Can interchangeability of lincosamides be assumed in clinical practice? Comparative MICs of clindamycin and lincomycin for Streptococcus pyogenes, Streptococcus agalactiae and Staphylococcus aureus

(Source: Journal of Antimicrobial Chemotherapy)

Relationship Between the Severity of Acne Vulgaris and Antimicrobial Resistance of Bacteria Isolated from Acne Lesions in a Hospital of Japan.

Authors: Nakase K, Nakaminami H, Takenaka Y, Hayashi N, Kawashima M, Noguchi N Abstract Propionibacterium acnes and Staphylococcus epidermidis are normal skin inhabitants that are frequently isolated from lesions caused by acne, and these microorganisms are considered to contribute to the inflammation of acne. In the present study, we examined the antimicrobial susceptibilities and resistance mechanisms of P. acnes and S. epidermidis that were isolated from patients with acne vulgaris in a university hospital in Japan from 2009 to 2010. Additionally, we analysed the relationship between the antimicrobial resistance of P. acnes and the severity of acne vulgaris. Some P. acnes strains (18.8% (13/69)) were resistant to clindamycin. All strains had a mutation in the 23S rRNA gene, exce...

Is Clostridium difficile associated with the ‚??4C‚?? antibiotics? A retrospective observational study in diabetic foot ulcer patients

ConclusionsLarge doses, numbers and greater duration of antibiotic therapy all result in a greater degree of normal gut flora depletion. It is possible that the alterations in gut flora in diabetic foot ulcer patients protect them from antibiotic‚?źinduced C. difficile overgrowth. (Source: International Journal of Clinical Practice)

CLINDAMYCIN PHOSPHATE Cream [Greenstone LLC]

Updated Date: Jan 28, 2014 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

The application of quantitative NMR for the facile, rapid and reliable determination of clindamycin phosphate in a conventional tablet formulation.

Authors: Liang X, Du L, Su F, Parekh HS, Su W Abstract Spectroscopic tools such as NMR can be applied to the quantitative analysis of active pharmaceutical ingredients with relative ease and accuracy. Here, we demonstrate the quantification of clindamycin phosphate (CLP) in a conventional tablet formulation, performed using potassium hydrogen phthalate (KHP) as the internal standard and deuterium oxide (D2 O) as the NMR solvent. The methyl protons signal of CLP at 0.72‚??ppm (triplet) relative to the signal of KHP at 7.37-7.40‚??ppm (multiplet) was used for quantification purposes using (1) H NMR. This method was shown to be specific and linear (r‚??=‚??0.9997) within the CLP concentration range from 7.2 to 23.1‚??mg per 0.5‚??ml of D2 O. The maximum relative standard deviation (RS...<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>

CLINDAMYCIN HYDROCHLORIDE Capsule [Greenstone LLC]

Updated Date: Jan 24, 2014 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

CLINDAMYCIN PHOSPHATE Solution CLINDAMYCIN PHOSPHATE Lotion CLINDAMYCIN PHOSPHATE Gel [Greenstone LLC]

Updated Date: Jan 24, 2014 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

Prevalence, Serotype Identification by Multiplex Polymerase Chain Reaction and Antimicrobial Resistance Patterns of Listeria Monocytogenes Isolated from Retail Foods

This study focused on the prevalence of L.‚??monocytogenes in different raw and ready‚?źto‚?źeat foodstuffs, and serotype distribution among the isolates. Antibiotic resistance profiles of the isolates were also reported. Information and relief provided to consumers could help elaborate public health and food safety. (Source: Journal of Food Safety)

Mandibular Fracture-Induced Osteoradionecrosis

Osteoradionecrosis is the collateral effect of radiotherapy in the head and neck and is of great clinical significance. A case of mandibular fracture-induced osteoradionecrosis was reported. Man, 52, sought dental care with a history of oral cancer and radiotherapy. Examination revealed extraoral fistula in the left jaw, limited mouth opening, and an area of intraoral exposed bone. The clinical diagnosis was osteoradionecrosis. The panoramic radiograph revealed fracture of the left mandibular body. Clindamycin plus daily mouthwash with chlorhexidine gluconate 0.12% for 15 days was prescribed, resulting in the closure of intraoral and extraoral fistulae. The mandibular fracture remains, with the patient awaiting further intervention. We highlight the importance of integration between medi...

Radiography-based score indicative for the pathogenicity of bacteria in odontogenic infections.

Conclusions. The radiography-based score suggests that certain Prevotella spp., F. nucleatum and Strep. anginosus groups play a crucial role in the pathogenesis of odontogenic abscesses, and that various streptococci, Neisseria spp., Capnocytophaga spp., Staph. aureus and Prevotella spp. are involved in the pathogenesis of odontogenic infiltrates. PMID: 24444257 [PubMed - as supplied by publisher] (Source: Acta Odontologica Scandinavica)<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>

CLINDAMED (Clindamycin) Liquid [Bimeda, Inc., Division Of Cross Vetpharm Group]

Updated Date: Jan 17, 2014 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

Antimicrobial susceptibility of Ureaplasma urealyticum and Mycoplasma hominis

This study was conducted at the Department for Urogenital Infections and Sexually Transmitted Diseases, University Hospital for Infectious Diseases &lsquo;Dr Fran Mihaljevic&rsquo; Zagreb, Croatia, during the years 2010 and 2011. The study included a total of 544 positive isolates with &ge;104 CCU (Colour Changing Units) detected in female or male patients older than 18&nbsp;years. There were a total of 37 specimens positive for M hominis, and 507 positive... (Source: Sexually Transmitted Infections)

Acute localised exanthematous pustulosis (ALEP) induced by clindamycin in pregnancy

We describe a case of ALEP triggered by oral clindamycin that occurred during pregnancy. (Source: Australasian Journal of Dermatology)

CLINDAMYCIN HYDROCHLORIDE Capsule [American Health Packaging]

Updated Date: Jan 14, 2014 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

Acute localised exanthematous pustulosis (ALEP) induced by clindamycin in pregnancy.

We describe a case of ALEP triggered by oral clindamycin that occurred during pregnancy. PMID: 24417617 [PubMed - as supplied by publisher] (Source: The Australasian Journal of Dermatology)<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>

Successful treatment of simulated Clostridium difficile infection in a human gut model by fidaxomicin first line and after vancomycin or metronidazole failure

Conclusions Fidaxomicin successfully treated simulated primary and recurrent CDI. Fidaxomicin was superior to metronidazole in reducing CD TVC and SP, and superior to vancomycin in reducing SP without recurrence of vegetative cell growth. Fidaxomicin, but not vancomycin or metronidazole, persisted in the gut model for &gt;20 days after instillation. (Source: Journal of Antimicrobial Chemotherapy)

In vivo efficacy of ceftaroline fosamil in a methicillin-resistant pvl-producing staphylococcus aureus rabbit pneumonia model.

Conclusions: Ceftaroline fosamil, clindamycin, and to a lesser extent linezolid, were efficient in reducing bacterial titers in both the lungs and spleen and decreasing macroscopic score and PVL production compared with control. PMID: 24395236 [PubMed - as supplied by publisher] (Source: Antimicrobial Agents and Chemotherapy)

Prevalence of inducible clindamycin resistance among community-associated staphylococcal isolates in central Serbia

AD Aleksandra, MS Misic, ZV Mira, NM Violeta, IT Dragana, BM Zoran, VS Dejan, SD Milanko, BD DejanIndian Journal of Medical Microbiology 2014 32(1):49-52The emergence of resistance to most antimicrobial agents in staphylococci indicates the need for new effective agents in the treatment of staphylococcal infections. Clindamycin is considered to be one safe, effective and less costly agent. We analysed 482 staphylococcal isolates. Detection of inducible clindamycin resistance was performed by the D-test, while the presence of methylases genes: erm (A), erm (B) and erm (C), as well as, macrolide efflux gene mef was determined by polymerase chain reaction. Inducible clindamycin resistance phenotype was significantly higher in Staphylococcus aureus (S. aureus) strains then in coagulase-negativ...

CLINDAMYCIN HYDROCHLORIDE Capsule [Aidarex Pharmaceuticals LLC]

Updated Date: Jan 2, 2014 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

Rhabdomyolysis as a manifestation of clomipramine poisoning.

CONCLUSIONS: Although arrhythmia is the most important complication, rhabdomyolysis should be investigated in cases of clomipramine poisoning. PMID: 24346784 [PubMed - in process] (Source: Sao Paulo Medical Journal)<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>

Commensal Streptococcus agalactiae isolated from patients seen at University Hospital of Londrina, Parana, Brazil: capsular types, genotyping, antimicrobial susceptibility and virulence determinants

Conclusions: Our results indicate the potential virulence of commensal GBS isolates, reinforcing the need for continued screening for this bacterium to prevent infections. The distribution of capsular and pili antigens, and MLVA profiles was also identified, which may contribute to the development of new strategies for the prevention and treatment of GBS infection. (Source: BMC Microbiology - Latest articles)

Commensal Streptococcus agalactiae isolated from patients seen at University Hospital of Londrina, Paran√°, Brazil: capsular types, genotyping, antimicrobial susceptibility and virulence determinants

Conclusions: Our results indicate the potential virulence of commensal GBS isolates, reinforcing the need for continued screening for this bacterium to prevent infections. The distribution of capsular and pili antigens, and MLVA profiles was also identified, which may contribute to the development of new strategies for the prevention and treatment of GBS infection. (Source: BMC Microbiology - Latest articles)

The effect of high dose antibiotic impregnated cement on rate of surgical site infection after hip hemiarthroplasty for fractured neck of femur: a protocol for a double-blind quasi randomised controlled trial

DiscussionLarge randomised controlled trials assessing the effectiveness of a surgical intervention are uncommon, particularly in the speciality of orthopaedics. The results from this trial will inform evidence-based recommendations for antibiotic impregnated cement in the management of patients with a fractured neck of femur undergoing a hip hemiarthroplasty. If high dose antibiotic impregnated cement is found to be an effective intervention, implementation into clinical practice could improve long-term outcomes for patients undergoing hip hemiarthroplasty.Trial registration: Current Controlled Trials: ISRCTN25633145 (Source: BioMed Central)

CLINDAGEL (Clindamycin Phosphate) Gel [Galderma Laboratories, L.P.]

Updated Date: Dec 17, 2013 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

Trends in Antibiotic Resistance in Coagulase Negative Staphylococci, United States, 1999--2012.

Authors: May L, Klein EY, Rothman RE, Laxminarayan R Abstract Coagulase-negative staphylococci (CoNS) are important bloodstream pathogens typically resistant to multiple antibiotics. Despite concern about increasing resistance, there have been no recent studies describing the national prevalence in CoNS pathogens. We used national resistance data over a period of 13 years (1999-2012) from The Surveillance Network (TSN) to determine prevalence and assess trends in resistance for S. epidermidis, the most common CoNS pathogen, as well as all CoNS pathogens. Over the course of the study period, S. epidermidis resistance to ciprofloxacin and clindamycin increased steadily from 58.3% to 68.4% and from 43.4% to 48.5%, respectively. Resistance to levofloxacin increased rapidly from 57.1% i...<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>

Treatment of hidradenitis supprurativa associated pain with nonsteroidal anti-inflammatory drugs, acetaminophen, celecoxib, gabapentin, pegabalin, duloxetine, and venlafaxine.

Authors: Scheinfeld N Abstract Hidradenitis Supprurativa is a painful dermatological condition. Although the pain of HS has unique aspects, the pain of HS pain shares common elements with essential pain, fibromyalgia, and pure neuropathic pain syndromes. Futhermore, depression plays an important role in the pain of HS. This paper reviews the potential for use of nonsteroidal anti-inflammatory drug (NSAIDS), acetaminophen, celecoxib, gabpentin, pregabalin, and the serotonin and norepinephrine reuptake inhibitors (SNRIs), duloxetine and venlafaxine, for treating HS related pain. No studies exist for pain control in HS. Initially, the pain of HS is treated medically e.g. oral rifampin and clindamycin or adalimumab to decrease inflammation, but an analysis of pain medications to treat ...

Fourth Belgian multicentre survey of antibiotic susceptibility of anaerobic bacteria

Conclusions Compared with previous surveys, little evolution was seen in susceptibility, except a decline in activity of clindamycin against Prevotella spp. and other Gram-negative bacteria, and of moxifloxacin against clostridia. Since resistance was detected to all antibiotics, susceptibility testing of anaerobic isolates is indicated in severe infections to confirm appropriateness of antimicrobial therapy. (Source: Journal of Antimicrobial Chemotherapy)

Molecular analysis and distribution of multidrug-resistant Enterococcus faecium isolates belonging to clonal complex 17 in a tertiary care center in Mexico City

Conclusion: This study provides the first report of multidrug-resistant VREF isolates belonging to clonal complex 17 from a tertiary care center in Mexico City. Multidrug resistance and genetic determinants of virulence confer advantages among VREF in the colonization of their host. Therefore, the prevention and control of the spread of nosocomial infections caused by VREF is crucial for identifying new emergent subclones that could be challenging to treat in subsequent years. (Source: BMC Microbiology - Latest articles)

Propionibacterium acnes: An Underestimated Pathogen in Implant-Associated Infections.

Authors: Portillo ME, Corvec S, Borens O, Trampuz A Abstract The role of Propionibacterium acnes in acne and in a wide range of inflammatory diseases is well established. However, P. acnes is also responsible for infections involving implants. Prolonged aerobic and anaerobic agar cultures for 14 days and broth cultures increase the detection rate. In this paper, we review the pathogenic role of P. acnes in implant-associated infections such as prosthetic joints, cardiac devices, breast implants, intraocular lenses, neurosurgical devices, and spine implants. The management of severe infections caused by P. acnes involves a combination of antimicrobial and surgical treatment (often removal of the device). Intravenous penicillin G and ceftriaxone are the first choice for serious infec...

Failure of Clindamycin to Eradicate Infection with Beta-Hemolytic Streptococci Inducibly Resistant to Clindamycin in an Animal Model and in Human Infections.

Conclusions:We have demonstrated in a murine model of infection and from human cases inducible clindamycin resistance in ő≤-hemolytic streptococci is clinically significant. Routine testing and reporting by clinical laboratories should be encouraged and alternative antimicrobial agents considered when these organisms are encountered in clinical care. PMID: 24323478 [PubMed - as supplied by publisher] (Source: Antimicrobial Agents and Chemotherapy)<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>

Determination of clindamycin and its metabolite clindamycin sulfoxide in diverse sewage samples.

Authors: Oertel R, Schubert S, M√ľhlbauer V, B√ľttner B, Marx C, Kirch W Abstract In a research project on risk management of harmful substances in water cycles, clindamycin and 12 further antibiotics were determined in different sewage samples. In contrast to other antibiotics, an increase of the clindamycin concentration in the final effluent in comparison to the influent of the sewage treatment plant (STP) was observed. A back transformation from the main metabolite clindamycin sulfoxide to clindamycin during the denitrification process has been discussed. Therefore, the concentration of this metabolite was measured additionally. Clindamycin sulfoxide was stable in the STP and the assumption of back transformation of the metabolite to clindamycin was confuted. To explain the inc...

Comparison of Sensititre microdilution method to other standard methods for susceptibility testing of coagulase-negative staphylococci from paediatric blood cultures

Abstract: Susceptibility testing on 60 isolates of Staphylococcus epidermidis and 20 isolates of Staphylococcus hominis was performed using the Sensititre (Trek Diagnostics, Cleveland, OH, USA) method and compared with Vitek-2 automated susceptibility testing (bioMèrieux, Marcy l'Etoile, France), MICE strips for minimum inhibitory concentration determination (Oxoid, Basingstoke, UK), and disc diffusion (MAST, Bootle, UK). The categorical agreement between Vitek and Sensititre was greater than 90% for agents tested against S. epidermidis except for tetracycline (52%) and oxacillin (67%), and for S. hominis, the agreement was greater than 90% except for tetracycline (80%), gentamicin (65%), and oxacillin (75%). The categorical agreement between disc diffusion and Sensititre was greater than...

[Toxoplasma uveitis in a patient with ankylosing spondylitis].

Authors: Deveci H, Kobak S Abstract In this paper, a posterior uveitis case was reported in a patient who was being followed and under treatment for Ankylosing Spondylitis. Toxoplasma antibodies were investigated and anti-toxoplasma IgG was positive. Systematic treatment (Sulfamethoxazole/Trimethoprim and Clindamycin) was started. Despite medical treatment, reduction in visual acuity and development of dense membranous condensation in vitreous occurred. Surgical vitrectomy was performed. When posterior uveitis develops in patients who undergo immunosuppressive treatment, toxoplasma is among the first infectious agents that we should consider. A delay in diagnosis and treatment may result in failure in obtaining the desired outcome from medical treatment and a shift to surgical trea...

Inspiration from Old Dyes: Tris(stilbene) Compounds as Potent Gram-Positive Antibacterial Agents.

Prevalence of antibiotic resistance in US hospitals

Abstract: The percentage of isolates resistant to essential antibiotics among clinically significant bacterial pathogens was evaluated using data from 80089 qualifying admissions in 19 US hospitals (2007‚??2010). Percentage resistant was highest for the following pathogen/antibiotic pairs: Enterococcus faecium/vancomycin (87.1% [95% CI 86.0‚??88.1] of 4024 isolates), Staphylococcus aureus/oxacillin‚??methicillin (56.8% [56.1‚??57.4] of 23477 isolates), S. aureus/clindamycin (39.7% [39.1‚??40.4] of 21133 isolates), Pseudomonas aeruginosa/fluoroquinolones (32.6% [31.8‚??33.5] of 10982 isolates), and Escherichia coli/fluoroquinolones (31.3% [30.8‚??31.8] of 30715 isolates). The percentage resistant was 3.9% (3.2‚??4.9) for E. faecium/daptomycin (n = 2029 isolates). While these results are con...<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>

Antibiotics for methicillin-resistant Staphylococcus aureus skin and soft tissue infections: the challenge of outpatient therapy

Conclusion: Methicillin-resistant Staphylococcus aureus is a particularly virulent, rapidly adaptive pathogen that is becoming increasingly difficult to combat with existing antibiotics. Care must be taken to ensure appropriate treatment and follow-up of patients with known MRSA infections. (Source: The American Journal of Emergency Medicine)

Antibiogram, adhesive characteristics, and incidence of class 1 integron in Aeromonas species isolated from two South african rivers.

Authors: Igbinosa IH, Chigor VN, Igbinosa EO, Obi LC, Okoh AI Abstract Aeromonas species are well distributed in freshwater environments, and their natural susceptibility to antimicrobials renders them interesting candidates for the survey of antimicrobial resistance in freshwater milieu. Water samples were collected from Kat and Tyume rivers in the Eastern Cape province of South Africa, and a total of 45 isolates identified as Aeromonas species were recovered from the two rivers. All Aeromonas isolates were resistant to oxacillin, penicillin, clindamycin, cephalothin, vancomycin, and rifamycin, while appreciable susceptibilities (89.3‚??:‚??94.1%, 82.1‚??:‚??94.1%, 85.7‚??:‚??88.2%, and 92.9‚??:‚??88.2%) were observed against ciprofloxacin, chloramphenicol, nitrofurantoin, and gen...

Community-associated Clostridium difficile infection among older people in Tayside, Scotland, is associated with antibiotic exposure and care home residence: cohort study with nested case-control

Conclusions Our results have two important implications. First, they validate the classification of 4C antibiotics and fluoroquinolones in primary care as high risk for CA-CDI. Second, they demonstrate the importance of prior antibiotic exposure and place of residence for risk assessment by primary care prescribers. (Source: Journal of Antimicrobial Chemotherapy)

Healthcare associated infections caused by coagulase-negative Staphylococci in a neonatal intensive care unit

CONCLUSION: Coagulase-negative Staphylococci was the main agent identified in healthcare-associated infections, with low rates of infections related to central venous catheter. In hospitals with a high oxacillin resistance profile, similar to those included in this study, vancomycin may be used as an initial therapy, although clindamycin represents a viable alternative. (Source: Revista Brasileira de Terapia Intensiva)

Corynebacterium diphtheriae and the Returned Tropical Traveler

ConclusionThe majority of C. diphtheriae isolated were from SSIs in otherwise healthy travelers returning from tropical destinations, rather than classical risk groups. Clinicians and laboratories need to be aware of this potential source of C. diphtheriae infection due to rare toxigenic strains. (Source: Journal of Travel Medicine)<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>

Molecular Epidemiological Characteristics of Streptococcus pyogenes Strains Involved in an Outbreak of Scarlet Fever in China, 2011.

CONCLUSION: Several highly diversified clones with a high macrolide resistance rate comprise a predominant proportion of circulating strains, though no new emm type was found in this outbreak. The data provide a baseline for further surveillance of scarlet fever, which may contribute to the explanation of the outbreak and development of a GAS vaccine in China. PMID: 24331532 [PubMed - in process] (Source: Biomedical and Environmental Sciences : BES)

Pityriasis folliculorum: A novel therapy for a diagnostically challenging condition

To the Editor: A 26-year-old Caucasian man with recalcitrant rosacea presented with a 2-year history of persistent facial flushing, stinging, pruritus, blepharitis, pustules, and a ‚??sandpaper-like‚?Ě texture of his facial skin. He previously failed consecutive treatment with metronidazole 1% gel, clindamycin 1% gel, oral doxycycline 40 mg daily, Vbeam laser (Candela Corp, Wayland, MA), and isotretinoin 20 mg daily. His forehead and cheeks had multiple papulopustular lesions on a background of erythema. Most of his non‚??hair-bearing follicular orifices were noted to have minute, hyperkeratotic spicules protruding from their centers (). Potassium hydroxide microscopic examination of a pustule and the keratinous spicules revealed numerous Demodex mites. A¬†diagnosis of pityriasis folliculo...

Black-Boxed Drugs We Still Use: Weigh the Risk

The ‚??take home‚?Ě from this presentation: be cautious with inappropriate use of drugs with or without black box warnings, but maintain a healthy skepticism about some of these warnings. Cases in point: droperidol, antidepressants, clindamycin. (Source: Consultant Live)

Molecular and phenotypic evidence for the spread of three major methicillin-resistant Staphylococcus aureus clones associated with two characteristic antimicrobial resistance profiles in China

Conclusions The predominant MRSA clones in China were associated with characteristic antimicrobial resistance profiles. Antibiotics for treating patients with MRSA infections can be selected based on the strain typing data. (Source: Journal of Antimicrobial Chemotherapy)

Minocycline, often forgotten but preferred to trimethoprim‚??sulfamethoxazole or doxycycline for the treatment of community-acquired meticillin-resistant Staphylococcus aureus skin and soft-tissue infections

Abstract: Treatment of uncomplicated skin and soft-tissue abscesses caused by meticillin-sensitive Staphylococcus aureus or meticillin-resistant S. aureus (MRSA) is problematic. Incision and drainage aside, oral antibiotic therapy for uncomplicated community-acquired MRSA (CA-MRSA) is limited and frequent choices include clindamycin, doxycycline or trimethoprim‚??sulfamethoxazole (TMP‚??SMX). The most common oral antibiotics used for CA-MRSA are doxycycline or TMP‚??SMX, which often fail to eradicate the infection. With MRSA, in vitro susceptibilities do not always predict in vivo effectiveness. In situations where doxycycline or TMP‚??SMX fails in the treatment of uncomplicated cutaneous abscesses due to CA-MRSA, minocycline is reliably effective. (Source: International Journal of Antimic...<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>

Treatment of Infections Due to Resistant Staphylococcus aureus

This chapter reviews data on the treatment of infections caused by drug-resistant Staphylococcus aureus, particularly methicillin-resistant S. aureus (MRSA). This review covers findings reported in the English language medical literature up to January of 2013. Despite the emergence of resistant and multidrug-resistant S. aureus, we have seven effective drugs in clinical use for which little resistance has been observed: vancomycin, quinupristin&ndash;dalfopristin, linezolid, tigecycline, telavancin, ceftaroline, and daptomycin. However, vancomycin is less effective for infections with MRSA isolates that have a higher MIC within the susceptible range. Linezolid is probably the drug of choice for the treatment of complicated MRSA skin and soft tissue infections (SSTIs); whether it is drug of...

Epidemiology of Group B streptococcus Isolated from Pregnant Women in Beijing, China

This article is protected by copyright. All rights reserved. (Source: Clinical Microbiology and Infection)

The trend of macrolide resistance and emm types of group A streptococci from children at a medical center in southern Taiwan.

CONCLUSION: Increased resistance of GAS to macrolide and clindamycin was found in recent years. emm12 was the main serotype for macrolide resistance. PMID: 24094501 [PubMed - as supplied by publisher] (Source: Journal of Microbiology, Immunology, and Infection)

Prophylaxis and Treatment of Anthrax in Pregnant Women.

CONCLUSIONS:: Overall, safety and pharmacokinetic information is limited for these antimicrobials. Although small increases in risks for certain anomalies have been observed with some antimicrobials recommended for prophylaxis and treatment of anthrax, the absolute risk of these antimicrobials appears low. Given the high morbidity and mortality associated with anthrax, antimicrobials should be dosed appropriately to ensure that antibiotic levels can be achieved and sustained. Dosing adjustments may be necessary for the ő≤-lactam antimicrobials and the fluoroquinolones to achieve therapeutic levels in pregnant women. Data indicate that the ő≤-lactam antimicrobials, the fluoroquinolones, and, to a lesser extent, clindamycin enter the fetal compartment, an important consideration in the treat...

Systematic review on the rapidity of the onset of action of topical treatments in the therapy of mild‚?źto‚?źmoderate acne vulgaris

ConclusionFurther research is needed to identify treatments that offer an early onset of action and to possible help to optimise patient's adherence. Acne trials should consider including TOA as an additional outcome.This article is protected by copyright. All rights reserved. (Source: British Journal of Dermatology)<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>

Impact of retreatment with an artemisinin-based combination on malaria incidence and its potential selection of resistant strains: study protocol for a randomized controlled clinical trial

Background: Artemisinin-based combination therapy is currently recommended by the World Health Organization as first-line treatment of uncomplicated malaria. Recommendations were adapted in 2010 regarding rescue treatment in case of treatment failure. Instead of quinine monotherapy, it should be combined with an antibiotic with antimalarial properties; alternatively, another artemisinin-based combination therapy may be used. However, for informing these policy changes, no clear evidence is yet available. The need to provide the policy makers with hard data on the appropriate rescue therapy is obvious. We hypothesize that the efficacy of the same artemisinin-based combination therapy used as rescue treatment is as efficacious as quinine + clindamycin or an alternative artemisinin-based comb...

Hidradenitis suppurativa: A practical review of possible medical treatments based on over 350 hidradenitis patients.

This article centers on medical therapies and will only passingly mention surgical and laser treatments. This article summarizes my treatment experience with over 350 HS patients. PMID: 24021361 [PubMed - in process] (Source: Dermatol Online J)

Antibiotic resistance in Prevotella species isolated from patients with cystic fibrosis

Conclusions This study profiles antibiotic susceptibility in Prevotella spp. in CF and demonstrates that meropenem, piperacillin/tazobactam, chloramphenicol and metronidazole are likely to be the most effective antibiotics if treatment is indicated. (Source: Journal of Antimicrobial Chemotherapy)

Antibiotic Resistance and Capacity for Biofilm Formation of Different Bacteria Isolated from Endodontic Infections Associated with Root-filled Teeth

Conclusions: These results suggest that the clinical significance of endodontic infections could include that they serve as a reservoir for antibiotic resistance. Furthermore, endodontic treatment should consider the adhesion and biofilm formation by a variety of bacteria. (Source: Journal of Endodontics)

Antibiotic stewardship program; contextual environment and framework

Conclusions There were recommendations on how to adopt the Antibiotic Stewardship and the suggested framework, as well as recommendations about data collection, analysis and measurements for future implementation of the Program. Specific steps were encouraged based on the exact results of specific antibiotics such as flouroquinolones, clindamycin, vancomycin and IV administration and conversion to oral antibiotics (Source: Journal of Epidemiology and Community Health)<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>

Molecular characterization and antibiotic resistance of clinical isolates of methicillin‚?źresistant Staphylococcus aureus obtained from Southeast of Iran (Kerman)

Staphylococcus aureus infections, particularly infections caused by methicillin‚?źresistant S. aureus (MRSA) strains, are emerging as a major public health problem. The aim of this study was to determine the prevalence of MRSA, antibiotic resistance profile and staphylococcal cassette chromosome mec (SCCmec) type of MRSA isolates obtained from clinical samples. Totally, 162 S. aureus isolates were obtained from clinical samples at three university hospitals in Kerman, Iran from March 2011 to February 2012. All isolates were identified as S. aureus by phenotypic methods and confirmed by PCR amplification of the nuc gene. MRSA isolates were screened by phenotypic tests and confirmed by presence of mecA gene. The minimum inhibitory concentrations (MICs) of the MRSA isolates against antibacter...

Two anthrax cases with soft tissue infection, severe oedema and sepsis in Danish heroin users

Conclusions: These two heroin-associated anthrax cases from Denmark corroborate that heroin contaminated with anthrax spores may be a continuous source of injectional anthrax across Europe. Clinicians and clinical microbiologists need to stay vigilant and suspect anthrax in patients with a history of heroin use who present with soft tissue or generalised infection. Marked swelling of affected soft tissue or unusual intra-abdominal oedema should strengthen clinical suspicion. (Source: BMC Infectious Diseases)

Community-associated Clostridium difficile infection and antibiotics: a meta-analysis

Conclusions Antibiotic exposure was an important risk factor for CA-CDI, but the risk was different amongst different antibiotic classes. The risk was greatest with clindamycin followed by fluoroquinolones and cephalosporins, whereas tetracyclines were not associated with an increased risk. (Source: Journal of Antimicrobial Chemotherapy)

Preparation and Characterization of Chitosan-Based Spray-Dried Microparticles for the Delivery of Clindamycin Phosphate to Periodontal Pockets.

Authors: KńĪlńĪ√ßarslan M, G√ľm√ľŇ?taŇ? M, YńĪldńĪz S, Baykara T Abstract Biodegradable spray-dried chitosan microparticles loaded with clindamycin phosphate (CDP) were formulated to deliver drugs locally into the periodontal pocket. The effects of spray dryer conditions, drug/polymer ratio, and added amounts of glutaraldehyde (GA) solution on the characterization of microparticles were investigated by determining process yield, encapsulation efficiency, particle size and size distribution, surface morphology, drug release, release kinetics, thermal analysis, and antimicrobial efficacy of formulations. Burst releasewas obtained for all formulations due to the water solubility of the drug, but the increased amount of chitosan decreased the drug release rates. Microparticles with a m...

Non-Toxigenic Clostridium difficile Protects Hamsters Against Challenge with Historic and Epidemic Toxigenic BI/NAP1/027 C. difficile.

Conclusion:NTCD colonization provides protection against challenge with toxigenic BI group strains. M3 is more effective than T7 in preventing CDI caused by the BI6 epidemic strain. Prevention of C. difficile infection caused by epidemic BI6 may be more challenging than for historic BI1 and non-BI C. difficile strains. PMID: 23939887 [PubMed - as supplied by publisher] (Source: Antimicrobial Agents and Chemotherapy)<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>

Clindamycin-Induced Acute Kidney Injury: Large Biopsy Case Series.

Authors: Xie H, Chen H, Hu Y, Xu S, He Q, Liu J, Hu W, Liu Z Abstract Background: While clindamycin-induced acute kidney injury (AKI) is uncommon, it has occurred more frequently in recent years. Summary: We investigated 24 patients diagnosed with clindamycin-induced AKI retrospectively. The dosage of clindamycin was 1.0-1.5 g/day. Fifteen patients had episodes of gross hematuria, but fever, skin rash and eosinophilia were rare. Urine analysis revealed mild proteinuria and severe tubular dysfunction. Twenty-three patients were diagnosed with AKI stage 3 upon admission. The clindamycin lymphocyte transformation assay was positive for 63.2% of the patients. Acute interstitial nephritis (AIN) and acute tubular necrosis (ATN) were proven by renal biopsy, and renal insufficiency appeare...

Reply by the Authors

The authors of the letter provide insightful comments regarding the effect of initial antibiotics on the outcomes of sepsis from Fournier's gangrene in our study. We analyzed 41 patients with Fournier's gangrene during an 8-year study period with the specific aims of identifying the causative pathogens and evaluating the antibiotic sensitivity and resistance patterns. The resistance patterns were compared with the currently recommended antibiotic regimens to evaluate their efficacy and provide insight into future antibiotic recommendations. The traditionally recommended empiric coverage of ceftriaxone, gentamycin, and clindamycin, together, adequately covered every pathogen cultured in our study, suggesting this combination was appropriate for the treatment of our patients. Additionally, s...

Ludwig's Angina Triaged as an Allergic Reaction

A 59-year-old female presented to an emergency dental clinic with dental pain and minor left buccal and mandibular swelling. She was found to have fractured tooth 18. She was given clindamycin and told to return in several days for extraction. Overnight, she was febrile to 102¬įF and the swelling worsened to include her tongue. Believing this to be an allergic reaction to the antibiotic, she presented to the emergency department the following morning. Her vitals were normal with SpO2 92% on room air. The physical examination revealed bilateral submental erythema extending to the anterior neck, a muffled voice, mild tongue elevation with firm, and tender brawny edema to the floor of the mouth (). Despite the swelling and erythema of her neck, her airway was stable (). Laboratory studies rev...

Efficacy of vitamin C vaginal tablets as prophylaxis for recurrent bacterial vaginosis: a randomised, double-blind, placebo-controlled clinical trial.

CONCLUSIONS: The study showed that regular use of 250 mg ascorbic acid vaginal tablets on 6 days per month for 6 months after successful treatment of bacterial vaginosis halves the risk of recurrence from 32.4% to 16.2% (P = 0.024). PMID: 23864922 [PubMed] (Source: Clin Med Res)

The microbiota battle.

Authors: Jones L Abstract Antibiotic prophylaxis for laboring women with the intent of protecting newborns from group B strep (GBS) infection carries substantial risks and ethical shortcomings. GBS has been proven to be developing resistance to erythromycin and clindamycin. We are now seeing evidence of its resistance to penicillin, the recommended drug used in the prophylactic protocol. Bacterial resistance to antibiotics is linked to increased virulence of the bacteria. Considering the fact that robust bacterial flora throughout the body is essential to the health and well-being of new mothers and the bacterial colonization of their babies, perhaps the prophylactic use of antibiotics needs to be reconsidered. PMID: 23847897 [PubMed - in process] (Source: Midwifery Today with ...<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>

The protective effect of recombinant Lactococcus lactis oral vaccine on a Clostridium difficile-infected animal model

Conclusion: Recombinant L. lactis live vaccine is effective for preventing CDI in the hamster model, thus providing an alternative for immunization of C. difficile-associated diseases. (Source: BMC Gastroenterology)

A Method for generating marker-less gene deletions in multidrug-resistant Acinetobacter baumannii

Conclusions: The marker-less gene deletion method using pMo130-TelR is applicable for creating single and multiple gene deletions in MDR A. baumannii. The adeFGH and adeIJK operons were successfully deleted separately and together using this method and the impact of each efflux pump on antimicrobial resistance could be defined clearly. (Source: BMC Microbiology - Latest articles)

Cleocin Vaginal Ovules (Clindamycin Phosphate Vaginal Suppositories) - updated on RxList

(Source: RxList - New and Updated Drug Monographs)

Trends in the antimicrobial susceptibilities and serotypes of Streptococcus pneumoniae: results from the Tigecycline In Vitro Surveillance in Taiwan (TIST) study, 2006‚??2010

Abstract: Isolates of Streptococcus pneumoniae (n=530) were collected from 20 hospitals in different parts of Taiwan from 2006 to 2010. MICs to 16 antimicrobial agents were determined by broth dilution method and serotypes were identified by latex agglutination. Based on meningitis (non-meningitis) criteria established by the CLSI, 11.7% (63.2%) of all isolates were susceptible to penicillin and 46.0% (83.8%) were susceptible to ceftriaxone. Of the isolates, 94.3% were non-susceptible to azithromycin and 5.8% and 7.2% were non-susceptible to moxifloxacin and levofloxacin, respectively. Susceptibility to penicillin by meningitis criteria increased significantly (P=0.0012) with year, and that to clindamycin and amoxicillin/clavulanic acid declined significantly (P (Source: International Jour...

A unique strain of community-acquired Clostridium Difficile in severe complicated infection and death of a young adult

Conclusions: We believe that clindamycin used for coverage of a dental abscess was an independent risk factor that initiated the disruption of the bowel micro-flora, resulting in overgrowth of Clostridium difficile NAP12/ribotype 087. This uncommon strain, which is the same ribotype (087) as ATCC 43255, was apparently responsible for the increased severity of the infection and death following toxic megacolon, bowel perforation and pseudomembranous colitis involving the entire large bowel. K. pneumoniae sepsis, resolved by antibiotic therapy was secondary to Clostridium difficile infection. The case registers community-acquired Clostridium difficile infection as producing serious complications similar to hospital-acquired Clostridium difficile infection and should be treated with the requis...<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>

Tigecycline induction of phenol-soluble modulins by invasive MRSA strains.

We examined the effects of tigecycline on three exoproteins, PSMőĪ1-4, őĪ-hemolysin, and protein A, on 13 MRSA isolates compared to clindamycin and linezolid. Paradoxical increases of PSMőĪs occurred in 77% of isolates with tigecycline at &frac14; and &frac18; MICs and clindamycin at &frac18; MIC compared to only 23% of isolates with linezolid at &frac18; MIC. Induction was specific to PSMőĪ1-4, as protein A and őĪ-hemolysin production were decreased under the same conditions with all antibiotics. PMID: 23817369 [PubMed - as supplied by publisher] (Source: Antimicrobial Agents and Chemotherapy)

Serious group a streptococcal infections.

Authors: Wong CJ, Stevens DL Abstract The spectrum of illnesses caused by group A streptococcus (GAS) includes invasive infections, noninvasive infections, and noninfectious complications. Increasingly virulent infections associated with high morbidity and mortality have been observed since the late 1980s and continue to be prevalent in North America and worldwide. Penicillin remains the therapy of choice, with the addition of clindamycin recommended in high risk cases. Early recognition of GAS as the cause of these serious clinical syndromes is critical for timely administration of appropriate therapy. In this review, the pathophysiology, clinical manifestations, and treatment of invasive GAS infections are discussed. PMID: 23809722 [PubMed - in process] (Source: The Medical ...

Antianaerobic antimicrobials: spectrum and susceptibility testing.

Authors: Brook I, Wexler HM, Goldstein EJ Abstract SUMMARY Susceptibility testing of anaerobic bacteria recovered from selected cases can influence the choice of antimicrobial therapy. The Clinical and Laboratory Standards Institute (CLSI) has standardized many laboratory procedures, including anaerobic susceptibility testing (AST), and has published documents for AST. The standardization of testing methods by the CLSI allows comparisons of resistance trends among various laboratories. Susceptibility testing should be performed on organisms recovered from sterile body sites, those that are isolated in pure culture, or those that are clinically important and have variable or unique susceptibility patterns. Organisms that should be considered for individual isolate testing include hi...

Antibiotic Sensitivity and Resistance Patterns in Pediatric Staphylococcal Scalded Skin Syndrome

Abstract Historical resistance patterns often guide empiric antibiotic choices in staphylococcal scalded skin syndrome (SSSS), but little is known about the difference in susceptibility between SSSS and other childhood staphylococcal infections. A retrospective chart review of culture‚?źconfirmed cases of SSSS seen in the inpatient dermatology consultation service at the Children's Hospital of Philadelphia between 2005 and 2011 was performed. Most cases of SSSS at our institution are due to oxacillin‚?źsusceptible Staphylococcus aureus, and approximately half of the cases are due to clindamycin‚?źresistant strains. Clindamycin and a penicillinase‚?źresistant penicillin are suggested as empiric treatment for SSSS until culture susceptibility data are available to guide therapy. (Source: Ped...

Treatment of Staphylococcus aureus endocarditis with high doses of trimethoprim/sulfamethoxazole and clindamycin‚??Preliminary report

Infective endocarditis (IE) is still experiencing a high mortality rate even though this rate has been reduced in successive stages thanks to more focused antibiotics and increased indications for cardiac surgery, as is being confirmed in recent studies . Recently, following early surgery the mortality rate at Aix-Marseille Universit√© (Marseille, France) fell to 10% . However, a new increase in the number of deaths in our centre appears to be related to issues of time management and organisation in surgical treatment and, second, to the increase in the number of septic shocks related to Staphylococcus aureus . In fact, the early (‚?§3 months) fatality rate went from 9% (from 2000 to 2006) to 12% (from 2007 to 2008) and to 15% (from 2009 to 2011) (P=0.075 between the first and third groups...<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>

Corticosteroids in peritonsillar abscess treatment: A Blinded placebo‚?źcontrolled clinical trial

ConclusionsCombined with PTA drainage and IV antibiotics, 10 mg IV DEX resulted in less pain at 24 hours when compared to PLAC, without any serious side effects. This effect is short‚?źlived, and further research is required on factors associated with PTA treatment success. Level of Evidence1b Laryngoscope, 2013 (Source: The Laryngoscope)

Cutaneous manifestations of Nocardia brasiliensis infection in Taiwan during 2002‚??2012‚??clinical studies and molecular typing of pathogen by gyrB and 16S gene sequencing

Abstract: To observe the clinicopathologic and resistance profiles of the Nocardia brasiliensis causing cutaneous nocardiosis in Taiwan, 12 N. brasiliensis isolates were prospectively collected from patients with cutaneous nocardiosis in a hospital during 2002‚??2012. Clinicopathologic data were obtained, and isolates were identified by biochemical methods and 16S rRNA sequencing. Susceptibilities to 14 antimicrobial compounds were tested. Isolates were further genotyped by sequencing of 16S rRNA, secA1, hsp65, and gyrB genes. The nodulopustular pyoderma associated with sporotrichoid spreading was the most common skin presentations caused by N. brasiliensis. All of the isolates were susceptible to amikacin, gentamicin, tobramycin, piperacillin/tazobactam, and trimethoprim/sulfamethoxazole ...

Topical 4% nicotinamide vs. 1% clindamycin in moderate inflammatory acne vulgaris

This study aimed to compare efficacy of the topical 4% nicotinamide and 1% clindamycin gels in these patients. In this randomized, double‚?źblind clinical trial, patients with moderate inflammatory facial acne vulgaris were randomly allocated to receive either topical 4% nicotinamide (n¬†=¬†40) or 1% clindamycin gels (n¬†=¬†40) twice daily. In each group, they were further categorized in two subgroups with oily and non‚?źoily types of facial skin. The Cook's acne grade was determined at baseline and at weeks 4 and 8 post treatment. Acne grade decreased from an average of 5.93¬†¬Ī¬†0.83 at baseline to 4.03¬†¬Ī¬†1.33 at week 4 and 2.08¬†¬Ī¬†1.59 at week 8 in nicotinamide receivers, and from an average of 5.70¬†¬Ī¬†0.94 at baseline to 3.85¬†¬Ī¬†1.66 at week 4 and 2.03¬†¬Ī¬†1.53 at week 8 in t...

High rates of reduced susceptibility in the Bacteroides fragilis group isolated from blood cultures ‚?? The first national survey in Denmark

Bacteraemia with Bacteroides fragilis group species is associated with high mortality rates if appropriate antimicrobial therapy is not administered . Increasing resistance in the B. fragilis group has been reported worldwide, especially towards clindamycin and piperacillin/tazobactam (TZP) . Lately, resistance towards the carbapenems and metronidazole has been reported, and a recent study by Toprak et al. demonstrated an alarmingly high number of isolates (27%) from a Turkish University Hospital harbouring the cfiA gene associated with carbapenem resistance . At Odense University Hospital in Denmark, 10.2% (9/88) of B. fragilis group blood culture isolates from a 3-year period (November 2007‚??November 2010) had reduced susceptibility (intermediate-susceptible or resistant) towards merope...<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>

Foreword

Clostridium difficile was first reported as the cause of antibiotic-associated colitis in 1978. Over the subsequent 3 decades, we have witnessed a dramatic increase in the incidence and severity of infections with this organism. Today, not only do surgeons encounter pseudomembranous colitis in their own postoperative patients but they are frequently called upon to intervene in patients with the most severe disease. In this issue of Current Problems in Surgery, Drs J. Daniel Stanley, John Bartlett, Benjamin Dart, and John Ashcraft have written a masterful overview on this topic entitled, ‚??Clostridium difficile Infection.‚?Ě They begin with a discussion of the history of this often hospital-acquired infection, including its association with clindamycin therapy and the development of more v...

Molecular epidemiology of vancomycin-resistant enterococcal bacteraemia: results from the Canadian Nosocomial Infection Surveillance Program, 1999-2009

Conclusions The increase in bacteraemia observed since 2007 in western and central Canada appears to coincide with the shift of MLST STs. All VRE isolates remained susceptible to daptomycin, linezolid, chloramphenicol and tigecycline. (Source: Journal of Antimicrobial Chemotherapy)

Effects of subinhibitory concentrations of antibiotics on virulence factor expression by community-acquired methicillin-resistant Staphylococcus aureus

Conclusions The effect of sub-MICs on virulence expression depended on the antibiotic and the virulence factor. Clindamycin and linezolid consistently suppressed the expression of different virulence factors by CA-MRSA, whereas tigecycline specifically suppressed PVL expression. Daptomycin and vancomycin seem to have no significant effects at these concentrations. (Source: Journal of Antimicrobial Chemotherapy)

Characterization of swine isolates of Clostridium difficile in Spain: a potential source of epidemic multidrug resistant strains?

We present the first report on the ribotype distribution and antimicrobial susceptibility of C. difficile in swine in Spain. A total of 144 isolates were PCR ribotyped, and their MIC values for 13 antimicrobial agents were determined using the Etest. Toxin A and B production was assessed using a commercial immunoassay and, in the case of toxin B, a specific cytotoxicity test. Our results show a high prevalence of the toxigenic 078 ribotype (94.4%) and multidrug resistance (49.3%) among the studied isolates. A minority of isolates (5.6%) belonged to a mostly non-toxinogenic ribotype. All isolates were resistant to the fluoroquinolone ciprofloxacin, but susceptible to daptomycin, linezolid, meropenem, rifampicin, teicoplanin, tigecycline, metronidazole and vancomycin. Resistance to clindamyc...

CLINDAMYCIN HYDROCHLORIDEcapsule [REMEDYREPACK INC. ]

Updated Date: Jun 3, 2013 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>

Characteristics of Group A Streptococcus Strains Circulating during Scarlet Fever Epidemic, Beijing, China, 2011.

Authors: Yang P, Peng X, Zhang D, Wu S, Liu Y, Cui S, Lu G, Duan W, Shi W, Liu S, Li J, Wang Q Abstract Scarlet fever is one of a variety of diseases caused by group A Streptococcus (GAS). During 2011, a scarlet fever epidemic characterized by peak monthly incidence rates 2.9-6.7 times higher than those in 2006-2010 occurred in Beijing, China. During the epidemic, hospital-based enhanced surveillance for scarlet fever and pharyngitis was conducted to determine characteristics of circulating GAS strains. The surveillance identified 3,359 clinical cases of scarlet fever or pharyngitis. GAS was isolated from 647 of the patients; 76.4% of the strains were type emm12, and 17.1% were emm1. Almost all isolates harbored superantigens speC and ssa. All isolates were susceptible to penicilli...

Antimicrobial susceptibility and molecular typing of MRSA in cystic fibrosis

ConclusionsIn this U.S. study, most MRSA isolates in the pediatric CF population were SCCmec II PVL negative. Rates of resistance were low, including to older and orally available antibiotics such as trimethoprim‚??sulfamethoxazole. Pediatr Pulmonol. ¬© 2013 Wiley Periodicals, Inc. (Source: Pediatric Pulmonology)

[Emergence of high-level resistance to gentamicin and streptomycin in Streptococcus agalactiae in Buenos Aires, Argentina].

Conclusions. This study highlights the emergence of strains with HLR to aminoglycosides. The disk-agar diffusion test performed with high-content aminoglycoside disks and screening plates can provide laboratories with a convenient and reliable method for detecting S. agalactiae isolates that are resistant to aminoglycoside-betalactam synergy. PMID: 23817648 [PubMed - in process] (Source: Revista Espanola de Quimioterapia)

A probable case of acquired toxoplasmosis presenting as pyrexia of unknown origin in an immunocompetent individual

We report a probable case of acquired toxoplasmosis in an immunocompetent woman who presented with fever of 6 months duration with lymphadenopathy and splenomegaly. The diagnosis was confirmed by serology and the presence of Toxoplasma gondii tachyzoites on bone marrow aspirate. The patient was successfully treated with pyrimethamine plus clindamycin. (Source: International Journal of Infectious Diseases)

CLINDAMYCIN HYDROCHLORIDEcapsule [REMEDYREPACK INC. ]

Updated Date: May 28, 2013 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>

Linezolid Desensitization for a Patient with Multiple Medication Hypersensitivity Reactions (July/August).

CONCLUSIONS:Linezolid desensitization can be a viable option in patients requiring antimicrobial therapy for complicated gram-positive skin infections. PMID: 23715068 [PubMed - as supplied by publisher] (Source: The Annals of Pharmacotherapy)

Antibiotic resistance patterns among group B Streptococcus isolates: implications for antibiotic prophylaxis for early-onset neonatal sepsis.

CONCLUSION: Rates of clindamycin and erythromycin resistance are also increasing in our context. These antibiotics should not be used for GBS neonatal sepsis prevention, without adequate antimicrobial susceptibility testing. In case of penicillin allergy and lack of antibiogramm, cephalosporins or vancomycin should be used as recommended in CDC guidelines. PMID: 23572445 [PubMed - in process] (Source: Swiss Medical Weekly)

Active screening of group B streptococci with reduced penicillin susceptibility and altered serotype distribution isolated from pregnant women in Kobe, Japan.

Authors: Kimura K, Matsubara K, Yamamoto G, Shibayama K, Arakawa Y Abstract Group B streptococcus (GBS; Streptococcus agalactiae) is a leading cause of neonatal invasive infections and was believed to be fully susceptible to penicillin. However, we recently identified several clinical GBS isolates with reduced penicillin susceptibility (PRGBS), which were mainly isolated from respiratory specimens of elderly people. An investigation of both the isolation rate of PRGBS and the serotype distribution among pregnant women is crucial to decisions regarding optimal prevention and strategies for GBS treatment in neonates. We collected 141 GBS isolates from vaginal specimens of 122 pregnant women in a hospital in Kobe, Japan, from 2007 to 2008. Of the 141 GBS isolates, 139 were subjected t...

Management of intratonsillar abscess in children

ConclusionsClinically stable children with intratonsillar abscess or phlegmon respond to trial of intravenous antibiotic therapy. Surgical drainage can accomplish clinical resolution in the presence of combination of intra‚?ź and peri‚?źtonsillar abscess, airway compromise, or unresponsiveness to medical treatment. (Source: Pediatrics International)

Peritoneal dialysis peritonitis by anaerobic pathogens: a retrospective case series

Conclusion: Anaerobic PD-associated peritonitis might be predominantly caused by contamination, rather than intra-abdominal events. Half of anaerobic PD-associated peritonitis episodes had polymicrobial growth. The overall outcome of anaerobic peritonitis is fair, with a high catheter survival rate. (Source: BMC Nephrology)<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>

Antimicrobial resistance and co-selection phenomenon in Listeria spp. recovered from food and food production environments.

Authors: Kovacevic J, Sagert J, Wozniak A, Gilmour MW, Allen KJ Abstract Antimicrobial resistance (AMR), co-selection phenomenon, and the relationship between reduced susceptibility (RSC) to ciprofloxacin (CIP) and resistance to other antimicrobials in Listeria spp. (n = 103) recovered from food processing environments (FPE) and food were investigated. Resistance of Listeria monocytogenes and other listeriae, respectively, to cefoxitin (FOX; 98% vs. 88%), CIP (7% vs. 4%), clindamycin (CLI; 33% vs. 59%) and tetracycline (6% vs. 8%) was observed, as was RSC to CIP (67% vs. 57%) and CLI (65% vs. 41%). L. monocytogenes also possessed RSC to linezolid (LZD; 6%), rifampicin (2%) and streptomycin (6%), with other listeriae displaying RSC to chloramphenicol (4%). L. monocytogenes serot...

Scarce detection of mobile erm genes associated with tetQ in Bacteroides and Parabacteroides from Costa Rica.

Authors: Quesada-Gómez C, Rodríguez-Cavallini E, Rodríguez C Abstract The frequency of finding of clindamycin-resistant anaerobic bacteria in clinical samples has doubled from 2008 to 2010 in Costa Rica. To determine whether this increase is due to dissemination of erm genes aided by tetQ elements, we analyzed 100 isolates of Bacteroides or Parabacteroides from a regional hospital, a national hospital, and the community. Antimicrobial susceptibilities were recorded with a broth micro-dilution method and erm genes were detected by PCR and Southern blotting. In addition, plasmid isolation and mating experiments were performed to clarify the location and mobility of the detected erm genes. Resistance to clindamycin was by far more frequent in the regional hospital (72%) than in the...

The prevalence of antibiotic resistance genes in Bacteroides fragilis group strains isolated in different European countries.

Authors: Eitel Z, S√≥ki J, Urb√°n E, Nagy E, ESCMID Study Group on Anaerobic Infection Abstract From the 2008-2009 European Bacteroides antibiotic resistance survey, we selected 161 strains for detection of antibiotic resistance genes (cepA, cfxA, cfiA, nim, ermB, ermF, ermG, linA, mefA, msrSA, tetM, tetQ, tetX, tetX1, tet36 and bexA). To facilitate the throughput, the genes were detected by Real-Time PCR. The presence of the genes was correlated with the known MIC data of the strains for the appropriate antibiotics. For the ő≤-lactams, the cepA gene was found in 70.8% of the tested strains (all resistant to ampicillin), but its presence did not correlate with the ampicillin MIC values. The cepA gene occurred at different frequencies among Bacteroides fragilis and non-fragilis Bact...

Eradication of chronic methicillin-resistant Staphylococcus aureus infection in cystic fibrosis patients. An observational prospective cohort study of 11 patients

Conclusion: Chronic MRSA infection can be eradicated from respiratory tract samples using a six month dual antibiotic regimen and topical MRSA decolonization measures. (Source: Journal of Cystic Fibrosis)

Antimicrobial Resistance, Virulence Genes, and Genetic Lineages of Staphylococcus pseudintermedius in Healthy Dogs in Tunisia.

Authors: Gharsa H, Ben Slama K, Gómez-Sanz E, Lozano C, Klibi N, Jouini A, Messadi L, Boudabous A, Torres C Abstract Nasal swabs of 100 healthy dogs were obtained in 2011 in Tunisia and tested for Staphylococcus pseudintermedius recovery. Antimicrobial resistance profile and virulence gene content were determined. Multilocus-sequence-typing (MLST) and SmaI-pulsed-field gel electrophoresis (PFGE) were investigated. S. pseudintermedius was recovered in 55 of the 100 tested samples (55 %), and one isolate per sample was further studied. All 55 S. pseudintermedius isolates were susceptible to methicillin (MSSP) but showed resistance to the following antimicrobials (% resistant isolates/resistance gene): penicillin (56.4/blaZ), tetracycline (40/tetM), trimethoprim-sulfamethoxazole (23...<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>

Nasal carriage and antimicrobial susceptibility of Staphylococcus aureus among medical students at the HRH Princess Maha Chakri Sirindhorn Medical Center, Thailand: A cross sectional study

Conclusions: The prevalence of asymptomatic nasal carriage of S. aureus was higher than reported by previous literature in Thailand, and S. aureus isolates exhibited relatively high resistance to erythromycin and clindamycin. (Source: Journal of Infection and Public Health)

Antimicrobial resistance of Enterococcus species from meat and fermented meat products isolated by a PCR-based rapid screening method.

Authors: Jahan M, Krause DO, Holley RA Abstract Enterococci are predominantly found in the gastrointestinal tract of humans and animals, but species commonly resident on vegetation are known. Their presence in large numbers in foods may indicate a lapse in sanitation and their ability to serve as a genetic reservoir of transferable antibiotic resistance is of concern. Conventional culture methods for identification of enterococci are slow and sometimes give false results because of the biochemical diversity of the organisms in this genus. This work reports the development of a PCR-based assay to detect enterococci at the genus level by targeting a 16S rRNA sequence. Published 16S rRNA sequences were aligned and used to design genus specific primers (EntF and EntR). The primers were...

Detection of Methicillin-Susceptible Staphylococcus aureus ST398 and ST133 Strains in Gut Microbiota of Healthy Humans in Spain.

Authors: Benito D, Lozano C, G√≥mez-Sanz E, Zarazaga M, Torres C Abstract Fecal samples of 100 healthy humans were tested for Staphylococcus aureus recovery. Fifteen samples (15¬†%) contained S. aureus, all methicillin-susceptible (MSSA), being one isolate/sample further studied. These 15 isolates were characterized by spa and agr typing as well as multi-locus sequence typing. High diversity of spa types (n‚??=‚??11) and sequences types (n‚??=‚??8) was detected. Two S. aureus of lineages ST398 or ST133 were detected, and six isolates were ascribed to clonal complex 30 (CC30). Strains were susceptible to most of the 17 antimicrobial agents tested with exceptions: erythromycin/clindamycin (three strains, containing erm(C) and/or erm(A) + mph(C) genes) and tobramycin and mupirocin (on...

Changes in serotype prevalence and antimicrobial resistance among invasive Streptococcus pneumoniae isolates in Korea, 1996-2008.

Authors: Lee S, Bae S, Lee KJ, Yu JY, Kang Y Abstract We investigated changes in serotypes and antimicrobial susceptibilities among 386 isolates of invasive Streptococcus pneumoniae collected from numerous hospitals in Korea from 1996-2008. Serotype 19F (9.8%), 23F (8.3%), 19A (7.8%), 6A (7.5%), 3 (7.3%), 9V (6.5%), 6B (6.2%), 14 (4.9%), 1 (3.9%), 11A (3.9%) and 4 (3.1%) represented 69.2% of all isolates. While the overall proportion of PCV7 serotypes was stable over time, we observed modest decreases in children &lt; 5-years-of-age and adults ‚?• 65-years-of-age between 1996-1999 and 2007-2008. An increased prevalence of non-PCV7 serotypes in these age groups was primarily attributable to an increase in serotypes 3, 6A and 19A. Most invasive S. pneumoniae isolates showed high resi...

CLINDAMYCIN PALMITATE HYDROCHLORIDE (PEDIATRIC)Solution [Aurobindo Pharma Limited]

Updated Date: May 3, 2013 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>

CLEOCIN PHOSPHATE (Clindamycin Phosphate) Injection, Solution [Pharmacia And Upjohn Company]

Updated Date: May 2, 2013 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

Acute generalized exanthematous pustulosis with multiple organ dysfunction syndrome.

Authors: Mohyuddin GR, Al Asad M, Scratchko L, Khaleeq G Abstract Acute generalized exanthematous pustulosis is a rare condition characterized by sterile pustules on erythematous and edematous tissue. Mostly drug induced, this condition can also be caused by other factors. Cases due to vancomycin are rare. A 67-year-old woman with cellulitis of the left lower extremity was admitted with marked bilateral lymphedema of the lower extremities and diffuse erythema of the left lower extremity from foot to knee. She was given clindamycin and then vancomycin. On day 5, her condition worsened, with erythema involving the entire back. Although treatment with clindamycin and vancomycin was discontinued, acute generalized exanthematous pustulosis developed. After successful treatment of other ...

