¬†pylori eradication. (Source: Helicobacter)

CLARITHROMYCIN Tablet, Film Coated [Mylan Pharmaceuticals Inc.]

Updated Date: Jan 27, 2014 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>

CLARITHROMYCIN Tablet, Film Coated CLARITHROMYCIN Tablet, Film Coated, Extended Release CLARITHROMYCIN For Suspension [Zydus Pharmaceuticals USA Inc]

Updated Date: Jan 23, 2014 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

Temporal decrease in overall antibiotic consumption accompanying antibiotic prescribing rate disclosure policy: evidence from analysis of national health insurance claims data in South Korea.

Authors: Lee YS, Kwon JW, Oh OH, Sohn HS Abstract The health insurance review and assessment services, responsible for the assessment of quality and quantity of healthcare providers' services, implemented a public disclosure policy for antibiotic prescribing rate in February 2006. The aim of this study was to investigate changes of overall antibiotic consumption following the policy by analysing national healthcare utilization data from 2005 to 2009. Prescription information of systemic antibiotics excluding antifungals and topical antibiotics was retrospectively collected from the population-based health insurance claims sample data for the five years from 2005 to 2009. Those data were analysed using the standardised anatomical therapeutic chemical/defined daily dose method. Antib...

Macrolide/Azalide Therapy for Nodular/Bronchiectatic: Mycobacterium avium Complex Lung Disease.

CONCLUSIONS: Current guidelines for macrolide/azalide-based therapies for NB MAC lung disease result in favorable microbiological outcomes for most patients without promotion of macrolide resistance. Intermittent therapy is effective and significantly better tolerated than daily therapy. Microbiologic recurrences during or after therapy are common and due most often to reinfection MAC genotypes. PMID: 24457542 [PubMed - as supplied by publisher] (Source: Chest)

CLARITHROMYCIN Tablet, Coated [Roxane Laboratories, Inc]

Updated Date: Jan 10, 2014 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

Clarithromycin Induced Psoriasis in a 37-Year Old Man.

We report an exceptional case of psoriasis vulgaris probably induced by clarithromycin. A 37-year-old man was prescribed for pharyngitis clarithromycin 500mg twice a day. On the third day of treatment, he presented a non pruriginous erythemato-squamous eruption, of trunk and limbs. Skin biopsy showed a typical aspect of psoriasis vulgaris. The drug was interrupted and the patient was treated by topical corticoids with rapid improvement. PMID: 24410388 [PubMed - as supplied by publisher] (Source: Current Drug Safety)<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>

CLARITHROMYCIN Tablet, Film Coated [Aidarex Pharmaceuticals LLC]

Updated Date: Jan 2, 2014 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

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