Can interchangeability of lincosamides be assumed in clinical practice? Comparative MICs of clindamycin and lincomycin for Streptococcus pyogenes, Streptococcus agalactiae and Staphylococcus aureus

(Source: Journal of Antimicrobial Chemotherapy)

Relationship Between the Severity of Acne Vulgaris and Antimicrobial Resistance of Bacteria Isolated from Acne Lesions in a Hospital of Japan.

Authors: Nakase K, Nakaminami H, Takenaka Y, Hayashi N, Kawashima M, Noguchi N Abstract Propionibacterium acnes and Staphylococcus epidermidis are normal skin inhabitants that are frequently isolated from lesions caused by acne, and these microorganisms are considered to contribute to the inflammation of acne. In the present study, we examined the antimicrobial susceptibilities and resistance mechanisms of P. acnes and S. epidermidis that were isolated from patients with acne vulgaris in a university hospital in Japan from 2009 to 2010. Additionally, we analysed the relationship between the antimicrobial resistance of P. acnes and the severity of acne vulgaris. Some P. acnes strains (18.8% (13/69)) were resistant to clindamycin. All strains had a mutation in the 23S rRNA gene, exce...

Is Clostridium difficile associated with the ‚??4C‚?? antibiotics? A retrospective observational study in diabetic foot ulcer patients

ConclusionsLarge doses, numbers and greater duration of antibiotic therapy all result in a greater degree of normal gut flora depletion. It is possible that the alterations in gut flora in diabetic foot ulcer patients protect them from antibiotic‚?�induced C. difficile overgrowth. (Source: International Journal of Clinical Practice)

CLINDAMYCIN PHOSPHATE Cream [Greenstone LLC]

Updated Date: Jan 28, 2014 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

The application of quantitative NMR for the facile, rapid and reliable determination of clindamycin phosphate in a conventional tablet formulation.

Authors: Liang X, Du L, Su F, Parekh HS, Su W Abstract Spectroscopic tools such as NMR can be applied to the quantitative analysis of active pharmaceutical ingredients with relative ease and accuracy. Here, we demonstrate the quantification of clindamycin phosphate (CLP) in a conventional tablet formulation, performed using potassium hydrogen phthalate (KHP) as the internal standard and deuterium oxide (D2 O) as the NMR solvent. The methyl protons signal of CLP at 0.72‚??ppm (triplet) relative to the signal of KHP at 7.37-7.40‚??ppm (multiplet) was used for quantification purposes using (1) H NMR. This method was shown to be specific and linear (r‚??=‚??0.9997) within the CLP concentration range from 7.2 to 23.1‚??mg per 0.5‚??ml of D2 O. The maximum relative standard deviation (RS...<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>

CLINDAMYCIN HYDROCHLORIDE Capsule [Greenstone LLC]

Updated Date: Jan 24, 2014 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

CLINDAMYCIN PHOSPHATE Solution CLINDAMYCIN PHOSPHATE Lotion CLINDAMYCIN PHOSPHATE Gel [Greenstone LLC]

Updated Date: Jan 24, 2014 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

Prevalence, Serotype Identification by Multiplex Polymerase Chain Reaction and Antimicrobial Resistance Patterns of Listeria Monocytogenes Isolated from Retail Foods

This study focused on the prevalence of L.‚??monocytogenes in different raw and ready‚?�to‚?�eat foodstuffs, and serotype distribution among the isolates. Antibiotic resistance profiles of the isolates were also reported. Information and relief provided to consumers could help elaborate public health and food safety. (Source: Journal of Food Safety)

Mandibular Fracture-Induced Osteoradionecrosis

Osteoradionecrosis is the collateral effect of radiotherapy in the head and neck and is of great clinical significance. A¬ case of mandibular fracture-induced osteoradionecrosis was¬ reported. Man, 52, sought dental care with a history of oral cancer and radiotherapy. Examination revealed extraoral fistula in the left jaw, limited mouth opening, and an area of intraoral exposed bone. The clinical diagnosis was osteoradionecrosis. The panoramic radiograph revealed fracture of the left mandibular body. Clindamycin plus daily mouthwash with chlorhexidine gluconate 0.12% for 15 days was prescribed, resulting in the closure of intraoral and extraoral fistulae. The mandibular fracture remains, with the patient awaiting further intervention. We highlight the importance of integration between medi...

Radiography-based score indicative for the pathogenicity of bacteria in odontogenic infections.

Conclusions. The radiography-based score suggests that certain Prevotella spp., F. nucleatum and Strep. anginosus groups play a crucial role in the pathogenesis of odontogenic abscesses, and that various streptococci, Neisseria spp., Capnocytophaga spp., Staph. aureus and Prevotella spp. are involved in the pathogenesis of odontogenic infiltrates. PMID: 24444257 [PubMed - as supplied by publisher] (Source: Acta Odontologica Scandinavica)<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>

CLINDAMED (Clindamycin) Liquid [Bimeda, Inc., Division Of Cross Vetpharm Group]

Updated Date: Jan 17, 2014 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

Antimicrobial susceptibility of Ureaplasma urealyticum and Mycoplasma hominis

This study was conducted at the Department for Urogenital Infections and Sexually Transmitted Diseases, University Hospital for Infectious Diseases &lsquo;Dr Fran Mihaljevic&rsquo; Zagreb, Croatia, during the years 2010 and 2011. The study included a total of 544 positive isolates with &ge;104 CCU (Colour Changing Units) detected in female or male patients older than 18&nbsp;years. There were a total of 37 specimens positive for M hominis, and 507 positive... (Source: Sexually Transmitted Infections)

Acute localised exanthematous pustulosis (ALEP) induced by clindamycin in pregnancy

We describe a case of ALEP triggered by oral clindamycin that occurred during pregnancy. (Source: Australasian Journal of Dermatology)

CLINDAMYCIN HYDROCHLORIDE Capsule [American Health Packaging]

Updated Date: Jan 14, 2014 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

Acute localised exanthematous pustulosis (ALEP) induced by clindamycin in pregnancy.

We describe a case of ALEP triggered by oral clindamycin that occurred during pregnancy. PMID: 24417617 [PubMed - as supplied by publisher] (Source: The Australasian Journal of Dermatology)<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>

Successful treatment of simulated Clostridium difficile infection in a human gut model by fidaxomicin first line and after vancomycin or metronidazole failure

Conclusions Fidaxomicin successfully treated simulated primary and recurrent CDI. Fidaxomicin was superior to metronidazole in reducing CD TVC and SP, and superior to vancomycin in reducing SP without recurrence of vegetative cell growth. Fidaxomicin, but not vancomycin or metronidazole, persisted in the gut model for &gt;20 days after instillation. (Source: Journal of Antimicrobial Chemotherapy)

In vivo efficacy of ceftaroline fosamil in a methicillin-resistant pvl-producing staphylococcus aureus rabbit pneumonia model.

Conclusions: Ceftaroline fosamil, clindamycin, and to a lesser extent linezolid, were efficient in reducing bacterial titers in both the lungs and spleen and decreasing macroscopic score and PVL production compared with control. PMID: 24395236 [PubMed - as supplied by publisher] (Source: Antimicrobial Agents and Chemotherapy)

Prevalence of inducible clindamycin resistance among community-associated staphylococcal isolates in central Serbia

AD Aleksandra, MS Misic, ZV Mira, NM Violeta, IT Dragana, BM Zoran, VS Dejan, SD Milanko, BD DejanIndian Journal of Medical Microbiology 2014 32(1):49-52The emergence of resistance to most antimicrobial agents in staphylococci indicates the need for new effective agents in the treatment of staphylococcal infections. Clindamycin is considered to be one safe, effective and less costly agent. We analysed 482 staphylococcal isolates. Detection of inducible clindamycin resistance was performed by the D-test, while the presence of methylases genes: erm (A), erm (B) and erm (C), as well as, macrolide efflux gene mef was determined by polymerase chain reaction. Inducible clindamycin resistance phenotype was significantly higher in Staphylococcus aureus (S. aureus) strains then in coagulase-negativ...

CLINDAMYCIN HYDROCHLORIDE Capsule [Aidarex Pharmaceuticals LLC]

Updated Date: Jan 2, 2014 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

Rhabdomyolysis as a manifestation of clomipramine poisoning.

CONCLUSIONS: Although arrhythmia is the most important complication, rhabdomyolysis should be investigated in cases of clomipramine poisoning. PMID: 24346784 [PubMed - in process] (Source: Sao Paulo Medical Journal)<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>

Commensal Streptococcus agalactiae isolated from patients seen at University Hospital of Londrina, Parana, Brazil: capsular types, genotyping, antimicrobial susceptibility and virulence determinants

Conclusions: Our results indicate the potential virulence of commensal GBS isolates, reinforcing the need for continued screening for this bacterium to prevent infections. The distribution of capsular and pili antigens, and MLVA profiles was also identified, which may contribute to the development of new strategies for the prevention and treatment of GBS infection. (Source: BMC Microbiology - Latest articles)

Commensal Streptococcus agalactiae isolated from patients seen at University Hospital of Londrina, Paran√°, Brazil: capsular types, genotyping, antimicrobial susceptibility and virulence determinants

Conclusions: Our results indicate the potential virulence of commensal GBS isolates, reinforcing the need for continued screening for this bacterium to prevent infections. The distribution of capsular and pili antigens, and MLVA profiles was also identified, which may contribute to the development of new strategies for the prevention and treatment of GBS infection. (Source: BMC Microbiology - Latest articles)

The effect of high dose antibiotic impregnated cement on rate of surgical site infection after hip hemiarthroplasty for fractured neck of femur: a protocol for a double-blind quasi randomised controlled trial

DiscussionLarge randomised controlled trials assessing the effectiveness of a surgical intervention are uncommon, particularly in the speciality of orthopaedics. The results from this trial will inform evidence-based recommendations for antibiotic impregnated cement in the management of patients with a fractured neck of femur undergoing a hip hemiarthroplasty. If high dose antibiotic impregnated cement is found to be an effective intervention, implementation into clinical practice could improve long-term outcomes for patients undergoing hip hemiarthroplasty.Trial registration: Current Controlled Trials: ISRCTN25633145 (Source: BioMed Central)

CLINDAGEL (Clindamycin Phosphate) Gel [Galderma Laboratories, L.P.]

Updated Date: Dec 17, 2013 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

Trends in Antibiotic Resistance in Coagulase Negative Staphylococci, United States, 1999--2012.

Authors: May L, Klein EY, Rothman RE, Laxminarayan R Abstract Coagulase-negative staphylococci (CoNS) are important bloodstream pathogens typically resistant to multiple antibiotics. Despite concern about increasing resistance, there have been no recent studies describing the national prevalence in CoNS pathogens. We used national resistance data over a period of 13 years (1999-2012) from The Surveillance Network (TSN) to determine prevalence and assess trends in resistance for S. epidermidis, the most common CoNS pathogen, as well as all CoNS pathogens. Over the course of the study period, S. epidermidis resistance to ciprofloxacin and clindamycin increased steadily from 58.3% to 68.4% and from 43.4% to 48.5%, respectively. Resistance to levofloxacin increased rapidly from 57.1% i...<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>

Treatment of hidradenitis supprurativa associated pain with nonsteroidal anti-inflammatory drugs, acetaminophen, celecoxib, gabapentin, pegabalin, duloxetine, and venlafaxine.

Authors: Scheinfeld N Abstract Hidradenitis Supprurativa is a painful dermatological condition. Although the pain of HS has unique aspects, the pain of HS pain shares common elements with essential pain, fibromyalgia, and pure neuropathic pain syndromes. Futhermore, depression plays an important role in the pain of HS. This paper reviews the potential for use of nonsteroidal anti-inflammatory drug (NSAIDS), acetaminophen, celecoxib, gabpentin, pregabalin, and the serotonin and norepinephrine reuptake inhibitors (SNRIs), duloxetine and venlafaxine, for treating HS related pain. No studies exist for pain control in HS. Initially, the pain of HS is treated medically e.g. oral rifampin and clindamycin or adalimumab to decrease inflammation, but an analysis of pain medications to treat ...

Fourth Belgian multicentre survey of antibiotic susceptibility of anaerobic bacteria

Conclusions Compared with previous surveys, little evolution was seen in susceptibility, except a decline in activity of clindamycin against Prevotella spp. and other Gram-negative bacteria, and of moxifloxacin against clostridia. Since resistance was detected to all antibiotics, susceptibility testing of anaerobic isolates is indicated in severe infections to confirm appropriateness of antimicrobial therapy. (Source: Journal of Antimicrobial Chemotherapy)

Molecular analysis and distribution of multidrug-resistant Enterococcus faecium isolates belonging to clonal complex 17 in a tertiary care center in Mexico City

Conclusion: This study provides the first report of multidrug-resistant VREF isolates belonging to clonal complex 17 from a tertiary care center in Mexico City. Multidrug resistance and genetic determinants of virulence confer advantages among VREF in the colonization of their host. Therefore, the prevention and control of the spread of nosocomial infections caused by VREF is crucial for identifying new emergent subclones that could be challenging to treat in subsequent years. (Source: BMC Microbiology - Latest articles)

Propionibacterium acnes: An Underestimated Pathogen in Implant-Associated Infections.

Authors: Portillo ME, Corvec S, Borens O, Trampuz A Abstract The role of Propionibacterium acnes in acne and in a wide range of inflammatory diseases is well established. However, P. acnes is also responsible for infections involving implants. Prolonged aerobic and anaerobic agar cultures for 14 days and broth cultures increase the detection rate. In this paper, we review the pathogenic role of P. acnes in implant-associated infections such as prosthetic joints, cardiac devices, breast implants, intraocular lenses, neurosurgical devices, and spine implants. The management of severe infections caused by P. acnes involves a combination of antimicrobial and surgical treatment (often removal of the device). Intravenous penicillin G and ceftriaxone are the first choice for serious infec...

Failure of Clindamycin to Eradicate Infection with Beta-Hemolytic Streptococci Inducibly Resistant to Clindamycin in an Animal Model and in Human Infections.

Conclusions:We have demonstrated in a murine model of infection and from human cases inducible clindamycin resistance in ő≤-hemolytic streptococci is clinically significant. Routine testing and reporting by clinical laboratories should be encouraged and alternative antimicrobial agents considered when these organisms are encountered in clinical care. PMID: 24323478 [PubMed - as supplied by publisher] (Source: Antimicrobial Agents and Chemotherapy)<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>

Determination of clindamycin and its metabolite clindamycin sulfoxide in diverse sewage samples.

Authors: Oertel R, Schubert S, M√ľhlbauer V, B√ľttner B, Marx C, Kirch W Abstract In a research project on risk management of harmful substances in water cycles, clindamycin and 12 further antibiotics were determined in different sewage samples. In contrast to other antibiotics, an increase of the clindamycin concentration in the final effluent in comparison to the influent of the sewage treatment plant (STP) was observed. A back transformation from the main metabolite clindamycin sulfoxide to clindamycin during the denitrification process has been discussed. Therefore, the concentration of this metabolite was measured additionally. Clindamycin sulfoxide was stable in the STP and the assumption of back transformation of the metabolite to clindamycin was confuted. To explain the inc...

Comparison of Sensititre microdilution method to other standard methods for susceptibility testing of coagulase-negative staphylococci from paediatric blood cultures

Abstract: Susceptibility testing on 60 isolates of Staphylococcus epidermidis and 20 isolates of Staphylococcus hominis was performed using the Sensititre (Trek Diagnostics, Cleveland, OH, USA) method and compared with Vitek-2 automated susceptibility testing (bioMèrieux, Marcy l'Etoile, France), MICE strips for minimum inhibitory concentration determination (Oxoid, Basingstoke, UK), and disc diffusion (MAST, Bootle, UK). The categorical agreement between Vitek and Sensititre was greater than 90% for agents tested against S. epidermidis except for tetracycline (52%) and oxacillin (67%), and for S. hominis, the agreement was greater than 90% except for tetracycline (80%), gentamicin (65%), and oxacillin (75%). The categorical agreement between disc diffusion and Sensititre was greater than...

[Toxoplasma uveitis in a patient with ankylosing spondylitis].

Authors: Deveci H, Kobak S Abstract In this paper, a posterior uveitis case was reported in a patient who was being followed and under treatment for Ankylosing Spondylitis. Toxoplasma antibodies were investigated and anti-toxoplasma IgG was positive. Systematic treatment (Sulfamethoxazole/Trimethoprim and Clindamycin) was started. Despite medical treatment, reduction in visual acuity and development of dense membranous condensation in vitreous occurred. Surgical vitrectomy was performed. When posterior uveitis develops in patients who undergo immunosuppressive treatment, toxoplasma is among the first infectious agents that we should consider. A delay in diagnosis and treatment may result in failure in obtaining the desired outcome from medical treatment and a shift to surgical trea...

Inspiration from Old Dyes: Tris(stilbene) Compounds as Potent Gram-Positive Antibacterial Agents.

Prevalence of antibiotic resistance in US hospitals

Abstract: The percentage of isolates resistant to essential antibiotics among clinically significant bacterial pathogens was evaluated using data from 80089 qualifying admissions in 19 US hospitals (2007‚??2010). Percentage resistant was highest for the following pathogen/antibiotic pairs: Enterococcus faecium/vancomycin (87.1% [95% CI 86.0‚??88.1] of 4024 isolates), Staphylococcus aureus/oxacillin‚??methicillin (56.8% [56.1‚??57.4] of 23477 isolates), S. aureus/clindamycin (39.7% [39.1‚??40.4] of 21133 isolates), Pseudomonas aeruginosa/fluoroquinolones (32.6% [31.8‚??33.5] of 10982 isolates), and Escherichia coli/fluoroquinolones (31.3% [30.8‚??31.8] of 30715 isolates). The percentage resistant was 3.9% (3.2‚??4.9) for E. faecium/daptomycin (n = 2029 isolates). While these results are con...<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>

Antibiotics for methicillin-resistant Staphylococcus aureus skin and soft tissue infections: the challenge of outpatient therapy

Conclusion: Methicillin-resistant Staphylococcus aureus is a particularly virulent, rapidly adaptive pathogen that is becoming increasingly difficult to combat with existing antibiotics. Care must be taken to ensure appropriate treatment and follow-up of patients with known MRSA infections. (Source: The American Journal of Emergency Medicine)

Antibiogram, adhesive characteristics, and incidence of class 1 integron in Aeromonas species isolated from two South african rivers.

Authors: Igbinosa IH, Chigor VN, Igbinosa EO, Obi LC, Okoh AI Abstract Aeromonas species are well distributed in freshwater environments, and their natural susceptibility to antimicrobials renders them interesting candidates for the survey of antimicrobial resistance in freshwater milieu. Water samples were collected from Kat and Tyume rivers in the Eastern Cape province of South Africa, and a total of 45 isolates identified as Aeromonas species were recovered from the two rivers. All Aeromonas isolates were resistant to oxacillin, penicillin, clindamycin, cephalothin, vancomycin, and rifamycin, while appreciable susceptibilities (89.3‚??:‚??94.1%, 82.1‚??:‚??94.1%, 85.7‚??:‚??88.2%, and 92.9‚??:‚??88.2%) were observed against ciprofloxacin, chloramphenicol, nitrofurantoin, and gen...

Community-associated Clostridium difficile infection among older people in Tayside, Scotland, is associated with antibiotic exposure and care home residence: cohort study with nested case-control

Conclusions Our results have two important implications. First, they validate the classification of 4C antibiotics and fluoroquinolones in primary care as high risk for CA-CDI. Second, they demonstrate the importance of prior antibiotic exposure and place of residence for risk assessment by primary care prescribers. (Source: Journal of Antimicrobial Chemotherapy)

Healthcare associated infections caused by coagulase-negative Staphylococci in a neonatal intensive care unit

CONCLUSION: Coagulase-negative Staphylococci was the main agent identified in healthcare-associated infections, with low rates of infections related to central venous catheter. In hospitals with a high oxacillin resistance profile, similar to those included in this study, vancomycin may be used as an initial therapy, although clindamycin represents a viable alternative. (Source: Revista Brasileira de Terapia Intensiva)

Corynebacterium diphtheriae and the Returned Tropical Traveler

ConclusionThe majority of C. diphtheriae isolated were from SSIs in otherwise healthy travelers returning from tropical destinations, rather than classical risk groups. Clinicians and laboratories need to be aware of this potential source of C. diphtheriae infection due to rare toxigenic strains. (Source: Journal of Travel Medicine)<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>

Molecular Epidemiological Characteristics of Streptococcus pyogenes Strains Involved in an Outbreak of Scarlet Fever in China, 2011.

CONCLUSION: Several highly diversified clones with a high macrolide resistance rate comprise a predominant proportion of circulating strains, though no new emm type was found in this outbreak. The data provide a baseline for further surveillance of scarlet fever, which may contribute to the explanation of the outbreak and development of a GAS vaccine in China. PMID: 24331532 [PubMed - in process] (Source: Biomedical and Environmental Sciences : BES)

Pityriasis folliculorum: A novel therapy for a diagnostically challenging condition

To the Editor: A 26-year-old Caucasian man with recalcitrant rosacea presented with a 2-year history of persistent facial flushing, stinging, pruritus, blepharitis, pustules, and a ‚??sandpaper-like‚?� texture of his facial skin. He previously failed consecutive treatment with metronidazole 1% gel, clindamycin 1% gel, oral doxycycline 40 mg daily, Vbeam laser (Candela Corp, Wayland, MA), and isotretinoin 20 mg daily. His forehead and cheeks had multiple papulopustular lesions on a background of erythema. Most of his non‚??hair-bearing follicular orifices were noted to have minute, hyperkeratotic spicules protruding from their centers (). Potassium hydroxide microscopic examination of a pustule and the keratinous spicules revealed numerous Demodex mites. A¬ diagnosis of pityriasis folliculo...

Black-Boxed Drugs We Still Use: Weigh the Risk

The ‚??take home‚?� from this presentation: be cautious with inappropriate use of drugs with or without black box warnings, but maintain a healthy skepticism about some of these warnings. Cases in point: droperidol, antidepressants, clindamycin. (Source: Consultant Live)

Molecular and phenotypic evidence for the spread of three major methicillin-resistant Staphylococcus aureus clones associated with two characteristic antimicrobial resistance profiles in China

Conclusions The predominant MRSA clones in China were associated with characteristic antimicrobial resistance profiles. Antibiotics for treating patients with MRSA infections can be selected based on the strain typing data. (Source: Journal of Antimicrobial Chemotherapy)

Minocycline, often forgotten but preferred to trimethoprim‚??sulfamethoxazole or doxycycline for the treatment of community-acquired meticillin-resistant Staphylococcus aureus skin and soft-tissue infections

Abstract: Treatment of uncomplicated skin and soft-tissue abscesses caused by meticillin-sensitive Staphylococcus aureus or meticillin-resistant S. aureus (MRSA) is problematic. Incision and drainage aside, oral antibiotic therapy for uncomplicated community-acquired MRSA (CA-MRSA) is limited and frequent choices include clindamycin, doxycycline or trimethoprim‚??sulfamethoxazole (TMP‚??SMX). The most common oral antibiotics used for CA-MRSA are doxycycline or TMP‚??SMX, which often fail to eradicate the infection. With MRSA, in vitro susceptibilities do not always predict in vivo effectiveness. In situations where doxycycline or TMP‚??SMX fails in the treatment of uncomplicated cutaneous abscesses due to CA-MRSA, minocycline is reliably effective. (Source: International Journal of Antimic...<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>

Treatment of Infections Due to Resistant Staphylococcus aureus

This chapter reviews data on the treatment of infections caused by drug-resistant Staphylococcus aureus, particularly methicillin-resistant S. aureus (MRSA). This review covers findings reported in the English language medical literature up to January of 2013. Despite the emergence of resistant and multidrug-resistant S. aureus, we have seven effective drugs in clinical use for which little resistance has been observed: vancomycin, quinupristin&ndash;dalfopristin, linezolid, tigecycline, telavancin, ceftaroline, and daptomycin. However, vancomycin is less effective for infections with MRSA isolates that have a higher MIC within the susceptible range. Linezolid is probably the drug of choice for the treatment of complicated MRSA skin and soft tissue infections (SSTIs); whether it is drug of...

Epidemiology of Group B streptococcus Isolated from Pregnant Women in Beijing, China

This article is protected by copyright. All rights reserved. (Source: Clinical Microbiology and Infection)

The trend of macrolide resistance and emm types of group A streptococci from children at a medical center in southern Taiwan.

CONCLUSION: Increased resistance of GAS to macrolide and clindamycin was found in recent years. emm12 was the main serotype for macrolide resistance. PMID: 24094501 [PubMed - as supplied by publisher] (Source: Journal of Microbiology, Immunology, and Infection)

Prophylaxis and Treatment of Anthrax in Pregnant Women.