Healthy 51-Year-Old Male With Peritonsillar Swelling

[Ann Emerg Med. 2013;61:520.] A 51-year-old healthy man was sent to the emergency department for evaluation of a peritonsillar abscess after 3 weeks of sore throat and completion of a course of clindamycin. He had developed odynophagia to solids and observed purulent drainage from the back of his mouth. Systemic symptoms were absent, the patient's vital signs were normal, and a right-sided peritonsillar mass was observed on oropharyngeal examination (). Bedside intracavitary ultrasonography was performed (), and needle aspiration of the peritonsillar mass was attempted under ultrasonographic guidance. A small amount of yellow-pink fluid was sent for analysis. Otolaryngology was consulted and computed tomography (CT) of the neck was performed (). (Source: Annals of Emergency Medicine)

Serious Group A Streptococcal Infections

The spectrum of illnesses caused by group A streptococcus (GAS) includes invasive infections, noninvasive infections, and noninfectious complications. Increasingly virulent infections associated with high morbidity and mortality have been observed since the late 1980s and continue to be prevalent in North America and worldwide. Penicillin remains the therapy of choice, with the addition of clindamycin recommended in high risk cases. Early recognition of GAS as the cause of these serious clinical syndromes is critical for timely administration of appropriate therapy. In this review, the pathophysiology, clinical manifestations, and treatment of invasive GAS infections are discussed. (Source: Medical Clinics of North America)

Presence of Inducible Clindamycin Resistance Phenotype and erm Genes in Foodborne Staphylococcus aureus Isolates

Foodborne Pathogens and Disease , Vol. 0, No. 0. (Source: Foodborne Pathogens and Disease)<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>

Microbiology and antimicrobial treatment of pediatric cervical lymphadenitis requiring surgical intervention

Conclusions: A single antibiotic that treats S. pyogenes and S. aureus should be the empiric antibiotic for cervical lymphadenitis requiring incision and drain. We recommend sending only aerobic cultures intraoperatively as a routine practice as other pathogens are rare. (Source: International Journal of Pediatric Otorhinolaryngology)

In vitro susceptibility to antibiotics of staphylococci in biofilms isolated from orthopaedic infections

Abstract: Prosthetic joint infections (PJIs) are related to the formation of biofilms, mainly by Staphylococcus aureus and Staphylococcus epidermidis. Therapy is usually selected according conventional susceptibility testing, but these data may be insufficient to detect the true antibiotic susceptibility in the biofilm. In total, 32 clinical strains (17 S. aureus and 15 S. epidermidis) isolated from patients with PJIs as well as 2 collection strains (S. aureus 15981 and S. epidermidis ATCC 35984) were tested against nine antibiotics commonly used in the treatment of PJIs (rifampicin, vancomycin, tigecycline, clindamycin, trimethoprim/sulfamethoxazole, ciprofloxacin, cloxacillin, daptomycin and fosfomycin) using the Calgary Biofilm Device. None of the antibiotics proved to be totally effect...

CLINDESSE (Clindamycin Phosphate) Cream [Ther-Rx Corporation]

Updated Date: Apr 17, 2013 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

CLINDAMYCIN HYDROCHLORIDE ORAL DROPS (Clinamycin Hydrochloride) Liquid [FIRST PRIORITY INCORPORATED]

Updated Date: Apr 16, 2013 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

CLINDAMYCIN (Clindamycin Phosphate) Injection [Akorn, Inc.]

Updated Date: Apr 8, 2013 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>

[Rational approach of antibioprophylaxis: Systematic review in ENT cancer surgery.]

Authors: Garnier M, Blayau C, Fulgencio JP, Baujat B, Arlet G, Bonnet F, Quesnel C Abstract In head and neck cancer surgery antibiotic prophylaxis is effective in reducing the incidence of surgical site infections (SSI). However, controversies between antibiotic prophylaxis and curative antibiotic therapy exist, particularly when complex and decaying surgeries are performed in risky underlying conditions, with a risk of persisting salivary effusion in the postoperative period, or in the case of reconstruction with myo-cutaneous flaps. We have performed a systematic review of the literature according to PRISMA recommendations to answer the following questions: indications for antibiotic prophylaxis and curative antibiotic therapy, optimal duration, and choice of antibiotics for prop...

Antibiotic resistance in human peri‚?źimplantitis microbiota

ConclusionsPeri‚?źimplantitis patients frequently yielded submucosal bacterial pathogens resistant in vitro to individual therapeutic concentrations of clindamycin, amoxicillin, doxycycline, or metronidazole, but only rarely to both amoxicillin and metronidazole. Due to the wide variation in observed drug resistance patterns, antibiotic susceptibility testing of cultivable submucosal bacterial pathogens may aid in the selection of antimicrobial therapy for peri‚?źimplantitis patients. (Source: Clinical Oral Implants Research)

In vitro activity of cadazolid against Clostridium difficile strains isolated from primary and recurrent infections in Stockholm, Sweden.

Authors: Rashid MU, Lozano HM, Weintraub A, Nord CE Abstract One hundred thirty-three Clostridium difficile strains were collected from 71 patients and analyzed for the presence of C. difficile toxin B by the cell cytotoxicity neutralization assay, genes for toxin A, toxin B, binary toxin and TcdC deletion by PCR. All strains were also PCR-ribotyped and analyzed for sporulation frequency. The MICs of the isolates were determined against cadazolid and seven other antimicrobial agents by the agar dilution method. All isolates were positive for toxin B by the cell cytotoxicity neutralization assay. One hundred fourteen isolates were positive for toxin A and B and 16 isolates were positive for toxin A, toxin B and binary toxin by PCR. Three isolates were negative for toxin A but posi...

Pharmacokinetics of antibacterial agents in the CSF of children and adolescents.

Authors: Sullins AK, Abdel-Rahman SM Abstract The adequate management of central nervous system (CNS) infections requires that antimicrobial agents penetrate the blood-brain barrier (BBB) and achieve concentrations in the CNS adequate for eradication of the infecting pathogen. This review details the currently available literature on the pharmacokinetics (PK) of antibacterials in the CNS of children. Clinical trials affirm that the physicochemical properties of a drug remain one of the most important factors dictating penetration of antimicrobial agents into the CNS, irrespective of the population being treated (i.e. small, lipophilic drugs with low protein binding exhibit the best translocation across the BBB). These same physicochemical characteristics determine the primary dispo...

Not What It Looks Like: A Transient Cardiomyopathy

Significant cardiac signs and symptoms developed in a young patient undergoing treatment for a severe infection. The 23-year-old man presented with a left groin abscess and a 5-day history of fever. Computed tomography (CT) showed findings consistent with fasciitis (). He was initially treated with intravenous vancomycin, ampicillin-sulbactam, and clindamycin. On hospital day 2, he developed severe chest pain, dyspnea, and nonsustained ventricular tachycardia. (Source: The American Journal of Medicine)<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>

Comparison of methicillin-resistant Staphylococcus aureus strains isolated in 2003 and 2008 with an emergence of multidrug resistant ST22: SCCmec IV clone in a tertiary hospital, Malaysia.

CONCLUSION: Vancomycin remains the most active agent in vitro against S. aureus infection followed by linezolid and teicoplanin. The prevalence of resistance to fluoroquinolones, aminoglycosides (netilmicin), and tetracyclines had increased over the years. The Malaysian multidrug-resistant MRSA isolates were mostly SCCmec type III and ST239, although SCCmec type IV: ST22 is gaining importance. There was a correlation between resistotypes and PFGE profiles. PMID: 23523045 [PubMed - as supplied by publisher] (Source: Journal of Microbiology, Immunology, and Infection)

Physical compatibility of various drugs with neonatal total parenteral nutrient solution during simulated Y-site administration.

CONCLUSION: Caffeine citrate, clindamycin, enalaprilat, epinephrine, fluconazole, fosphenytoin sodium, hydrocortisone, metoclopramide, and midazolam exhibited no visual or turbidimetric evidence of incompatibility when combined with a neonatal TPN solution for up to three hours in a simulated Y-site injection. Amiodarone, pentobarbital, phenobarbital, and rifampin were not compatible with the neonatal TPN solution and should not be coadministered via Y-site injection. PMID: 23456406 [PubMed - in process] (Source: American Journal of Health-System Pharmacy : AJHP)

Prevalence, Antimicrobial Resistance, and Virulence Characteristics of mecA‚?źEncoding Coagulase‚?źNegative Staphylococci Isolated from Soft Cheese in Brazil

This study highlights the extent of the antimicrobial resistance phenomenon in neglected foodborne microorganisms and the potential public health risks that are related to the consumption of CoNS‚?źcontaminated soft cheese. (Source: Journal of Food Science)

Odontogenic Abscess

A 56-year-old diabetic man presented to the Emergency Department with dysphagia, odynophagia, fever, and pronounced neck swelling for 5 days. On arrival to the Emergency Department, the patient was afebrile and protecting his airway. Physical examination revealed poor dentition without pooled secretions or elevated floor of his mouth. He had a large, indurated, submental mass just lateral to the trachea. Intravenous hydration and clindamycin were administered. Otolaryngology surgery accompanied the patient for a computed tomography scan followed by surgical exploration. Intraoperatively, a 13-cm submandibular abscess was successfully drained (). Antibiotics were continued with favorable results. (Source: The Journal of Emergency Medicine)

Antimicrobial susceptibility of Propionibacterium acnes isolates from acne patients in Colombia

Conclusions‚?? Antimicrobial resistance in P.¬†acnes in this Colombian population has a lower prevalence than those reported in Europe and follows a similar pattern to findings elsewhere in Latin America. Resistance is demonstrated even in isolates from patients with no previous history of antibiotic use. Resistance to erythromycin is most commonly observed. Minocycline emerges as the most effective antibiotic. (Source: International Journal of Dermatology)<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>

Oral clindamycin and rifampicin in the treatment of hidradenitis suppurativa‚?źacne inversa: a prospective study on 23 patients

(Source: Journal of the European Academy of Dermatology and Venereology)

Antibiotics for treating bacterial vaginosis in pregnancy.

CONCLUSIONS: Antibiotic treatment can eradicate bacterial vaginosis in pregnancy. The overall risk of PTB was not significantly reduced. This review provides little evidence that screening and treating all pregnant women with bacterial vaginosis will prevent PTB and its consequences. When screening criteria were broadened to include women with abnormal flora there was a 47% reduction in preterm birth, however this is limited to two included studies. PMID: 23440777 [PubMed - in process] (Source: Cochrane Database of Systematic Reviews)

Comparing a combination of penicillin G and gentamicin to a combination of clindamycin and amikacin as prophylactic antibiotic regimens in prevention of clean contaminated wound infections in cancer surgery.

CONCLUSION: Both penicillin+gentamicin and clindamycin+amikacin are safe and effective for the prevention of SSI in clean contaminated operative procedures. In a resource limited hospital, a regimen including penicillin+gentamicin is a cost-effective alternative for the more expensive and broader coverage of clindamycin+amikacin. Timing of PA is effective in preventing SSIs when administered 30min before the start of surgery. PMID: 23499204 [PubMed - in process] (Source: J Egypt Natl Canc In...)

Isolation, molecular characterization and antimicrobial susceptibilities of isolates of Mycoplasma agalactiae from bulk tank milk in an endemic area of Spain

ConclusionsBased on the in vitro assay clindamycin, the quinolones, tylosin and tilmicosin would be appropriate antimicrobials for contagious agalactia treatment. The isolates were mostly resistant to erythromycin, indicating that it would not be a suitable choice for therapy. The isolates showed common molecular and protein profiles by PFGE and SDS‚?źPAGE, with minor differences observed by immunoblot analysis, suggesting a clonal relationship among them. Significance and impact of studyThis study demonstrated the importance of the appropriate selection of antimicrobials for treatment of contagious agalactia.¬© 2013 The Authors Journal of Applied Microbiology ¬© 2013 The Society for Applied Microbiology (Source: Journal of Applied Microbiology)

Antimicrobial susceptibility and genetic characteristics of Propionibacterium acnes isolated from patients with acne

Conclusions‚?? Resistance to trimethoprim‚??sulfamethoxazole was the most common pattern found, and further studies are required to clarify its resistance mechanism. A certain tetracycline resistance was expected, but interestingly all strains remained sensitive. Resistance to erythromycin and clindamycin were influenced using topical formulations. Mutation A2059G was related to high resistance to erythromycin. Antibiotic resistance is increasing, and new strategies are needed. (Source: International Journal of Dermatology)<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>

Causative Pathogens, Antibiotic Sensitivity, Resistance Patterns, and Severity in a Contemporary Series of Fournier's Gangrene

Conclusion: Fournier's gangrene remains a community-acquired polymicrobial infection, with anaerobic bacteria as the most common causative pathogens. Candida and methicillin-resistant S aureus are emerging causative pathogens, but methicillin-resistant S aureus remains sensitive to clindamycin and trimethoprim/sulfamethoxazole. Although resistance was demonstrated by some causative pathogens, together, the currently recommended broad-spectrum antibiotics adequately covered all pathogens. Coverage with agents such as fluconazole, vancomycin, or piperacillin-tazobactam is indicated in patients at risk of fungal or hospital-acquired organisms. (Source: Urology)

Clindamycin: Fatal DRESS syndrome: case report

(Source: Reactions)

Antimicrobial Prophylaxis and Outpatient Management of Fever and Neutropenia in Adults Treated for Malignancy: American Society of Clinical Oncology Clinical Practice Guideline [ASCO SPECIAL ARTICLES]

Purpose To provide guidelines on antimicrobial prophylaxis for adult neutropenic oncology outpatients and on selection and treatment as outpatients of those with fever and neutropenia. Methods A literature search identified relevant studies published in English. Primary outcomes included: development of fever and/or infections in afebrile neutropenic outpatients and recovery without complications and overall mortality in febrile neutropenic outpatients. Secondary outcomes included: in afebrile neutropenic outpatients, infection-related mortality; in outpatients with fever and neutropenia, defervescence without regimen change, time to defervescence, infectious complications, and recurrent fever; and in both groups, hospital admissions, duration, and adverse effects of antimicrobials. An Ex...

Bacteraemias in tropical Australia: changing trends over a 10-year period

Abstract: Bacteraemia is an important cause of morbidity and mortality worldwide. This is the largest reported study of bacteraemias in Australia. The presence of organisms endemic to the tropical region and the changing trends described have significant implications for empirical antibiotic therapy. This retrospective study examined 8976 blood cultures from Townsville Hospital, a regional Australian hospital located in the tropics over a 10-year period. The rate of bacteraemic episodes during the study period was 10.12 per 1000 admissions. Intravenous devices (18.7%), immunosuppressive therapy (16.1%), and urinary tract infections (16.1%) were important sources for bacteraemia. The most common organisms were Staphylococcus aureus (20.9%) and Escherichia. coli (15.6%). A significant reduct...

CLINDAMYCIN PHOSPHATEsolution [VersaPharm Incorporated]

Updated Date: Feb 13, 2013 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>

How Important Are Anaerobic Bacteria in Aspiration Pneumonia: When Should They Be Treated and What Is Optimal Therapy

Anaerobic bacteria are infrequent pulmonary pathogens, and, even then they are, they are almost never recovered due to the need for specimens uncontaminated by the upper airway flora and failure to do adequate anaerobic bacteriology. These bacteria are relatively common in selected types of lung infections including aspiration pneumonia, lung abscess, necrotizing pneumonia and emphyema. Preferred antibiotics for these infections based on clinical experience are clindamycin and any betalactam-betalactamase inhibitor. (Source: Infectious Diseases Clinics of North America)

CLINDAMYCIN IN 5 PERCENT DEXTROSEinjection, Solution [Sandoz Inc]

Updated Date: Feb 11, 2013 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

Experimental Evidence that Granulocyte Transfusions are Efficacious in Treatment of Neutropenic Hosts with Pulmonary Aspergillosis.

Conclusion:Our present results provide an experimental basis for enthusiasm for PMN transfusions in the therapy of aspergillosis in man. PMID: 23380731 [PubMed - as supplied by publisher] (Source: Antimicrobial Agents and Chemotherapy)

Macrolides inhibit Fusobacterium nucleatum-induced MUC5AC induction in human airway epithelial cells.

In this study, we examined whether Fn induces mucin secretion in airway epithelial cells. We also examined the effects of macrolides on the Fn-induced mucus production compared with other antibiotics that exert anti-anaerobic activities. MUC5AC production in bronchial epithelial cells after stimulation with culture supernatants (Sup) of Fn was analyzed by performing enzyme-linked immunosorbent assay and quantitative RT-PCR. The cell-signaling pathway of Fn Sup stimulation was also analyzed by performing Western blotting. For inhibition studies, cells were treated with azithromycin, clarithromycin, clindamycin (CLDM), and metronidazole (MTZ). The Fn Sup-induced NCI-H292 cells to express MUC5AC at both the protein levels and the mRNA level in both a time- and dose-dependent manner. Macrolide...

CLINDAMYCIN HYDROCHLORIDEcapsule [Mylan Pharmaceuticals Inc.]

Updated Date: Feb 1, 2013 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>

Methicillin resistant Staphylococcus aureus (MRSA) in India: prevalence & susceptibility pattern.

CONCLUSIONS: The study showed a high level of MRSA in our country. There is a need to study epidemiology of such infections. Robust antimicrobial stewardship and strengthened infection control measures are required to prevent spread and reduce emergence of resistance. PMID: 23563381 [PubMed - in process] (Source: The Indian Journal of Medical Research)

[Detection of anaerobes and drug sensitivity from the periodontal pockets of patients with combined periodontal-endodontic lesions].

CONCLUSIONS: There is a close relationship between anaerobes and combined periodontal-endodontic lesions. Drug sensitive susceptibility should be detected prior to clinical treatment of combined periodontal-endodontic lesions. Supported by Key Medical Discipline Project of Bureau of Health of Yangpu District (2009AA02-09). PMID: 23552785 [PubMed - in process] (Source: Shanghai Journal of Stomatology)

CLINDAMYCIN (Clindamycin Phosphate) Injection, Solution [Hospira, Inc.]

Updated Date: Jan 23, 2013 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

EVOCLIN (Clindamycin Phosphate) Aerosol, Foam [Stiefel Laboratories Inc]

Updated Date: Jan 9, 2013 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

High prevalence of fluoroquinolone-resistant group B streptococci among clinical isolates in China: predominance of ST19 with serotype III.

Authors: Wang H, Zhao C, He W, Zhang F, Zhang L, Cao B, Sun Z, Xu Y, Yang Q, Mei Y, Hu B, Chu Y, Liao K, Yu Y, Hu Z, Ni Y Abstract A total of 146 Group B Streptococcus isolates from 8 cities across China belonged to four serotypes. Serotype Ia was more common in children. High prevalence of resistance was observed for levofloxacin (37.7%), erythromycin (71.2%), clindamycin (54.1%), and tetracycline (81.5%). The levofloxacin and clindamycin resistances among the 4 serotypes differed significantly. Eighty percent of fluoroquinolone-resistant isolates belonged to ST19/serotype III clone with GyrA-ParC-ParE triple substitutions. This clone carried erm(B), mef(E), and tet(M) genes. PMID: 23295933 [PubMed - as supplied by publisher] (Source: Antimicrobial Agents and Chemotherapy)<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>

CLINDAMYCIN HYDROCHLORIDEcapsule [PD-Rx Pharmaceuticals, Inc.]

Updated Date: Jan 2, 2013 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

Fluoroquinolones and Ocular MRSA Infections

We read with great interest and appreciation the paper ‚??Methicillin-Resistant Staphylococcus aureus Ocular Infection: A 10-Year Hospital-Based Study‚?Ě by Hsiao et al. In their study, Staphylococcus aureus was isolated from 519 patients with ocular infections, 274 (52.8%) of which had methicillin-resistant S aureus (MRSA) infections. No difference in gender distribution was identified (male:female = 138:136) in these MRSA patients. Both community-associated (CA) and healthcare-associated (HA) MRSA isolates were resistant to clindamycin and erythromycin, but CA-MRSA was more susceptible to sulfamethoxazole/trimethoprim. Unfortunately, the study lacks information on the in vitro susceptibility of ocular MRSA infections to fluoroquinolones. (Source: Ophthalmology)

Perrigo Company Acquires Remaining Stake In Cobrek Pharmaceuticals, Inc. For Approximately $45 Million

-- Solidifies Perrigo's leadership position in topical foam-based generic prescription pharmaceuticals -- Concludes 4+ year collaborative partnership responsible for successful launches of generic versions of Evoclin&#174; (clindamycin phosphate)... (Source: Drugs.com - Pharma News)

Perrigo Company Acquires Remaining Stake in Cobrek Pharmaceuticals, Inc. for Approximately $45 Million

Solidifies Perrigo's leadership position in topical foam-based generic prescription pharmaceuticals Concludes 4+ year collaborative partnership responsible for successful launches of generic versions of Evoclin&reg; (clindamycin phosphate) Foam 1% and E... Biopharmaceuticals, Generics, Mergers & AcquisitionsPerrigo Company, Cobrek Pharmaceuticals (Source: HSMN NewsFeed)

In vitro antibiotic susceptibility patterns of Propionibacterium acnes isolated from acne patients: an Egyptian university hospital‚?źbased study

Conclusion‚?? Propionibacterium acnes in vitro susceptibility patterns differed among Egyptian patients to the commonly prescribed antibiotics with the highest to lowest resistance to clindamycin, erythromycin, oxytetracycline, doxycycline and azithromycin. (Source: Journal of the European Academy of Dermatology and Venereology)<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>

CLINDAMYCIN - BENZOYL PEROXIDE (Clindamycin Phosphate And Benzoyl Peroxide) Gel [Prasco Laboratories]

Updated Date: Dec 13, 2012 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

DUAC (Clindamycin Phosphate And Benzoyl Peroxide) Gel [Stiefel Laboratories Inc]

Updated Date: Dec 12, 2012 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

Clindamycin: Neutropenia: case report

(Source: Reactions)

In Vivo Bioluminescence Imaging to Evaluate Systemic and Topical Antibiotics against Community-Acquired Methicillin-Resistant Staphylococcus aureus-Infected Skin Wounds in Mice.

Authors: Guo Y, Ramos RI, Cho JS, Donegan NP, Cheung AL, Miller LS Abstract Community-acquired methicillin-resistant Staphylococcus aureus (CA-MRSA) frequently causes skin and soft-tissue infections, including impetigo, cellulitis, folliculitis, and infected wounds and ulcers. Uncomplicated CA-MRSA skin infections are typically managed in an outpatient setting with oral and topical antibiotics and/or incision and drainage whereas complicated skin infections often require hospitalization, intravenous antibiotics, and sometimes surgery. The aim of this study was to develop a mouse model of CA-MRSA wound infection to compare the efficacy of commonly used systemic and topical antibiotics. A bioluminescent USA300 CA-MRSA strain was inoculated into full-thickness scalpel wounds on the ba...

Group A Streptococcus Toxic Shock Syndrome: An outbreak report and review of the literature

Highlights: ‚?ļ Invasive GAS TSS is a serious disease with a high case fatality rate; an ongoing health challenge. ‚?ļ Early implementation of infection control measures is very crucial in the successful management and control of this outbreak. ‚?ļ Infection control investigations should start after the identification of the first case. ‚?ļ Mode of GAS transmission needs further studies. ‚?ļ The first report on GAS Toxic Shock Syndrome in Qatar.Summary: Group A Streptococcal (GAS) Toxic Shock Syndrome (TSS) is an acute, rapidly progressive, and often fatal illness. Outbreaks can occur in hospitals. However, early infection control measures may interrupt transmissions and prevent morbidity and mortality.Two cases of invasive GAS TSS were diagnosed within 48h after two uncomplicated laparosc...<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>

Pharmacotherapy for Methicillin-Resistant Staphylococcus aureus Nosocomial Pneumonia.

CONCLUSIONS: Based on the currently available evidence and cost-effectiveness, vancomycin should continue to be the drug of choice for most patients with nosocomial MRSA pneumonia. Linezolid is a reasonable alternative for patients with treatment failure while receiving vancomycin, isolates with vancomycin minimum inhibitory concentrations over 2 őľg/mL, allergic reactions, or vancomycin-induced nephrotoxicity. PMID: 23232021 [PubMed - in process] (Source: The Annals of Pharmacotherapy)

Resistance of Bacteroides isolates recovered among clinical samples from a major Costa Rican hospital between 2000 and 2008 to √?-lactams, clindamycin, metronidazole, and chloramphenicol.

Conclusions. The high MIC for clindamycin obtained for the majority of the resistant strains is highly suggestive of the presence of mechanisms of acquired resistance among the isolates, therefore surveillance studies are required to determine its efficacy. The low resistance to metronidazole observed underlines its value as a first-line drug. On the other hand, imipenem could be used to treat infections that do not respond well to metronidazole or clindamycin. PMID: 23303257 [PubMed - in process] (Source: Revista Espanola de Quimioterapia)

The effect of calcium hydroxide on the antibiotic component of Odontopaste¬ģ and Ledermix¬ģ paste

ConclusionThe addition of calcium hydroxide to Odontopaste¬ģ or Ledermix¬ģ Paste results in reductions of the respective antibiotic over a 7‚?źday time period. (Source: International Endodontic Journal)

The tolerability profile of clindamycin 1%/benzoyl peroxide 5% gel vs. adapalene 0.1%/benzoyl peroxide 2.5% gel for facial acne: results of a randomized, single‚?źblind, split‚?źface study

ConclusionsClindamycin/BPO had a better tolerability profile than adapalene/BPO during 2¬†weeks of split‚?źface treatment. Treatment satisfaction was highest with clindamycin/BPO. (Source: Journal of Cosmetic Dermatology)

CLINDAMYCIN HYDROCHLORIDEcapsule [Watson Laboratories, Inc.]

Updated Date: Nov 14, 2012 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>

Population pharmacokinetics of clindamycin orally and intravenously administered in patients with osteomyelitis

CONCLUSIONS The current recommendation of 600‚??mg three times daily seems to be effective up to 75‚??kg but the dose should be raised to 900‚??mg three times daily thereafter. These assumptions should be prospectively confirmed. (Source: British Journal of Clinical Pharmacology)

Antimicrobial susceptibility and resistance mechanisms of clinical Clostridium difficile from a Chinese tertiary hospital

Abstract: Clostridium difficile is a predominant cause of antibiotic-associated diarrhoea. It is increasingly difficult to treat C. difficile infection efficiently owing to its multidrug resistance. In the present study, 60 clinical C. difficile isolates were collected and analysed for their genotype, antimicrobial susceptibility and resistance mechanisms. Tandem repeat sequence typing (TRST) generated 21 types, including the epidemic clone tr017. Antimicrobial susceptibility testing of eight antibiotics was performed by the agar dilution method. Rifampicin, metronidazole and vancomycin remained the most potent agents in vitro, whilst the resistance rates of other agents such as ciprofloxacin, cefoxitin, clindamycin, tetracycline and moxifloxacin varied from 30% to 100%. 73.33% of the stra...

Nationwide surveillance of antimicrobial susceptibility patterns of pathogens isolated from surgical site infections (SSI) in Japan

Abstract&nbsp;&nbsp;To investigate the trends of antimicrobial resistance in pathogens isolated from surgical site infections (SSI), a Japanese surveillance committee conducted the first nationwide survey. Seven main organisms were collected from SSI at 27 medical centers in 2010 and were shipped to a central laboratory for antimicrobial susceptibility testing. A total of 702 isolates from 586 patients with SSI were included. Staphylococcus aureus (20.4&nbsp;%) and Enterococcus faecalis (19.5&nbsp;%) were the most common isolates, followed by Pseudomonas aeruginosa (15.4&nbsp;%) and Bacteroides fragilis group (15.4&nbsp;%). Methicillin-resistant S. aureus among S. aureus was 72.0&nbsp;%. Vancomycin MIC 2&nbsp;őľg/ml strains accounted for 9.7&nbsp;%. In Escherichia coli, 11 of 95 strains...

The newly described mecA homologue, mecALGA251, is present in methicillin-resistant Staphylococcus aureus isolates from a diverse range of host species

Conclusions The discovery of MRSA isolates possessing mecALGA251 from a diverse range of host species, including different taxonomic classes, has important implications for the diagnosis of MRSA in these species and our understanding of the epidemiology of this novel mecA homologue. (Source: Journal of Antimicrobial Chemotherapy)

Oritavancin does not induce Clostridium difficile germination and toxin production in hamsters or a human gut model

Conclusions Oritavancin exposure, unlike exposure to vancomycin or clindamycin, did not lead to CDI in hamsters. In both models, oritavancin reduced C. difficile total counts and spores to below detectable limits. The data indicate the potential of oritavancin for CDI treatment, since exposure did not induce C. difficile germination and toxin production, which are known to exacerbate the disease state. (Source: Journal of Antimicrobial Chemotherapy)<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>

An evaluation of the impact of antibiotic stewardship on reducing the use of high-risk antibiotics and its effect on the incidence of Clostridium difficile infection in hospital settings

Conclusions The restriction of the high-risk antibiotics contributed to both a reduction in their use and a reduction in the incidence of CDI in the study site hospital. Time-series analysis can be utilized as a risk classification tool with utility in antibiotic stewardship design and quality improvement programmes. (Source: Journal of Antimicrobial Chemotherapy)

[Management of post-partum infections.]

Authors: Lamy C, Zuily S, Perdriolle E, Gauchotte E, Villeroy-de-Galhau S, Delaporte MO, Wahl D, Morel O, Judlin P Abstract Post-partum endometritis are frequent and account for the fifth cause of maternal death. This disease is preventable and effective treatments are available. Streptococcus agalactiae is the primary pathogen implicated. The clinical diagnosis is usually easy and involves pelvic pain, fever and abnormal lochia. Whenever antibiotic treatment provides no clinical improvement, or in case of doubt on the vacuity of the uterus, an ultrasound exam must be performed. Likewise, a CT scan or a MRI will be performed in case of persistent fever in search of a pelvic abscess requiring a drainage, or of a pelvic thrombophlebitis. Thromboplebitis requires heparin for the durat...

Methicillin‚?źresistant Staphylococcus aureus keratitis in a dog

Abstract The purpose of this study is to report a case of methicillin‚?źresistant Staphylococcus aureus (MRSA) keratitis in a dog. A 7‚?źyear‚?źold intact male American cocker spaniel that had undergone removal of a nictitating gland was referred for severe ulcerative keratitis. Slit‚?źlamp examination showed swelling of the eyelid, mucopurulent discharge, conjunctival injection and chemosis, diffuse corneal edema and opacity, and a deep ulcer in central cornea. Gram staining of discharge from the eye demonstrated Gram‚?źpositive cocci. Despite topical ofloxacin, oxytetracycline and polymyxin B ophthalmic solution and intravenous cefazolin, there was no improvement. Cultures revealed MRSA that was sensitive only to chloramphenicol, vancomycin, lincomycin, and clindamycin. The antibiotic re...

Phenotypic and molecular characterization of Staphylococcus aureus recovered from different clinical specimens of inpatients at a teaching hospital in Shanghai between 2005 and 2010.

This study aimed to investigate the molecular profile, including its dynamic changes and genotype-phenotype correlation of S. aureus isolates recovered from different clinical specimens of inpatients with S .aureus infection over a six-year span at a teaching hospital in Shanghai, China. Between 2005 and 2010, random sample of 610 unique S. aureus isolates were collected from different clinical samples of inpatients with S. aureus infection for molecular and antibiotic susceptibility analysis. Our results showed that among the 610 S. aureus isolates, 20 MLST sequence types (STs; primarily ST239, ST5, ST7, ST188, and ST398) and 52 spa types (primarily t002, t037, t030, and t601) were found. In total, 444 isolates (72.8%) were MRSA and 166 (27.2%) were MSSA. The ST239-MRSA-III-spa t037 and S...

Soft Tissue Infection Caused by Burkholderia cepacia in a Child with Polyarteritis Nodosa.

Authors: YńĪldńĪz B, Duyu M, S√∂zeri B, KarapńĪnar B Abstract Burkholderia cepacia belongs to a family of Burkholderia species previously described as Pseudomonas cepacia, especially in patients suffering from cystic fibrosis. There are also many studies about this agent in the last decade due to their life-threatening infections and ability to invade mucosal and cellular surfaces. Here, we report a case of soft tissue infection caused by B. cepacia in a child with an underlying condition of polyarteritis nodosa. Her complaints started at two months of age and she was on cyclosporine therapy. She was treated several times because of soft tissue infections especially in her extremities. The most common causative agents were Pseudomonas spp. and Escherichia coli, but recently, anothe...<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>

Clindamycin: Wrist monoarthritis in an elderly patient: case report

(Source: Reactions)

CLINDAMYCIN PALMITATE HYDROCHLORIDE (PEDIATRIC) (Clindamycin Palmitate Hydrochloride) Granule, For Solution [Rising Pharmaceuticals, Inc.]

Updated Date: Oct 31, 2012 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

CLEOCIN PHOSPHATE (Clindamycin Phosphate) Injection, Solution [General Injectables Vaccines, Inc]

Updated Date: Oct 31, 2012 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

High diversity of genetic lineages and virulence genes in nasal Staphylococcus aureus isolates from donkeys destined to food consumption in Tunisia with predominance of the ruminant associated CC133 lineage

Conclusions: The nares of donkeys frequently harbor MSSA. They could be reservoirs of the ruminant-associated CC133 lineage and of toxin genes encoding TSST-1 and other virulence traits with potential implications in public health. CC133 seems to have a broader host distribution than expected. (Source: BMC Veterinary Research - Latest articles)

Addressing Antimicrobial Resistance to Treat Children With Atopic Dermatitis in a Tertiary Pediatric Allergy Clinic

Conclusions. Susceptibility profiles of S aureus isolates from AD patients vary significantly from that of the general population. (Source: Clinical Pediatrics)<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>

CLINDAMYCIN HYDROCHLORIDEcapsule [PD-Rx Pharmaceuticals, Inc.]

Updated Date: Oct 23, 2012 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

10-year-old Female With a Subglottic Mass

[Ann Emerg Med. 2012;60:668.] A 10-year-old girl presented to the emergency department (ED) with a growing neck mass for the past several weeks. The mother stated that the patient had a sublingual mass around 15 days before being treated in the ED. The mother took her child to the nearest ED, where she was discharged with amoxicillin. The mass kept growing and was expanding under the left side of her jaw (). She was taken to a hospital in San Antonio, where she received intravenous clindamycin and was observed for 7 days. During this admission, radiographs were taken but the mother was unsure of the result. The patient was discharged receiving clindamycin and a steroid taper. After discharge, the mass kept expanding, so the mother decided to bring the patient to the ED. The child had not ...

Characterization of methicillin-resistant Staphylococcus aureus from skin and soft tissue infections in patients in Nairobi, Kenya

Conclusions: These findings suggest that SCCmec II MRSA and a PVL strain of MRSA are significant pathogens in patients with SSTIs presenting to hospitals in Kenya, and that MRSA cases are prevalent at publicly funded health care facilities. (Source: International Journal of Infectious Diseases)

Clindamycin: Ageusia, xerostomia and burning mouth syndrome: case report

(Source: Reactions)

Evolution of Helicobacter pylori susceptibility to antibiotics during a 10‚?źyear period in Lithuania

The study evaluated the changes in the prevalence of Helicobacter pylori strains with primary resistance to antibiotics during the last 10¬†years in Lithuania. H. pylori susceptibilities to antibiotics were tested in 89 patients in 1998, in 81 patients in 2001 and in 90 patients in 2007/2008. Susceptibility to metronidazole, clarithromycin, amoxicillin and tetracycline was tested using E‚?źtest or agar dilution method. Susceptibility to ciprofloxacin was only tested in 2007/2008. Data about utilization of all authorized and available on market macrolides and clindamycin in Lithuania during 2003‚??2007 were evaluated using WHO ATC/DDD methodology. A total of 260 H. pylori strains cultured from untreated adult patients were investigated. Primary resistance rates (1998, 2001 and 2007/2008) fo...<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>

CLINDAMYCIN PHOSPHATE AND BENZOYL PEROXIDEkit [Mylan Pharmaceuticals Inc.]

Updated Date: Oct 18, 2012 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

Comment: Probable Clindamycin-Induced Ageusia, Xerostomia, and Burning Mouth Syndrome (November).

Authors: Fortuna G, Pollio A PMID: 23073308 [PubMed - as supplied by publisher] (Source: The Annals of Pharmacotherapy)

Clindamycin: Hyperphosphataemia (first report) in a child: case report

(Source: Reactions)

CLEOCIN HYDROCHLORIDE (Clindamycin Hydrochloride) Capsule [Pharmacia And Upjohn Company]

Updated Date: Oct 10, 2012 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

CLINDAMYCIN PALMITATE HYDROCHLORIDE (PEDIATRIC) (Clindamycin Palmitate Hydrochloride) Granule, For Solution [Lyne Laboratories, Inc.]

Updated Date: Oct 2, 2012 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>

Antibiotic Exposure and IBD Development Among Children: A Population-Based Cohort Study

CONCLUSIONS: Childhood antianaerobic antibiotic exposure is associated with IBD development. (Source: PEDIATRICS)

[Probiotics for the Prevention of Antibiotic-induced Diarrhea].

Authors: Eser A, Thalhammer F, Burghuber F, H√∂genauer C, Stockenhuber F, Wenisch C, Widhalm K, Reinisch W Abstract Between 5 and 49‚??% of patients treated with antibiotics suffer from diarrhoea. Principally all microbial agents can cause diarrhoea, especially oral agents like cephalosporines, clindamycin, broad-spectrum penicillins, and quinolones of the 3‚??rd and 4th generation. Manifestations of antibiotic-associated diarrhoea range from mild self-limiting forms to severe life-threatening courses. The potentially most severe form of antibiotic-associated diarrhoea is caused by Clostridium diffcile accounting for approx. 25‚??% of antibiotic-associated diarrhoea. In the past two decades a broad spectrum of different probiotic strains has been evaluated for the primary preventio...

A comparative study of amoxicillin, clindamycin and chlorhexidine in the prevention of post-extraction bacteraemia.

Authors: Maharaj B, Coovadia Y, Vayej AC Abstract We evaluated some of the regimens recommended for the antimicrobial prophylaxis of infective endocarditis prior to dental extraction in 160 patients. Group A patients served as the control group, group B subjects rinsed their mouths with chlorhexidene, group C subjects took 3 g amoxicillin orally and group D patients took 600 mg clindamycin orally. The proportion of patients who had post-extraction bacteraemia in groups A, B, C and D was 35, 40, 7.5 and 20%, respectively. The differences between the control and amoxicillin groups (p = 0.003) and between the chlorhexidine and amoxicillin groups (p = 0.0006) were statistically significant. Streptococci were not isolated in any patients in the amoxicillin and clindamycin groups. In our...

Antimicrobial susceptibility and molecular subtypes of Staphylococcus aureus isolated from pig tonsils and cow's milk in China.

This study investigated and compared the antimicrobial resistance patterns and ribotypes of Staphylococcus aureus isolated from pig tonsils and cow's milk in China. A total of 90 isolates of S. aureus was included: 42 strains were isolated from tonsils of pigs and 48 from half-udder milk. The broth microdilution method and the double-disc diffusion test (D test) were used for antimicrobial susceptibility testing. The mecA gene for methicillin-resistant S. aureus (MRSA) and the ermA, ermB, ermC, and msrA genes for erythromycin-resistant strains were detected by polymerase chain reaction (PCR). The isolates were ribotyped with the Riboprinter system. The highest frequency of resistance was observed with clindamycin (91.1%), followed by penicillin (90.0%), and erythromycin (85.6%). All strain...

Intravitreal clindamycin plus dexamethasone versus classic oral therapy in toxoplasmic retinochoroiditis: a prospective randomized clinical trial

In conclusion, both IVCD and COT are equally effective against active toxoplasmic retinochoroiditis but the former is apparently safer and more convenient. Content Type Journal ArticleCategory Original PaperPages 1-8DOI 10.1007/s10792-012-9634-1Authors Nader Baharivand, Nikookari Eye Hospital, Tabriz University of Medical Sciences, Tabriz, IranAli Mahdavifard, Nikookari Eye Hospital, Tabriz University of Medical Sciences, Tabriz, IranRohollah Fadaei Fouladi, Medical Faculty, Tabriz University of Medical Sciences, Golgasht, Tabriz, Iran Journal International OphthalmologyOnline ISSN 1573-2630Print ISSN 0165-5701 (Source: International Ophthalmology)<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>

Genetic characterization of Panton-Valentine leukocidin-producing methicillin-resistant Staphylococcus aureus in Western Austria.

CONCLUSIONS: The major lukS-lukF-positive MRSA lineage found in our population was ST8, t008 and positive for arcA which is mainly found in the USA. In contrast, ST80 strains were not found as frequently in our region as in many other European countries. PMID: 23053569 [PubMed - as supplied by publisher] (Source: Wiener Klinische Wochenschrift)

Morphological, biochemical, physiological and molecular aspects of the response of Fusobacterium nucleatum exposed to subinhibitory concentrations of antimicrobials.

Authors: de Souza Filho JA, Diniz CG, Barbosa NB, de Freitas MC, Lopes Neves MS, da Gama Mazzei RN, Coelho CM, da Silva VL Abstract Subinhibitory concentrations (SICs) of antimicrobials may result in alterations in bacterial biology with implications for its potential aggression. This has considerable importance for the resident microbiota. Our aim was to analyze the effects of SICs of antimicrobials on the morphological, biochemical, physiological and molecular characteristics of the resident anaerobic Fusobacterium nucleatum. Fourteen strains were obtained from F. nucleatum ATCC 25586, selected by culturing on SICs of ampicillin, ampicillin/sulbactam, clindamycin, chloramphenicol, levofloxacin, metronidazole and piperacillin/tazobactam and subsequent culturing in the absence of ...

CLINDAMYCIN HYDROCHLORIDEcapsule [Mylan Institutional Inc.]

Updated Date: Sep 26, 2012 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

Diversity in the antimicrobial susceptibility patterns of methicillin-resistant Staphylococcus aureus clones

Abstract&nbsp;&nbsp;Methicillin-resistant Staphylococcus aureus (MRSA) is well known for its epidemicity, with the emergence of new clones on a daily basis. Diversity in the clonal types of MRSA challenges the success of treatment, as different clones respond to different sets of antibiotics. However, the antibiotic susceptibility among the isolates within the same clones is largely unexplored. In a previous study on MRSA epidemiology in Malaysia, we identified six major clonal complexes (ST-239-CC8, ST-1-CC1, ST-188-CC1, ST-22-CC22, ST-7-CC7 and ST-1283-CC8). In the present study, we investigated the antibiotic susceptibility patterns of isolates of different clones. Three hundred and eighty-nine MRSA isolates were subjected to the disc diffusion test, oxacillin minimum inhibitory co...

Emergence of Multiresistant Methicillin‚?źResistant Staphylococcus aureus in Two Patients with Atopic Dermatitis Requiring Linezolid Treatment

We report two patients with atopic dermatitis who developed methicillin‚?źresistant Staphylococcus aureus (MRSA) skin infections resistant to clindamycin and trimethoprim‚?źsulfamethoxazole requiring repeated linezolid treatment. For one patient and family members who received an aggressive regimen of staphylococcal decolonization, including intranasal mupirocin, dilute bleach baths, and bleach cleansing of household items and surfaces, subsequent culture results demonstrated methicillin‚?źsusceptible S. aureus colonization and infection. These findings underscore the challenges presented by multiresistant MRSA infections in children with atopic dermatitis. (Source: Pediatric Dermatology)<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>

Antibacterial therapeutics for the treatment of chytrid infection in amphibians: Columbus's egg?

Conclusions: We thus conclude that, despite marked anti B. dendrobatidis activity in vitro, the florfenicol treatment used is not capable of eliminating B. dendrobatidis infections from amphibians. (Source: BMC Veterinary Research - Latest articles)

Increased Incidence of Skin and Soft Tissue Infections and Associated Antimicrobial Use: A Population-Based Study.

Conclusion: Health care utilization and antibiotic prescribing rates for SSTI, but not I&D procedures, have increased in association with the CA-MRSA epidemic. While much of the increase in antibiotic use reflects an appropriate change to trimethoprim-sulfamethoxazole, there is room for education around the limitations of cephalosporins and clindamycin, given current susceptibility profiles. PMID: 23006762 [PubMed - as supplied by publisher] (Source: Antimicrobial Agents and Chemotherapy)

Effectiveness of a short (4 day) course of oritavancin in the treatment of simulated Clostridium difficile infection using a human gut model

Conclusions Shortened courses of oritavancin and vancomycin effectively treated CDI in a human gut model, but evidence of recurrence was observed following vancomycin instillation. Oritavancin exposure inhibited the recovery of C. difficile spores, as previously described. Shortened antibiotic exposure minimizes disruption to the gut microflora. These data indicate the possible value of a 4 day oritavancin dosing regimen for CDI treatment. (Source: Journal of Antimicrobial Chemotherapy)

Molecular epidemiology of methicillin-resistant Staphylococcus aureus in a Spanish hospital over a 4-year period: clonal replacement, decreased antimicrobial resistance, and identification of community-acquired and livestock-associated clones

This study was carried out on 189 methicillin-resistant Staphylococcus aureus (MRSA) clinical isolates collected in a third-level hospital in Valladolid, Spain, between 2005 and 2008 in order to investigate the changes in molecular epidemiology and genetic backgrounds associated with the changes in resistance phenotypes produced over time. The MRSA isolates were classified as belonging to 10 different clones, including the identification of a novel MRSA clone, ST2422-MRSA-IV, belonging to CC121; 1 CA-MRSA strain from a USA300 clone; another from ST97-MRSA-IV, associated with clones adapted to livestock (LA-MRSA); and 2 strains belonging to a new spa type (t10258) related to the ST8-MRSA-IV clone. Sixty-two percent of the strains belonging to Spanish-prevalent MRSA sequence type ST125 harbo...

Preoperative Antibiotic Prophylaxis in the Penicillin-Allergic Patient

Because of their efficacy against these gram-positive cocci, cephalosporin antibiotics are commonly used as first-line prophylaxis against surgical site infection (SSI). Although this antibiotic class is largely effective, some thought must be given to situations in which cephalosporins cannot be used. Furthermore, picking an alternative to cephalosporins becomes relevant clinically because of a substantial cost difference between 2 commonly available choices. This review attempts to highlight the issues involved in the decision-making process between 2 commonly used antistaphylococcal agents: intravenous clindamycin and intravenous vancomycin. (Source: The Journal of Hand Surgery)<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>

Updated national IV monograph on Clindamycin

Source: Medusa Area: News An updated&#160;IV&#160;monograph on Clindamycin is now available from the NHS injectable medicines guide website (Medusa). Please see the link below for access (registration required). &#160; (Source: NeLM - News)

Changing microbiology of pediatric neck abscesses in iowa 2000‚??2010

Conclusions:These findings demonstrate a statistically significant rise in the proportion of MRSA neck infections in pediatric patients in Iowa. Resistance to clindamycin was highest among MSSA isolates. Clindamycin‚?źresistant S. aureus and Streptococcus pyogenes are established pathogens in neck infections. In communities with similar microbiology patterns, empiric treatment with combination therapy of a beta lactam and vancomycin or trimethoprim/sulfamethoxazole should be initiated until culture results are available. (Source: The Laryngoscope)

Clindamycin-induced neutropenia following major head and neck surgery.

Authors: Schmidt RS, Reiter ER Abstract A 64-year-old man undergoing major head and neck surgery received clindamycin for perioperative antimicrobial prophylaxis. On the third postoperative day, he became acutely neutropenic. The neutropenia resolved 3 days later, after the administration of filgrastim. After ruling out other causes of acute neutropenia, we determined that the neutropenia was secondary to clindamycin toxicity. While clindamycin-induced neutropenia has been reported elsewhere, to our knowledge this is the first report of its occurrence following head and neck surgery. Otolaryngologists should be aware of this potentially serious reaction. PMID: 22996716 [PubMed - in process] (Source: Ear, Nose and Throat Journal)

Antimicrobial susceptibility, characterization of bacitracin operon and bacitracin biosynthesis of Bacillus spp. strains isolated from primary starters for African traditional bread production.

Authors: Adimpong DB, S√łrensen KI, Thorsen L, Stuer-Lauridsen B, Abdelgadir WS, Nielsen DS, Derkx PM, Jespersen L Abstract Bacillus spp. are widely used feed additives and probiotics. However, there is limited information on their resistance towards various antibiotics, and a growing concern of transfer of antibiotic-resistance genes. The minimum inhibitory concentration (MIC) for 8 antibiotics was determined for 85 Bacillus spp. strains; Bacillus subtilis subsp. subtilis (n=29), Bacillus licheniformis (n=38) and Bacillus sonorensis (n=18), all isolated from starters for Sudanese bread production. All the strains were sensitive to tetracycline (8.0 mg/L), vancomycin (4.0 mg/L) and gentamicin (4.0 mg/L) but resistant to streptomycin. Sensitivity to clindamycin, chloramphenicol and ...

Med Sci Monit 2012; 18(9):BR356-361 &quot;Bacterial superinfection in Zoonotic Cutaneous Leishmaniasis&quot;

Conclusions: Bacterial superinfection appears to be very common in ZCL, but its prevalence is not different from that of non-ZCL lesions and it has little effect on the clinical appearance of anthroponotic cutaneous Leishmaniasis (ACL). Local lesion care and management of bacterial superinfection must be considered in the treatment of ZCL. (Source: Medical Science Monitor)<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>

Antibiogram testing of pediatric skin infections in the era of methicillin‚?źresistant Staphylococci aureus: an Egyptian University Hospital‚?źbased study

Conclusions‚?? CA‚?źMRSA skin infections are not common among Egyptian children and, therefore, beta‚?źlactams are still effective empiric antimicrobial therapy for most infections. Antibiogram testing from suppurative skin lesions are, however, better to be recommended to guide individual therapy. Clindamycin should not be considered for susceptible isolates unless they are erythromycin susceptible or D‚?źtest negative. (Source: International Journal of Dermatology)

Rescreening for abnormal vaginal flora in pregnancy and re-treating with clindamycin vaginal cream significantly increases cure and improvement rates

We investigated 199 pregnant women with bacterial vaginosis (BV) who received clindamycin vaginal cream (CVC) for three days and compared with 205 women treated with placebo. The vaginal flora was assessed at each visit. At the second visit, 71% in the CVC group were cured/improved, compared with 12% in the placebo group (P &lt; 0.001). At visit 3 about 90% who responded to initial CVC treatment were still cured/improved. Of women who initially failed to respond to CVC and were given an additional seven-day course, 33% were cured/improved by the third visit, compared with 15% who failed to respond to placebo initially and were given a further seven-day course (P = 0.02). By visit 4, half the women in the CVC group who received additional treatment remained cured/improved, compared with 26%...

CLINDAMYCIN PHOSPHATEgel [Lake Erie Medical DBA Quality Care Products LLC]

Updated Date: Aug 27, 2012 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

CLINDAMYCIN PHOSPHATE AND BENZOYL PEROXIDE (Clindamycin, Benzoyl Peroxide) Gel [Perrigo New York Inc]

Updated Date: Aug 27, 2012 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

Ante-Mortem Diagnosis, Diarrhea, Oocyst Shedding, Treatment, Isolation and Genetic Typing of Toxoplasma gondii Associated with Clinical Toxoplasmosis in a Naturally Infected Cat.

Authors: Dubey JP, Prowell M Abstract Abstract Toxoplasma gondii infections are common in humans and other animals but clinical disease is relatively rare. It is unknown whether the severity of toxoplasmosis in immunocompetent hosts is due to the parasite strain, host variability, or to other factors. Recently, attention has been focused on the genetic variability among T. gondii isolates from apparently healthy and sick hosts. Whether T. gondii genetic makeup plays a part in the pathogenesis of clinical feline toxoplasmosis is uncertain because little is known of genetic typing of strains associated with clinical feline toxoplasmosis. A 6- mo-old domestic male cat was hospitalized with because of lethargy, anorexia, fever, and diarrhea. Numerous (6 million in 1 sample) T. gondii ...<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>

Severe sepsis and septic shock in pregnancy.

Authors: Barton JR, Sibai BM Abstract Pregnancies complicated by severe sepsis and septic shock are associated with increased rates of preterm labor, fetal infection, and preterm delivery. Sepsis onset in pregnancy can be insidious, and patients may appear deceptively well before rapidly deteriorating with the development of septic shock, multiple organ dysfunction syndrome, or death. The outcome and survivability in severe sepsis and septic shock in pregnancy are improved with early detection, prompt recognition of the source of infection, and targeted therapy. This improvement can be achieved by formulating a stepwise approach that consists of early provision of time-sensitive interventions such as: aggressive hydration (20 mL/kg of normal saline over the first hour), initiation ...

[Systemic and local antibiotic therapy of conservative and operative treatment of spondylodiscitis.]

Authors: Fleege C, Wichelhaus TA, Rauschmann M Abstract An evidence-based recommendation for a standardized antibiotic therapy of spondylodiscitis has not yet been published. Crucial for conservative therapy is the verification of the causative organism and an appropriate antibiotic therapy. Intravenous antibiotic therapy should be administered for 2-3 weeks and a switched to oral administration for 6-12 weeks is then possible. If an empirical antimicrobial therapy is required a combination of ciprofloxacin and clindamycin, alternatively a combination of cefotaxim and flucloxacillin is recommended. Surgical removal of the infection by extensive debridement with stabilization and filling the resulting bone defect is desirable. Under the perception of a high local dose of antibiotic ...

Risk factors for development of Clostridium difficile infection due to BI/NAP1/027 strain: a meta-analysis

Conclusions: Fluoroquinolones and age over 65 years were associated with a higher risk of CDI due to the BI/NAP1/027 strain. Clindamycin was associated with a lower risk of CDI due to BI/NAP1/027. (Source: International Journal of Infectious Diseases)

Neonatal methicillin-resistant Staphylococcus aureus (MRSA) suppurative head and neck infections

We describe two cases at the Children's Hospital of Philadelphia of neonates requiring surgical drainage of head and neck infections. The patients consisted of 2 males, presenting 9 and 13 days of life, respectively. Both were born via Caesarean section and were full-term deliveries without any identifiable, high-risk obstetrical issues. The infection sites were submandibular and orbital. Both of the patients grew wound cultures positive for methicillin-resistant Staphylococcus aureus (MRSA), which were both sensitive to bactrim (trimetroprim-sulfamethoxazole) and in one case, resistant to clindamycin. Fevers in the neonatal period (age (Source: International Journal of Pediatric Otorhinolaryngology Extra)

Antibiotic regimens for the empirical treatment of newborn infants with necrotising enterocolitis.

CONCLUSIONS: There was insufficient evidence to recommend a particular antibiotic regimen for the treatment of NEC. There were concerns about adverse effects following the usage of clindamycin, related to the development of strictures. To address this issue a large randomised controlled trial needs to be performed. PMID: 22895960 [PubMed - in process] (Source: Cochrane Database of Systematic Reviews)<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>

Multidrug‚?źresistant coagulase‚?źnegative Staphylococci in food animals

ConclusionsMultidrug resistance and resistance to non‚?źő≤‚?źlactam antimicrobials are common in CoNS in animals. Significance and Impact of the StudyThe data improve our understanding on the extent to which CoNS contribute to the dissemination of antimicrobial resistance in the food production environment. (Source: Journal of Applied Microbiology)

Recurrent menstrual toxic shock syndrome despite discontinuation of tampon use: Is menstrual toxic shock syndrome really caused by tampons?

We present a case of recurrent MTSS initially associated with tampon use that continued to recur when tampons were discontinued, which was successfully treated with rifampicin and clindamycin. (Source: Australasian Journal of Dermatology)

Occurrence and Antimicrobial Susceptibility of Listeria monocytogenes Isolated from Brined White Cheese in Jordan

Abstract:‚?? Listeria monocytogenes is a serious foodborne pathogen that has been isolated from different dairy food products. Several foodborne outbreaks of listeriosis have been associated with consumption of cheese. The aims of this study were to determine the occurrence of L. monocytogenes and Listeria spp. in brined white cheese (BWC) sold in Jordan, and to determine the susceptibility of isolated L. monocytogenes to antimicrobials. Three hundred and fifty samples of 5 different types of BWC (akkawi, boiled, halloumi, pasteurized, and shellal) were collected from a local market in Jordan. The ISO (11290‚?ź1) procedure was followed for isolation and identification of Listeria spp. from cheese samples and a polymerase chain reaction (PCR) technique was used for confirmation of L. monocy...

CLINDAMYCIN PHOSPHATEcream [Greenstone LLC]

Updated Date: Aug 15, 2012 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>

Antibiotic susceptibility profiles of oral pathogens

Abstract: Periodontitis is a bacterial disease that can be treated with systemic antibiotics. The aim of this study was to establish the antibiotic susceptibility profiles of five periodontal pathogens to six commonly used antibiotics in periodontics. A total of 247 periodontal bacterial isolates were tested for susceptibility to the six antibiotics using the Etest method. MIC50 and MIC90 values (minimum inhibitory concentrations for 50% and 90% of the organisms, respectively) were calculated. Both European Committee on Antimicrobial Susceptibility Testing (EUCAST) and Clinical and Laboratory Standards Institute (CLSI) breakpoints were used in the study to interpret results. ő≤-Lactamase production was tested when amoxicillin resistance was found. MIC90 values of the anaerobic bacteria wer...

CLINDAMYCIN (Clindamycin Phosphate) Injection, Solution, Concentrate [Hospira, Inc.]

Updated Date: Aug 10, 2012 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

Spontaneous Abscess of the Anterior Abdominal Wall Caused by Clostridium perfringens Resistant to Clindamycin

Surgical Infections , Vol. 0, No. 0. (Source: Surgical Infections)

CLINDAMYCIN (Clindamycin Phosphate) Injection, Solution, Concentrate [Hospira, Inc.]

Updated Date: Aug 7, 2012 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

CLINDAMYCIN PHOSPHATEgel [Preferred Pharmaceuticals, Inc.]

Updated Date: Aug 6, 2012 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>

Clinical and microbiological characterization of Staphylococcus lugdunensis isolates obtained from clinical specimens in a hospital in China

Conclusion: Hence, even though S. lugdunensis may be yet unrecognized and undefined in China, it still might be the infrequent cause of infection and profound multi-drug resistance in the same population. (Source: BMC Microbiology - Latest articles)

Ocular toxoplasmosis: patient age and other risk factors for a severe course of disease

Conclusion Patient age was significantly correlated with lesion size and inflammatory involvement of the anterior part of the eye. Localisation of lesions is a predictor for complications. (Source: Acta Ophthalmologica)

Staphylococcal Cassette Chromosome mec type and antibiotic susceptibility profiles of vaginal and nonvaginal MRSA clinical isolates

Abstract: Methicillin-resistant Staphylococcus aureus (MRSA) causes nosocomial and community-associated infections, representing significant healthcare concerns. Limited studies have investigated cervicovaginal MRSA colonization and antibiotic susceptibility. Upon comparing clinical cervicovaginal MRSA isolates to nonvaginal isolates by Staphylococcal Cassette Chromosome mec type, presence of Panton‚??Valentine Leukocidin toxin, antibiotic susceptibility, and presence of associated resistance genes, no significant differences were observed between the anatomical sites, but were observed between our hospital- and community-associated MRSA isolates. There was a significant increase in erythromycin resistance in our vaginal MRSA isolates compared to previous vaginal MRSA reports and an increa...

CLINDAMYCIN HYDROCHLORIDEcapsule [STAT Rx USA LLC]

Updated Date: Aug 1, 2012 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

CLINDAMYCIN HYDROCHLORIDEcapsule [Unit Dose Services]

Updated Date: Aug 1, 2012 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>

CLINDAMYCIN HYDROCHLORIDEcapsule [Major Pharmaceuticals]

Updated Date: Aug 1, 2012 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

High prevalence and resistance rates to antibiotics in anaerobic bacteria in specimens from patients with chronic balanitis.

In conclusion, anaerobes were 1.6-fold more frequent in untreated symptomatic patients compared with other patients, suggesting their participation in development of chronic balanitis. GPAs were more common than GNAs. The resistance rates to amoxicillin, clindamycin, tetracycline, and levofloxacin were high. Most active agents were metronidazole and amoxicillin/clavulanate. Resistance in anaerobes varies according to sites of specimens and years of study. PMID: 22710106 [PubMed - in process] (Source: Anaerobe)

Macrolide and tetracycline resistance in clinical strains of Streptococcus agalactiae isolated in Tunisia.