CONCLUSIONS:: Overall, safety and pharmacokinetic information is limited for these antimicrobials. Although small increases in risks for certain anomalies have been observed with some antimicrobials recommended for prophylaxis and treatment of anthrax, the absolute risk of these antimicrobials appears low. Given the high morbidity and mortality associated with anthrax, antimicrobials should be dosed appropriately to ensure that antibiotic levels can be achieved and sustained. Dosing adjustments may be necessary for the ő≤-lactam antimicrobials and the fluoroquinolones to achieve therapeutic levels in pregnant women. Data indicate that the ő≤-lactam antimicrobials, the fluoroquinolones, and, to a lesser extent, clindamycin enter the fetal compartment, an important consideration in the treat...

Systematic review on the rapidity of the onset of action of topical treatments in the therapy of mild‚?�to‚?�moderate acne vulgaris

ConclusionFurther research is needed to identify treatments that offer an early onset of action and to possible help to optimise patient's adherence. Acne trials should consider including TOA as an additional outcome.This article is protected by copyright. All rights reserved. (Source: British Journal of Dermatology)<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>

Impact of retreatment with an artemisinin-based combination on malaria incidence and its potential selection of resistant strains: study protocol for a randomized controlled clinical trial

Background: Artemisinin-based combination therapy is currently recommended by the World Health Organization as first-line treatment of uncomplicated malaria. Recommendations were adapted in 2010 regarding rescue treatment in case of treatment failure. Instead of quinine monotherapy, it should be combined with an antibiotic with antimalarial properties; alternatively, another artemisinin-based combination therapy may be used. However, for informing these policy changes, no clear evidence is yet available. The need to provide the policy makers with hard data on the appropriate rescue therapy is obvious. We hypothesize that the efficacy of the same artemisinin-based combination therapy used as rescue treatment is as efficacious as quinine + clindamycin or an alternative artemisinin-based comb...

Hidradenitis suppurativa: A practical review of possible medical treatments based on over 350 hidradenitis patients.

This article centers on medical therapies and will only passingly mention surgical and laser treatments. This article summarizes my treatment experience with over 350 HS patients. PMID: 24021361 [PubMed - in process] (Source: Dermatol Online J)

Antibiotic resistance in Prevotella species isolated from patients with cystic fibrosis

Conclusions This study profiles antibiotic susceptibility in Prevotella spp. in CF and demonstrates that meropenem, piperacillin/tazobactam, chloramphenicol and metronidazole are likely to be the most effective antibiotics if treatment is indicated. (Source: Journal of Antimicrobial Chemotherapy)

Antibiotic Resistance and Capacity for Biofilm Formation of Different Bacteria Isolated from Endodontic Infections Associated with Root-filled Teeth

Conclusions: These results suggest that the clinical significance of endodontic infections could include that they serve as a reservoir for antibiotic resistance. Furthermore, endodontic treatment should consider the adhesion and biofilm formation by a variety of bacteria. (Source: Journal of Endodontics)

Antibiotic stewardship program; contextual environment and framework

Conclusions There were recommendations on how to adopt the Antibiotic Stewardship and the suggested framework, as well as recommendations about data collection, analysis and measurements for future implementation of the Program. Specific steps were encouraged based on the exact results of specific antibiotics such as flouroquinolones, clindamycin, vancomycin and IV administration and conversion to oral antibiotics (Source: Journal of Epidemiology and Community Health)<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>

Molecular characterization and antibiotic resistance of clinical isolates of methicillin‚?�resistant Staphylococcus aureus obtained from Southeast of Iran (Kerman)

Staphylococcus aureus infections, particularly infections caused by methicillin‚?�resistant S. aureus (MRSA) strains, are emerging as a major public health problem. The aim of this study was to determine the prevalence of MRSA, antibiotic resistance profile and staphylococcal cassette chromosome mec (SCCmec) type of MRSA isolates obtained from clinical samples. Totally, 162 S. aureus isolates were obtained from clinical samples at three university hospitals in Kerman, Iran from March 2011 to February 2012. All isolates were identified as S. aureus by phenotypic methods and confirmed by PCR amplification of the nuc gene. MRSA isolates were screened by phenotypic tests and confirmed by presence of mecA gene. The minimum inhibitory concentrations (MICs) of the MRSA isolates against antibacter...

Two anthrax cases with soft tissue infection, severe oedema and sepsis in Danish heroin users

Conclusions: These two heroin-associated anthrax cases from Denmark corroborate that heroin contaminated with anthrax spores may be a continuous source of injectional anthrax across Europe. Clinicians and clinical microbiologists need to stay vigilant and suspect anthrax in patients with a history of heroin use who present with soft tissue or generalised infection. Marked swelling of affected soft tissue or unusual intra-abdominal oedema should strengthen clinical suspicion. (Source: BMC Infectious Diseases)

Community-associated Clostridium difficile infection and antibiotics: a meta-analysis

Conclusions Antibiotic exposure was an important risk factor for CA-CDI, but the risk was different amongst different antibiotic classes. The risk was greatest with clindamycin followed by fluoroquinolones and cephalosporins, whereas tetracyclines were not associated with an increased risk. (Source: Journal of Antimicrobial Chemotherapy)

Preparation and Characterization of Chitosan-Based Spray-Dried Microparticles for the Delivery of Clindamycin Phosphate to Periodontal Pockets.

Authors: Kń~+mn~lń~+mn~√ßarslan M, G√ľm√ľŇ?taŇ? M, Yń~+mn~ldń~+mn~z S, Baykara T Abstract Biodegradable spray-dried chitosan microparticles loaded with clindamycin phosphate (CDP) were formulated to deliver drugs locally into the periodontal pocket. The effects of spray dryer conditions, drug/polymer ratio, and added amounts of glutaraldehyde (GA) solution on the characterization of microparticles were investigated by determining process yield, encapsulation efficiency, particle size and size distribution, surface morphology, drug release, release kinetics, thermal analysis, and antimicrobial efficacy of formulations. Burst releasewas obtained for all formulations due to the water solubility of the drug, but the increased amount of chitosan decreased the drug release rates. Microparticles with a m...

Non-Toxigenic Clostridium difficile Protects Hamsters Against Challenge with Historic and Epidemic Toxigenic BI/NAP1/027 C. difficile.

Conclusion:NTCD colonization provides protection against challenge with toxigenic BI group strains. M3 is more effective than T7 in preventing CDI caused by the BI6 epidemic strain. Prevention of C. difficile infection caused by epidemic BI6 may be more challenging than for historic BI1 and non-BI C. difficile strains. PMID: 23939887 [PubMed - as supplied by publisher] (Source: Antimicrobial Agents and Chemotherapy)<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>

Clindamycin-Induced Acute Kidney Injury: Large Biopsy Case Series.

Authors: Xie H, Chen H, Hu Y, Xu S, He Q, Liu J, Hu W, Liu Z Abstract Background: While clindamycin-induced acute kidney injury (AKI) is uncommon, it has occurred more frequently in recent years. Summary: We investigated 24 patients diagnosed with clindamycin-induced AKI retrospectively. The dosage of clindamycin was 1.0-1.5 g/day. Fifteen patients had episodes of gross hematuria, but fever, skin rash and eosinophilia were rare. Urine analysis revealed mild proteinuria and severe tubular dysfunction. Twenty-three patients were diagnosed with AKI stage 3 upon admission. The clindamycin lymphocyte transformation assay was positive for 63.2% of the patients. Acute interstitial nephritis (AIN) and acute tubular necrosis (ATN) were proven by renal biopsy, and renal insufficiency appeare...

Reply by the Authors

The authors of the letter provide insightful comments regarding the effect of initial antibiotics on the outcomes of sepsis from Fournier's gangrene in our study. We analyzed 41 patients with Fournier's gangrene during an 8-year study period with the specific aims of identifying the causative pathogens and evaluating the antibiotic sensitivity and resistance patterns. The resistance patterns were compared with the currently recommended antibiotic regimens to evaluate their efficacy and provide insight into future antibiotic recommendations. The traditionally recommended empiric coverage of ceftriaxone, gentamycin, and clindamycin, together, adequately covered every pathogen cultured in our study, suggesting this combination was appropriate for the treatment of our patients. Additionally, s...

Ludwig's Angina Triaged as an Allergic Reaction

A 59-year-old female presented to an emergency dental clinic with dental pain and minor left buccal and mandibular swelling. She was found to have fractured tooth 18. She was given clindamycin and told to return in several days for extraction. Overnight, she was febrile to 102¬įF and the swelling worsened to include her tongue. Believing this to be an allergic reaction to the antibiotic, she presented to the emergency department the following morning. Her vitals were normal with SpO2 92% on room air. The physical examination revealed bilateral submental erythema extending to the anterior neck, a muffled voice, mild tongue elevation with firm, and tender brawny edema to the floor of the mouth (). Despite the swelling and erythema of her neck, her airway was stable (). Laboratory studies rev...

Efficacy of vitamin C vaginal tablets as prophylaxis for recurrent bacterial vaginosis: a randomised, double-blind, placebo-controlled clinical trial.

CONCLUSIONS: The study showed that regular use of 250 mg ascorbic acid vaginal tablets on 6 days per month for 6 months after successful treatment of bacterial vaginosis halves the risk of recurrence from 32.4% to 16.2% (P = 0.024). PMID: 23864922 [PubMed] (Source: Clin Med Res)

The microbiota battle.

Authors: Jones L Abstract Antibiotic prophylaxis for laboring women with the intent of protecting newborns from group B strep (GBS) infection carries substantial risks and ethical shortcomings. GBS has been proven to be developing resistance to erythromycin and clindamycin. We are now seeing evidence of its resistance to penicillin, the recommended drug used in the prophylactic protocol. Bacterial resistance to antibiotics is linked to increased virulence of the bacteria. Considering the fact that robust bacterial flora throughout the body is essential to the health and well-being of new mothers and the bacterial colonization of their babies, perhaps the prophylactic use of antibiotics needs to be reconsidered. PMID: 23847897 [PubMed - in process] (Source: Midwifery Today with ...<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>

The protective effect of recombinant Lactococcus lactis oral vaccine on a Clostridium difficile-infected animal model

Conclusion: Recombinant L. lactis live vaccine is effective for preventing CDI in the hamster model, thus providing an alternative for immunization of C. difficile-associated diseases. (Source: BMC Gastroenterology)

A Method for generating marker-less gene deletions in multidrug-resistant Acinetobacter baumannii

Conclusions: The marker-less gene deletion method using pMo130-TelR is applicable for creating single and multiple gene deletions in MDR A. baumannii. The adeFGH and adeIJK operons were successfully deleted separately and together using this method and the impact of each efflux pump on antimicrobial resistance could be defined clearly. (Source: BMC Microbiology - Latest articles)

Cleocin Vaginal Ovules (Clindamycin Phosphate Vaginal Suppositories) - updated on RxList

(Source: RxList - New and Updated Drug Monographs)

Trends in the antimicrobial susceptibilities and serotypes of Streptococcus pneumoniae: results from the Tigecycline In Vitro Surveillance in Taiwan (TIST) study, 2006‚??2010

Abstract: Isolates of Streptococcus pneumoniae (n=530) were collected from 20 hospitals in different parts of Taiwan from 2006 to 2010. MICs to 16 antimicrobial agents were determined by broth dilution method and serotypes were identified by latex agglutination. Based on meningitis (non-meningitis) criteria established by the CLSI, 11.7% (63.2%) of all isolates were susceptible to penicillin and 46.0% (83.8%) were susceptible to ceftriaxone. Of the isolates, 94.3% were non-susceptible to azithromycin and 5.8% and 7.2% were non-susceptible to moxifloxacin and levofloxacin, respectively. Susceptibility to penicillin by meningitis criteria increased significantly (P=0.0012) with year, and that to clindamycin and amoxicillin/clavulanic acid declined significantly (P (Source: International Jour...

A unique strain of community-acquired Clostridium Difficile in severe complicated infection and death of a young adult

Conclusions: We believe that clindamycin used for coverage of a dental abscess was an independent risk factor that initiated the disruption of the bowel micro-flora, resulting in overgrowth of Clostridium difficile NAP12/ribotype 087. This uncommon strain, which is the same ribotype (087) as ATCC 43255, was apparently responsible for the increased severity of the infection and death following toxic megacolon, bowel perforation and pseudomembranous colitis involving the entire large bowel. K. pneumoniae sepsis, resolved by antibiotic therapy was secondary to Clostridium difficile infection. The case registers community-acquired Clostridium difficile infection as producing serious complications similar to hospital-acquired Clostridium difficile infection and should be treated with the requis...<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>

Tigecycline induction of phenol-soluble modulins by invasive MRSA strains.

We examined the effects of tigecycline on three exoproteins, PSMő~+mn~1-4, ő~+mn~-hemolysin, and protein A, on 13 MRSA isolates compared to clindamycin and linezolid. Paradoxical increases of PSMő~+mn~s occurred in 77% of isolates with tigecycline at &frac14; and &frac18; MICs and clindamycin at &frac18; MIC compared to only 23% of isolates with linezolid at &frac18; MIC. Induction was specific to PSMő~+mn~1-4, as protein A and ő~+mn~-hemolysin production were decreased under the same conditions with all antibiotics. PMID: 23817369 [PubMed - as supplied by publisher] (Source: Antimicrobial Agents and Chemotherapy)

Serious group a streptococcal infections.

Authors: Wong CJ, Stevens DL Abstract The spectrum of illnesses caused by group A streptococcus (GAS) includes invasive infections, noninvasive infections, and noninfectious complications. Increasingly virulent infections associated with high morbidity and mortality have been observed since the late 1980s and continue to be prevalent in North America and worldwide. Penicillin remains the therapy of choice, with the addition of clindamycin recommended in high risk cases. Early recognition of GAS as the cause of these serious clinical syndromes is critical for timely administration of appropriate therapy. In this review, the pathophysiology, clinical manifestations, and treatment of invasive GAS infections are discussed. PMID: 23809722 [PubMed - in process] (Source: The Medical ...

Antianaerobic antimicrobials: spectrum and susceptibility testing.

Authors: Brook I, Wexler HM, Goldstein EJ Abstract SUMMARY Susceptibility testing of anaerobic bacteria recovered from selected cases can influence the choice of antimicrobial therapy. The Clinical and Laboratory Standards Institute (CLSI) has standardized many laboratory procedures, including anaerobic susceptibility testing (AST), and has published documents for AST. The standardization of testing methods by the CLSI allows comparisons of resistance trends among various laboratories. Susceptibility testing should be performed on organisms recovered from sterile body sites, those that are isolated in pure culture, or those that are clinically important and have variable or unique susceptibility patterns. Organisms that should be considered for individual isolate testing include hi...

Antibiotic Sensitivity and Resistance Patterns in Pediatric Staphylococcal Scalded Skin Syndrome

Abstract Historical resistance patterns often guide empiric antibiotic choices in staphylococcal scalded skin syndrome (SSSS), but little is known about the difference in susceptibility between SSSS and other childhood staphylococcal infections. A retrospective chart review of culture‚?�confirmed cases of SSSS seen in the inpatient dermatology consultation service at the Children's Hospital of Philadelphia between 2005 and 2011 was performed. Most cases of SSSS at our institution are due to oxacillin‚?�susceptible Staphylococcus aureus, and approximately half of the cases are due to clindamycin‚?�resistant strains. Clindamycin and a penicillinase‚?�resistant penicillin are suggested as empiric treatment for SSSS until culture susceptibility data are available to guide therapy. (Source: Ped...

Treatment of Staphylococcus aureus endocarditis with high doses of trimethoprim/sulfamethoxazole and clindamycin‚??Preliminary report

Infective endocarditis (IE) is still experiencing a high mortality rate even though this rate has been reduced in successive stages thanks to more focused antibiotics and increased indications for cardiac surgery, as is being confirmed in recent studies . Recently, following early surgery the mortality rate at Aix-Marseille Universit√© (Marseille, France) fell to 10% . However, a new increase in the number of deaths in our centre appears to be related to issues of time management and organisation in surgical treatment and, second, to the increase in the number of septic shocks related to Staphylococcus aureus . In fact, the early (‚?§3 months) fatality rate went from 9% (from 2000 to 2006) to 12% (from 2007 to 2008) and to 15% (from 2009 to 2011) (P=0.075 between the first and third groups...<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>

Corticosteroids in peritonsillar abscess treatment: A Blinded placebo‚?�controlled clinical trial

ConclusionsCombined with PTA drainage and IV antibiotics, 10 mg IV DEX resulted in less pain at 24 hours when compared to PLAC, without any serious side effects. This effect is short‚?�lived, and further research is required on factors associated with PTA treatment success. Level of Evidence1b Laryngoscope, 2013 (Source: The Laryngoscope)

Cutaneous manifestations of Nocardia brasiliensis infection in Taiwan during 2002‚??2012‚??clinical studies and molecular typing of pathogen by gyrB and 16S gene sequencing

Abstract: To observe the clinicopathologic and resistance profiles of the Nocardia brasiliensis causing cutaneous nocardiosis in Taiwan, 12 N. brasiliensis isolates were prospectively collected from patients with cutaneous nocardiosis in a hospital during 2002‚??2012. Clinicopathologic data were obtained, and isolates were identified by biochemical methods and 16S rRNA sequencing. Susceptibilities to 14 antimicrobial compounds were tested. Isolates were further genotyped by sequencing of 16S rRNA, secA1, hsp65, and gyrB genes. The nodulopustular pyoderma associated with sporotrichoid spreading was the most common skin presentations caused by N. brasiliensis. All of the isolates were susceptible to amikacin, gentamicin, tobramycin, piperacillin/tazobactam, and trimethoprim/sulfamethoxazole ...

Topical 4% nicotinamide vs. 1% clindamycin in moderate inflammatory acne vulgaris

This study aimed to compare efficacy of the topical 4% nicotinamide and 1% clindamycin gels in these patients. In this randomized, double‚?�blind clinical trial, patients with moderate inflammatory facial acne vulgaris were randomly allocated to receive either topical 4% nicotinamide (n¬ =¬ 40) or 1% clindamycin gels (n¬ =¬ 40) twice daily. In each group, they were further categorized in two subgroups with oily and non‚?�oily types of facial skin. The Cook's acne grade was determined at baseline and at weeks 4 and 8 post treatment. Acne grade decreased from an average of 5.93¬ ¬~+mn~¬ 0.83 at baseline to 4.03¬ ¬~+mn~¬ 1.33 at week 4 and 2.08¬ ¬~+mn~¬ 1.59 at week 8 in nicotinamide receivers, and from an average of 5.70¬ ¬~+mn~¬ 0.94 at baseline to 3.85¬ ¬~+mn~¬ 1.66 at week 4 and 2.03¬ ¬~+mn~¬ 1.53 at week 8 in t...

High rates of reduced susceptibility in the Bacteroides fragilis group isolated from blood cultures ‚?? The first national survey in Denmark

Bacteraemia with Bacteroides fragilis group species is associated with high mortality rates if appropriate antimicrobial therapy is not administered . Increasing resistance in the B. fragilis group has been reported worldwide, especially towards clindamycin and piperacillin/tazobactam (TZP) . Lately, resistance towards the carbapenems and metronidazole has been reported, and a recent study by Toprak et al. demonstrated an alarmingly high number of isolates (27%) from a Turkish University Hospital harbouring the cfiA gene associated with carbapenem resistance . At Odense University Hospital in Denmark, 10.2% (9/88) of B. fragilis group blood culture isolates from a 3-year period (November 2007‚??November 2010) had reduced susceptibility (intermediate-susceptible or resistant) towards merope...<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>

Foreword

Clostridium difficile was first reported as the cause of antibiotic-associated colitis in 1978. Over the subsequent 3 decades, we have witnessed a dramatic increase in the incidence and severity of infections with this organism. Today, not only do surgeons encounter pseudomembranous colitis in their own postoperative patients but they are frequently called upon to intervene in patients with the most severe disease. In this issue of Current Problems in Surgery, Drs J. Daniel Stanley, John Bartlett, Benjamin Dart, and John Ashcraft have written a masterful overview on this topic entitled, ‚??Clostridium difficile Infection.‚?� They begin with a discussion of the history of this often hospital-acquired infection, including its association with clindamycin therapy and the development of more v...

Molecular epidemiology of vancomycin-resistant enterococcal bacteraemia: results from the Canadian Nosocomial Infection Surveillance Program, 1999-2009

Conclusions The increase in bacteraemia observed since 2007 in western and central Canada appears to coincide with the shift of MLST STs. All VRE isolates remained susceptible to daptomycin, linezolid, chloramphenicol and tigecycline. (Source: Journal of Antimicrobial Chemotherapy)

Effects of subinhibitory concentrations of antibiotics on virulence factor expression by community-acquired methicillin-resistant Staphylococcus aureus

Conclusions The effect of sub-MICs on virulence expression depended on the antibiotic and the virulence factor. Clindamycin and linezolid consistently suppressed the expression of different virulence factors by CA-MRSA, whereas tigecycline specifically suppressed PVL expression. Daptomycin and vancomycin seem to have no significant effects at these concentrations. (Source: Journal of Antimicrobial Chemotherapy)

Characterization of swine isolates of Clostridium difficile in Spain: a potential source of epidemic multidrug resistant strains?

We present the first report on the ribotype distribution and antimicrobial susceptibility of C. difficile in swine in Spain. A total of 144 isolates were PCR ribotyped, and their MIC values for 13 antimicrobial agents were determined using the Etest. Toxin A and B production was assessed using a commercial immunoassay and, in the case of toxin B, a specific cytotoxicity test. Our results show a high prevalence of the toxigenic 078 ribotype (94.4%) and multidrug resistance (49.3%) among the studied isolates. A minority of isolates (5.6%) belonged to a mostly non-toxinogenic ribotype. All isolates were resistant to the fluoroquinolone ciprofloxacin, but susceptible to daptomycin, linezolid, meropenem, rifampicin, teicoplanin, tigecycline, metronidazole and vancomycin. Resistance to clindamyc...

CLINDAMYCIN HYDROCHLORIDEcapsule [REMEDYREPACK INC. ]

Updated Date: Jun 3, 2013 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>

Characteristics of Group A Streptococcus Strains Circulating during Scarlet Fever Epidemic, Beijing, China, 2011.

Authors: Yang P, Peng X, Zhang D, Wu S, Liu Y, Cui S, Lu G, Duan W, Shi W, Liu S, Li J, Wang Q Abstract Scarlet fever is one of a variety of diseases caused by group A Streptococcus (GAS). During 2011, a scarlet fever epidemic characterized by peak monthly incidence rates 2.9-6.7 times higher than those in 2006-2010 occurred in Beijing, China. During the epidemic, hospital-based enhanced surveillance for scarlet fever and pharyngitis was conducted to determine characteristics of circulating GAS strains. The surveillance identified 3,359 clinical cases of scarlet fever or pharyngitis. GAS was isolated from 647 of the patients; 76.4% of the strains were type emm12, and 17.1% were emm1. Almost all isolates harbored superantigens speC and ssa. All isolates were susceptible to penicilli...

Antimicrobial susceptibility and molecular typing of MRSA in cystic fibrosis

ConclusionsIn this U.S. study, most MRSA isolates in the pediatric CF population were SCCmec II PVL negative. Rates of resistance were low, including to older and orally available antibiotics such as trimethoprim‚??sulfamethoxazole. Pediatr Pulmonol. ¬© 2013 Wiley Periodicals, Inc. (Source: Pediatric Pulmonology)

[Emergence of high-level resistance to gentamicin and streptomycin in Streptococcus agalactiae in Buenos Aires, Argentina].

Conclusions. This study highlights the emergence of strains with HLR to aminoglycosides. The disk-agar diffusion test performed with high-content aminoglycoside disks and screening plates can provide laboratories with a convenient and reliable method for detecting S. agalactiae isolates that are resistant to aminoglycoside-betalactam synergy. PMID: 23817648 [PubMed - in process] (Source: Revista Espanola de Quimioterapia)

A probable case of acquired toxoplasmosis presenting as pyrexia of unknown origin in an immunocompetent individual

We report a probable case of acquired toxoplasmosis in an immunocompetent woman who presented with fever of 6 months duration with lymphadenopathy and splenomegaly. The diagnosis was confirmed by serology and the presence of Toxoplasma gondii tachyzoites on bone marrow aspirate. The patient was successfully treated with pyrimethamine plus clindamycin. (Source: International Journal of Infectious Diseases)

CLINDAMYCIN HYDROCHLORIDEcapsule [REMEDYREPACK INC. ]

Updated Date: May 28, 2013 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>

Linezolid Desensitization for a Patient with Multiple Medication Hypersensitivity Reactions (July/August).

CONCLUSIONS:Linezolid desensitization can be a viable option in patients requiring antimicrobial therapy for complicated gram-positive skin infections. PMID: 23715068 [PubMed - as supplied by publisher] (Source: The Annals of Pharmacotherapy)

Antibiotic resistance patterns among group B Streptococcus isolates: implications for antibiotic prophylaxis for early-onset neonatal sepsis.

CONCLUSION: Rates of clindamycin and erythromycin resistance are also increasing in our context. These antibiotics should not be used for GBS neonatal sepsis prevention, without adequate antimicrobial susceptibility testing. In case of penicillin allergy and lack of antibiogramm, cephalosporins or vancomycin should be used as recommended in CDC guidelines. PMID: 23572445 [PubMed - in process] (Source: Swiss Medical Weekly)

Active screening of group B streptococci with reduced penicillin susceptibility and altered serotype distribution isolated from pregnant women in Kobe, Japan.

Authors: Kimura K, Matsubara K, Yamamoto G, Shibayama K, Arakawa Y Abstract Group B streptococcus (GBS; Streptococcus agalactiae) is a leading cause of neonatal invasive infections and was believed to be fully susceptible to penicillin. However, we recently identified several clinical GBS isolates with reduced penicillin susceptibility (PRGBS), which were mainly isolated from respiratory specimens of elderly people. An investigation of both the isolation rate of PRGBS and the serotype distribution among pregnant women is crucial to decisions regarding optimal prevention and strategies for GBS treatment in neonates. We collected 141 GBS isolates from vaginal specimens of 122 pregnant women in a hospital in Kobe, Japan, from 2007 to 2008. Of the 141 GBS isolates, 139 were subjected t...

Management of intratonsillar abscess in children

ConclusionsClinically stable children with intratonsillar abscess or phlegmon respond to trial of intravenous antibiotic therapy. Surgical drainage can accomplish clinical resolution in the presence of combination of intra‚?� and peri‚?�tonsillar abscess, airway compromise, or unresponsiveness to medical treatment. (Source: Pediatrics International)

Peritoneal dialysis peritonitis by anaerobic pathogens: a retrospective case series

Conclusion: Anaerobic PD-associated peritonitis might be predominantly caused by contamination, rather than intra-abdominal events. Half of anaerobic PD-associated peritonitis episodes had polymicrobial growth. The overall outcome of anaerobic peritonitis is fair, with a high catheter survival rate. (Source: BMC Nephrology)<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>

Antimicrobial resistance and co-selection phenomenon in Listeria spp. recovered from food and food production environments.

Authors: Kovacevic J, Sagert J, Wozniak A, Gilmour MW, Allen KJ Abstract Antimicrobial resistance (AMR), co-selection phenomenon, and the relationship between reduced susceptibility (RSC) to ciprofloxacin (CIP) and resistance to other antimicrobials in Listeria spp. (n¬ =¬ 103) recovered from food processing environments (FPE) and food were investigated. Resistance of Listeria monocytogenes and other listeriae, respectively, to cefoxitin (FOX; 98% vs. 88%), CIP (7% vs. 4%), clindamycin (CLI; 33% vs. 59%) and tetracycline (6% vs. 8%) was observed, as was RSC to CIP (67% vs. 57%) and CLI (65% vs. 41%). L.¬ monocytogenes also possessed RSC to linezolid (LZD; 6%), rifampicin (2%) and streptomycin (6%), with other listeriae displaying RSC to chloramphenicol (4%). L.¬ monocytogenes serot...

Scarce detection of mobile erm genes associated with tetQ in Bacteroides and Parabacteroides from Costa Rica.

Authors: Quesada-Gómez C, Rodríguez-Cavallini E, Rodríguez C Abstract The frequency of finding of clindamycin-resistant anaerobic bacteria in clinical samples has doubled from 2008 to 2010 in Costa Rica. To determine whether this increase is due to dissemination of erm genes aided by tetQ elements, we analyzed 100 isolates of Bacteroides or Parabacteroides from a regional hospital, a national hospital, and the community. Antimicrobial susceptibilities were recorded with a broth micro-dilution method and erm genes were detected by PCR and Southern blotting. In addition, plasmid isolation and mating experiments were performed to clarify the location and mobility of the detected erm genes. Resistance to clindamycin was by far more frequent in the regional hospital (72%) than in the...

The prevalence of antibiotic resistance genes in Bacteroides fragilis group strains isolated in different European countries.

Authors: Eitel Z, S√≥ki J, Urb√°n E, Nagy E, ESCMID Study Group on Anaerobic Infection Abstract From the 2008-2009 European Bacteroides antibiotic resistance survey, we selected 161 strains for detection of antibiotic resistance genes (cepA, cfxA, cfiA, nim, ermB, ermF, ermG, linA, mefA, msrSA, tetM, tetQ, tetX, tetX1, tet36 and bexA). To facilitate the throughput, the genes were detected by Real-Time PCR. The presence of the genes was correlated with the known MIC data of the strains for the appropriate antibiotics. For the ő≤-lactams, the cepA gene was found in 70.8% of the tested strains (all resistant to ampicillin), but its presence did not correlate with the ampicillin MIC values. The cepA gene occurred at different frequencies among Bacteroides fragilis and non-fragilis Bact...

Eradication of chronic methicillin-resistant Staphylococcus aureus infection in cystic fibrosis patients. An observational prospective cohort study of 11 patients

Conclusion: Chronic MRSA infection can be eradicated from respiratory tract samples using a six month dual antibiotic regimen and topical MRSA decolonization measures. (Source: Journal of Cystic Fibrosis)

Antimicrobial Resistance, Virulence Genes, and Genetic Lineages of Staphylococcus pseudintermedius in Healthy Dogs in Tunisia.

Authors: Gharsa H, Ben Slama K, Gómez-Sanz E, Lozano C, Klibi N, Jouini A, Messadi L, Boudabous A, Torres C Abstract Nasal swabs of 100 healthy dogs were obtained in 2011 in Tunisia and tested for Staphylococcus pseudintermedius recovery. Antimicrobial resistance profile and virulence gene content were determined. Multilocus-sequence-typing (MLST) and SmaI-pulsed-field gel electrophoresis (PFGE) were investigated. S. pseudintermedius was recovered in 55 of the 100 tested samples (55 %), and one isolate per sample was further studied. All 55 S. pseudintermedius isolates were susceptible to methicillin (MSSP) but showed resistance to the following antimicrobials (% resistant isolates/resistance gene): penicillin (56.4/blaZ), tetracycline (40/tetM), trimethoprim-sulfamethoxazole (23...<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>

Nasal carriage and antimicrobial susceptibility of Staphylococcus aureus among medical students at the HRH Princess Maha Chakri Sirindhorn Medical Center, Thailand: A cross sectional study

Conclusions: The prevalence of asymptomatic nasal carriage of S. aureus was higher than reported by previous literature in Thailand, and S. aureus isolates exhibited relatively high resistance to erythromycin and clindamycin. (Source: Journal of Infection and Public Health)

Antimicrobial resistance of Enterococcus species from meat and fermented meat products isolated by a PCR-based rapid screening method.

Authors: Jahan M, Krause DO, Holley RA Abstract Enterococci are predominantly found in the gastrointestinal tract of humans and animals, but species commonly resident on vegetation are known. Their presence in large numbers in foods may indicate a lapse in sanitation and their ability to serve as a genetic reservoir of transferable antibiotic resistance is of concern. Conventional culture methods for identification of enterococci are slow and sometimes give false results because of the biochemical diversity of the organisms in this genus. This work reports the development of a PCR-based assay to detect enterococci at the genus level by targeting a 16S rRNA sequence. Published 16S rRNA sequences were aligned and used to design genus specific primers (EntF and EntR). The primers were...

Detection of Methicillin-Susceptible Staphylococcus aureus ST398 and ST133 Strains in Gut Microbiota of Healthy Humans in Spain.

Authors: Benito D, Lozano C, G√≥mez-Sanz E, Zarazaga M, Torres C Abstract Fecal samples of 100 healthy humans were tested for Staphylococcus aureus recovery. Fifteen samples (15¬ %) contained S. aureus, all methicillin-susceptible (MSSA), being one isolate/sample further studied. These 15 isolates were characterized by spa and agr typing as well as multi-locus sequence typing. High diversity of spa types (n‚??=‚??11) and sequences types (n‚??=‚??8) was detected. Two S. aureus of lineages ST398 or ST133 were detected, and six isolates were ascribed to clonal complex 30 (CC30). Strains were susceptible to most of the 17 antimicrobial agents tested with exceptions: erythromycin/clindamycin (three strains, containing erm(C) and/or erm(A) + mph(C) genes) and tobramycin and mupirocin (on...

Changes in serotype prevalence and antimicrobial resistance among invasive Streptococcus pneumoniae isolates in Korea, 1996-2008.

Authors: Lee S, Bae S, Lee KJ, Yu JY, Kang Y Abstract We investigated changes in serotypes and antimicrobial susceptibilities among 386 isolates of invasive Streptococcus pneumoniae collected from numerous hospitals in Korea from 1996-2008. Serotype 19F (9.8%), 23F (8.3%), 19A (7.8%), 6A (7.5%), 3 (7.3%), 9V (6.5%), 6B (6.2%), 14 (4.9%), 1 (3.9%), 11A (3.9%) and 4 (3.1%) represented 69.2% of all isolates. While the overall proportion of PCV7 serotypes was stable over time, we observed modest decreases in children &lt; 5-years-of-age and adults ‚?• 65-years-of-age between 1996-1999 and 2007-2008. An increased prevalence of non-PCV7 serotypes in these age groups was primarily attributable to an increase in serotypes 3, 6A and 19A. Most invasive S. pneumoniae isolates showed high resi...

CLINDAMYCIN PALMITATE HYDROCHLORIDE (PEDIATRIC)Solution [Aurobindo Pharma Limited]

Updated Date: May 3, 2013 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>

CLEOCIN PHOSPHATE (Clindamycin Phosphate) Injection, Solution [Pharmacia And Upjohn Company]

Updated Date: May 2, 2013 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

Acute generalized exanthematous pustulosis with multiple organ dysfunction syndrome.

Authors: Mohyuddin GR, Al Asad M, Scratchko L, Khaleeq G Abstract Acute generalized exanthematous pustulosis is a rare condition characterized by sterile pustules on erythematous and edematous tissue. Mostly drug induced, this condition can also be caused by other factors. Cases due to vancomycin are rare. A 67-year-old woman with cellulitis of the left lower extremity was admitted with marked bilateral lymphedema of the lower extremities and diffuse erythema of the left lower extremity from foot to knee. She was given clindamycin and then vancomycin. On day 5, her condition worsened, with erythema involving the entire back. Although treatment with clindamycin and vancomycin was discontinued, acute generalized exanthematous pustulosis developed. After successful treatment of other ...

Healthy 51-Year-Old Male With Peritonsillar Swelling

[Ann Emerg Med. 2013;61:520.] A 51-year-old healthy man was sent to the emergency department for evaluation of a peritonsillar abscess after 3 weeks of sore throat and completion of a course of clindamycin. He had developed odynophagia to solids and observed purulent drainage from the back of his mouth. Systemic symptoms were absent, the patient's vital signs were normal, and a right-sided peritonsillar mass was observed on oropharyngeal examination (). Bedside intracavitary ultrasonography was performed (), and needle aspiration of the peritonsillar mass was attempted under ultrasonographic guidance. A small amount of yellow-pink fluid was sent for analysis. Otolaryngology was consulted and computed tomography (CT) of the neck was performed (). (Source: Annals of Emergency Medicine)

Serious Group A Streptococcal Infections

The spectrum of illnesses caused by group A streptococcus (GAS) includes invasive infections, noninvasive infections, and noninfectious complications. Increasingly virulent infections associated with high morbidity and mortality have been observed since the late 1980s and continue to be prevalent in North America and worldwide. Penicillin remains the therapy of choice, with the addition of clindamycin recommended in high risk cases. Early recognition of GAS as the cause of these serious clinical syndromes is critical for timely administration of appropriate therapy. In this review, the pathophysiology, clinical manifestations, and treatment of invasive GAS infections are discussed. (Source: Medical Clinics of North America)

Presence of Inducible Clindamycin Resistance Phenotype and erm Genes in Foodborne Staphylococcus aureus Isolates

Foodborne Pathogens and Disease , Vol. 0, No. 0. (Source: Foodborne Pathogens and Disease)<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>

Microbiology and antimicrobial treatment of pediatric cervical lymphadenitis requiring surgical intervention

Conclusions: A single antibiotic that treats S. pyogenes and S. aureus should be the empiric antibiotic for cervical lymphadenitis requiring incision and drain. We recommend sending only aerobic cultures intraoperatively as a routine practice as other pathogens are rare. (Source: International Journal of Pediatric Otorhinolaryngology)

In vitro susceptibility to antibiotics of staphylococci in biofilms isolated from orthopaedic infections

Abstract: Prosthetic joint infections (PJIs) are related to the formation of biofilms, mainly by Staphylococcus aureus and Staphylococcus epidermidis. Therapy is usually selected according conventional susceptibility testing, but these data may be insufficient to detect the true antibiotic susceptibility in the biofilm. In total, 32 clinical strains (17 S. aureus and 15 S. epidermidis) isolated from patients with PJIs as well as 2 collection strains (S. aureus 15981 and S. epidermidis ATCC 35984) were tested against nine antibiotics commonly used in the treatment of PJIs (rifampicin, vancomycin, tigecycline, clindamycin, trimethoprim/sulfamethoxazole, ciprofloxacin, cloxacillin, daptomycin and fosfomycin) using the Calgary Biofilm Device. None of the antibiotics proved to be totally effect...

CLINDESSE (Clindamycin Phosphate) Cream [Ther-Rx Corporation]

Updated Date: Apr 17, 2013 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

CLINDAMYCIN HYDROCHLORIDE ORAL DROPS (Clinamycin Hydrochloride) Liquid [FIRST PRIORITY INCORPORATED]

Updated Date: Apr 16, 2013 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

CLINDAMYCIN (Clindamycin Phosphate) Injection [Akorn, Inc.]

Updated Date: Apr 8, 2013 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>

[Rational approach of antibioprophylaxis: Systematic review in ENT cancer surgery.]

Authors: Garnier M, Blayau C, Fulgencio JP, Baujat B, Arlet G, Bonnet F, Quesnel C Abstract In head and neck cancer surgery antibiotic prophylaxis is effective in reducing the incidence of surgical site infections (SSI). However, controversies between antibiotic prophylaxis and curative antibiotic therapy exist, particularly when complex and decaying surgeries are performed in risky underlying conditions, with a risk of persisting salivary effusion in the postoperative period, or in the case of reconstruction with myo-cutaneous flaps. We have performed a systematic review of the literature according to PRISMA recommendations to answer the following questions: indications for antibiotic prophylaxis and curative antibiotic therapy, optimal duration, and choice of antibiotics for prop...

Antibiotic resistance in human peri‚?�implantitis microbiota

ConclusionsPeri‚?�implantitis patients frequently yielded submucosal bacterial pathogens resistant in vitro to individual therapeutic concentrations of clindamycin, amoxicillin, doxycycline, or metronidazole, but only rarely to both amoxicillin and metronidazole. Due to the wide variation in observed drug resistance patterns, antibiotic susceptibility testing of cultivable submucosal bacterial pathogens may aid in the selection of antimicrobial therapy for peri‚?�implantitis patients. (Source: Clinical Oral Implants Research)

In vitro activity of cadazolid against Clostridium difficile strains isolated from primary and recurrent infections in Stockholm, Sweden.

Authors: Rashid MU, Lozano HM, Weintraub A, Nord CE Abstract One hundred thirty-three Clostridium difficile strains were collected from 71 patients and analyzed for the presence of C.¬ difficile toxin B by the cell cytotoxicity neutralization assay, genes for toxin A, toxin B,¬ binary toxin and TcdC deletion by PCR. All strains were also PCR-ribotyped and analyzed for sporulation frequency. The MICs of the isolates were determined against cadazolid and seven other antimicrobial agents by the agar dilution method. All isolates were positive for toxin B by the cell cytotoxicity neutralization assay. One hundred fourteen isolates were positive for toxin A and B and 16 isolates were positive for toxin A, toxin B and binary toxin by PCR. Three isolates were negative for toxin A but posi...

Pharmacokinetics of antibacterial agents in the CSF of children and adolescents.

Authors: Sullins AK, Abdel-Rahman SM Abstract The adequate management of central nervous system (CNS) infections requires that antimicrobial agents penetrate the blood-brain barrier (BBB) and achieve concentrations in the CNS adequate for eradication of the infecting pathogen. This review details the currently available literature on the pharmacokinetics (PK) of antibacterials in the CNS of children. Clinical trials affirm that the physicochemical properties of a drug remain one of the most important factors dictating penetration of antimicrobial agents into the CNS, irrespective of the population being treated (i.e. small, lipophilic drugs with low protein binding exhibit the best translocation across the BBB). These same physicochemical characteristics determine the primary dispo...

Not What It Looks Like: A Transient Cardiomyopathy

Significant cardiac signs and symptoms developed in a young patient undergoing treatment for a severe infection. The 23-year-old man presented with a left groin abscess and a 5-day history of fever. Computed tomography (CT) showed findings consistent with fasciitis (). He was initially treated with intravenous vancomycin, ampicillin-sulbactam, and clindamycin. On hospital day 2, he developed severe chest pain, dyspnea, and nonsustained ventricular tachycardia. (Source: The American Journal of Medicine)<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>

Comparison of methicillin-resistant Staphylococcus aureus strains isolated in 2003 and 2008 with an emergence of multidrug resistant ST22: SCCmec IV clone in a tertiary hospital, Malaysia.

CONCLUSION: Vancomycin remains the most active agent in¬ vitro against S. aureus infection followed by linezolid and teicoplanin. The prevalence of resistance to fluoroquinolones, aminoglycosides (netilmicin), and tetracyclines had increased over the years. The Malaysian multidrug-resistant MRSA isolates were mostly SCCmec type III and ST239, although SCCmec type IV: ST22 is gaining importance. There was a correlation between resistotypes and PFGE profiles. PMID: 23523045 [PubMed - as supplied by publisher] (Source: Journal of Microbiology, Immunology, and Infection)

Physical compatibility of various drugs with neonatal total parenteral nutrient solution during simulated Y-site administration.

CONCLUSION: Caffeine citrate, clindamycin, enalaprilat, epinephrine, fluconazole, fosphenytoin sodium, hydrocortisone, metoclopramide, and midazolam exhibited no visual or turbidimetric evidence of incompatibility when combined with a neonatal TPN solution for up to three hours in a simulated Y-site injection. Amiodarone, pentobarbital, phenobarbital, and rifampin were not compatible with the neonatal TPN solution and should not be coadministered via Y-site injection. PMID: 23456406 [PubMed - in process] (Source: American Journal of Health-System Pharmacy : AJHP)

Prevalence, Antimicrobial Resistance, and Virulence Characteristics of mecA‚?�Encoding Coagulase‚?�Negative Staphylococci Isolated from Soft Cheese in Brazil

This study highlights the extent of the antimicrobial resistance phenomenon in neglected foodborne microorganisms and the potential public health risks that are related to the consumption of CoNS‚?�contaminated soft cheese. (Source: Journal of Food Science)

Odontogenic Abscess

A 56-year-old diabetic man presented to the Emergency Department with dysphagia, odynophagia, fever, and pronounced neck swelling for 5 days. On arrival to the Emergency Department, the patient was afebrile and protecting his airway. Physical examination revealed poor dentition without pooled secretions or elevated floor of his mouth. He had a large, indurated, submental mass just lateral to the trachea. Intravenous hydration and clindamycin were administered. Otolaryngology surgery accompanied the patient for a computed tomography scan followed by surgical exploration. Intraoperatively, a 13-cm submandibular abscess was successfully drained (). Antibiotics were continued with favorable results. (Source: The Journal of Emergency Medicine)

Antimicrobial susceptibility of Propionibacterium acnes isolates from acne patients in Colombia

Conclusions‚?? Antimicrobial resistance in P.¬ acnes in this Colombian population has a lower prevalence than those reported in Europe and follows a similar pattern to findings elsewhere in Latin America. Resistance is demonstrated even in isolates from patients with no previous history of antibiotic use. Resistance to erythromycin is most commonly observed. Minocycline emerges as the most effective antibiotic. (Source: International Journal of Dermatology)<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>

Oral clindamycin and rifampicin in the treatment of hidradenitis suppurativa‚?�acne inversa: a prospective study on 23 patients

(Source: Journal of the European Academy of Dermatology and Venereology)

Antibiotics for treating bacterial vaginosis in pregnancy.

CONCLUSIONS: Antibiotic treatment can eradicate bacterial vaginosis in pregnancy. The overall risk of PTB was not significantly reduced. This review provides little evidence that screening and treating all pregnant women with bacterial vaginosis will prevent PTB and its consequences. When screening criteria were broadened to include women with abnormal flora there was a 47% reduction in preterm birth, however this is limited to two included studies. PMID: 23440777 [PubMed - in process] (Source: Cochrane Database of Systematic Reviews)

Comparing a combination of penicillin G and gentamicin to a combination of clindamycin and amikacin as prophylactic antibiotic regimens in prevention of clean contaminated wound infections in cancer surgery.

CONCLUSION: Both penicillin+gentamicin and clindamycin+amikacin are safe and effective for the prevention of SSI in clean contaminated operative procedures. In a resource limited hospital, a regimen including penicillin+gentamicin is a cost-effective alternative for the more expensive and broader coverage of clindamycin+amikacin. Timing of PA is effective in preventing SSIs when administered 30min before the start of surgery. PMID: 23499204 [PubMed - in process] (Source: J Egypt Natl Canc In...)

Isolation, molecular characterization and antimicrobial susceptibilities of isolates of Mycoplasma agalactiae from bulk tank milk in an endemic area of Spain

ConclusionsBased on the in vitro assay clindamycin, the quinolones, tylosin and tilmicosin would be appropriate antimicrobials for contagious agalactia treatment. The isolates were mostly resistant to erythromycin, indicating that it would not be a suitable choice for therapy. The isolates showed common molecular and protein profiles by PFGE and SDS‚?�PAGE, with minor differences observed by immunoblot analysis, suggesting a clonal relationship among them. Significance and impact of studyThis study demonstrated the importance of the appropriate selection of antimicrobials for treatment of contagious agalactia.¬© 2013 The Authors Journal of Applied Microbiology ¬© 2013 The Society for Applied Microbiology (Source: Journal of Applied Microbiology)

Antimicrobial susceptibility and genetic characteristics of Propionibacterium acnes isolated from patients with acne

Conclusions‚?? Resistance to trimethoprim‚??sulfamethoxazole was the most common pattern found, and further studies are required to clarify its resistance mechanism. A certain tetracycline resistance was expected, but interestingly all strains remained sensitive. Resistance to erythromycin and clindamycin were influenced using topical formulations. Mutation A2059G was related to high resistance to erythromycin. Antibiotic resistance is increasing, and new strategies are needed. (Source: International Journal of Dermatology)<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>

Causative Pathogens, Antibiotic Sensitivity, Resistance Patterns, and Severity in¬ a Contemporary Series of Fournier's Gangrene

Conclusion: Fournier's gangrene remains a community-acquired polymicrobial infection, with anaerobic bacteria as the most common causative pathogens. Candida and methicillin-resistant S aureus are emerging causative pathogens, but methicillin-resistant S aureus remains sensitive to clindamycin and trimethoprim/sulfamethoxazole. Although resistance was demonstrated by some causative pathogens, together, the currently recommended broad-spectrum antibiotics adequately covered all pathogens. Coverage with agents such as fluconazole, vancomycin, or piperacillin-tazobactam is indicated in patients at risk of fungal or hospital-acquired organisms. (Source: Urology)

Clindamycin: Fatal DRESS syndrome: case report

(Source: Reactions)

Antimicrobial Prophylaxis and Outpatient Management of Fever and Neutropenia in Adults Treated for Malignancy: American Society of Clinical Oncology Clinical Practice Guideline [ASCO SPECIAL ARTICLES]

Purpose To provide guidelines on antimicrobial prophylaxis for adult neutropenic oncology outpatients and on selection and treatment as outpatients of those with fever and neutropenia. Methods A literature search identified relevant studies published in English. Primary outcomes included: development of fever and/or infections in afebrile neutropenic outpatients and recovery without complications and overall mortality in febrile neutropenic outpatients. Secondary outcomes included: in afebrile neutropenic outpatients, infection-related mortality; in outpatients with fever and neutropenia, defervescence without regimen change, time to defervescence, infectious complications, and recurrent fever; and in both groups, hospital admissions, duration, and adverse effects of antimicrobials. An Ex...

Bacteraemias in tropical Australia: changing trends over a 10-year period

Abstract: Bacteraemia is an important cause of morbidity and mortality worldwide. This is the largest reported study of bacteraemias in Australia. The presence of organisms endemic to the tropical region and the changing trends described have significant implications for empirical antibiotic therapy. This retrospective study examined 8976 blood cultures from Townsville Hospital, a regional Australian hospital located in the tropics over a 10-year period. The rate of bacteraemic episodes during the study period was 10.12 per 1000 admissions. Intravenous devices (18.7%), immunosuppressive therapy (16.1%), and urinary tract infections (16.1%) were important sources for bacteraemia. The most common organisms were Staphylococcus aureus (20.9%) and Escherichia. coli (15.6%). A significant reduct...