Authors: Hraoui M, Boutiba-Ben Boubaker I, Rachdi M, Slim A, Ben Redjeb S Abstract Between 2007 and 2009, 226 clinical strains of Streptococcus agalactiae, recovered from female genital specimens and from gastric fluid or ear specimens from infected newborns, were isolated at the Laboratory of Microbiology of Charles Nicolle Hospital of Tunis. They were investigated to determine the prevalence of antibiotic resistance and to characterize the mechanisms of resistance to macrolide and tetracycline. All strains were susceptible to penicillin, ampicillin and quinupristin-dalfopristin. They were resistant to chloramphenicol (3.1‚??%), rifampicin (19.1‚??%), erythromycin (40‚??%) and tetracycline (97.3‚??%); 3.1‚??% were highly resistant to streptomycin and 1.3‚??% to gentamicin. Among t...

The effectiveness of systemic antimicrobial treatment in canine superficial and deep pyoderma: a systematic review.

Conclusions‚??-‚?? There is a need for greater numbers of adequately sized, blinded, randomized controlled trials evaluating systemic antimicrobial interventions for canine pyoderma. Improved differentiation between superficial and deep pyoderma in outcome reporting, outcome measure standardization and association of outcomes with causative bacterial species and their resistance patterns are required. PMID: 22734856 [PubMed - in process] (Source: Veterinary Dermatology)

Meticillin-resistant Staphylococcus pseudintermedius: clinical challenge and treatment options.

Authors: Frank LA, Loeffler A Abstract Meticillin-resistant Staphylococcus pseudintermedius (MRSP) has emerged as a major therapeutic challenge for small animal veterinarians over the past 10‚??years and continues to spread worryingly in many countries. This review focuses on the clinical aspects of MRSP infections seen in patients with skin disease and on currently available treatment options. In addition, it discusses the implications for in-contact people, other animals and the environment, because infection control strategies are likely to have a significant impact on treatment success and prevention of spread. There is currently no indication that MRSP is more virulent than meticillin-susceptible S.¬†pseudintermedius, and reported infections have mostly been treated successful...<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>

Selection of antibiotics for meticillin-resistant Staphylococcus pseudintermedius: time to revisit some old drugs?

Authors: Papich MG Abstract The aim of this review is to consider systemic therapy options for meticillin-resistant Staphylococcus pseudintermedius (MRSP). Infections caused by MRSP in small animals - particularly dogs - have been frustrating veterinarians in recent years. After a susceptibility test is performed, veterinarians are left to select from drugs that have not been frequently encountered on a susceptibility report. Some of these are old drugs that have not been used regularly by veterinary dermatologists. As MRSP is, by definition, resistant to all ő≤-lactam antibiotics, including cephalosporins, penicillins and amoxicillin-clavulanate combinations, the ő≤-lactam drugs are not an option for systemic treatment. As most MRSPs are multidrug resistant, familiar drugs, such a...

Drug-Induced Hypersensitivity Syndrome Induced by Clindamycin.

Authors: Nakamura Y, Watamatsu K, Muto M Abstract Abstract is missing (Letter). PMID: 22855006 [PubMed - as supplied by publisher] (Source: Acta Dermato-Venereologica)

[Antibiotic treatment of hidradenitis suppurativa].

Authors: Revuz J Abstract Bacterial infection plays an important role in hidradenitis suppurativa (HS). This infection has a number of unique features: chronicity, absence of lymph node involvement, and absence in most cases of acute super-infection by Staphylococcus aureus and/or streptococci. Treatment is based mainly on antibiotics. Various bacteria are involved; they are often part of the resident flora and may combine in polymicrobial infections, and they consist mainly of two families: coagulase-negative staphylococci (CNS) and anaerobes. Numerous antibiotics are active against CNS: betalactamins, lincosamides, macrolides, rifampicin, tetracyclines and fluoroquinolones. Antibiotics active against anaerobes include metronidazole, betalactamins, lincosamides and one fluoroquino...

Root discolouration following short‚?źterm application of steroid medicaments containing clindamycin, doxycycline or demeclocycline

Abstract Discolouration of teeth following application of intra‚?źcanal antibiotic pastes is a clinical concern. This laboratory study compared the extent of tooth discolouration from three antibiotic pastes over 4 weeks. A total of 120 root samples were prepared and the canals filled with either Ledermix (demeclocyline), Odontopaste (clindamycin) or DoxyPaste (doxycycline). Roots were photographed before and 2 or 4 weeks after incubation at 37¬įC and 100% humidity in complete darkness in opaque containers. Digital images were standardised and assessed for changes in luminosity. Ledermix paste caused the most discolouration of the three, at both 2 and 4 weeks. There was no significant difference between DoxyPaste and Odontopaste at 2 weeks, whereas at 4 weeks, DoxyPaste caused a greater de...

Clindamycin: Acute interstitial nephritis in an elderly patient: case report

(Source: Reactions)<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>

Odontogenic infections: An 8-year epidemiologic analysis in a dental emergency outpatient care unit.

Conclusions. Early recognition, diagnosis and management of odontogenic infections are requisite for avoiding or minimizing the development of potential complications. Strategies and evidence-based protocols should be developed within the dental ambulatory care sector, advancing interdisciplinary cooperation between general dentists and oral or maxillofacial surgeons. PMID: 22816380 [PubMed - as supplied by publisher] (Source: Acta Odontologica Scandinavica)

Multidrug‚?źresistant Coagulase‚?źnegative Staphylococci (CoNS) in Food Animals

ConclusionsMultidrug resistance and resistance to non ő≤‚?źlactam antimicrobials are common in CoNS in animals.Significance and Impact of the StudyThe data improve our understanding on the extent to which CoNS contribute to the dissemination of antimicrobial resistance in the food production environment.¬© 2012The Authors Journal of Applied Microbiology ¬© 2012 The Society for Applied Microbiology (Source: Journal of Applied Microbiology)

Molecular mechanism of macrolide-lincosamide resistance in Moraxella catarrhalis.

This study represents the first evidence to this effect in M. catarrhalis. PMID: 22820696 [PubMed - as supplied by publisher] (Source: Journal of Medical Microbiology)

Clindamycin-resistant methicillin-resistant Staphylococcus aureus: epidemiologic and molecular characteristics and associated clinical factors

Abstract: In this prospective, observational study of 618 consecutive adult patients with skin and soft tissue infections (SSTI) caused by methicillin-resistant Staphylococcus aureus (MRSA), the clinical characteristics, molecular epidemiology, and outcome of patients with clindamycin-resistant MRSA (n = 64) and clindamycin-susceptible MRSA (n = 554) were compared (including factors predictive of clindamycin-resistant MRSA SSTI). Patients with clindamycin-resistant MRSA were more likely to have had antibiotic exposure within 3 months (37.5% versus 17%, P < 0.01), surgery (25% versus 8%, P < 0.01), MRSA infection/colonization within 12 months (23% versus 7%, P < 0.01), or intravascular catheters (5% versus 0.5%, P = 0.02). On multivariate analysis, previous surgery (adjusted odds ratio [AOR...

Antibiotic resistance of microbial strains isolated from Korean acne patients

We examined the species of bacteria aerobically and anaerobically isolated from 100 Korean acne patients. Among the bacteria isolated, Staphylococcus epidermidis (36 patients) was the most common, followed by Propionibacterium acnes (30 patients). Eleven strains of P.¬†acnes (36.7%) and 25 strains of S.¬†epidermidis (69.4%) were resistant to one or other of the antibiotics tested. A higher proportion of P.¬†acnes isolates were resistant to clindamycin (30%) and erythromycin (26.7%), than to any other antibiotics tested (P‚??=‚??0.0003). Some S.¬†epidermidis isolates were resistant to tetracycline and doxycycline in addition to clindamycin and erythromycin. In the previous studies, few strains of P.¬†acnes were found to be resistant to any of the antibiotics, but this study shows that antib...<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>

Prospective multicentre feasibility study of a quality of care indicator for intravenous to oral switch therapy with highly bioavailable antibiotics

Conclusions This quality indicator was found to be generally feasible in hospitals across three European countries, and informative about the local need for clinical quality improvement. (Source: Journal of Antimicrobial Chemotherapy)

Efficacy and safety of a nano-emulsion gel formulation of adapalene 0.1% and clindamycin 1% combination in acne vulgaris: A randomized, open label, active-controlled, multicentric, phase IV clinical trial

Conclusions: The nano-emulsion gel formulation of adapalene and clindamycin combination appears to be more efficacious and better tolerated than the conventional formulation for the treatment of acne vulgaris in Indian patients. Further studies can elucidate the comparative treatment benefits of this nano-emulsion gel formulation. (Source: Indian Journal of Dermatology, Venereology and Leprology)

FDA approves generic version of acne treatment

FDA has approved Perrigo Company&acirc;&euro;&trade;s abbreviated new drug application for a generic version of clindamycin phosphate and benzoyl peroxide 1.2%/5% gel (Duac Gel, Stiefel Laboratories), the company recently announced in a statement. The gel is indicated for the topical treatment of inflammatory acne vulgaris. (Source: Drug Topics - Pharmacy News)

Incidence and characterization of Staphylococcus aureus in fishery products marketed in Galicia (Northwest Spain).

Authors: Vázquez-Sánchez D, López-Cabo M, Saá-Ibusquiza P, Rodríguez-Herrera JJ Abstract A total of 298 fishery products purchased from retail outlets in Galicia (NW Spain) between January 2008 and May 2009 were analyzed for the presence of Staphylococcus aureus. S. aureus was detected in a significant proportion of products (~25%). Incidence was highest in fresh (43%) and frozen products (30%), but it was high in all other categories: salted fish (27%), smoked fish (26%), ready-to-cook products (25%), non-frozen surimis (20%), fish roes (17%) and other ready-to-eat products (10%). A significant proportion of smoked fish, surimis, fish roes and other ready-to-eat products did not comply with legal limits in force. RAPD-PCR of 125 S. aureus isolated from fishery products was ca...<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>

Epidemiological and molecular characteristics of clinical isolates of Streptococcus pyogenes collected between 2005 and 2008 from Chinese children.

Authors: Liang Y, Liu X, Chang H, Ji L, Huang G, Fu Z, Zheng Y, Wang L, Li C, Shen Y, Yu S, Yao K, Ma L, Shen X, Yang Y Abstract The aim of this study was to explore the epidemiological and molecular characteristics of Streptococcus pyogenes in children from different cities in mainland China who were diagnosed with scarlet fever, impetigo and pharyngitis, as well as to detect asymptomatic carriers, between 2005 and 2008, and to compare the results with isolates from rural Chinese children with acute glomerulonephritis in 2005 and in the 1990s. Susceptibility tests to determine MICs and analysis of the presence of erythromycin-resistant genes (mefA, ermB and ermA) and emm gene typing were performed on 466 S. pyogenes isolates from Beijing, Shanghai, Chongqing and Shenzhen. Superant...

Probable clindamycin-induced ageusia, xerostomia, and burning mouth syndrome.

Authors: Rosen S, Trefflich D, Rosen MA PMID: 22764332 [PubMed - in process] (Source: The Annals of Pharmacotherapy)

Acute generalized erythematous pustulosis occurring with Hailey-Hailey disease.

Authors: Deng A, Lowitt M Abstract A 70-year-old woman urgently presented with severe eruptive skin dermatitis associated with fever and malaise 7 days after taking clindamycin for an unknown skin eruption. She had a 40-year-long history of well-controlled Hailey-Hailey disease. Physical examination revealed erythrodermic skin changes covering more than 80% of the patient's body surface, with hundreds of nonfollicular pustules. Many of the pustules fused into large bullae, involving the intertriginous as well as the extensor areas, sparing the mucosa. Her body temperature was 103 degrees F. Laboratory workup was significant for neutrophilia with a white cell count &gt; 10,000/mm3. PMID: 23008946 [PubMed - in process] (Source: Skinmed)

Antimicrobial resistance and molecular typing of Staphylococcus aureus bloodstream isolates from hospitals in Peru

Conclusions: MRSA rate among bloodstream isolates in Peru was 50%, with MLST CC5/t149/SCCmec I representing the most frequent clone. (Source: Journal of Infection)

Antiseptics and disinfectants for the treatment of bacterial vaginosis: a systematic review

Conclusion: The use of antiseptics and disinfectants for the treatment of BV has been poorly studied and most studies are somehow methodologically flawed. Limited data indicate that some antiseptics may have equal efficacy in treating BV on short term compared to treatment with clindamycin or metronidazole. Further study is however warranted with special regard to long-term efficacy and safety of antiseptics and disinfectants for vaginal use. (Source: BMC Infectious Diseases)<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>

Clindamycin: First report of Kounis syndrome leading to acute myocardial infarction: case report

(Source: Reactions)

CLINDAMYCIN PHOSPHATEcream [E. FOUGERA CO. A Division Of Fougera Pharmaceuticals Inc.]

Updated Date: Jun 21, 2012 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

Epidemiology of Clostridium difficile infections in a tertiary‚?źcare hospital in Korea

Clin Microbiol InfectAbstractTo survey healthcare‚?źassociated Clostridium difficile infection (HA‚?źCDI) in a 900‚?źbed tertiary‚?źcare hospital, we prospectively investigated the epidemiology of CDI and distribution of PCR‚?źribotypes. From February 2009 through January 2010, all patients with HA‚?źCDI were enrolled. Epidemiological information and prescription records for antibiotics were collected. The C.‚??difficile isolates were characterized using reference strains and were tested for antibiotic susceptibility. During the survey, incidence of HA‚?źCDI was 71.6 per 100‚??000 patient‚?źdays. In total, 140 C.¬†difficile isolates were obtained from 166 patients with HA‚?źCDI. The PCR‚?źribotyping yielded 38 distinct ribotypes. The three most frequently found ribotypes made up 56.4% of a...

Active infective endocarditis due to Erysipelothrix rhusiopathiae: zoonosis caused by vancomycin-resistant gram-positive rod

Abstract&nbsp;&nbsp;A 42-year-old female who was a voluntary worker in a school for handicapped children was referred to us for surgery for active infective endocarditis. Trans-esophageal echocardiography showed 2 large mobile vegetations on the aortic valve and severe aortic regurgitation. Aortic valve replacement was performed to prevent septic embolism and deterioration of congestive heart failure. The empiric therapy with vancomycin, ampicillin, and gentamycin was initiated because a pathogen was not identified. But Erysipelothrix rhusiopathiae (gram-positive rod) was isolated on the 4th day after surgery. The target therapy with penicillin G and clindamycin was started and continued for 4&nbsp;weeks after surgery. The inflammatory parameters improved steadily and the patient was ...

CLINDAMYCIN HYDROCHLORIDEcapsule, Gelatin Coated [CorePharma, LLC]

Updated Date: Jun 5, 2012 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>

Limited course of antibiotic treatment for chorioamnionitis.

CONCLUSION: : A limited course of antibiotics was sufficient for virtually all patients (99%) with chorioamnionitis who had a vaginal delivery. However, a subset of patients who delivered by cesarean may have benefited from a more extended course of antibiotic therapy. LEVEL OF EVIDENCE: : III. PMID: 22617573 [PubMed - in process] (Source: Obstetrics and Gynecology)

Investigation of the antibiotic resistance and biofilm formation of Staphylococcus aureus strains isolated from gangrenous mastitis of ewes.

In this study, Staphylococcus aureus strains (n = 110) isolated from seven ewe flocks in Sanliurfa, Turkey were screened for antibiotic resistance and biofilmforming ability as well as for genes associated with antibiotic resistance and biofilm-forming ability. All isolates were found to be susceptible to oxacillin, gentamicin, clindamycin, cefoxitin, tetracycline, vancomycin, amoxicillin-clavulanic acid, ciprofloxacin and sulphamethoxazole-trimethoprim. The percent proportions of strains resistant to penicillin G, ampicillin and erythromycin were 27.2% (n = 30), 25.4% (n = 28) and 6.3% (n = 7), respectively. Regarding the antibiotic resistance genes, 32 (29%) isolates carried the blaZ and 8 (7.2%) the ermC gene. Other resistance genes were not detected in the isolates. All isolates showed...

Sensitivity of Human Strains of Oxalobacter formigenes to Commonly Prescribed Antibiotics

Conclusion: Four human strains of Oxf are sensitive to a number of antibiotics commonly used in clinical practice; however, minimum inhibitory concentrations differ between strains. (Source: Urology)

Clindamycin Plus Quinine for Treating Falciparum MalariaClindamycin Plus Quinine for Treating Falciparum Malaria

Is clindamycin plus quinine an adequate alternative treatment for uncomplicated malaria? Malaria Journal (Source: Medscape Today Headlines)

Detection of various types of resistance patterns and their correlation with minimal inhibitory concentrations against clindamycin among methicillin-resistant Staphylococcus aureus isolates

Conclusion: Detection of iMLS B resistance among MRSA helps to avoid treatment failure with clindamycin. Studying the subpopulation inside the clindamycin-sensitive zone raises the question of existence of hetero-resistance or some other mechanism, which needs further study. (Source: Indian Journal of Medical Microbiology)<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>

Molecular characterization and clonal genetic diversity of methicillin-resistant Staphylococcus aureus of pig origin in Taiwan.

In conclusion, this study reported the first identified LA-MRSA clone of MDR-ST9-t899-V lacking ccrC dominant in pig farms in western Taiwan that differed from ST398 in Europe and North America. Close monitoring of this MDR unique clone is warranted to survey its spread from livestock to humans. PMID: 22640551 [PubMed - as supplied by publisher] (Source: Comparative immunology, microbiology and infectious diseases.)

The Cephalosporin Use in the Penicillin Allergic Patient

Many patients present for orthopedic surgeries with penicillin or cephalosporin allergies. These allergies are unbiquous and range from hives, shortness of breath to an upset stomach. The pre-operative antibiotic of choice for these procedures is Ancef. In the past, these ‚??allergic‚?Ě patients would be treated with vancomycin or clindamycin pre-operatively. This last minute antibiotic change lead to increase in pre-op nursing and pharmacy staffing time, delayed surgeries, operating room scheduling issues and increased risk of complications for the patient (ie, MDRO, renal issues or c-diff infections etc). (Source: American Journal of Infection Control)

Azithromycin/clindamycin: Clostridium difficile infection: case report

(Source: Reactions)

CLINDAMYCIN PHOSPHATElotion CLINDAMYCIN PHOSPHATEsolution CLINDAMYCIN PHOSPHATEgel [E. FOUGERA CO. A Division Of Fougera Pharmaceuticals Inc.]

Updated Date: May 21, 2012 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

Epidemiology of Clostridium difficile infections in a tertiary care hospital in Korea

AbstractClostridium difficile infection (CDI) is one of the most important hospital infections, and during the past decade its incidence has increased markedly worldwide. Prior exposure to antimicrobials, which can disrupt the normal flora, is the main risk factor for CDI. Clindamycin and extended‚?źspectrum cephalosporins (ESC) are the antibiotics most frequently implicated in CDI, whereas fluoroquinolones are considered risk factors for CDI caused by the hypervirulent BI/NAP1/027 (ribotype 027) strains that have become resistant to newer fluoroquinolones (moxifloxacin, levofloxacin, and gatifloxacin). Additional risk factors for CDI include age, underlying co‚?źmorbidities, and hospital admission¬© 2012 The Authors Clinical Microbiology and Infection ¬© 2012 European Society of Clinical ...<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>

Genotypic characterization and safety assessment of lactic acid bacteria from indigenous African fermented food products

Conclusions: The resistance to kanamycin and vancomycin is probably an intrinsic feature since similarobservations were reported in the literature for LAB. Low prevalence of pathogenicityindicator traits were observed among the isolates especially with the presence of poorhaemolytic activities and they could therefore be considered as interesting candidates forselection of starter cultures or probiotics for different applications. (Source: BMC Microbiology - Latest articles)

Multidrug-resistant clones of community-associated MRSA isolated from Chinese children and the resistance genes to clindamycin and mupirocin.

This study aims to correlate the multidrug resistance (MDR) and sequence type (ST) clones of community-associated methicillin-resistant Staphylococcus aureus (CA-MRSA), to identify the genes responsible for clindamycin and mupirocin resistance in Staphylococcus aureus (SA) isolated from pediatric hospitals in mainland China. Up to 435 SA isolates were collected. Compared with community-associated methicillin-susceptible Staphylococcus aureus (CA-MSSA), the resistance rates of CA-MRSA to ciprofloxacin, chloramphenicol, gentamicin and tetracycline were higher (19.0% vs 2.6%, P&lt;0.001; 14.7% vs 3.1%, P&lt;0.001; 14.7% vs 3.1%, P&lt;0.01; and 46.0% vs 13.3%, P&lt;0.001). Compared with hospital-associated MRSA (HA-MRSA), the resistance rates of CA-MRSA to ciprofloxacin, gentamicin, rifampin, ...

In reply

Synovitis, acne, pustulosis, hyperostosis, osteitis (SAPHO) syndrome affecting the mandible is rare. Primarily for this reason, there is still no generally accepted treatment strategy. Deng et al. reported an interesting case of a patient suffering from SAPHO syndrome involving the mandible. They presented the results of a single case treated with roxithromycin and concluded that this conservative approach seemed to be effective. This is consistent with other reports in which the usefulness of antibiotic treatment (roxithromycin, tetracycline, clindamycin, macrolides) has been described. Deng et al. considered that medical treatment should be attempted before considering surgical intervention because of the potentially severe complications, including paresthesia of the lower lip, facial as...

Association between PCR ribotypes and antimicrobial susceptibility among Clostridium difficile isolates from healthcare-associated infections in South Korea

In conclusion, the common ribotypes 018, 017 and 001 of C. difficile have high rates of resistance to clindamycin and moxifloxacin, but differ greatly in the frequency of rifaximin resistance. (Source: International Journal of Antimicrobial Agents)

Methicillin-resistant Staphylococcus aureus bacteremia at a university hospital in Japan

In this study, we assessed the clinical characteristics and optimum management of 115 patients with MRSA bacteremia who were admitted to Osaka University Hospital between January 2006 and December 2010. Sixty-nine of the patients survived and 46 died of heart failure or renal failure. The nonsurvivors had reduced levels of platelets and albumin, and increased aspartate aminotransferase, total bilirubin, blood urea nitrogen, and creatinine levels. Other causes of death included sepsis, septic shock plus respiratory failure, disseminated intravascular coagulation, and unknown causes. However, a significant number of those whose infections were catheter-derived survived. Nonsurvivors were more often administered catecholamines and consultation with an infection-control team (ICT) was s...<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>

Sulphadiazine-induced obstructive renal failure complicating treatment of HIV-associated toxoplasmosis

A patient with newly-diagnosed HIV infection and biopsy-proven cerebral toxoplasmosis was treated with sulphadiazine and pyrimethamine. Despite adequate hydration and daily examination of urine for sulphadiazine crystals obstructive uropathy due to bilateral ureteric stones with hydronephrosis occurred, resulting in rapid onset renal failure. Sulphadiazine was discontinued and clindamycin was substituted. With intravenous fluid hydration and bilateral nephrostomies the urolithiasis resolved. This case serves to remind clinicians of the need for vigilance when treating cerebral toxoplasmosis with sulphadiazine, in order to avoid this potentially serious complication of treatment. (Source: International Journal of STD and AIDS)

Clinical and microbiologic characteristics of tcdA-negative variant clostridium difficile infections

Conclusions: The clinical course of A-B+ CDI is not different from that of A+B+ CDI. Clindamycin use is asignificant risk factor for the acquisition of tcdA-negative variant strains. (Source: BMC Infectious Diseases)

VELTIN (Clindamycin Phosphate And Tretinoin) Gel [Stiefel Laboratories Inc]

Updated Date: May 8, 2012 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

A systematic review of the safety and efficacy of artemether-lumefantrine against uncomplicated Plasmodium falciparum malaria during pregnancy

There is evidence to suggest that the pharmacokinetics of anti-malarial drugs may change in pregnancy, although the majority of studies report high cure rates and adequate tolerability. The paper reinforces the WHO recommendation to treat uncomplicated falciparum malaria with quinine plus clindamycin in early pregnancy and ACT in later pregnancy. (Source: Malaria Journal)

Characterization of MLSb resistance among Staphylococcus aureus and Staphylococcus epidermidis isolates carrying different SCCmec types

ABSTRACTThis work characterizes MLSb resistance in 39 methicillin‚?źresistant Staphylococcus aureus (MRSA) and 32 Staphylococcus epidermidis (MRSE) isolates. For 21 erm(A) gene encoding MRSA isolates 71.4% carried the SCCmecIII, while for 12 isolates carrying the erm(C) gene 83.3% had the SCCmecIV. Among the 25 MRSE isolates positive for the erm(C) gene 80% had the SCCmecIV or nontypeable cassettes. Isolates carrying these genes presented MIC90‚?•256őľg/ml to erythromycin and clindamycin. The msr(A) gene was associated with low MIC90 to these drugs. The erm(A) gene was associated to SCCmecIII in MRSA isolates, while the erm(C) gene was related to SCCmecIV in both MRSA and MRSE isolates. (Source: Microbiology and Immunology)<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>

Heat stable antimicrobial activity of Burkholderia gladioli OR1 against clinical drug resistant isolates.

We report here the antimicrobial activity of B. gladioli against drug resistant bacterial pathogens. Methods: The bacterial culture was identified using morphological, biochemical and 16S rRNA gene sequencing techniques. The antimicrobial activity of the identified organism against a range of microbial pathogens was checked by Kirby-Bauer's disc diffusion method. The antimicrobial compounds in the cell free supernatant were chloroform-extracted and separated by thin layer chromatography (TLC). Results: B. gladioli OR1 exhibited broad spectrum antimicrobial activity against drug resistant clinical isolates belonging to various genera of bacteria (Staphylococcus, Enterobacter, Enterococcus, Acinetobacter and Citrobacter) and a fungus (Candida). Based on TLC profile and bioautography studies,...

Antibiotic susceptibility in prostate‚?źderived Propionibacterium acnes isolates

The aim of this study was to determine antibiotic susceptibility of Propionibacterium acnes isolates from prostate. Prostate‚?źderived P. acnes isolates (n¬†=¬†24, Ume√• & √?rebro, Sweden, 2007‚??2010) and a panel of control strains (n¬†=¬†25, Sweden) collected from skin and deep infections were assessed for resistance to penicillin G, piperacillin‚??tazobactam, imipenem, gentamicin, azithromycin, erythromycin, vancomycin, ciprofloxacin, moxifloxacin, tetracycline, tigecycline, fusidic acid, clindamycin, rifampicin, linezolid, daptomycin, trimethoprim‚??sulfamethoxazole, and metronidazole. In addition, the isolates were tested for inducible clindamycin resistance. All prostate derived P. acnes isolates displayed wild‚?źtype distribution of MIC‚?źvalues, without evidence of acquired res...

CLINDAMYCIN HYDROCHLORIDEcapsule [Teva Pharmaceuticals USA Inc]

Updated Date: Apr 26, 2012 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

Macrolide and Tetracycline Resistance in Clinical Strains of Streptococcus agalactiae Isolated in Tunisia.

Authors: Hraoui M, Boutiba-Ben Boubaker I, Rachdi M, Slim A, Ben Redjeb S Abstract Between 2007 and 2009, 226 clinical strains of Streptococcus agalactiae, recovered from women genital specimens and from gastric fluids or ear specimens of infected newborns were isolated at the laboratory of Microbiology of Charles Nicolle Hospital of Tunis. They were investigated to determine the prevalence of antibiotic resistance and to characterize the mechanisms of resistance to macrolide and tetracycline. All strains were susceptible to penicillin, ampicillin and quinupristun-dalfopristin. They were resistant to chloramphenicol (3.1%), rifampin (19.1%), erythromycin (40%) and tetracycline (97.3%). 3.1% were highly resistant to streptomycin and 1.3% to gentamicin. Among the erythromycin resista...

clindamycin and benzoyl peroxide gel, Benzaclin, Acanya, Duac

Title: clindamycin and benzoyl peroxide gel, Benzaclin, Acanya, DuacCategory: MedicationsCreated: 9/30/2001 2:36:00 PMLast Editorial Review: 4/23/2012 12:00:00 AM (Source: MedicineNet Skin General)<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>

Do automated text messages increase adherence to acne therapy? Results of a randomized, controlled trial

Conclusions: Electronic reminders in the form of daily, customized text messages were not associated with significant differences in adherence to topical medications in patients with mild to moderate acne and had no significant effect on therapeutic response. (Source: Journal of the American Academy of Dermatology)

Listeria fleischmannii sp. nov., isolated from cheese.

Authors: Bertsch D, Rau J, Eugster MR, Haug MC, Lawson PA, Lacroix C, Meile L Abstract A polyphasic study was performed on three isolates (LU2006-1(T), LU2006-2 and LU2006-3), which were sampled independently from cheese in western Switzerland in 2006, as well as a fourth isolate (A11-3426) detected in 2011. They could all be assigned to the genus Listeria but not to any known species. Phenotypic and chemotaxonomic data were compatible with other Listeria species. Phylogenetic analyses revealed the closest relationship to members of the genus Listeria, however DNA-DNA hybridizations demonstrated that the isolates did not belong to any currently described species. Cell wall binding domains of L. monocytogenes bacteriophage endolysins were able to attach to the isolates, confirming t...

CLINDAMYCIN HYDROCHLORIDEcapsule [Cardinal Health]

Updated Date: Apr 18, 2012 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

A Systematic Review of Treatments for Hidradenitis Suppurativa [Study]

Conclusions&nbsp; Shown to be effective treatments for HS were a clindamycin-rifampin combination regimen, a course of infliximab, monthly Nd:YAG laser sessions, and surgical excision and primary closure with a gentamicin sulfate&ndash;collagen sponge. Most therapies used to treat HS were supported by limited or weak scientific evidence. A treatment approach is presented based on the evidence and on clinical experience at the Follicular Disorders Clinic, Department of Dermatology, Henry Ford Hospital, Detroit, Michigan. This review emphasizes the need for large randomized controlled trials to evaluate treatment options for HS. (Source: Archives of Dermatology)<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>

Characterizations of Clinical Isolates of Clostridium difficile by Toxin Genotypes and by Susceptibility to 12 Antimicrobial Agents, Including Fidaxomicin (OPT-80) and Rifaximin: A Multicenter Study in Taiwan.

This study found the diversity of toxigenic and nontoxigenic strains of C. difficile found in the healthcare setting in Taiwan. All isolates tested were susceptible to metronidazole and vancomycin. Fidaxomicin exhibited potent in vitro activity against all isolates tested, while more than 10% of Taiwanese isolates with rifaximin MICs of ‚?•128 őľg/ml needs more concerns. PMID: 22508299 [PubMed - as supplied by publisher] (Source: Antimicrobial Agents and Chemotherapy)

MRSA Rates and Antibiotic Susceptibilities from Skin and Soft Tissue Cultures in a Suburban ED

Conclusions: There has been a significant increase in the rates of MRSA SSTIs in a suburban ED, yet only 1 in 4 SSTIs are caused by MRSA. Both MRSA and MSSA are completely susceptible to vancomycin, linezolid, rifampin, nitrofurantoin, and chloramphenicol. Gentamicin, tetracycline, and TMP-SMZ cover > 97% of both isolates. (Source: The Journal of Emergency Medicine)

CLINDAMYCIN PHOSPHATEcream [Preferred Pharmaceuticals, Inc]

Updated Date: Apr 10, 2012 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

Clindamycin: Oesophageal ulcer: case report

(Source: Reactions)<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>

Prevalence, bacterial causes, and antimicrobial susceptibility profile of mastitis isolates from cows in large-scale dairy farms of Northern Ethiopia

Abstract&nbsp;&nbsp;The study was undertaken to determine the prevalence of bovine mastitis, isolate mastitis causing bacteria, assess the association of some risk factors, and determine the antibiotic resistance pattern of bacterial isolates in cows in large-scale dairy farms of Northern Ethiopia. A total of 305 lactating and nonlactating cows were included in the present study. The overall prevalence of clinical and subclinical mastitis was 3.6 and 33.8&nbsp;%, respectively. The quarter level prevalence was 15.4&nbsp;%; from which, 11.9 and 1.1&nbsp;% were subclinical form and blind teat, respectively, while the remaining 2.4&nbsp;% were of clinical form. Staphylococcus aureus accounted for 36&nbsp;% of the isolates followed by Escherichia coli (27.3&nbsp;%). Risk factors including a...

Antimicrobial activity of the novel pleuromutilin antibiotic BC-3781 against organisms responsible for community-acquired respiratory tract infections (CARTIs)

Conclusions BC-3781 was very active against organisms commonly associated with CARTIs and its activity was not negatively influenced by resistance to other antimicrobials. (Source: Journal of Antimicrobial Chemotherapy)

Population Pharmacokinetics of Clindamycin orally and intravenously administrated in osteomyelitis patients.

Conclusions: The current recommendation of 600 mg (TID) seems to be effective up to 75kg; the dose should be raised to 900 mg (TID) thereafter. These assumptions should be prospectively confirmed.© 2012 The Authors. British Journal of Clinical Pharmacology © 2012 The British Pharmacological Society (Source: British Journal of Clinical Pharmacology)

Pneumocystis jirovecii: a peculiar fungus posing particular problems for therapy and prophylaxis

SummaryPneumocystis spp. are peculiar fungi, because they lack ergosterol in their cytoplasmic membrane. Furthermore, they go through various sexual and non‚?źsexual stages in a living host; the cysts, which are able to survive in the environment, are the infectious agents. The various species are more or less specific for a mammalian host. Pneumocystis jirovecii is pathogenic for humans. Transient colonisation of children and adults with this fungus occurs frequently. As a typical opportunist it can induce an overt disease in immunocompromised patients only. In particular those patients with an impaired cell‚?źmediated immune system, namely AIDS patients or transplant recipients taking immunosuppressive agents, are affected. The leading clinical feature is a bilateral interstitial pneumon...<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>

Meticillin-resistant Staphylococcus pseudintermedius: clinical challenge and treatment options.

Authors: Frank LA, Loeffler A Abstract Meticillin-resistant Staphylococcus pseudintermedius (MRSP) has emerged as a major therapeutic challenge for small animal veterinarians over the past 10‚??years and continues to spread worryingly in many countries. This review focuses on the clinical aspects of MRSP infections seen in patients with skin disease and on currently available treatment options. In addition, it discusses the implications for in-contact people, other animals and the environment, because infection control strategies are likely to have a significant impact on treatment success and prevention of spread. There is currently no indication that MRSP is more virulent than meticillin-susceptible S.¬†pseudintermedius, and reported infections have mostly been treated successful...

CLINDAMYCIN (Clindamycin Phosphate) Injection, Solution [Sagent Pharmaceuticals]

Updated Date: Apr 2, 2012 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

Pneumocystis jirovecii: a peculiar fungus posing particular problems for therapy and prophylaxis

SummaryPneumocystis spp. are peculiar fungi, because they lack ergosterol in their cytoplasmic membrane. Furthermore, they go through various sexual and non‚?źsexual stages in a living host; the cysts, which are able to survive in the environment, are the infectious agents. The various species are more or less specific for a mammalian host. Pneumocystis jirovecii is pathogenic for humans. Transient colonisation of children and adults with this fungus occurs frequently. As a typical opportunist it can induce an overt disease in immunocompromised patients only. In particular those patients with an impaired cell‚?źmediated immune system, namely AIDS patients or transplant recipients taking immunosuppressive agents, are affected. The leading clinical feature is a bilateral interstitial pneumon...

Clinical audit of the microbiology of otorrhoea referred to a tertiary hospital in Singapore.

Conclusion: The common microorganisms involved in otorrhoea in Singapore are P. aeruginosa, Aspergillus and S. aureus. Resistant strains of Pseudomonas spp. are now present. Methicillin-resistant S. aureus is increasingly prevalent and highly sensitive to vancomycin. Aminoglycoside and fluoroquinolone-containing eardrops are suitable first-line topical antimicrobials. Cloxacillin may be started should a concomitant oral antimicrobial be warranted empirically or for S. aureus infections. Otomycosis should be considered in patients who show no improvement with antibiotics. PMID: 22511046 [PubMed - in process] (Source: Singapore Medical Journal)<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>

Evaluation of antimicrobial activity of certain combinations of antibiotics against in vitro Staphylococcus epidermidis biofilms.

The objective of this study was to compare susceptibilities of biofilm-grown cells to single antibiotic and in combination with others to identify those that were effective against S. epidermidis biofilms. Methods: Biofilms were grown in the MBEC‚?Ę assay system. The use of this methodology allowed a rapid testing of an array of antibiotics alone (eight) and in combination (25 double combinations). The antibacterial effect of all treatments tested was determined by colony forming units (cfu) enumeration method. Results: The MBEC‚?Ę assay system produced multiple and reproducible biofilms of S. epidermidis. Although none of the antibiotics tested have demonstrated an antimicrobial effect (log reduction &gt;3) against all S. epidermidis isolates biofilms, but combinations containing rifampi...

CLINDAMYCIN HYDROCHLORIDEcapsule [Preferred Pharmaceuticals, Inc]

Updated Date: Mar 30, 2012 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

In vitro antimicrobial activity of pannarin alone and in combination with antibiotics against methicillin-resistant Staphylococcus aureus clinical isolates

Abstract: The in vitro antimicrobial activities of pannarin, a depsidone isolated from lichens, collected in several Southern regions of Chile (including Antarctica), was evaluated alone and in combination with five therapeutically available antibiotics, using checkerboard microdilution assay against methicillin-resistant clinical isolates strains of Staphylococcus aureus. MIC90, MIC50, as well as MBC90 and MBC50, were evaluated. A moderate synergistic action was observed in combination with gentamicin, whilst antagonism was observed in combination with levofloxacin. All combinations with erythromycin were indifferent, whilst variability was observed for clindamycin and oxacillin combinations. Data from checkerboard assay were analysed and interpreted using the fractional inhibitory concen...

Clindamycin: Exanthematous rash: 2 case reports

(Source: Reactions)

Clostridium difficile genotypes other than ribotype 078 that are prevalent among human, animal and environmental isolates

Conclusion: Our results show that many other types in addition to PCR Ribotype 078 are shared between humans and animals and that the most prevalent genotypes in humans have the ability to survive also in the environment and several animal hosts. The genetic relatedness observed with PFGE suggests that transmission of given genotype from one reservoir to the other is likely to occur. (Source: BMC Microbiology - Latest articles)<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>

Effects of probiotics and antibiotics on the intestinal homeostasis in a computer controlled model of the large intestine

Conclusions: Administration of VSL#3 parallel with the clindamycin therapy had a beneficial and stabilizing effect on the intestinal metabolic homeostasis by decreasing toxic metabolites and protecting the endogenic microbiota from destruction. Probiotics could be a reasonable strategy in prevention of antibiotic associated disturbances of the intestinal homeostasis and disorders. (Source: BMC Microbiology - Latest articles)

Conference presentations: Two combination acne gels incorporating clindamycin do well in phase III trials

Source: Reuters Health News Area: News Data from two phase III trials presented at the American Academy of Dermatology's annual conference have shown that two different gels for treating acne vulgaris, each combining clindamycin with another agent, performed well in 12-week late-stage trials. &#160; In one trial, a combination of clindamycin phosphate 1.2% and tretinoin 0.025%, was associated with a 52.1% reduction in acne lesions in an open-label study of 154 patients in Brazil. In a separate double-blind, parallel-group, vehicle-controlled study, Stiefel Laboratories' combination of clindamycin phosphate 1.2% and benzoyl peroxide 3% was associated with acne improvement by two grades out of four in 39% of 1315 patients. In both trials, the rate of adverse events was low, and both gel...

Risk factors for Clostridium difficile toxin-positive diarrhea: a population-based prospective case‚??control study

Two acne gels that include clindamycin do well in phase III trials

NEW YORK (Reuters Health) - Two different gels for treating acne vulgaris, each combining clindamycin with another agent, performed well in 12-week late-stage trials reported at the American Academy of Dermatology's annual conference in San Diego this week. (Source: Modern Medicine)

Tooth discolouration: Staining effects of various sealers and medicaments

AbstractThe aim of this investigation was to quantify the discolouration of tooth roots caused by various medicaments and sealers. The roots of extracted teeth were chemo‚?źmechanically prepared and the smear layer removed. The roots were filled with either Multi‚?źCal (Pulpdent Corporation, Watertown, MA, USA), Ledermix (Lederle Laboratories, Wolfratshausen, Germany), 2% chlorhexadine acetate in polyethylene glycol (PEG), 5% clindamycin in PEG, PEG alone (as a vehicle control), sealers AH26 (De Trey Dentsply, Zurich, Switzerland), AH Plus (De Trey Dentsply), an experimental epoxy resin with zirconium dioxide (Millenium Chemicals, Rockingham, Western Australia) or Araldite (Selleys Pty Ltd, Sydney, Australia). The roots were maintained at 37¬įC in dark humid conditions and standardised ima...<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>

Epidemiological and molecular characteristics of clinical isolates of Streptococcus pyogenes from Chinese children between 2005 and 2008.

Authors: Liang Y, Liu X, Chang H, Ji L, Huang G, Zhou F, Zheng Y, Wang L, Li C, Shen Y, Yu S, Yao K, Ma L, Shen X, Yang Y Abstract To explore the epidemiological and molecular characteristics of Streptococcus pyogenes in children from different cities in the mainland China who were diagnosed with scarlet fever, impetigo, and pharyngitis, as well as asymptomatic carriers, between 2005-2008; and to compare results with isolates from rural Chinese children with acute glomerulonephritis in 2005 and the 1990s. Susceptibility tests with minimal inhibitory concentrations (MICs), erythromycin-resistant genes (mefA, ermB, and ermA), and emm typing were performed on 466 S. pyogenes isolates from Beijing, Shanghai, Chongqing, and Shenzhen. Superantigen genes (speA and speC) were examined by p...

Tooth discolouration: Staining effects of various sealers and medicaments

AbstractThe aim of this investigation was to quantify the discolouration of tooth roots caused by various medicaments and sealers. The roots of extracted teeth were chemo‚?źmechanically prepared and the smear layer removed. The roots were filled with either Multi‚?źCal (Pulpdent Corporation, Watertown, MA, USA), Ledermix (Lederle Laboratories, Wolfratshausen, Germany), 2% chlorhexadine acetate in polyethylene glycol (PEG), 5% clindamycin in PEG, PEG alone (as a vehicle control), sealers AH26 (De Trey Dentsply, Zurich, Switzerland), AH Plus (De Trey Dentsply), an experimental epoxy resin with zirconium dioxide (Millenium Chemicals, Rockingham, Western Australia) or Araldite (Selleys Pty Ltd, Sydney, Australia). The roots were maintained at 37¬įC in dark humid conditions and standardised ima...

Susceptibility testing of Atopobium vaginae for dequalinium chloride

Conclusions: This study demonstrated that dequalinium chloride inhibits and kills clinical isolates of A. vaginae at concentrations similar to those of clindamycin and lower than those of metronidazole. (Source: BMC Research Notes)

To-Go medications for decreasing ED return visits

Conclusions: For a 1-year expense of $1123, we demonstrated a 50% reduction in ED return visits for patients who were given a free, complete course of antibiotics at discharge for select conditions. (Source: The American Journal of Emergency Medicine)

Characterization of Methicillin‚?źResistant Staphylococcus aureus Isolates from Pig Carcasses in Hong Kong

This study describes the isolation and characterization of methicillin‚?źresistant Staphylococcus aureus (MRSA) from slaughtered pigs sampled from local markets in Hong Kong. The nares of 400 slaughtered pigs were cultured and MRSA isolates characterized for the presence of antibiotic‚?źresistance determinants, toxins and SCCmec and spa types using PCR. Clonality was investigated using PFGE and MLST. The prevalence of MRSA colonization of slaughter pigs was 39.3%, the majority (92%) harbouring SCCmec type IVb. Of the 157 samples yielding MRSA, 13 had two distinct MRSA strains present. Spa type t899 was predominant, with only 5/170 isolates displaying closely related types (t4474, t1939, t2922 and t5390). PFGE with sma1 and MLST confirmed the strains as ST9. Most isolates were multidrug res...<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>

Occurrence and characterization of Listeria spp. in ready-to-eat retail foods from Vancouver, British Columbia.

Novel anti‚?źacne actions of nadifloxacin and clindamycin that inhibit the production of sebum, prostaglandin E2 and promatrix metalloproteinase‚?ź2 in hamster sebocytes

AbstractAcne vulgaris is characteristic of excess sebum production and the induction of inflammatory reactions, for example, the augmentation of cytokine, prostaglandin (PG) and matrix metalloproteinase (MMP) production in sebaceous glands and pilosebaceous units. As Propionibacterium acnes is considered to be involved in the aggravation of acne vulgaris, antimicrobial agents have been found to be effective for treating acne leading to the remission of inflammation. However, it is not fully understood whether antimicrobial agents influence sebum production and/or the inflammatory reactions in sebaceous gland cells (sebocytes). In the present study, topical antimicrobial agents such as nadifloxacin (NDFX) and clindamycin (CLDM) decreased the production of triacylglycerols (TG), which are a ...

CLEOCIN PHOSPHATE (Clindamycin Phosphate) Injection, Solution [Pharmacia And Upjohn Company]

Updated Date: Mar 2, 2012 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>

CLINDESSE (Clindamycin Phosphate) Cream [Ther-Rx Corporation]

Updated Date: Mar 2, 2012 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

[Phenotypes and mechanisms of resistance to macrolides and lincosamides in Streptococcus agalactiae isolates with clinical significance in an eight-year period (2002-2010)].

Conclusions. Macrolide resistance in our area is similar to that observed in the rest of Spain, but there has been no increase in the incidence rate along the study period. PMID: 22488541 [PubMed - in process] (Source: Revista Espanola de Quimioterapia)

Inhibition of Propionibacterium acnes lipase by extracts of Indian medicinal plants

This study reports for the first time the novel antilipase activity of chebulagic acid (IC50: 60‚??őľmol‚??L‚??1) with minimum inhibitory concentration value of 12.5‚??őľg‚??mL‚??1 against P.¬†acnes. The inhibitory potential of plant extracts was further confirmed by plate assay. The organism was grown in the presence of subinhibitory concentrations of extracts from P.¬†kurroa, V.¬†negundo, T.¬†chebula, E.¬†ribes and antibiotics such as clindamycin and tetracycline. Extract from T.¬†chebula showed significant inhibition of lipase activity and number of P.¬†acnes. (Source: International Journal of Cosmetic Science)

[Use of the rapid antigen technique in the diagnosis of Streptococcus pyogenes pharyngotonsillitis.]

CONCLUSIONS: The rapid antigen test can lead to a better use of antibiotics. Its use in Paediatric Primary Health Care could be useful when, as when the result is negative, there would be no need to confirm by a culture, in those Health Centres with difficult access to laboratory. PMID: 22386535 [PubMed - as supplied by publisher] (Source: Anales de Pediatria)

ACANYA (Clindamycin Phosphate And Benzoyl Peroxide) Gel [Coria Laboratories]

Updated Date: Feb 27, 2012 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>

Is methicillin-resistant Staphylococcus aureus involved in community acquired skin and soft tissue infections?: Experience from a tertiary care centre in Mumbai

Conclusions: In CA SSTIs, methicillin-susceptible S. aureus is the predominant pathogen. Penicillinase-resistant penicillins, clindamycin and erythromycin in that order can be used as suitable antimicrobials for empiric therapy. D test should be carried out routinely. No CA MRSA was detected in the present series. (Source: Journal of Postgraduate Medicine)

Molecular epidemiologic analysis of Staphylococcus aureus isolated from four burn centers

In this study, the prevalent clone of MRSA among four burn centers was found to be SCCmec III (spa-type t030, agr I), which is resistant to 4 kinds of antimicrobials including erythromycin, clindamycin, kanamycin and mupirocin. Discrepancy between mecA detection and conventional tests used for MRSA identification was observed unintentionally. Our data demonstrated that the overall prevalence rate of MRSA was 55.3%, and drugs such as sulfamethoxazole/trimethoprim, linezolid and fusidic acid are efficient antibiotic options for treating S. aureus or MRSA infections among four burn centers studied in present investigation. (Source: Burns : Journal of the International Society for Burn Injuries)

Isolation, speciation, and antibiogram of clinically relevant non-diphtherial Corynebacteria (Diphtheroids)

Conclusion: This study was an attempt to establish the clinical significance of coryneform organisms. The high level of resistance shown by this group to some of the common antibacterial agents highlights the importance of processing these isolates in select conditions to guide the clinicians towards an appropriate therapy. (Source: Indian Journal of Medical Microbiology)

Microbiological Analysis of a Prospective, Randomized, Double-Blind Trial Comparing Moxifloxacin and Clindamycin in the Treatment of Odontogenic Infiltrates and Abscesses (MOCLI Study).

In this study S. anginosus group and hemolytic streptococci were clearly associated with odontogenic abscesses. Our analysis suggests that viridans streptococci and Neisseria spp. have a decisive role in the etiology of odontogenic infiltrates. MXF's high in vitro activity against odontogenic bacteria corresponds well to its clinical results in the treatment of odontogenic abscesses and infiltrates. PMID: 22354306 [PubMed - as supplied by publisher] (Source: Antimicrobial Agents and Chemotherapy)

CLINDAMYCIN (Clindamycin Phosphate) Injection, Solution [Sagent Pharmaceuticals]

Updated Date: Feb 17, 2012 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>

Successful pregnancy in a patient suffering from recurrent mid‚?źtrimester miscarriage with C9 deficiency after receiving cervical cerclage followed by clindamycin and progesterone: A case report

AbstractComplement component 9 (C9) deficiency is relatively common, especially in Japan. Here we present the case of a 27‚?źyear‚?źold Japanese woman whose obstetric history involved three mid‚?źtrimester miscarriages (at 22‚??weeks', 18‚??weeks' and 21‚??weeks' gestation) and one early spontaneous miscarriage. Her fifth pregnancy was successfully managed by cervical cerclage at 13‚??weeks' gestation, followed by clindamycin administration (600‚??mg/day for 7‚??days) and progesterone injections (250‚??mg/week). She gave birth to a healthy 3326‚?źg male infant at 40‚??weeks and 1‚??day gestation after natural onset of labor. After delivery, the serum complement components were analyzed. C9 protein and activity were undetectable in the patient's serum. We suggest that an immunologic disorde...

CLINDAMYCIN HYDROCHLORIDEcapsule [Physicians Total Care, Inc.]

Updated Date: Feb 16, 2012 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

EVOCLIN (Clindamycin Phosphate) Aerosol, Foam [Stiefel Laboratories Inc]

Updated Date: Feb 14, 2012 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

Management of a child with suspected acute septic arthritis

Acute septic arthritis of childhood is a potentially devastating disease that causes permanent disability and can result in death. Traditional treatment consists of a prolonged course of intravenous antibiotics combined with aggressive surgery. However, this approach is challenged by trials showing satisfactory outcomes with shorter treatment and less invasive surgery. Diagnostic arthrocentesis alone and an antibiotic for a fortnight, including initial intravenous administration for 2&ndash;4 days, suffice in most non-neonatal cases. A good penetrating agent, such as clindamycin or a first-generation cephalosporin, exceptionally high doses, and administration four times a day are probably key factors. If the symptoms and signs subside within a few days, and the serum C-reactive protein lev...<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>

Comparison of BD Phoenix and bioM√©rieux Vitek 2 automated systems for the detection of macrolide‚??lincosamide‚??streptogramin B resistance among clinical isolates of Staphylococcus

Abstract: Two automated systems, BD Phoenix and bioMérieux Vitek 2, were compared to a double-disk diffusion method for the detection of inducible resistance to clindamycin in Staphylococcus spp. Analysis of 524 clinical isolates revealed sensitivity and specificity of 100% and 99.6%, respectively, for Phoenix and 91.1% and 99.8%, respectively, for Vitek 2. (Source: Diagnostic Microbiology and Infectious Disease)

Probable Warfarin and Dapsone Interaction

We describe a case of a 41-year-old woman who was stable for over a year on 22.5 mg/week of warfarin. At a follow-up visit, her international normalized ratio (INR) was found to be supratherapeutic at 3.9. Her only significant change was acyclovir initiation for shingles, and clindamycin and dapsone for infection on her right foot. An interaction report was run using Micromedex with no interactions reported. Sixteen percent of the weekly dose was held and maintenance dose was continued. Two weeks later, the INR remained supratherapeutic at 4.3, with discontinuation of clindamycin and dapsone, 5 days earlier, as the only change. This time an interaction report was run using Lexi-Comp, which identified an interaction between warfarin and dapsone. The INR has been therapeutic and stable since...

Group B streptococcal carriage, serotype distribution and antibiotic susceptibilities in pregnant women at the time of delivery in a refugee population on the Thai - Myanmar border

Conclusions: GBS carriage is not uncommon in pregnant women living on the Thai-Myanmar border with a large range of serotypes represented. (Source: BMC Infectious Diseases)

CLINDAMYCIN HYDROCHLORIDEcapsule [Aurobindo Pharma Limited]

Updated Date: Feb 8, 2012 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

The Increased Risk of Community-Acquired Methicillin-Resistant Staphylococcus Aureus in Neck Infections in Young Children

Abstract&nbsp;&nbsp;An increase in the isolation rate of methicillin-resistant Staphylooccus aureus (MRSA) in pediatric deep space neck infections including abscesses has been noted in recent years. A recent study by Duggal et al. [9] analyzed the microbiology of deep neck space in children and identify the possible risk factors. Patients younger than 16&nbsp;months of age were 10 times more likely to have an S. aureus infection as compared to non S. aureus (P‚??&lt;‚??.0001). MRSA comprised the majority of all S. aureus isolates (58%). The majority of community acquired -MRSA (80%) and methicillin sensitive S. aureus isolates (83%) were identified in lateral abscesses in contrast to the non-S. aureus isolates that were located medially (56%). African American pediatric patients accounte...<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>

Valeant Pharmaceuticals Completes Divestiture Of Generic Dermatology Products To Mylan

Valeant Pharmaceuticals International, Inc. (NYSE: VRX and TSX: VRX) today announced that it has completed the divestiture of 1% clindamycin and 5% benzoyl peroxide gel (IDP-111), a generic version of Benzaclin, and 5% fluorouracil cream, (5-FU), an authorized generic of Efudex, to Mylan Inc. (Nasdaq: MYL). (Source: Pharmaceutical Online News)

Multidrug-Resistant, NAP2 Clostridium difficile was the Predominant Toxigenic, Hospital-Acquired Strain in the Province of Manitoba, Canada in 2006-2007.

The objective of the current study was to determine if the antimicrobial susceptibility profile or genotype of hospital-acquired isolates of Clostridium difficile differed from isolates causing community-acquired disease. Five hundred diarrheal stool samples (&gt;2 ml, one sample per patient) from patients across Manitoba, Canada in 2006-2007 that were reported as C. difficile toxin-positive were cultured and resulted in 432 isolates of toxin-positive C. difficile for analysis. Of the 432 isolates, acquisition status could be determined for 235 (54.4%) isolates; 182 (77.4%) were hospital-acquired and 53 (22.6%) were community-acquired. North American Pulsotype (NAP) designations based on SmaI pulsed-field gel electrophoresis could be defined for 52% of the 432 isolates with NAP2 (n = 122) ...

CLINDA-DERM (Clindamycin Phosphate) Solution [Paddock Laboratoratories, LLC]

Updated Date: Feb 1, 2012 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

Acute dacryocystitis in a 2-year old child caused by pantoea.

Authors: Zuberbuhler B, Carifi G, Leatherbarrow B Abstract A previously healthy 23-month-old girl was admitted for the management of an acute unilateral dacryocystitis following accidental contact with dog faeces. No periocular trauma was reported. Microbiological investigation showed a multiresistant strain of Pantoea species to be the responsible pathogen. The infection responded to a course of oral Clindamycin and Ciprofloxacin, in combination with Chloramphenicol eye drops. This is the first report of an acute dacryocystitis sustained by this microorganism. PMID: 22296230 [PubMed - in process] (Source: Orbit)

[Antibiotic-impregnated catheters. A useful tool against infection].

Authors: Gutiérrez-González R Abstract Progress in the treatment of hydrocephalus and particularly of cerebrospinal fluid (CSF) diversion surgery has been continuous and significant from cranial bandaging, which was one of the initial hydrocephalus treatments in the 16th century, to last-generation CSF shunts. However, infection currently remains the most frequent and serious complication despite the efforts made to prevent it. One of these current prevention measures is the use of antibiotic-impregnated catheters. A retrospective cohort study including shunts and external ventricular drains was designed to assess their efficacy in our scenario. The results show that rifampicin- and clindamycin-impregnated catheters are a helpful tool against CSF shunt-derived infection. PMID...<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>

Pneumocystis jiroveci pneumonia in patients with systemic lupus erythematosus after rituximab therapy.

We report PCP in two patients with SLE after rituximab treatment. Fever and respiratory symptoms associated with diffuse pulmonary infiltrates developed within weeks after rituximab therapy. One patient died of respiratory failure. Another patient recovered uneventfully after treatment with clindamycin and primaquine. PMID: 22287506 [PubMed - as supplied by publisher] (Source: Lupus)

Bath salts and necrotizing fasciitis: a case report

3 out of 5 stars Life-threatening Necrotizing Fasciitis Due to &#8216;Bath Salts&#8217; Injection. Russo R et al. Orthopedics 2012 Jan 16;35(1):e124-7. doi: 10.3928/01477447-20111122-36. Abstract This dramatic case report fro Louisiana State University Health Sciences Center describes a 34-year-old woman who developed a rapidly progressing necrotizing fasciitis several days after injecting a &#8220;bath salt&#8221; product intramuscularly into the right forearm. The authors report that the infection was so virulent that: &#8220;In the time it took to expose the anterior upper arm, muscle in the forearm that had previously been contractile and pink had turned dusky and noncontractile.&#8221; In the effort to debride necrotic tissue and establish clean margins, the surgeons performed a fore...

Antimicrobial Resistance in Campylobacter spp. Isolated from Ontario Sheep Flocks and Associations between Antimicrobial use and Antimicrobial Resistance

The objectives of this study were to determine the prevalence of antimicrobial resistance (AMR) in faecal Campylobacter spp. from lambs and adult sheep and associations between antimicrobial use (AMU) and AMR. A total of 275 faecal samples collected during initial and final visits from 51 sheep flocks, including one feedlot, across southern Ontario were tested for the presence of Campylobacter spp. Campylobacter jejuni was detected in 52% (143/275) of the faecal samples, Campylobacter coli in 7% (19/275), Campylobacter lari in 1% (2/275) and 2% (4/275) were non‚?źspeciated Campylobacter. Broth microdilution was used to test antimicrobial susceptibility of 162 isolates to nine antimicrobials. Campylobacter jejuni isolates (n‚??=‚??142) were resistant to tetracycline (39%), ciprofloxacin (4%...

Antimalarials/clindamycin/dexamethasone: Zygomycosis (first report with dapsone, pyrimethamine and clindamycin) and pancytopenia: case report

(Source: Reactions)<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>

Clindamycin: Clostridium difficile pancolitis in a child, treated with mesalazine: case report

(Source: Reactions)

Inhibition of Propionibacterium acnes lipase by extracts of Indian medicinal plants

This study reports for the first time the novel antilipase activity of chebulagic acid (IC50: 60 őľM) with MIC value of 12.5 őľg mL‚??1 against P. acnes.The inhibitory potential of plant extracts was further confirmed by plate assay. The organism was grown in the presence of subinhibitory concentrations of extracts from P. kurroa, V. negundo, T. chebula, E. ribes and antibiotics such as clindamycin and tetracycline. Extract from T. chebula showed significant inhibition of lipase activity and number of P. acnes.¬© 2012 The Authors ICS ¬© 2012 Society of Cosmetic Scientists and the Soci√©t√© Fran√ßaise de Cosm√©tologie (Source: International Journal of Cosmetic Science)

Effect of Peritoneal Lavage with Clindamycin-Gentamicin Solution on Infections after Elective Colorectal Cancer Surgery

Conclusions: Antibiotic lavage of the peritoneum is associated with a lower incidence of intra-abdominal abscesses and wound infections. (Source: Journal of the American College of Surgeons)

Single Dose of Antibiotic Leaves Mice Highly Vulnerable to Intestinal Infection

Yet another study adds to the growing evidence that antibiotics can disrupt the balance of the intestinal flora, with negative effects on health. A team of researchers from the Memorial Sloan Kettering Cancer Center, New York City, has shown in mouse models that a single dose of the commonly used antibiotic, clindamycin, wiped out nearly 90 percent of bacterial taxa, leaving the mice unusually susceptible to infection by Clostridium difficile. Read more... (Source: American Society for Microbiology)

DUAC (Clindamycin Phosphate And Benzoyl Peroxide) Gel [Stiefel Laboratories Inc]

Updated Date: Jan 19, 2012 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>

CLINDAMYCIN HYDROCHLORIDEcapsule [Lannett Company, Inc.]

Updated Date: Jan 18, 2012 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

The Role of Rifampin against Propionibacterium acnes Biofilm in vitro and in an Experimental Foreign-Body Infection Model.

Authors: Furustrand Tafin U, Corvec S, Betrisey B, Zimmerli W, Trampuz A Abstract Propionibacterium acnes is an important cause of orthopedic implant-associated infections, for which the optimal treatment has not yet been determined. We investigated the activity of rifampin, alone and in combination, against planktonic and biofilm P. acnes in vitro and in a foreign-body infection model. The MIC and the minimal bactericidal concentration (MBC) were 0.007 and 4 őľg/ml for rifampin, 1 and 4 őľg/ml for daptomycin, 1 and 8 őľg/ml for vancomycin, 1 and 2 őľg/ml for levofloxacin, 0.03 and 16 őľg/ml for penicillin G, 0.125 and 512 őľg/ml for clindamycin, and 0.25 and 32 őľg/ml for ceftriaxone, respectively. The P. acnes minimal biofilm eradication concentration (MBEC) was 16 őľg/ml for rif...

Pharmacokinetics of Clindamycin in the Plasma and Dialysate after Intraperitoneal Administration of Clindamycin Phosphoester to Patients on Continuous Ambulatory Peritoneal Dialysis: An Open‚?źLabel, Prospective, Single‚?źDose, Two‚?źInstitution Study

Abstract:‚?? We evaluated the pharmacokinetics of clindamycin and the dose of clindamycin phosphate necessary to treat peritonitis after intraperitoneal administration of clindamycin phosphate to patients on continuous ambulatory peritoneal dialysis (CAPD). This was an open‚?źlabel, prospective, single‚?źdose study conducted at the two levels of institutional clinical care in South Korea. Twelve patients (six men and six women; all older than 25‚??years), mean CAPD duration of 38.2‚??months with various origins without peritonitis, received 600‚??mg clindamycin phosphate mixed with only the first 2‚?źL dialysate (1.5% dextrose). The 1.5%, 1.5%, 2.5% and 1.5% dextrose dialysates were serially exchanged every 6‚??hr. If patients were non‚?źanuric, 24‚?źhr urine samples were also collected. C...

Comparison of the Effects of Human ő≤-defensin 3, Vancomycin, and Clindamycin on Staphylococcus aureus Biofilm Formation.

Authors: Huang Q, Yu HJ, Liu GD, Huang XK, Zhang LY, Zhou YG, Chen JY, Lin F, Wang Y, Fei J Abstract Despite improvements in surgical techniques and implant design in orthopedic surgery, implantation-associated infections are still a challenging problem for surgeons. In 2006, trace quantities of human ő≤-defensin 3 (hBD-3) were found in human bone tissue and bone cells. Human ő≤-defensin 3 is a 45-amino-acid peptide that is considered the most promising class of defensin antimicrobial peptides and may help in the prevention and treatment of implantation-associated infections. Studies of the effectiveness of hBD-3 against Staphylococcus aureus showed that hBD-3 was more potent at low concentrations than other antibiotics. The effect of hBD-3 on S aureus biofilms has not been reporte...

Prevalence, characterization and antimicrobial resistance of Listeria monocytogenes isolated from bovine hides and carcasses.

Authors: Wieczorek K, Dmowska K, Osek J Abstract L. monocytogenes isolated from bovine hides and carcasses (n = 812) were mainly of serogroup 1/2a. All strains were positive for internalin genes. Several isolates (72.2%) were resistant to oxacillin or clindamycin (37.0%). These findings indicate that L. monocytogenes of beef origin can be considered as a public health concern. PMID: 22247138 [PubMed - as supplied by publisher] (Source: Applied and Environmental Microbiology)<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>

CLINDAMYCIN HYDROCHLORIDEcapsule [Ranbaxy Pharmaceuticals Inc.]

Updated Date: Jan 12, 2012 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

Group B Streptococcus infections in non-pregnant adults: the role of immunosuppression

Conclusions: GBS, previously considered a genitourinary pathogen, has emerged as a non-nosocomial opportunistic pathogen causing BSI, endocarditis, and CNS infections. Immunosuppression, particularly transient immunosuppressed states, was an independent predictor for GBS BSI. Resistance rates to macrolides and clindamycin continue to increase, and should be closely monitored. (Source: International Journal of Infectious Diseases)

Susceptibility trends of Bacteroides fragilis group and characterisation of carbapenemase-producing strains by automated REP-PCR and MALDI TOF.

Authors: Trevi√Īo M, Areses P, Dolores Pe√Īalver M, Cortizo S, Pardo F, Luisa P√©rez Del Molino M, Garc√≠a-Riestra C, Hern√°ndez M, Llovo J, Regueiro BJ Abstract Susceptibility testing of clinical isolates of anaerobic bacteria is not considered, often, mandatory in routine clinical practice and the treatments are empirically established. Thus, periodic monitoring of the susceptibility patterns of anaerobic bacteria is advisable. The aim of this study was to update on resistance of Bacteroides fragilis group in our Institution with special attention to carbapenems reporting metallo-beta-lactamase producing strains for the first time in Spain, and to compare fingerprinting analysis results obtained by using automated rep-PCR (DiversiLab System) and MALDI-TOF MS. A total of 830 non-d...

First National Survey of Antibiotic Susceptibility of the Bacteroides fragilis Group: Emerging Resistance to Carbapenems in Argentina.

Authors: Fern√°ndez-Canigia L, Litterio M, Legaria MC, Castello L, Predari SC, Di Martino A, Rossetti A, Rollet R, Carloni G, Bianchini H, Cejas D, Radice M, Gutkind G, Abstract The susceptibility rates of 363 clinical Bacteroides fragilis group isolates collected from 17 centers in Argentina during the period 2006-2009 were as follows: piperacillin-tazobactam 99 %, ampicillin-sulbactam 92 %, cefoxitin 72 %, tigecycline 100 %, moxifloxacin 91 %, clindamycin 52 %, and no metronidazole resistance was detected. Resistance to imipenem, doripenem and ertapenem was observed in 1.1 %, 1.6 % and 2.3 % of B. fragilis group strains, respectively. B. fragilis species showed a resistance profile of 1.5 % to imipenem, 1.9 % to doripenem and 2.4 % to ertapenem, being the first report of carbape...

Evaluation of MBEC‚?Ę‚?źHTP biofilm model for studies of implant associated infections

In this study we evaluated the Minimum Biofilm Eradication Concentration‚?źHigh Throughput Plates (MBEC‚?Ę‚?źHTP) as biofilm in vitro model for studies of implant associated infections. Staphylococcus aureus and Staphylococcus epidermidis biofilms were grown on MBEC‚?Ę‚?źHTP. To ensure the biofilm formation, antibiotic susceptibility tests and scanning electron microscopy (SEM) was carried out. Susceptibility tests were carried out using gentamicin, vancomycin, rifampicin, fosfomycin, clindamycin, and linezolid. Colony forming units counting were carried out. Minimal inhibitory concentration (MIC) and biofilm inhibitory concentration (BIC) were estimated. The CFU counting showed potency of rifampicin and daptomycin against S. epidermidis biofilms and rifampicin against S. aureus biofilms. ...<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>

CLINDAMYCIN HYDROCHLORIDEcapsule [Lake Erie Medical DBA Quality Care Products LLC]

Updated Date: Jan 5, 2012 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

Consider Antibiotics, Laser Surgery for Hidradenitis SuppurativaConsider Antibiotics, Laser Surgery for Hidradenitis Suppurativa

Clindamycin with either carbon dioxide or Nd:YAG laser treatments should be considered first-line therapies for mild-to-moderate hidradenitis suppurativa. Reuters Health Information (Source: Medscape Dermatology Headlines)

Clindamycin plus quinine for treating uncomplicated falciparum malaria: a systematic review and meta-analysis

The evidence on the efficacy of clindamycin plus quinine as an alternative treatment for uncomplicated malaria is inconclusive. Adequately powered trials are urgently required to compare this combination with artemisinin-based combinations. (Source: Malaria Journal)

Phenotypes and genotypes of erythromycin-resistant Streptococcus pyogenes strains isolated from invasive and non-invasive infections from Mexico and the USA during 1999‚??2010

Conclusions: Erythromycin resistance continues to exist at low levels in both Mexico and the USA, although the genetic mechanisms responsible differ between the two nations. These genetic differences may be related to the invasive character of the S. pyogenes isolated. (Source: International Journal of Infectious Diseases)<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>

Delayed-onset infections after impacted lower third molar extraction: involved bacteria and sensitivity profiles to commonly used antibiotics

Conclusions: Fusobacterium sp., Prevotella sp., and Peptostreptococcus sp. are frequently present in delayed-onset infections after lower third molar removal. Based on the results of the microbial susceptibility tests, clindamycin seems to be the most adequate antibiotic for the treatment of this complication. (Source: Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontics)

Consider antibiotics, laser surgery for hidradenitis suppurativa, review suggests

NEW YORK (Reuters Health) - Clindamycin with either carbon dioxide or Nd:YAG laser treatments should be considered first-line therapies for mild-to-moderate hidradenitis suppurativa (HS), according to a new review of treatments for the rare disease. (Source: Modern Medicine)

Cochrane Review: Different antibiotic treatments for group A streptococcal pharyngitis

AbstractBackgroundAntibiotics provide only modest benefit in treating sore throat, although effectiveness increases in participants with positive throat swabs for group A beta‚?źhaemolytic streptococci (GABHS). It is unclear which antibiotic is the best choice if antibiotics are indicated.ObjectivesWe assessed the comparative efficacy of different antibiotics on clinical outcomes, relapse, complications and adverse events in GABHS tonsillopharyngitis.Search methodsWe searched The Cochrane Library, Cochrane Central Register of Controlled Trials (CENTRAL 2010, Issue 3) which includes the Acute Respiratory Infections Group's Specialised Register, MEDLINE (1966 to July Week 4, 2010) and EMBASE (1974 to August 2010).Selection criteriaRandomised, double‚?źblind trials comparing different antibio...

Comparative Effectiveness of Antibiotic Treatment Strategies for Pediatric Skin and Soft-tissue Infections: Williams DJ, Cooper WO, Kaltenbach LA, et al. Pediatrics 2011;128:479‚??87.

This was a retrospective cohort study of 47,501 children aged 0‚??17 years comparing the effectiveness of treatment with trimethoprim-sulfamethoxazole (TMP-SMX) or a ő≤-lactam vs. clindamycin in drained and undrained skin and soft-tissue infections (SSTI). Children with an SSTI and prescription for either clindamycin (reference treatment), trimethoprim-sulfamethoxazole, or a ő≤-lactam (penicillin or cephalosporin) filled within 2 days of the SSTI were included in the study and grouped based on drainage status. Exclusion criteria included: SSTI within the last 365 days, treatment with multiple agents, treatment with topical antibiotics, SSTI requiring hospital admission, burns, foreign bodies, or surgical-site infections. Effectiveness of each antibiotic therapy was defined with respect to ...

BENZACLIN (Clindamycin Phosphate And Benzoyl Peroxide) Gel [Physicians Total Care, Inc.]

Updated Date: Dec 28, 2011 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>

CLINDAMYCIN HYDROCHLORIDEcapsule [American Health Packaging]

Updated Date: Dec 27, 2011 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

Prevalence of Antimicrobial Resistance among Clinical Isolates of Bacteroides fragilis group in Canada in 2010-2011: CANWARD Surveillance Study.

Authors: Karlowsky JA, Walkty AJ, Adam HJ, Baxter MR, Hoban DJ, Zhanel GG Abstract Clinical isolates of Bacteroides fragilis group (n = 387) were collected from patients attending nine Canadian hospitals in 2010-2011 and tested for susceptibility to 10 antimicrobial agents using the Clinical and Laboratory Standards Institute (CLSI) broth microdilution method. B. fragilis (59.9%), Bacteroides ovatus (16.3%), and Bacteroides thetaiotamicron (12.7%) accounted for ‚?ľ90% of isolates collected. Overall rates of percent susceptibility were: 99.7%, metronidazole; 99.5%, piperacillin-tazobactam; 99.2% imipenem; 97.7%, ertapenem; 92.0%, doripenem; 87.3%, amoxicillin-clavulanate; 80.9%, tigecycline; 65.9%, cefoxitin; 55.6%, moxifloxacin; and 52.2%, clindamycin. Percent susceptibility to cef...

A Comparison of Dequalinium Chloride Vaginal Tablets (Fluomizin¬ģ) and Clindamycin Vaginal Cream in the Treatment of Bacterial Vaginosis: A Single-Blind, Randomized Clinical Trial of Efficacy and Safety

(Source: Gynecologic and Obstetric Investigation)

Microbiology of regressive autism.

Authors: Finegold SM, Downes J, Summanen PH Abstract This manuscript summarizes some of our earlier work on the microbiology of autism subjects' stool specimens, as compared with stools from control subjects. Our most recent data indicating that Desulfovibrio may play an important role in regressive autism is also presented. In addition, we present information on antimicrobial susceptibility patterns of Desulfovibrio using the CLSI agar dilution susceptibility technique. In addition, we summarize data from our earlier studies showing the impact of various antimicrobial agents on the indigenous bowel flora. This shows that penicillins and cephalosporins, as well as clindamycin, have a major impact on the normal bowel flora and therefore might well predispose subjects to overgrowth o...

CLINDAMYCIN HYDROCHLORIDEcapsule [PD-Rx Pharmaceuticals, Inc.]

Updated Date: Dec 20, 2011 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>

A Systematic Review of Treatments for Hidradenitis Suppurativa [Study]

Conclusions&nbsp; Shown to be effective treatments for HS were a clindamycin-rifampin combination regimen, a course of infliximab, monthly Nd:YAG laser sessions, and surgical excision and primary closure with a gentamicin sulfate&ndash;collagen sponge. Most therapies used to treat HS were supported by limited or weak scientific evidence. A treatment approach is presented based on the evidence and on clinical experience at the Follicular Disorders Clinic, Department of Dermatology, Henry Ford Hospital, Detroit, Michigan. This review emphasizes the need for large randomized controlled trials to evaluate treatment options for HS. (Source: Archives of Dermatology)

Methicillin-Resistant Staphylococcus aureus Colonization in Otitis-Prone Children [Original Article]

Conclusions&nbsp; The prevalence of MRSA colonization among otitis-prone children was similar to rates reported among the general pediatric community. Methicillin-resistant S aureus colonization at the time of bilateral myringotomy and tube insertion was not predictive of subsequent otorrhea. (Source: Archives of Otolaryngology)

Methicillin-Resistant Staphylococcus aureus Ocular Infection: A 10-Year Hospital-Based Study

Conclusions: Community-associated MRSA is an important pathogen of ocular infections; CA-MRSA and HA-MRSA ocular infections differ demographically and clinically, but both strains were multi-resistant in Chang Gung Memorial Hospital, one of the biggest referral centers in Taiwan. In a country with a high prevalence of MRSA, ophthalmologists should be aware of such epidemiologic information. Financial Disclosure(s): The author(s) have no proprietary or commercial interest in any materials discussed in this article. (Source: Ophthalmology)

BENZACLIN (Clindamycin Phosphate And Benzoyl Peroxide) Gel [Dermik Laboratories]

Updated Date: Dec 15, 2011 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

First Report of Methicillin-Resistant Staphylococcus aureus ST5 and ST398 from Purebred Lusitano Horses

Abstract: Methicillin-resistant Staphylococcus aureus (MRSA) was first described in horses in 1996. The frequency of MRSA colonization in horses varies among European countries, but it is unknown in Portugal. The aim of this study was to screen for MRSA nasal carriage in a sample of horses entering the Equine Unit, Large Animal Veterinary Teaching Hospital of the Faculty of Veterinary Medicine, Lisbon, Portugal. Seventy-one horses were swabbed, and MRSA was identified by selective isolation on a chromogenic medium. Two S aureus isolates showed resistance to oxacillin (minimum inhibitory concentration >4¬†őľg/mL) and contained the mecA gene. Both strains were isolated from purebred Lusitano horses that lived in farms with more than 20 equines. These MRSA strains represented two different cl...<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>

ICEPmu1, an integrative conjugative element (ICE) of Pasteurella multocida: analysis of the regions that comprise 12 antimicrobial resistance genes

Conclusions The observation that 12 resistance genes, organized in two resistance gene regions, represent part of an ICE in P. multocida underlines the risk of simultaneous acquisition of multiple resistance genes via a single horizontal gene transfer event. (Source: Journal of Antimicrobial Chemotherapy)

Concentration-dependent effects of antimicrobials on Staphylococcus aureus toxin-mediated cytokine production from peripheral blood mononuclear cells

Conclusions S. aureus toxins stimulate production of inflammatory cytokines in PBMCs. Antimicrobials with high tissue penetration, including tigecycline, clindamycin, trimethoprim/sulfamethoxazole and linezolid, reduced cytokine production, which, along with their antimicrobial effects, may have importance in the therapeutic outcome of severe infections. (Source: Journal of Antimicrobial Chemotherapy)

Characterization of Nares and Blood Culture Isolates of Methicillin-resistant Staphylococcus aureus from Patients in United States Hospitals.

Authors: Tenover FC, Tickler IA, Goering RV, Kreiswirth BN, Mediavilla JR, Persing DH, Abstract A total of 299 nares and 194 blood isolates of methicillin-resistant Staphylococcus aureus (MRSA), each recovered from a unique patient, were collected from 23 U.S. hospitals from May 2009 to March 2010. All isolates underwent spa and SCCmec typing and antimicrobial susceptibility testing; a subset of 84 isolates was typed by pulsed-field gel electrophoresis using SmaI. Seventy-six spa types were observed among the isolates. Overall, for nasal isolates, spa type t002/SCCmec type II (USA100) was the most common strain type (37% of isolates), while among blood isolates, spa type t008/SCCmec type IV (USA300) was the most common (39%). However, the proportion of all USA100 and USA300 isolat...

Pharmacokinetics of Clindamycin in the Plasma and Dialysate After Intraperitoneal Administration of Clindamycin Phosphoester to Patients on Continuous Ambulatory Peritoneal Dialysis: An Open‚?źLabel, Prospective, Single‚?źDose, Two‚?źInstitution Study

AbstractWe evaluated the pharmacokinetics of clindamycin and the dose of clindamycin phosphate necessary to treat peritonitis after intraperitoneal administration of clindamycin phosphate to patients on CAPD. This was an open‚?źlabel, prospective, single‚?źdose study conducted at the two levels of institutional clinical care in South Korea. Twelve patients (six male, six female; all older than 25 years), mean CAPD duration of 38.2 months with various origins without peritonitis received 600 mg clindamycin phosphate mixed with only the first 2‚?źL dialysate (1.5% dextrose). The 1.5, 1.5, 2.5 and 1.5% dextrose dialysates were serially exchanged every 6 hr. If patients were non‚?źanuric, 24‚?źhr urine samples were also collected. Clindamycin phosphate was incompletely activated to clindamycin...

[Chronic subdural hematoma infected by Campylobacter fetus: Case report.]

We report here a rare case of chronic subdural hematoma infected by Campylobacter fetus in a 86-year-old woman. She was admitted for confusion and disorientation in a context of high fever and diarrhoea. After two surgeries, the evolution was finally good with a combination of antibiotics (amoxicillin and clindamycin). Chronic subdural hematoma is a potential site for bacterial infection. Our case suggests that C. fetus infection should be suspected in elderly patients presenting with fever and enteritis. The frequency of such cases may be underestimated, due to the difficult diagnosis of C. fetus. It is also suspected that C. fetus could play a role in the recurrence of hematoma, because of its vessel tropism. PMID: 22154423 [PubMed - as supplied by publisher] (Source: Neuro-Chirur...<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>

A mechanistic study on the effect of ethanol and importance of water on permeation of drugs through human third‚?źdegree burn eschar

In this study, permeations of clindamycin phosphate (CP, hydrophilic) and diazepam (lipophilic) through human burn eschar were investigated in the presence and absence of ethanol. Permeability coefficients (Kp) of CP and diazepam through hydrated eschar were calculated to be 13¬∑1 √? 10‚??3 and 17¬∑4 √? 10‚??3 cm/h respectively. These Kp values were decreased by about 1¬∑5‚??5¬∑3 and 2‚??10¬∑7 times respectively upon the addition of 20‚??70% ethanol. Increased amount of ethanol decreased permeation flux of CP (2‚??20 times) and increased that of diazepam (3‚??80 times) from saturated solutions. Thermal analysis showed that ethanol dehydrates eschar and also changes its internal proteineous structure. Such changes were concluded to be the main reasons behind decreased Kp of both drugs. Comp...

High rates of perinatal Group B Streptococcus clindamycin and erythromycin resistance in an Upstate NY hospital.

CONCLUSION:Rates of GBS resistance to clindamycin and erythromycin are much higher than reported in earlier US studies, suggesting both increasing resistance as well as regional variation in resistance. These findings lend strong support to the CDC and ACOG recommendations that clindamycin use for intrapartum antibiotic prophylaxis be restricted to penicillin allergic women at high risk of anaphylaxis and that GBS isolates be tested for antibiotic resistance prior to the use of clindamycin in these women. PMID: 22143529 [PubMed - as supplied by publisher] (Source: Antimicrobial Agents and Chemotherapy)

The Timing of Antibiotics at Cesarean: A Randomized Controlled Trial

Amer J PerinatolDOI: 10.1055/s-0031-1295657We compared maternal and neonatal outcomes in women who received prophylactic antibiotics prior to skin incision to those who received antibiotics at cord clamp. We performed a randomized clinical trial at two sites. Eligible women included those undergoing nonemergency cesarean at 36 weeks‚?? gestation or greater. Subjects were randomized (permuted blocks) into one of two treatments: ‚??preoperative antibiotics‚?Ě (cefazolin 1 g given &lt;30 minutes prior to skin incision) or ‚??intraoperative antibiotics‚?Ě (cefazolin 1 g at cord clamping). Patients who reported an allergy to penicillin received clindamycin 900 mg. The trial primary outcome was a composite of maternal infectious morbidities, defined as having any one of the following: (1) postop...

A mechanistic study on the effect of ethanol and importance of water on permeation of drugs through human third‚?źdegree burn eschar

In this study, permeations of clindamycin phosphate (CP, hydrophilic) and diazepam (lipophilic) through human burn eschar were investigated in the presence and absence of ethanol. Permeability coefficients (Kp) of CP and diazepam through hydrated eschar were calculated to be 13¬∑1 √? 10‚??3 and 17¬∑4 √? 10‚??3 cm/h respectively. These Kp values were decreased by about 1¬∑5‚??5¬∑3 and 2‚??10¬∑7 times respectively upon the addition of 20‚??70% ethanol. Increased amount of ethanol decreased permeation flux of CP (2‚??20 times) and increased that of diazepam (3‚??80 times) from saturated solutions. Thermal analysis showed that ethanol dehydrates eschar and also changes its internal proteineous structure. Such changes were concluded to be the main reasons behind decreased Kp of both drugs. Comp...

Bacteroides mobilizable and conjugative genetic elements: antibiotic resistance among clinical isolates.

Authors: Quesada-Gómez C Abstract The conjugation is one of the most important mechanisms of horizontal gene transfer in prokaryotes, leading to genetic variation within a species and the acquisition of new traits, such as antibiotic resistance. Bacteroides is an obligate anaerobe of the colon and a significant opportunistic pathogen. Antibiotic resistance among Bacteroides spp. is rapidly increasing, largely due to the dissemination of DNA transfer factors (plasmids and transposons) harbored by members of this genus. Transfer factors can be divided into two classes, conjugative and mobilizable. Species of the intestinal Bacteroides have yielded different resistance plasmids, all of which have been intensely studied, the plasmids encode high-level MLS resistance conferred by a con...<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>

The genetic diversity and phenotypic characterisation of Streptococcus agalactiae isolates from Rio de Janeiro, Brazil.

In this study, we evaluate the genetic and phenotypic diversity in S. agalactiae strains from Rio de Janeiro (RJ) that were isolated from asymptomatic carriers. We analysed these S. agalactiae strains using pulsed-field gel electrophoresis (PFGE), serotyping and antimicrobial susceptibility testing, as well as by determining the macrolide resistance phenotype, and detecting the presence of the ermA/B, mefA/E and lnuB genes. The serotypes Ia, II, III and V were the most prevalent serotypes observed. The 60 strains analysed were susceptible to penicillin, vancomycin and levofloxacin. Resistance to clindamycin, chloramphenicol, erythromycin, rifampin and tetracycline was observed. Among the erythromycin and/or clindamycin resistant strains, the ermA, ermB and mefA/E genes were detected and th...

[Bacterial meningitis].

Conclusions: Although the incidence of group A streptococcal meningitis seems to be low, invasive infection by this agent is raising. Despite the excellent evolution of this case, a fatal outcome or neurological sequelae can arise, even in healthy children. PMID: 22856400 [PubMed - in process] (Source: Acta Medica Portuguesa)

In vitro interaction of usnic acid in combination with antimicrobial agents against methicillin-resistant Staphylococcus aureus clinical isolates determined by FICI and ő?E model methods

Abstract: The in vitro antimicrobial activities of usnic acid were evaluated in combination with five therapeutically available antibiotics, using checkerboard microdilution assay against methicillin-resistant clinical isolates strains of Staphylococcus aureus. MIC90, MIC50, as well as MBC90 and MBC50, were evaluated. A synergistic action was observed in combination with gentamicin, while antagonism was observed with levofloxacin. The combination with erythromycin showed indifference, while variability was observed for clindamycin and oxacillin. Data from checkerboard assay were analysed and interpreted using the fractional inhibitory concentration index (FICI) and the response surface approach using the ő?E model. Discrepancies were found between both methods for some combinations. These ...

Itching to know the diagnosis: Category: Lesson in Microbiology & Infection Control

A normally healthy 22 year old male presented to our hospital with a two day history of unbearably itchy hands and feet. Although this was his main complaint, he had also noticed the development of a widespread rash over the last 24 hours and had been feverish with rigors overnight. He additionally complained of a mild sore throat, and of a chronic "ingrown hair" at the natal cleft which had become more painful recently. On examination, he had a 3cm wide pilonidal abscess. A macular blanching rash was present on the patient's hands, feet, forearms, and abdomen. Despite complaining of a sore throat, his throat looked normal. Observations taken in A&E showed that he was pyrexial and tachycardic. At this point, his rash was thought to be viral in nature, but in view of his sepsis he was comme...

A lingual abscess caused by Streptococcus intermedius.

We describe a case in a healthy female with no recent history of trauma. The organism recovered by culture of drainage material collected prior to antibiotic treatment was Streptococcus intermedius, an organism recognized as flora of the oropharynx and associated with abscess formation. The isolate was resistant to clindamycin, which was the antibiotic therapy that the patient received. PMID: 22116986 [PubMed - as supplied by publisher] (Source: Journal of Medical Microbiology)<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>

Antibiotic‚?źresistant Propionibacterium acnes among acne patients in a regional skin centre in Hong Kong

Conclusions‚?? Antibiotic‚?źresistant P. acnes is prevalent in Hong Kong. Dermatologists should be more vigilant in prescribing antibiotics for acne patients. (Source: Journal of the European Academy of Dermatology and Venereology)

Preliminary safety evaluation of a new Bacteroides xylanisolvens strain.

Authors: Ulsemer P, Toutounian K, Schmidt J, Karsten U, Goletz S Abstract Besides conferring some health benefit to the host, a bacterial strain to be considered as a probiotic must present an unambiguous safety status. We here present the preliminary safety evaluation of a new Bacteroides xylanisolvens strain (DSM 23964) isolated from human feces. First results suggest that it may be able to provide probiotic health benefits. Its identity was confirmed by biochemical analysis, sequencing of its 16S rRNA genes, and by DNA-DNA hybridization. Virulence determinants known to occur in the genus Bacteroides, such the bft enterotoxin and other enzymatic activities involved in the degradation of the extracellular matrix and the capsular polysaccharide PS A were absent in this strain. The ...

Efficacy and safety of topical nadifloxacin and benzoyl peroxide versus clindamycin and benzoyl peroxide in acne vulgaris: A randomized controlled trial

Conclusions: Topical nadifloxacin, a new fluoroquinolone is effective, tolerable, and safe for mild o moderate facial acne. Its clinical effectiveness is comparable to clindamycin when used as add-on therapy to benzoyl peroxide. (Source: Indian Journal of Pharmacology)

Bacterial Vaginosis, Atopobium Vaginae and Nifuratel.

Authors: Polatti F Abstract As bacterial vaginosis (BV) is a potential cause of obstetric complications and gynecological disorders, there is substantial interest in establishing the most effective treatment. Standard treatment - metronidazole or clindamycin, by either vaginal or oral route - is followed by relapses in about 30% of cases, within a month from treatment completion. This inability to prevent recurrences reflects our lack of knowledge on the origins of BV. Atopobium vaginae has been recently reported to be associated with BV in around 80% of the cases and might be involved in the therapeutic failures. This review looks at the potential benefits of nifuratel against A. vaginae compared to the standard treatments with metronidazole and clindamycin. In vitro, nifuratel is...<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>

CLINDAMYCIN HYDROCHLORIDEcapsule [Preferred Pharmaceuticals, Inc]

Updated Date: Nov 9, 2011 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

CLINDAMYCIN HYDROCHLORIDEcapsule, Gelatin Coated [Preferred Pharmaceuticals, Inc]

Updated Date: Nov 9, 2011 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

Simulated antibiotic exposures in an in vitro hollow fiber infection model influence toxin gene expression and production in community-associated MRSA strain MW2.

Conclusion:Linezolid, clindamycin and minocycline were the most effective agents on decreasing the virulence potential in CA-MRSA, notably after 8h of treatment. SXT had minimal effects on toxin gene regulation, but it increased production and cytotoxicity of PVL toxin in the model and may enhance virulence when treating severe infections. PMID: 22064533 [PubMed - as supplied by publisher] (Source: Antimicrobial Agents and Chemotherapy)

Comparative pharmacokinetics study of two different clindamycin capsule formulations: a randomized, two-period, two-sequence, two-way crossover clinical trial in healthy volunteers.

Authors: Sanki UK, Mandal BK, Chandrakala V Abstract The comparative pharmacokinetic (PK) study of two brands of clindamycin hydrochloride (CAS 21462-39-5) was carried out on 32 healthy Indian subjects in an open label randomized, two way crossover, two period, two sequence, two treatment trial with a minimum washout period of 7 days. Plasma samples were collected at 10 min interval for the 1st hour, at 1 h interval for the next 6 h, at 2 h interval for next 12 h and finally at the 24th hour (pre-dose as baseline value) after drug administration. The concentrations of clindamycin in plasma were determined using high performance liquid chromatography (HPLC) technique with UV detector [lower limit of quantitation (LLOQ) 0.05 microg x mL(-1)). All PK parameters were calculated from da...

Increasing antibiotic resistance in Streptococcus pneumoniae colonizing children attending day‚?źcare centres in Singapore

Conclusions:‚??S.‚??pneumoniae antibiotic resistance has risen dramatically over the last 10‚??years in Singapore. Wider conjugate vaccine uptake and improved antibiotic stewardship should be made priorities. Surveillance of sentinel sites like day‚?źcare centres provides important data with respect to shifts in pneumococcal ecology. (Source: Respirology)<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>

Severe Myositis Associated with Sarcocystis spp. Infection in 2 Dogs

Conclusions and Clinical ImportanceSarcocystis spp. infection should be included in the differential diagnosis for dogs that develop fever, thrombocytopenia, increased liver enzyme activities, and clinical and biochemical evidence of myositis. Although additional studies are required, decoquinate holds promise as an effective treatment for the disease. (Source: Journal of Veterinary Internal Medicine)

Antimicrobial Drug Resistance in Corynebacterium diphtheriae mitis.

Authors: Barraud O, Badell E, Denis F, Guiso N, Ploy MC Abstract To the Editor: Corynebacterium diphtheriae is the agent of pharyngeal and cutaneous diphtheria. We did a retrospective analysis of the antimicrobial drug susceptibilities of 46 C. diphtheriae isolates sent during 1993 through 2010 to the French National Reference Centre of Toxigenic Corynebacteria. The isolates came from metropolitan France and French overseas departments and territories. Only 1 isolate, C. diphtheriae biovar mitis, FRC24, expressed the following antimicrobial drug susceptibility profile: susceptible to penicillin, amoxicillin, ciprofloxacin, clindamycin, erythromycin, gentamicin, imipenem, kanamycin, rifampin, tetracycline, and vancomycin and resistant at an uncommonly high level to trimethoprim, sul...

Rapidly enlarging nodular lesion of the anterior maxilla

A 25-year-old Hispanic male was referred to our hospital oral surgery clinic from a local correctional facility for the evaluation of an oral mass. The patient's chief complaint was a painless, rapidly enlarging swelling of his gingiva of the right anterior maxilla. It was first noticed approximately 8 weeks prior and described by the patient as a small bump between the maxillary right canine and maxillary right lateral incisor teeth. Progressive mobility of his right maxillary anterior teeth and slight drainage were reported. Before referral for lesion evaluation, the patient was treated with oral clindamycin 300 mg, 3 times daily for 10 days by his dentist with no improvement. On presentation to the hospital oral surgery clinic, the patient's medical and dental histories were obtained an...

Efficacy of the addition of salicylic acid to clindamycin and benzoyl peroxide combination for acne vulgaris

AbstractClindamycin phosphate (CDP), benzoyl peroxide (BPO) and salicylic acid (SA) are known to be effective acne therapy agents depending on their anti‚?źinflammatory and comedolytic properties. The purpose of this study was to investigate the efficacy and tolerability of the addition of SA treatment to CDP and BPO (SA and CDP‚??+‚??BPO) and compare it with CDP‚??+‚??BPO in patients with mild to moderate facial acne vulgaris. Forty‚?źnine patients were enrolled in a 12‚??week prospective, single‚?źblind, randomized, comparative clinical study. Efficacy was assessed by lesion counts, global improvement, quality of life index and measurements of skin barrier functions. Local side effects were also evaluated. Both combinations were effective in reducing total lesion (TL), inflammatory lesio...

A high prevalence of mupirocin and macrolide resistance determinant among Staphylococcus aureus strains isolated from burnt patients

Abstract: Infections due to Staphylococcus aureus have become increasingly common among burn patients. The antibiotic resistance profile of S. aureus isolates and inducible resistance against clindamycin were investigated in this study. The presence of mecA gene, mupA gene and macrolide resistance genes were detected using PCR and multiplex-PCR. The resistance rate to methicillin, erythromycin and mupirocin were 58.5%, 58% and 40%, respectively. The prevalence of constitutive and inducible resistance among macrolide resistant isolates was 75% and 25%, respectively. Ninety five percent of the isolates were positive for one or more erm genes. The most common genes were ermA (75%), ermC (72%) and ermB (69%), respectively. The ermA gene predominated in the strains with the inducible phenotype,...<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>

Efficacy of the addition of salicylic acid to clindamycin and benzoyl peroxide combination for acne vulgaris

AbstractClindamycin phosphate (CDP), benzoyl peroxide (BPO) and salicylic acid (SA) are known to be effective acne therapy agents depending on their anti‚?źinflammatory and comedolytic properties. The purpose of this study was to investigate the efficacy and tolerability of the addition of SA treatment to CDP and BPO (SA and CDP‚??+‚??BPO) and compare it with CDP‚??+‚??BPO in patients with mild to moderate facial acne vulgaris. Forty‚?źnine patients were enrolled in a 12‚??week prospective, single‚?źblind, randomized, comparative clinical study. Efficacy was assessed by lesion counts, global improvement, quality of life index and measurements of skin barrier functions. Local side effects were also evaluated. Both combinations were effective in reducing total lesion (TL), inflammatory lesio...

[Streptococcal toxic shock syndrome or Kawasaki disease? Two case studies of children with group A streptococcal pneumonia empyema.]

We report 2 cases of children with group A streptococcus pyogenes pleuropneumonia, in one child associated with Kawasaki disease and in the other with streptococcal toxic shock syndrome. These 2 features, with theoretically well-defined clinical and biological criteria, are difficult to differentiate in clinical practice, however, likely due to their pathophysiological links. In case of clinical doubt, an echocardiography needs to be performed to search for coronary involvement and treatment including intravenous immunoglobulins, and an antibiotic with an anti-toxin effect such as clindamycin has to be started early. PMID: 22041597 [PubMed - as supplied by publisher] (Source: Archives de Pediatrie)

Higher incidence of perineal community acquired MRSA infections among toddlers

Conclusions: CAMRSA SSTI of the perineum was significantly more common among toddlers and that of the extremities in older children. The infecting strains were all USA300 PFT. Further studies are needed to identify the unique virulence and colonization characteristics of USA300 strains in these infections. (Source: BMC Pediatrics - Latest articles)

The efficacy of silver dressings and antibiotics on MRSA and MSSA isolated from burn patients

This study showed that the effect of pH and bacterial phenotypic state must be considered when the antimicrobial activity of silver wound dressings is being investigated. It is evident from the data generated that both pH and the bacterial phenotypic state are factors that induce changes that affect both antimicrobial performance and bacterial susceptibility. (Source: Wound Repair and Regeneration)

Clinical characteristics of infections caused by Tsukamurella spp. and antimicrobial susceptibilities of the isolates

In conclusion, strains of Tsukamurella spp., including T. spumae, are uncommon causative agents of ocular infections and bacteraemia in cancer patients. Molecular diagnostic methods are essential to distinguish species in the Tsukamurella genus from species in other phylogenetically related genera such as Rhodococcus. (Source: International Journal of Antimicrobial Agents)<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>

Clindamycin vs. first‚?źgeneration cephalosporins for acute osteoarticular infections of childhood‚??a prospective quasi‚?źrandomized controlled trial

Clin Microbiol InfectAbstractNo sufficiently powered trial has examined two antimicrobials in acute osteoarticular infections of childhood. We conducted a prospective, multicentre, quasi‚?źrandomized trial in Finland, comparing clindamycin with first‚?źgeneration cephalosporins. The age of patients ranged between 3¬†months and 15¬†years, and all cases were culture‚?źpositive. We assigned antibiotic treatment intravenously for the first 2‚??4¬†days, and continued oral treatment with clindamycin 40‚??mg/kg/24‚??h or first‚?źgeneration cephalosporin 150‚??mg/kg/24‚??h in four doses. Surgery was kept to a minimum. Subsiding symptoms and signs and normalization of C‚?źreactive protein (CRP) level were preconditions for the discontinuation of antimicrobials. The main outcome was full recovery wi...

Efficacy of combined topical treatment of acne vulgaris with adapalene and nadifloxacin: A randomized study

This study showed the efficacy and safety of the combination therapy of nadifloxacin cream with adapalene gel for the inflammatory acne. (Source: The Journal of Dermatology)

[Frequency and antibiotic resistance of Ureaplasma urealyticum and Mycoplasma hominis in genital samples of sexually active individuals].

CONCLUSIONS: Because none of the strains was sensitive to all examined antibiotics, the antibiotic sensitivity of U. urealyticum and M. hominis strains should be determined. The high rate of ofloxacin, erythromycin and clindamycin resistance should be considered in the therapy of U. urealyticum infections in Hungary. This is the first such a clinical microbiological study in this topic in Hungary. PMID: 21979223 [PubMed - in process] (Source: Orvosi Hetilap)

CLINDAMYCIN HYDROCHLORIDEcapsule, Gelatin Coated [Corepharma LLC.]

Updated Date: Oct 13, 2011 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

Prescription of antibiotics for adults hospitalized with community‚?źacquired pneumonia in Korea in 2004: A population‚?źbased descriptive study

Conclusions:‚?? In this study, patterns of antimicrobial prescription for patients hospitalized with CAP were assessed for the first time in Korea. There was divergence from the 2009 Korean guidelines for the treatment of CAP, reinforcing the need for assessment of physicians‚?? adherence to the guidelines. (Source: Respirology)<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>

Antimicrobial susceptibilities of Francisella tularensis subsp. holarctica strains isolated from humans in the Central Anatolia region of Turkey

Conclusions All strains were susceptible to the antibiotics traditionally used to treat tularaemia, such as streptomycin (MIC90 1.5 mg/L), gentamicin (MIC90 0.25 mg/L), tetracycline (MIC90 0.38 mg/L) and chloramphenicol (MIC90 0.25 mg/L). Since fluoroquinolones showed the lowest MIC values, and have important advantages over aminoglycosides, including ease of oral administration and lower toxicities, quinolones have the potential for being effective first-line therapy for tularaemia. (Source: Journal of Antimicrobial Chemotherapy)

Kounis Syndrome together with Myocardial Bridging Leading to Acute Myocardial Infarction at Young Age

In this report, we present the combination of Kounis syndrome and myocardial bridging leading to myocardial infarction at young age. (Source: Clinical and Developmental Immunology)

The outpatient institutional antibiogram does not accurately reflect the susceptibility of prepartum group B streptococcal isolates to erythromycin and clindamycin

This study compared the antimicrobial susceptibilities of 100 nonduplicate group B streptococcal (GBS) isolates from screening cultures of women attending OB-GYN clinics to a similar number of outpatient infection isolates recorded on the institutional antibiogram of a university teaching hospital. The screening GBS isolates were significantly more susceptible to erythromycin (72% versus 45%) and clindamycin (77% versus 48%) than the infection isolates. (Source: Diagnostic Microbiology and Infectious Disease)

The treatment of glue ear using biodegradable polymers to deliver high dose antibiotics and mucolytics to infection site

Aims: Recent evidence that otitis media with effusion (OME) is the result of a biofilm infection may explain the high rate of recurrence after conventional treatment with grommets. We aimed to test the in-vitro efficacy of antibiotics (Clindamycin and Rifampicin) and mucolytics (N-acetylcystiene) in eradicating middle ear biofilms using a biodegradable polymer that can be delivered locally. (Source: International Journal of Surgery)

CLINDAMYCIN HYDROCHLORIDEcapsule [Lannett Company, Inc.]

Updated Date: Oct 3, 2011 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>

FDA approves clindamycin injection

FDA has approved clindamycin injection, USP (Sagent Pharmaceuticals/Strides Arcolab), an antibiotic used to treat bacterial infections. (Source: Drug Topics - Top News)

Newer approaches in topical combination therapy for acne.

Authors: Fu LW, Vender RB Abstract Acne vulgaris is a common chronic inflammatory cutaneous disease involving the pilosebaceous unit. Its pathophysiology is multifactorial and complex, including obstruction of the pilosebaceous unit due to increased sebum production, abnormal keratinization, proliferation of Propionibacterium acnes (P. acnes), and inflammation. Topical agents are the most commonly used therapy for acne. First generation topicals mainly consist of single agent retinoids, benzoyl peroxide (BPO) and antibacterials that target comedones, P. acnes, and inflammation. Novel topical therapies include combination products with advanced vehicle formulations that target multiple acne pathophysiologies and offer simplified treatment regimes. For example, the combination of cli...<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>

Presence and characterization of Campylobacter jejuni in organically raised chickens in Quebec.

The objective of this study was to estimate the presence of the important foodborne pathogen Campylobacter jejuni in organically raised chickens in the province of Quebec. The recovered isolates were further characterized for their antimicrobial resistance profile, autoagglutination property and chemotaxis. Antimicrobial resistance was evaluated using agar dilution for: tetracycline, erythromycin, chloramphenicol, ciprofloxacin, gentamicin, nalidixic acid, clindamycin, ampicillin, azithromycin, bacitracin, and ceftiofur. Autoagglutination was measured by monitoring optical density changes in a bacterial suspension after 3 h of incubation at room temperature. Chemotaxis was evaluated after a contact time of 3 h between isolates and mucin, using a quantitative protocol. A total of 10 lots of...

Glycolic acid chemical peeling improves inflammatory acne eruptions through its inhibitory and bactericidal effects on Propionibacterium acnes

AbstractGlycolic acid chemical peeling is effective for treating comedones, and some clinical data show that it also improves inflammatory eruptions. The purpose of this study was to identify the mechanism of glycolic acid chemical peeling to improve inflammatory acne. To assess growth inhibitory and bactericidal effects of glycolic acid on Propionibacterium acnes in vitro, we used an agar diffusion method and a time‚?źkill method. To reveal bactericidal effects in vivo, we established an agar‚?źattached method which correlated well with the ordinary swab‚?źwash method, and we used the agar‚?źattached method to compare the numbers of propionibacteria on the cheek treated with glycolic acid chemical peeling. Our results show that 30% glycolic acid (at pH‚??1.5, 3.5 and 5.5) formed growth in...

Clindamycin/venlafaxine: Agranulocytosis in an elderly patient: case report

(Source: Reactions)

clindamycin - oral, Cleocin

Title: clindamycin - oral, CleocinCategory: MedicationsCreated: 3/2/2005Last Editorial Review: 9/21/2011 (Source: MedicineNet HIV General)<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>

Is the use of antibiotic-impregnated external ventricular drainage beneficial in the management of iatrogenic ventriculitis?

Conclusions&nbsp;&nbsp;This retrospective pilot study indicates that B-EVD might have no major advantage in the management of EVD or VP-shunt-related ventriculitis. Based on published reports and the results of this study, data support only the prophylactic use of B-EVD for prevention of EVD-related infections. Prospective randomized clinical trials are warranted to further evaluate the role of B-EVD in the treatment of ventriculitis. Content Type Journal ArticleCategory Clinical ArticlePages 1-4DOI 10.1007/s00701-011-1156-5Authors Jehuda Soleman, Department of Neurosurgery, Kantonsspital Aarau, Tellstrasse, 5001 Aarau, SwitzerlandSerge Marbacher, Department of Neurosurgery, Kantonsspital Aarau, Tellstrasse, 5001 Aarau, SwitzerlandJavier Fandino, Department of Neurosurgery, K...

Antibiotics for ureaplasma in the vagina in pregnancy.

CONCLUSIONS: There is insufficient evidence to assess whether pregnant women who have vaginal colonisation with ureaplasma should be treated with antibiotics to prevent preterm birth.Preterm birth is a significant perinatal problem. Upper genital tract infections, including ureaplasmas, are suspected of playing a role in preterm birth and preterm rupture of the membranes. Antibiotics are used to treat women with preterm prelabour rupture of the membranes; this may result in prolongation of pregnancy and lowers the risks of maternal and neonatal infection. However, antibiotics may be beneficial earlier in pregnancy to eradicate potentially causative agents. PMID: 21901685 [PubMed - in process] (Source: Cochrane Database of Systematic Reviews)

Value of patch tests in clindamycin‚?źrelated drug eruptions

Discussion. We considered the positive patch tests results with clindamycin, in the 9 patients with maculopapular exantema, to be specific, versus the negative results observed in the control group. Although the sensitivity is low (30%), they confirmed the responsibility of this antibiotic in cutaneous adverse drug reactions in which, with only chronological criteria, it was not possible to conclude on the culprit drug. (Source: Contact Dermatitis)

Prevalence of Corynebacterium ulcerans in dogs residing in Osaka, Japan.

Authors: Katsukawa C, Komiya T, Yamagishi H, Ishii A, Nishino S, Nagahama S, Iwaki M, Yamamoto A, Takahashi M Abstract Diphtheria-like human illness caused by Corynebacterium ulcerans is an emerging threat in developed countries, with incidence sometimes higher than that of diphtheria caused by Corynebacterium diphtheriae. Companion animals are considered a potential source of human infections. In order to determine the prevalence of C. ulcerans among dogs, we performed a screening for the bacterium in 583 dogs in the custody of the Osaka Prefectural government. Forty-four dogs (7.5%) were positive for the bacterium, although they did not show any clinical symptoms. All bacterial isolates showed resistance or decreased sensitivity to clindamycin, and some, decreased sensitivity to ...

CLINDAMYCIN (Clindamycin Phosphate) Injection [Bedford Laboratories]

Updated Date: Sep 14, 2011 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>

Multidrug resistance in European Clostridium difficile clinical isolates

Conclusions Characterization of multidrug-resistant C. difficile clinical isolates shows that antibiotic resistance is changing, involving new determinants and mechanisms and providing this pathogen with potential advantages over the co-resident gut flora. The present paper provides, for the first time, a comprehensive picture of the different characteristics of multidrug-resistant C. difficile strains in Europe in 2005 and represents an important source of data for future comparative European studies. (Source: Journal of Antimicrobial Chemotherapy)

Serotypes and Antibiotic Resistance in Group B Streptococcus Isolated from Patients at the Maternity Hospital, Kuwait.

Authors: Boswihi SS, Udo EE, Al-Sweih N Abstract A total of 143 GBS isolates collected from mothers at the Maternity hospital in Kuwait were investigated for their serotypes and antibiotic resistance, and screened for the carriage of genes for tetracycline (tetk, tetM, tetL, tetO), erythromycin ( ermA, ermB, ermC, ermTR, ermM, mefA, mefE, msrA) and aminoglycosides (aph3, ant4, ant6) resistance by PCR. All isolates were serotyped using latex agglutination test. Most of the isolates belonged to serotypes V (38.5%), III (20.9%), Ia (7.7%), and II (11.2%). Sixteen isolates (11.2%) were nontypeable. All isolates were susceptible to penicillin, ampicillin and cefotaxime (MIC: 0.016- 0.094 microgram ml-1) but were resistant to trimethoprim (92.3%), tetracycline (89.5%), minocycline (89.5%...

Identification and characterization of plasmid-borne erm(T) macrolide resistance in group B and group A Streptococcus

Abstract: One hundred and seven group B Streptococcus (GBS) isolates and 344 group A Streptococcus (GAS) isolates were collected between 2005 and 2009 from 2 area hospitals and studied for resistance to erythromycin (ERY) and clindamycin (CLI) and the presence of the erm(T) macrolide resistance gene. The erm(T) gene was found in 5 (8%) of 61 erythromycin nonsusceptible GBS isolates and in 22 (55%) of 40 erythromycin nonsusceptible GAS isolates. The erm(T) gene in all 27 GBS/GAS erm(T) gene‚??positive isolates was located on a plasmid. Three erm(T) gene‚??positive plasmids were DNA sequenced. Two plasmids (1 each from GBS and GAS isolates) were both 4967 bp in size, contained the erm(T) gene, and differed by only 2 base pairs, suggesting interspecies horizontal transfer of the erm(T) gene c...

CLINDAMYCIN HYDROCHLORIDEcapsule [Aurobindo Pharma Limited]

Updated Date: Sep 6, 2011 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

Clinical and microbiological features of bacteraemia with Aerococcus urinae

Clin Microbiol InfectAbstractAerococcus urinae is a Gram‚?źpositive bacterium that can cause invasive infection, including infectious endocarditis (IE), mainly in older men. A.¬†urinae is often misclassified in routine diagnostic laboratories. Through searches in the laboratory databases we identify 16 isolates of A.¬†urinae causing bacteraemia during a 6‚?źyear period in southern Sweden, indicating that bacteraemia with A.¬†urinae occurs in at least three cases per million inhabitants per year. The identity of isolates was confirmed by sequencing of the 16S rRNA genes and antibiotic susceptibility testing identified two ciprofloxacin‚?źresistant isolates. A.¬†urinae was the only significant pathogen isolated in all cases. Fifteen of the 16 patients were male, 15/16 were more than 70‚??yea...<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>

Cochrane Review: Minocycline for acne vulgaris: efficacy and safety

AbstractBackgroundMinocycline is a tetracycline antibiotic that is commonly used in the treatment of moderate to severe acne vulgaris. Although it is more convenient for patients to take than first‚?źgeneration tetracyclines, as it only needs to be taken once or twice a day and can be taken with food, it is more expensive. Concerns have also been expressed over its safety following the deaths of two patients taking the drug. There is a lack of consensus among dermatologists over the relative risks and benefits of minocycline. As most acne prescribing is undertaken by general practitioners, it is important that guidelines issued to them are based on the best available evidence rather than personal judgements.ObjectivesTo collate and evaluate the evidence on the clinical efficacy of minocycl...

Combination Therapy Can't Beat Bacterial Vaginosis

QUEBEC CITY ‚?? Oral metronidazole was not more effective for bacterial vaginosis when combined with clindamycin or a probiotic, based on data from 450 women. ‚??Bacterial vaginosis is the most common cause of infections in women worldwide,‚?Ě said Dr. Catriona Bradshaw of the University of Melbourne. Current monotherapy treatments are not highly effective, and up to 50%-60% of women have recurrent bacterial vaginosis (BV) after treatment. Dr. Bradshaw and her colleagues examined whether a combination of oral and vaginal therapy could be more effective. (Source: Ob.Gyn. News)

Nasal carriage of methicillin resistant Staphylococcus aureus and their antibiotic susceptibility patterns in children attending day-care centers.

In this study we investigated the frequency of MRSA colonization and their antibiotic susceptibility patterns in 1-6 years old children of day-care centers in Hamadan, West of Iran.Five hundred nasal swabs were collected from children of 27 day-care centers that had no risk factors for colonization by S. aureus. The specimens were cultured for isolation of S. aureus by standard methods. Antimicrobial susceptibility testing was performed according to the Clinical and Laboratory Standards Institute (CLSI) guidelines. For evaluation of the frequency of erythromycin induced clindamycin resistance, disk approximation test (D-test) was applied.Totally, 148 (29.6%) children were colonized by S. aureus. Out of 260 male, 94 (36.2%) and of 240 female, 54 (22.5%) cases were nasal carriers of S. aureu...

Comparative Effectiveness of Antibiotic Treatment Strategies for Pediatric Skin and Soft-Tissue Infections

CONCLUSIONS:Compared with clindamycin, use of trimethoprim-sulfamethoxazole or &beta;-lactams was associated with increased risks of treatment failure and recurrence. Associations were stronger for those with a drainage procedure. (Source: PEDIATRICS)

Characterization of highly antimicrobial-resistant clinical pneumococcal isolates recovered in a Chinese hospital during 2009-2010.

Authors: Zhang B, Gertz RE, Liu Z, Li Z, Fu W, Beall B Abstract Ninety-one consecutive pneumococcal isolates (primarily from sputum), recovered in Chongqing Southwest Hospital during a 12 month period in 2009-2010 from individuals of all ages with suspected cases of pneumococcal disease, were subjected to PCR-serotyping, quellung reaction serotyping, antimicrobial susceptibility testing, and multilocus sequence typing (MLST). Although 20 different serotypes were observed, most isolates (69 = 75.8%) were of serotypes included in the pneumococcal 13-valent conjugate vaccine (PCV13), including 33 of the 46 (71.7%) isolates recovered from individuals less than 5 years of age. The prevalent serotypes were 19F (34%), 19A (9.9%), 6B (9.9%), 23F (7.7%), 14 (6.6%), and 6A (4.4%). PCR-determ...

Clonality behind the increase of multidrug-resistance among non-invasive pneumococci in Southern Finland

Abstract&nbsp;&nbsp;Multidrug-resistance among Streptococcus pneumoniae isolates, especially of serotype 19A, has increased in several countries recently. Even before the introduction of the pneumococcal conjugate vaccine into the Finnish National Vaccination Programme, the proportion of multidrug-resistant (MDR) pneumococci had doubled from 2007 to 2008, when it reached 3.6% in Southern Finland. Our aim was to look for a possible association between antimicrobial susceptibility and clonality among the MDR isolates. Twelve non-invasive isolates non-susceptible to penicillin, erythromycin, clindamycin, trimethoprim/sulfamethoxazole, and doxycycline from 2008 were available for serotyping, genotyping by multilocus sequence typing (MLST), and detection of genes encoding macrolide resista...

CLINDAMYCIN HYDROCHLORIDEcapsule [UDL Laboratories, Inc.]

Updated Date: Aug 25, 2011 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

Molecular epidemiology of meticillin-resistant Staphylococcus aureus in Italian cystic fibrosis patients: A national overview

Conclusions: Known MRSA epidemic clones such as USA600, USA800, USA1100, and UK EMRSA-3 were described for the first time in Italy. The diffusion of MRSA strains with high pathogenic potential in the CF population suggests that analysis of the MRSA strains involved in pulmonary infections of these patients is needed. (Source: Journal of Cystic Fibrosis)

Antibiotic resistance pattern among the Salmonella isolated from human, animal and meat in India

Abstract&nbsp;&nbsp;The present study was conducted to study the antibiotic resistance pattern among nontyphoidal Salmonella isolated from human, animal and meat. A total of 37 Salmonella strains isolated from clinical cases (human and animal) and meat during 2008‚??2009 belonging to 12 serovars were screened for their antimicrobial resistance pattern using 25 antimicrobial agents falling under 12 different antibiotic classes. All the Salmonella isolates tested showed multiple drug resistance varying from 5.40% to 100% with 16 of the 25 antibiotics tested. None of the isolates were sensitive to erythromycin and metronidazole. Resistance was also observed against clindamycin (94.59%), ampicillin (86.49%), co-trimoxazole (48.65%), colistin (45.94%), nalidixic acid (35.10%), amoxyclave (1...<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>

Extended antimicrobial treatment of bacterial vaginosis combined with human lactobacilli to find the best treatment and minimize the risk of relapses

Conclusions: The study shows that aggressive treatment of the patient with antibiotics combined with specific Lactobacillus strain administration and partner treatment can provide long lasting cure. A striking result of our study is that change of partner is strongly associated with relapse of BV.Trial registration: NCT01245322 (Source: BMC Infectious Diseases)

Wrong antibiotic used for resistant skin infections

For many pediatricians, trimethoprim-sulfamethoxazole (TMP-SMX) may be the oral antibiotic of choice when a patient presents with a community-associated methicillin-resistant Staphylococcus aureus skin infection, but another drug?clindamycin?may actually work better, according to a new study. Find out why the experts recommend clindamycin, even though there seemed to be good reasons to prescribe TMP-SMX. (Source: Modern Medicine)

Increasing antibiotic resistance in Streptococcus pneumoniae colonizing children attending day care centres in Singapore

Conclusions:‚??S. pneumoniae antibiotic resistance has risen dramatically over the last 10 years in Singapore. Wider conjugate vaccine uptake and improved antibiotic stewardship should be made priorities. Surveillance of sentinel sites like day care centres provides important data with respect to shifts in pneumococcal ecology. (Source: Respirology)

Clindamycin Works Better for Skin Infections in Kids (CME/CE)

(MedPage Today) -- For children with skin and soft tissue infections, clindamycin is the antibiotic of choice for empiric treatment, researchers found. (Source: MedPage Today Pediatrics)<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>

Antibiotics, Acne, and Staphylococcus aureus Colonization [Study]

Conclusion&nbsp; Unlike current dogma about the long-term use of antimicrobial agents, the prolonged use of tetracycline antibiotics commonly used to treat acne lowered the prevalence of colonization by S aureus and did not increase resistance to the tetracycline antibiotics. (Source: Archives of Dermatology)

Trimethoprim-sulfamethoxazole mightn't help soft tissue infection in kids

NEW YORK (Reuters Health) - In regions with prevalent community-acquired MRSA (methicillin-resistant Staphylococcus aureus), pediatric skin and soft-tissue infections will likely respond better to clindamycin than to trimethoprim-sulfamethoxazole (TMP-SMX) or beta-lactams, a new study suggests. (Source: Modern Medicine)

Seventy-nine-year-old man with Langerhans cell histiocytosis treated with cladribine

To the Editor: A 79-year-old white man presented with a 6-year history of a pruritic rash that had progressed to skin breakdown in the body fold areas. Prior therapy included itraconazole, ketoconazole, trimethoprim-sulfamethoxazole, clindamycin, minocycline, doxycycline, penicillin VK, mupirocin, nystatin cream, and clobetasol lotion without resolution. (Source: Journal of the American Academy of Dermatology)

PCR ribotype prevalence and molecular basis of macrolide-lincosamide-streptogramin B (MLSB) and fluoroquinolone resistance in Irish clinical Clostridium difficile isolates

Conclusions Resistance to MLSB and fluoroquinolone antimicrobial compounds is common among prevalent ribotypes of C. difficile. The genetic basis for antimicrobial resistance appears to be ribotype specific and conserved in the absence of recent antimicrobial selection pressure. (Source: Journal of Antimicrobial Chemotherapy)

Single and dual mutations at positions 2058, 2503 and 2504 of 23S rRNA and their relationship to resistance to antibiotics that target the large ribosomal subunit

Conclusions 23S rRNA mutations A2058G, A2503U and U2504G play key roles in resistance to clinically useful antibiotics that target the large ribosomal subunit. Furthermore, the double mutations A2058G&ndash;A2503U and A2058G&ndash;U2504G have combined effects on resistance to 16-membered macrolides. (Source: Journal of Antimicrobial Chemotherapy)<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>

Impact of guidelines and enhanced antibiotic stewardship on reducing broad-spectrum antibiotic usage and its effect on incidence of Clostridium difficile infection

Conclusions Revised antibiotic guidelines and enhanced stewardship was associated with a significant stepwise reduction in the use of cephalosporins and fluoroquinolones and a significant decrease in the incidence of CDI. (Source: Journal of Antimicrobial Chemotherapy)

Meta-analysis of randomized controlled trials using 5% benzoyl peroxide and clindamycin versus 2.5% benzoyl peroxide and clindamycin topical treatments in acne

To the Editor: Combination benzoyl peroxide (BPO) and clindamycin (CL) products play an important role in topical antimicrobial acne treatment. These agents are combined to improve efficacy over either single agent alone and to decrease antimicrobial resistance. On the market, combination products include 5% BPO and 1% CL and 2.5% BPO and 1.2% CL. Our recent meta-analysis of topical BPO and CL products analyzed efficacy of all combination BPO/CL products together, which prompted us to conduct this additional analysis to further compare efficacy between 5% BPO/CL and 2.5% BPO/CL combination products. (Source: Journal of the American Academy of Dermatology)

Clindamycin vs. first‚?źgeneration cephalosporins for acute osteoarticular infections of childhood‚??a prospective quasi‚?źrandomized controlled trial

Clin Microbiol InfectAbstractNo sufficiently powered trial has examined two antimicrobials in acute osteoarticular infections of childhood. We conducted a prospective, multicentre, quasi‚?źrandomized trial in Finland, comparing clindamycin with first‚?źgeneration cephalosporins. The age of patients ranged between 3¬†months and 15¬†years, and all cases were culture‚?źpositive. We assigned antibiotic treatment intravenously for the first 2‚??4¬†days, and continued oral treatment with clindamycin 40‚??mg/kg/24‚??h or first‚?źgeneration cephalosporin 150‚??mg/kg/24‚??h in four doses. Surgery was kept to a minimum. Subsiding symptoms and signs and normalization of C‚?źreactive protein (CRP) level were preconditions for the discontinuation of antimicrobials. The main outcome was full recovery wi...