CLINDAMYCIN PHOSPHATEsolution [VersaPharm Incorporated]

Updated Date: Feb 13, 2013 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>

How Important Are Anaerobic Bacteria in Aspiration Pneumonia: When Should They Be Treated and What Is Optimal Therapy

Anaerobic bacteria are infrequent pulmonary pathogens, and, even then they are, they are almost never recovered due to the need for specimens uncontaminated by the upper airway flora and failure to do adequate anaerobic bacteriology. These bacteria are relatively common in selected types of lung infections including aspiration pneumonia, lung abscess, necrotizing pneumonia and emphyema. Preferred antibiotics for these infections based on clinical experience are clindamycin and any betalactam-betalactamase inhibitor. (Source: Infectious Diseases Clinics of North America)

CLINDAMYCIN IN 5 PERCENT DEXTROSEinjection, Solution [Sandoz Inc]

Updated Date: Feb 11, 2013 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

Experimental Evidence that Granulocyte Transfusions are Efficacious in Treatment of Neutropenic Hosts with Pulmonary Aspergillosis.

Conclusion:Our present results provide an experimental basis for enthusiasm for PMN transfusions in the therapy of aspergillosis in man. PMID: 23380731 [PubMed - as supplied by publisher] (Source: Antimicrobial Agents and Chemotherapy)

Macrolides inhibit Fusobacterium nucleatum-induced MUC5AC induction in human airway epithelial cells.

In this study, we examined whether Fn induces mucin secretion in airway epithelial cells. We also examined the effects of macrolides on the Fn-induced mucus production compared with other antibiotics that exert anti-anaerobic activities. MUC5AC production in bronchial epithelial cells after stimulation with culture supernatants (Sup) of Fn was analyzed by performing enzyme-linked immunosorbent assay and quantitative RT-PCR. The cell-signaling pathway of Fn Sup stimulation was also analyzed by performing Western blotting. For inhibition studies, cells were treated with azithromycin, clarithromycin, clindamycin (CLDM), and metronidazole (MTZ). The Fn Sup-induced NCI-H292 cells to express MUC5AC at both the protein levels and the mRNA level in both a time- and dose-dependent manner. Macrolide...

CLINDAMYCIN HYDROCHLORIDEcapsule [Mylan Pharmaceuticals Inc.]

Updated Date: Feb 1, 2013 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>

Methicillin resistant Staphylococcus aureus (MRSA) in India: prevalence & susceptibility pattern.

CONCLUSIONS: The study showed a high level of MRSA in our country. There is a need to study epidemiology of such infections. Robust antimicrobial stewardship and strengthened infection control measures are required to prevent spread and reduce emergence of resistance. PMID: 23563381 [PubMed - in process] (Source: The Indian Journal of Medical Research)

[Detection of anaerobes and drug sensitivity from the periodontal pockets of patients with combined periodontal-endodontic lesions].

CONCLUSIONS: There is a close relationship between anaerobes and combined periodontal-endodontic lesions. Drug sensitive susceptibility should be detected prior to clinical treatment of combined periodontal-endodontic lesions. Supported by Key Medical Discipline Project of Bureau of Health of Yangpu District (2009AA02-09). PMID: 23552785 [PubMed - in process] (Source: Shanghai Journal of Stomatology)

CLINDAMYCIN (Clindamycin Phosphate) Injection, Solution [Hospira, Inc.]

Updated Date: Jan 23, 2013 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

EVOCLIN (Clindamycin Phosphate) Aerosol, Foam [Stiefel Laboratories Inc]

Updated Date: Jan 9, 2013 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

High prevalence of fluoroquinolone-resistant group B streptococci among clinical isolates in China: predominance of ST19 with serotype III.

Authors: Wang H, Zhao C, He W, Zhang F, Zhang L, Cao B, Sun Z, Xu Y, Yang Q, Mei Y, Hu B, Chu Y, Liao K, Yu Y, Hu Z, Ni Y Abstract A total of 146 Group B Streptococcus isolates from 8 cities across China belonged to four serotypes. Serotype Ia was more common in children. High prevalence of resistance was observed for levofloxacin (37.7%), erythromycin (71.2%), clindamycin (54.1%), and tetracycline (81.5%). The levofloxacin and clindamycin resistances among the 4 serotypes differed significantly. Eighty percent of fluoroquinolone-resistant isolates belonged to ST19/serotype III clone with GyrA-ParC-ParE triple substitutions. This clone carried erm(B), mef(E), and tet(M) genes. PMID: 23295933 [PubMed - as supplied by publisher] (Source: Antimicrobial Agents and Chemotherapy)<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>

CLINDAMYCIN HYDROCHLORIDEcapsule [PD-Rx Pharmaceuticals, Inc.]

Updated Date: Jan 2, 2013 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

Fluoroquinolones and Ocular MRSA Infections

We read with great interest and appreciation the paper ‚??Methicillin-Resistant Staphylococcus aureus Ocular Infection: A 10-Year Hospital-Based Study‚?� by Hsiao et al. In their study, Staphylococcus aureus was isolated from 519 patients with ocular infections, 274 (52.8%) of which had methicillin-resistant S aureus (MRSA) infections. No difference in gender distribution was identified (male:female = 138:136) in these MRSA patients. Both community-associated (CA) and healthcare-associated (HA) MRSA isolates were resistant to clindamycin and erythromycin, but CA-MRSA was more susceptible to sulfamethoxazole/trimethoprim. Unfortunately, the study lacks information on the in vitro susceptibility of ocular MRSA infections to fluoroquinolones. (Source: Ophthalmology)

Perrigo Company Acquires Remaining Stake In Cobrek Pharmaceuticals, Inc. For Approximately $45 Million

-- Solidifies Perrigo's leadership position in topical foam-based generic prescription pharmaceuticals -- Concludes 4+ year collaborative partnership responsible for successful launches of generic versions of Evoclin&#174; (clindamycin phosphate)... (Source: Drugs.com - Pharma News)

Perrigo Company Acquires Remaining Stake in Cobrek Pharmaceuticals, Inc. for Approximately $45 Million

Solidifies Perrigo's leadership position in topical foam-based generic prescription pharmaceuticals Concludes 4+ year collaborative partnership responsible for successful launches of generic versions of Evoclin&reg; (clindamycin phosphate) Foam 1% and E... Biopharmaceuticals, Generics, Mergers & AcquisitionsPerrigo Company, Cobrek Pharmaceuticals (Source: HSMN NewsFeed)

In vitro antibiotic susceptibility patterns of Propionibacterium acnes isolated from acne patients: an Egyptian university hospital‚?�based study

Conclusion‚?? Propionibacterium acnes in vitro susceptibility patterns differed among Egyptian patients to the commonly prescribed antibiotics with the highest to lowest resistance to clindamycin, erythromycin, oxytetracycline, doxycycline and azithromycin. (Source: Journal of the European Academy of Dermatology and Venereology)<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>

CLINDAMYCIN - BENZOYL PEROXIDE (Clindamycin Phosphate And Benzoyl Peroxide) Gel [Prasco Laboratories]

Updated Date: Dec 13, 2012 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

DUAC (Clindamycin Phosphate And Benzoyl Peroxide) Gel [Stiefel Laboratories Inc]

Updated Date: Dec 12, 2012 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

Clindamycin: Neutropenia: case report

(Source: Reactions)

In Vivo Bioluminescence Imaging to Evaluate Systemic and Topical Antibiotics against Community-Acquired Methicillin-Resistant Staphylococcus aureus-Infected Skin Wounds in Mice.

Authors: Guo Y, Ramos RI, Cho JS, Donegan NP, Cheung AL, Miller LS Abstract Community-acquired methicillin-resistant Staphylococcus aureus (CA-MRSA) frequently causes skin and soft-tissue infections, including impetigo, cellulitis, folliculitis, and infected wounds and ulcers. Uncomplicated CA-MRSA skin infections are typically managed in an outpatient setting with oral and topical antibiotics and/or incision and drainage whereas complicated skin infections often require hospitalization, intravenous antibiotics, and sometimes surgery. The aim of this study was to develop a mouse model of CA-MRSA wound infection to compare the efficacy of commonly used systemic and topical antibiotics. A bioluminescent USA300 CA-MRSA strain was inoculated into full-thickness scalpel wounds on the ba...

Group A Streptococcus Toxic Shock Syndrome: An outbreak report and review of the literature

Highlights: ‚?ļ Invasive GAS TSS is a serious disease with a high case fatality rate; an ongoing health challenge. ‚?ļ Early implementation of infection control measures is very crucial in the successful management and control of this outbreak. ‚?ļ Infection control investigations should start after the identification of the first case. ‚?ļ Mode of GAS transmission needs further studies. ‚?ļ The first report on GAS Toxic Shock Syndrome in Qatar.Summary: Group A Streptococcal (GAS) Toxic Shock Syndrome (TSS) is an acute, rapidly progressive, and often fatal illness. Outbreaks can occur in hospitals. However, early infection control measures may interrupt transmissions and prevent morbidity and mortality.Two cases of invasive GAS TSS were diagnosed within 48h after two uncomplicated laparosc...<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>

Pharmacotherapy for Methicillin-Resistant Staphylococcus aureus Nosocomial Pneumonia.

CONCLUSIONS: Based on the currently available evidence and cost-effectiveness, vancomycin should continue to be the drug of choice for most patients with nosocomial MRSA pneumonia. Linezolid is a reasonable alternative for patients with treatment failure while receiving vancomycin, isolates with vancomycin minimum inhibitory concentrations over 2 őľg/mL, allergic reactions, or vancomycin-induced nephrotoxicity. PMID: 23232021 [PubMed - in process] (Source: The Annals of Pharmacotherapy)

Resistance of Bacteroides isolates recovered among clinical samples from a major Costa Rican hospital between 2000 and 2008 to √?-lactams, clindamycin, metronidazole, and chloramphenicol.

Conclusions. The high MIC for clindamycin obtained for the majority of the resistant strains is highly suggestive of the presence of mechanisms of acquired resistance among the isolates, therefore surveillance studies are required to determine its efficacy. The low resistance to metronidazole observed underlines its value as a first-line drug. On the other hand, imipenem could be used to treat infections that do not respond well to metronidazole or clindamycin. PMID: 23303257 [PubMed - in process] (Source: Revista Espanola de Quimioterapia)

The effect of calcium hydroxide on the antibiotic component of Odontopaste¬ģ and Ledermix¬ģ paste

ConclusionThe addition of calcium hydroxide to Odontopaste¬ģ or Ledermix¬ģ Paste results in reductions of the respective antibiotic over a 7‚?�day time period. (Source: International Endodontic Journal)

The tolerability profile of clindamycin 1%/benzoyl peroxide 5% gel vs. adapalene 0.1%/benzoyl peroxide 2.5% gel for facial acne: results of a randomized, single‚?�blind, split‚?�face study

ConclusionsClindamycin/BPO had a better tolerability profile than adapalene/BPO during 2¬ weeks of split‚?�face treatment. Treatment satisfaction was highest with clindamycin/BPO. (Source: Journal of Cosmetic Dermatology)

CLINDAMYCIN HYDROCHLORIDEcapsule [Watson Laboratories, Inc.]

Updated Date: Nov 14, 2012 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>

Population pharmacokinetics of clindamycin orally and intravenously administered in patients with osteomyelitis

CONCLUSIONS The current recommendation of 600‚??mg three times daily seems to be effective up to 75‚??kg but the dose should be raised to 900‚??mg three times daily thereafter. These assumptions should be prospectively confirmed. (Source: British Journal of Clinical Pharmacology)

Antimicrobial susceptibility and resistance mechanisms of clinical Clostridium difficile from a Chinese tertiary hospital

Abstract: Clostridium difficile is a predominant cause of antibiotic-associated diarrhoea. It is increasingly difficult to treat C. difficile infection efficiently owing to its multidrug resistance. In the present study, 60 clinical C. difficile isolates were collected and analysed for their genotype, antimicrobial susceptibility and resistance mechanisms. Tandem repeat sequence typing (TRST) generated 21 types, including the epidemic clone tr017. Antimicrobial susceptibility testing of eight antibiotics was performed by the agar dilution method. Rifampicin, metronidazole and vancomycin remained the most potent agents in vitro, whilst the resistance rates of other agents such as ciprofloxacin, cefoxitin, clindamycin, tetracycline and moxifloxacin varied from 30% to 100%. 73.33% of the stra...

Nationwide surveillance of antimicrobial susceptibility patterns of pathogens isolated from surgical site infections (SSI) in Japan

Abstract&nbsp;&nbsp;To investigate the trends of antimicrobial resistance in pathogens isolated from surgical site infections (SSI), a Japanese surveillance committee conducted the first nationwide survey. Seven main organisms were collected from SSI at 27 medical centers in 2010 and were shipped to a central laboratory for antimicrobial susceptibility testing. A total of 702 isolates from 586 patients with SSI were included. Staphylococcus aureus (20.4&nbsp;%) and Enterococcus faecalis (19.5&nbsp;%) were the most common isolates, followed by Pseudomonas aeruginosa (15.4&nbsp;%) and Bacteroides fragilis group (15.4&nbsp;%). Methicillin-resistant S. aureus among S. aureus was 72.0&nbsp;%. Vancomycin MIC 2&nbsp;őľg/ml strains accounted for 9.7&nbsp;%. In Escherichia coli, 11 of 95 strains...

The newly described mecA homologue, mecALGA251, is present in methicillin-resistant Staphylococcus aureus isolates from a diverse range of host species

Conclusions The discovery of MRSA isolates possessing mecALGA251 from a diverse range of host species, including different taxonomic classes, has important implications for the diagnosis of MRSA in these species and our understanding of the epidemiology of this novel mecA homologue. (Source: Journal of Antimicrobial Chemotherapy)

Oritavancin does not induce Clostridium difficile germination and toxin production in hamsters or a human gut model

Conclusions Oritavancin exposure, unlike exposure to vancomycin or clindamycin, did not lead to CDI in hamsters. In both models, oritavancin reduced C. difficile total counts and spores to below detectable limits. The data indicate the potential of oritavancin for CDI treatment, since exposure did not induce C. difficile germination and toxin production, which are known to exacerbate the disease state. (Source: Journal of Antimicrobial Chemotherapy)<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>

An evaluation of the impact of antibiotic stewardship on reducing the use of high-risk antibiotics and its effect on the incidence of Clostridium difficile infection in hospital settings

Conclusions The restriction of the high-risk antibiotics contributed to both a reduction in their use and a reduction in the incidence of CDI in the study site hospital. Time-series analysis can be utilized as a risk classification tool with utility in antibiotic stewardship design and quality improvement programmes. (Source: Journal of Antimicrobial Chemotherapy)

[Management of post-partum infections.]

Authors: Lamy C, Zuily S, Perdriolle E, Gauchotte E, Villeroy-de-Galhau S, Delaporte MO, Wahl D, Morel O, Judlin P Abstract Post-partum endometritis are frequent and account for the fifth cause of maternal death. This disease is preventable and effective treatments are available. Streptococcus agalactiae is the primary pathogen implicated. The clinical diagnosis is usually easy and involves pelvic pain, fever and abnormal lochia. Whenever antibiotic treatment provides no clinical improvement, or in case of doubt on the vacuity of the uterus, an ultrasound exam must be performed. Likewise, a CT scan or a MRI will be performed in case of persistent fever in search of a pelvic abscess requiring a drainage, or of a pelvic thrombophlebitis. Thromboplebitis requires heparin for the durat...

Methicillin‚?�resistant Staphylococcus aureus keratitis in a dog

Abstract The purpose of this study is to report a case of methicillin‚?�resistant Staphylococcus aureus (MRSA) keratitis in a dog. A 7‚?�year‚?�old intact male American cocker spaniel that had undergone removal of a nictitating gland was referred for severe ulcerative keratitis. Slit‚?�lamp examination showed swelling of the eyelid, mucopurulent discharge, conjunctival injection and chemosis, diffuse corneal edema and opacity, and a deep ulcer in central cornea. Gram staining of discharge from the eye demonstrated Gram‚?�positive cocci. Despite topical ofloxacin, oxytetracycline and polymyxin B ophthalmic solution and intravenous cefazolin, there was no improvement. Cultures revealed MRSA that was sensitive only to chloramphenicol, vancomycin, lincomycin, and clindamycin. The antibiotic re...

Phenotypic and molecular characterization of Staphylococcus aureus recovered from different clinical specimens of inpatients at a teaching hospital in Shanghai between 2005 and 2010.

This study aimed to investigate the molecular profile, including its dynamic changes and genotype-phenotype correlation of S. aureus isolates recovered from different clinical specimens of inpatients with S .aureus infection over a six-year span at a teaching hospital in Shanghai, China. Between 2005 and 2010, random sample of 610 unique S. aureus isolates were collected from different clinical samples of inpatients with S. aureus infection for molecular and antibiotic susceptibility analysis. Our results showed that among the 610 S. aureus isolates, 20 MLST sequence types (STs; primarily ST239, ST5, ST7, ST188, and ST398) and 52 spa types (primarily t002, t037, t030, and t601) were found. In total, 444 isolates (72.8%) were MRSA and 166 (27.2%) were MSSA. The ST239-MRSA-III-spa t037 and S...

Soft Tissue Infection Caused by Burkholderia cepacia in a Child with Polyarteritis Nodosa.

Authors: Yń~+mn~ldń~+mn~z B, Duyu M, S√∂zeri B, Karapń~+mn~nar B Abstract Burkholderia cepacia belongs to a family of Burkholderia species previously described as Pseudomonas cepacia, especially in patients suffering from cystic fibrosis. There are also many studies about this agent in the last decade due to their life-threatening infections and ability to invade mucosal and cellular surfaces. Here, we report a case of soft tissue infection caused by B. cepacia in a child with an underlying condition of polyarteritis nodosa. Her complaints started at two months of age and she was on cyclosporine therapy. She was treated several times because of soft tissue infections especially in her extremities. The most common causative agents were Pseudomonas spp. and Escherichia coli, but recently, anothe...<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>

Clindamycin: Wrist monoarthritis in an elderly patient: case report

(Source: Reactions)

CLINDAMYCIN PALMITATE HYDROCHLORIDE (PEDIATRIC) (Clindamycin Palmitate Hydrochloride) Granule, For Solution [Rising Pharmaceuticals, Inc.]

Updated Date: Oct 31, 2012 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

CLEOCIN PHOSPHATE (Clindamycin Phosphate) Injection, Solution [General Injectables Vaccines, Inc]

Updated Date: Oct 31, 2012 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

High diversity of genetic lineages and virulence genes in nasal Staphylococcus aureus isolates from donkeys destined to food consumption in Tunisia with predominance of the ruminant associated CC133 lineage

Conclusions: The nares of donkeys frequently harbor MSSA. They could be reservoirs of the ruminant-associated CC133 lineage and of toxin genes encoding TSST-1 and other virulence traits with potential implications in public health. CC133 seems to have a broader host distribution than expected. (Source: BMC Veterinary Research - Latest articles)

Addressing Antimicrobial Resistance to Treat Children With Atopic Dermatitis in a Tertiary Pediatric Allergy Clinic

Conclusions. Susceptibility profiles of S aureus isolates from AD patients vary significantly from that of the general population. (Source: Clinical Pediatrics)<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>

CLINDAMYCIN HYDROCHLORIDEcapsule [PD-Rx Pharmaceuticals, Inc.]

Updated Date: Oct 23, 2012 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

10-year-old Female With a Subglottic Mass

[Ann Emerg Med. 2012;60:668.] A 10-year-old girl presented to the emergency department (ED) with a growing neck mass for the past several weeks. The mother stated that the patient had a sublingual mass around 15 days before being treated in the ED. The mother took her child to the nearest ED, where she was discharged with amoxicillin. The mass kept growing and was expanding under the left side of her jaw (). She was taken to a hospital in San Antonio, where she received intravenous clindamycin and was observed for 7 days. During this admission, radiographs were taken but the mother was unsure of the result. The patient was discharged receiving clindamycin and a steroid taper. After discharge, the mass kept expanding, so the mother decided to bring the patient to the ED. The child had not ...

Characterization of methicillin-resistant Staphylococcus aureus from skin and soft tissue infections in patients in Nairobi, Kenya

Conclusions: These findings suggest that SCCmec II MRSA and a PVL strain of MRSA are significant pathogens in patients with SSTIs presenting to hospitals in Kenya, and that MRSA cases are prevalent at publicly funded health care facilities. (Source: International Journal of Infectious Diseases)

Clindamycin: Ageusia, xerostomia and burning mouth syndrome: case report

(Source: Reactions)

Evolution of Helicobacter pylori susceptibility to antibiotics during a 10‚?�year period in Lithuania

The study evaluated the changes in the prevalence of Helicobacter pylori strains with primary resistance to antibiotics during the last 10¬ years in Lithuania. H. pylori susceptibilities to antibiotics were tested in 89 patients in 1998, in 81 patients in 2001 and in 90 patients in 2007/2008. Susceptibility to metronidazole, clarithromycin, amoxicillin and tetracycline was tested using E‚?�test or agar dilution method. Susceptibility to ciprofloxacin was only tested in 2007/2008. Data about utilization of all authorized and available on market macrolides and clindamycin in Lithuania during 2003‚??2007 were evaluated using WHO ATC/DDD methodology. A total of 260 H. pylori strains cultured from untreated adult patients were investigated. Primary resistance rates (1998, 2001 and 2007/2008) fo...<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>

CLINDAMYCIN PHOSPHATE AND BENZOYL PEROXIDEkit [Mylan Pharmaceuticals Inc.]

Updated Date: Oct 18, 2012 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

Comment: Probable Clindamycin-Induced Ageusia, Xerostomia, and Burning Mouth Syndrome (November).

Authors: Fortuna G, Pollio A PMID: 23073308 [PubMed - as supplied by publisher] (Source: The Annals of Pharmacotherapy)

Clindamycin: Hyperphosphataemia (first report) in a child: case report

(Source: Reactions)

CLEOCIN HYDROCHLORIDE (Clindamycin Hydrochloride) Capsule [Pharmacia And Upjohn Company]

Updated Date: Oct 10, 2012 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

CLINDAMYCIN PALMITATE HYDROCHLORIDE (PEDIATRIC) (Clindamycin Palmitate Hydrochloride) Granule, For Solution [Lyne Laboratories, Inc.]

Updated Date: Oct 2, 2012 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>

Antibiotic Exposure and IBD Development Among Children: A Population-Based Cohort Study

CONCLUSIONS: Childhood antianaerobic antibiotic exposure is associated with IBD development. (Source: PEDIATRICS)

[Probiotics for the Prevention of Antibiotic-induced Diarrhea].

Authors: Eser A, Thalhammer F, Burghuber F, H√∂genauer C, Stockenhuber F, Wenisch C, Widhalm K, Reinisch W Abstract Between 5 and 49‚??% of patients treated with antibiotics suffer from diarrhoea. Principally all microbial agents can cause diarrhoea, especially oral agents like cephalosporines, clindamycin, broad-spectrum penicillins, and quinolones of the 3‚??rd and 4th generation. Manifestations of antibiotic-associated diarrhoea range from mild self-limiting forms to severe life-threatening courses. The potentially most severe form of antibiotic-associated diarrhoea is caused by Clostridium diffcile accounting for approx. 25‚??% of antibiotic-associated diarrhoea. In the past two decades a broad spectrum of different probiotic strains has been evaluated for the primary preventio...

A comparative study of amoxicillin, clindamycin and chlorhexidine in the prevention of post-extraction bacteraemia.

Authors: Maharaj B, Coovadia Y, Vayej AC Abstract We evaluated some of the regimens recommended for the antimicrobial prophylaxis of infective endocarditis prior to dental extraction in 160 patients. Group A patients served as the control group, group B subjects rinsed their mouths with chlorhexidene, group C subjects took 3 g amoxicillin orally and group D patients took 600 mg clindamycin orally. The proportion of patients who had post-extraction bacteraemia in groups A, B, C and D was 35, 40, 7.5 and 20%, respectively. The differences between the control and amoxicillin groups (p = 0.003) and between the chlorhexidine and amoxicillin groups (p = 0.0006) were statistically significant. Streptococci were not isolated in any patients in the amoxicillin and clindamycin groups. In our...

Antimicrobial susceptibility and molecular subtypes of Staphylococcus aureus isolated from pig tonsils and cow's milk in China.

This study investigated and compared the antimicrobial resistance patterns and ribotypes of Staphylococcus aureus isolated from pig tonsils and cow's milk in China. A total of 90 isolates of S. aureus was included: 42 strains were isolated from tonsils of pigs and 48 from half-udder milk. The broth microdilution method and the double-disc diffusion test (D test) were used for antimicrobial susceptibility testing. The mecA gene for methicillin-resistant S. aureus (MRSA) and the ermA, ermB, ermC, and msrA genes for erythromycin-resistant strains were detected by polymerase chain reaction (PCR). The isolates were ribotyped with the Riboprinter system. The highest frequency of resistance was observed with clindamycin (91.1%), followed by penicillin (90.0%), and erythromycin (85.6%). All strain...

Intravitreal clindamycin plus dexamethasone versus classic oral therapy in toxoplasmic retinochoroiditis: a prospective randomized clinical trial

In conclusion, both IVCD and COT are equally effective against active toxoplasmic retinochoroiditis but the former is apparently safer and more convenient. Content Type Journal ArticleCategory Original PaperPages 1-8DOI 10.1007/s10792-012-9634-1Authors Nader Baharivand, Nikookari Eye Hospital, Tabriz University of Medical Sciences, Tabriz, IranAli Mahdavifard, Nikookari Eye Hospital, Tabriz University of Medical Sciences, Tabriz, IranRohollah Fadaei Fouladi, Medical Faculty, Tabriz University of Medical Sciences, Golgasht, Tabriz, Iran Journal International OphthalmologyOnline ISSN 1573-2630Print ISSN 0165-5701 (Source: International Ophthalmology)<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>

Genetic characterization of Panton-Valentine leukocidin-producing methicillin-resistant Staphylococcus aureus in Western Austria.

CONCLUSIONS: The major lukS-lukF-positive MRSA lineage found in our population was ST8, t008 and positive for arcA which is mainly found in the USA. In contrast, ST80 strains were not found as frequently in our region as in many other European countries. PMID: 23053569 [PubMed - as supplied by publisher] (Source: Wiener Klinische Wochenschrift)

Morphological, biochemical, physiological and molecular aspects of the response of Fusobacterium nucleatum exposed to subinhibitory concentrations of antimicrobials.

Authors: de Souza Filho JA, Diniz CG, Barbosa NB, de Freitas MC, Lopes Neves MS, da Gama Mazzei RN, Coelho CM, da Silva VL Abstract Subinhibitory concentrations (SICs) of antimicrobials may result in alterations in bacterial biology with implications for its potential aggression. This has considerable importance for the resident microbiota. Our aim was to analyze the effects of SICs of antimicrobials on the morphological, biochemical, physiological and molecular characteristics of the resident anaerobic Fusobacterium nucleatum. Fourteen strains were obtained from F.¬ nucleatum ATCC 25586, selected by culturing on SICs of ampicillin, ampicillin/sulbactam, clindamycin, chloramphenicol, levofloxacin, metronidazole and piperacillin/tazobactam and subsequent culturing in the absence of ...

CLINDAMYCIN HYDROCHLORIDEcapsule [Mylan Institutional Inc.]

Updated Date: Sep 26, 2012 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

Diversity in the antimicrobial susceptibility patterns of methicillin-resistant Staphylococcus aureus clones

Abstract&nbsp;&nbsp;Methicillin-resistant Staphylococcus aureus (MRSA) is well known for its epidemicity, with the emergence of new clones on a daily basis. Diversity in the clonal types of MRSA challenges the success of treatment, as different clones respond to different sets of antibiotics. However, the antibiotic susceptibility among the isolates within the same clones is largely unexplored. In a previous study on MRSA epidemiology in Malaysia, we identified six major clonal complexes (ST-239-CC8, ST-1-CC1, ST-188-CC1, ST-22-CC22, ST-7-CC7 and ST-1283-CC8). In the present study, we investigated the antibiotic susceptibility patterns of isolates of different clones. Three hundred and eighty-nine MRSA isolates were subjected to the disc diffusion test, oxacillin minimum inhibitory co...

Emergence of Multiresistant Methicillin‚?�Resistant Staphylococcus aureus in Two Patients with Atopic Dermatitis Requiring Linezolid Treatment

We report two patients with atopic dermatitis who developed methicillin‚?�resistant Staphylococcus aureus (MRSA) skin infections resistant to clindamycin and trimethoprim‚?�sulfamethoxazole requiring repeated linezolid treatment. For one patient and family members who received an aggressive regimen of staphylococcal decolonization, including intranasal mupirocin, dilute bleach baths, and bleach cleansing of household items and surfaces, subsequent culture results demonstrated methicillin‚?�susceptible S. aureus colonization and infection. These findings underscore the challenges presented by multiresistant MRSA infections in children with atopic dermatitis. (Source: Pediatric Dermatology)<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>

Antibacterial therapeutics for the treatment of chytrid infection in amphibians: Columbus's egg?

Conclusions: We thus conclude that, despite marked anti B. dendrobatidis activity in vitro, the florfenicol treatment used is not capable of eliminating B. dendrobatidis infections from amphibians. (Source: BMC Veterinary Research - Latest articles)

Increased Incidence of Skin and Soft Tissue Infections and Associated Antimicrobial Use: A Population-Based Study.

Conclusion: Health care utilization and antibiotic prescribing rates for SSTI, but not I&D procedures, have increased in association with the CA-MRSA epidemic. While much of the increase in antibiotic use reflects an appropriate change to trimethoprim-sulfamethoxazole, there is room for education around the limitations of cephalosporins and clindamycin, given current susceptibility profiles. PMID: 23006762 [PubMed - as supplied by publisher] (Source: Antimicrobial Agents and Chemotherapy)

Effectiveness of a short (4 day) course of oritavancin in the treatment of simulated Clostridium difficile infection using a human gut model

Conclusions Shortened courses of oritavancin and vancomycin effectively treated CDI in a human gut model, but evidence of recurrence was observed following vancomycin instillation. Oritavancin exposure inhibited the recovery of C. difficile spores, as previously described. Shortened antibiotic exposure minimizes disruption to the gut microflora. These data indicate the possible value of a 4 day oritavancin dosing regimen for CDI treatment. (Source: Journal of Antimicrobial Chemotherapy)

Molecular epidemiology of methicillin-resistant Staphylococcus aureus in a Spanish hospital over a 4-year period: clonal replacement, decreased antimicrobial resistance, and identification of community-acquired and livestock-associated clones

This study was carried out on 189 methicillin-resistant Staphylococcus aureus (MRSA) clinical isolates collected in a third-level hospital in Valladolid, Spain, between 2005 and 2008 in order to investigate the changes in molecular epidemiology and genetic backgrounds associated with the changes in resistance phenotypes produced over time. The MRSA isolates were classified as belonging to 10 different clones, including the identification of a novel MRSA clone, ST2422-MRSA-IV, belonging to CC121; 1 CA-MRSA strain from a USA300 clone; another from ST97-MRSA-IV, associated with clones adapted to livestock (LA-MRSA); and 2 strains belonging to a new spa type (t10258) related to the ST8-MRSA-IV clone. Sixty-two percent of the strains belonging to Spanish-prevalent MRSA sequence type ST125 harbo...

Preoperative Antibiotic Prophylaxis in the Penicillin-Allergic Patient

Because of their efficacy against these gram-positive cocci, cephalosporin antibiotics are commonly used as first-line prophylaxis against surgical site infection (SSI). Although this antibiotic class is largely effective, some thought must be given to situations in which cephalosporins cannot be used. Furthermore, picking an alternative to cephalosporins becomes relevant clinically because of a substantial cost difference between 2 commonly available choices. This review attempts to highlight the issues involved in the decision-making process between 2 commonly used antistaphylococcal agents: intravenous clindamycin and intravenous vancomycin. (Source: The Journal of Hand Surgery)<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>

Updated national IV monograph on Clindamycin

Source: Medusa Area: News An updated&#160;IV&#160;monograph on Clindamycin is now available from the NHS injectable medicines guide website (Medusa). Please see the link below for access (registration required). &#160; (Source: NeLM - News)

Changing microbiology of pediatric neck abscesses in iowa 2000‚??2010

Conclusions:These findings demonstrate a statistically significant rise in the proportion of MRSA neck infections in pediatric patients in Iowa. Resistance to clindamycin was highest among MSSA isolates. Clindamycin‚?�resistant S. aureus and Streptococcus pyogenes are established pathogens in neck infections. In communities with similar microbiology patterns, empiric treatment with combination therapy of a beta lactam and vancomycin or trimethoprim/sulfamethoxazole should be initiated until culture results are available. (Source: The Laryngoscope)

Clindamycin-induced neutropenia following major head and neck surgery.

Authors: Schmidt RS, Reiter ER Abstract A 64-year-old man undergoing major head and neck surgery received clindamycin for perioperative antimicrobial prophylaxis. On the third postoperative day, he became acutely neutropenic. The neutropenia resolved 3 days later, after the administration of filgrastim. After ruling out other causes of acute neutropenia, we determined that the neutropenia was secondary to clindamycin toxicity. While clindamycin-induced neutropenia has been reported elsewhere, to our knowledge this is the first report of its occurrence following head and neck surgery. Otolaryngologists should be aware of this potentially serious reaction. PMID: 22996716 [PubMed - in process] (Source: Ear, Nose and Throat Journal)

Antimicrobial susceptibility, characterization of bacitracin operon and bacitracin biosynthesis of Bacillus spp. strains isolated from primary starters for African traditional bread production.

Authors: Adimpong DB, S√łrensen KI, Thorsen L, Stuer-Lauridsen B, Abdelgadir WS, Nielsen DS, Derkx PM, Jespersen L Abstract Bacillus spp. are widely used feed additives and probiotics. However, there is limited information on their resistance towards various antibiotics, and a growing concern of transfer of antibiotic-resistance genes. The minimum inhibitory concentration (MIC) for 8 antibiotics was determined for 85 Bacillus spp. strains; Bacillus subtilis subsp. subtilis (n=29), Bacillus licheniformis (n=38) and Bacillus sonorensis (n=18), all isolated from starters for Sudanese bread production. All the strains were sensitive to tetracycline (8.0 mg/L), vancomycin (4.0 mg/L) and gentamicin (4.0 mg/L) but resistant to streptomycin. Sensitivity to clindamycin, chloramphenicol and ...

Med Sci Monit 2012; 18(9):BR356-361 &quot;Bacterial superinfection in Zoonotic Cutaneous Leishmaniasis&quot;

Conclusions: Bacterial superinfection appears to be very common in ZCL, but its prevalence is not different from that of non-ZCL lesions and it has little effect on the clinical appearance of anthroponotic cutaneous Leishmaniasis (ACL). Local lesion care and management of bacterial superinfection must be considered in the treatment of ZCL. (Source: Medical Science Monitor)<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>

Antibiogram testing of pediatric skin infections in the era of methicillin‚?�resistant Staphylococci aureus: an Egyptian University Hospital‚?�based study

Conclusions‚?? CA‚?�MRSA skin infections are not common among Egyptian children and, therefore, beta‚?�lactams are still effective empiric antimicrobial therapy for most infections. Antibiogram testing from suppurative skin lesions are, however, better to be recommended to guide individual therapy. Clindamycin should not be considered for susceptible isolates unless they are erythromycin susceptible or D‚?�test negative. (Source: International Journal of Dermatology)

Rescreening for abnormal vaginal flora in pregnancy and re-treating with clindamycin vaginal cream significantly increases cure and improvement rates

We investigated 199 pregnant women with bacterial vaginosis (BV) who received clindamycin vaginal cream (CVC) for three days and compared with 205 women treated with placebo. The vaginal flora was assessed at each visit. At the second visit, 71% in the CVC group were cured/improved, compared with 12% in the placebo group (P &lt; 0.001). At visit 3 about 90% who responded to initial CVC treatment were still cured/improved. Of women who initially failed to respond to CVC and were given an additional seven-day course, 33% were cured/improved by the third visit, compared with 15% who failed to respond to placebo initially and were given a further seven-day course (P = 0.02). By visit 4, half the women in the CVC group who received additional treatment remained cured/improved, compared with 26%...

CLINDAMYCIN PHOSPHATEgel [Lake Erie Medical DBA Quality Care Products LLC]

Updated Date: Aug 27, 2012 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

CLINDAMYCIN PHOSPHATE AND BENZOYL PEROXIDE (Clindamycin, Benzoyl Peroxide) Gel [Perrigo New York Inc]

Updated Date: Aug 27, 2012 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

Ante-Mortem Diagnosis, Diarrhea, Oocyst Shedding, Treatment, Isolation and Genetic Typing of Toxoplasma gondii Associated with Clinical Toxoplasmosis in a Naturally Infected Cat.

Authors: Dubey JP, Prowell M Abstract Abstract Toxoplasma gondii infections are common in humans and other animals but clinical disease is relatively rare. It is unknown whether the severity of toxoplasmosis in immunocompetent hosts is due to the parasite strain, host variability, or to other factors. Recently, attention has been focused on the genetic variability among T. gondii isolates from apparently healthy and sick hosts. Whether T. gondii genetic makeup plays a part in the pathogenesis of clinical feline toxoplasmosis is uncertain because little is known of genetic typing of strains associated with clinical feline toxoplasmosis. A 6- mo-old domestic male cat was hospitalized with because of lethargy, anorexia, fever, and diarrhea. Numerous (6 million in 1 sample) T. gondii ...<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>

Severe sepsis and septic shock in pregnancy.

Authors: Barton JR, Sibai BM Abstract Pregnancies complicated by severe sepsis and septic shock are associated with increased rates of preterm labor, fetal infection, and preterm delivery. Sepsis onset in pregnancy can be insidious, and patients may appear deceptively well before rapidly deteriorating with the development of septic shock, multiple organ dysfunction syndrome, or death. The outcome and survivability in severe sepsis and septic shock in pregnancy are improved with early detection, prompt recognition of the source of infection, and targeted therapy. This improvement can be achieved by formulating a stepwise approach that consists of early provision of time-sensitive interventions such as: aggressive hydration (20 mL/kg of normal saline over the first hour), initiation ...

[Systemic and local antibiotic therapy of conservative and operative treatment of spondylodiscitis.]

Authors: Fleege C, Wichelhaus TA, Rauschmann M Abstract An evidence-based recommendation for a standardized antibiotic therapy of spondylodiscitis has not yet been published. Crucial for conservative therapy is the verification of the causative organism and an appropriate antibiotic therapy. Intravenous antibiotic therapy should be administered for 2-3 weeks and a switched to oral administration for 6-12 weeks is then possible. If an empirical antimicrobial therapy is required a combination of ciprofloxacin and clindamycin, alternatively a combination of cefotaxim and flucloxacillin is recommended. Surgical removal of the infection by extensive debridement with stabilization and filling the resulting bone defect is desirable. Under the perception of a high local dose of antibiotic ...

Risk factors for development of Clostridium difficile infection due to BI/NAP1/027 strain: a meta-analysis

Conclusions: Fluoroquinolones and age over 65 years were associated with a higher risk of CDI due to the BI/NAP1/027 strain. Clindamycin was associated with a lower risk of CDI due to BI/NAP1/027. (Source: International Journal of Infectious Diseases)

Neonatal methicillin-resistant Staphylococcus aureus (MRSA) suppurative head and neck infections

We describe two cases at the Children's Hospital of Philadelphia of neonates requiring surgical drainage of head and neck infections. The patients consisted of 2 males, presenting 9 and 13 days of life, respectively. Both were born via Caesarean section and were full-term deliveries without any identifiable, high-risk obstetrical issues. The infection sites were submandibular and orbital. Both of the patients grew wound cultures positive for methicillin-resistant Staphylococcus aureus (MRSA), which were both sensitive to bactrim (trimetroprim-sulfamethoxazole) and in one case, resistant to clindamycin. Fevers in the neonatal period (age (Source: International Journal of Pediatric Otorhinolaryngology Extra)

Antibiotic regimens for the empirical treatment of newborn infants with necrotising enterocolitis.

CONCLUSIONS: There was insufficient evidence to recommend a particular antibiotic regimen for the treatment of NEC. There were concerns about adverse effects following the usage of clindamycin, related to the development of strictures. To address this issue a large randomised controlled trial needs to be performed. PMID: 22895960 [PubMed - in process] (Source: Cochrane Database of Systematic Reviews)<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>

Multidrug‚?�resistant coagulase‚?�negative Staphylococci in food animals

ConclusionsMultidrug resistance and resistance to non‚?�ő≤‚?�lactam antimicrobials are common in CoNS in animals. Significance and Impact of the StudyThe data improve our understanding on the extent to which CoNS contribute to the dissemination of antimicrobial resistance in the food production environment. (Source: Journal of Applied Microbiology)

Recurrent menstrual toxic shock syndrome despite discontinuation of tampon use: Is menstrual toxic shock syndrome really caused by tampons?

We present a case of recurrent MTSS initially associated with tampon use that continued to recur when tampons were discontinued, which was successfully treated with rifampicin and clindamycin. (Source: Australasian Journal of Dermatology)

Occurrence and Antimicrobial Susceptibility of Listeria monocytogenes Isolated from Brined White Cheese in Jordan

Abstract:‚?? Listeria monocytogenes is a serious foodborne pathogen that has been isolated from different dairy food products. Several foodborne outbreaks of listeriosis have been associated with consumption of cheese. The aims of this study were to determine the occurrence of L. monocytogenes and Listeria spp. in brined white cheese (BWC) sold in Jordan, and to determine the susceptibility of isolated L. monocytogenes to antimicrobials. Three hundred and fifty samples of 5 different types of BWC (akkawi, boiled, halloumi, pasteurized, and shellal) were collected from a local market in Jordan. The ISO (11290‚?�1) procedure was followed for isolation and identification of Listeria spp. from cheese samples and a polymerase chain reaction (PCR) technique was used for confirmation of L. monocy...

CLINDAMYCIN PHOSPHATEcream [Greenstone LLC]

Updated Date: Aug 15, 2012 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>

Antibiotic susceptibility profiles of oral pathogens

Abstract: Periodontitis is a bacterial disease that can be treated with systemic antibiotics. The aim of this study was to establish the antibiotic susceptibility profiles of five periodontal pathogens to six commonly used antibiotics in periodontics. A total of 247 periodontal bacterial isolates were tested for susceptibility to the six antibiotics using the Etest method. MIC50 and MIC90 values (minimum inhibitory concentrations for 50% and 90% of the organisms, respectively) were calculated. Both European Committee on Antimicrobial Susceptibility Testing (EUCAST) and Clinical and Laboratory Standards Institute (CLSI) breakpoints were used in the study to interpret results. ő≤-Lactamase production was tested when amoxicillin resistance was found. MIC90 values of the anaerobic bacteria wer...

CLINDAMYCIN (Clindamycin Phosphate) Injection, Solution, Concentrate [Hospira, Inc.]

Updated Date: Aug 10, 2012 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

Spontaneous Abscess of the Anterior Abdominal Wall Caused by Clostridium perfringens Resistant to Clindamycin

Surgical Infections , Vol. 0, No. 0. (Source: Surgical Infections)

CLINDAMYCIN (Clindamycin Phosphate) Injection, Solution, Concentrate [Hospira, Inc.]

Updated Date: Aug 7, 2012 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

CLINDAMYCIN PHOSPHATEgel [Preferred Pharmaceuticals, Inc.]

Updated Date: Aug 6, 2012 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>

Clinical and microbiological characterization of Staphylococcus lugdunensis isolates obtained from clinical specimens in a hospital in China

Conclusion: Hence, even though S. lugdunensis may be yet unrecognized and undefined in China, it still might be the infrequent cause of infection and profound multi-drug resistance in the same population. (Source: BMC Microbiology - Latest articles)

Ocular toxoplasmosis: patient age and other risk factors for a severe course of disease

Conclusion Patient age was significantly correlated with lesion size and inflammatory involvement of the anterior part of the eye. Localisation of lesions is a predictor for complications. (Source: Acta Ophthalmologica)

Staphylococcal Cassette Chromosome mec type and antibiotic susceptibility profiles of vaginal and nonvaginal MRSA clinical isolates

Abstract: Methicillin-resistant Staphylococcus aureus (MRSA) causes nosocomial and community-associated infections, representing significant healthcare concerns. Limited studies have investigated cervicovaginal MRSA colonization and antibiotic susceptibility. Upon comparing clinical cervicovaginal MRSA isolates to nonvaginal isolates by Staphylococcal Cassette Chromosome mec type, presence of Panton‚??Valentine Leukocidin toxin, antibiotic susceptibility, and presence of associated resistance genes, no significant differences were observed between the anatomical sites, but were observed between our hospital- and community-associated MRSA isolates. There was a significant increase in erythromycin resistance in our vaginal MRSA isolates compared to previous vaginal MRSA reports and an increa...

CLINDAMYCIN HYDROCHLORIDEcapsule [STAT Rx USA LLC]

Updated Date: Aug 1, 2012 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

CLINDAMYCIN HYDROCHLORIDEcapsule [Unit Dose Services]

Updated Date: Aug 1, 2012 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>

CLINDAMYCIN HYDROCHLORIDEcapsule [Major Pharmaceuticals]

Updated Date: Aug 1, 2012 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

High prevalence and resistance rates to antibiotics in anaerobic bacteria in specimens from patients with chronic balanitis.

In conclusion, anaerobes were 1.6-fold more frequent in untreated symptomatic patients compared with other patients, suggesting their participation in development of chronic balanitis. GPAs were more common than GNAs. The resistance rates to amoxicillin, clindamycin, tetracycline, and levofloxacin were high. Most active agents were metronidazole and amoxicillin/clavulanate. Resistance in anaerobes varies according to sites of specimens and years of study. PMID: 22710106 [PubMed - in process] (Source: Anaerobe)

Macrolide and tetracycline resistance in clinical strains of Streptococcus agalactiae isolated in Tunisia.

Authors: Hraoui M, Boutiba-Ben Boubaker I, Rachdi M, Slim A, Ben Redjeb S Abstract Between 2007 and 2009, 226 clinical strains of Streptococcus agalactiae, recovered from female genital specimens and from gastric fluid or ear specimens from infected newborns, were isolated at the Laboratory of Microbiology of Charles Nicolle Hospital of Tunis. They were investigated to determine the prevalence of antibiotic resistance and to characterize the mechanisms of resistance to macrolide and tetracycline. All strains were susceptible to penicillin, ampicillin and quinupristin-dalfopristin. They were resistant to chloramphenicol (3.1‚??%), rifampicin (19.1‚??%), erythromycin (40‚??%) and tetracycline (97.3‚??%); 3.1‚??% were highly resistant to streptomycin and 1.3‚??% to gentamicin. Among t...

The effectiveness of systemic antimicrobial treatment in canine superficial and deep pyoderma: a systematic review.

Conclusions‚??-‚?? There is a need for greater numbers of adequately sized, blinded, randomized controlled trials evaluating systemic antimicrobial interventions for canine pyoderma. Improved differentiation between superficial and deep pyoderma in outcome reporting, outcome measure standardization and association of outcomes with causative bacterial species and their resistance patterns are required. PMID: 22734856 [PubMed - in process] (Source: Veterinary Dermatology)

Meticillin-resistant Staphylococcus pseudintermedius: clinical challenge and treatment options.

Authors: Frank LA, Loeffler A Abstract Meticillin-resistant Staphylococcus pseudintermedius (MRSP) has emerged as a major therapeutic challenge for small animal veterinarians over the past 10‚??years and continues to spread worryingly in many countries. This review focuses on the clinical aspects of MRSP infections seen in patients with skin disease and on currently available treatment options. In addition, it discusses the implications for in-contact people, other animals and the environment, because infection control strategies are likely to have a significant impact on treatment success and prevention of spread. There is currently no indication that MRSP is more virulent than meticillin-susceptible S.¬ pseudintermedius, and reported infections have mostly been treated successful...<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>

Selection of antibiotics for meticillin-resistant Staphylococcus pseudintermedius: time to revisit some old drugs?

Authors: Papich MG Abstract The aim of this review is to consider systemic therapy options for meticillin-resistant Staphylococcus pseudintermedius (MRSP). Infections caused by MRSP in small animals - particularly dogs - have been frustrating veterinarians in recent years. After a susceptibility test is performed, veterinarians are left to select from drugs that have not been frequently encountered on a susceptibility report. Some of these are old drugs that have not been used regularly by veterinary dermatologists. As MRSP is, by definition, resistant to all ő≤-lactam antibiotics, including cephalosporins, penicillins and amoxicillin-clavulanate combinations, the ő≤-lactam drugs are not an option for systemic treatment. As most MRSPs are multidrug resistant, familiar drugs, such a...

Drug-Induced Hypersensitivity Syndrome Induced by Clindamycin.

Authors: Nakamura Y, Watamatsu K, Muto M Abstract Abstract is missing (Letter). PMID: 22855006 [PubMed - as supplied by publisher] (Source: Acta Dermato-Venereologica)

[Antibiotic treatment of hidradenitis suppurativa].