What Would We Do Without Metronidazole?

Authors: Stover KR, Riche DM, Gandy CL, Henderson H Metronidazole is a treatment of choice for several types of infections, but coexisting conditions or concomitant medications may preclude its use. Although tinidazole, a newer nitroimidazole, may be an option in cases where drug interactions make the use of metronidazole inadvisable, similar absolute contraindications exist. In situations where nitroimidazole use is contraindicated or inadvisable, clinicians may have difficulty deciding on efficacious treatment options. For the treatment of trichomoniasis, alternatives include furazolidone, clotrimazole, nonoxynol-9 or paromomycin. Alternativesfor bacterial vaginosis include clindamycin topically or systemically. For giardiasis, alternative options include paromomycin, nitazoxanide or...

Is Methicillin-Resistant Staphylococcus aureus Pneumonia Epidemiology and Sensitivity Changing?

CONCLUSIONS:: Resistance to clindamycin has increased over time, but TMP/SMX has preserved its sensitivity against MRSA. TMP/SMX should be revisited as a viable antibiotic option against CA-MRSA and HA-MRSA, specifically against CA-MRSA. PMID: 21817882 [PubMed - as supplied by publisher] (Source: The American Journal of the Medical Sciences)<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>

For preventing perinatal group B Strep, vancomycin a last resort

NEW YORK (Reuters Health) - Penicillin remains the agent of choice for preventing perinatal transmission of group B streptococcus (GBS). When the mother is at high risk for penicillin anaphylaxis, the next choice is clindamycin, as long as the GBS isolate is susceptible. If not, use vancomycin (Source: Modern Medicine)

Clindamycin vs first‚?źgeneration cephalosporins for acute osteoarticular infections of childhood ‚?? prospective quasi‚?źrandomized controlled trial

AbstractNo sufficiently‚?źpowered trial has examined two antimicrobials in acute osteoarticular infections of childhood. We conducted a prospective multicenter, quasi‚?źrandomized trial in Finland comparing clindamycin with first‚?źgeneration cephalosporins. The age ranged between 3 months and 15 years, and all cases were culture‚?źpositive. We assigned antibiotic treatment intravenously for first 2‚?ź4 days and continued oral treatment with clindamycin 40 mg/kg/24h q.i.d. or first‚?źgeneration cephalosporin 150 mg/kg/ 24h q.i.d. Surgery was kept at minimum. Subsiding symptoms and signs and normalization of C‚?źreactive protein level (CRP) was a precondition for the discontinuation of antimicrobials. The main outcome was full recovery without further antimicrobials because of an osteoartic...

Significant decline in the erythromycin resistance of group A streptococcus isolates at a German paediatric tertiary care centre

Abstract&nbsp;&nbsp;Group A streptococcus (GAS) is considered to be a major pathogen of bacterial tonsillopharyngitis in children. Although GAS is generally susceptible to penicillin, macrolides are often used as the second-line treatment. Over the last several decades, the rising macrolide resistance of GAS has been detected in several countries. With the current study, we aimed to determine the development of macrolide resistance at our paediatric centre. From March 2006 to May 2009, 350 GAS isolates were tested for susceptibility to erythromycin, azithromycin, clindamycin, penicillin and cefotaxime. Macrolide-resistant isolates were screened for the presence of genes related to macrolide resistance (mefA, ermB, ermTR, prtF1). In comparison to a prior study at our hospital, the eryt...

CLINDAMYCIN (Clindamycin Phosphate) Injection, Solution, Concentrate [Hospira, Inc.]

Updated Date: Jul 26, 2011 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

CLINDAMYCIN HYDROCHLORIDEcapsule [Bryant Ranch Prepack]

Updated Date: Jul 26, 2011 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>

Individualized antibiotic prophylaxis reduces surgical site infections by gram-negative bacteria in instrumented spinal surgery

Conclusion&nbsp;&nbsp; Higher preoperative GNB colonization rates were found in patients with neurogenic bladder or indwelling catheters. Preoperative bacteriological screening, treatment for bacteriuria, and individualized antibiotic prophylaxis were effective for reducing GNB SSI. Content Type Journal ArticlePages 1-6DOI 10.1007/s00586-011-1906-3Authors Susana N√ļ√Īez-Pereira, German Scoliosis Center Bad Wildungen, Im Kreuzfeld 4, 34537 Bad Wildungen, GermanyF. Pellis√©, Spine Unit, Hospital Vall d‚??Hebron, Passeig Vall d‚??Hebron 119-129, 08035 Barcelona, SpainD. Rodr√≠guez-Pardo, Infectious Diseases Department, Hospital Vall d‚??Hebron, Passeig Vall d‚??Hebron 119-129, 08035 Barcelona, SpainC. Pigrau, Infectious Diseases Department, Hospital Vall d‚??Hebron, Passeig Vall ...

In vitro activity of ceftobiprole and seven other antimicrobial agents against invasive Streptococcus pneumoniae isolates in Spain

Abstract&nbsp;&nbsp;The in vitro activity of ceftobiprole was compared with that of seven antimicrobial agents against invasive Streptococcus pneumoniae isolated from adult patients (&gt;15&nbsp;years old). Characterization of erythromycin-resistant strains and serotype distribution of all pneumococci were also evaluated. Seventy invasive S. pneumoniae strains were isolated from December 2007 to January 2009. Serotyping was carried out by Quellung reaction. Antibiotic susceptibility was tested by broth microdilution (CLSI guidelines). The comparator agents were penicillin, cefotaxime, erythromycin, clindamycin, telithromycin, tetracycline and moxifloxacin. Phenotypic characterization of macrolide resistance was performed by the double disk method. Macrolide resistance genes [erm(B) and...

Cervical necrotising fasciitis with descending necrotising mediastinitis

Case report A previously healthy 77-year-old man presented with difficulty in swallowing saliva following a 4-day history of sore throat. He was dysphonic with an indurated cellulitic fullness in the left lateral aspect of his neck. Nasendoscopy demonstrated ipsilateral pharyngeal wall swelling and contralateral laryngeal deviation. Contrast-enhanced CT examination demonstrated gas and fluid in the pretracheal and left perivascular deep neck spaces (figure 1A), in keeping with infection caused by gas-forming organisms. The gas and fluid tracked into the superior and anterior mediastinum with an associated mediastinal collection (figure 1B). Transcervical drainage confirmed malodorous dishwater-type fluid and grey necrotic tissue consistent with necrotising fasciitis that extended into the ...

The Emergence of Clostridium difficile Infection among Peripartum Women: A Case-Control Study of a C. difficile Outbreak on an Obstetrical Service

Conclusions. The outbreak was reduced after the implementation of multiple infection control measures and modification of antibiotic use. However, sporadic CDI continued for 8 months after these measures slowed the outbreak. Peripartum women appear to be another population susceptible to CDI. (Source: Clinical and Developmental Immunology)

Analysis of the Antimicrobial Susceptibility of Anaerobic Bacteria Isolated from Endodontic Infections in Brazil during a Period of Nine Years

Conclusions: The antimicrobial resistance of anaerobes isolated from primary endodontic infections showed an increase throughout a period of time regarding a specific Brazilian population. (Source: Journal of Endodontics)<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>

In Vitro Elution and Antibacterial Activity of Clindamycin, Amikacin, and Vancomycin from R‚?źgel Polymer

Conclusions: Amikacin and clindamycin together, or in combination with vancomycin, elute from R‚?źgel‚?Ę effectively and at gradually decreasing concentrations for at least 10 days. The antibiotics maintained their bioactivity following polymerization and elution from the R‚?źgel‚?Ę. (Source: Veterinary Surgery)

In vitro pharmacokinetic/pharmacodynamic activity of NXL103 versus clindamycin and linezolid against clinical Staphylococcus aureus and Streptococcus pyogenes isolates

The objective of this study was to evaluate the in vitro activity of NXL103 in comparison with oral comparators (clindamycin and linezolid). Six clinical isolates [four meticillin-resistant Staphylococcus aureus (MRSA) and two Streptococcus pyogenes] were exposed for 48h in an in vitro pharmacokinetic/pharmacodynamic (PK/PD) model at a starting inoculum of ca. 106 colony-forming units (CFU)/mL. Antimicrobial simulations included NXL103 500mg every 12h, linezolid 600mg every 12h and clindamycin 450mg every 6h. Bactericidal and static effects were defined as ‚?•3log10 and (Source: International Journal of Antimicrobial Agents)

An outbreak of a Multiresistant Methicillin-Susceptible Staphylococcus aureus (MR-MSSA) strain in a Burn Centre: The importance of routine molecular typing

Abstract: Here we report an outbreak among 17 patients caused by a single strain of a Multiresistant Methicillin-Susceptible Staphylococcus aureus (MR-MSSA) in a burn centre. The MR-MSSA strains were resistant to penicillin, ciprofloxacin, erythromycin, clindamycin and co-trimoxazole. Further analysis showed an increased prevalence of MR-MSSA carriership in S. aureus colonized patients admitted to the burn centre, from 0% in 2005 (0/118), 3.3% in 2006 (4/121), 6.1% in 2007 (6/99), to 7.8% in 2008 (7/90). Molecular typing with Amplified Fragment Length Polymorphism showed that all MR-MSSA isolates derived from burn centre patients had a unique genotype, and was different compared to isolates derived from other hospital patients. All healthcare workers (HCWs) who worked in the burn centre du...

Bacillus cereus from blood cultures: virulence genes, antimicrobial susceptibility and risk factors for blood stream infection

AbstractWe characterized the profiles of virulence genes and antimicrobial susceptibility of Bacillus cereus isolates from blood cultures, as well as the risk factors for blood stream infections (BSIs). The diversity of virulence gene patterns was found to be wide among 15 B. cereus isolates from BSIs and also among 11 isolates from contaminated blood cultures. The MicroScan broth microdilution method yielded results corresponding with those of the agar dilution (reference) method for levofloxacin, linezolid and vancomycin, while the Etest results were consistent with the reference results for clindamycin, gentamicin, imipenem, levofloxacin and linezolid. Compared with the reference values, however, some isolates showed marked differences of the minimum inhibitory concentrations (MICs) for...

Incidence of and Risk Factors for Community-associated Clostridium difficile Infection: a nested case-control study

Conclusions: Our study documented that the epidemiology of CDI is changing, with CA-CDI occurring in populations not traditionally considered "high-risk" for the disease. Clinicians should consider this diagnosis and obtain appropriate diagnostic testing for outpatients with persistent or severe diarrhea who have even remote antimicrobial exposure. (Source: BMC Infectious Diseases)<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>

Endodontic Pathogens Causing Deep Neck Space Infections: Clinical Impact of Different Sampling Techniques and Antibiotic Susceptibility

Conclusions: The results of our study indicated that a greater number of anaerobes were found when sampling using the aspiration technique. Penicillin G and aminopenicillins alone are not always sufficient for the treatment of severe deep neck space abscesses; beta-lactamase inhibitor combinations are more effective. Bacteria showed significant resistant rates to clindamycin. Thus, its single use in penicillin-allergic patients has to be carefully considered. (Source: Journal of Endodontics)

EVOCLIN (Clindamycin Phosphate) Aerosol, Foam [Stiefel Laboratories Inc]

Updated Date: Jul 14, 2011 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

CLINDAMYCIN HYDROCHLORIDEcapsule [REMEDYREPACK INC. ]

Updated Date: Jul 11, 2011 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

In Vitro Antibacterial Activity of NB-003 against Propionibacterium acnes.

Authors: Pannu J, McCarthy A, Martin A, Hamouda T, Ciotti S, Ma L, Sutcliffe J, Baker JR NB-003 and NB-003 gel formulations are oil-in-water nanoemulsions designed for use in bacterial infections. In vitro susceptibility of Propionibacterium acnes to NB-003 formulations and comparator drugs was evaluated. Both NB-003 formulations were bactericidal against all P. acnes isolates, including those that were erythromycin-, clindamycin- and/or tetracycline-resistant. In the absence of sebum the MIC(90)/MBC(90) values for NB-003, NB-003 gel, salicylic acid (SA), and benzoyl peroxide (BPO) were 0.5/2.0, 1.0/2.0, 1000/2000 and 50/200 őľg/ml respectively. In the presence of 50% sebum, the MIC(90)/MBC(90) of NB003 and BPOs increased to 128/1024 and 400/1600 őľg/ml respectively. The MIC(90)/MBC(90...

Pulmonary Infections and Community Associated Methicillin Resistant Staphylococcus Aureus: A Dangerous Mix?

Summary: The incidence of complicated pneumonias in children is increasing with a concurrent increase in the incidence of community-associated methicillin-resistant Staphylococcus aureus (CA-MRSA) infections. CA-MRSA is distinct from hospital associated MRSA [HA-MRSA] in regards to its genotype, epidemiology, and clinical course. Unlike HA-MRSA, CA-MRSA often strikes young, previously healthy children. Pneumonias caused by CA-MRSA have a rather distinct presentation. Because of its pore-forming toxins, namely Panton-Valentine leukocidin (PVL) and alpha-hemolysin, extensive necrotizing disease with corresponding hypoxaemia and hypercarbia is common. Other features include multilobar disease, leucopenia, haemoptysis, and high mortality rates. A previous influenza-like illness or skin and sof...<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>

A double-blind study of the efficacy and safety of multiple daily doses of amikacin versus one daily dose for children with perforated appendicitis in Costa Rica

Conclusions: In this patient population of Costa Rican children with perforated appendicitis, we found that amikacin ODD is as safe and effective as the MDD regimen. This could have implications for national health systems such as that in Costa Rica, as ODD is presumably a more economic option and may reduce the cost of antibiotic treatment in patients with perforated appendicitis. This would need to be confirmed through an economic analysis, which is outside the purview of this paper. (Source: International Journal of Infectious Diseases)

Randomised Double-Blind Trial of Combination Antibiotic Therapy in Rheumatoid Arthritis

Conclusion. This antibiotic regime is unlikely to be a valuable therapy for active rheumatoid arthritis. (Source: Advances in Pharmacological Sciences)

CLINDAMYCIN HYDROCHLORIDEcapsule [REMEDYREPACK INC. ]

Updated Date: Jul 5, 2011 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

CLEOCIN PHOSPHATE (Clindamycin Phosphate) Injection, Solution [Pharmacia And Upjohn Company]

Updated Date: Jun 30, 2011 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

CLINDAMYCIN (Clindamycin Phosphate) Injection, Solution, Concentrate [Cardinal Health]

Updated Date: Jun 30, 2011 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>

Folliculitis et perifolliculitis capitis abscedens et suffodiens controlled with a combination therapy: Systemic antibiosis (Metronidazole Plus Clindamycin), dermatosurgical approach, and high-dose isotretinoin

Georgi TchernevIndian Journal of Dermatology 2011 56(3):318-320Folliculitis et perifolliculitis capitis abscedens et suffodiens is a rare disease of unknown etiology. It is a suppurative process that involves the scalp, eventually resulting in extensive scarring and irreversible alopecia. The condition is also known as &#x0027;acne necrotica miliaris&#x0027; or &#x0027;Proprionibacterium&#x0027; folliculitis. Most often the disease affects men of African-American or African-Caribbean descent between 20 and 40 years of age. The clinical picture is determined by fluctuating painful fistule-forming conglomerates of abscesses in the region of the occipital scalp. The cause of scalp folliculitis is not well understood. It is generally considered to be an inflammatory reaction to components of t...

CLEOCIN HYDROCHLORIDE (Clindamycin Hydrochloride) Capsule [Pharmacia And Upjohn Company]

Updated Date: Jun 29, 2011 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

CLINDAMYCIN HYDROCHLORIDEcapsule [RedPharm Drug Inc.]

Updated Date: Jun 24, 2011 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

Clinical and microbiological features of bacteraemia with Aerococcus urinae

Clin Microbiol InfectAbstractAerococcus urinae is a Gram‚?źpositive bacterium that can cause invasive infection, including infectious endocarditis (IE), mainly in older men. A.¬†urinae is often misclassified in routine diagnostic laboratories. Through searches in the laboratory databases we identify 16 isolates of A.¬†urinae causing bacteraemia during a 6‚?źyear period in southern Sweden, indicating that bacteraemia with A.¬†urinae occurs in at least three cases per million inhabitants per year. The identity of isolates was confirmed by sequencing of the 16S rRNA genes and antibiotic susceptibility testing identified two ciprofloxacin‚?źresistant isolates. A.¬†urinae was the only significant pathogen isolated in all cases. Fifteen of the 16 patients were male, 15/16 were more than 70‚??yea...

Clinical and microbiological features of bacteremia with Aerococcus urinae

AbstractAerococcus urinae is a Gram‚?źpositive bacterium that can cause invasive infection, including infectious endocarditis (IE), mainly in older men. A. urinae is often misclassified in routine diagnostic laboratories. Through searches in the laboratory databases we identify sixteen isolates of A. urinae causing bacteremia during a six‚?źyear‚?źperiod in Southern Sweden, indicating that bacteremia with A. urinae occurs in at least 3 cases per million inhabitants per year. The identity of isolates was confirmed by sequencing of the 16S rRNA genes and antibiotic susceptibility testing identified two ciprofloxacin resistant isolates. A. urinae was the only significant pathogen isolated in all cases. Fifteen of the 16 patients were male, 15/16 were more than 70 years old, and 12/16 had unde...<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>

A study on erm(B)-mediated MLS resistance in Streptococcus pyogenes clinical isolates

Abstract: The constitutive or inducible macrolide‚??lincosamide‚??streptogramin (MLS) phenotype of 30 erm(B)-positive Streptococcus pyogenes isolates was determined by different methods and under various growth conditions and correlated to the sequence of the 5‚?≤-untranslated regions of erm(B). The MLS phenotype of one-third of the isolates could not be classified. In liquid medium, some of these isolates responded to induction only during the logarithmic phase of growth, while others expressed clindamycin resistance even under noninducing conditions. By increasing the growth rate, we observed a shift from a constitutive towards an inducible pattern of resistance. All data were confirmed by analysis of the 23S rRNA methylation level. The erm(B)-5‚?≤-untranslated region was 99% similar in ...

Transfusion-transmitted Babesiosis in an Immunocompromised Patient: A Case Report and Review

Abstract: Babesiosis is a tick- and transfusion-borne disease caused by intraerythrocytic Babesia parasites. In 2009, a 61-year-old Minnesota woman with chronic lymphocytic leukemia and a history of recent chemotherapy and numerous blood transfusions for gastrointestinal bleeding became febrile and anemic 12 days postsplenectomy. Babesia were visualized on blood smears, confirmed by polymerase chain reaction as B. microti. She developed respiratory failure despite initiation of clindamycin and quinine, and required 12 weeks of azithromycin and atovaquone before blood smear and polymerase chain reaction findings were negative. Serologic evidence of B. microti infection was identified in 1 associated blood donor and 1 other recipient of that donor's blood. Babesia infection can be asymptomat...

Acute laryngotracheitis after accidental aspiration of clindamycin

(Source: QJM)

Sufficient Release of Antibiotic by a Spacer 6 Weeks after Implantation in Two-stage Revision of Infected Hip Prostheses.

CONCLUSIONS: We concluded that, using the spacer technique described in this study, 6 weeks after spacer implantation, the concentrations of antibiotic are sufficient to treat a periprosthetic infection. PMID: 21678099 [PubMed - as supplied by publisher] (Source: Clinical Orthopaedics and Related Research)

CLINDAMYCIN HYDROCHLORIDEcapsule [Bryant Ranch Prepack]

Updated Date: Jun 15, 2011 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>

Aerobic vaginitis in pregnancy

Please cite this paper as: Donders G, Bellen G, Rezeberga D. Aerobic vaginitis in pregnancy. BJOG 2011; DOI: 10.1111/j.1471‚?ź0528.2011.03020.x.Aerobic vaginitis (AV) is an alteration in vaginal bacterial flora that differs from bacterial vaginosis (BV). AV is characterised by an abnormal vaginal microflora accompanied by an increased localised inflammatory reaction and immune response, as opposed to the suppressed immune response that is characteristic of BV. Given the increased local production of interleukin (IL)‚?ź1, IL‚?ź6 and IL‚?ź8 associated with AV during pregnancy, not surprisingly AV is associated with an increased risk of preterm delivery, chorioamnionitis and funisitis of the fetus. There is no consensus on the optimal treatment for AV in pregnant or non‚?źpregnant women, but ...

Clindamycin: Vascular injury (first report) following intra-arterial administration in an elderly patient: case report

(Source: Reactions)

CLINDAMYCIN (Clindamycin Phosphate) Injection, Solution [Hospira, Inc.]

Updated Date: Jun 13, 2011 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

Topical clindamycin 1% vs. linoleic acid‚?źrich phosphatidylcholine and nicotinamide 4% in the treatment of acne: a multicentre‚?źrandomized trial

SynopsisIt has been shown that topical linoleic acid rich‚?źphosphatidylcholine seems to be effective in normalization of follicular hyperkeratinization, whereas nicotinamide has an interesting anti‚?źinflammatory effect. However, little is known about their combined effect on acne. A multicentre, double‚?źblind, 12‚?źweek randomized vehicle and parallel‚?źactive control study was conducted by clinical and biophysical non‚?źinvasive measurements to evaluate the efficacy, tolerability and safety of a 4% nicotinamide‚?źphospholipidic (N‚?źPHCL) emulsion vs. 1% topical clindamycin phosphate applied once daily. Four percentage N‚?źPHCL cosmetic treatment resulted slightly superior to topical clindamycin with all the parameters studied for its better compliance and the global clinical improveme...

Molecular characterization of methicillin-resistant Staphylococcus aureus obtained from the anterior nares of healthy Korean children attending daycare centers

Conclusions: ST72 strains, which were previously found in hospital-associated MRSA, are now widely distributed in healthy Korean children. In addition, the prevalence of inducible resistance of clindamycin should be considered when selecting empirical antibiotics for community-associated MRSA infections in Korea. (Source: International Journal of Infectious Diseases)<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>

AUA Statement Regarding Infections Secondary To Transrectal Prostate Needle Biopsies

Research reports suggest that the rate of infectious complications, including sepsis, after transrectal prostate needle biopsy may be increasing. Recently published news articles highlighted these findings, and it is important for urologists to be aware of this issue. According to the AUA Best Practice Statement on Urologic Surgery Antimicrobial Prophylaxis, the antimicrobial of choice prior to prostate needle biopsy is a fluoroquinolone or a second- or third-generation cephalosporin. Alternative agents include an aminoglycoside plus metronidazole or clindamycin... (Source: Health News from Medical News Today)

CLINDAMYCIN (Clindamycin Phosphate) Injection, Solution, Concentrate [Hospira, Inc.]

Updated Date: Jun 9, 2011 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

CLINDAMYCIN HYDROCHLORIDEcapsule [Mylan Pharmaceuticals Inc.]

Updated Date: Jun 6, 2011 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

Antimicrobial resistance and prevalence of resistance genes in intestinal Bacteroidales strains

CONCLUSIONS: Our results indicate an increase in the resistance to several antibiotics in intestinal Bacteroides spp. and Parabacteroides distasonis and demonstrate that these microorganisms harbor antimicrobial resistance genes that may be transferred to other susceptible intestinal strains. (Source: Clinics)

Variable antibiotic susceptibility patterns among Streptomyces species causing actinomycetoma in man and animals

Conclusions: Saprophytic Streptomyces spp. cause actinomycetoma in man and animal belong to separate phenotypes and have a wide range of susceptibility patterns to antimicrobial agents, which pose a lot of difficulties in selecting effective in vivo treatment for actinomycetoma. (Source: Annals of Clinical Microbiology and Antimicrobials)<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>

Antibiotic treatment for acute haematogenous osteomyelitis of childhood: Moving towards shorter courses and oral administration

Abstract: Acute haematogenous osteomyelitis (AHOM) of childhood usually affects the long bones of the lower limbs. Although almost any agent may cause AHOM, Staphylococcus aureus is the most common bacterium, followed by Streptococcus pneumoniae and, in some countries, Salmonella spp. and Kingella kingae. Magnetic resonance imaging (MRI) has improved the diagnostic accuracy of traditional radiography and scintigraphy. Except for the pre-treatment diagnostic sample from bone before the institution of antibiotic therapy, no other surgery is usually required. Traditionally, non-neonatal AHOM has been treated with a 1‚??3-month course of antibiotics, including an intravenous (i.v.) phase for the first weeks, but recent prospective randomised studies challenge this approach. For most uncomplica...

CLINDAMYCIN HYDROCHLORIDEcapsule [Teva Pharmaceuticals USA Inc]

Updated Date: Jun 2, 2011 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

[Antimicrobial susceptibility of methicillin-resistant Staphylococcus aureus strains from outpatient individuals.]

Conclusions: CA-MRSA isolates percentage increased along the period of the study. The majority were obtained from skin and soft tissue specimens. The most commonly associated antimicrobial resistance was to fluoroquinolones, erythromycin, tobramycin and clindamycin. An understanding of the CAMRSA epidemiology is important to prevent these organisms from becoming endemic in the world. PMID: 21667001 [PubMed - as supplied by publisher] (Source: Revista Espanola de Quimioterapia)

Characterization of Staphylococcus aureus strains isolated from raw milk of bovine subclinical mastitis in Tehran and Mashhad.

Authors: Sahebekhtiari N, Nochi Z, Eslampour MA, Dabiri H, Bolfion M, Taherikalani M, Khoramian B, Zali MR, Emaneini M Staphylococcus aureus is considered one of the most important food borne pathogens.A total of 111 isolates of S. aureus were cultured from raw milk samples during January 2009 to June 2009 from Tehran and Mashhad. The coagulase gene polymorphism and the prevalence of classical enterotoxin genes of S. aureus strains were determined by PCR-RFLP (restriction fragment length polymorphism) and Multiplex-PCR. Disk diffusion method was used to determine the susceptibility of isolates to antimicrobial agents as instructed by Clinical and Laboratory Standards Institute.Sixty-seven % of the isolates harboured one or more enterotoxin genes. The most prevalent gene was sec, found ...

Prevalence of Methicillin‚?źResistant Staphylococci on a Farm: Staff can Harbour MRS When Animals Do Not

SummaryThe aim of this work was to establish the prevalence of methicillin‚?źresistant Staphylococci (MRS) in the animals and staff of a teaching and research farm. Samples of dairy cattle (36), beef cattle (26), sheep (19), horses (21), pigs (23), goats (23) and humans (13) were collected and screened for the presence of MRS. The detection of mecA gene was performed by PCR to determine the resistance of the samples to methicillin. Antimicrobial‚?źresistance testing to penicillin, meropenem, ceftriaxone, cephalothin, oxacillin, levofloxacin, enrofloxacin, chloramphenicol, ciprofloxacin, gentamicin, clindamycin, erytromycin, linezolid, sulfamethoxazole/trimethoprim, tetracycline, doxycycline and vancomycin was performed on the mecA+ isolates. From the 161 samples, four methicillin‚?źresista...<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>

CLINDAMYCIN (Clindamycin Phosphate) Injection, Solution [Hospira, Inc.]

Updated Date: May 26, 2011 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

Combination of azelaic acid 5% and clindamycin 2% for the treatment of acne vulgaris.

Discussion and conclusion: The profound reduction in lesion count and ASI by combination therapy with AA-Clin gel in comparison to individual treatment with 5% AA or Clin 2% suggested the combination formula as an effective alternative in treatment of acne vulgaris. PMID: 21612319 [PubMed - as supplied by publisher] (Source: Cutaneous and Ocular Toxicology)

Demodex Folliculitis

A 20-year-old woman presents to the office for a refill of her birth control prescription. She had no gynecological complaints and was generally in good health. Her only issue was the presence of multiple pustules over her mid-forehead that appeared acutely, and she was otherwise asymptomatic except for their presence and persistence. The patient had been treated with topical acne medications including a benzoyl peroxide wash, clindamycin gel topical 1%, and tretinoin cream 0.05% by her primary care physician with no success. On examination, the patient had multiple diffuse erythematous pustules primarily over her mid-forehead (). A dermatology consult was ordered. (Source: Journal of Pediatric and Adolescent Gynecology)

Viral Reactivation and Drug Rash: Causal or Casual Association?

I read with interest the article, ‚??Drug Rash with Eosinophilia and Systemic Symptoms Syndrome Associated with Clindamycin,‚?Ě by Tian et al. However, the authors may have missed the opportunity to address an important issue on viral reactivation or persistent viral infection in the pathogenesis of drug rash with eosinophilia and systemic symptoms syndrome, more so in the wake of a recent episode of infectious mononucleosis in the patient. (Source: The American Journal of Medicine)

clindamycin - topical, Cleocin T, Clinda-Derm

Title: clindamycin - topical, Cleocin T, Clinda-DermCategory: MedicationsCreated: 3/2/2005Last Editorial Review: 5/24/2011 (Source: MedicineNet Medications General)<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>

clindamycin - injection, Cleocin

Title: clindamycin - injection, CleocinCategory: MedicationsCreated: 3/2/2005Last Editorial Review: 5/24/2011 (Source: MedicineNet Hepatitis C General)

Detection and characterisation of SCCmec remnants in multiresistant methicillin-susceptible Staphylococcus aureus causing a clonal outbreak in a Swedish county

This study demonstrates the presence of a pseudo-SCC element resembling SCCmec type II among MR-MSSA, suggesting possible derivation from MRSA. The presence of SCCmec remnants should always be considered when SCCmec typing is used for MRSA detection, and may not be suitable in locations with a high prevalence of MR-MSSA, since this might give a high number of false-positive results. Content Type Journal ArticlePages 1-7DOI 10.1007/s10096-011-1286-yAuthors M. Lindqvist, Department of Infection Control, Link√∂ping University Hospital, Link√∂ping, SwedenB. Isaksson, Department of Infection Control, Link√∂ping University Hospital, Link√∂ping, SwedenC. Grub, Department of Microbiology, Oslo University Hospital, Oslo, NorwayT. √?. Jonassen, Department of Microbiology, Oslo University Hos...

CLINDAMYCIN HYDROCHLORIDEcapsule [Rebel Distributors Corp]

Updated Date: May 17, 2011 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

Genetic diversity, antimicrobial resistance and toxigenic profiles of Bacillus cereus isolated from food in Brazil over three decades.

In this study we analyzed 97 foodborne B. cereus sensu stricto strains isolated in Brazil in the 1980's, 1990's and 2000's in order to investigate the genetic diversity (assessed by Rep-PCR), antimicrobial resistance and toxigenic profiles (presence of hblA, hblC and hblD; nheA, nheB and nheC as well as cytK, ces and entFM genes) of such strains. The majority of the strains (79, 81.4%) were ő≤-hemolytic. The NHE complex was found in 82 strains (84.5%) and HBL complex was found in 61 (62.9%) strains. All strains were negative to ces. The cytK-2 gene was found in 44 (45.4%) strains. The predominant toxigenic pattern was type I (32, 33%) which included strains positive for all toxin genes but ces. Computer assisted cluster analysis of Rep-PCR profiles showed a high genetic diversity. Seven ma...

Acute Upper Airway Obstruction

Abstract&nbsp;&nbsp;Upper airway obstruction is defined as blockage of any portion of the airway above the thoracic inlet. Stridor, suprasternal retractions, and change of voice are the sentinel signs of upper airway obstruction. Most of the common causes among children presenting to emergency department are of acute infectious etiology. Among these, croup is the commonest while diphteria remains the most serious life-threatening cause. Recent reports indicate that bacterial tracheitis has become increasingly common. In ER evaluation the key clinical data in determining the cause and the site of obstruction are the onset, presence of fever, character of the stridor, retractions, the voice and the ability to handle secretions. After assessment of the severity of respiratory distress a...<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>

Two paediatric cases of skin and soft-tissue infections due to clindamycin-resistant Staphylococcus aureus carrying a plasmid-encoded vga(A) allelic variant for a putative efflux pump

Abstract: Two clinical Staphylococcus aureus isolates were investigated due to their unusual antimicrobial susceptibility pattern, i.e. erythromycin-susceptible but clindamycin-resistant. These isolates harboured identical copies of a plasmid-borne vga(A)LC gene not previously described in S. aureus. The native plasmids carrying vga(A)LC were transferable to a susceptible laboratory strain of S. aureus in vitro, in which they conferred resistance patterns similar to the parent isolates. (Source: International Journal of Antimicrobial Agents)

Bilateral Peritonsillar Abscesses: A Case Presentation and Review of the Current Literature with regard to the Controversies in Diagnosis and Treatment

We report the case of a 19-year-old girl, treated in the emergency room with a bilateral diagnostic needle aspiration followed by bilateral incision and drainage along with intravenous clindamycin plus anti-inflammatory agents and hydration. Following treatment, the patient progressively experienced a marked alleviation of her odynophagia. She was discharged 48 hours later on a 10-day course of clindamycin. (Source: Advances in Pharmacological Sciences)

VELTIN (Clindamycin Phosphate And Tretinoin) Gel [Stiefel Laboratories Inc]

Updated Date: May 5, 2011 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

Progressive macular hypomelanosis, excellent response with narrow‚?źband ultraviolet B phototherapy

We present the case of a 13‚?źyear‚?źold girl with hypopigmented lesions on the trunk and limbs that had progressed over 1 year and that were diagnosed as PMH. The patient was initially treated with topical clindamycin and benzoyl peroxide. However, little improvement was seen and treatment was then started with NBUVB phototherapy. After 25 sessions, with a total cumulative dose of 18‚??J/cm2, the patient showed almost total repigmentation of the lesions. The treatment of PMH is often difficult, and very little is currently known about the treatment response in this disorder, as most reports have very small series of patients with a short disease progression time. NBUVB phototherapy has been shown to be effective, as seen in our patient, although in many cases, there is recurrence after th...

DUAC (Clindamycin Phosphate And Benzoyl Peroxide) Gel DUAC (Clindamycin Phosphate And Benzoyl Peroxide) Gel [Stiefel Laboratories Inc]

Updated Date: May 2, 2011 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>

EVOCLIN (Clindamycin Phosphate) Aerosol, Foam [Stiefel Laboratories Inc]

Updated Date: May 2, 2011 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

Molecular Epidemiologic Analysis of Methicillin-Resistant Staphylococcus aureus Isolates from Bacteremia and Nasal Colonization at 10 Intensive Care Units: Multicenter Prospective Study in Korea.

Authors: Kwon JC, Kim SH, Park SH, Choi SM, Lee DG, Choi JH, Park C, Shin NY, Yoo JH We investigated molecular epidemiology of methicillin-resistant Staphylococcus aureus (MRSA) isolated at 10 intensive care units (ICUs) in Korea. MRSA isolates from bacteremia and nasal colonization were collected prospectively from October 2008 through May 2009 at 10 University-affiliated hospital ICUs. A total of 83 and 175 MRSA strains were isolated from bacteremia and nasal colonization, respectively. Acquired group accounted for 69.9% (n = 58) of bacteremia and 73.1% (n = 128) of nasal colonization. Pulsed-field gel electrophoresis (PFGE) type B (SCCmec type II/ST5) was dominant in the acquired group followed by PFGE type D (SCCmec type IVA/ST72; a community genotype). Seven of 58 (12.1%) acquired...

Antibiotic resistance and adhesion potential of Bacteroides fragilis clinical isolates from Cape Town, South Africa.

Authors: Galv√£o BP, Meggersee RL, Abratt VR The minimum inhibitory concentrations of 23 Bacteroides fragilis clinical isolates from Cape Town, South Africa, were established using the E-test method. Eight percent of the strains were found to be highly resistant to metronidazole (‚?•256¬†mg/L) imipenem and cefoxitin. This is an 8% increase in resistance compared to the previous metronidazole susceptibility screening performed in South Africa in 1998. Clindamycin was the most effective antibiotic with all strains showing sensitivity. Most of the strains (65%) were tetracycline resistant, while one strain, B.¬†fragilis GSH15, showed multidrug resistance to metronidazole, imipenem, cefoxitin and tetracycline. PCR screening revealed that none of the strains contained any of the published n...

Diagnostic and Therapeutic Evaluation of Community-acquired Methicillin-resistant Staphylococcus Aureus (MRSA) Skin and Soft Tissue Infections in the Emergency Department

Conclusions: Cephalexin was often added to cover for potential cellulitis due to Streptococcus spp., however, the surrounding erythema may simply be an extension of the CA-MRSA infection. Department-specific antibiograms are useful in guiding empiric antibiotic selection and may help providers judiciously prescribe antibiotics only when necessary. (Source: The Journal of Emergency Medicine)

CLINDAMYCIN (Clindamycin) Injection, Solution [General Injectables Vaccines, Inc]

Updated Date: Apr 26, 2011 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>

CLINDAMYCIN PHOSPHATEaerosol, Foam [Perrigo New York Inc]

Updated Date: Apr 25, 2011 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

CLINDAMYCIN HYDROCHLORIDEcapsule [American Health Packaging]

Updated Date: Apr 22, 2011 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

CLINDAMYCIN HYDROCHLORIDEcapsule [Lannett Company, Inc.]

Updated Date: Apr 19, 2011 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

Bacteriological findings and antimicrobial resistance in odontogenic and non-odontogenic chronic maxillary sinusitis.

In this study, 20% of chronic maxillary sinusitis were associated with a dental origin, and sinus lift procedures were the main etiological factor. Our microbiological findings showed that all specimens from chronic maxillary sinusitis were polymicrobial. Sixty aerobes and 75 anaerobes were recovered from the 47 cases of non-odontogenic sinusitis (2.9 bacteria/specimen); 15 aerobes and 25 anaerobes were isolated from the 12 patients with odontogenic sinusitis (3.3 bacteria/specimen). The predominant aerobes were Staphylococcus aureus (27) and Streptococcus pneumoniae (16), while the more frequent anaerobes were Peptostreptococcus spp. (31) and Prevotella spp. (30). Haemophilus influenzae and Moraxella catarrhalis were absent in sinusitis associated with a dental origin. Overall, 22% of S. ...

Toxoplasmic encephalitis in AIDS-patients before and after the introduction of highly active antiretroviral therapy (HAART)

Abstract&nbsp;&nbsp;Toxoplasmic encephalitis (TE) continues to be a severe health problem despite the introduction of highly active antiretroviral therapy (HAART). To identify predictors for development of TE we compared demographic, clinical and diagnostic variables in AIDS patients with TE before (n‚??=‚??102) or after the introduction (n‚??=‚??70) of HAART at the Charit√© University Medicine in Berlin, Germany. Interestingly, patient characteristics did not differ significantly in the pre- and post-HAART groups. Sixty-eight percent of patients had CD4-cell counts of &lt;50/őľl. Outcome after treatment with pyrimethamin plus sulfonamides or clindamycin (47% each) did not differ; adverse reactions were more frequent in patients receiving sulfonamides than in those receiving clindamyc...<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>

Cephalexin is as effective as clindamycin for the treatment of uncomplicated soft tissue and skin infections in children

Chen AE, Carroll KC, Diener-West M, Ross T, Ordun J, Goldstein MA, et al. Randomized controlled trial of cephalexin versus clindamycin for uncomplicated pediatric skin infections. Pediatrics 2011;127:e573-80. (Source: The Journal of Pediatrics)

Antibiotics, Acne, and Staphylococcus aureus Colonization [Study]

Conclusion&nbsp; Unlike current dogma about the long-term use of antimicrobial agents, the prolonged use of tetracycline antibiotics commonly used to treat acne lowered the prevalence of colonization by S aureus and did not increase resistance to the tetracycline antibiotics. (Source: Archives of Dermatology)

Predominance of ST320 among Streptococcus pneumoniae serotype 19A isolates from 10 Asian countries

Conclusions Although diverse clones were identified among 19A S. pneumoniae isolates, MDR ST320 was the predominant clone in Asian countries. Its predominance, even in countries with no or low coverage of PCV7, may indicate that its emergence and dissemination was due to more than just vaccine selection pressure in Asian countries. A longitudinal investigation of the change of serotypes and genotypes since the introduction of PCV7 is required to understand the emergence and dissemination mechanisms of a certain clone of 19A S. pneumoniae isolates. (Source: Journal of Antimicrobial Chemotherapy)

Early life-threatening lactic acidosis following a single infusion of linezolid

An 81-year-old Caucasian man was admitted to our Intensive Care Unit (ICU) for acute respiratory failure. He had a history of hepatitis-C-associated cryoglobulinaemia without cirrhosis, treated with corticosteroids (prednisone 5mg/day). The patient had been hospitalised 3 weeks before for an acute nephritic syndrome that was successfully treated with high doses of corticosteroids. Three weeks later the patient developed afebrile acute respiratory failure requiring mechanical ventilation. Chest radiography showed consolidation of the right upper lobe. Staphylococcus aureus was recovered from bronchoalveolar lavage fluid (105colony-forming units/mL). The patient was treated with cloxacillin (2g every 8h) and clindamycin (600mg every 8h) for 7 days. The evolution was favourable and weaning fr...

CLINDAMYCIN PHOSPHATEsolution [Physicians Total Care, Inc.]

Updated Date: Apr 8, 2011 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>

CLINDAMYCIN HYDROCHLORIDEcapsule [REMEDYREPACK INC. ]

Updated Date: Apr 7, 2011 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

Perioperative, Postoperative, and Prophylactic Use of Antibiotics in Alloplastic Total Temporomandibular Joint Replacement Surgery: A Survey and Preliminary Guidelines

Conclusion: The evidence provided from the present small study survey and a review of the orthopedic data could provide the opportunity to develop guidelines for the preoperative, intraoperative, and postoperative antibiotic management for TMJ TJRs and spur additional research into this important area of patient management. (Source: Journal of Oral and Maxillofacial Surgery)

Treatment of abnormal vaginal flora in early pregnancy with clindamycin for the prevention of spontaneous preterm birth: a systematic review and metaanalysis

The purpose of this study was to determine whether the administration of clindamycin to women with abnormal vaginal flora at (Source: American Journal of Obstetrics and Gynecology)

Evaluation of resistance mechanisms and serotype and genotype distributions of macrolide-resistant strains in clinical isolates of Streptococcus pneumonia in AydńĪn, Turkey

Abstract&nbsp;&nbsp;Macrolide resistance mechanisms in 89 Streptococcus pneumoniae strains isolated from several clinical samples between February 2007 and May 2009 were investigated. Erythromycin resistance was noted in 35 (40%) S. pneumoniae strains. In these strains, the most frequent resistance phenotype was cMLSB (74%), and the most frequent resistance genotype was ermB (82%). Both ermB and mefA genes were positive in 20% of macrolide-resistant strains. While no resistance to vancomycin, linezolid and telithromycin was noted in 89 S. pneumoniae strains, 12 (13%) strains were penicillin resistant, 26 (30%) strains were clindamycin resistant, 35 (40%) were azithromycin resistant, 32 (36%) strains were tetracycline resistant, and 1 (1%) strain was levofloxacin resistant. The serotype ...

CA-MRSA Skin Infections May Respond to Cephalexin

Cephalexin and clindamycin have comparable effectiveness for the treatment of uncomplicated pediatric skin and soft tissue infections caused by community-acquired methicillin-resistant Staphylococcus aureus, findings from a randomized double-blind study of 200 patients suggest. (Source: Rheumatology News)<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>

An investigation of sub-type diversity of clinical isolates of Irish Clostridium difficile ribotypes 027 and 078 by repetitive-extragenic palindromic PCR.

Authors: Solomon K, Murray S, Scott L, McDermott S, Drudy D, Martin AJ, O'Donoghue C, Skally M, Burns K, Fenelon L, Fitzpatrick F, Kyne L, Fanning S We used a rep-PCR sub-typing method (DiversiLab) in conjunction with ribotyping, toxinotyping and antimicrobial susceptibility testing to detect sub-types within ribotypes 027 and 078. Stratifying molecular techniques with information regarding infection origin, location and date of acquisition, enabled an investigation of sub-type diversity, persistence over time and specificity to healthcare facilities. Clinical isolates of ribotypes 027 (toxinotype III) (n=30) and 078 (toxinotype V) (n=23) were provided by healthcare facilities across the Republic of Ireland over two months in 2006 and 2009. Ribotype 027 isolates were significantly more...

Vaginitis: diagnosis and treatment.

Authors: Hainer BL, Gibson MV Bacterial vaginosis, trichomoniasis, and vulvovaginal candidiasis are the most common infectious causes of vaginitis. Bacterial vaginosis occurs when the normal lactobacilli of the vagina are replaced by mostly anaerobic bacteria. Diagnosis is commonly made using the Amsel criteria, which include vaginal pH greater than 4.5, positive whiff test, milky discharge, and the presence of clue cells on microscopic examination of vaginal fluid. Oral and topical clindamycin and metronidazole are equally effective at eradicating bacterial vaginosis. Symptoms and signs of trichomoniasis are not specific; diagnosis by microscopy is more reliable. Features of trichomoniasis are trichomonads seen microscopically in saline, more leukocytes than epithelial cells, positive...

Antimicrobial susceptibility of Clostridium perfringens isolates of bovine, chicken, porcine, and turkey origin from Ontario.

Authors: Slaviń? D, Boerlin P, Fabri M, Klotins KC, Zoethout JK, Weir PE, Bateman D Antimicrobial susceptibilities and toxin types were determined for 275 Clostridium perfringens isolates collected in Ontario in the spring of 2005. Minimal inhibitory concentrations (MICs) of C. perfringens isolates for 12 antimicrobials used in therapy, prophylaxis, and/or growth promotion of cattle (n = 40), swine (n = 75), turkeys (n = 50), and chickens (n = 100) were determined using the microbroth dilution method. Statistical analyses and MIC distributions showed reduced susceptibility to bacitracin, clindamycin, erythromycin, florfenicol, and tetracycline for some isolates. Reduced susceptibility to bacitracin was identified in chicken (64%) and turkey (60%) isolates. Swine isolates had predominan...

Dextromethorphan overdose and psychosis

2 out of 5 stars Cough Syrup Psychosis. Amaladoss A, O&#8217;Brien S. CJEM 2011;13:53-56. Abstract This case report describes a 20-year-old woman who presented with &#8220;bizarre somatic delusions&#8221;,complaining that a physician had injected &#8220;Salium&#8221; into her anus.  She had disorganized thinking, dissociative perception, and paranoid ideation. She had been seen in the emergency department on 5 consecutive days complaining of sore throat, for which she had been prescribed oxycodone, acetaminophen, and clindamycin.  Monospot, strep culture, and CT neck were negative. She had no psychiatric history, but reported taking &#8220;frequent tablesppons of cough syrup a day&#8221;.  Her urine toxicology screen was positive for opiates, acetaminophen, benzodiazepines, and tricycl...

[Methicillin-resistant Staphylococcus aureus disease in Panama.]

CONCLUSIONS: The incidence of MRSA infections was low compared with other regions. We recommend active surveillance in order to establish measures to prevent nosocomial infections and treatment guidelines based on local epidemiological criteria. PMID: 21454143 [PubMed - as supplied by publisher] (Source: Anales de Pediatria)<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>

Clostridium difficile in finishing beef cattle: Transient fecal shedding and limited animal-to-animal transmission in a naturally infected feedlot.

Authors: Rodriguez-Palacios A, Pickworth C, Loerch S, Lejeune JT To longitudinally assess fecal shedding and animal-to-animal transmission of Clostridium difficile among finishing feedlot cattle as a risk for beef carcass contamination, we tested 186¬Ī12 steers (1,369 samples) in an experimental feedlot facility during the finishing period and at harvest. Clostridium difficile was isolated from 12.9% of steers on arrival (24/186; 0 to 33% among 5 suppliers). Shedding decreased to undetectable levels a week later (0%, P &lt; 0.001); and remained low (&lt;3.6%) until immediately prior to shipment for harvest (1.2%). Antimicrobial use did not increase fecal shedding despite treatment of 53% of animals for signs of respiratory disease. Animals shedding C. difficile on arrival, however, had...

Vaginal retention of locally administered clindamycin

Eriksson K, Larsson P‚?źG, Nilsson M, Forsum U. Vaginal retention of locally administered clindamycin. APMIS 2011.Since bacterial vaginosis (BV) is characterized by a lack of, or very few, lactobacilli and high numbers of small, mostly anaerobic bacteria, an obvious treatment modality would be eradication of the BV‚?źassociated bacterial flora followed by reintroduction of lactobacilli vaginally. As probiotic treatment with lactobacilli is one tool for improving the cure rate when treating BV, it is necessary to know the length of time after treatment that clindamycin can be found in the vagina and if this could interfere with the growth of the probiotic lactobacilli. We evaluated the vaginal concentration of clindamycin in 12 women for 8‚??days to obtain data on the concentration of clind...

CLEOCIN PHOSPHATE (Clindamycin Phosphate) Injection, Solution [Pharmacia And Upjohn Company]

Updated Date: Mar 23, 2011 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

Efficacy of topical combination of benzoyl peroxide 5% and clindamycin 1% for the treatment of progressive macular hypomelanosis: a randomized, doubleblind, placebo-controlled trial

FUNDAMENTOS: A hipomelanose macular progressiva √© uma dermatose sem etiologia definida. N√£o h√° consenso ou medica√ß√£o de primeira linha para o seu tratamento e os tratamentos utilizados s√£o pouco eficazes. OBJETIVO: Avaliar a efic√°cia terap√™utica da combina√ß√£o t√≥pica de per√≥xido de benzo√≠la 5% e clindamicina 1% associada √† exposi√ß√£o solar para o tratamento da hipomelanose macular progressiva. MATERIAIS E M√?TODOS: Trata-se de um estudo randomizado, duplo-cego, placebo-controlado, no qual os pacientes foram divididos em dois grupos: o Grupo A utilizou a combina√ß√£o t√≥pica de per√≥xido de benzo√≠la 5% e clindamicina 1% e o Grupo B usou um creme gel como placebo. Os pacientes foram orientados √† exposi√ß√£o solar di√°ria, avaliados e fotografados sistematicamente. Os dados co...

DUAC (Clindamycin Phosphate And Benzoyl Peroxide) Gel DUAC (Clindamycin Phosphate And Benzoyl Peroxide) Gel [Stiefel Laboratories Inc]

Updated Date: Mar 21, 2011 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>

Quorum sensing inhibitors increase the susceptibility of bacterial biofilms to antibiotics in vitro and in vivo.

Authors: Brackman G, Cos P, Maes L, Nelis HJ, Coenye T Although the exact role of quorum sensing (QS) in various stages of biofilm formation, maturation and dispersal, and in biofilm resistance is not entirely clear, the use of QS inhibitors (QSI) has been proposed as a potential anti-biofilm strategy. We have investigated whether QSI enhance the susceptibility of bacterial biofilms to treatment with conventional antimicrobial agents. The QSI used in our study target the acyl-homoserine lactone based QS system present in Pseudomonas aeruginosa and Burkholderia cepacia complex organisms (baicalin hydrate, cinnamaldehyde), or the peptide-based system present in Staphylococcus aureus (hamamelitannin). The effect of tobramycin (P. aeruginosa, B. cepacia complex) and clindamycin or vancomyc...

Effect of Antibiotic Treatment on Establishment and Elimination of Intestinal Colonization with KPC-producing Klebsiella pneumoniae in Mice.

Authors: Perez F, Pultz MJ, Endimiani A, Bonomo RA, Donskey CJ Understanding the impact of antibiotics on the intestinal reservoir of KPC carbapenemase-producing Klebsiella pneumoniae (KPC-Kp) is important to prevent its emergence. We used a mouse model to examine the effect of antibiotic treatment on establishment and elimination of intestinal colonization with KPC-Kp. Mice (10 per group) received subcutaneous antibiotics daily for 8 days. On day 3 of treatment, 10(3) CFUs of KPC-Kp were given orogastrically and concentrations of KPC-Kp in stool were monitored. Additional experiments assessed the effects of antibiotic treatment on concentrations of total anaerobes and Bacteroides spp. in stool, and the efficacy of orogastric gentamicin and polymyxin E in suppressing KPC-Kp colonizatio...

Prevalence and antimicrobial resistance of salmonella serovars from chicken carcasses in northern greece

This study was conducted to determine the prevalence and antimicrobial resistance of Salmonella isolates recovered from chicken carcasses in slaughterhouses in Northern Greece. A total of 150 broiler samples were examined for Salmonella spp. and the results were reported as presence or absence of Salmonella spp. The samples were neck‚?źskin taken from 450 poultry carcasses at four slaughterhouses in Northern Greece.Salmonella was present in 56 (37%) of the samples tested. A total of 142 isolates belonging to six serovars were detected. The most common serotype identified was Salmonella blockley (73.2%), followed by Salmonella paratyphi B (16.9%), Salmonella bredeney (6.3%), Salmonella neftenbach (1.4%), Salmonella hadar (1.4%) and Salmonella thompson (0.7%).Salmonella spp. isolated from ch...

Rifampicin and clindamycin for hidradenitis

To the Editor: We read with interest the recent article by Grant et¬†al on infliximab therapy for patients with moderate to severe hidradenitis suppurativa (HS) in which the authors state that ‚??currently available medical treatments are minimally effective in cases of moderate to severe HS‚?Ě. (Source: Journal of the American Academy of Dermatology)

VELTIN (Clindamycin Phosphate And Tretinoin) Gel [Stiefel Laboratories Inc]

Updated Date: Mar 17, 2011 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>

Characterization and antimicrobial susceptibility of Clostridium difficile strains isolated from diarrhoeal adult patients hospitalized in two university hospitals in Poland, 2004-2006.

In conclusion, an increase of non-027 binary toxin producing C. difficile strains has been observed in Poland, but C. difficile PCR ribotype 017 remains a major circulating type. PMID: 21415206 [PubMed - as supplied by publisher] (Source: Journal of Medical Microbiology)

Variation in erythromycin and clindamycin resistance patterns between New Zealand and Australian group B streptococcus isolates

Conclusion:‚?? Erythromycin and clindamycin resistance among invasive neonatal GBS isolates has emerged in both New Zealand and Australia over the past decade and is consistent with global trends in GBS resistance patterns. Although regional variations exist, these findings should be considered when implementing intrapartum GBS prevention strategies. (Source: The Australian and New Zealand Journal of Obstetrics and Gynaecology)

CLEOCIN PHOSPHATE (Clindamycin Phosphate) Injection, Solution [Pharmacia And Upjohn Company]

Updated Date: Mar 14, 2011 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

CLINDAREACH (Clindamycin Phosphate) Solution [DUSA Pharmaceuticals, Inc.]

Updated Date: Mar 14, 2011 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

Changes in Antibiotic Distribution in Pancreatitis.

Authors: Fanning KJ, Robertson TA, Prins JB, Roberts MS This work sought to define how pancreatitis affected antibiotic distribution in a perfused rat pancreas model. The distribution kinetics of four antibiotics were examined in control and diseased animals. Meropenem and piperacillin distributed into the extracellular space and their distribution kinetics were unaffected by pancreatitis. In contrast, ciprofloxacin showed a reduced uptake into pancreatitis cells and clindamycin showed a reduced distribution in pancreatitis cells. PMID: 21402839 [PubMed - as supplied by publisher] (Source: Antimicrobial Agents and Chemotherapy)<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>

In vitro biofilm formation and bactericidal activities of methicillin-resistant Staphylococcus aureus clones prevalent in Korea

Abstract: The purpose of this study was to quantify the biofilm formations of various methicillin-resistant Staphylococcus aureus (MRSA) clones (ST1, ST5, ST72, ST89, ST239, and ST254) and to evaluate the in vitro activities of antibiotics. Of 86 MRSA isolates tested, 44 isolates (51.2 %) formed biofilms, including 8 strong biofilm producers (7 isolates of ST72 and 1 isolate of ST89). The planktonic MICs, minimal bactericidal concentrations, and minimum biofilm eradication concentrations (MBECs) of 6 antibiotics (clindamycin, gentamicin, linezolid, vancomycin, daptomycin, and tigecycline) were measured for 8 MRSA isolates. The planktonic isolates were susceptible to all agents, with daptomycin being the most effective, followed by gentamicin and vancomycin. However, clindamycin, linezolid,...

Activity of the efflux pump inhibitor phenylalanine-arginine ő≤-naphthylamide against the AdeFGH pump of Acinetobacter baumannii

In this study, the activity of the efflux pump inhibitor (EPI) phenylalanine-arginine ő≤-naphthylamide (PAő≤N) against the RND efflux pump AdeFGH of A. baumannii was analysed. The adeFGH operon was cloned under the control of the tac promoter and was introduced in single copy into a surrogate Pseudomonas aeruginosa strain that is devoid of its six native efflux pumps. Isopropyl-ő≤-d-thiogalactopyranoside (IPTG) was used to induce expression of the pump and the sensitivity of strains expressing the adeFGH operon to PAő≤N was analysed in the surrogate strain and in clinical isolates of A. baumannii by measuring the minimum inhibitory concentrations of trimethoprim, chloramphenicol and clindamycin (substrates of AdeFGH) in the presence and absence of PAő≤N. PAő≤N was found to inhibit the abil...

Necrotizing Fasciitis Following BCG Vaccination.