Authors: Revuz J Abstract Bacterial infection plays an important role in hidradenitis suppurativa (HS). This infection has a number of unique features: chronicity, absence of lymph node involvement, and absence in most cases of acute super-infection by Staphylococcus aureus and/or streptococci. Treatment is based mainly on antibiotics. Various bacteria are involved; they are often part of the resident flora and may combine in polymicrobial infections, and they consist mainly of two families: coagulase-negative staphylococci (CNS) and anaerobes. Numerous antibiotics are active against CNS: betalactamins, lincosamides, macrolides, rifampicin, tetracyclines and fluoroquinolones. Antibiotics active against anaerobes include metronidazole, betalactamins, lincosamides and one fluoroquino...

Root discolouration following short‚?�term application of steroid medicaments containing clindamycin, doxycycline or demeclocycline

Abstract Discolouration of teeth following application of intra‚?�canal antibiotic pastes is a clinical concern. This laboratory study compared the extent of tooth discolouration from three antibiotic pastes over 4 weeks. A total of 120 root samples were prepared and the canals filled with either Ledermix (demeclocyline), Odontopaste (clindamycin) or DoxyPaste (doxycycline). Roots were photographed before and 2 or 4 weeks after incubation at 37¬įC and 100% humidity in complete darkness in opaque containers. Digital images were standardised and assessed for changes in luminosity. Ledermix paste caused the most discolouration of the three, at both 2 and 4 weeks. There was no significant difference between DoxyPaste and Odontopaste at 2 weeks, whereas at 4 weeks, DoxyPaste caused a greater de...

Clindamycin: Acute interstitial nephritis in an elderly patient: case report

(Source: Reactions)<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>

Odontogenic infections: An 8-year epidemiologic analysis in a dental emergency outpatient care unit.

Conclusions. Early recognition, diagnosis and management of odontogenic infections are requisite for avoiding or minimizing the development of potential complications. Strategies and evidence-based protocols should be developed within the dental ambulatory care sector, advancing interdisciplinary cooperation between general dentists and oral or maxillofacial surgeons. PMID: 22816380 [PubMed - as supplied by publisher] (Source: Acta Odontologica Scandinavica)

Multidrug‚?�resistant Coagulase‚?�negative Staphylococci (CoNS) in Food Animals

ConclusionsMultidrug resistance and resistance to non ő≤‚?�lactam antimicrobials are common in CoNS in animals.Significance and Impact of the StudyThe data improve our understanding on the extent to which CoNS contribute to the dissemination of antimicrobial resistance in the food production environment.¬© 2012The Authors Journal of Applied Microbiology ¬© 2012 The Society for Applied Microbiology (Source: Journal of Applied Microbiology)

Molecular mechanism of macrolide-lincosamide resistance in Moraxella catarrhalis.

This study represents the first evidence to this effect in M. catarrhalis. PMID: 22820696 [PubMed - as supplied by publisher] (Source: Journal of Medical Microbiology)

Clindamycin-resistant methicillin-resistant Staphylococcus aureus: epidemiologic and molecular characteristics and associated clinical factors

Abstract: In this prospective, observational study of 618 consecutive adult patients with skin and soft tissue infections (SSTI) caused by methicillin-resistant Staphylococcus aureus (MRSA), the clinical characteristics, molecular epidemiology, and outcome of patients with clindamycin-resistant MRSA (n = 64) and clindamycin-susceptible MRSA (n = 554) were compared (including factors predictive of clindamycin-resistant MRSA SSTI). Patients with clindamycin-resistant MRSA were more likely to have had antibiotic exposure within 3 months (37.5% versus 17%, P < 0.01), surgery (25% versus 8%, P < 0.01), MRSA infection/colonization within 12 months (23% versus 7%, P < 0.01), or intravascular catheters (5% versus 0.5%, P = 0.02). On multivariate analysis, previous surgery (adjusted odds ratio [AOR...

Antibiotic resistance of microbial strains isolated from Korean acne patients

We examined the species of bacteria aerobically and anaerobically isolated from 100 Korean acne patients. Among the bacteria isolated, Staphylococcus epidermidis (36 patients) was the most common, followed by Propionibacterium acnes (30 patients). Eleven strains of P.¬ acnes (36.7%) and 25 strains of S.¬ epidermidis (69.4%) were resistant to one or other of the antibiotics tested. A higher proportion of P.¬ acnes isolates were resistant to clindamycin (30%) and erythromycin (26.7%), than to any other antibiotics tested (P‚??=‚??0.0003). Some S.¬ epidermidis isolates were resistant to tetracycline and doxycycline in addition to clindamycin and erythromycin. In the previous studies, few strains of P.¬ acnes were found to be resistant to any of the antibiotics, but this study shows that antib...<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>

Prospective multicentre feasibility study of a quality of care indicator for intravenous to oral switch therapy with highly bioavailable antibiotics

Conclusions This quality indicator was found to be generally feasible in hospitals across three European countries, and informative about the local need for clinical quality improvement. (Source: Journal of Antimicrobial Chemotherapy)

Efficacy and safety of a nano-emulsion gel formulation of adapalene 0.1% and clindamycin 1% combination in acne vulgaris: A randomized, open label, active-controlled, multicentric, phase IV clinical trial

Conclusions: The nano-emulsion gel formulation of adapalene and clindamycin combination appears to be more efficacious and better tolerated than the conventional formulation for the treatment of acne vulgaris in Indian patients. Further studies can elucidate the comparative treatment benefits of this nano-emulsion gel formulation. (Source: Indian Journal of Dermatology, Venereology and Leprology)

FDA approves generic version of acne treatment

FDA has approved Perrigo Company&acirc;&euro;&trade;s abbreviated new drug application for a generic version of clindamycin phosphate and benzoyl peroxide 1.2%/5% gel (Duac Gel, Stiefel Laboratories), the company recently announced in a statement. The gel is indicated for the topical treatment of inflammatory acne vulgaris. (Source: Drug Topics - Pharmacy News)

Incidence and characterization of Staphylococcus aureus in fishery products marketed in Galicia (Northwest Spain).

Authors: Vázquez-Sánchez D, López-Cabo M, Saá-Ibusquiza P, Rodríguez-Herrera JJ Abstract A total of 298 fishery products purchased from retail outlets in Galicia (NW Spain) between January 2008 and May 2009 were analyzed for the presence of Staphylococcus aureus. S. aureus was detected in a significant proportion of products (~25%). Incidence was highest in fresh (43%) and frozen products (30%), but it was high in all other categories: salted fish (27%), smoked fish (26%), ready-to-cook products (25%), non-frozen surimis (20%), fish roes (17%) and other ready-to-eat products (10%). A significant proportion of smoked fish, surimis, fish roes and other ready-to-eat products did not comply with legal limits in force. RAPD-PCR of 125 S. aureus isolated from fishery products was ca...<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>

Epidemiological and molecular characteristics of clinical isolates of Streptococcus pyogenes collected between 2005 and 2008 from Chinese children.

Authors: Liang Y, Liu X, Chang H, Ji L, Huang G, Fu Z, Zheng Y, Wang L, Li C, Shen Y, Yu S, Yao K, Ma L, Shen X, Yang Y Abstract The aim of this study was to explore the epidemiological and molecular characteristics of Streptococcus pyogenes in children from different cities in mainland China who were diagnosed with scarlet fever, impetigo and pharyngitis, as well as to detect asymptomatic carriers, between 2005 and 2008, and to compare the results with isolates from rural Chinese children with acute glomerulonephritis in 2005 and in the 1990s. Susceptibility tests to determine MICs and analysis of the presence of erythromycin-resistant genes (mefA, ermB and ermA) and emm gene typing were performed on 466 S. pyogenes isolates from Beijing, Shanghai, Chongqing and Shenzhen. Superant...

Probable clindamycin-induced ageusia, xerostomia, and burning mouth syndrome.

Authors: Rosen S, Trefflich D, Rosen MA PMID: 22764332 [PubMed - in process] (Source: The Annals of Pharmacotherapy)

Acute generalized erythematous pustulosis occurring with Hailey-Hailey disease.

Authors: Deng A, Lowitt M Abstract A 70-year-old woman urgently presented with severe eruptive skin dermatitis associated with fever and malaise 7 days after taking clindamycin for an unknown skin eruption. She had a 40-year-long history of well-controlled Hailey-Hailey disease. Physical examination revealed erythrodermic skin changes covering more than 80% of the patient's body surface, with hundreds of nonfollicular pustules. Many of the pustules fused into large bullae, involving the intertriginous as well as the extensor areas, sparing the mucosa. Her body temperature was 103 degrees F. Laboratory workup was significant for neutrophilia with a white cell count &gt; 10,000/mm3. PMID: 23008946 [PubMed - in process] (Source: Skinmed)

Antimicrobial resistance and molecular typing of Staphylococcus aureus bloodstream isolates from hospitals in Peru

Conclusions: MRSA rate among bloodstream isolates in Peru was 50%, with MLST CC5/t149/SCCmec I representing the most frequent clone. (Source: Journal of Infection)

Antiseptics and disinfectants for the treatment of bacterial vaginosis: a systematic review

Conclusion: The use of antiseptics and disinfectants for the treatment of BV has been poorly studied and most studies are somehow methodologically flawed. Limited data indicate that some antiseptics may have equal efficacy in treating BV on short term compared to treatment with clindamycin or metronidazole. Further study is however warranted with special regard to long-term efficacy and safety of antiseptics and disinfectants for vaginal use. (Source: BMC Infectious Diseases)<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>

Clindamycin: First report of Kounis syndrome leading to acute myocardial infarction: case report

(Source: Reactions)

CLINDAMYCIN PHOSPHATEcream [E. FOUGERA CO. A Division Of Fougera Pharmaceuticals Inc.]

Updated Date: Jun 21, 2012 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

Epidemiology of Clostridium difficile infections in a tertiary‚?�care hospital in Korea

Clin Microbiol InfectAbstractTo survey healthcare‚?�associated Clostridium difficile infection (HA‚?�CDI) in a 900‚?�bed tertiary‚?�care hospital, we prospectively investigated the epidemiology of CDI and distribution of PCR‚?�ribotypes. From February 2009 through January 2010, all patients with HA‚?�CDI were enrolled. Epidemiological information and prescription records for antibiotics were collected. The C.‚??difficile isolates were characterized using reference strains and were tested for antibiotic susceptibility. During the survey, incidence of HA‚?�CDI was 71.6 per 100‚??000 patient‚?�days. In total, 140 C.¬ difficile isolates were obtained from 166 patients with HA‚?�CDI. The PCR‚?�ribotyping yielded 38 distinct ribotypes. The three most frequently found ribotypes made up 56.4% of a...

Active infective endocarditis due to Erysipelothrix rhusiopathiae: zoonosis caused by vancomycin-resistant gram-positive rod

Abstract&nbsp;&nbsp;A 42-year-old female who was a voluntary worker in a school for handicapped children was referred to us for surgery for active infective endocarditis. Trans-esophageal echocardiography showed 2 large mobile vegetations on the aortic valve and severe aortic regurgitation. Aortic valve replacement was performed to prevent septic embolism and deterioration of congestive heart failure. The empiric therapy with vancomycin, ampicillin, and gentamycin was initiated because a pathogen was not identified. But Erysipelothrix rhusiopathiae (gram-positive rod) was isolated on the 4th day after surgery. The target therapy with penicillin G and clindamycin was started and continued for 4&nbsp;weeks after surgery. The inflammatory parameters improved steadily and the patient was ...

CLINDAMYCIN HYDROCHLORIDEcapsule, Gelatin Coated [CorePharma, LLC]

Updated Date: Jun 5, 2012 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>

Limited course of antibiotic treatment for chorioamnionitis.

CONCLUSION: : A limited course of antibiotics was sufficient for virtually all patients (99%) with chorioamnionitis who had a vaginal delivery. However, a subset of patients who delivered by cesarean may have benefited from a more extended course of antibiotic therapy. LEVEL OF EVIDENCE: : III. PMID: 22617573 [PubMed - in process] (Source: Obstetrics and Gynecology)

Investigation of the antibiotic resistance and biofilm formation of Staphylococcus aureus strains isolated from gangrenous mastitis of ewes.

In this study, Staphylococcus aureus strains (n = 110) isolated from seven ewe flocks in Sanliurfa, Turkey were screened for antibiotic resistance and biofilmforming ability as well as for genes associated with antibiotic resistance and biofilm-forming ability. All isolates were found to be susceptible to oxacillin, gentamicin, clindamycin, cefoxitin, tetracycline, vancomycin, amoxicillin-clavulanic acid, ciprofloxacin and sulphamethoxazole-trimethoprim. The percent proportions of strains resistant to penicillin G, ampicillin and erythromycin were 27.2% (n = 30), 25.4% (n = 28) and 6.3% (n = 7), respectively. Regarding the antibiotic resistance genes, 32 (29%) isolates carried the blaZ and 8 (7.2%) the ermC gene. Other resistance genes were not detected in the isolates. All isolates showed...

Sensitivity of Human Strains of Oxalobacter formigenes to Commonly Prescribed Antibiotics

Conclusion: Four human strains of Oxf are sensitive to a number of antibiotics commonly used in clinical practice; however, minimum inhibitory concentrations differ between strains. (Source: Urology)

Clindamycin Plus Quinine for Treating Falciparum MalariaClindamycin Plus Quinine for Treating Falciparum Malaria

Is clindamycin plus quinine an adequate alternative treatment for uncomplicated malaria? Malaria Journal (Source: Medscape Today Headlines)

Detection of various types of resistance patterns and their correlation with minimal inhibitory concentrations against clindamycin among methicillin-resistant Staphylococcus aureus isolates

Conclusion: Detection of iMLS B resistance among MRSA helps to avoid treatment failure with clindamycin. Studying the subpopulation inside the clindamycin-sensitive zone raises the question of existence of hetero-resistance or some other mechanism, which needs further study. (Source: Indian Journal of Medical Microbiology)<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>

Molecular characterization and clonal genetic diversity of methicillin-resistant Staphylococcus aureus of pig origin in Taiwan.

In conclusion, this study reported the first identified LA-MRSA clone of MDR-ST9-t899-V lacking ccrC dominant in pig farms in western Taiwan that differed from ST398 in Europe and North America. Close monitoring of this MDR unique clone is warranted to survey its spread from livestock to humans. PMID: 22640551 [PubMed - as supplied by publisher] (Source: Comparative immunology, microbiology and infectious diseases.)

The Cephalosporin Use in the Penicillin Allergic Patient

Many patients present for orthopedic surgeries with penicillin or cephalosporin allergies. These allergies are unbiquous and range from hives, shortness of breath to an upset stomach. The pre-operative antibiotic of choice for these procedures is Ancef. In the past, these ‚??allergic‚?� patients would be treated with vancomycin or clindamycin pre-operatively. This last minute antibiotic change lead to increase in pre-op nursing and pharmacy staffing time, delayed surgeries, operating room scheduling issues and increased risk of complications for the patient (ie, MDRO, renal issues or c-diff infections etc). (Source: American Journal of Infection Control)

Azithromycin/clindamycin: Clostridium difficile infection: case report

(Source: Reactions)

CLINDAMYCIN PHOSPHATElotion CLINDAMYCIN PHOSPHATEsolution CLINDAMYCIN PHOSPHATEgel [E. FOUGERA CO. A Division Of Fougera Pharmaceuticals Inc.]

Updated Date: May 21, 2012 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

Epidemiology of Clostridium difficile infections in a tertiary care hospital in Korea

AbstractClostridium difficile infection (CDI) is one of the most important hospital infections, and during the past decade its incidence has increased markedly worldwide. Prior exposure to antimicrobials, which can disrupt the normal flora, is the main risk factor for CDI. Clindamycin and extended‚?�spectrum cephalosporins (ESC) are the antibiotics most frequently implicated in CDI, whereas fluoroquinolones are considered risk factors for CDI caused by the hypervirulent BI/NAP1/027 (ribotype 027) strains that have become resistant to newer fluoroquinolones (moxifloxacin, levofloxacin, and gatifloxacin). Additional risk factors for CDI include age, underlying co‚?�morbidities, and hospital admission¬© 2012 The Authors Clinical Microbiology and Infection ¬© 2012 European Society of Clinical ...<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>

Genotypic characterization and safety assessment of lactic acid bacteria from indigenous African fermented food products

Conclusions: The resistance to kanamycin and vancomycin is probably an intrinsic feature since similarobservations were reported in the literature for LAB. Low prevalence of pathogenicityindicator traits were observed among the isolates especially with the presence of poorhaemolytic activities and they could therefore be considered as interesting candidates forselection of starter cultures or probiotics for different applications. (Source: BMC Microbiology - Latest articles)

Multidrug-resistant clones of community-associated MRSA isolated from Chinese children and the resistance genes to clindamycin and mupirocin.

This study aims to correlate the multidrug resistance (MDR) and sequence type (ST) clones of community-associated methicillin-resistant Staphylococcus aureus (CA-MRSA), to identify the genes responsible for clindamycin and mupirocin resistance in Staphylococcus aureus (SA) isolated from pediatric hospitals in mainland China. Up to 435 SA isolates were collected. Compared with community-associated methicillin-susceptible Staphylococcus aureus (CA-MSSA), the resistance rates of CA-MRSA to ciprofloxacin, chloramphenicol, gentamicin and tetracycline were higher (19.0% vs 2.6%, P&lt;0.001; 14.7% vs 3.1%, P&lt;0.001; 14.7% vs 3.1%, P&lt;0.01; and 46.0% vs 13.3%, P&lt;0.001). Compared with hospital-associated MRSA (HA-MRSA), the resistance rates of CA-MRSA to ciprofloxacin, gentamicin, rifampin, ...

In reply

Synovitis, acne, pustulosis, hyperostosis, osteitis (SAPHO) syndrome affecting the mandible is rare. Primarily for this reason, there is still no generally accepted treatment strategy. Deng et al. reported an interesting case of a patient suffering from SAPHO syndrome involving the mandible. They presented the results of a single case treated with roxithromycin and concluded that this conservative approach seemed to be effective. This is consistent with other reports in which the usefulness of antibiotic treatment (roxithromycin, tetracycline, clindamycin, macrolides) has been described. Deng et al. considered that medical treatment should be attempted before considering surgical intervention because of the potentially severe complications, including paresthesia of the lower lip, facial as...

Association between PCR ribotypes and antimicrobial susceptibility among Clostridium difficile isolates from healthcare-associated infections in South Korea

In conclusion, the common ribotypes 018, 017 and 001 of C. difficile have high rates of resistance to clindamycin and moxifloxacin, but differ greatly in the frequency of rifaximin resistance. (Source: International Journal of Antimicrobial Agents)

Methicillin-resistant Staphylococcus aureus bacteremia at a university hospital in Japan

In this study, we assessed the clinical characteristics and optimum management of 115 patients with MRSA bacteremia who were admitted to Osaka University Hospital between January 2006 and December 2010. Sixty-nine of the patients survived and 46 died of heart failure or renal failure. The nonsurvivors had reduced levels of platelets and albumin, and increased aspartate aminotransferase, total bilirubin, blood urea nitrogen, and creatinine levels. Other causes of death included sepsis, septic shock plus respiratory failure, disseminated intravascular coagulation, and unknown causes. However, a significant number of those whose infections were catheter-derived survived. Nonsurvivors were more often administered catecholamines and consultation with an infection-control team (ICT) was s...<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>

Sulphadiazine-induced obstructive renal failure complicating treatment of HIV-associated toxoplasmosis

A patient with newly-diagnosed HIV infection and biopsy-proven cerebral toxoplasmosis was treated with sulphadiazine and pyrimethamine. Despite adequate hydration and daily examination of urine for sulphadiazine crystals obstructive uropathy due to bilateral ureteric stones with hydronephrosis occurred, resulting in rapid onset renal failure. Sulphadiazine was discontinued and clindamycin was substituted. With intravenous fluid hydration and bilateral nephrostomies the urolithiasis resolved. This case serves to remind clinicians of the need for vigilance when treating cerebral toxoplasmosis with sulphadiazine, in order to avoid this potentially serious complication of treatment. (Source: International Journal of STD and AIDS)

Clinical and microbiologic characteristics of tcdA-negative variant clostridium difficile infections

Conclusions: The clinical course of A-B+ CDI is not different from that of A+B+ CDI. Clindamycin use is asignificant risk factor for the acquisition of tcdA-negative variant strains. (Source: BMC Infectious Diseases)

VELTIN (Clindamycin Phosphate And Tretinoin) Gel [Stiefel Laboratories Inc]

Updated Date: May 8, 2012 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

A systematic review of the safety and efficacy of artemether-lumefantrine against uncomplicated Plasmodium falciparum malaria during pregnancy

There is evidence to suggest that the pharmacokinetics of anti-malarial drugs may change in pregnancy, although the majority of studies report high cure rates and adequate tolerability. The paper reinforces the WHO recommendation to treat uncomplicated falciparum malaria with quinine plus clindamycin in early pregnancy and ACT in later pregnancy. (Source: Malaria Journal)

Characterization of MLSb resistance among Staphylococcus aureus and Staphylococcus epidermidis isolates carrying different SCCmec types

ABSTRACTThis work characterizes MLSb resistance in 39 methicillin‚?�resistant Staphylococcus aureus (MRSA) and 32 Staphylococcus epidermidis (MRSE) isolates. For 21 erm(A) gene encoding MRSA isolates 71.4% carried the SCCmecIII, while for 12 isolates carrying the erm(C) gene 83.3% had the SCCmecIV. Among the 25 MRSE isolates positive for the erm(C) gene 80% had the SCCmecIV or nontypeable cassettes. Isolates carrying these genes presented MIC90‚?•256őľg/ml to erythromycin and clindamycin. The msr(A) gene was associated with low MIC90 to these drugs. The erm(A) gene was associated to SCCmecIII in MRSA isolates, while the erm(C) gene was related to SCCmecIV in both MRSA and MRSE isolates. (Source: Microbiology and Immunology)<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>

Heat stable antimicrobial activity of Burkholderia gladioli OR1 against clinical drug resistant isolates.

We report here the antimicrobial activity of B. gladioli against drug resistant bacterial pathogens. Methods: The bacterial culture was identified using morphological, biochemical and 16S rRNA gene sequencing techniques. The antimicrobial activity of the identified organism against a range of microbial pathogens was checked by Kirby-Bauer's disc diffusion method. The antimicrobial compounds in the cell free supernatant were chloroform-extracted and separated by thin layer chromatography (TLC). Results: B. gladioli OR1 exhibited broad spectrum antimicrobial activity against drug resistant clinical isolates belonging to various genera of bacteria (Staphylococcus, Enterobacter, Enterococcus, Acinetobacter and Citrobacter) and a fungus (Candida). Based on TLC profile and bioautography studies,...

Antibiotic susceptibility in prostate‚?�derived Propionibacterium acnes isolates

The aim of this study was to determine antibiotic susceptibility of Propionibacterium acnes isolates from prostate. Prostate‚?�derived P. acnes isolates (n¬ =¬ 24, Ume√• & √?rebro, Sweden, 2007‚??2010) and a panel of control strains (n¬ =¬ 25, Sweden) collected from skin and deep infections were assessed for resistance to penicillin G, piperacillin‚??tazobactam, imipenem, gentamicin, azithromycin, erythromycin, vancomycin, ciprofloxacin, moxifloxacin, tetracycline, tigecycline, fusidic acid, clindamycin, rifampicin, linezolid, daptomycin, trimethoprim‚??sulfamethoxazole, and metronidazole. In addition, the isolates were tested for inducible clindamycin resistance. All prostate derived P. acnes isolates displayed wild‚?�type distribution of MIC‚?�values, without evidence of acquired res...

CLINDAMYCIN HYDROCHLORIDEcapsule [Teva Pharmaceuticals USA Inc]

Updated Date: Apr 26, 2012 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

Macrolide and Tetracycline Resistance in Clinical Strains of Streptococcus agalactiae Isolated in Tunisia.

Authors: Hraoui M, Boutiba-Ben Boubaker I, Rachdi M, Slim A, Ben Redjeb S Abstract Between 2007 and 2009, 226 clinical strains of Streptococcus agalactiae, recovered from women genital specimens and from gastric fluids or ear specimens of infected newborns were isolated at the laboratory of Microbiology of Charles Nicolle Hospital of Tunis. They were investigated to determine the prevalence of antibiotic resistance and to characterize the mechanisms of resistance to macrolide and tetracycline. All strains were susceptible to penicillin, ampicillin and quinupristun-dalfopristin. They were resistant to chloramphenicol (3.1%), rifampin (19.1%), erythromycin (40%) and tetracycline (97.3%). 3.1% were highly resistant to streptomycin and 1.3% to gentamicin. Among the erythromycin resista...

clindamycin and benzoyl peroxide gel, Benzaclin, Acanya, Duac

Title: clindamycin and benzoyl peroxide gel, Benzaclin, Acanya, DuacCategory: MedicationsCreated: 9/30/2001 2:36:00 PMLast Editorial Review: 4/23/2012 12:00:00 AM (Source: MedicineNet Skin General)<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>

Do automated text messages increase adherence to acne therapy? Results of a randomized, controlled trial

Conclusions: Electronic reminders in the form of daily, customized text messages were not associated with significant differences in adherence to topical medications in patients with mild to moderate acne and had no significant effect on therapeutic response. (Source: Journal of the American Academy of Dermatology)

Listeria fleischmannii sp. nov., isolated from cheese.