We report a newborn with methicillin-resistant Staphylococcus aureus mediated necrotizing fasciitis after Bacilli-Calmette-Guerin vaccination. Radical debridement of the affected area coupled with twice daily surgical honey dressing and intravenous vancomycin and clindamycin resulted in satisfactory healing. PMID: 21478557 [PubMed - in process] (Source: Indian Pediatrics)

Persistent babesiosis in a stem cell transplant recipient

Babesiosis in humans is a malaria-like infection caused primarily by the protozoa Babesia microti. Infection typically occurs during the summer and fall months, when the tick vector is prevalent, and is characterized by erythrocyte invasion and destruction . Many patients have asymptomatic disease and recover spontaneously after babesia infection and those that do become symptomatic often improve following a short (7‚??10 days) course of therapy with either azithromycin and atovaquone or clindamycin and quinine . However, immunosuppressed and splenectomized patients have both been shown to be at risk for more severe disease and in some instances these patients have had prolonged and apparently refractory disease despite appropriate antiparasitic coverage . (Source: Leukemia Research)

Randomized Controlled Trial of Cephalexin Versus Clindamycin for Uncomplicated Pediatric Skin Infections

CONCLUSIONS: There is no significant difference between cephalexin and clindamycin for treatment of uncomplicated pediatric SSTIs caused predominantly by CA-MRSA. Close follow-up and fastidious wound care of appropriately drained, uncomplicated SSTIs are likely more important than initial antibiotic choice. (Source: PEDIATRICS)<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>

Cellulitis unresponsive to antibiotics.

Authors: Withrow RA, Shenenberger D, Kalish VB, Krivda S Oral cephalexin didn't work, so we started the patient on IV vancomycin and clindamycin, followed by gatifloxacin. But the lesions worsened. PMID: 21369557 [PubMed - in process] (Source: The Journal of Family Practice)

Perioral dermatitis

Abstract: Perioral dermatitis is a relatively common inflammatory disorder of facial skin, often appearing in patients with rosacea, but with less inflammation. A typical perioral dermatitis presentation occurs with the eruption of papules and pustules confined to the nasolabial folds and the skin of the chin. Clinically, small pink papules and pustules may recur over weeks to months, sometimes with fine scales. The differential diagnosis includes seborrheic dermatitis, systemic lupus erythematosus, acne vulgaris, lupus miliaris disseminatus faciei, steroid-induced rosacea, and even basal cell carcinoma. The histopathology is similar to that found in rosacea. With advancement of the process, a perivascular and perifollicular lymphohistiocytic infiltrate develops. Sebaceous hyperplasia may ...

Antimicrobial resistance profiles and genetic characterisation of macrolide resistant isolates of Streptococcus agalactiae.

In this study, 100 clinical isolates of Streptococcus agalactiae recovered from genitourinary tract specimens of non-pregnant individuals living in Rio de Janeiro were submitted for antimicrobial susceptibility testing, detection of macrolide resistance genes and evaluation of the genetic diversity of erythromycin-resistant isolates. By agar diffusion method, all isolates were susceptible to ceftazidime, penicillin and vancomycin. Isolates were resistant to levofloxacin (1%), clindamycin (5%), erythromycin (11%) and tetracycline (83%) and were intermediated to erythromycin (4%) and tetracycline (6%). Erythromycin-resistant and intermediated isolates presented the following phenotypes: M (n = 3), constitutive macrolide-lincosamide-streptogramin B (MLS B, n = 5) and inductive MLS B (n = 7). ...

Vital Signs: Safety: Wound Care May Matter More Than Antibiotics

In a study of treatments for skin infections, the choice between clindamycin and cephalexin made no difference. (Source: NYT Health)<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>

Comparison of the clinical efficacy of NBUVB and NBUVB with benzoyl peroxide/clindamycin in progressive macular hypomelanosis

Conclusions‚?? Although recurrence occurred in some patients, NBUVB treatment appears to be a safe and useful modality for the treatment of PMH. (Source: Journal of the European Academy of Dermatology and Venereology)

CLINDACIN P (Clindamycin Phosphate) Swab CLINDACIN PAC (Clindamycin Phosphate) Swab [Medimetriks Pharmaceuticals, Inc.]

Updated Date: Feb 22, 2011 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

Group A streptococcal vaginitis: an unrecognized cause of vaginal symptoms in adult women

Conclusion&nbsp;&nbsp;Vaginal infection with GAS in adult women is a clearly defined entity and should be considered a diagnosis when more common causes of vaginitis have been ruled out. Content Type Journal ArticlePages 1-4DOI 10.1007/s00404-011-1861-6Authors Hans Verstraelen, Department of Obstetrics and Gynaecology, Faculty of Medicine and Health Sciences, Ghent University, De Pintelaan 185, B-9000 Ghent, BelgiumRita Verhelst, Department of Clinical Chemistry, Microbiology, and Immunology, Faculty of Medicine and Health Sciences, Ghent University, Ghent, BelgiumMario Vaneechoutte, Department of Clinical Chemistry, Microbiology, and Immunology, Faculty of Medicine and Health Sciences, Ghent University, Ghent, BelgiumMarleen Temmerman, Department of Obstetrics and Gynaecology,...

CLINDAMYCIN PHOSPHATEsolution [Perrigo New York Inc]

Updated Date: Feb 17, 2011 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

Infection of hamsters with the UK C. difficile ribotype 027 outbreak strain R20291.

Authors: Buckley AM, Spencer J, Candlish D, Irvine JJ, Douce GR Clostridium difficile is the main cause of antibiotic associated disease (AAD), a disease of high socio-economical importance that has recently been compounded by the global spread of the 027 (BI/NAP1/027) ribotype. C. difficile cases attributed to ribotype 027 strains have high recurrence rates (up to 36%) and increased disease severity. The hamster model of infection is widely accepted as an appropriate model for studying aspects of C. difficile host-pathogen interactions. Using this model we characterised the infection kinetics of the UK 2006 outbreak strain, R20291. Hamsters were orally given a dose of clindamycin, followed 5 days later with 10,000 C. difficile spores. 100% of hamsters succumbed to infection with a mea...<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>

Molecular typing and characterization of macrolide, lincosamide, and streptogramin resistance in Staphylococcus epidermidis strains isolated in a Mexican hospital.

Authors: Castro-Alarcón N, Ribas-Aparicio RM, Silva-Sánchez J, Calderón-Navarro A, Sánchez-Pérez A, Parra-Rojas I, Aparicio-Ozores G Staphylococcus epidermidis is a normal commensal of skin that has become a serious clinical problem, because of the combination of increased use of intravascular devices and an increasing number of hospitalized immunocompromised patients. In addition, there is a lack of information pertaining to resistance to macrolide, lincosamide and streptogramin type B (MLSB) in developing countries, including Mexico. The aim of this study was to investigate the incidence of resistance to MLSB antibiotics in isolates of S. epidermidis obtained in the General Hospital of Acapulco in Mexico. We tested susceptibility to erythromycin, clindamycin, and quinupristin-da...

Antimicrobial Susceptibility of Canine and Human Staphylococcus aureus Collected in Saskatoon, Canada

SummaryStaphylococcus aureus is one of the most common causes of infection in people and is increasingly recognized in dogs. The increasing prevalence of methicillin resistant S.‚??aureus (MRSA) is complicating the treatment of these infections. Panton Valentine leukocidin (PVL), a toxin involved in the pathogenesis of necrotic syndromes in people may be partially responsible for the rise of MRSA. Canine and human S.‚??aureus from the same geographic area are genetically similar, indicating a common population and likely transmission. The implications of increasing antimicrobial resistance complicated by interspecies transmission, necessitates including both dogs and humans in S.‚??aureus resistance surveillance studies. A collection of 126 S.‚??aureus isolates from people (n‚??=‚??99) and...

ACANYA (Clindamycin Phosphate And Benzoyl Peroxide) Gel [Coria Laboratories]

Updated Date: Feb 14, 2011 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

In vitro activity of nifuratel on vaginal bacteria: could it be a good candidate for the treatment of bacterial vaginosis?

In this study, antimicrobial activity of nifuratel was compared with the two currently used antibiotics, metronidazole and clindamycin, against G. vaginalis, A. vaginae and lactobacilli. Results suggest that nifuratel has a better spectrum of activity, being highly active against G. vaginalis and A. vaginae, without affecting lactobacilli. PMID: 21321147 [PubMed - as supplied by publisher] (Source: Antimicrobial Agents and Chemotherapy)

The synergism between OM-proteins and antimicrobials.

Authors: Veiga-Crespo P, Fust√© E, Vinuesa T, Vi√Īas M, Villa TG Antibiotic-resistant bacteria are becoming one of the most important problems in healthcare, because the number and the paucity of new effective antimicrobials. Since antibiotic-resistant bacteria will continue to increase, it is necessary to look for new alternative strategies to fight against them. It is generally accepted that Gram-negative bacteria are intrinsically less susceptible than Gram-positiveto antimicrobials. The main reason is that Gram-negative bacteria are surrounded by a permeability barrier known as outer membrane (OM). Hydrophilic solutes most often cross the OM through water-filled channels formed by a particular family of proteins known asporins. This work explores the possibility of using exogenous ...<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>

Temporal abscess after third molar extraction in the mandible

Discussion&nbsp;&nbsp;The retromaxillary and temporal infections are quite common after maxillary molar extractions but not after mandibular third molar, the spread mechanism of ascension must be involved with the virulence of microorganisms, but more studies are necessary to clarify this occurrence. Content Type Journal ArticlePages 1-4DOI 10.1007/s10006-011-0262-0Authors Patr√≠cio Jos√© de Oliveira Neto, Department of Oral Diagnosis, Oral and Maxillofacial Surgery Division, Piracicaba Dental School CP 52, State University of Campinas‚??UNICAMP, 13.414-903 Piracicaba, S√£o Paulo BrazilMaximiana Cristina de Souza Maliska, Department of Oral Diagnosis, Oral and Maxillofacial Surgery Division, Piracicaba Dental School CP 52, State University of Campinas‚??UNICAMP, 13.414-903 Pir...

CLINDAMYCIN HYDROCHLORIDEcapsule [Lake Erie Medical DBA Quality Care Products LLC]

Updated Date: Feb 11, 2011 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

Evoclin (Clindamycin Phosphate) - updated on RxList

Evoclin (Clindamycin Phosphate) drug description - FDA approved labeling for prescription drugs and medications at RxList (Source: RxList - New and Updated Drug Monographs)

Activity of moxifloxacin against intracellular community-acquired methicillin-resistant Staphylococcus aureus: comparison with clindamycin, linezolid and co-trimoxazole and attempt at defining an intracellular susceptibility breakpoint

Conclusions Moxifloxacin is active against both extracellular and intracellular CA-MRSA if the MIC is low, and is more effective than clindamycin, co-trimoxazole and linezolid. (Source: Journal of Antimicrobial Chemotherapy)<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>

Clindesse (Clindamycin Phosphate) - updated on RxList

Clindesse (Clindamycin Phosphate) drug description - FDA approved labeling for prescription drugs and medications at RxList (Source: RxList - New and Updated Drug Monographs)

Antimicrobial resistance in Campylobacter coli isolated from pigs in two provinces of China.

Authors: Qin SS, Wu CM, Wang Y, Jeon B, Shen ZQ, Wang Y, Zhang Q, Shen JZ The aim of this study was to determine the prevalence, antimicrobial resistance and molecular epidemiology of Campylobacter coli isolated from swine in China. A total of 190 C. coli isolates obtained from two slaughter houses and ten conventional pig farms in Shandong (SD, n=95) and Ningxia (NX, n=95) provinces were tested for their susceptibility to 14 antimicrobials. A high prevalence (&gt;95%) of ciprofloxacin and tetracycline-resistant strains was observed in both SD and NX. The erythromycin and clindamycin resistance rates of C. coli from NX (ERY: 54.7% CLI: 43.2%) were higher than those from SD (ERY: 37.9%, CLI: 35.8%). A significant difference (P&lt;0.05) was observed in erythromycin resistance rate, but n...

Invasive neonatal GBS infections from an area based surveillance study in Italy.

AbstractDuring an area based study, 75 GBS strains isolated both from early onset disease (EOD, 37 strains) and from late onset disease (LOD; 38 strains) were analyzed for serotype, PFGE and MLST profiles, protein markers and antibiotic resistance. Serotype III, possessing the rib gene, was the most frequent (54 strains, 72%) and responsible for 89.5% and 54% of LOD and EOD, respectively. Forty‚?źsix serotype III strains belonged to the same PFGE type and clonal complex 17, already described as an overrepresented clone in neonatal invasive GBS infections. Other serotypes were Ia (9.3%), II (6.7%), Ib (5.3%), V (5.3%) and IV (1.3%). Seventeen PFGE groups were identified comprising strains with related ST; conversely, strains displaying the same ST could belong to different PFGE groups. When...

MRSA otorrhea: A case series and review of the literature.

This study illustrates the importance of determining individual drug sensitivities for optimal treatment and maintaining current knowledge of the local MRSA strains. Empiric combination therapy of TMP/SMX with gentamicin is an effective first-line treatment for MRSA otorrhea. Regional differences in clindamycin sensitivities warrant clinical discretion. Fluoroquinolones should be avoided because of high rates of resistance unless culture sensitivity determines that they are appropriate. First-line agents for severe infections include combination therapy with vancomycin or linezolid. PMID: 21328227 [PubMed - in process] (Source: Ear, Nose and Throat Journal)

Antimicrobial susceptibility of Staphylococcus aureus and Staphylococcus pseudintermedius isolated from various animals.

This study characterized the antimicrobial susceptibility of 221 Staphylococcus aureus isolated from various species, and 60 canine Staphylococcus pseudintermedius isolated from 1986 through 2000 at the Western College of Veterinary Medicine (WCVM). Resistance of S. aureus was most common to penicillin (31%) and tetracycline (14%); resistance of S. pseudintermedius to penicillin was present in 8% and to tetracycline in 34% of isolates. Resistance to trimethoprim/sulfamethoxazole was only seen among S. pseudintermedius, and there was no resistance to amoxicillin/clavulanate, ampicillin/sulbactam, cephalothin, amikacin, gentamicin, enrofloxacin, chloramphenicol, or rifampin among any isolate. Inducible clindamycin resistance was found in both S. aureus and S. pseudintermedius, highlighting t...<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>

Invasive neonatal GBS infections from an area‚?źbased surveillance study in Italy

Clin Microbiol InfectAbstractDuring an area‚?źbased study, 75 group B streptococcus (GBS) strains isolated both from early‚?źonset disease (EOD, 37 strains) and from late‚?źonset disease (LOD, 38 strains) were analysed for serotype, pulsed field gel electrophoresis (PFGE) and multilocus sequence typing profiles, protein markers and antibiotic resistance. Serotype III, possessing the rib gene, was the most frequent (54 strains, 72%) and responsible for 89.5% and 54% of LOD and EOD, respectively. Forty‚?źsix serotype III strains belonged to the same PFGE type and clonal complex 17, already described as an over‚?źrepresented clone in neonatal invasive GBS infections. Other serotypes were Ia (9.3%), II (6.7%), Ib (5.3%), V (5.3%) and IV (1.3%). Seventeen PFGE groups were identified comprising ...

Mupirocin resistance in Staphylococcus aureus causing recurrent skin and soft tissue infections in children.

Authors: McNeil JC, Hulten KG, Kaplan SL, Mason EO Staphylococcus aureus resistance to mupirocin is often caused by acquisition of a novel isoleucyl-tRNA synthetase encoded on the plasmid gene, mupA. We tested S. aureus isolates from children at TCH with recurrent skin and soft tissue infections for mupirocin resistance and mupA. Of 136 isolates, 20 were resistant to mupirocin (14.7%). 15 isolates (11%) carried mupA and was more common in MSSA (21.4%) than MRSA (8.3%, p= 0.03). 7/20 mupirocin resistant isolates displayed clindamycin resistance. PMID: 21282426 [PubMed - as supplied by publisher] (Source: Antimicrobial Agents and Chemotherapy)

Med Sci Monit 2011; 17(2):BR48-53 &quot;Phenotypic and genotypic study of macrolide, lincosamide and streptogramin B (MLSB) resistance in clinical isolates of Staphylococcus aureus in Tehran, Iran&quot;

Conclusions: Due to the high prevalence of clindamycin resistance among S. aureus isolated from patients in Iran, we recommend clindamycin therapy only after proper antimicrobial susceptibility testing. (Source: Medical Science Monitor)

Prevalence and characteristics of methicillin-resistant coagulase-negative staphylococci from livestock, chicken carcasses, bulk tank milk, minced meat, and contact persons

Conclusions: A high prevalence of MR-CNS was found in livestock production. This is of concern in view of potential spread of mecA to S. aureus (MRSA). Multiresistant CNS strains might become an emerging problem for veterinary medicine. For species identification of MR-CNS isolated from different origins, MALDI-TOF MS proved to be a fast and reliable tool and is suitable for screening of large sample amounts. (Source: BMC Veterinary Research - Latest articles)

CLINDESSE (Clindamycin Phosphate) Cream [Ther-Rx Corporation]

Updated Date: Jan 25, 2011 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>

DUAC (Clindamycin Phosphate And Benzoyl Peroxide) Gel DUAC (Clindamycin Phosphate And Benzoyl Peroxide) Gel [Stiefel Laboratories Inc]

Updated Date: Jan 24, 2011 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

CLINDAMYCIN PHOSPHATEinjection, Solution [Physicians Total Care, Inc.]

Updated Date: Jan 21, 2011 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

A case of septicaemic anthrax in an intravenous drug user

Conclusions: Although systemic anthrax infection is rare, it should be considered when faced with severe cutaneous infection in IVDU patients. This case shows that patients with significant bacteraemia may present with no signs of haemodynamic compromise. Prompt recognition and treatment with high dose IV antimicrobial therapy increases the likelihood of survival. The use of simple wound therapy adjuncts such as NPWT can give excellent wound healing results. (Source: BMC Infectious Diseases)

Fusobacterium necrophorum endocarditis: Case report and review of the literature

Abstract: Fusobacterium necrophorum is a gram-negative anaerobic bacillus that can cause serious systemic infections typically in previously healthy young adults. Lemierre's syndrome, also known as post-anginal sepsis or necrobacillosis, is the infection most usually associated with F. necrophorum. However, F. necrophorum is also a very rare cause of anaerobic endocarditis. Mortality and rates of thromboembolism are high with F. necrophorum endocarditis. In this article, we describe a case of F. necrophorum native valve infective endocarditis. The patient was treated with penicillin plus clindamycin followed by penicillin alone for 6 weeks resulting in complete resolution of infection. (Source: Diagnostic Microbiology and Infectious Disease)

Hospital Pharmacists Scrambling Amid Vast Drug Shortages: Emergency Physicians Between Roc and a Hard Place

On the Web site of the American Society of Health System Pharmacists (ASHP), the list goes on for pages: atracurium, bumetanide, buprenorphine, clindamycin, cisatracurium, epinephrine, fentanyl, furosemide, lipid emulsion, lidocaine, metronidazole, naloxone, propofol, rocuronium, succinylcholine, sulfamethoxazole-trimethoprim, torsemide, vancomycin hydrochloride, vecuronium. They are all sterile injectable drugs that an emergency physician might use every day, and they and dozens of other drugs‚??more than 140 in late November‚??are on the list because they are either unavailable or in extremely short supply. There is a similar though less complete list, bearing 50 names in late November, on the Web site of the Food and Drug Administration (FDA). (Source: Annals of Emergency Medicine)<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>

CLINDACURE (Clindamycin Hydrochloride) Liquid [Vedco, Inc.]

Updated Date: Jan 18, 2011 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

[Necrotizing fasciitis: Study of 17 cases presenting a low mortality rate.]

CONCLUSION: Contrary to the data from the literature, this study presents a decrease of the mortality in necrotizing fasciitis with an early treatment and an adequate management. The precocity and the quality of surgical procedures as well as the presence of an underlying disease are determining factors for successful management of necrotizing fasciitis. PMID: 21236543 [PubMed - as supplied by publisher] (Source: Annales de Chirurgie Plastique et Esthetique)

Significance of methicillin‚??teicoplanin resistant Staphylococcus haemolyticus in bloodstream infections in patients of the Semmelweis University hospitals in Hungary

Abstract&nbsp;&nbsp;The purpose of this study was to quantify the impact of Staphylococcus haemolyticus in the epidemiology of the blood stream infection (BSI) and to characterize the rates and quantitative levels of resistance to antistaphylococcal drugs. During an eight-year period, 2967 BSIs of the patients hospitalized in different clinical departments of the Semmelweis University, Budapest, Hungary were analyzed. One hundred eighty-four were caused by S. haemolyticus, amounting to 6% of all infections. The antibacterial resistance of S. haemolyticus isolates was investigated by the broth microdilution method, vancomycin agar screen, population analysis profile and PCR for mecA, vanA and vanB genes detection. Epidemiological investigation was processed by determining phenotypic anti...

Characterization and Transfer of Antibiotic Resistance in Lactic Acid Bacteria from Fermented Food Products.

Authors: Nawaz M, Wang J, Zhou A, Ma C, Wu X, Moore JE, Cherie Millar B, Xu J The study provides phenotypic and molecular analyses of the antibiotic resistance in lactic acid bacteria (LAB) from fermented foods in Xi'an, China. LAB strains (n = 84) belonging to 16 species of Lactobacillus (n = 73), and Streptococcus thermophilus (n = 11) were isolated and identified by sequencing their 16S rRNA gene. All strains were susceptible to ampicillin, bacitracin, and cefsulodin, and intrinsically resistant to nalidixic acid, kanamycin, and vancomycin (except L. bulgaricus, L. acidophilus, and S. thermophilus, which were susceptible to vancomycin). Some strains had acquired resistance for penicillin (n = 2), erythromycin (n = 9), clindamycin (n = 5), and tetracycline (n = 14), whi...

Local treatment of acne.

We present recommendations for topical treatment options in mild to moderate acne vulgaris Material and methods. The article is based on a non-systematic literature search in PubMed and clinical experience. Results. Increased sebum production, abnormal proliferation of the sebaceous gland duct and propionibacterium acnes are all important for the development of acne. In comedonal acne, keratolytic treatment with topical retinoid is recommended. If pustules are present, such treatment should be combined with topical antibacterial treatment, i.e benzoyl peroxide or clindamycin. Interpretation. It is important to understand the pathophysiological mechanisms of acne in order to choose the most effective treatment. PMID: 21233886 [PubMed - as supplied by publisher] (Source: Tidsskrift for d...<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>

Characterization of SCCmec Types and Antibacterial Susceptibility Patterns of Methicillin-Resistant Staphylococcus aureus in Southern Iran.

Authors: Japoni A, Jamalidoust M, Farshad S, Ziyaeyan M, Alborzi A, Japoni S, Rafaatpour N A total of 156 methicillin-resistant Staphylococcus aureus (MRSA) isolates from patients hospitalized in southern Iran were tested for staphylococcal cassette chromosome mec (SCCmec) types and antibacterial susceptibility patterns between May 2008 and May 2009. Type III SCCmec was the most prevalent (116, 74.3%), followed by mec types A (147 bp only; 11, 7.1%), IVa (8, 5.1%), IVc (7, 4.5%), IVd and V (4, 2.6%), and II (1, 0.6%). Class A mec and type III ccr and mec complexes were also predominant. All isolates were found to be sensitive to vancomycin, teicoplanin, linezolid, quinupristin-dalfopristin, mupirocin, and fusidic acid. However, reduced sensitivity of these MRSA isolates to other antibi...

Veltin gel (clindamycin phosphate 1.2% and tretinoin 0.025%).

Authors: Abramovits W, Oquendo M, Gupta AK PMID: 21409962 [PubMed - in process] (Source: Skinmed)

CLINDESSE (Clindamycin Phosphate) Cream [Ther-Rx Corporation]

Updated Date: Dec 28, 2010 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

Antimicrobial susceptibility of clinically relevant Gram-positive anaerobic cocci, collected in a 3-year period in the Netherlands.

Authors: Veloo AC, Welling GW, Degener JE The susceptibility of 14 species of 115 Gram-positive anaerobic cocci (GPAC) was determined for 14 antibiotics. To assure correct identification, strains were genotypically identified by fluorescent in situ hybridisation and sequencing. Susceptibility differences (MIC50 and MIC90) for penicillin G, clindamycin, tigecycline, levofloxacin, amoxicillin-clavulanic acid, cefoxitin, ertapenem, meropenem, metronidazole, and doxycycline were found for the three clinically most relevant GPAC species; Finegoldia magna, Parvimonas micra, and Peptoniphilus harei. PMID: 21189338 [PubMed - as supplied by publisher] (Source: Antimicrobial Agents and Chemotherapy)

CLINDAMYCIN HYDROCHLORIDEcapsule [REMEDYREPACK INC. ]

Updated Date: Dec 22, 2010 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>

CLEOCIN (Clindamycin Phosphate) Suppository [Physicians Total Care, Inc.]

Updated Date: Dec 20, 2010 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

CLEOCIN (Clindamycin Palmitate Hydrochloride) Granule, For Solution [Physicians Total Care, Inc.]

Updated Date: Dec 20, 2010 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

Trimethoprim-Sulfamethoxazole or Clindamycin for Community-Associated MRSA (CA-MRSA) Skin Infections

Community-associated MRSA has emerged as the predominant cause of skin infections in the US. Which is the antibiotic treatment of choice: trimethoprim-sulfamethoxazole or clindamycin? Journal of the American Board of Family Medicine (Source: Medscape Today Headlines)

Efficacy and Safety of Moxifloxacin versus Clindamycin in the Treatment of Odontogenic Abscesses and Inflammatory Infiltrates: A Phase II, Double-Blind, Randomized Trial.

The objective of this prospective, randomized, double-blind, multicenter study was to compare the efficacy and safety of moxifloxacin and clindamycin in the medical treatment of patients with gingival inflammatory infiltrates and as an adjuvant therapy in patients with odontogenic abscesses requiring surgical treatment. Patients received either moxifloxacin 400 mg per os once daily or clindamycin 300 mg per os four times daily for 5 days consecutively. Primary efficacy endpoint was the percent reduction in patients' perceived pain on a visual analogue scale at day 2-3 from baseline. Primary analysis included 21 moxifloxacin- and 19 clindamycin-treated patients with infiltrates and 15 moxifloxacin- and 16 clindamycin-treated patients with abscesses. Mean pain reduction was 61.0% (SD, 46.9%)...

Identification of a Novel Keyhole Phenotype in Double-Disk Diffusion Assays of Clindamycin-Resistant Erythromycin-Sensitive Strains of Streptococcus agalactiae

Microbial Drug Resistance , Vol. 0, No. 0. (Source: Microbial Drug Resistance)<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>

CLINDAMYCIN HYDROCHLORIDEcapsule [TEVA Pharmaceuticals USA Inc]

Updated Date: Dec 16, 2010 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

Fecal lactoferrin and Clostridium spp. in stools of autistic children.

Authors: Martirosian G, Ekiel A, Aptekorz M, WiechuŇ?a B, Kazek B, Jankowska-Steifer E, J√≥Ňļwiak J, Moskalewski S Stools from autistic and healthy children were studied for fecal lactoferrin, Clostridium difficile toxins, Clostridium perfringens enterotoxin and cultured for Clostridium spp. Elevated level of FLA was demonstrated in 24.4% stools, all from boys (31.25%). No toxins were detected. Clostridium spp. was isolated with similar frequency from all samples. C. perfringens were isolated significantly often from the autistic stools, intermediate sensitive strains to penicillin 19%, to clindamycin 11.3%, and to metronidazole 7.5% were detected. Further studies on fecal microflora and inflammatory mediators, with larger groups of patients, are required in order to explain their role...

Distinctive patterns of macrolide‚??lincosamide‚??streptogramin resistance phenotypes and determinants amongst Staphylococcus aureus populations in Hong Kong

In this study, we determined the prevalence of MLS phenotypes and their resistance determinants amongst CA-MRSA isolates and compared them with meticillin-sensitive S. aureus (MSSA) and healthcare-associated (HA)-MRSA isolates from Hong Kong. (Source: International Journal of Antimicrobial Agents)

Plasma protein binding may reduce antimicrobial activity by preventing intra-bacterial uptake of antibiotics, for example clindamycin

Conclusions Reduction of the intracellular radioactive signal in the presence of serum proteins correlated both with the degree of protein binding and reduction of antimicrobial activity supporting the hypothesis of impairment of activity by PPB by reducing intra-bacterial antimicrobial concentrations. (Source: Journal of Antimicrobial Chemotherapy)

Duac Topical Gel (Clindamycin Benzoyl Peroxide) - updated on RxList

Duac Topical Gel (Clindamycin Benzoyl Peroxide) drug description - FDA approved labeling for prescription drugs and medications at RxList (Source: RxList - New and Updated Drug Monographs)<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>

Fusidic acid and clindamycin resistance in community-associated, methicillin-resistant Staphylococcus aureus infections in children of Central Greece

Conclusion: In areas with high rate of infections caused by multidrug-resistant CA-MRSA isolates, predominantly belonging to the European ST80 clone, fusidic acid and clindamycin should be used cautiously as empiric therapy in patients with suspected severe staphylococcal infections. (Source: BMC Infectious Diseases)

CLINDAMYCIN HYDROCHLORIDEcapsule [Rebel Distributors Corp]

Updated Date: Dec 10, 2010 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

Clindamycin + isotretinoin relieve erlotinib-induced rash

(Source: Reactions)

Clindamycin: First report of DRESS syndrome: case report

(Source: Reactions)

Tigecycline exhibits inhibitory activity against Clostridium difficile in the colon of mice and does not promote growth or toxin production.

Authors: Jump RL, Li Y, Pultz MJ, Kypriotakis G, Donskey CJ Tigecycline is a broad-spectrum glycylcycline antibiotic with potent in vitro activity against Clostridium difficile. We used a mouse model to test the hypothesis that tigecycline has a low propensity to promote colonization and toxin production by C. difficile due to inhibitory activity in the colon. Mice (5-8 per group) received subcutaneous tigecycline (low and high dose) alone or in combination with clindamycin for 6 days. Growth of and toxin production by 3 strains of C. difficile (tigecycline minimum inhibitory concentrations ‚?§0.012 őľg/mL) were measured in cecal contents collected 6 hours or 3 days after the final antibiotic dose. Antibiotic concentrations were measured using a bioassay and concentrations of total ana...<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>

DTB: What role for topical antibacterials in acne?

This article in the Drug and Therapeutics Bulletin (DTB) consider the place of topical antibacterials for acne, including the risk of bacterial resistance. The following topics are discussed: &nbsp; .&nbsp;Acne .&nbsp;Methods for grading acne severity .&nbsp;Management principles .&nbsp;Topical treatment options (non-antibacterial and antibacterial agents) .&nbsp;Efficacy of topical antibacterials as monotherapy .&nbsp;Efficacy of topical antibacterials in combination therapy (erythromycin plus benzoyl peroxide, clindamycin plus benzoyl peroxide, antibacterials with tretinoin) .&nbsp;Resistance to topical antibacterials .&nbsp;Guidelines &nbsp; The article concluded that topical antibacterials are well tolerated, effective treatment options for mild to moderate infla...

CLINDAGEL (Clindamycin Phosphate) Gel [Galderma Laboratories, L.P.]

Updated Date: Dec 1, 2010 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

Updated national IV monograph on Clindamycin

Source: Medusa Area: News An updated IV monograph on Clindamycin is now available from the NHS injectable medicines guide website (Medusa). Please see the link below for access (registration required). (Source: NeLM - News)

[Evaluation of the Performance of the MicroScan Pos Breakpoint Combo Panel Type 28 for Susceptibility Testing of Staphylococcus aureus: Low-range Minimum Inhibitory Concentration of Vancomycin, Cefoxitin Screening, and Inducible Clindamycin Resistance Detection.]

CONCLUSIONS: PBC28 can be appropriate susceptibility testing of S. aureus, including MRSA detection and ICD. However, the lower-range vancomycin MIC test was not reproducible enough to reliably differentiate MIC of 2 ¬Ķg/mL from MIC‚?§1 ¬Ķg/mL. PMID: 21157151 [PubMed - as supplied by publisher] (Source: The Korean Journal of Laboratory Medicine)

Distribution of genes encoding resistance to macrolides, lincosamides and streptogramins among clinical staphylococcal isolates in a Turkish university hospital.

This study investigated the prevalence of genes encoding resistance to macrolides, lincosamides and strep-togramins (MLS(B)) among staphylococci in a series of 301 erythromycin-resistant clinical isolates of Staphylococcus aureus and coagulase-negative staphylococci (CoNS). Erythromycin-resistance phenotypes were determined according to Clinical and Laboratory Standards Institute guidelines and specific resistance genes erm(A), erm(B), erm(C), msr(A) and msr(B) were identified using polymerase chain reaction. Two hundred of 301 (66.5%) erythromycin-resistant staphylococcal isolates exhibited resistance to MLS(B) antibiotics. Of these, 127 (63.5%) exhibited a cMLS(B) resistance phenotype (resistant to both erythromycin and clindamycin), whereas 73 (36.5%) expressed the iMLS(B) resistance ph...<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>

Treatment of skin and soft tissue infections in the Elderly: A review.

Conclusions: A search of the literature did not identify any prospective clinical trials on the treatment of SSTIs in the elderly; therefore, it is recommended to follow treatment based on the current IDSA guidelines. More research and publications are needed to establish proper selection of antimicrobial agents, treatment strategies, and duration of therapy of SSTIs in the elderly population. PMID: 21356502 [PubMed - in process] (Source: The American Journal of Geriatric Pharmacotherapy)

Distribution of erm genes and low prevalence of inducible resistance to clindamycin among staphylococci isolates.

Authors: Coutinho Vde L, Paiva RM, Reiter KC, de-Paris F, Barth AL, Machado AB Resistance to macrolides, lincosamides and streptogramins B (MLS B antibiotics) in staphylococci may be due to modification in ribosomal target methylase encoded by erm genes. The expression of MLS B resistance lead to three phenotypes, namely constitutive resistance (cMLS B), inducible resistance (iMLS B), and resistance only to macrolides and streptogramins B (MS B). The iMLS B resistance is the most difficult to detect in the clinical laboratory. PMID: 21340296 [PubMed - in process] (Source: Braz J Infect Dis)

Clindamycin: Dysgeusia: 12 case reports

(Source: Reactions)

CLINDAMYCIN HYDROCHLORIDEcapsule [Lannett Company, Inc.]

Updated Date: Nov 30, 2010 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

Antibiotic susceptibility of Propionibacterium acnes isolated from acne vulgaris in Korea

AbstractPropionibacterium acnes plays an important role in the development of acne, and inflammatory lesions are improved by antibiotics. Long‚?źterm use of antibiotics may result in development of resistant strains and treatment failure. The aim of the present study was to investigate the isolation rate of P.¬†acnes and to evaluate its antibiotic susceptibility to widely used antibiotics in acne in Korea. Among 46 patients, 31 P.¬†acnes strains were cultured. Isolated P.¬†acnes was measured for minimum inhibitory concentration (MIC) of tetracycline, doxycycline, minocycline, erythromycin and clindamycin using an Epsilometer test. Age, disease duration and previous history of antibiotic therapy for acne were compared in relation to the MIC. The mean MIC of tetracycline, minocyclines, doxyc...<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>

Community-associated Methicillin-resistant Staphylococcus aureus Skin Infections in the Tropics

Skin and soft tissue infections (SSTI) caused by Staphylococcus aureus are very common, particularly in children, in tropical regions. The proportion of S aureus SSTI caused by community-associated methicillin-resistant S aureus (CA-MRSA) varies according to region, but is up to 25% in some areas. There are diverse CA-MRSA clones, including several that harbor Panton-Valentine leukocidin. Key predisposing factors for staphylococcal infections are scabies infestation, overcrowding, poor hygiene, and inadequate water supplies. In the setting of a community outbreak of staphylococcal SSTI, interventions intended to improve personal and community hygiene are likely to be the most practical, effective, and achievable. Options for oral treatment of clinical infections caused by CA-MRSA include c...

CLINDAMYCIN PHOSPHATEsolution [Rebel Distributors Corp]

Updated Date: Nov 23, 2010 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

Assemblage of drug release modules: Effect of module shape and position in the assembled systems on floating behavior and release rate.

Authors: Hascicek C, Rossi A, Colombo P, Massimo G, Strusi OL, Colombo G The aim of this work was to study the clindamycin release kinetics from floating delivery systems consisting of two modules assembled in void configuration, according to the modified release technology platform known as Dome Matrix¬ģ. Two modules differently shaped, i.e., female and male, formulated as swellable matrices and containing clindamycin, were assembled by friction interlocking. Then, by stacking additional female modules without drug on the assembled two-module floating system, modulation of clindamycin release rate and kinetics was attained. The additional modules stacked on the assembled system acted as a transient barrier to clindamycin release from the void configuration. Inertness, dissolution/eros...

Antimicrobial characterisation of solithromycin (CEM-101), a novel fluoroketolide: activity against staphylococci and enterococci

In this study, solithromycin and comparator antimicrobials were tested against a contemporary collection of Staphylococcus aureus, coagulase-negative staphylococci, Enterococcus faecalis, Enterococcus faecium and other Enterococcus spp. collected in the SENTRY Antimicrobial Surveillance Program. Solithromycin was active against S. aureus [minimum inhibitory concentration for 50% of the organisms (MIC50)=0.12őľg/mL] and was two-fold more active than telithromycin (MIC50=0.25őľg/mL). Solithromycin was more potent against meticillin (oxacillin)-susceptible S. aureus [MIC50=0.06őľg/mL and MIC for 90% of the organisms (MIC90)=0.12őľg/mL) compared with meticillin (oxacillin)-resistant S. aureus (MIC50=0.12őľg/mL and MIC90>16őľg/mL). Solithromycin activity was reduced amongst heterogeneous vancom...

Characteristics of Staphylococcus aureus colonization in patients with atopic dermatitis in Sri Lanka

Conclusions.‚?? SA colonization rates were significantly associated with increasing age and severity of AD, and particularly with duration of lesions. Patients with severe disease were also more likely to be colonized with SA strains resistant to conventional antibiotics. (Source: Clinical And Experimental Dermatology)<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>

CLINDAMYCIN HYDROCHLORIDEcapsule [Lake Erie Medical DBA Quality Care Products LLC]

Updated Date: Nov 10, 2010 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

CLINDAMYCIN PHOSPHATEsolution [Perrigo New York Inc]

Updated Date: Nov 9, 2010 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

In vitro susceptibility of Actinobaculum schaalii to 12 antimicrobial agents and molecular analysis of fluoroquinolone resistance

Conclusions When an infection caused by A. schaalii is suspected, there is a risk of clinical failure by treating with ciprofloxacin or co-trimoxazole, and &beta;-lactams should be preferred. In addition, acquired resistance to fluoroquinolones more active against Gram-positive bacteria is possible. (Source: Journal of Antimicrobial Chemotherapy)

The dissemination of ST80-SCCmec-IV community-associated methicillin resistant Staphylococcus aureus clone in Kuwait hospitals.

Conclusions: ST80-SCCmecIV was the most common CA-MRSA clone in Kuwait hospitals presenting new challenges for infection control. (Source: Annals of Clinical Microbiology and Antimicrobials)<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>

CLINDAMYCIN PHOSPHATEsolution [VersaPharm Incorporated]

Updated Date: Nov 3, 2010 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

Genome scanning of Amazonian Plasmodium falciparum shows subtelomeric instability and clindamycin-resistant parasites [RESEARCH]

Here, we fully characterize the genomes of 14 Plasmodium falciparum patient isolates taken recently from the Iquitos region using genome scanning, a microarray-based technique that delineates the majority of single-base changes, indels, and copy number variants distinguishing the coding regions of two clones. We show that the parasite population in the Peruvian Amazon bears a limited number of genotypes and low recombination frequencies. Despite the essentially clonal nature of some isolates, we see high frequencies of mutations in subtelomeric highly variable genes and internal var genes, indicating mutations arising during self-mating or mitotic replication. The data also reveal that one or two meioses separate different isolates, showing that P. falciparum clones isolated from different...

In Vitro Activity of Ceftaroline Against a Broad Spectrum of Recent Clinical Anaerobic Isolates.

Authors: Snydman DR, Jacobus NV, McDermott LA The in vitro activity of ceftaroline was compared with that of ceftriaxone, clindamycin, imipenem, metronidazole, moxifloxacin, tigecycline, and vancomycin against 514 clinical anaerobic isolates using Clinical and Laboratory Standards Institute (CLSI) standard methodology. Ceftaroline demonstrated good to excellent activity against gram-positive anaerobic pathogens and limited activity against gram-negative pathogens in particular Bacteroides fragilis group isolates. PMID: 21041506 [PubMed - as supplied by publisher] (Source: Antimicrobial Agents and Chemotherapy)

Benzoyl peroxide: enhancing antibiotic efficacy in acne management.

Authors: Dutil M Benzoyl peroxide is one of the most widely used topical agents for acne. It has potent antibacterial and mild anti-inflammatory and comedolytic effects. To treat mild to moderate acne, it can be used alone or in combination with topical antibiotics and topical retinoids. The combination of benzoyl peroxide with either erythromycin or clindamycin is synergistic and well-tolerated. In more severe acne, when oral antibiotics are required, benzoyl peroxide can contribute to suppressing the emergence of resistant strains of Propionibacterium acnes. PMID: 21076800 [PubMed - in process] (Source: Skin Therapy Letter)

Retrospective cohort study of hospitalized adults treated with vancomycin or clindamycin for methicillin-resistant Staphylococcus aureus skin infections.

Conclusions: In a single institution with a low rate of clindamycin resistance, there were no significant differences between vancomycin and clindamycin for the treatment of these hospitalized patients with MRSA skin infections, on the basis of clinical outcomes data. This finding warrants further investigation in a randomized controlled trial. PMID: 21118737 [PubMed - in process] (Source: Clinical Therapeutics)<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>

Clinical characteristics of children with group A streptococcal toxic shock syndrome admitted to pediatric intensive care units

Conclusions: STSS is a very severe condition secondary to invasive GAS infection. It can occur at any age, but especially in young children. Due to the lack of specific symptoms and signs and its very rapid progression to shock and organ dysfunction, pediatricians and emergency physicians must be aware of this possibility and immediately initiate aggressive treatment when suspected. Content Type Journal ArticleDOI 10.1007/s00431-010-1337-xAuthors Antonio Rodr√≠guez-Nu√Īez, Pediatric Emergency and Critical Care Division, Hospital Cl√≠nico Universitario de Santiago de Compostela, Santiago de Compostela, SpainSilvia Dosil-Gallardo, Pediatric Emergency and Critical Care Division, Hospital Cl√≠nico Universitario de Santiago de Compostela, Santiago de Compostela, SpainIolanda Jordan, Pe...

Antimicrobial Resistance of Campylobacter Isolated from Retail Meat in the United States: 2002-2007.

The objectives of this study were to determine the prevalence, antimicrobial susceptibility, and genetic relatedness of Campylobacter spp. recovered from the National Antimicrobial Resistance Monitoring System (NARMS) retail meat program. Retail meat samples (N= 24,566) from 10 U.S. states collected during 2002-2007 were analyzed, consisting of 6,138 chicken breast, 6,109 ground turkey, 6,171 ground beef and 6,148 pork chops. A total of 2,258 C. jejuni, 925 C. coli and 7 C. lari were identified. Chicken breast showed the highest contamination rate (49.9%), followed by ground turkey (1.6%); whereas both pork chops and ground beef had &lt; 0.5% contamination. The most common resistance was to doxycycline/tetracycline (46.6%), followed by nalidixic acid (18.5%), ciprofloxacin (17.4%), azithro...

CLINDAMYCIN PHOSPHATEinjection, Solution [Physicians Total Care, Inc.]

Updated Date: Oct 21, 2010 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

CLINDAMYCIN PHOSPHATEcream [Physicians Total Care, Inc.]

Updated Date: Oct 21, 2010 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

CLINDAMYCIN PHOSPHATElotion CLINDAMYCIN PHOSPHATEsolution CLINDAMYCIN PHOSPHATEgel [Physicians Total Care, Inc.]

Updated Date: Oct 21, 2010 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>

Ludwig's Angina

A previously healthy 33-year-old man, with a history of type 1 diabetes mellitus, underwent left lower molar extraction. Two days later, he presented to the emergency department with swelling in the left submandibular area and was subsequently treated with meperidine, codeine, and penicillin G. Two days later, after an unsuccessful resolution, he returned with bilateral submandibular swelling and difficulty swallowing and breathing. Vital signs were as follows: heart rate 140 beats/min, respiratory rate 28 beats/min, blood pressure 220/120 mm Hg, and temperature 39¬įC. After admission, he was taken to the operating room for an emergency tracheostomy and a drainage procedure. Antibiotic therapy was continued with penicillin G and clindamycin, and he made an uneventful recovery. (Source: The...

Role of Efflux in Macrolide Resistance in Beta Haemolytic Streptococci Groups A, B, C & G in St. James' Hospital, Dublin.

In conclusion, erythromycin resistance rates in BHS have increased over the past number of years in St. James' Hospital. This study highlights the role of efflux in macrolide resistance in BHS, which may have an impact on our antibiotic choice in clinical practice. The current study provides a baseline from which future trends in MLS(B) resistance can be monitored. PMID: 20965921 [PubMed - as supplied by publisher] (Source: Journal of Medical Microbiology)

DNA chip-assisted diagnosis of a previously unknown etiology of intermediate uveitis- Toxoplasma gondii

We report the use of DNA chip technology in the identification of Toxoplasma gondii as the etiological agent in two patients with recurrent intermediate uveitis (IU). Both patients had recurrent episodes of vitritis (with no focal retinochoroidal lesion) over varying time intervals and were diagnosed to have IU. The tuberculin test was negative in both. Blood counts, erythrocyte sedimentation rate, and serum angiotensin convertase enzyme levels were normal. In both cases, the vitreous fluid tested positive for the T. gondii DNA sequence by using a uveitis DNA chip (XCyton Pvt. Ltd., Bangalore, India). It contained complimentary sequences to &quot;signature genes&quot; of T. gondii, Mycobacterium tuberculosis, M. chelonae, and M. fortuitum. The enzyme-linked immunosorbent assay (ELISA) dete...

Different antibiotic treatments for group A streptococcal pharyngitis.

CONCLUSIONS: Evidence is insufficient for clinically meaningful differences between antibiotics for GABHS tonsillopharyngitis. Limited evidence in adults suggests cephalosporins are more effective than penicillin for relapse, but the NNTB is high. Limited evidence in children suggests carbacephem is more effective for symptom resolution. Data on complications are too scarce to draw conclusions. Based on these results and considering the low cost and absence of resistance, penicillin can still be recommended as first choice. PMID: 20927734 [PubMed - in process] (Source: Cochrane Database of Systematic Reviews)

DNA chip-assisted diagnosis of a previously unknown etiology of intermediate uveitis- Toxoplasma gondii

We report the use of DNA chip technology in the identification of Toxoplasma gondii as the etiological agent in two patients with recurrent intermediate uveitis (IU). Both patients had recurrent episodes of vitritis (with no focal retinochoroidal lesion) over varying time intervals and were diagnosed to have IU. The tuberculin test was negative in both. Blood counts, erythrocyte sedimentation rate, and serum angiotensin convertase enzyme levels were normal. In both cases, the vitreous fluid tested positive for the T. gondii DNA sequence by using a uveitis DNA chip (XCyton Pvt. Ltd., Bangalore, India). It contained complimentary sequences to &quot;signature genes&quot; of T. gondii, Mycobacterium tuberculosis, M. chelonae, and M. fortuitum. The enzyme-linked immunosorbent assay (ELISA) dete...<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>

Protective effect of rifampicin and clindamycin impregnated devices against Staphylococcus spp. infection after cerebrospinal fluid diversion procedures

Conclusions: Antibiotic-impregnated catheters are a safe and helpful tool to reduce CSF shunting device-related infections. (Source: BioMed Central)

Increasing Threat of Community-Acquired Methicillin-Resistant Staphylococcus aureus.

CONCLUSION:: Continued emergence of MRSA in the community is a public-health problem that demands increased vigilance in the diagnosis and management of suspected and confirmed staphylococcal infections. PMID: 20944499 [PubMed - as supplied by publisher] (Source: The American Journal of the Medical Sciences)

Acquired Toxoplasmosis After Orthotopic Heart Transplantation in a Sulfonamide-Allergic Patient

We report the case of a young adult with a history of an allergic reaction to a sulfonamide antibiotic who developed toxoplasmosis after his second orthotopic heart transplant. As a result of this drug allergy, the patient did not receive prophylaxis with trimethoprim and sulfamethoxazole. He was successfully treated with clindamycin, pyrimethamine, and folic acid. Content Type Journal ArticleDOI 10.1007/s00246-010-9812-8Authors Aura Sanchez Mejia, Department of Pediatrics, Indiana University School of Medicine, Indianapolis, IN USAMark DeBrunner, Division of Pediatric Cardiology, Department of Pediatrics, Indiana University School of Medicine, Indianapolis, IN USAElaine Cox, Department of Pediatrics, Ryan White Center for Pediatric Infectious Diseases, Indiana University School o...

German multicentre survey of the antibiotic susceptibility of Bacteroides fragilis group and Prevotella species isolated from intra-abdominal infections: results from the PRISMA study

Conclusions Resistance among Bacteroides spp. involved in IAIs to antimicrobials with known activity against anaerobes does occur and the resistance rate observed for the carbapenems is a cause of concern. These data emphasize the need not only for periodic monitoring of the susceptibility of anaerobic pathogens to guide empirical treatment but also for species identification and susceptibility testing in selected patients with severe infections involving anaerobic bacteria. (Source: Journal of Antimicrobial Chemotherapy)

Structures of the Escherichia coli ribosome with antibiotics bound near the peptidyl transferase center explain spectra of drug action [Biophysics_And_Computational_Biology]

Differences between the structures of bacterial, archaeal, and eukaryotic ribosomes account for the selective action of antibiotics. Even minor variations in the structure of ribosomes of different bacterial species may lead to idiosyncratic, species-specific interactions of the drugs with their targets. Although crystallographic structures of antibiotics bound to the peptidyl transferase center or the exit tunnel of archaeal (Haloarcula marismortui) and bacterial (Deinococcus radiodurans) large ribosomal subunits have been reported, it remains unclear whether the interactions of antibiotics with these ribosomes accurately reflect those with the ribosomes of pathogenic bacteria. Here we report X-ray crystal structures of the Escherichia coli ribosome in complexes with clinically important ...<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>

Clindamycin/tacrolimus interaction: First report of an interaction, leading to decreased tacrolimus concentration: case report

(Source: Reactions)

CLINDAMYCIN PALMITATE HYDROCHLORIDEgranule, For Solution [Paddock Laboratories, Inc.]

Updated Date: Oct 4, 2010 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

CLINDAMYCIN HYDROCHLORIDEcapsule [Physicians Total Care, Inc.]

Updated Date: Oct 4, 2010 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

Hyperbaric oxygen therapy in a patient with autosomal dominant polycystic kidney disease with a perinephritic abscess

Abstract&nbsp;&nbsp;A 68-year-old female in hemodialysis due to autosomal dominant polycystic kidney disease underwent resection of cysts in her right kidney via a laparoscopic approach due to abdominal pain. Three weeks after surgery, she was admitted with sepsis. A CT scan showed a large abscess around the right kidney. Percutaneous drainage of abscess was performed. The pus smear showed Gram-positive cocci and the culture contained methicillin-resistant Staphylococcus aureus. Ciprofloxacin, clindamycin and vancomycin were given. In the 3&nbsp;weeks following admission, she remained febrile and septic and showed a progressive deterioration in her general condition, along with malnutrition and persistent drainage of purulent material from her right flank. The antibiotic therapy was c...

Empiric Outpatient Therapy with Trimethoprim-Sulfamethoxazole, Cephalexin, or Clindamycin for Cellulitis

Abstract: Background: Limited data exist on optimal empiric oral antibiotic treatment for outpatients with cellulitis in areas with a high prevalence of community-associated methicillin-resistant Staphylococcus aureus (MRSA) infections.Methods: We conducted a 3-year retrospective cohort study of outpatients with cellulitis empirically treated at a teaching clinic of a tertiary-care medical center in Hawaii. Patients who received more than 1 oral antibiotic, were hospitalized, or had no follow-up information were excluded. Treatment success rates for empiric therapy were compared among commonly prescribed antibiotics in our clinic: cephalexin, trimethoprim-sulfamethoxazole, and clindamycin. Risk factors for treatment failure were evaluated using multivariate logistic regression analysis.Res...<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>

Investigation of Toxin Gene Diversity, Molecular Epidemiology, and Antimicrobial Resistance of Clostridium difficile Isolated from 12 Hospitals in South Korea.

CONCLUSIONS: This is the first nationwide study on the toxin status, including PCR ribotyping and antimicrobial resistance, of C. difficile isolates in Korea. The prevalence of A-B+ strains was 25.7%, much higher than that reported from other countries. Binary toxin-producing strains accounted for 7.1% of all strains, which was not rare in Korea. The most prevalent ribotype was ribotype 017, and all A-B+ strains showed this pattern. We did not isolate strains with decreased susceptibility to metronidazole or vancomycin. PMID: 20890081 [PubMed - in process] (Source: The Korean Journal of Laboratory Medicine)

Decline in Erythromycin Resistance in Group A Streptococci from Acute Pharyngitis due to Changes in the emm Genotypes Rather Than Restriction of Antibiotic Use.

CONCLUSIONS: The erythromycin resistance rate of GAS isolated from children with acute pharyngitis was significantly lower in 2009 (4.6%) than in 2002 (44.8%). We observed a remarkable change in the distribution of emm genotypes during the 7-yr period. The significant decline in erythromycin resistance in 2009 might be associated with a prominent decrease in the resistant genotype emm12 (3.4% in 2009 vs. 28.0% in 2002) rather than restriction of macrolide use. PMID: 20890080 [PubMed - in process] (Source: The Korean Journal of Laboratory Medicine)

An outbreak case of Clostridium difficile-associated diarrhea among elderly inpatients of an intensive care unit of a tertiary hospital in Rio de Janeiro, Brazil

Abstract: The aim of this study was to investigate Clostridium difficile-associated diarrhea (CDAD) in an intensive care unit (ICU) of a tertiary hospital in Rio de Janeiro, Brazil, and to characterize epidemiologically C. difficile strains obtained from an outbreak of CDAD. Within almost a 4-year surveillance period, CDAD incidence was determined for the first time in Brazil, and a 3-fold increase was observed in the average rate of CDAD, featuring an outbreak. About 80% of the patients were over 65 years. The main antibiotic that could be probably associated to CDAD was piperacillin/tazobactam. Four toxigenic strains were isolated, 3 from stools and 1 from environmental samples. They were all resistant to clindamycin and fluoroquinolones. Fingerprinting analysis revealed their distributi...

Antibiotic susceptibility of members of the Lactobacillus acidophilus group using broth microdilution and molecular identification of their resistance determinants.

Authors: Mayrhofer S, van Hoek AH, Mair C, Huys G, Aarts HJ, Kneifel W, Domig KJ The range of antibiotic susceptibility to 13 antibiotics in 101 strains of the Lactobacillus acidophilus group was examined using the lactic acid bacteria susceptibility test medium (LSM) and broth microdilution. Additionally, microarray analysis and PCR were applied to identify resistance genes responsible for the displayed resistant phenotypes in a selection of strains. In general, narrow as well as broad unimodal and bimodal MIC distributions were observed for the Lactobacillus acidophilus group and the tested antimicrobial agents. Atypically resistant strains could be determined by visual inspection of the obtained MIC ranges for ampicillin, chloramphenicol, clindamycin, erythromycin, quinupristin/dalf...

Trench mouth

A 21-year-old male Marine presented with a three-day history of oral pain. The previous week he had been involved in predeployment field exercises and experienced flu-like symptoms. The patient was a nonsmoker, nondrinker, was on no medications, and had no significant medical or surgical history. Physical examination of the oral cavity showed acute gingivitis and acute inflammation, necrosis, and pseudomembrane formation of mucosal surfaces, including the lips, buccal, palate, and tongue (). The patient was treated with a 10-day course of oral clindamycin, Motrin (McNeil-PPC, Fort Washington, PA) for pain, oral rinses with chlorhexidine (Periogard; Colgate-Palmolive Company, New York, NY), and immediate dental consultation. The patient responded well to treatment and was back to full duty ...<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>

emm typing, antibiotic resistance and PFGE analysis of Streptococcus pyogenes in Lebanon.

Authors: Bahnan W, Hashwa F, Araj G, Tokajian S One hundred and three Streptococcus pyogenes isolates recovered mainly from strep throat infections from Lebanon were characterized by emm and Pulse Field Gel Eletcrophoresis (PFGE) typing. Thirty three emm types and subtypes were detected among the isolates. The PFGE was more discriminatory as a typing method. The prevalent emm types were emm1 (12.6%), emm22 (8.7%), emm28 (7.7%), emm88 (7.7%) and emm4 (6.8%) and all isolates were susceptible to vancomycin and penicillin G. Ten percent of the isolates were resistant to erythromycin and three percent resistant to erythromycin and clindamycin showing the MLSb phenotype. The emm sequences and PFGE pattern database that were developed in this study will serve as a basis for information for th...

clindamycin - oral, Cleocin

Title: clindamycin - oral, CleocinCategory: MedicationsCreated: 3/2/2005Last Editorial Review: 9/22/2010 (Source: MedicineNet Medications General)

CLINDAMYCIN PALMITATE HYDROCHLORIDEsolution [Greenstone LLC]

Updated Date: Sep 21, 2010 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

Partial rupture of the quadriceps muscle in a child

Conclusions: Multiple intramuscular injections may contribute to damage muscles and make prone to tears with muscle contractions. Doctors and nurses must be cautious to inject from different parts of both thighs. (Source: BioMed Central)<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>

Severe septic-shock like reaction to co-trimoxazole in an HIV-positive man

Adverse drug reactions occur at a greater frequency in HIV-infected individuals. A 38-year-old Eritrean man was treated with outpatient co-trimoxazole for confirmed Pneumocystis jirovecii pneumonia, but was switched to clindamycin and primaquine due to nausea and vomiting. Following development of methaemaglobinaemia, he was recommenced on prophylactic co-trimoxazole. He was later found moribund with features resembling septic shock and required invasive respiratory support. The diagnosis of a rare, but severe reaction to co-trimoxazole did not become apparent until he was rechallenged with prophylactic co-trimoxazole after recovery from his initial severe reaction. In an era of polypharmacy and an increasing availability of novel drugs, this case is a timely reminder to clinicians of the ...

Antimicrobial susceptibility and heteroresistance in Chinese Clostridium difficile strains.

Authors: Huang H, Weintraub A, Fang H, Wu S, Zhang Y, Nord CE One hundred and ten toxigenic Clostridiumdifficile isolates collected between December 2008 and May 2009 at Fudan University Hospital Huashan were analyzed for their antibiotic susceptibility patterns and resistance molecular basis. The heteroresistance to metronidazole in fresh isolates were detected as well. Sixteen different PCR ribotypes were identified with a dominant clone 017 accounting for 37.3% of the isolates, followed by 001 and H. Ribotype 027 was not found but one isolate belonged to ribotype 078. All the isolates were susceptible to vancomycin and piperacillin/tazobactam. Seventy-eight fresh isolates were tested for heteroresistance to metronidazole, 18 (23.1%) of them were found to be positive. Resistance to m...

Drug Rash with Eosinophilia and Systemic Symptoms Syndrome Associated with Clindamycin

We describe the first case of Drug Rash with Eosinophilia and Systemic Symptoms syndrome caused by clindamycin administration. (Source: The American Journal of Medicine)

CLINDAMYCIN PALMITATE HYDROCHLORIDEsolution [Greenstone LLC]

Updated Date: Sep 13, 2010 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

The increased risk of community‚?źacquired methicillin‚?źresistant Staphylococcus aureus neck abscesses in young children

Conclusions:Children younger than 16 months and/or with lateral neck abscesses are at a significantly increased risk of having an SA infection, the majority being MRSA. Laryngoscope, 2010 (Source: The Laryngoscope)<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>

Changing microbiological profile of pathogenic bacteria in diabetic foot infections: time for a rethink on which empirical therapy to choose?

Conclusions/interpretation&nbsp;&nbsp;Unlike in the West, in India Gram-negative bacteria were found to have always been dominant in the wounds of patients with diabetic foot infections. Infection with polymicrobial multidrug-resistant Gram-negative bacilli is common. The policy of empirical antimicrobial therapy at tertiary care needs to be changed. Content Type Journal ArticleDOI 10.1007/s00125-010-1893-7Authors P. Ramakant, Department of Endocrine Surgery, Sanjay Gandhi Post Graduate Institute of Medical Sciences, Raebarelly Road, Lucknow, 226014 Uttar Pradesh IndiaA. K. Verma, Department of Endocrine Surgery, Sanjay Gandhi Post Graduate Institute of Medical Sciences, Raebarelly Road, Lucknow, 226014 Uttar Pradesh IndiaR. Misra, Department of Microbiology, Sanjay Gandhi Pos...

A case of progressive macular hypomelanosis treated with 1% topical clindamycin lotion and narrow‚?źband ultraviolet B

(Source: Photodermatology, Photoimmunology and Photomedicine)

CLINDAMYCIN HYDROCHLORIDEcapsule [TEVA Pharmaceuticals USA Inc]

Updated Date: Sep 10, 2010 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

Genome-scanning of Amazonian Plasmodium falciparum shows subtelomeric instability and clindamycin-resistant parasites [RESEARCH]

Here, we fully characterize the genomes of 14 Plasmodium falciparum patient isolates taken recently from the Iquitos region using genome scanning, a microarray-based technique that delineates the majority of single-base changes, indels, and copy number variants distinguishing the coding regions of two clones. We show that the parasite population in the Peruvian Amazon bears a limited number of genotypes and low recombination frequencies. Despite the essentially clonal nature of some isolates, we see high frequencies of mutations in subtelomeric highly variable genes and internal var genes, indicating mutations arising during self-mating or mitotic replication. The data also reveal that one or two meioses separate different isolates, showing that P. falciparum clones isolated from different...

Clindamycin: Acute oedema of the larynx: 2 case reports

(Source: Reactions)<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>

CLINDAMYCIN HYDROCHLORIDEcapsule [Watson Laboratories, Inc.]

Updated Date: Sep 7, 2010 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

Antimicrobial susceptibility and resistance determinants of Clostridium butyricum isolates from preterm infants

This study reports the antibiotic susceptibility and genetic resistance determinants of 39 Clostridium butyricum strains isolated from the faeces of preterm infants as well as one reference strain. Results showed that all the strains were susceptible to cefoxitin, imipenem, vancomycin, tigecycline, metronidazole, chloramphenicol and linezolid. Resistance was observed to clindamycin (100%), penicillin G, amoxicillin and piperacillin (15%), tetracycline (7.5%) and erythromycin (5%). Investigation of the genetic basis of the observed resistance phenotypes showed that resistance to penicillin was due to ő≤-lactamase activity and that resistance to tetracycline involved tet(O) or tet(O/32/O) homologue genes. Clindamycin and erythromycin resistance may involve another genetic determinant, differ...

Clinical Spectrum of Desquamative Inflammatory Vaginitis

Abstract&nbsp;&nbsp;Desquamative inflammatory vaginitis (DIV) is a rare chronic clinical syndrome of unknown etiology characterized by profuse purulent vaginal discharge, diffuse exudative vaginitis, epithelial cell exfoliation, and pain. A diagnosis of DIV is often missed by even experienced practitioners owing to its rarity and its clinical and laboratory presentation similar to other inflammatory vulvovaginal disorders. Although DIV is difficult to treat and often requires long-term therapy for maintenance, successful therapy has been reported with topical steroids and clindamycin. Content Type Journal ArticleDOI 10.1007/s11908-010-0135-yAuthors Colleen Kennedy Stockdale, Department of Obstetrics and Gynecology, University of Iowa, 200 Hawkins Drive, Iowa City, IA 52242, USA ...

Keloid formation occurring in the distribution of a congenital vascular malformation.

Authors: Mandrell J, Youker S, Allen EJ, Hurley MY, Obadiah J A 35-year-old African American man presented with complaints of malodorous drainage from hypertrophic lesions on his occipital scalp (Figure 1, inset). The patient had no family history of keloid formation and no other keloids on his body. The hypertrophic mass on his scalp had been present for 10 years and had not been a result of any type of mechanical, surgical, or laser treatment. It corresponded to the distribution of a large vascular malformation over the occiput (Figure 1). The vascular malformation extended from the occipital scalp to the right parietal scalp, the right side of the face, neck, upper chest, and right arm, with varicosities and hypertrophy of the right upper extremity (Figure 2). The vascular malformat...

This Issue At A Glance

In a retrospective medical record review of 12 patients with posterior pole (zone 1) toxoplasmic retinochoroiditis (TRC), Lasave et al (p. 1831) have found that intravitreal clindamycin and dexamethasone is associated with resolution of the condition. The patients were placed on the medication due to an intolerance to oral medication, contraindication to oral medication due to pregnancy, or a lack of response despite oral antimicrobial treatment. The patients included in the study were treated weekly with intravitreal injections of clindamycin (1.5 mg/0.1 ml) and dexamethasone (400 őľg/0.1 ml), with an average of 3.6 injections. (The pregnant patients were treated every 4 weeks). The treatment resolved inflammation and in most cases was associated with improvement of visual acuity and cent...<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>

News From the FDA

The Food and Drug Administration has approved Veltin, gel containing clindamycin phosphate and tretinoin, for the topical treatment of acne vulgaris in patients aged 12 years and older (Source: Family Practice News)

Nosocomial blood stream infections in a neonatal intensive care unit in Ankara, Turkey.

In conclusion, nosocomial sepsis still has a high mortality rate. Gram-negative bacteria were the most commonly isolated microorganisms with Klebsiella spp. being dominant. All gram-negative species were resistant to ampicillin, and all gram-positive bacteria were resistant to penicillin. No glycopeptide or carbapenem resistance was found in gram-positive bacteria. In gram-negative bacteria, low amikacin and high gentamicin and cephalosporin resistances were found. No carbapenem resistance was found except for P. aeruginosa. Restricted and alternate antibiotic usage policies seem important for the resistance problem. PMID: 21434530 [PubMed - in process] (Source: The Turkish Journal of Pediatrics)

A fatal Mycobacterium chelonae infection in an immunosuppressed patient with systemic lupus erythematosus and concomitant Fahr‚??s syndrome

We present a case of systemic Mycobacterium chelonae infection in an immunosuppressed patient with systemic lupus erythematosus (SLE), idiopathic hypoparathyroidism, and hypothyroidism. The patient was treated for 3 months for skin infection with clarithromycin monotherapy. Since her condition deteriorated, the antibiotic therapy was switched to intravenously administered clindamycin, cloxacillin, and meropenem. Due to further deterioration and isolation of M. chelonae from the blood culture, antimicrobial therapy was changed to azithromycin and amikacin. Drug-test sensitivity was performed, and the isolate was susceptible to clarithromycin only. The patient‚??s deteriorating status prevented orally administered medication with clarithromycin (parenteral formulation is not registered ...

Intravitreal Injections Might Be Best for Ocular Toxoplasmosis: Study

Intravitreal injection of clindamycin and dexamethasone for active ocular toxoplasmosis may be safer and more convenient than standard treatment, according to researchers in Iran. Reuters Health Information (Source: Medscape Pharmacist Headlines)

Detection of inducible clindamycin resistance among Staphylococcal isolates from different clinical specimens in western India

Conclusions: Fifty percent of Staphylococcal spp. were ER among which 23.48&#x0025; were iMLS B phenotypes. Eighty-seven per cent of iMLS B phenotypes were observed to be methicillin-resistant. The high frequency of methicillin resistance isolates (87.12&#x0025;) with in vitro inducible clindamycin resistance at our institute raises concern of clindamycin treatment failures with methicillin-resistant infections. So we recommend that microbiology laboratories should include the D-test for inducible resistance to clindamycin in the routine antibiotic susceptibility testing. (Source: Journal of Postgraduate Medicine)<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>

EVOCLIN (Clindamycin Phosphate) Aerosol, Foam [Stiefel Laboratories Inc]

Updated Date: Aug 24, 2010 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

An increase in non-toxigenic Corynebacterium diphtheriae infections in Poland ‚?? molecular epidemiology and antimicrobial susceptibility of strains isolated from past outbreaks and those currently circulating in Poland

Conclusions: The genetic similarity of non-toxigenic C. diphtheriae strains causing infection suggests that the strains represent a single clone. They may possess additional virulence genes in a chromosome, related with higher pathogenicity and invasiveness. The genetic changes have not been followed by resistance to antibiotics. (Source: International Journal of Infectious Diseases)

Subinhibitory concentrations of protein synthesis-inhibiting antibiotics promote increased expression of the agr virulence regulator and production of phenol-soluble modulin cytolysins in community-associated MRSA.

Authors: Joo HS, Chan JL, Cheung GY, Otto M Tetracycline, clindamycin, and other protein synthesis inhibitors at subinhibitory concentrations significantly increased expression of the pivotal virulence regulator agr and production of the agr-regulated cytolytic phenol-soluble modulins in the community-associated MRSA strain USA300. Our results suggest that such protein synthesis inhibitors may exacerbate progression of CA-MRSA disease when applied at concentrations that are too low or when treating infections caused by strains resistant to those antibiotics. PMID: 20713669 [PubMed - as supplied by publisher] (Source: Antimicrobial Agents and Chemotherapy)

Antimicrobial resistance in colonizing group B Streptococci before the implementation of a Swedish intrapartum antibiotic prophylaxis program

Abstract&nbsp;&nbsp;The prevalence of antibiotic resistance and their genetic determinants in colonizing group B streptococci (GBS) sampled in a Swedish nationwide survey was examined. In five GBS isolates (1.3%), kanamycin/amikacin resistance and the presence of the aphA-3 gene was identified. Three of these isolates carried the aad-6 gene and were streptomycin-resistant. Screening with kanamycin and streptomycin 1,000-őľg disks enabled a rapid and easy detection of these isolates. In all, 312/396 (79%) GBS were tetracycline-resistant and 95% of the examined isolates harbored the tetM gene. Among the 22 (5.5%) GBS resistant to erythromycin and/or clindamycin, the ermB gene was detected in nine isolates (41%) and erm(A/TR) in ten isolates (45%). A high level of erythromycin and clindamy...

Randomized Trial of Intravitreal Clindamycin and Dexamethasone versus Pyrimethamine, Sulfadiazine, and Prednisolone in Treatment of Ocular Toxoplasmosis

Purpose: To compare the efficacy of intravitreal injection of clindamycin and dexamethasone with classic treatment for ocular toxoplasmosis.Design: Prospective, randomized single-masked clinical trial.Participants: A total of 68 patients with active ocular toxoplasmosis were assigned randomly to 2 treatment groups: 34 in the intravitreal clindamycin plus dexamethasone (IVCD) group and 34 in the classic treatment (CT) group.Intervention: The IVCD group received 1 to 3 injection(s) of 1 mg intravitreal clindamycin and 400 őľg dexamethasone, and the CT group received 6 weeks of treatment with pyrimethamine and sulfadiazine plus prednisolone. Antitoxoplasmosis antibodies (immunoglobulin [Ig] M and IgG) were measured using an enzyme-linked immunosorbent assay.Main Outcome Measures: Changes in r...<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>

CLINDAMYCIN HYDROCHLORIDEcapsule [Contract Pharmacy Services-PA]

Updated Date: Aug 10, 2010 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

CLINDAMYCIN (Clindamycin) Injection, Solution [General Injectables Vaccines, Inc]

Updated Date: Aug 9, 2010 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

Overexpression of Resistance-Nodulation-Cell Division Pump AdeFGH confers Multidrug Resistance in Acinetobacter baumannii.

Authors: Coyne S, Rosenfeld N, Lambert T, Courvalin P, P√?¬©richon B Acinetobacter baumannii is a major nosocomial pathogen which frequently develops multidrug resistance by acquisition of antibiotic resistance genes and overexpression of intrinsic efflux systems, such as the RND efflux pumps AdeABC and AdeIJK. A third RND system was characterized by studying spontaneous mutants BM4663 and BM4664, that were selected in presence of chloramphenicol and norfloxacin, respectively, from the AdeABC, AdeIJK defective derivative A. baumannii BM4652. They exhibited enhanced resistance to fluoroquinolones, tetracycline-tigecycline, chloramphenicol, clindamycin, trimethoprim, sulfamethoxazol, sodium dodecyl sulfate and dyes such as ethidium bromide, safranin O, and acridine orange. Comparison of ...

Mutations in 23S rRNA at the peptidyl transferase center and their relationship to linezolid binding and cross resistance.

This study emphasizes that effects of rRNA mutations at the PTC are organism-dependent. Moreover, the data show a non-predictable cross-resistance pattern between linezolid, chloramphenicol, clindamycin, and valnemulin. The data underscore the significance of mutations at distal nucleotides, either alone or in combination with other mutated nucleotides, in contributing to linezolid resistance. PMID: 20696869 [PubMed - as supplied by publisher] (Source: Antimicrobial Agents and Chemotherapy)

Veltin (Clindamycin Phosphate and Tretinoin Gel) - updated on RxList

Veltin (Clindamycin Phosphate and Tretinoin Gel) drug description - FDA approved labeling for prescription drugs and medications at RxList (Source: RxList - New and Updated Drug Monographs)<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>

The Search and Destroy Strategy Prevents Spread and Long‚?źterm Carriage of MRSA; Results from Follow‚?źup Screening of a Large ST22 (E‚?źMRSA 15) Outbreak in Denmark

In conclusion decolonization of MRSA carriers is possible, but should include treatment of household members and environment. (Source: Clinical Microbiology and Infection)

In‚?źVitro Activities of Tetracyclines, Macrolides, Fluoroquinolones and Clindamycin against Mycoplasma hominis and Ureaplasma ssp. isolated in Germany over 20 years

ABSTRACTBased on the increase of resistance of genital mycoplasmas to effective antibacterials with worldwide significant differences, we compared the susceptibilities of a wide range of clinical isolates over several years. The susceptibilities of 469 M. hominis (n=290) and ureaplasma (n=179) isolates, collected during 1983 and 1989‚?ź2004, to eleven antibacterials were determined by agar dilution method. Additionally, the results from the routine testing (2005‚?ź2008) were considered. Doxycycline was the most active tetracycline against ureaplasmas and M. hominis (MIC90s, 1 and 8 mg/L, respectively). Significantly more M. hominis isolates (‚?ľ10‚?ź13%) were resistant to tetracyclines compared to ureaplasmas (‚?ľ1‚?ź3%). Ofloxacin was effective against both species (&gt;95% susceptibility...

Molecular characterization and antimicrobial susceptibility profiles in Streptococcus agalactiae colonizing strains: association of erythromycin resistance with subtype III‚?ź1 genetic clone family

In conclusion, considering the association of genetic lineages expressing type III capsule with macrolide resistance, and its relation with invasive infection, epidemiological surveillance of this genotype is crucial. (Source: Clinical Microbiology and Infection)

Pyomyoma in a premenopausal woman with fever of unknown origin.

CONCLUSION: Pyomyoma may be difficult to diagnose, especially in women with a nonspecific clinical presentation. Delayed diagnosis may result in serious complications, and surgery and broad spectrum antibiotics are indicated. PMID: 20664442 [PubMed - in process] (Source: Obstetrics and Gynecology)

[Evaluation of MicroScan Synergies plus Positive Combo 3 Panels for Identification and Antimicrobial Susceptibility Testing of Staphylococcus aureus and Enterococcus Species.]

CONCLUSIONS: The panels compared favorably with conventional methods for the ID and AST of S. aureus. However, we expected a better performance for ID of E. faecium and AST using Synercid. PMID: 20805709 [PubMed - in process] (Source: The Korean Journal of Laboratory Medicine)<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>

CLEOCIN (Clindamycin Phosphate) Suppository [Pharmacia And Upjohn Company]

Updated Date: Jul 30, 2010 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

VELTIN (Clindamycin Phosphate And Tretinoin) Gel [Stiefel Laboratories Inc]

Updated Date: Jul 30, 2010 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

CLINDAMYCIN HYDROCHLORIDEcapsule [McKesson Packaging Services Business Unit Of McKesson Corporation]

Updated Date: Jul 29, 2010 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

CLINDAMYCIN HYDROCHLORIDEcapsule, Gelatin Coated [Contract Pharmacy Services-PA]

Updated Date: Jul 29, 2010 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

ACANYA (Clindamycin Phosphate And Benzoyl Peroxide) Gel [Coria Laboratories]

Updated Date: Jul 28, 2010 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>

Comparison of tretinoin 0.05% cream and 3% alcohol-based salicylic acid preparation in the treatment of acne vulgaris

Conclusions Combination of SA + CDP and all-TRA + CDP was effective in decreasing lesion counts and well tolerated with minimal local cutaneous reactions in patients with mild to moderate AV. (Source: Journal of the European Academy of Dermatology and Venereology)

Trends in antibiotic resistance in Prevotella species from patients of the University Hospital of Maxillofacial Surgery, Sofia, Bulgaria, in 2003-2009.

In conclusion, in Prevotella strains from patients with head-and-neck infections, the resistance rate to penicillin increased, that to clindamycin remained stable and the nonsusceptibility rate to tetracycline decreased during the period. Activity against &gt;99% of Prevotella strains was observed with metronidazole and BL/BLIs. The penicillin resistance and tetracycline nonsusceptibility were associated with the year of study, national antibiotic consumption and possibly with previous treatment (for tetracycline). The evolution of penicillin resistance in Prevotella strains was highly dynamic. PMID: 20670687 [PubMed - as supplied by publisher] (Source: Anaerobe)

Tongli Pharmaceuticals (USA) Inc. Has Three Products Included In Essential Drug List

Tongli Pharmaceuticals (USA) Inc. (OTCBB:TGLP), announced the following three of its products have been included in China's Essential Drug List ("EDL"): Calcium Gluconate Oral Liquid, Metformin Hydrochloride Tablets, Clindamycin Hydrochloride. (Source: Pharmaceutical Online News)

Macrolide-resistant Streptococcus pyogenes from Chinese pediatric patients in association with Tn916 transposons family over a 16-year period

This study demonstrates the increase in macrolide resistance in S. pyogenes in Chinese children over a 16-year period. The phenomenon may be related not only with the shift in the emm types but also with the change of macrolide-resistant mechanisms. The change of Tn916 family among the isolates may be related with the increased resistance. (Source: Diagnostic Microbiology and Infectious Disease)

Tularemia presenting as a cervical abscess

A 40-year-old man presented with two months of progressive left neck swelling, night sweats, and fatigue. He worked as a hunting guide in New Mexico and reported multiple bites from insects, including deer flies, on the job. He had been treated with penicillin, cephalexin, and clindamycin, but his symptoms persisted. On presentation to our institution, his examination was notable for a temperature of 97.4¬įF, clear throat, and a 4 √? 5-cm erythematous, mildly tender mass in the left neck with an area of fluctuance superiorly (). Fine needle aspiration revealed necrotizing acute inflammation without granulomas; cultures were negative, and smears were negative for acid-fast bacilli. Chest x-ray was clear, and a tuberculin skin test was negative. A contrast-enhanced computed tomography (CT) s...<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>

Antimicrobial resistance 1979&#x2013;2009 at Karolinska hospital, Sweden: normalized resistance interpretation during a 30-year follow-up on Staphylococcus aureus and Escherichia coli resistance development

Kronvall G. Antimicrobial resistance 1979[ndash]2009 at Karolinska hospital, Sweden: normalized resistance interpretation during a 30-year follow-up on Staphylococcus aureus and Escherichia coli resistance development. APMIS 2010. To utilize a material of inhibition zone diameter measurements from disc diffusion susceptibility tests between 1979 and 2009, an objective setting of epidemiological breakpoints was necessary because of methodological changes. Normalized resistance interpretation (NRI) met this need and was applied to zone diameter histograms for Staphylococcus aureus and Escherichia coli isolates. The results confirmed a slow resistance development as seen in Northern countries. The S. aureus resistance levels for erythromycin, clindamycin and fusidic acid in 2009 were 3.2%, 1....

The need for continued monitoring of antibiotic resistance patterns in clinical isolates of Staphylococcus aureus from London and Malta

Conclusion: The data presented here suggests that the monitoring of changing resistance profiles locally in maintaining treatment efficacy to resistant pathogens. (Source: Annals of Clinical Microbiology and Antimicrobials)

Necrotizing myositis of the deltoid following intramuscular injection of anabolic steroid

A 25-year-old male bodybuilder was admitted in septic shock. He had marked limitation of left shoulder movement with non-fluctuant swelling extending from the acromio-clavicular joint to the postero-lateral and anterior deltoid. Lesions consistent with herpes labialis were also noted. A computed tomography scan demonstrated collections of both gas and fluid within the deltoid muscle and numerous pockets of gas within the soft tissues conforming to the fascial planes (). On further questioning he admitted to injecting himself with anabolic steroids into the left deltoid region six days prior to admission. He underwent emergency drainage with debridement of large areas of necrotic muscle and a fasciotomy of the upper arm. Gemella morbillorum and Veillonella were isolated from culture of pus....

Sinobiopharma Announces Agreement to Manufacture and Co-Promote Two Products

NANTONG CITY, China, July 20, 2010 (GLOBE NEWSWIRE) -- Sinobiopharma, Inc. (OTCBB:SNBP) ("Sinobiopharma" or, the "Company") is pleased to announce that it has signed an agreement with Anhui Xianfeng Pharmaceuticals Co., Ltd ("Xianfeng") to manufacture and co-market Clindamycin, an antibiotic, and L-alanyl-L-glutamine, a parenteral nutrition. (Source: Medical News (via PRIMEZONE))

Acanya Gel (Clindamycin Phosphate 1.2% and Benzoyl Peroxide 2.5%) - updated on RxList

Acanya Gel (Clindamycin Phosphate 1.2% and Benzoyl Peroxide 2.5%) drug description - FDA approved labeling for prescription drugs and medications at RxList (Source: RxList - New and Updated Drug Monographs)<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>

Stiefel, a GSK company, Receives FDA Approval of Veltin (clindamycin phosphate and tretinoin) Gel 1.2%/0.025%

Research Triangle Park, N.C. ‚?? July 16, 2010 ‚?? Stiefel, a GSK company, today announced that the U.S. Food and Drug Administration (FDA) has approved Veltin Gel for the topical treatment of acne vulgaris in patients 12 years and older. Stiefel... (Source: Drugs.com - New Drug Approvals)

CLINDAMYCIN HYDROCHLORIDEcapsule [TEVA Pharmaceuticals USA Inc]

Updated Date: Jul 12, 2010 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

Detection of cross-infection associated to a Brazilian PCR-ribotype of Clostridium difficile in a university hospital in Rio de Janeiro, Brazil.

This study aimed to isolate and characterize C. difficile strains from samples obtained of a university hospital (HUCFF) in Rio de Janeiro city, Brazil. CDI was identified by ELISA in 27.1% of HUCFF-in-patients enrolled in the study, and the bacterium was recovered from eight of these fecal samples. All strains, except one, presented tcdA and tcdB genes and presented neither the cdtA and cdtB genes nor any significant deletions in the tcdC gene. All strains were sensitive to metronidazole, vancomycin and moxifloxacin, and resistant to clindamycin, ciprofloxacin and levofloxacin. PCR-ribotyping and PFGE revealed four different clonal types among the isolates. The Brazilian PCR-ribotype 133 accounted for 50% of strains isolated, and PCR-ribotype 233 strains were obtained from 25% of the in-p...

EVOCLIN (Clindamycin Phosphate) Aerosol, Foam [Stiefel Laboratories Inc]

Updated Date: Jul 9, 2010 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

CLINDAMYCIN PALMITATE HYDROCHLORIDEgranule, For Solution [Paddock Laboratories, Inc.]

Updated Date: Jul 8, 2010 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>

Emergence of Clindamycin-Resistant Streptococcus pyogenes Isolates Obtained from Patients with Severe Invasive Infections in Japan.

Authors: Ikebe T, Wada A, Oguro Y, Ogata K, Katsukawa C, Isobe J, Shima T, Suzuki R, Ohya H, Tominaga K, Okuno R, Uchitani Y, Watanabe H, PMID: 20657078 [PubMed - as supplied by publisher] (Source: Japanese Journal of Infectious Diseases)

Progressive Macular Hypomelanosis Successfully Treated With Topical Clindamycin and Benzoyl Peroxide.

Authors: Echeverr√?¬≠a B, Botella-Estrada R, Escutia B, Guill√?¬©n C PMID: 20738984 [PubMed - as supplied by publisher] (Source: Actas Dermo-Sifiliograficas)

CLEOCIN (Clindamycin Phosphate) Cream [Pharmacia And Upjohn Company]

Updated Date: Jun 30, 2010 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

Benzoyl Peroxide/Salicylic Acid Wins As Initial Acne Treatment

Benzoyl peroxide with salicylic acid works better than benzoyl peroxide with clindamycin for the initial treatment of acne, but after 10 to 12 weeks there is little difference in results between the two treatments, according to research published in the July issue of the Journal of the American Academy of Dermatology. (Source: Modern Medicine)

Clindamycin-resistant Staphylococcus aureus in foot ulcers of patients with diabetes

We read with interest the article of Woodford and Livermore about the increasing numbers of Gram-positive resistant bacteria such as methicillin-resistant Staphylococcus aureus (MRSA). These numbers are impressive and at the same time ominous. The MRSA levels in The Netherlands are still low, however, recently we observed a rise in the number of clindamycin-resistant S. aureus (CRSA) at the diabetic foot outpatient clinic of the Academic Medical Center (AMC) in Amsterdam, The Netherlands. These strains were also ciprofloxacin-resistant. Since the first line of treatment for clinically infected deep diabetic foot ulcers consists of clindamycin and ciprofloxacin in our center, as well as in many others, we aimed to identify the prevalence and risk factors of CRSA infected foot ulcers in our ...<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>

CLEOCIN PHOSPHATE (Clindamycin Phosphate) Injection, Solution [Pharmacia And Upjohn Company]

Updated Date: Jun 25, 2010 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

Expand the Pharyngitis Paradigm for Adolescents and Young Adults: Centor RM. Ann Intern Med 2009;151:812‚??5

This review article highlights Fusobacterium necrophorum as an important and under-recognized etiology of infectious pharyngitis in adolescents and young adults. Previous studies and standard-of-care guidelines have focused primarily on treating streptococcal pharyngitis, with a goal of reducing post-streptococcal complications such as rheumatic fever. Many algorithms recommend that non-streptococcal pharyngitis should not be treated with antibiotics. The author suggests that pharyngitis caused by F. necrophorum should also be strongly considered for treatment with antibiotics. Three studies are cited suggesting that the overall prevalence of these bacteria in patients with clinical pharyngitis and tonsillitis is approximately 10%, very similar to the prevalence of Group A streptococcus in...

Clindamycin: Sweet's syndrome: case report

(Source: Reactions)

Susceptibility of Endodontic Pathogens to Antibiotics in Patients with Symptomatic Apical Periodontitis

Conclusions: Based on the study results, penicillin and amoxicillin are suitable antibiotics for treatment of endodontic infection when conventional root canal treatment alone is insufficient. Clindamycin could be advised for penicillin-allergic patients with primary endodontic infections. (Source: Journal of Endodontics)

In reply

In my recent letter to the editor, I tried to emphasize the importance of Staphylococcus species bacteria (rather than the classically implicated streptococcal-based infections) in the oral cavity and their possible relations to the very large number of late prosthetic joint infections caused by this group of organisms. Given the sometime resistance of Staphylococcus to ő≤-lactam antibiotics, including amoxicillin and some cephalosporins, the German Society of Orthopaedics and Traumatology has devised an antibiotic regimen (amoxicillin-clavulanate 2 g or clindamycin 600 mg; shortly before and 4 hours after dental care) that is effective against staphylococcal and streptococcal bacteremias that might arise from the oral cavity in association with surgical management of infections. (Source: ...<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>

Antimicrobial Resistance of Staphylococcus Aureus Isolated From Bovine Mastitis in China

In this report, the results of antibiotic susceptibility test, carried out on 236 Staphylococcus aureus isolated from milk samples which were collected from cases of mastitis in cow herds of China, are presented. The regions and number of isolates include Inner Mongolia (112), Hebei (58) and Heilongjiang (66). Susceptibility to ampicillin, penicillin G, amoxicillin, piperacillin, cephalexin, cephazolin, cefotaxime, ceftazidime, cefoxitin, SMZ-TMP, gentamycin, kanamycin, norfloxacin, ciprofloxacin, ofloxacin, furaxone, torlamician, roxithromycin, clindamycin and vancomycin was determined by the disc diffusion method. Antibiotic susceptibility testing showed 87.30% (206 of 236) isolates were resistant to penicillin G. This result compares with the reports from other countries; the overall le...

CLINDAMYCIN (Clindamycin Phosphate) Injection [Bedford Laboratories]

Updated Date: Jun 11, 2010 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

CLINDAMYCIN HYDROCHLORIDEcapsule [TEVA Pharmaceuticals USA Inc]

Updated Date: Jun 10, 2010 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

Antibiotic resistance of subgingival species in chronic periodontitis patients

Conclusion: The results of the present study suggest that periodontal microorganisms in patients with chronic periodontitis can be resistant to the antimicrobial agents commonly used in anti-infective periodontal therapy. We suggest that the indiscriminate use of antimicrobials could result in the appearance of more highly antibiotic-resistant strains of bacteria associated with periodontal diseases in our population compared with the populations of other countries. (Source: Journal of Periodontal Research)

Detection of a new erm(X)-mediated antibiotic resistance in Egyptian cutaneous propionibacteria.

Authors: El-Mahdy TS, Abdalla S, El-Domany R, Mohamed MS, Ross JI, Snelling AM A total of 107 antibiotic-resistant propionibacteria were isolated from the face of 102 Egyptian acne patients, dermatology staff and controls. Erythromycin-clindamycin-resistant propionibacteria were chosen to detect erm(X) gene and it was detected in 29 of 107 (27%) strains. However, just 7 strains had IS1249I, 3 of them had also Tn5432. The erm(X) gene which is not carried on Tn5432 confers inducible resistance to telithromycin by erythromycin or clindamycin. The DNA sequences of the PCR amplification products of this new erm(X)-mediated antibiotic resistance showed &gt;99% identity to the erm(X) gene isolated from a Corynebacterium jeikeium. Southern blotting analysis of the erm(X)-specific probe shows t...<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>

Antibiotic susceptibility patterns of Staphylococcus aureus isolates from Australian children

Conclusions: These data support current Australian recommendations for the use of flucloxacillin or a first-generation cephalosporin as initial treatment of non-life-threatening staphylococcal infections. However, broad spectrum antibiotic therapy including agents that are effective against MRSA should be considered for more serious infections. Appropriate specimens should be collected for susceptibility testing to enable directed treatment for MRSA and other resistant organisms. This study highlights the importance of using local, age-specific data in planning antibiotic treatment guidelines, as results vary substantially from city to city and between adults and children. (Source: Journal of Paediatrics and Child Health)

Antimicrobial resistance in clinical isolates of Streptococcus pneumoniae in a tertiary hospital in Kuwait, 1997‚??2007: Implications for empiric therapy

Conclusion: The study demonstrated that antimicrobial resistance of S. pneumoniae is increasing in Kuwait. However, the results of MIC determinations indicated that penicillin can still be used for therapy of non-meningeal infections. High prevalence of erythromycin resistance suggests that therapy of pneumonia with a macrolide alone may result in failure and should be based on results of susceptibility testing. (Source: Journal of Infection and Public Health)

In-Vitro activities of tetracyclines, macrolides, fluoroquinolones and clindamycin against Mycoplasma hominis and Ureaplasma ssp. isolated in Germany over 20&nbsp;years

Clin Microbiol Infect Antimicrobial resistance in genital mycoplasmas is increasing and shows global variation. We determined the susceptibilities of 469 mycoplamas, comprising 290 Mycoplasma hominis and 179 ureaplasma isolates collected during 1983 and 1989[ndash]2004, to eleven antibacterials by agar dilution. Additionally, we analyzed the results of routine E-testing during 2005[ndash]2008. Doxycycline was the most active tetracycline with (MIC90 of 1 and 8 mg/L for ureaplasmas and M. hominis, respectively. Significantly more M. hominis isolates (approximately 10[ndash]13%) than ureaplasmas (approximately 1[ndash]3%) were resistant to tetracyclines. Ofloxacin was effective against both species (>95% susceptibility). Ciprofloxacin was moderately active against M. hominis and less active ...

Inducible clindamycin resistance in Staphylococcus aureus isolated from clinical samples

Conclusion: Study showed that D test should be used as a mandatory method in routine disc diffusion testing to detect inducible clindamycin resistance. (Source: Indian Journal of Medical Microbiology)

Septic pneumonic tularaemia caused by Francisella tularensis holarctica biovar II.

Authors: Fritzsch J, Splettstoesser W This case of pneumonic tularaemia elucidates two aspects: It is the first documented case of bacteraemia caused by Francisella tularensis holarctica biovar II. Furthermore, it illustrates remission of septic pneumonic tularaemia without appropriate anti-infective therapy: A blood culture from a patient with community-acquired pneumonia was found to be positive for Francisella tularensis holarctica biovar II after ten days of cultivation. Meanwhile, the patient had been treated with ceftriaxone followed by sultamicillin and clindamycin. The patient continued suffering from fever till 40.7 degrees C and rising C-reactive protein (CRP) for 4 days before fever and CRP declined. The isolated strain was later tested to be resistant against the used antib...<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>

Clindamycin: A Scary Antibiotic?

My wife recently took a daily dosage of 600 mg of Clindamycin for a urinary tract infection. If we had known anything about the potential side effects, we wouldn't have gone near it. What coping strategies do you suggest? (Source: Dr. Weil Q and A)

Antibiotic Management of Staphylococcus aureus Infections in US Children's Hospitals, 1999-2008

CONCLUSIONS: Antibiotic prescribing patterns for the treatment of S aureus infections have changed significantly during the past decade, reflecting the emergence of community-associated MRSA. Clindamycin is now the most commonly prescribed antibiotic for S aureus infections among hospitalized children. The substantial use of clindamycin emphasizes the importance of continuous monitoring of local S aureus susceptibility patterns. (Source: PEDIATRICS)

Changing molecular epidemiology of group B streptococcus in Korea.

Authors: Seo YS, Srinivasan U, Oh KY, Shin JH, Chae JD, Kim MY, Yang JH, Yoon HR, Miller B, Debusscher J, Foxman B, Ki M The prevalence of group B streptococcus (GBS) among pregnant women and disease burdens in neonates and adults are increasing in Korea. Colonizing isolates, collected by screening pregnant women (n=196), and clinical isolates collected from clinical patients throughout Korea (n=234), were serotyped and screened for antibiotic resistance. Serotype III (29.8%) and V (27.7%) predominated, followed by Ia (17.0%). Antibiotic resistance was higher among clinical than colonizing isolates for erythromycin (35.1% and 26.9%; P=0.10) and for clindamycin (49.4% and 42.1%; P=0.17). erm(B) occurred in 91.9% of erythromycin resistant isolates, and 84.0% of isolates resistant to clin...

[Activity of daptomycin, ciprofloxacin, clindamycin and cotrimoxazole against coagulase-negative Staphylococcus strains with diminished susceptibility to vancomycin.]

Conclusions. The MIC levels to daptomycin were not influenced by the increase in the MIC for vancomycin. There was no statistically significant difference for the sensitivity of ciprofloxacin between the two groups of vancomycin. Regardless of vancomycin, there were a clear relationship between the sensitivity of ciprofloxacin with clindamycin and cotrimoxazole. PMID: 20559606 [PubMed - in process] (Source: Revista Espanola de Quimioterapia)

Bacterial coinfection and antimicrobial resistance in patients with paranasal sinus fungus balls.

CONCLUSIONS: Bacterial coinfections were identified in more than two thirds of patients with fungus balls and purulent secretions. This finding suggests that bacterial infection may influence the development and persistence of clinical symptoms in a substantial portion of fungus ball cases. PMID: 20583740 [PubMed - in process] (Source: The Annals of Otology, Rhinology, and Laryngology)<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>

In‚?źVitro activities of tetracyclines, macrolides, fluoroquinolones and clindamycin against Mycoplasma hominis and Ureaplasma ssp. isolated in Germany over 20‚??years

(Source: Clinical Microbiology and Infection)

Spontaneous bacterial peritonitis caused by Streptococcus bovis: case report and review of the literature.

We describe the first case of SBP at the University Hospital of Santa Maria (HUSM) caused by S. bovis, resistant to the antibiotics erythromycin and clindamycin (inducible clindamycin resistance detected by disk diffusion test using the D-zone test). PMID: 20835516 [PubMed - in process] (Source: Braz J Infect Dis)

What Are the Complications of Pneumonia?

Discussion Pneumonia is an inflammation of the lung parynchema with consolidation of the tissue and filling of the alveolar air space with exudate, fibrin and inflammatory cells. It is the most common cause of pediatric death in the world and is described as the &#8220;forgotten killer of children&#8221; by UNICEF and the WHO. This is particularly true in developing countries. But while the United States and other developed countries see fewer deaths and morbidity related to pneumonia, complications of pneumonia still occur. The most common organisms causing outpatient pneumonias in the U.S. are: Chlamydia pneumoniae, Haemophilus influenzae, Mycoplasma pneumoniae, Streptococcus pneumoniae, and a variety of respiratory viruses. Vaccines to combat pneumonia are available and include: Haemoph...

Periorbital and orbital cellulitis: a 10-year review of hospitalized children.

Conclusions. Upper respiratory infection and sinusitis are the most important predisposing factors for periocular infection. Streptococcus species are the predominant causative agents. Both diseases can usually be successfully treated with intravenous antibiotics, but some patients may require surgery to control extensive infection. PMID: 20544674 [PubMed - as supplied by publisher] (Source: European Journal of Ophthalmology)

ANTIROBE (Clindamycin Hydrochloride) Capsule [Pharmacia And Upjohn Company]

Updated Date: May 26, 2010 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>

Impregnation of bone chips with antibiotics and storage of antibiotics at different temperatures: an in vitro study

Conclusions: Storage of antibiotics in frozen form or storage of antibiotic pills at temperatures up to 37degreesC for 12 months does not affect their activity. However, storage of antibiotic solutions at temperatures above 20degreesC does affect the activity of some of the antibiotics investigated. The in vitro dose-response curve can be used to determine the optimal concentration(s) for local application. It provides the opportunity to determine the antibiotic content of bone chips, and thus the amount of antibiotics available locally after application. (Source: BMC Musculoskeletal Disorders)

Activity of tigecycline and comparators against recent clinical isolates of Finegoldia magna from Europe

Abstract&nbsp;&nbsp;A total of 206 clinical isolates of Finegoldia magna were collected during the period 2007‚??2009 from six European countries. The majority of isolates were from body fluids (n‚??=‚??83; 40.3%) or wounds (n = 82; 39.8%). All isolates were susceptible to tigecycline, meropenem, metronidazole and piperacillin / tazobactam, though susceptibility to penicillin (86.4‚??87.4%) and clindamycin (78.2‚??93.3%) were more variable. Content Type Journal ArticleCategory ArticleDOI 10.1007/s10096-010-0962-7Authors S. P. Hawser, IHMA Europe S√†rl 4 Route de la Corniche 1066 Epalinges Switzerland Journal European Journal of Clinical Microbiology & Infectious DiseasesOnline ISSN 1435-4373Print ISSN 0934-9723 (Source: European Journal of Clinical Microbiology and Infectiou...

Meta-analysis comparing efficacy of benzoyl peroxide, clindamycin, benzoyl peroxide with salicylic acid, and combination benzoyl peroxide/clindamycin in acne

Conclusion: At early time points, 5% BPO + SA had the best profile. BPO/CL was only incrementally better than BPO alone but was superior to CL alone. At later time points, 5% BPO + SA was similar to BPO/CL. (Source: Journal of the American Academy of Dermatology)

Antibiotic Patterns for S. Aureus in Children Have Changed

Since the emergence of community-associated methicillin-resistant Staphylococcus aureus infections, antibiotic treatment for hospitalized children with S. aureus infections has changed dramatically, and clindamycin has become the primary antibiotic treatment for those infections, according to research published online May 17 in Pediatrics. (Source: Modern Medicine)

Intravitreal Clindamycin and Dexamethasone for Zone 1 Toxoplasmic Retinochoroiditis at Twenty-four Months

Conclusions: The combination of intravitreal clindamycin and dexamethasone was associated with resolution of zone 1 TRC and functional and anatomic improvement in patients who did not tolerate, had contraindications to, or did not respond to oral medications.Financial Disclosure(s): The author(s) have no proprietary or commercial interest in any materials discussed in this article. (Source: Ophthalmology)<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>

Serotype distribution of invasive pneumococcal disease during the first 60 days of life.

Authors: Im√?¬∂hl M, van der Linden M, Mutscher C, Reinert RR A total of 8172 isolates from invasive pneumococcal disease was collected from 1992 to 2006 in Germany. From these, 88 were from children &lt;/=60 days of age, where the leading serotypes were 7F (14.8%), 1 and 14 (13.6% each), 3 (8.0%), and 9V (6.8%). The serotype distribution found in this study suggests that pneumococcal infections are transferred to them both by older siblings and adults. The theoretical serotype coverages for the pneumococcal vaccines were 36.8% (7-valent), 67.8% (10-valent), 80.5% (13-valent) and 89.7% (23-valent). Since the serotype distribution among children &lt;/=60 days differs considerably from those vaccinated against pneumococci (6 or 8 weeks up to 5 years), our data suggest, that future epidem...

BENZACLIN (Clindamycin Phosphate And Benzoyl Peroxide) Gel [Dermik Laboratories]

Updated Date: May 6, 2010 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

Profile of methicillin-resistant Staphylococcus aureus among nursing home residents in Hawai'i.

The objective of this study was to describe MRSA epidemiology among residents in skilled nursing and intermediate care facilities (SNF/ICF) in Hawai'i, using a statewide, population-based antimicrobial resistance surveillance system. From 2000 to 2005, proportions of MRSA increased significantly during the 6-year study period, from 35.0% in 2000 to 58.6% in 2005 (p &lt; 0.001). High levels of MRSA resistance to several commonly used antibiotics were observed, e.g., the level of MRSA resistance to clindamycin, ciprofloxacin, and erythromycin was at 77%, 90%, and 89% respectively. Nevertheless, there is a significant difference in the MRSA resistance pattern against certain antimicrobials in different geographic areas. For example, the level of MRSA resistance to trimethoprim-sulfamethoxazol...

No Change in the Incidence of Ampicillin-Resistant, Neonatal, Early-Onset Sepsis Over 18 Years

CONCLUSIONS: Predominant use of penicillin G for GBS prophylaxis resulted in decreased incidence of EOS. No change in the incidence of ampicillin-resistant EOS was observed, but resistant cases were associated with peripartum ampicillin exposure. These findings suggest that obstetricians should consider preferential use of penicillin G for GBS prophylaxis. (Source: PEDIATRICS)

Antimicrobial susceptibility of Bacteroides fragilis group isolates in Europe: 20&nbsp;years of experience

Clin Microbiol Infect The susceptibilities of 824 Bacteroides fragilis group isolates against nine antibiotics were evaluated in a Europe-wide study involving 13 countries. Species determination, by different methods, was carried out on all but one isolate. Resistance rates were evaluated according to species and geographical areas via CLSI and the European Committee on Antimicrobial Susceptibility Testing (EUCAST) breakpoints. The present data were compared with those obtained 10 and 20 years ago at a European level. High-level resistance (MIC [ge]64 mg/L) to ampicillin was observed in 44.5% of the strains, which is a significant increase relative to 20 years ago (16%). Piperacillin/tazobactam was more active than amoxicillin/clavulanic acid (3.1% and 10.4% resistance, respectively), agai...<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>

Preferred treatment and prevention strategies for recurrent community-associated methicillin-resistant Staphylococcus aureus skin and soft-tissue infections: A survey of adult and pediatric providers

Among pediatric and adult providers, 70% preferred trimethoprim-sulfamethoxazole for directed treatment of community-associated methicillin-resistant Staphylcoccus aureus skin and soft-tissue infections, although a higher proportion of pediatric compared with adult providers favored clindamycin (36% vs 8%, respectively, P < .0001). For recurrent infections, 88% of providers employed at least 1 topical decolonization strategy. (Source: American Journal of Infection Control)

Ceftazidime/clindamycin: AGEP with acute renal failure in an elderly patient: case report

(Source: Reactions)

Drug susceptibility and clonality of methicillin-resistant Staphylococcus epidermidis in hospitalized patients with hematological malignancies

Conclusions&nbsp;&nbsp;Our results represent two significant findings. One is the major capability of MRSE to colonize patients. The other is that some MRSE isolates proved to be sensitive to clindamycin, minocycline, and cephalosporin, so that using antibiotics to which MRSE is sensitive as first-line therapy can avoid the need for vancomycin in clinical settings. Content Type Journal ArticleCategory Original ArticleDOI 10.1007/s11845-010-0481-7Authors K. Nomura, Iwate Medical University Division of Hematology and Oncology, Internal Medicine, School of Medicine Uchimaru 19-1 Morioka 020-8505 JapanE. Mizumachi, Hiroshima University Graduate School of Biomedical Sciences Department of Bacteriology Hiroshima JapanM. Yamashita, Iwate Medical University Division of Hematology and ...

Antimicrobial resistance of Streptococcus pneumoniae in Southeast Austria, 1997‚??2008

Abstract: Antibiotic resistance in Streptococcus pneumoniae has increased worldwide but varies within geographical regions. We conducted a retrospective analysis of resistance in S. pneumoniae over a 12-year period to assess local and temporal trends in antibacterial resistance. From 1997 to 2008, a total of 1814 non-duplicate S. pneumoniae isolates were identified at the Institute of Hygiene, Microbiology and Environmental Medicine, Medical University of Graz, Austria. Antibiotic resistance was determined by the Clinical and Laboratory Standards Institute (CLSI) disk diffusion test. For penicillin, the minimum inhibitory concentration was determined by Etest. Susceptibility was defined according to CLSI interpretive criteria. For penicillin, resistance rates were consistently low at 0.2% ...

CLINDAMYCIN PHOSPHATEsolution CLINDAMYCIN PHOSPHATElotion CLINDAMYCIN PHOSPHATEgel [Greenstone LLC]

Updated Date: Apr 20, 2010 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>

Inducible clindamycin resistance in

Conclusion: Study showed that D test should be used as a mandatory method in routine disc diffusion testing to detect inducible clindamycin resistance. (Source: Indian Journal of Medical Microbiology)

Significance of MRSA strains in community associated skin and soft tissue infections

Shenoy M S, Bhat G K, Kishore A, Hassan M KIndian Journal of Medical Microbiology 2010 28(2):152-154The study was conducted to determine the antibiotic susceptibility profile of community-associated methicillin resistant Staphylococcus aureus (CAMRSA) strains isolated from infections. S. aureus strains were isolated from clinical specimens using the standard procedures. CDC definition was used to classify CAMRSA. Antibiotic susceptibility test was done using Kirby-Bauer disk diffusion method. Double disk diffusion method (D-test) was used to detect inducible macrolide, lincosamide and streptogramin B resistance (inducible MLS B resistance ) . A total of 83 CAMRSA were isolated from abscesses and other skin infections in persons without known risk factors for MRSA infection. All CAMRSA were...

Clindamycin-induced Sweet syndrome

We report a case of clindamycin-induced Sweet syndrome (SS). SS is the prototype of an inflammatory neutrophilic dermatoses. There are four cardinal features: fever, tender erythematous plaques, leukocytosis, and histologically dense, dermal infiltration of the skin lesions with mature neutrophils. It has been associated with infections, malignancies, inflammatory diseases, autoimmune disorders, drugs, and pregnancy. In our case, a 34-year-old male underwent a root canal and 1 week later was started on penicillin V potassium 500 mg four times daily for pain and swelling. Because of the persistence of his symptoms after 6 days, he was started on clindamycin 300 mg four times daily and the penicillin was discontinued. Three days later, the patient noted ‚??pimples‚?Ě on his scalp which progr...

The pulsed dye laser as an adjuvant treatment modality in acne vulgaris - a randomized controlled single blinded trial.

Conclusions: Our findings do not support the concept of a substantial benefit of PDL treatment in acne vulgaris. PMID: 20394631 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)

The pulsed-dye laser as an adjuvant treatment modality in acne vulgaris: a randomized controlled single-blinded trial

Conclusions Our findings do not support the concept of a substantial benefit of PDL treatment in acne vulgaris. (Source: British Journal of Dermatology)<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>

Grisel‚??s syndrome‚??a rare complication following ‚??small‚?Ě operations and infections in the ENT region

Abstract&nbsp;&nbsp;The atlanto-axial subluxation (Grisel‚??s syndrome) is a rare complication following operative procedures and/or infections in the upper aerodigestive tract. Pathogenetically the higher flexibility of the ligaments during the inflammation causes a subluxation between axis and atlas. When the inflammation heals, this can probably result in a fixation in the rotated position. The purpose of the present study was to describe the clinical and radiological characteristics of this rare disease in children. The clinical files of 12 patients with Grisel‚??s syndrome were examined retrospectively. The clinical files of these patients were reviewed and analyzed along with the results of radiographic and laboratory examinations. The clinical parameters were compared with the...

Intra- and Interlaboratory Performance of Two Commercial Antimicrobial Susceptibility Testing Methods for Bifidobacteria and Non-Enterococcal Lactic Acid Bacteria.

Authors: Huys G, D'Haene K, Cnockaert M, Tosi L, Danielsen M, Fl&#xF3;rez AB, M&#xE4;tt&#xF6; J, Axelsson L, Korhonen J, Mayrhofer S, Egerv&#xE4;rn M, Giacomini M, Vandamme P In a small-scale harmonization study involving nine laboratories in eight European countries, the intra- and interlaboratory performance of two commercially available systems, i.e. the VetMIC(TM) microplate system and Etest(R), was analyzed for antimicrobial susceptiblity testing of non-enterococcal lactic acid bacteria (NELAB) and bifidobacteria. In addition, one laboratory also performed standard broth microdilution as a reference method. MICs of tetracycline, erythromycin, ampicillin, gentamicin, clindamycin, streptomycin and (for a selection of relevant taxa) vancomycin were determined for the type strains of ...

CLINDAMYCIN PHOSPHATEaerosol, Foam [Perrigo New York Inc]

Updated Date: Apr 9, 2010 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

Combinations of maggot excretions/secretions and antibiotics are effective against Staphylococcus aureus biofilms and the bacteria derived therefrom

Conclusions Combinations of maggot ES and antibiotics eliminate S. aureus biofilms and the bacteria derived therefrom. (Source: Journal of Antimicrobial Chemotherapy)

DUAC (Clindamycin Phosphate And Benzoyl Peroxide) Gel [Stiefel Laboratories Inc]

Updated Date: Apr 6, 2010 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>

Perrigo and Partner Cobrek Launch Generic Version of Evoclin(R) and Announce Settlement of Related Litigation

ALLEGAN, Mich., April 5 (HSMN NewsFeed) -- Perrigo Company (Nasdaq: PRGO; TASE) today announced that together with its partner Cobrek Pharmaceuticals, Inc. final approval has been received from the U.S. Food and Drug Administration to manufacture and ma... Biopharmaceuticals, Generics, LitigationPerrigo, Cobrek Pharmaceuticals, Stiefel Laboratories, GSK, Clindamycin (Source: HSMN NewsFeed)

Epidemiology of methicillin-resistant Staphylococcus aureus among incarcerated population in Hawai'i, 2000-2005.

Authors: Li F, Miller FD, Effler PV It is estimated in this study the proportion and incidence of MRSA among the entire state of Hawai'i inmate population over a period of six years, using a statewide, population-based antimicrobial resistance surveillance system. Trend analyses were conducted on both MRSA proportion and MRSA incidence rates including MRSA patterns of antimicrobial resistance to other antibiotics. During the period from 2000 to 2005, 521 (69%) of 753 S. aureus isolates were MRSA. A significant increase in the proportion of MRSA were identified from both jail and prison inmates (p &lt; 0.01). A significant increase in MRSA incidence was also observed among jail inmates (p = 0.005) but not among prison inmates (p = 0.18). A majority of non-beta-lactams, including clindam...

Prevalence and molecular mechanism of macrolide resistance in ő≤-haemolytic streptococci in The Netherlands

Abstract: The prevalence of resistance to erythromycin and clindamycin as well as the presence of the resistance genes mef(A), mef(E), erm(A) and erm(B) were determined in 1076 consecutive isolates of ő≤-haemolytic streptococci of Lancefield groups A (n=219), B (n=562),C (n=58) and G (n=237) collected during 2005 and 2006. The prevalence of macrolide resistance was highest in group C streptococci (6.9%), followed by group B (5.3%), group G (4.6%) and group A (1.4%). Eighty-eight percent of resistance was mediated by erm(A) and erm(B) genes. Macrolide resistance in ő≤-haemolytic streptococci in The Netherlands is low, but increasing macrolide resistance was observed in group B streptococci. (Source: International Journal of Antimicrobial Agents)

Hospital-Acquired Pneumonia and Bacteremia Caused by Legionella pneumophila in an Immunocompromised Patient

We describe the first reported case of hospital-acquired pneumonia and bacteremia caused by L. pneumophila from Taiwan in a patient with idiopathic thrombocytopenic purpura who received steroid treatment. The patient was successfully treated with ceftazidime and clindamycin initially, followed by ciprofloxacin for 14&nbsp;days. The blood isolate was further confirmed by 16S rDNA sequence analysis. Content Type Journal ArticleCategory Case ReportDOI 10.1007/s15010-009-9253-1Authors C.-C. Lai, Cardinal-Tien Hospital Dept. of Internal Medicine Taipei TaiwanC.-K. Tan, Chi-Mei Medical Center Dept. of Intensive Care Medicine Tainan TaiwanC.-H. Chou, National Taiwan University Hospital Yun-Lin Branch Dept. of Internal Medicine Yun-Lin TaiwanH.-L. Hsu, National Taiwan University College o...

Dissipation and Leaching Potential of Selected Pharmaceutically Active Compounds in Soils Amended with Biosolids.

Authors: Wu C, Spongberg AL, Witter JD, Fang M, Czajkowski KP, Ames A Biosolids land application is an important pathway introducing pharmaceuticals into the environment. In this work, laboratory column and dissipation experiments were performed using soils of varying properties in order to study the fate and transport of pharmaceutical residues introduced by the land application of biosolids. For experimentation, five pharmaceutical compounds (carbamazepine, diphenhydramine, fluoxetine, diltiazem, and clindamycin) and two metabolites (carbamazepine-10,11-epoxide and norfluoxetine) commonly found in biosolids were selected. Leaching experiments indicate that the selected pharmaceuticals have low mobility in tested soils. However, small portions of the applied pharmaceuticals were recov...<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>

Lemierre syndrome associated with group A streptococcal infection

We report a case of Lemierre syndrome caused by group A Streptococcus (GAS) in a 4-year-old girl. She was initially diagnosed with GAS pharyngitis but failed treatment with azithromycin and subsequently developed right-sided neck swelling concerning for a deep neck abscess. A neck computed tomography scan revealed right internal jugular vein thrombosis but no abscess. Blood culture grew GAS, sensitive to penicillin and ceftriaxone but resistant to clindamycin and azithromycin. The patient was treated with ceftriaxone and anticoagulation resulting in complete recovery. Although very unusual, physicians must be aware that GAS can cause Lemierre syndrome. Penicillin should remain the drug of choice for GAS pharyngitis. Early diagnosis and treatment of Lemierre syndrome is crucial to decrease ...

Antibiotic susceptibility and resistance of the odontogenic microbiological spectrum and its clinical impact on severe deep space head and neck infections

Conclusion: The high resistance rate for clindamycin and macrolides was especially striking and may necessitate an adaptation of our antibiotic regime in the future. (Source: Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontics)

MRSA - too many hurdles to overcome: a study from Central India.

This study describes the prevalence of MRSA strains and their antibiogram in a tertiary care hospital in Central India. The detection of MRSA was done by a cefoxitin (30 microg) disc diffusion test. Antibiotic sensitivity tests were done as per the Clinical and Laboratory Standards Institute guidelines 2006. Of the 280 S. aureus strains studied: 145 (51.8%) strains were MRSA; 51 (35.2%) MRSA strains were inducible clindamycin resistant; and all (100%) MRSA strains were resistant to penicillin and sensitive to vancomycin and linezolid. In order to detect the MRSA strains, cefoxitin disc diffusion tests should be used routinely in any microbiology laboratory to enable prompt treatment for the patient. PMID: 20305109 [PubMed - in process] (Source: Tropical Doctor)

Genetic characterization and diversity of Streptococcus agalactiae isolates with macrolide resistance.

Authors: Brzychczy-Wloch M, Gosiewski T, Bodaszewska M, Pabian W, Bulanda M, Kochan P, Strus M, Heczko PB Macrolide resistance in 169 Streptococcus agalactiae (GBS) isolates originating from pregnant carriers was investigated. Using multiplex PCR the presence of genes encoding erythromycin resistance and capsular polysaccharides, as well as surface proteins were described. RAPD and PFGE were used to characterize specific clones among isolates. In the examined population of women, erythromycin resistant strains were found in 4.5% patients whereas for clindamycin in 3%, which was 16% and 10% among GBS isolates, accordingly. Among isolates the largest percentage was represented by cMLS(B) phenotype (63%), then iMLS(B) (26%) and M (11%). The ermB gene was indicated in all isolates with cML...

Activity of Ceftaroline Against Recent Emerging Serotypes of Streptococcus pneumoniae in the USA.

Authors: Jacobs MR, Good CE, Windau AR, Bajaksouzian S, Biek D, Critchley IA, Sader HS, Jones RN The in vitro activity of ceftaroline was investigated against 891 US pneumococci collected in 2008 from 22 centers. Ceftaroline was the most potent agent tested, with MICs &lt;0.008-0.5 mug/ml, and MIC90s &lt;0.008-0.25 mug/ml against 11 prevailing serotypes. Overall susceptibilities were: penicillin G, 86.2%; ceftriaxone, 90.7%; cefuroxime, 70.1%; erythromycin, 61.6%; clindamycin, 79.2%; levofloxacin, 99.4%; vancomycin, 100%. Serotype 19A was least susceptible. These results support use of ceftaroline in pneumococcal infections, including those resistant to other agents. PMID: 20308374 [PubMed - as supplied by publisher] (Source: Antimicrobial Agents and Chemotherapy)<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>

[Clinical Picture] Human cowpox in a veterinary student

A 19-year-old previously well female veterinary student with regular contact with diverse species of animals presented with an initially small red plaque on her left cheek. During the next 3 weeks the lesion developed into an ulcerated nodule 4 cm in size with a brownish eschar on top, a satellite papule, and marked inflammation of the surrounding skin (). The patient had malaise and a painful pronounced cervical lymphadenopathy. Laboratory investigations were unremarkable except for a transient elevation of C-reactive protein (820 mg/L), neutropenia (38%), and eosinophilia (11%). During 2 weeks of intravenous treatment with piperacillin and tazobactam combined first with clindamycin then doxycycline, the nodule demarcated but persisted, and a complete necrectomy was done. The resulting la...

Macrolide resistance in group A beta haemolytic Streptococcus isolated from outpatient children in Latvia

We describe high antimicrobial resistance of GAS to macrolides in outpatient children (78%), which can be explained by the frequent use of macrolides in the treatment of such individuals. Therefore, macrolides should not be the first drug of choice. (Source: APMIS)

CLEOCIN T (Clindamycin Phosphate) Solution CLEOCIN T (Clindamycin Phosphate) Lotion CLEOCIN T (Clindamycin Phosphate) Gel [Pharmacia And Upjohn Company]

Updated Date: Mar 19, 2010 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

[Case Report] Nosocomial transmission of necrotising fasciitis

In June, 2008, a previously healthy 8-month-old girl presented with chickenpox, fever (39¬∑5¬įC), and a red, painful, and swollen right arm with dusky and purplish skin discoloration (). Empirical intravenous antimicrobial therapy with amoxicillin-clavulanate and clindamycin was initiated after microbiological screening (blood culture and wound smear). A diagnosis of cellulitis with suspicion of necrotising fasciitis was made and surgical debridement was undertaken within 8 h after admission (). Macroscopic and microscopic examination confirmed extensive necrosis. A few hours later, she developed hypotension, renal failure, coagulopathy, and thrombocytopenia. Probable toxic shock syndrome was diagnosed and intensive supportive care started. Multi-susceptible group A streptococcus was isola...