Authors: Bertsch D, Rau J, Eugster MR, Haug MC, Lawson PA, Lacroix C, Meile L Abstract A polyphasic study was performed on three isolates (LU2006-1(T), LU2006-2 and LU2006-3), which were sampled independently from cheese in western Switzerland in 2006, as well as a fourth isolate (A11-3426) detected in 2011. They could all be assigned to the genus Listeria but not to any known species. Phenotypic and chemotaxonomic data were compatible with other Listeria species. Phylogenetic analyses revealed the closest relationship to members of the genus Listeria, however DNA-DNA hybridizations demonstrated that the isolates did not belong to any currently described species. Cell wall binding domains of L. monocytogenes bacteriophage endolysins were able to attach to the isolates, confirming t...

CLINDAMYCIN HYDROCHLORIDEcapsule [Cardinal Health]

Updated Date: Apr 18, 2012 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

A Systematic Review of Treatments for Hidradenitis Suppurativa [Study]

Conclusions&nbsp; Shown to be effective treatments for HS were a clindamycin-rifampin combination regimen, a course of infliximab, monthly Nd:YAG laser sessions, and surgical excision and primary closure with a gentamicin sulfate&ndash;collagen sponge. Most therapies used to treat HS were supported by limited or weak scientific evidence. A treatment approach is presented based on the evidence and on clinical experience at the Follicular Disorders Clinic, Department of Dermatology, Henry Ford Hospital, Detroit, Michigan. This review emphasizes the need for large randomized controlled trials to evaluate treatment options for HS. (Source: Archives of Dermatology)<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>

Characterizations of Clinical Isolates of Clostridium difficile by Toxin Genotypes and by Susceptibility to 12 Antimicrobial Agents, Including Fidaxomicin (OPT-80) and Rifaximin: A Multicenter Study in Taiwan.

This study found the diversity of toxigenic and nontoxigenic strains of C. difficile found in the healthcare setting in Taiwan. All isolates tested were susceptible to metronidazole and vancomycin. Fidaxomicin exhibited potent in vitro activity against all isolates tested, while more than 10% of Taiwanese isolates with rifaximin MICs of ‚?•128 őľg/ml needs more concerns. PMID: 22508299 [PubMed - as supplied by publisher] (Source: Antimicrobial Agents and Chemotherapy)

MRSA Rates and Antibiotic Susceptibilities from Skin and Soft Tissue Cultures in a Suburban ED

Conclusions: There has been a significant increase in the rates of MRSA SSTIs in a suburban ED, yet only 1 in 4 SSTIs are caused by MRSA. Both MRSA and MSSA are completely susceptible to vancomycin, linezolid, rifampin, nitrofurantoin, and chloramphenicol. Gentamicin, tetracycline, and TMP-SMZ cover > 97% of both isolates. (Source: The Journal of Emergency Medicine)

CLINDAMYCIN PHOSPHATEcream [Preferred Pharmaceuticals, Inc]

Updated Date: Apr 10, 2012 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

Clindamycin: Oesophageal ulcer: case report

(Source: Reactions)<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>

Prevalence, bacterial causes, and antimicrobial susceptibility profile of mastitis isolates from cows in large-scale dairy farms of Northern Ethiopia

Abstract&nbsp;&nbsp;The study was undertaken to determine the prevalence of bovine mastitis, isolate mastitis causing bacteria, assess the association of some risk factors, and determine the antibiotic resistance pattern of bacterial isolates in cows in large-scale dairy farms of Northern Ethiopia. A total of 305 lactating and nonlactating cows were included in the present study. The overall prevalence of clinical and subclinical mastitis was 3.6 and 33.8&nbsp;%, respectively. The quarter level prevalence was 15.4&nbsp;%; from which, 11.9 and 1.1&nbsp;% were subclinical form and blind teat, respectively, while the remaining 2.4&nbsp;% were of clinical form. Staphylococcus aureus accounted for 36&nbsp;% of the isolates followed by Escherichia coli (27.3&nbsp;%). Risk factors including a...

Antimicrobial activity of the novel pleuromutilin antibiotic BC-3781 against organisms responsible for community-acquired respiratory tract infections (CARTIs)

Conclusions BC-3781 was very active against organisms commonly associated with CARTIs and its activity was not negatively influenced by resistance to other antimicrobials. (Source: Journal of Antimicrobial Chemotherapy)

Population Pharmacokinetics of Clindamycin orally and intravenously administrated in osteomyelitis patients.

Conclusions: The current recommendation of 600 mg (TID) seems to be effective up to 75kg; the dose should be raised to 900 mg (TID) thereafter. These assumptions should be prospectively confirmed.© 2012 The Authors. British Journal of Clinical Pharmacology © 2012 The British Pharmacological Society (Source: British Journal of Clinical Pharmacology)

Pneumocystis jirovecii: a peculiar fungus posing particular problems for therapy and prophylaxis

SummaryPneumocystis spp. are peculiar fungi, because they lack ergosterol in their cytoplasmic membrane. Furthermore, they go through various sexual and non‚?�sexual stages in a living host; the cysts, which are able to survive in the environment, are the infectious agents. The various species are more or less specific for a mammalian host. Pneumocystis jirovecii is pathogenic for humans. Transient colonisation of children and adults with this fungus occurs frequently. As a typical opportunist it can induce an overt disease in immunocompromised patients only. In particular those patients with an impaired cell‚?�mediated immune system, namely AIDS patients or transplant recipients taking immunosuppressive agents, are affected. The leading clinical feature is a bilateral interstitial pneumon...<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>

Meticillin-resistant Staphylococcus pseudintermedius: clinical challenge and treatment options.

Authors: Frank LA, Loeffler A Abstract Meticillin-resistant Staphylococcus pseudintermedius (MRSP) has emerged as a major therapeutic challenge for small animal veterinarians over the past 10‚??years and continues to spread worryingly in many countries. This review focuses on the clinical aspects of MRSP infections seen in patients with skin disease and on currently available treatment options. In addition, it discusses the implications for in-contact people, other animals and the environment, because infection control strategies are likely to have a significant impact on treatment success and prevention of spread. There is currently no indication that MRSP is more virulent than meticillin-susceptible S.¬ pseudintermedius, and reported infections have mostly been treated successful...

CLINDAMYCIN (Clindamycin Phosphate) Injection, Solution [Sagent Pharmaceuticals]

Updated Date: Apr 2, 2012 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

Pneumocystis jirovecii: a peculiar fungus posing particular problems for therapy and prophylaxis

SummaryPneumocystis spp. are peculiar fungi, because they lack ergosterol in their cytoplasmic membrane. Furthermore, they go through various sexual and non‚?�sexual stages in a living host; the cysts, which are able to survive in the environment, are the infectious agents. The various species are more or less specific for a mammalian host. Pneumocystis jirovecii is pathogenic for humans. Transient colonisation of children and adults with this fungus occurs frequently. As a typical opportunist it can induce an overt disease in immunocompromised patients only. In particular those patients with an impaired cell‚?�mediated immune system, namely AIDS patients or transplant recipients taking immunosuppressive agents, are affected. The leading clinical feature is a bilateral interstitial pneumon...

Clinical audit of the microbiology of otorrhoea referred to a tertiary hospital in Singapore.

Conclusion: The common microorganisms involved in otorrhoea in Singapore are P. aeruginosa, Aspergillus and S. aureus. Resistant strains of Pseudomonas spp. are now present. Methicillin-resistant S. aureus is increasingly prevalent and highly sensitive to vancomycin. Aminoglycoside and fluoroquinolone-containing eardrops are suitable first-line topical antimicrobials. Cloxacillin may be started should a concomitant oral antimicrobial be warranted empirically or for S. aureus infections. Otomycosis should be considered in patients who show no improvement with antibiotics. PMID: 22511046 [PubMed - in process] (Source: Singapore Medical Journal)<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>

Evaluation of antimicrobial activity of certain combinations of antibiotics against in vitro Staphylococcus epidermidis biofilms.

The objective of this study was to compare susceptibilities of biofilm-grown cells to single antibiotic and in combination with others to identify those that were effective against S. epidermidis biofilms. Methods: Biofilms were grown in the MBEC‚?Ę assay system. The use of this methodology allowed a rapid testing of an array of antibiotics alone (eight) and in combination (25 double combinations). The antibacterial effect of all treatments tested was determined by colony forming units (cfu) enumeration method. Results: The MBEC‚?Ę assay system produced multiple and reproducible biofilms of S. epidermidis. Although none of the antibiotics tested have demonstrated an antimicrobial effect (log reduction &gt;3) against all S. epidermidis isolates biofilms, but combinations containing rifampi...

CLINDAMYCIN HYDROCHLORIDEcapsule [Preferred Pharmaceuticals, Inc]

Updated Date: Mar 30, 2012 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

In vitro antimicrobial activity of pannarin alone and in combination with antibiotics against methicillin-resistant Staphylococcus aureus clinical isolates

Abstract: The in vitro antimicrobial activities of pannarin, a depsidone isolated from lichens, collected in several Southern regions of Chile (including Antarctica), was evaluated alone and in combination with five therapeutically available antibiotics, using checkerboard microdilution assay against methicillin-resistant clinical isolates strains of Staphylococcus aureus. MIC90, MIC50, as well as MBC90 and MBC50, were evaluated. A moderate synergistic action was observed in combination with gentamicin, whilst antagonism was observed in combination with levofloxacin. All combinations with erythromycin were indifferent, whilst variability was observed for clindamycin and oxacillin combinations. Data from checkerboard assay were analysed and interpreted using the fractional inhibitory concen...

Clindamycin: Exanthematous rash: 2 case reports

(Source: Reactions)

Clostridium difficile genotypes other than ribotype 078 that are prevalent among human, animal and environmental isolates

Conclusion: Our results show that many other types in addition to PCR Ribotype 078 are shared between humans and animals and that the most prevalent genotypes in humans have the ability to survive also in the environment and several animal hosts. The genetic relatedness observed with PFGE suggests that transmission of given genotype from one reservoir to the other is likely to occur. (Source: BMC Microbiology - Latest articles)<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>

Effects of probiotics and antibiotics on the intestinal homeostasis in a computer controlled model of the large intestine

Conclusions: Administration of VSL#3 parallel with the clindamycin therapy had a beneficial and stabilizing effect on the intestinal metabolic homeostasis by decreasing toxic metabolites and protecting the endogenic microbiota from destruction. Probiotics could be a reasonable strategy in prevention of antibiotic associated disturbances of the intestinal homeostasis and disorders. (Source: BMC Microbiology - Latest articles)

Conference presentations: Two combination acne gels incorporating clindamycin do well in phase III trials

Source: Reuters Health News Area: News Data from two phase III trials presented at the American Academy of Dermatology's annual conference have shown that two different gels for treating acne vulgaris, each combining clindamycin with another agent, performed well in 12-week late-stage trials. &#160; In one trial, a combination of clindamycin phosphate 1.2% and tretinoin 0.025%, was associated with a 52.1% reduction in acne lesions in an open-label study of 154 patients in Brazil. In a separate double-blind, parallel-group, vehicle-controlled study, Stiefel Laboratories' combination of clindamycin phosphate 1.2% and benzoyl peroxide 3% was associated with acne improvement by two grades out of four in 39% of 1315 patients. In both trials, the rate of adverse events was low, and both gel...

Risk factors for Clostridium difficile toxin-positive diarrhea: a population-based prospective case‚??control study

Two acne gels that include clindamycin do well in phase III trials

NEW YORK (Reuters Health) - Two different gels for treating acne vulgaris, each combining clindamycin with another agent, performed well in 12-week late-stage trials reported at the American Academy of Dermatology's annual conference in San Diego this week. (Source: Modern Medicine)

Tooth discolouration: Staining effects of various sealers and medicaments

AbstractThe aim of this investigation was to quantify the discolouration of tooth roots caused by various medicaments and sealers. The roots of extracted teeth were chemo‚?�mechanically prepared and the smear layer removed. The roots were filled with either Multi‚?�Cal (Pulpdent Corporation, Watertown, MA, USA), Ledermix (Lederle Laboratories, Wolfratshausen, Germany), 2% chlorhexadine acetate in polyethylene glycol (PEG), 5% clindamycin in PEG, PEG alone (as a vehicle control), sealers AH26 (De Trey Dentsply, Zurich, Switzerland), AH Plus (De Trey Dentsply), an experimental epoxy resin with zirconium dioxide (Millenium Chemicals, Rockingham, Western Australia) or Araldite (Selleys Pty Ltd, Sydney, Australia). The roots were maintained at 37¬įC in dark humid conditions and standardised ima...<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>

Epidemiological and molecular characteristics of clinical isolates of Streptococcus pyogenes from Chinese children between 2005 and 2008.

Authors: Liang Y, Liu X, Chang H, Ji L, Huang G, Zhou F, Zheng Y, Wang L, Li C, Shen Y, Yu S, Yao K, Ma L, Shen X, Yang Y Abstract To explore the epidemiological and molecular characteristics of Streptococcus pyogenes in children from different cities in the mainland China who were diagnosed with scarlet fever, impetigo, and pharyngitis, as well as asymptomatic carriers, between 2005-2008; and to compare results with isolates from rural Chinese children with acute glomerulonephritis in 2005 and the 1990s. Susceptibility tests with minimal inhibitory concentrations (MICs), erythromycin-resistant genes (mefA, ermB, and ermA), and emm typing were performed on 466 S. pyogenes isolates from Beijing, Shanghai, Chongqing, and Shenzhen. Superantigen genes (speA and speC) were examined by p...

Tooth discolouration: Staining effects of various sealers and medicaments

AbstractThe aim of this investigation was to quantify the discolouration of tooth roots caused by various medicaments and sealers. The roots of extracted teeth were chemo‚?�mechanically prepared and the smear layer removed. The roots were filled with either Multi‚?�Cal (Pulpdent Corporation, Watertown, MA, USA), Ledermix (Lederle Laboratories, Wolfratshausen, Germany), 2% chlorhexadine acetate in polyethylene glycol (PEG), 5% clindamycin in PEG, PEG alone (as a vehicle control), sealers AH26 (De Trey Dentsply, Zurich, Switzerland), AH Plus (De Trey Dentsply), an experimental epoxy resin with zirconium dioxide (Millenium Chemicals, Rockingham, Western Australia) or Araldite (Selleys Pty Ltd, Sydney, Australia). The roots were maintained at 37¬įC in dark humid conditions and standardised ima...

Susceptibility testing of Atopobium vaginae for dequalinium chloride

Conclusions: This study demonstrated that dequalinium chloride inhibits and kills clinical isolates of A. vaginae at concentrations similar to those of clindamycin and lower than those of metronidazole. (Source: BMC Research Notes)

To-Go medications for decreasing ED return visits

Conclusions: For a 1-year expense of $1123, we demonstrated a 50% reduction in ED return visits for patients who were given a free, complete course of antibiotics at discharge for select conditions. (Source: The American Journal of Emergency Medicine)

Characterization of Methicillin‚?�Resistant Staphylococcus aureus Isolates from Pig Carcasses in Hong Kong

This study describes the isolation and characterization of methicillin‚?�resistant Staphylococcus aureus (MRSA) from slaughtered pigs sampled from local markets in Hong Kong. The nares of 400 slaughtered pigs were cultured and MRSA isolates characterized for the presence of antibiotic‚?�resistance determinants, toxins and SCCmec and spa types using PCR. Clonality was investigated using PFGE and MLST. The prevalence of MRSA colonization of slaughter pigs was 39.3%, the majority (92%) harbouring SCCmec type IVb. Of the 157 samples yielding MRSA, 13 had two distinct MRSA strains present. Spa type t899 was predominant, with only 5/170 isolates displaying closely related types (t4474, t1939, t2922 and t5390). PFGE with sma1 and MLST confirmed the strains as ST9. Most isolates were multidrug res...<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>

Occurrence and characterization of Listeria spp. in ready-to-eat retail foods from¬ Vancouver, British Columbia.

Novel anti‚?�acne actions of nadifloxacin and clindamycin that inhibit the production of sebum, prostaglandin E2 and promatrix metalloproteinase‚?�2 in hamster sebocytes

AbstractAcne vulgaris is characteristic of excess sebum production and the induction of inflammatory reactions, for example, the augmentation of cytokine, prostaglandin (PG) and matrix metalloproteinase (MMP) production in sebaceous glands and pilosebaceous units. As Propionibacterium acnes is considered to be involved in the aggravation of acne vulgaris, antimicrobial agents have been found to be effective for treating acne leading to the remission of inflammation. However, it is not fully understood whether antimicrobial agents influence sebum production and/or the inflammatory reactions in sebaceous gland cells (sebocytes). In the present study, topical antimicrobial agents such as nadifloxacin (NDFX) and clindamycin (CLDM) decreased the production of triacylglycerols (TG), which are a ...

CLEOCIN PHOSPHATE (Clindamycin Phosphate) Injection, Solution [Pharmacia And Upjohn Company]

Updated Date: Mar 2, 2012 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>

CLINDESSE (Clindamycin Phosphate) Cream [Ther-Rx Corporation]

Updated Date: Mar 2, 2012 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

[Phenotypes and mechanisms of resistance to macrolides and lincosamides in Streptococcus agalactiae isolates with clinical significance in an eight-year period (2002-2010)].

Conclusions. Macrolide resistance in our area is similar to that observed in the rest of Spain, but there has been no increase in the incidence rate along the study period. PMID: 22488541 [PubMed - in process] (Source: Revista Espanola de Quimioterapia)

Inhibition of Propionibacterium acnes lipase by extracts of Indian medicinal plants

This study reports for the first time the novel antilipase activity of chebulagic acid (IC50: 60‚??őľmol‚??L‚??1) with minimum inhibitory concentration value of 12.5‚??őľg‚??mL‚??1 against P.¬ acnes. The inhibitory potential of plant extracts was further confirmed by plate assay. The organism was grown in the presence of subinhibitory concentrations of extracts from P.¬ kurroa, V.¬ negundo, T.¬ chebula, E.¬ ribes and antibiotics such as clindamycin and tetracycline. Extract from T.¬ chebula showed significant inhibition of lipase activity and number of P.¬ acnes. (Source: International Journal of Cosmetic Science)

[Use of the rapid antigen technique in the diagnosis of Streptococcus pyogenes pharyngotonsillitis.]

CONCLUSIONS: The rapid antigen test can lead to a better use of antibiotics. Its use in Paediatric Primary Health Care could be useful when, as when the result is negative, there would be no need to confirm by a culture, in those Health Centres with difficult access to laboratory. PMID: 22386535 [PubMed - as supplied by publisher] (Source: Anales de Pediatria)

ACANYA (Clindamycin Phosphate And Benzoyl Peroxide) Gel [Coria Laboratories]

Updated Date: Feb 27, 2012 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>

Is methicillin-resistant Staphylococcus aureus involved in community acquired skin and soft tissue infections?: Experience from a tertiary care centre in Mumbai

Conclusions: In CA SSTIs, methicillin-susceptible S. aureus is the predominant pathogen. Penicillinase-resistant penicillins, clindamycin and erythromycin in that order can be used as suitable antimicrobials for empiric therapy. D test should be carried out routinely. No CA MRSA was detected in the present series. (Source: Journal of Postgraduate Medicine)

Molecular epidemiologic analysis of Staphylococcus aureus isolated from four burn centers

In this study, the prevalent clone of MRSA among four burn centers was found to be SCCmec III (spa-type t030, agr I), which is resistant to 4 kinds of antimicrobials including erythromycin, clindamycin, kanamycin and mupirocin. Discrepancy between mecA detection and conventional tests used for MRSA identification was observed unintentionally. Our data demonstrated that the overall prevalence rate of MRSA was 55.3%, and drugs such as sulfamethoxazole/trimethoprim, linezolid and fusidic acid are efficient antibiotic options for treating S. aureus or MRSA infections among four burn centers studied in present investigation. (Source: Burns : Journal of the International Society for Burn Injuries)

Isolation, speciation, and antibiogram of clinically relevant non-diphtherial Corynebacteria (Diphtheroids)

Conclusion: This study was an attempt to establish the clinical significance of coryneform organisms. The high level of resistance shown by this group to some of the common antibacterial agents highlights the importance of processing these isolates in select conditions to guide the clinicians towards an appropriate therapy. (Source: Indian Journal of Medical Microbiology)

Microbiological Analysis of a Prospective, Randomized, Double-Blind Trial Comparing Moxifloxacin and Clindamycin in the Treatment of Odontogenic Infiltrates and Abscesses (MOCLI Study).

In this study S. anginosus group and hemolytic streptococci were clearly associated with odontogenic abscesses. Our analysis suggests that viridans streptococci and Neisseria spp. have a decisive role in the etiology of odontogenic infiltrates. MXF's high in vitro activity against odontogenic bacteria corresponds well to its clinical results in the treatment of odontogenic abscesses and infiltrates. PMID: 22354306 [PubMed - as supplied by publisher] (Source: Antimicrobial Agents and Chemotherapy)

CLINDAMYCIN (Clindamycin Phosphate) Injection, Solution [Sagent Pharmaceuticals]

Updated Date: Feb 17, 2012 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>

Successful pregnancy in a patient suffering from recurrent mid‚?�trimester miscarriage with C9 deficiency after receiving cervical cerclage followed by clindamycin and progesterone: A case report

AbstractComplement component 9 (C9) deficiency is relatively common, especially in Japan. Here we present the case of a 27‚?�year‚?�old Japanese woman whose obstetric history involved three mid‚?�trimester miscarriages (at 22‚??weeks', 18‚??weeks' and 21‚??weeks' gestation) and one early spontaneous miscarriage. Her fifth pregnancy was successfully managed by cervical cerclage at 13‚??weeks' gestation, followed by clindamycin administration (600‚??mg/day for 7‚??days) and progesterone injections (250‚??mg/week). She gave birth to a healthy 3326‚?�g male infant at 40‚??weeks and 1‚??day gestation after natural onset of labor. After delivery, the serum complement components were analyzed. C9 protein and activity were undetectable in the patient's serum. We suggest that an immunologic disorde...

CLINDAMYCIN HYDROCHLORIDEcapsule [Physicians Total Care, Inc.]

Updated Date: Feb 16, 2012 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

EVOCLIN (Clindamycin Phosphate) Aerosol, Foam [Stiefel Laboratories Inc]

Updated Date: Feb 14, 2012 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

Management of a child with suspected acute septic arthritis

Acute septic arthritis of childhood is a potentially devastating disease that causes permanent disability and can result in death. Traditional treatment consists of a prolonged course of intravenous antibiotics combined with aggressive surgery. However, this approach is challenged by trials showing satisfactory outcomes with shorter treatment and less invasive surgery. Diagnostic arthrocentesis alone and an antibiotic for a fortnight, including initial intravenous administration for 2&ndash;4 days, suffice in most non-neonatal cases. A good penetrating agent, such as clindamycin or a first-generation cephalosporin, exceptionally high doses, and administration four times a day are probably key factors. If the symptoms and signs subside within a few days, and the serum C-reactive protein lev...<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>

Comparison of BD Phoenix and bioM√©rieux Vitek 2 automated systems for the detection of macrolide‚??lincosamide‚??streptogramin B resistance among clinical isolates of Staphylococcus

Abstract: Two automated systems, BD Phoenix and bioMérieux Vitek 2, were compared to a double-disk diffusion method for the detection of inducible resistance to clindamycin in Staphylococcus spp. Analysis of 524 clinical isolates revealed sensitivity and specificity of 100% and 99.6%, respectively, for Phoenix and 91.1% and 99.8%, respectively, for Vitek 2. (Source: Diagnostic Microbiology and Infectious Disease)

Probable Warfarin and Dapsone Interaction

We describe a case of a 41-year-old woman who was stable for over a year on 22.5 mg/week of warfarin. At a follow-up visit, her international normalized ratio (INR) was found to be supratherapeutic at 3.9. Her only significant change was acyclovir initiation for shingles, and clindamycin and dapsone for infection on her right foot. An interaction report was run using Micromedex with no interactions reported. Sixteen percent of the weekly dose was held and maintenance dose was continued. Two weeks later, the INR remained supratherapeutic at 4.3, with discontinuation of clindamycin and dapsone, 5 days earlier, as the only change. This time an interaction report was run using Lexi-Comp, which identified an interaction between warfarin and dapsone. The INR has been therapeutic and stable since...

Group B streptococcal carriage, serotype distribution and antibiotic susceptibilities in pregnant women at the time of delivery in a refugee population on the Thai - Myanmar border

Conclusions: GBS carriage is not uncommon in pregnant women living on the Thai-Myanmar border with a large range of serotypes represented. (Source: BMC Infectious Diseases)

CLINDAMYCIN HYDROCHLORIDEcapsule [Aurobindo Pharma Limited]

Updated Date: Feb 8, 2012 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

The Increased Risk of Community-Acquired Methicillin-Resistant Staphylococcus Aureus in Neck Infections in Young Children

Abstract&nbsp;&nbsp;An increase in the isolation rate of methicillin-resistant Staphylooccus aureus (MRSA) in pediatric deep space neck infections including abscesses has been noted in recent years. A recent study by Duggal et al. [9] analyzed the microbiology of deep neck space in children and identify the possible risk factors. Patients younger than 16&nbsp;months of age were 10 times more likely to have an S. aureus infection as compared to non S. aureus (P‚??&lt;‚??.0001). MRSA comprised the majority of all S. aureus isolates (58%). The majority of community acquired -MRSA (80%) and methicillin sensitive S. aureus isolates (83%) were identified in lateral abscesses in contrast to the non-S. aureus isolates that were located medially (56%). African American pediatric patients accounte...<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>

Valeant Pharmaceuticals Completes Divestiture Of Generic Dermatology Products To Mylan

Valeant Pharmaceuticals International, Inc. (NYSE: VRX and TSX: VRX) today announced that it has completed the divestiture of 1% clindamycin and 5% benzoyl peroxide gel (IDP-111), a generic version of Benzaclin, and 5% fluorouracil cream, (5-FU), an authorized generic of Efudex, to Mylan Inc. (Nasdaq: MYL). (Source: Pharmaceutical Online News)

Multidrug-Resistant, NAP2 Clostridium difficile was the Predominant Toxigenic, Hospital-Acquired Strain in the Province of Manitoba, Canada in 2006-2007.

The objective of the current study was to determine if the antimicrobial susceptibility profile or genotype of hospital-acquired isolates of Clostridium difficile differed from isolates causing community-acquired disease. Five hundred diarrheal stool samples (&gt;2 ml, one sample per patient) from patients across Manitoba, Canada in 2006-2007 that were reported as C. difficile toxin-positive were cultured and resulted in 432 isolates of toxin-positive C. difficile for analysis. Of the 432 isolates, acquisition status could be determined for 235 (54.4%) isolates; 182 (77.4%) were hospital-acquired and 53 (22.6%) were community-acquired. North American Pulsotype (NAP) designations based on SmaI pulsed-field gel electrophoresis could be defined for 52% of the 432 isolates with NAP2 (n = 122) ...

CLINDA-DERM (Clindamycin Phosphate) Solution [Paddock Laboratoratories, LLC]

Updated Date: Feb 1, 2012 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

Acute dacryocystitis in a 2-year old child caused by pantoea.

Authors: Zuberbuhler B, Carifi G, Leatherbarrow B Abstract A previously healthy 23-month-old girl was admitted for the management of an acute unilateral dacryocystitis following accidental contact with dog faeces. No periocular trauma was reported. Microbiological investigation showed a multiresistant strain of Pantoea species to be the responsible pathogen. The infection responded to a course of oral Clindamycin and Ciprofloxacin, in combination with Chloramphenicol eye drops. This is the first report of an acute dacryocystitis sustained by this microorganism. PMID: 22296230 [PubMed - in process] (Source: Orbit)

[Antibiotic-impregnated catheters. A useful tool against infection].

Authors: Gutiérrez-González R Abstract Progress in the treatment of hydrocephalus and particularly of cerebrospinal fluid (CSF) diversion surgery has been continuous and significant from cranial bandaging, which was one of the initial hydrocephalus treatments in the 16th century, to last-generation CSF shunts. However, infection currently remains the most frequent and serious complication despite the efforts made to prevent it. One of these current prevention measures is the use of antibiotic-impregnated catheters. A retrospective cohort study including shunts and external ventricular drains was designed to assess their efficacy in our scenario. The results show that rifampicin- and clindamycin-impregnated catheters are a helpful tool against CSF shunt-derived infection. PMID...<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>

Pneumocystis jiroveci pneumonia in patients with systemic lupus erythematosus after rituximab therapy.

We report PCP in two patients with SLE after rituximab treatment. Fever and respiratory symptoms associated with diffuse pulmonary infiltrates developed within weeks after rituximab therapy. One patient died of respiratory failure. Another patient recovered uneventfully after treatment with clindamycin and primaquine. PMID: 22287506 [PubMed - as supplied by publisher] (Source: Lupus)

Bath salts and necrotizing fasciitis: a case report

3 out of 5 stars Life-threatening Necrotizing Fasciitis Due to &#8216;Bath Salts&#8217; Injection. Russo R et al. Orthopedics¬ 2012 Jan 16;35(1):e124-7. doi: 10.3928/01477447-20111122-36. Abstract This dramatic case report fro Louisiana State University Health Sciences Center describes a 34-year-old woman who developed a rapidly progressing necrotizing fasciitis several days after injecting a &#8220;bath salt&#8221; product intramuscularly into the right forearm. The authors report that the infection was so virulent that: &#8220;In the time it took to expose the anterior upper arm, muscle in the forearm that had previously been contractile and pink had turned dusky and noncontractile.&#8221; In the effort to debride necrotic tissue and establish clean margins, the surgeons performed a fore...

Antimicrobial Resistance in Campylobacter spp. Isolated from Ontario Sheep Flocks and Associations between Antimicrobial use and Antimicrobial Resistance

The objectives of this study were to determine the prevalence of antimicrobial resistance (AMR) in faecal Campylobacter spp. from lambs and adult sheep and associations between antimicrobial use (AMU) and AMR. A total of 275 faecal samples collected during initial and final visits from 51 sheep flocks, including one feedlot, across southern Ontario were tested for the presence of Campylobacter spp. Campylobacter jejuni was detected in 52% (143/275) of the faecal samples, Campylobacter coli in 7% (19/275), Campylobacter lari in 1% (2/275) and 2% (4/275) were non‚?�speciated Campylobacter. Broth microdilution was used to test antimicrobial susceptibility of 162 isolates to nine antimicrobials. Campylobacter jejuni isolates (n‚??=‚??142) were resistant to tetracycline (39%), ciprofloxacin (4%...

Antimalarials/clindamycin/dexamethasone: Zygomycosis (first report with dapsone, pyrimethamine and clindamycin) and pancytopenia: case report

(Source: Reactions)<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>

Clindamycin: Clostridium difficile pancolitis in a child, treated with mesalazine: case report

(Source: Reactions)

Inhibition of Propionibacterium acnes lipase by extracts of Indian medicinal plants

This study reports for the first time the novel antilipase activity of chebulagic acid (IC50: 60 őľM) with MIC value of 12.5 őľg mL‚??1 against P. acnes.The inhibitory potential of plant extracts was further confirmed by plate assay. The organism was grown in the presence of subinhibitory concentrations of extracts from P. kurroa, V. negundo, T. chebula, E. ribes and antibiotics such as clindamycin and tetracycline. Extract from T. chebula showed significant inhibition of lipase activity and number of P. acnes.¬© 2012 The Authors ICS ¬© 2012 Society of Cosmetic Scientists and the Soci√©t√© Fran√ßaise de Cosm√©tologie (Source: International Journal of Cosmetic Science)

Effect of Peritoneal Lavage with Clindamycin-Gentamicin Solution on Infections after Elective Colorectal Cancer Surgery

Conclusions: Antibiotic lavage of the peritoneum is associated with a lower incidence of intra-abdominal abscesses and wound infections. (Source: Journal of the American College of Surgeons)

Single Dose of Antibiotic Leaves Mice Highly Vulnerable to Intestinal Infection

Yet another study adds to the growing evidence that antibiotics can disrupt the balance of the intestinal flora, with negative effects on health. A team of researchers from the Memorial Sloan Kettering Cancer Center, New York City, has shown in mouse models that a single dose of the commonly used antibiotic, clindamycin, wiped out nearly 90 percent of bacterial taxa, leaving the mice unusually susceptible to infection by¬ Clostridium difficile. Read more... (Source: American Society for Microbiology)

DUAC (Clindamycin Phosphate And Benzoyl Peroxide) Gel [Stiefel Laboratories Inc]

Updated Date: Jan 19, 2012 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>

CLINDAMYCIN HYDROCHLORIDEcapsule [Lannett Company, Inc.]

Updated Date: Jan 18, 2012 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

The Role of Rifampin against Propionibacterium acnes Biofilm in vitro and in an Experimental Foreign-Body Infection Model.

Authors: Furustrand Tafin U, Corvec S, Betrisey B, Zimmerli W, Trampuz A Abstract Propionibacterium acnes is an important cause of orthopedic implant-associated infections, for which the optimal treatment has not yet been determined. We investigated the activity of rifampin, alone and in combination, against planktonic and biofilm P. acnes in vitro and in a foreign-body infection model. The MIC and the minimal bactericidal concentration (MBC) were 0.007 and 4 őľg/ml for rifampin, 1 and 4 őľg/ml for daptomycin, 1 and 8 őľg/ml for vancomycin, 1 and 2 őľg/ml for levofloxacin, 0.03 and 16 őľg/ml for penicillin G, 0.125 and 512 őľg/ml for clindamycin, and 0.25 and 32 őľg/ml for ceftriaxone, respectively. The P. acnes minimal biofilm eradication concentration (MBEC) was 16 őľg/ml for rif...

Pharmacokinetics of Clindamycin in the Plasma and Dialysate after Intraperitoneal Administration of Clindamycin Phosphoester to Patients on Continuous Ambulatory Peritoneal Dialysis: An Open‚?�Label, Prospective, Single‚?�Dose, Two‚?�Institution Study

Abstract:‚?? We evaluated the pharmacokinetics of clindamycin and the dose of clindamycin phosphate necessary to treat peritonitis after intraperitoneal administration of clindamycin phosphate to patients on continuous ambulatory peritoneal dialysis (CAPD). This was an open‚?�label, prospective, single‚?�dose study conducted at the two levels of institutional clinical care in South Korea. Twelve patients (six men and six women; all older than 25‚??years), mean CAPD duration of 38.2‚??months with various origins without peritonitis, received 600‚??mg clindamycin phosphate mixed with only the first 2‚?�L dialysate (1.5% dextrose). The 1.5%, 1.5%, 2.5% and 1.5% dextrose dialysates were serially exchanged every 6‚??hr. If patients were non‚?�anuric, 24‚?�hr urine samples were also collected. C...

Comparison of the Effects of Human ő≤-defensin 3, Vancomycin, and Clindamycin on Staphylococcus aureus Biofilm Formation.

Authors: Huang Q, Yu HJ, Liu GD, Huang XK, Zhang LY, Zhou YG, Chen JY, Lin F, Wang Y, Fei J Abstract Despite improvements in surgical techniques and implant design in orthopedic surgery, implantation-associated infections are still a challenging problem for surgeons. In 2006, trace quantities of human ő≤-defensin 3 (hBD-3) were found in human bone tissue and bone cells. Human ő≤-defensin 3 is a 45-amino-acid peptide that is considered the most promising class of defensin antimicrobial peptides and may help in the prevention and treatment of implantation-associated infections. Studies of the effectiveness of hBD-3 against Staphylococcus aureus showed that hBD-3 was more potent at low concentrations than other antibiotics. The effect of hBD-3 on S aureus biofilms has not been reporte...

Prevalence, characterization and antimicrobial resistance of Listeria monocytogenes isolated from bovine hides and carcasses.

Authors: Wieczorek K, Dmowska K, Osek J Abstract L. monocytogenes isolated from bovine hides and carcasses (n = 812) were mainly of serogroup 1/2a. All strains were positive for internalin genes. Several isolates (72.2%) were resistant to oxacillin or clindamycin (37.0%). These findings indicate that L. monocytogenes of beef origin can be considered as a public health concern. PMID: 22247138 [PubMed - as supplied by publisher] (Source: Applied and Environmental Microbiology)<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>

CLINDAMYCIN HYDROCHLORIDEcapsule [Ranbaxy Pharmaceuticals Inc.]

Updated Date: Jan 12, 2012 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

Group B Streptococcus infections in non-pregnant adults: the role of immunosuppression

Conclusions: GBS, previously considered a genitourinary pathogen, has emerged as a non-nosocomial opportunistic pathogen causing BSI, endocarditis, and CNS infections. Immunosuppression, particularly transient immunosuppressed states, was an independent predictor for GBS BSI. Resistance rates to macrolides and clindamycin continue to increase, and should be closely monitored. (Source: International Journal of Infectious Diseases)

Susceptibility trends of Bacteroides fragilis group and characterisation of carbapenemase-producing strains by automated REP-PCR and MALDI TOF.

Authors: Trevi√~+mn~o M, Areses P, Dolores Pe√~+mn~alver M, Cortizo S, Pardo F, Luisa P√©rez Del Molino M, Garc√≠a-Riestra C, Hern√°ndez M, Llovo J, Regueiro BJ Abstract Susceptibility testing of clinical isolates of anaerobic bacteria is not considered, often, mandatory in routine clinical practice and the treatments are empirically established. Thus, periodic monitoring of the susceptibility patterns of anaerobic bacteria is advisable. The aim of this study was to update on resistance of Bacteroides fragilis group in our Institution with special attention to carbapenems reporting metallo-beta-lactamase producing strains for the first time in Spain, and to compare fingerprinting analysis results obtained by using automated rep-PCR (DiversiLab System) and MALDI-TOF MS. A total of 830 non-d...

First National Survey of Antibiotic Susceptibility of the Bacteroides fragilis Group: Emerging Resistance to Carbapenems in Argentina.

Authors: Fern√°ndez-Canigia L, Litterio M, Legaria MC, Castello L, Predari SC, Di Martino A, Rossetti A, Rollet R, Carloni G, Bianchini H, Cejas D, Radice M, Gutkind G, Abstract The susceptibility rates of 363 clinical Bacteroides fragilis group isolates collected from 17 centers in Argentina during the period 2006-2009 were as follows: piperacillin-tazobactam 99 %, ampicillin-sulbactam 92 %, cefoxitin 72 %, tigecycline 100 %, moxifloxacin 91 %, clindamycin 52 %, and no metronidazole resistance was detected. Resistance to imipenem, doripenem and ertapenem was observed in 1.1 %, 1.6 % and 2.3 % of B. fragilis group strains, respectively. B. fragilis species showed a resistance profile of 1.5 % to imipenem, 1.9 % to doripenem and 2.4 % to ertapenem, being the first report of carbape...

Evaluation of MBEC‚?Ę‚?�HTP biofilm model for studies of implant associated infections

In this study we evaluated the Minimum Biofilm Eradication Concentration‚?�High Throughput Plates (MBEC‚?Ę‚?�HTP) as biofilm in vitro model for studies of implant associated infections. Staphylococcus aureus and Staphylococcus epidermidis biofilms were grown on MBEC‚?Ę‚?�HTP. To ensure the biofilm formation, antibiotic susceptibility tests and scanning electron microscopy (SEM) was carried out. Susceptibility tests were carried out using gentamicin, vancomycin, rifampicin, fosfomycin, clindamycin, and linezolid. Colony forming units counting were carried out. Minimal inhibitory concentration (MIC) and biofilm inhibitory concentration (BIC) were estimated. The CFU counting showed potency of rifampicin and daptomycin against S. epidermidis biofilms and rifampicin against S. aureus biofilms. ...<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>

CLINDAMYCIN HYDROCHLORIDEcapsule [Lake Erie Medical DBA Quality Care Products LLC]

Updated Date: Jan 5, 2012 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

Consider Antibiotics, Laser Surgery for Hidradenitis SuppurativaConsider Antibiotics, Laser Surgery for Hidradenitis Suppurativa

Clindamycin with either carbon dioxide or Nd:YAG laser treatments should be considered first-line therapies for mild-to-moderate hidradenitis suppurativa. Reuters Health Information (Source: Medscape Dermatology Headlines)

Clindamycin plus quinine for treating uncomplicated falciparum malaria: a systematic review and meta-analysis

The evidence on the efficacy of clindamycin plus quinine as an alternative treatment for uncomplicated malaria is inconclusive. Adequately powered trials are urgently required to compare this combination with artemisinin-based combinations. (Source: Malaria Journal)

Phenotypes and genotypes of erythromycin-resistant Streptococcus pyogenes strains isolated from invasive and non-invasive infections from Mexico and the USA during 1999‚??2010

Conclusions: Erythromycin resistance continues to exist at low levels in both Mexico and the USA, although the genetic mechanisms responsible differ between the two nations. These genetic differences may be related to the invasive character of the S. pyogenes isolated. (Source: International Journal of Infectious Diseases)<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>

Delayed-onset infections after impacted lower third molar extraction: involved bacteria and sensitivity profiles to commonly used antibiotics

Conclusions: Fusobacterium sp., Prevotella sp., and Peptostreptococcus sp. are frequently present in delayed-onset infections after lower third molar removal. Based on the results of the microbial susceptibility tests, clindamycin seems to be the most adequate antibiotic for the treatment of this complication. (Source: Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontics)

Consider antibiotics, laser surgery for hidradenitis suppurativa, review suggests

NEW YORK (Reuters Health) - Clindamycin with either carbon dioxide or Nd:YAG laser treatments should be considered first-line therapies for mild-to-moderate hidradenitis suppurativa (HS), according to a new review of treatments for the rare disease. (Source: Modern Medicine)

Cochrane Review: Different antibiotic treatments for group A streptococcal pharyngitis

AbstractBackgroundAntibiotics provide only modest benefit in treating sore throat, although effectiveness increases in participants with positive throat swabs for group A beta‚?�haemolytic streptococci (GABHS). It is unclear which antibiotic is the best choice if antibiotics are indicated.ObjectivesWe assessed the comparative efficacy of different antibiotics on clinical outcomes, relapse, complications and adverse events in GABHS tonsillopharyngitis.Search methodsWe searched The Cochrane Library, Cochrane Central Register of Controlled Trials (CENTRAL 2010, Issue 3) which includes the Acute Respiratory Infections Group's Specialised Register, MEDLINE (1966 to July Week 4, 2010) and EMBASE (1974 to August 2010).Selection criteriaRandomised, double‚?�blind trials comparing different antibio...

Comparative Effectiveness of Antibiotic Treatment Strategies for Pediatric Skin and Soft-tissue Infections: Williams DJ, Cooper WO, Kaltenbach LA, et al. Pediatrics 2011;128:479‚??87.

This was a retrospective cohort study of 47,501 children aged 0‚??17 years comparing the effectiveness of treatment with trimethoprim-sulfamethoxazole (TMP-SMX) or a ő≤-lactam vs. clindamycin in drained and undrained skin and soft-tissue infections (SSTI). Children with an SSTI and prescription for either clindamycin (reference treatment), trimethoprim-sulfamethoxazole, or a ő≤-lactam (penicillin or cephalosporin) filled within 2 days of the SSTI were included in the study and grouped based on drainage status. Exclusion criteria included: SSTI within the last 365 days, treatment with multiple agents, treatment with topical antibiotics, SSTI requiring hospital admission, burns, foreign bodies, or surgical-site infections. Effectiveness of each antibiotic therapy was defined with respect to ...

BENZACLIN (Clindamycin Phosphate And Benzoyl Peroxide) Gel [Physicians Total Care, Inc.]

Updated Date: Dec 28, 2011 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>

CLINDAMYCIN HYDROCHLORIDEcapsule [American Health Packaging]

Updated Date: Dec 27, 2011 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

Prevalence of Antimicrobial Resistance among Clinical Isolates of Bacteroides fragilis group in Canada in 2010-2011: CANWARD Surveillance Study.

Authors: Karlowsky JA, Walkty AJ, Adam HJ, Baxter MR, Hoban DJ, Zhanel GG Abstract Clinical isolates of Bacteroides fragilis group (n = 387) were collected from patients attending nine Canadian hospitals in 2010-2011 and tested for susceptibility to 10 antimicrobial agents using the Clinical and Laboratory Standards Institute (CLSI) broth microdilution method. B. fragilis (59.9%), Bacteroides ovatus (16.3%), and Bacteroides thetaiotamicron (12.7%) accounted for ‚?ľ90% of isolates collected. Overall rates of percent susceptibility were: 99.7%, metronidazole; 99.5%, piperacillin-tazobactam; 99.2% imipenem; 97.7%, ertapenem; 92.0%, doripenem; 87.3%, amoxicillin-clavulanate; 80.9%, tigecycline; 65.9%, cefoxitin; 55.6%, moxifloxacin; and 52.2%, clindamycin. Percent susceptibility to cef...

A Comparison of Dequalinium Chloride Vaginal Tablets (Fluomizin¬ģ) and Clindamycin Vaginal Cream in the Treatment of Bacterial Vaginosis: A Single-Blind, Randomized Clinical Trial of Efficacy and Safety

(Source: Gynecologic and Obstetric Investigation)

Microbiology of regressive autism.

Authors: Finegold SM, Downes J, Summanen PH Abstract This manuscript summarizes some of our earlier work on the microbiology of autism subjects' stool specimens, as compared with stools from control subjects. Our most recent data indicating that Desulfovibrio may play an important role in regressive autism is also presented. In addition, we present information on antimicrobial susceptibility patterns of Desulfovibrio using the CLSI agar dilution susceptibility technique. In addition, we summarize data from our earlier studies showing the impact of various antimicrobial agents on the indigenous bowel flora. This shows that penicillins and cephalosporins, as well as clindamycin, have a major impact on the normal bowel flora and therefore might well predispose subjects to overgrowth o...

CLINDAMYCIN HYDROCHLORIDEcapsule [PD-Rx Pharmaceuticals, Inc.]

Updated Date: Dec 20, 2011 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>

A Systematic Review of Treatments for Hidradenitis Suppurativa [Study]

Conclusions&nbsp; Shown to be effective treatments for HS were a clindamycin-rifampin combination regimen, a course of infliximab, monthly Nd:YAG laser sessions, and surgical excision and primary closure with a gentamicin sulfate&ndash;collagen sponge. Most therapies used to treat HS were supported by limited or weak scientific evidence. A treatment approach is presented based on the evidence and on clinical experience at the Follicular Disorders Clinic, Department of Dermatology, Henry Ford Hospital, Detroit, Michigan. This review emphasizes the need for large randomized controlled trials to evaluate treatment options for HS. (Source: Archives of Dermatology)

Methicillin-Resistant Staphylococcus aureus Colonization in Otitis-Prone Children [Original Article]

Conclusions&nbsp; The prevalence of MRSA colonization among otitis-prone children was similar to rates reported among the general pediatric community. Methicillin-resistant S aureus colonization at the time of bilateral myringotomy and tube insertion was not predictive of subsequent otorrhea. (Source: Archives of Otolaryngology)

Methicillin-Resistant Staphylococcus aureus Ocular Infection: A 10-Year Hospital-Based Study

Conclusions: Community-associated MRSA is an important pathogen of ocular infections; CA-MRSA and HA-MRSA ocular infections differ demographically and clinically, but both strains were multi-resistant in Chang Gung Memorial Hospital, one of the biggest referral centers in Taiwan. In a country with a high prevalence of MRSA, ophthalmologists should be aware of such epidemiologic information. Financial Disclosure(s): The author(s) have no proprietary or commercial interest in any materials discussed in this article. (Source: Ophthalmology)

BENZACLIN (Clindamycin Phosphate And Benzoyl Peroxide) Gel [Dermik Laboratories]

Updated Date: Dec 15, 2011 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

First Report of Methicillin-Resistant Staphylococcus aureus ST5 and ST398 from Purebred Lusitano Horses

Abstract: Methicillin-resistant Staphylococcus aureus (MRSA) was first described in horses in 1996. The frequency of MRSA colonization in horses varies among European countries, but it is unknown in Portugal. The aim of this study was to screen for MRSA nasal carriage in a sample of horses entering the Equine Unit, Large Animal Veterinary Teaching Hospital of the Faculty of Veterinary Medicine, Lisbon, Portugal. Seventy-one horses were swabbed, and MRSA was identified by selective isolation on a chromogenic medium. Two S aureus isolates showed resistance to oxacillin (minimum inhibitory concentration >4¬ őľg/mL) and contained the mecA gene. Both strains were isolated from purebred Lusitano horses that lived in farms with more than 20 equines. These MRSA strains represented two different cl...<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>

ICEPmu1, an integrative conjugative element (ICE) of Pasteurella multocida: analysis of the regions that comprise 12 antimicrobial resistance genes

Conclusions The observation that 12 resistance genes, organized in two resistance gene regions, represent part of an ICE in P. multocida underlines the risk of simultaneous acquisition of multiple resistance genes via a single horizontal gene transfer event. (Source: Journal of Antimicrobial Chemotherapy)