Leuconostoc pseudomesenteroides blood stream infection following liver transplantation.

Conclusions: Leuconostoc spp. should be considered pathogens in transplant recipients who are exposed to vancomycin.&lt;br /&gt; &lt;br /&gt; PMID: 20305321 [PubMed - in process] (Source: Annals of Transplantation)<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>

Prospective controlled clinical and histopathologic study of hidradenitis suppurativa treated with the long-pulsed neodymium:yttrium-aluminium-garnet laser

Conclusions: Long-pulsed neodymium:yttrium-aluminium-garnet laser, together with topical benzoyl peroxide and clindamycin, is significantly more effective than topical benzoyl peroxide and clindamycin alone for the treatment of HS. Preliminary review of histopathology suggests the mechanism of action is destruction of the hair follicle. The overall success of the treatment in both clearing pre-existing lesions and preventing new eruptions, coupled with high patient satisfaction, makes the neodymium:yttrium-aluminium-garnet laser a promising treatment advance for this highly disabling condition. (Source: Journal of the American Academy of Dermatology)

Necrotizing Cerebellitis and Cerebellar Atrophy Caused by Neospora caninum Infection: Magnetic Resonance Imaging and Clinicopathologic Findings in Seven Dogs

Adult dogs with neosporosis can develop a variety of neurologic signs. No area of predilection within the nervous system so far has been identified in adult dogs. To document neosporosis as a cause of progressive cerebellar ataxia and cerebellar atrophy in dogs. Seven client-owned dogs. Retrospective, descriptive study. Age at diagnosis ranged from 1 year 6 months to 9 years 11 months. Neuroanatomic localization indicated cerebellar and brainstem disease in 6 dogs and a central vestibular lesion in 1 dog. In all 7 dogs, there was moderate to marked bilaterally symmetrical cerebellar atrophy, with the atrophied cerebellum being surrounded by a region of T2-weighted hyperintense and T1-weighted hypointense signal. Cerebrospinal fluid (CSF) analysis in all but 1 dog showed mononuclear pleocyt...

In vitro activity of tigecycline in Plasmodium falciparum culture-adapted strains and clinical isolates from Gabon

This study demonstrates the potential of tetracycline derivatives in the development of improved antimalarials. (Source: International Journal of Antimicrobial Agents)

In vitro susceptibility to antimicrobial agents and ultrastructural characteristics related to swimming motility and drug action in Campylobacterjejuni and C. coli

In this study, we examined in vitro susceptibility to 36 antimicrobial agents of 109 strains of C. jejuni and C. coli isolated from chickens and patients with enteritis or Guillain‚??Barr√© syndrome from 1996 to 2009. Among these agents, carbapenems (imipenem, meropenem, panipenem, and biapenem) showed the greatest activity [minimal inhibitory concentration (MIC)90, 0.03‚??0.125&nbsp;őľg/ml]. This was followed by sitafloxacin (MIC90, 0.25&nbsp;őľg/ml), furazolidone and azithromycin (MIC90, 0.5&nbsp;őľg/ml), gentamicin and clindamycin (MIC90, 1&nbsp;őľg/ml), and clavulanic acid (ő≤-lactamase inhibitor; MIC90, 2&nbsp;őľg/ml). All or most strains were resistant to aztreonam, sulfamethoxazole, and trimethoprim. Marked resistance was also observed for levofloxacin and tetracyclines. Resistan...

Perioperative Antibiotics in the Setting of Microvascular Free Tissue Transfer: Current Practices

J reconstr MicrosurgDOI: 10.1055/s-0030-1249606ABSTRACTMicrovascular free tissue transfer is a ubiquitous and routine method of restoring anatomic defects. There is a paucity of data regarding the role of perioperative antibiotics in free tissue transfer. We designed a survey to explore usage patterns among microvascular surgeons and thereby define a standard of care. A 24-question survey regarding the perioperative antibiotic use in microvascular head and neck, breast, and lower extremity reconstruction was sent to all those members of the American Society for Reconstructive Microsurgery who had registered e-mail addresses (&#8201;=&#8201;450). Ninety-nine members responded. A first-generation cephalosporin is the most frequent choice of perioperative antibiotics across most categories: 9...<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>

DUAC (Clindamycin Phosphate And Benzoyl Peroxide) Gel [Stiefel Laboratories Inc]

Updated Date: Mar 9, 2010 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

Antimicrobial characterisation of CEM-101 activity against respiratory tract pathogens, including multidrug-resistant pneumococcal serogroup 19A isolates

The objective of this study was to assess the activity of CEM-101 and comparators against contemporary respiratory tract infection (RTI) isolates. A worldwide sample of organisms was used, including Streptococcus pneumoniae [n=168; 59.3% erythromycin-resistant and 18 multidrug-resistant (MDR) serogroup 19A strains], Moraxella catarrhalis (n=21; 11 ő≤-lactamase positive), Haemophilus influenzae (n=100; 48 ő≤-lactamase positive), Haemophilus parainfluenzae and Haemophilus haemolyticus (n=12), and Legionella pneumophila (n=30). Testing and interpretation were performed using reference Clinical and Laboratory Standards Institute methods. CEM-101 was very potent against S. pneumoniae [minimum inhibitory concentration for 90% of the organisms (MIC90)=0.25mg/L; highest MIC at 0.5mg/L] and was 2- ...

Pattern of antibiotic prescription in the management of endodontic infections amongst Spanish oral surgeons

Conclusions The majority of the members of the SECIB were selecting the appropriate antibiotic for use in endodontic infections, but there are still many who are prescribing antibiotics inappropriately. The use of antibiotics for minor infections, or in some cases in patients without infections, could be a major contributor to the world problem of antimicrobial resistance. (Source: International Endodontic Journal)

CLINDAMYCIN HYDROCHLORIDEcapsule, Gelatin Coated [Sandoz Inc]

Updated Date: Mar 1, 2010 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

BenzaClin Bests Differin in Quality-of-Life Scores

BERLIN ‚?? Quality-of-life scores were significantly better at all time points in patients with mild to moderate acne treated with clindamycin 1% plus benzoyl peroxide 5% gel, compared with adapalene 0.1% gel. (Source: Pediatric News)<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>

Man With Painful Skin Lesion

[Ann Emerg Med. 2010;55:302.] A 53-year-old man presented with a painful skin lesion on his left lower leg, without trauma. The lesion was initially pruritic and had appeared spontaneously 2 weeks earlier. The patient had been evaluated 1 week earlier and was prescribed clindamycin for presumed cellulitis. Despite this, the lesion continued to grow. The patient had a history of peripheral vascular disease and had resumed receiving warfarin sodium for this 1 week before appearance of the lesion. On physical examination, the patient was afebrile, with a 5-cm-√?-7-cm nonraised area of ecchymosis with an erythematous border on the anterior left lower leg (). (Source: Annals of Emergency Medicine)

Blame inappropriate implementation for failure of intrapartum antibiotic prophylaxis for group B Streptococcus

In this issue of The Journal, Blaschke et al from Salt Lake City, Utah, provide the case that was bound to happen. With increasing resistance of group B Streptococcus (GBS) to erythromycin and clindamycin, and too-quick, too-easy reflex to substitute clindamycin for penicillin or ampicillin when mother has a history of penicillin ‚??allergy,‚?Ě the math was going to add up to transmission and disease due to a clindamycin-resistant GBS in a newborn. Blaschke et al provide the case‚??an ‚??old fashioned‚?Ě one‚??of severe early-onset disease in an otherwise healthy term infant, whose mother received IAP with clindamycin. (Source: The Journal of Pediatrics)

Characterization of CEM-101 Activity Against Gram-Positive Organisms.

Authors: Woosley LN, Castanheira M, Jones RN In vitro activity of CEM-101, a new fluoroketolide, was determined against Gram-positive organisms with various macrolide susceptibility profiles. Experiments for determination of MIC and MBC, timed-killing, single-step and multistep mutation rates, erythromycin induction of resistance, post-antibiotic effect (PAE) and drug interactions were performed for CEM-101 and results compared to telithromycin, macrolides and lincosamides. CEM-101 MBC results remained overall lower than those of telithromycin and CEM-101 displayed a two-fold greater potency compared the ketolide. Timed-killing curve testing resulted in CEM-101 having greater bactericidal activity than telithromycin (&gt;/=3 log10 CFU/ml decrease of initial inoculum at 24 hours) for th...

The pharmacokinetics of clindamycin in pregnant women in the peripartum period.

Authors: Muller AE, Mouton JW, Oostvogel PM, D&#xF6;rr PJ, Voskuyl RA, Dejongh J, Steegers EA, Danhof M The study was performed to describe the pharmacokinetics of intravenously administered clindamycin in pregnant women. 7 pregnant women treated with clindamycin were recruited. Maternal blood, arterial and venous umbilical cord blood samples were obtained. Maternal clindamycin concentrations were analyzed with nonlinear mixed-effects modeling using NONMEM. Data were best described by a linear three-compartment model. Clearance and volume of distribution at steady state were 10.0 L/h and 6.32 x 10(3) L. Monte Carlo simulations were performed to determine the area under concentration curve for the free (unbound) drug in maternal serum for 24 hours over the MIC (fAUC0-24h/MIC). At a MIC ...

Expanded Clinical Presentation of Community-Acquired MRSA Pneumonia.

CONCLUSION: CA-MRSA pneumonia is also not necessarily a post influenza infection. Despite necrotizing features in many, the mortality of CA-MRSA pneumonia in our series is lower than previously reported and patients do not routinely require ICU care. Treatment with antibiotics which inhibit exotoxin production and/or nontoxigenic strains may explain this improved outcome. PMID: 20173050 [PubMed - as supplied by publisher] (Source: Chest)<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>

CLINDAMYCIN PHOSPHATElotion CLINDAMYCIN PHOSPHATEsolution CLINDAMYCIN PHOSPHATEgel [E. FOUGERA CO., A Division Of Nycomed US Inc.]

Updated Date: Feb 18, 2010 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

Molecular characterization and antimicrobial susceptibility profiles in Streptococcus agalactiae colonizing strains: association of erythromycin resistance with subtype III-1 genetic clone family

Clin Microbiol Infect Knowledge of the epidemiology of Streptococcus agalactiae in Portugal is limited: therefore, the present study aimed to investigate the carriage rate of S. agalactiae among Portuguese women of reproductive age and the prevalence of antibiotic resistance, as well as to perform a molecular characterization of the clinical isolates. S. agalactiae was recovered from 6.2% of 4269 women during the period 2005[ndash]2007, with a predominance of capsular genotypes III (35%), V (33%), Ia (16%) and II (10%) in a sample of 100 isolates. To our knowledge, this is the first report of the S. agalactiae colonization rate in Portugal determined according to CDC guidelines. All isolates were susceptible to penicillin and vancomycin, whereas resistance to clindamycin and erythromycin w...

CLINDAMYCIN HYDROCHLORIDEcapsule [KAISER FOUNDATION HOSPITALS]

Updated Date: Feb 16, 2010 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

Detection of resistance genes and susceptibility patterns in Bacteroides and Parabacteroides strains.

Authors: Boente RF, Ferreira LQ, Falc&#xE3;o LS, Miranda KR, Guimar&#xE3;es PL, Santos-Filho J, Vieira JM, Barroso DE, Emond JP, Ferreira EO, Paula GR, Domingues RM Susceptibility to five antimicrobials was determined for Bacteroides spp. (n= 52) and Parabacteroides distasonis (n= 8). All isolates were susceptible to metronidazole. The resistance rates to ampicillin, cefoxitin, tetracycline and clindamycin were 98%, 9.6%, 65.3% and 19.2% of the Bacteroides strains, respectively. The genes cepA, cfiA, cfxA, tetQ, ermF and nim were found in 69.2%, 17.3% 9.6%, 50%, 7.7% and 3.8% for these strains respectively. All P. distasonis strains were resistant to ampicilin. Cefoxitin, tetracycline and clindamycin resistance rates were 75%, 87.5% and 50%, respectively. The ermF and nim genes were ab...

CLINDAMYCIN HYDROCHLORIDEcapsule [Greenstone LLC]

Updated Date: Feb 12, 2010 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>

CLINDAMYCIN HYDROCHLORIDEcapsule [Stat Rx USA]

Updated Date: Feb 12, 2010 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

CLINTABS (Clindamycin Hydrochloride) Tablet [Virbac AH, Inc.]

Updated Date: Feb 12, 2010 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

CLEOCIN HYDROCHLORIDE (Clindamycin Hydrochloride) Capsule [Pharmacia And Upjohn Company]

Updated Date: Feb 12, 2010 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

CLINSOL (Clindamycin Hydrochloride) Liquid [Virbac AH, Inc.]

Updated Date: Feb 12, 2010 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

Risk factors for development of C.difficile-associated diarrhoea following prophylactic antibiotics for surgical infections

Source: Ann Surg Area: News It is well known that multiple antibiotics contribute to the development of Clostridium difficile-associated diarrhoea (CDAD); however the role of preventive antibiotics is unproven. &nbsp; To further investigate, researchers prospectively reviewed an 11-year (December 1996 and September 2007) dataset of consecutive infections treated in surgical patients at a single hospital in Virginia. All intra-abdominal, surgical site, or skin/skin structure infections were identified. Each infection was evaluated for antibiotic coverage (metronidazole, penicillins, ureidopenicillins, cephalosporins, carbapenems, aminoglycosides, fluoroquinolones, and clindamycin) and subsequent CDAD. &nbsp; The following findings were noted: .&nbsp;A total of 4178 infections wer...<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>

Epidemiology of invasive Streptococcus pyogenes&nbsp; disease in Germany during 2003&#x2013;2007

A nationwide laboratory-based surveillance study of invasive Streptococcus pyogenes infections was conducted in Germany. Invasive isolates (n=586) were obtained between 2003 and 2007. Most isolates were obtained from blood (53.9%) or skin lesions (17.6%). The most common emm types were emm 1 (30.5%), emm 28 (18.3%) and emm 3 (9.6%). Overall, speA was positive in 45.9%, speC in 44.7% and ssa in 14.8% of isolates. SpeA was common in emm type 1 (100%) and emm type 3 (96.4%), whereas speC was often observed in emm type 28 (93.5%). The most frequent clinical manifestations included sepsis (40.1%), necrotizing fasciitis (20.8%) and streptococcal toxic shock syndrome (16.6%). All isolates were susceptible to penicillin G, cefotaxime and levofloxacin. Tetracycline shows the highest rate of resista...

Antibiotic Susceptibility of Bifidobacterial Strains Distributed in the Japanese Market.

Authors: Xiao JZ, Takahashi S, Odamaki T, Yaeshima T, Iwatsuki K The aim of the present study was to analyze the antibiotic susceptibility of bifidobacterial strains distributed in the Japanese market. A total of 23 strains, including probiotic isolates from foods, supplements, pharmaceuticals and reference strains of each species (or subspecies), were tested for susceptibility to 15 antibiotics by the broth microdilution method and examined for the presence of possible resistant determinants. The strains were susceptible overall to chloramphenicol, ampicillin, vancomycin and linezolid, and were intrinsically resistant to aminoglycoside group agents. Susceptibility to erythromycin, clindamycin, rifampicin, tetracycline and trimethoprim varied among the strains. All strains of Bifidobac...

CLINDAMYCIN PHOSPHATEaerosol, Foam [Perrigo New York Inc]

Updated Date: Feb 2, 2010 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

Epidemiological markers of Streptococcus pyogenes strains in Tunisia

Clin Microbiol Infect To further understand the epidemiology of Streptococcus pyogenes or group A streptococcus (GAS) infections in Tunisia, phenotypic and genomic markers of GAS isolates, including antibiotic susceptibility, biotypes, T and emm types and toxin gene profiles, have been characterized. A total of 103 isolates, collected between 2000 and 2006, were investigated; 47 were recovered from invasive infections, and 56 from non-invasive infections. Rates of tesistance to tetracycline, erythromycin, clindamycin and rifampin were 70.8%, 4.8%, 4.8% and 0.9%, respectively. High levels of resistance to streptomycin and kanamycin were observed in 1.9% and 4.8% of isolates, respectively. Biotype 3 was most common. Twenty different T patterns were observed, with a predominance of T3/13/B326...

Staggered Sensitivity Results

A 60-year-old woman with squamous cell carcinoma of the glottis underwent laryngectomy, anterior neck dissection, and pectoralis flap reconstruction of the anterior esophagus. Postoperatively, she was started on clindamycin for surgical site infection prophylaxis. On postoperative day three, increased drainage from the surgical site was noted. On postoperative day six, the patient had to return to the OR for exploration, and the site revealed purulent material with involvement of the jugular sheath. The surgeon cultured, irrigated, and reclosed the site. (Source: AORN Journal)<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>

BenzaClin Earns Higher Scores Than Differin for Acne Therapy

BERLIN ‚?? Quality-of-life scores were significantly better at all time points in patients with mild to moderate acne treated with clindamycin 1% plus benzoyl peroxide 5% gel, when compared with adapalene 0.1% gel. (Source: Internal Medicine News)

[Antimicrobial Susceptibility Patterns of Legionella isolates in the Environment and in Patients.]

CONCLUSIONS: Legionella spp. isolates from Korea and Japan were most susceptible to gatifloxacin. Azithromycin, clarithromycin, ciprofloxacin, and gemifloxacin were also effective for treating legionellosis. PMID: 20197719 [PubMed - in process] (Source: The Korean Journal of Laboratory Medicine)

Prevalence of phenotypic resistance of Staphylococcus aureus isolates to macrolide, lincosamide, streptogramin B, ketolid and linezolid antibiotics in Turkey.

In conclusions, the prevalence of cMLS B was predominant in MRSA; while in MSSA strains, iMLS B and M/MS B phenotype were more higher than cMLS B phenotype resistance. The resistance to quinupristindalfopristin was very low, and linezolid was considered as the most effective antibiotic against all S.aureus strains. PMID: 20428647 [PubMed - in process] (Source: Braz J Infect Dis)

Daily compared with 8-hour gentamicin for the treatment of intrapartum chorioamnionitis: a randomized controlled trial.

CONCLUSION:: Daily and 8-hour gentamicin appear equally effective for the treatment of intrapartum chorioamnionitis. CLINICAL TRIAL REGISTRATION:: ClinicalTrials.gov, www.clinicaltrials.gov, NCT00185991. LEVEL OF EVIDENCE:: I. PMID: 20093909 [PubMed - in process] (Source: Obstetrics and Gynecology)

Clindamycin hydrochloride monohydrate and its ethanol solvate

Clindamycin hydrochloride, an antibiotic of the lincomycin family, was crystallized as the monohydrate, namely (2S,4R)-2-(N-{(1S,2S)-2-chloro-1-[(3R,4S,5R,6R)-3,4,5-trihydroxy-6-(methylsulfanyl)perhydropyran-2-yl]propyl}aminocarbonyl)-4-propylpyrrolidinium chloride monohydrate, C18H34ClN2O5S+¬∑Cl‚??¬∑H2O, (I), and as the monohydrate ethanol solvate, C18H34ClN2O5S+¬∑Cl‚??¬∑H2O¬∑C2H6O, (II). The conformation of the clindamycin molecule in both crystal structures is the same and is found to be similar to that in enzyme-bound clindamycin. The simultaneous presence of free chloride ions and water molecules in (I) and of additional ethanol molecules in (II) provides an interesting network of hydrogen bonds. The significance of this study lies in the interactions in these structures and the aggre...<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>

Tooth Decay

An ER physician 110 miles away, calling the OMS on call on the STAT transfer line: ‚??This young boy came to the ER two days ago with a toothache and minimal swelling. He was placed on Clindamycin and his parents were instructed to take him to see a dentist. His parents did not have the money for that visit so it did not happen. He now returns with trismus, difficulty swallowing, change in voice, inability to handle secretions, white count of 25 K, and temp of 39¬ļ C. CT scan shows an impending Ludwig's angina. Oh, and we do not have an oral and maxillofacial surgeon here on call and our surgeon says it is out of his area of expertise.‚?Ě‚??It sounds like he is too sick to transport by ground. We'll call for helicopter transport. Forward the CT electronically into PACS,‚?Ě came the reply. ...

Clindamycin: Acute hepatotoxicity: case report

(Source: Reactions)

A patient with Lemierre syndrome

We present the case of a previously healthy 12-year-old boy with Lemierre syndrome, caused by streptococci (Abiotrophia defectiva), complicating a subcutaneous neck abscess. The patient had metastatic sequelae, was treated with antibiotics (clindamycin and vancomycin) and low molecular weight heparin, and had an uneventful outcome. Content Type Journal ArticleCategory Short ReportDOI 10.1007/s00431-009-1134-6Authors Efthimia G. Vargiami, Aristotle University of Thessaloniki 1st Pediatric Clinic Dorilaiou 3, Kalamaria Thessaloniki 55133 GreeceE. Farmaki, Aristotle University of Thessaloniki 1st Pediatric Clinic Dorilaiou 3, Kalamaria Thessaloniki 55133 GreeceD. Tasiopoulou, Aristotle University of Thessaloniki 1st Pediatric Clinic Dorilaiou 3, Kalamaria Thessaloniki 55133 GreeceD. I. ...

Lung abscess and pleuritis caused by Lactobacillus rhamnosus in an immunocompetent patient

Abstract&nbsp;&nbsp;A 79-year-old man consulted us because of left chest pain and fever ranging from 38.0 to 38.9¬įC. A chest computed tomography scan showed a mass lesion (Ō?40&nbsp;mm) in the left lingular segment, and inflammatory markers were elevated. He was admitted with a diagnosis of lung abscess, and panipenem/betamipron was administered at a dose of 2&nbsp;g/day, after which the symptoms showed slight transient resolution. However, his body temperature increased again, to more than 39.0¬įC, on the eighth day of hospitalization, and a chest radiograph suggested pleuritis as a complication. The antibiotics were changed to teicoplanin (TEIC; 400&nbsp;mg/day) and meropenem (2.0&nbsp;g/day). Thoracic drainage and pleural lavage were initiated at the same time. Lactobacillus spp. ...

Cleocin (Clindamycin) - updated on RxList

Cleocin (Clindamycin) drug description - FDA approved labeling for prescription drugs and medications at RxList (Source: RxList - New and Updated Drug Monographs)<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>

CLEOCIN PEDIATRIC (Clindamycin Palmitate Hydrochloride) Granule, For Solution [Pharmacia And Upjohn Company ]

Updated Date: Jan 11, 2010 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

Clindamycin-Resistant Group B Streptococcus and Failure of Intrapartum Prophylaxis to Prevent Early-Onset Disease

We report a case of clindamycin-resistant GBS disease in a newborn infant whose mother received clindamycin IAP, and we review clindamycin susceptibility testing. (Source: The Journal of Pediatrics)

Clinical and Economic Impact of Methicillin‚?źResistant Staphylococcus aureus Colonization or Infection on Neonates in Intensive Care Units¬†‚?Ę‚??

Conclusions.‚??MRSA colonization or infection in infants is associated with significant morbidity and financial burden but is not independently associated with increased mortality. (Source: Infect Control Hosp Epidemiol Latest Issue)

Hospital‚?źAcquired Staphylococcus aureus Infections at Texas Children‚??s Hospital, 2001‚??2007¬†‚?Ę‚??

Conclusions.‚??In our patient population, the annual numbers of observed cases of hospital‚?źacquired S. aureus infection have remained constant. USA300 was the most common clone and, compared with other non‚?źUSA300 MRSA isolates, was associated with skin and soft tissue infection, early onset of infection after admission, and greater susceptibility to antimicrobial agents. (Source: Infect Control Hosp Epidemiol Latest Issue)

Emergence of Resistance to Azithromycin‚?źAtovaquone in Immunocompromised Patients with Babesia microti Infection

Conclusions.‚??B. microti may become resistant to azithromycin‚?źatovaquone during the treatment of babesiosis with this combined drug regimen in highly immunocompromised patients. Although research is needed to determine the optimal therapy for highly immunocompromised patients with babesiosis, reducing the level of immunosuppression when possible would appear to be a desirable strategy. (Source: Clinical Infectious Diseases Latest Issue)<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>

Evaluation and comparison of the antimicrobial efficacy of teicoplanin- and clindamycin-coated titanium implants: AN EXPERIMENTAL STUDY.

Authors: Aykut S, Ozt&#xFC;rk A, Ozkan Y, Yanik K, Ilman AA, Ozdemir RM We studied the effects of coating titanium implants with teicoplanin and clindamycin in 30 New Zealand White rabbits which were randomly assigned to three groups. The intramedullary canal of the left tibia of each rabbit was inoculated with 500 colony forming units of Staphylococcus aureus. Teicoplanin-coated implants were implanted into rabbits in group 1, clindamycin-coated implants into rabbits in group 2, and uncoated implants into those in group 3. All the rabbits were killed one week later. The implants were removed and cultured together with pieces of tibial bone and wound swabs. The rate of colonisation of the organisms in the three groups was compared. Organisms were cultured from no rabbits in group 1, on...

Evaluation of the Antibacterial Activity of Rhapontigenin Produced from Rhapontin by Biotransformation against Propionibacterium acnes.

Authors: Kim JK, Kim N, Lim YH Biotransformation is often used to improve chemical activity. We evaluated the antimicrobial activity of rhapontigenin, converted from rhapontin after treatment with Pectinex. Rhapontigenin showed 4-16 times higher antimicrobial activity than rhapontin. Activity was higher against Gram positive strains than Gram negative strains. Minimum inhibitory concentrations (MICs) of rhapontigenin, retinol, and five antibiotics were determined by microbroth dilution method for antibiotic-sensitive and -resistant Propionibacterium acnes. We also investigated the in vitro antibacterial activity of rhapontigenin in combination with antibiotic against antibiotic-resistant P. acnes. The antibiotic combination effect against resistant P. acnes was studied by checkerboard ...

CLINDESSE (Clindamycin Phosphate) Cream [Ther-Rx Corporation]

Updated Date: Dec 23, 2009 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

CLINDAMYCIN PHOSPHATE AND BENZOYL PEROXIDEkit [Mylan Pharmaceuticals Inc.]

Updated Date: Dec 18, 2009 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

Onset Therapeutics Announces Results Of BenzEFoam‚?Ę Skin Hydration Study

Onset Therapeutics, a specialty pharmaceutical company focused in dermatology, today announced positive results from a skin moisturization study that compared the Company's recently launched BenzEFoam‚?Ę (benzoyl peroxide 5.3%) Emollient Foam to a market leading combination gel containing clindamycin 1% - benzoyl peroxide 5%. BenzEFoam‚?Ę Emollient Foam is indicated for the topical treatment of mild to moderate acne vulgaris and is the first prescription foam formulation containing benzoyl peroxide as the active ingredient... (Source: Health News from Medical News Today)<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>

Clindamycin: Vasculitis in elderly patients: 2 case reports

(Source: Reactions)

CLINDAMYCIN (Clindamycin Phosphate) Injection, Solution [APP Pharmaceuticals, LLC]

Updated Date: Dec 15, 2009 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

Clinical and Economic Impact of Methicillin‚?źResistant Staphylococcus aureus Colonization or Infection on Neonates in Intensive Care Units

Conclusions.‚??MRSA colonization or infection in infants is associated with significant morbidity and financial burden but is not independently associated with increased mortality. (Source: Infect Control Hosp Epidemiol Latest Issue)<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>

CLINDAMYCIN (Clindamycin Phosphate) Injection, Solution [APP Pharmaceuticals, LLC]

Updated Date: Dec 14, 2009 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

Hospital‚?źAcquired Staphylococcus aureus Infections at Texas Children‚??s Hospital, 2001‚??2007

Conclusions.‚??In our patient population, the annual numbers of observed cases of hospital‚?źacquired S. aureus infection have remained constant. USA300 was the most common clone and, compared with other non‚?źUSA300 MRSA isolates, was associated with skin and soft tissue infection, early onset of infection after admission, and greater susceptibility to antimicrobial agents. (Source: Infect Control Hosp Epidemiol Latest Issue)

Which drug is effective and safe for acute malaria in pregnancy? Reviewing the evidence

During pregnancy, a woman living or travelling in a malaria endemic area is more at risk of contracting the disease and developing a severe infection and dying than a non-pregnant woman. Despite this increased morbidity and mortality in pregnancy, there are almost no studies on which to base recommendations on the use of antimalarial drugs in this vulnerable group. This is because, paradoxically, the emphasis is often put on the safety of the unborn child rather than that of the infested mother. As a result of this neglect, tens of thousands of pregnant women (and their fetuses) are dying every year of a very preventable and treatable infection. In recent years, some trials have been conducted, especially in areas of high resistance in Plasmodium falciparum in South East Asia. The results ...

Cleocin HCl (Clindamycin Hydrochloride Capsules) - updated on RxList

Cleocin HCl (Clindamycin Hydrochloride Capsules) drug description - FDA approved labeling for prescription drugs and medications at RxList (Source: RxList - New and Updated Drug Monographs)

PICOMM-Issue 52

Inducible clindamycin resistance in Staphylococcus aureus: A study from North India Journal of Postgraduate Medicine V Gupta, P Datta, H Rani, J Chander Original Article: Background : The resistance to antimicrobial agents among Staphylococci is an increasing problem. The resistance to macrolide can be mediated by msr A gene coding for efflux mechanism or via erm gene encoding [...] (Source: Podiatry Internet Communications)<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>

False Serologic Evidence for Acute Primary Toxoplasmosis During Liver Transplantation for Fulminant Hepatitis B: A Case Report

We describe the case of a 25-year-old woman who received a liver transplantation for life-threatening liver failure due to hepatitis B virus infection. The presence of high IgM titers against T. gondii, as detected by membrane immunoassay, immunofluorescence, and őľ-capture ELISA tests, together with the absence of IgG antibodies in the immediate pretransplant serology screening suggested acute primary T. gondii infection at the time of transplantation. We initiated a preemptive therapy with intravenous clindamycin and cotrimoxazole. However, negative PCR and IgA capture assays, together with the absence of a sustained IgG response finally excluded the initial diagnosis of primary toxoplasmosis, leading to discontinuation of antitoxoplasmosis therapy. This case illustrates the problem that...

In‚?źVitro Activities of Tetracyclines, Macrolides, Fluoroquinolones and Clindamycin against Mycoplasma hominis and Ureaplasma ssp. isolated in Germany over 20 years

(Source: Clinical Microbiology and Infection)

Toxoplasmosis

Abstract: Toxoplasma gondii is a worldwide zoonotic infection. The sexual cycle occurs only in the cat family: only the cat's faeces are infectious; but cysts in animals and birds can cause infection when these are consumed. Acquired acute toxoplasma infection can be asymptomatic or have nonspecific flu-like symptoms. Lymphadenopathy is the most recognized presentation and may last more than six months. Retinochoroiditis is usually a result of reactivated congenital infection. Increasingly recognized is chronic infection producing a chronic fatigue syndrome. Reactivated infections, especially in the immunocompromised, are a major problem and prophylaxis is sometimes required. Toxoplasma status should also be determined before transplantation. Current infection is diagnosed by a high or fou...

The influence of antibiotics on the changing epidemiology of Clostridium difficile.

Authors: Taori SK, Hall V, Poxton I An increase in incidence of clinical cases of Clostridium difficile infection has been reported in recent years but few studies have examined the changes in molecular epidemiology and antibiotic resistance over a long period of time. A collection of 179 isolates of C. difficile obtained from symptomatic adult patients in southern Scotland between 1979 and 2004 was used to determine changes in the prevalence of epidemiological types and antibiotic susceptibilities to common antibiotics. PCR ribotyping and MICs were performed on all isolates. A total of 56 different ribotypes was identified among which ribotype 002 was the commonest type overall (14%), followed by ribotypes 014 (7.3%), 012 (5%), 015 (5%), 020(5%), and 001 (4.5%). Ribotype 078 was also ...

Reporting clinical trials: Why one plus one does not equal two

To the Editor: We read with interest Thiboutot et al's November 2008 report of safety and efficacy of a product containing clindamycin phosphate 1.2% and benzoyl peroxide 2.5% for treatment of acne. In the report, Thiboutot et al present combined data from two randomized controlled trials (RCTs) as if the two RCTs were in fact one large RCT. Unfortunately, such an approach is invalid. (Source: Journal of the American Academy of Dermatology)<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>

Linezolid surveillance program results for 2008 (LEADER Program for 2008)

In conclusion, linezolid activity sampled by the 5th year of this LEADER Program showed sustained potency and spectrum (99.64% susceptibility levels). The nonsusceptible strain isolation rates remained stable and the plasmid-mediated ribosomal-based resistance mechanism that emerged in Staphylococcus aureus and Staphylococcus epidermidis strains in 2007 showed no evidence of dissemination or increased prevalence. However, there was evidence of cfr persistence with the S. epidermidis strain. The LEADER Program continues to be an effective and sensitive surveillance tool to detect and monitor novel oxazolidinone resistance phenotypes and genotypes. (Source: Diagnostic Microbiology and Infectious Disease)

Zyvox¬ģ Annual Appraisal of Potency and Spectrum program: linezolid surveillance program results for 2008

In conclusion, the activity of linezolid remained uniform and stable across the sampled geographic regions studied when compared to the 2006 to 2007 results. Documented LZD-R remains rare (only 0.13% overall but highest for CoNS [0.41%] and enterococci [0.69%]) among the 24 countries sampled for the 6 different pathogen groups. Rates of clindamycin resistance and the frequency of MRSA varied by geographic region and between nations; therefore, like oxazolidinones, it requires continued surveillance for changing resistance patterns. (Source: Diagnostic Microbiology and Infectious Disease)

Molecular Epidemiology and Antimicrobial Resistance Mechanisms of Methicillin-Resistant Staphylococcus aureus Isolated from Bovine Milk

The aim of this study was to identify methicillin-resistant Staphylococcus aureus (MRSA) strains gathered from 2002 to 2006 from milk samples in Aydin region in Turkey. Among 93 S. aureus strains isolated from bovine milk with mastitis, 16 were resistant to methicillin. Methicillin-resistant S. aureus strains were studied further for their staphylococcal cassette chromosome mec (SCCmec) types, pulsotypes, spa and MLST types, antimicrobial susceptibilities, mechanisms of resistance and presence of Panton[ndash]Valentine leucocidin (PVL) toxin gene. The MRSA strains were multi-drug resistant. The susceptibility rates to antimicrobials tested were 0%, 0%, 0%, 0%, 6.25%, 16.25% and 56.25% for erythromycin, clindamycin, chloramphenicol, gentamicin, tetracyclin, ciprofloxacin and vancomycin, res...

Determination of the mutant selection window for clindamycin, doxycycline, linezolid, moxifloxacin and trimethoprim/sulfamethoxazole against community-associated meticillin-resistant Staphylococcus aureus (MRSA)

In this study, mutant prevention concentration (MPC) testing was used to investigate the propensity for future resistance induction in CA-MRSA by clindamycin, doxycycline, linezolid, moxifloxacin and trimethoprim/sulfamethoxazole. Four CA-MRSA isolates [two each of clones USA300 (10841 and NRS384) and USA400 (2833 and NRS123)] were tested as well as a single hospital-acquired strain (NRS385). A variable hierarchy of the tested antimicrobials with respect to the percentage of the dosage interval that concentrations fall within the mutant selection window (%TMSW) was determined, with all antimicrobials achieving %TMSW values >20%. Against the hospital-acquired strain, all antimicrobials except linezolid (%TMSW=74.10%) and moxifloxacin (%TMSW=21.65%) are predicted to attain concentrations bel...

A variant of the Southern German clone of methicillin-resistant Staphylococcus aureus is predominant in Croatia

Clin Microbiol Infect The aim of the present study was to investigate the antibiotic susceptibility patterns and molecular epidemiology of clinical methicillin-resistant Staphylococcus aureus (MRSA) isolates recovered in 24 hospitals in 20 cities in Croatia from October to December 2004. A total of 1815 consecutive S. aureus isolates were recovered, 248 of which were MRSA. The MRSA isolates were analysed using spa typing, multilocus sequence typing and SCCmec typing. Furthermore, the presence of Panton[ndash]Valentine leukocidin (PVL) genes was determined as a genetic marker for community-associated MRSA. The MRSA prevalence was 14%. Ninety-six per cent of the MRSA isolates were resistant to ciprofloxacin, 95% to clindamycin and azithromycin, 94% to gentamicin, and 93% to erythromycin. The...<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>

Clinical efficacy of first- and second-line treatments for HIV-associated Pneumocystis jirovecii pneumonia: a tri-centre cohort study

Conclusions Pentamidine was associated with a greater risk of death when used as first- and second-line therapy for HIV-associated PCP, and was associated with more treatment changes. Clindamycin/primaquine appeared superior to pentamidine as second-line therapy for PCP in patients failing or developing toxicity with trimethoprim/sulfamethoxazole. In patients failing first-line treatment with non-trimethoprim/sulfamethoxazole regimens, second-line therapy should be trimethoprim/sulfamethoxazole. (Source: Journal of Antimicrobial Chemotherapy)

A fatal case of transfusion-transmitted babesiosis in the State of Delaware.

CONCLUSIONS: We believe that this is the first reported case of transfusion-transmitted babesiosis in Delaware, a nonendemic state. Our case illustrates that clinicians should consider babesiosis in the differential diagnosis of immunocompromised patients who have fever and recent transfusion history, even in areas where babesiosis is not endemic. It also demonstrates the need for better preventive strategies including more sensitive, specific, and rapid blood donor screening tests to prevent transfusion-transmitted babesiosis. PMID: 19906041 [PubMed - as supplied by publisher] (Source: Transfusion)

Twenty-five year epidemiology of invasive methicillin-resistant Staphylococcus aureus (MRSA) isolates recovered at a burn center

In this study we, evaluate the changes in PFT and antimicrobial resistance epidemiology of invasive MRSA isolates over 25 years at a single burn unit. Isolates were tested by pulsed-field gel electrophoresis (PFGE), broth microdilution antimicrobial susceptibility testing, and PCR for the virulence factors Panton‚??Valentine leukocidin (PVL) and arginine catabolic mobile element (ACME), and the resistance marker staphylococcal chromosomal cassette mec (SCCmec). Forty isolates were screened, revealing stable vancomycin susceptibility MIC without changes over time but decreasing susceptibility to clindamycin and ciprofloxacin. The majority of PFGE types were MRSA USA800 carrying the SCCmec I element and USA100 carrying the SCCmec II element. No strains typically associated with community-ass...

CLINDAMAX (Clindamycin Phosphate) Cream [PHARMADERM. A Division Of Nycomed US Inc.]

Updated Date: Nov 6, 2009 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

Inducible clindamycin resistance in

Conclusions : Clindamycin is kept as a reserve drug and is usually advocated in severe MRSA infections depending upon the antimicrobial susceptibility results. We have reported a higher incidence of iMLS B from both community (66.67&#x0025;) as well as hospital (33.33&#x0025;) setup. Therefore clinical microbiology laboratory should report inducible clindamycin resistance routinely. (Source: Journal of Postgraduate Medicine)<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>

CLINDAMYCIN PHOSPHATEaerosol, Foam [Perrigo New York Inc]

Updated Date: Nov 2, 2009 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

In vitro activity of cem-101 against streptococcus pneumoniae and streptococcus pyogenes with defined macrolide resistance mechanisms.

IN VITRO ACTIVITY OF CEM-101 AGAINST STREPTOCOCCUS PNEUMONIAE AND STREPTOCOCCUS PYOGENES WITH DEFINED MACROLIDE RESISTANCE MECHANISMS. Antimicrob Agents Chemother. 2009 Nov 2; Authors: McGhee P, Clark C, Kosowska-Shick K, Nagai K, Dewasse B, Beachel L, Appelbaum PC CEM-101 had an MIC range against macrolide-susceptible pneumococci of 0.002-0.016 mug/ml and of 0.004-1 mug/ml against macrolide-resistant phenotypes. Only 3 strains with erm(B) +/- mef(A) had CEM-101 MICs of 1 mug/ml and 218/221 strains had CEM-101 MICs &lt;/=0.5 mug/ml. CEM-101 MICs were up to 4-fold lower than those of telithromycin against all strains. Against Streptococcus pyogenes, CEM-101 MICs ranged between 0.008-0.03 mug/ml against macrolide-susceptible, and 0.015-1 mug/ml against -resistant strains. Against...

Propionibacterium acnes infection after shoulder arthroplasty: A diagnostic challenge

This study reviewed a series of patients diagnosed with Propionibacterium acnes infection after shoulder arthroplasty in order to describe its clinical presentation, the means of diagnosis, and provide options for treatment.Materials and methods: From 2002 to 2006, 11 patients diagnosed with P acnes infection after shoulder arthroplasty were retrospectively reviewed and analyzed for (1) clinical diagnosis; (2) laboratory data, including white blood cell count, erythrocyte sedimentation rate (ESR), and C-reactive protein (CRP); (3) fever; (4) number of days for laboratory growth of P acnes; (5) organism sensitivities; (6) antibiotic regimen and length of treatment; and (7) surgical management. Infection was diagnosed by 2 positive cultures.Results: Five patients had an initial diagnosis of ...

Pneumocystis pneumonia in children

Summary: Pneumocystis pneumonia (PCP) is a life-threatening infection in immunocompromised children with quantitative and qualitative defects in T lymphocytes. At risk are children with lymphoid malignancies, HIV infection, corticosteroid therapy, transplantation and primary immunodeficiency states. Diagnosis is established through direct examination or polymerase chain reaction (PCR) from respiratory secretions. Trimethoprim‚??sulphamethoxazole is used for initial therapy in most patients, while pentamidine, atovaquone, clindamycin plus primaquine, and dapsone plus trimethoprim are alternatives. Prophylaxis of high-risk patients reduces but does not eliminate the risk of PCP. Improved understanding of the pathogenesis of PCP is important for future advances against this life-threatening i...

Detection of new mutations conferring resistance to linezolid in glycopeptide-intermediate susceptibility Staphylococcus hominis subspecies hominis circulating in an intensive care unit

This report alerts to the possible appearance of clinical strains of methicillin-resistant staphylococci with intermediate resistance to glycopeptides, resistance to linezolid, and multiple resistance to other second-line antibiotics. Content Type Journal ArticleCategory ArticleDOI 10.1007/s10096-009-0823-4Authors A. Sorlozano, University of Granada Departamento de Microbiologia, Facultad de Medicina Avda de Madrid 11 18012 Granada SpainJ. Gutierrez, University of Granada Departamento de Microbiologia, Facultad de Medicina Avda de Madrid 11 18012 Granada SpainT. Martinez, San Cecilio University Hospital Service of Microbiology Granada SpainM. E. Yuste, San Cecilio University Hospital Intensive Care Unit Granada SpainJ. A. Perez-Lopez, San Cecilio University Hospital Service of Microb...<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>

CLEOCIN PEDIATRIC (Clindamycin Palmitate Hydrochloride) Granule, For Solution [Pharmacia And Upjohn Company ]

Updated Date: Oct 27, 2009 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

Prevalence of serotypes and antimicrobial resistance of invasive strains of pneumococcus in children: analysis of 9 years.

CONCLUSIONS: Penicillin resistance was detected in 9.9% of the strains, being predominant from 2004 to 2008. Twenty different pneumococcal serotypes were identified, and 71.9% of the serotypes were represented in the 7-valent conjugate vaccine (PN CRM7) currently available. PMID: 19859623 [PubMed - as supplied by publisher] (Source: Jornal de Pediatria)

Clindamycin-primaquine versus pentamidine for the second-line treatment of pneumocystis pneumonia

Abstract&nbsp;&nbsp;There are limited data on the efficacy of alternative regimens for treating patients with pneumocystis pneumonia (PCP). We compared the efficacy of clindamycin-primaquine (C-P) with that of pentamidine as a secondline treatment for PCP. Among 91 patients receiving trimethoprim-sulfamethoxazole (TMP-SMX) as a first-line treatment for PCP, 31 (34%) did not respond and 7 (8%) had adverse reactions. Fourteen patients received C-P and 9 received pentamidine as a second-line regimen because of treatment failure or an adverse reaction to TMP-SMX. The response rate of patients to C-P was higher than the response rate to pentamidine (9/14; 64% vs 1/9; 11%; P = 0.03). Content Type Journal ArticleCategory NoteDOI 10.1007/s10156-009-0710-zAuthors Tark Kim, Asan Medical Ce...

Management of acne vulgaris: an evidence-based update

This review summarizes clinically important findings from 3 systematic reviews, 1 updated guideline and a selection from the 62 randomized controlled trials (RCTs) published between February 2007 and January 2009 on the topic of acne vulgaris. Low glycaemic-load diets might reduce acne severity but this remains unproven. Written patient information leaflets have not been surpassed by other communication methods. New combination topical treatments have not shown convincing advantages over current combination products such as clindamycin/benzoyl peroxide. Topical dapsone is superior to placebo but has yet to be compared with standard topical treatments. Long-term topical tretinoin to prevent nonmelanoma skin cancer in elderly men was associated with higher all-cause mortality, but there is c...

Second-line salvage treatment of AIDS-associated Pneumocystis jirovecii pneumonia: a case series and systematic review

Source: DARE Area: Evidence > Disease Focused Reviews CRD Summary: The authors concluded that trimethoprim-sulfamethoxazole should be used as second-line treatment for patients with AIDS-associated Pneumocystis jirovecii pneumonia who fail first-line treatment with other regimens. The limited search, incomplete reporting of review methods, differences between studies and lack of direct comparisons between treatments meant that the authors' conclusions may not be reliable. [For second-line treatment most studies used pentamidine; other studies used trimethoprim-sulfamethoxazole (TMP-SMX), clindamycin-primaquine (C-P), or atovaquone.] CRD Commentary: The review question was clearly stated. Inclusion criteria were defined for intervention, participants, outcomes and study design. Althoug...<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>

CLINDAMYCIN PHOSPHATEcream [E. FOUGERA CO. A Division Of Nycomed US Inc.]

Updated Date: Oct 20, 2009 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

Perrigo Announces Dismissal of Duac(R) Patent Litigation

ALLEGAN, Mich., Oct. 19 (HSMN NewsFeed) -- Perrigo Company (Nasdaq: PRGO; TASE) announced today that the Hatch-Waxman litigation relating to Duac&reg; Gel (clindamycin phosphate (1%) and benzoyl peroxide (5%) gel) filed by the Stiefel Laboratories divisi... Biopharmaceuticals, Generics, LitigationPerrigo, GlaxoSmithKline, Duac , clindamycin (Source: HSMN NewsFeed)

Acenocoumarol/clindamycin interaction: First report of an interaction, leading to spontaneous haematoma in an elderly patient: case report

(Source: Reactions)

Continuous Clindamycin Infusion: an Innovative Approach to Treating Bone and Joint Infection.

Authors: Zeller V, Dzeing-Ella A, Kitzis MD, Ziza JM, Mamoudy P, Desplaces N Feasibility, safety and efficacy of prolonged, continuous, intravenous clindamycin therapy were retrospectively evaluated for 70 patients treated for bone and joint infections, 40% as outpatients. Median treatment duration was 40 days, median daily clindamycin dose was 2400 mg and 3 moderate-grade adverse events occurred. Median serum clindamycin concentrations on days 3-14 and 8-28 were 5 and 6.2 mg/liter, respectively; the median concentration was significantly lower (P&lt;0.02) in patients treated with rifampin (5.3 mg/liter) versus without rifampin (8.9 mg/liter). Among 53 patients with a median [range] follow-up of 30 [24-53] months, 49 (92%) were considered cured (1 relapse, 3 reinfections). PMID: 19...

In vitro activity of mirincamycin (U24729A) in Plasmodium falciparum isolates from Gabon.

Authors: Held J, Westerman R, Kremsner PG, Mordm&#xFC;ller B We assessed the in vitro activity of mirincamycin, a lincosamide antibiotic, against Plasmodium falciparum clinical isolates from Gabon. Growth was determined by HRP2-ELISA using an adapted protocol with prolonged incubation time (6 days) to account for antibiotic induced delayed death. Mirincamycin's cis and trans isomers are more active (median IC50: 3.2 nM and 2.6 nM) than the comparator drugs clindamycin (IC50: 12 nM) and doxycycline (IC50: 720 nM) and therefore further clinical development is promising. PMID: 19841147 [PubMed - as supplied by publisher] (Source: Antimicrobial Agents and Chemotherapy)<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>

EVOCLIN (Clindamycin Phosphate) Aerosol, Foam [Stiefel Laboratories Inc]

Updated Date: Oct 14, 2009 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

ACANYA (Clindamycin Phosphate And Benzoyl Peroxide) Kit [Dow Pharmaceuticals Sciences]

Updated Date: Oct 14, 2009 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

Flucloxacillin, still the empirical choice for putative Staphylococcus aureus infections in intensive care units in the Netherlands

Conclusions The empirical choice of flucloxacillin in the case of putative S. aureus infections in patients admitted to ICUs in the Netherlands is still justified. (Source: Journal of Antimicrobial Chemotherapy)

CLINDAMAX (Clindamycin Phosphate) Gel [ PharmaDerm, A Division Of Nycomed US Inc.]

Updated Date: Oct 9, 2009 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

ZIANA (Clindamycin Phosphate And Tretinoin) Gel [Medicis Pharmaceutical Corp]

Updated Date: Oct 9, 2009 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>

Effects of Subinhibitory Concentrations of Antibiotics on Colonization Factor Expression by Moxifloxacin-Susceptible and Moxifloxacin-Resistant Clostridium difficile Strains.

The objective of this study was to analyze expression of these genes in the same conditions in four NAP1/027 strains, one moxifloxacin-susceptible and three moxifloxacin-resistant strains. Two in vitro selected moxifloxacin-resistant mutants were also analyzed. Moxifloxacin resistance was associated to the Thr82--&gt;Ile substitution in GyrA in all moxifloxacin-resistant strains but one. The expression of cwp84 and slpA was strongly increased after culture with ampicillin or clindamycin in NAP1/027 strains. Interestingly, after culture with fluoroquinolones, the expression of cwp84 and slpA was only increased in four moxifloxacin-resistant strains, including the NAP1/027 strains and one of the in vitro selected mutants. The cwp84 overexpression was correlated with an increased production o...

Clindamycin-induced CovS-mediated regulation of the production of the virulent exoproteins streptolysin O, NAD glycohydrolase, and streptokinase in Streptococcus pyogenes.

Authors: Minami M, Kamimura T, Isaka M, Tatsuno I, Ohta M, Hasegawa T The administration of high-dose clindamycin (CLI) along with penicillin is recommended for the treatment of streptococcal toxic shock syndrome. However, the prevalence of CLI-resistant Streptococcus pyogenes is increasing worldwide, and the effect of CLI on CLI-resistant S. pyogenes remains unknown. We aimed to evaluate the effect of CLI on the in vitro production of 3 major virulent exoproteins, namely, streptolysin O (Slo), NAD-glycohydrolase (Nga), and streptokinase (Ska), by CLI-resistant S. pyogenes. After incubation of M1 serotype CLI-resistant S. pyogenes D2TY in the presence of 1 mug/mL CLI, the amounts of Slo, Nga, and Ska and the mRNA levels of slo, nga, and ska in the supernatant were analyzed by northern ...

[Stevens-Johnson syndrome plus intrahepatic cholestasis caused by clindamycin or chlorpheniramine]

We present a discussion of this case and review the main characteristics of the Stevens Johnson Syndrome. PMID: 19624990 [PubMed - indexed for MEDLINE] (Source: Dermatol Online J)

Antibiograms and Molecular Subtypes of Methicillin-Resistant Staphylococcus aureus in Local Teaching Hospital, Malaysia.

In conclusion, no vancomycin-resistant isolate was observed. The Malaysian MDR MRSA isolates were mostly SCCmec type III and negative for PVL. These strains were genetically distinct from the SCCmec type IV strains, which were sensitive to SXT, tetracycline, and erythromycin. Only two strains were SCCmec IV and PVL-positive. The infections in the hospital concerned were probably caused by multiple subtypes of MRSA. PMID: 19884790 [PubMed - in process] (Source: Journal of Microbiology and Biotechnology)

Topical clindamycin in post-adenotonsillectomy analgesia in children: A double-blind, randomized clinical trial

Conclusion: The use of topical clindamycin was beneficial in reducing pain on the first postoperative day, without effect on subsequent days. Future investigations could examine the use of topical clindamycin not only in the first 12 hours but also during five days of follow-up. (Source: Otolaryngology - Head and Neck Surgery)<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>

Idiopathic pustular vulvitis

A 31-year-old woman presented in the 23rd week of her third pregnancy with extremely painful pustular vulvitis, unresponsive to antibiotics. Although the histological findings were was consistent with a diagnosis of hidradenitis suppurativa (HS), bridged comedones, the hallmark of this disease, were absent and there were no dermal sinuses. Incision and drainage of the pustules provided only temporary improvement, which was briefly maintained with oral clindamycin and topical steroids. After the birth, a course of isotretinoin produced almost total clearance, a response not typically found in HS. This patient's condition may represent a variant of HS, and if so, it would be the first case report of de novo HS in pregnancy, but its clinical features and evolution differed so much from those ...

Perrigo Acquires ANDA for Generic Version Duac(R) Gel From KV Pharmaceutical

ALLEGAN, Mich., Sept. 21 (HSMN NewsFeed) -- Perrigo Company (Nasdaq: PRGO;TASE) today announced that it has purchased the ANDA for clindamycin phosphate (1%) and benzoyl peroxide (5%) gel from KV Pharmaceutical for $14 million in cash at closing and a $2... Biopharmaceuticals, Generics, Dermatology, AcquisitionsPerrigo, KV Pharmaceutical, clindamycin, benzoyl peroxide (Source: HSMN NewsFeed)

Perrigo Acquires ANDA For Generic Version Duac&reg; Gel From KV Pharmaceutical

Perrigo Company (Nasdaq: PRGO;TASE) today announced that it has purchased the ANDA for clindamycin phosphate (1%) and benzoyl peroxide (5%) gel from KV Pharmaceutical for $14 million in cash at closing and a $2 million milestone payment upon the completion of a successful technical transfer. (Source: Pharmaceutical Online News)

Efficacy of antibiotic therapy for SAPHO syndrome is lost after its discontinuation: interventional study

Conclusions: For the period of application, the antibiotic therapy seems to have controlled the disease. After antibiotics discontinuation however, disease relapse was observed. SAPHO syndrome thus groups with other chronic inflammatory arthropathies with a need of permanent therapy. (Source: Arthritis Research and Therapy)

OBSERVATION: Interaction of Topical Sulfacetamide and Topical Dapsone With Benzoyl Peroxide

Conclusions&nbsp; Knowledge of the chemical reaction between benzoyl peroxide and sulfacetamide and dapsone will help minimize the occurrence of this interaction on our patients' skin. (Source: Archives of Dermatology)<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>

Varied Prevalence of Clostridium difficile in an Integrated Swine Operation.

The objectives of this study were to compare the prevalence of Clostridium difficile (Cd) among different age and production groups of swine in a vertically integrated swine operation in Texas in 2006 and to compare our isolates to other animal and human isolates. Results are based on 131 Cd isolates from 1008 swine fecal samples and pork trim samples (overall prevalence of 13%). The prevalence (number positive/number tested in production type) of Cd was different between the groups (P&lt;/=0.001), and was highest among suckling piglets at 50.0% (61/122), followed by 23.8% (34/143) for lactating sows and effluent from the farrowing barn, 8.4% (10/119) for nursery, 6.5% (4/62) for pork products, 3.9% (15/382) for grower-finisher, and 3.9% (7/180) for breeding boars and sows. Of the 131 isol...

Cost analysis and antimicrobial susceptibility testing comparing the E test and the agar dilution method in Campylobacter jejuni and Campylobacter coli

Abstract: Although numerous reports have compared the antimicrobial susceptibility of Campylobacter spp., controversy still exists about the use of the E test as an alternative to the agar dilution method suggested by the Clinical and Laboratory Standards Institute. MICs of 8 antimicrobials were determined using the E test and agar dilution methods for 103 Campylobacter jejuni and Campylobacter coli isolates from fresh chicken randomly purchased from stores in 3 southern Ontario counties. Overall, 72.6% of E test MIC values were within 1 log2 dilution and 95.7% within 2 log2 dilutions of the corresponding agar dilution MICs. For individual antimicrobials, agreement within 1 log2 dilution and 2 log2 dilutions was as follows: ampicillin (n = 103), 90.3% and 98.1%, respectively; chloramphenic...

Isolation and characterization of methicillin-resistant Staphylococcus aureus from swine and workers in China

Conclusions MRSA from Chinese pigs and farm workers (ST9) differed from the European pig-associated clone (ST398) with regard to clonal type, SCCmec content and resistance profile. (Source: Journal of Antimicrobial Chemotherapy)

Inappropriate use of vancomycin for preventing perinatal group B streptococcal (GBS) disease in laboring patients

Journal of Perinatal Medicine 37 (5): 487-489 Abstract Objective: The 2002 CDC guidelines for the prevention of perinatal group B streptococcus (GBS) stipulate that vancomycin is reserved for penicillin-allergic women at high risk for beta-lactam anaphylaxis with resistance to clindamycin or erythromycin. Our objective was to evaluate practitioner adherence to these guidelines. Methods: This is a retrospective chart review of patients admitted to labor and delivery who received vancomycin for GBS prophylaxis from January 1st, 2005 to June 1st, 2007. Identification and documentation of allergic reactions to beta lactams and performance of GBS sensitivities at the time of screening were recorded. Results: Eighty-seven patients reporting a penicillin allergy received vancomycin during labor. ...

Healthy People Taking Antibiotics May Spread Superbug Infection

We present these findings in protest of the way in which they were acquired.Reference: Lawley T D et al. "Antibiotic treatment of Clostridium difficile carrier mice triggers a supershedder state, transmission, and severe disease in immunocompromised hosts." Infection and Immunity. Published ahead of print, doi:10.1128/IAI.00558-09. For more information: http://www.sanger.ac.uk/Info/Press/2009/090721.shtml http://www.cdc.gov/ncidod/dhqp/id_CdiffFAQ_general.html http://www.mayoclinic.com/health/c-difficile/DS00736 (Source: NaturalNews.com)<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>

In&nbsp;vitro susceptibility to 17 antimicrobials of clinical Clostridium difficile isolates collected in 1993&#x2013;2007 in Sweden

This study investigated the MICs of 17 antimicrobials, for 606 toxigenic clinical isolates of Clostridium difficile collected between 1993 and 2007 in Sweden. Low MIC90 values were found for metronidazole (0.5 mg/L), vancomycin (1.0 mg/L), teicoplanin (0.125 mg/L), fusidic acid (1.0 mg/L), linezolid (2.0 mg/L), daptomycin (2.0 mg/L) and tigecycline (0.064 mg/L). Three isolates (0.5%) had elevated MICs for vancomycin (4[ndash]8 mg/L); however, these isolates originated from the same patient, who was receiving long-term intravenous vancomycin treatment. High-level clindamycin resistant isolates (MIC >256 mg/L) peaked in 1997 with 39 of 95 (41%) and out of these, 36% were also highly resistant to erythromycin. [beta]-Lactams such as penicillin V and piperacillin displayed MIC90s of 8 and 32 m...

CLINDAMAX LOTION (Clindamycin Phosphate) Suspension [PharmaDerm, A Division Of Nycomed US Inc.]

Updated Date: Sep 2, 2009 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

New susceptibility breakpoints in antimicrobial resistance rates of invasive pneumococcal strains.

CONCLUSIONS: When the new breakpoints for in vitro susceptibility were applied, penicillin resistance rates dropped 97%, from 33 to 1%. PMID: 19830357 [PubMed - in process] (Source: Jornal de Pediatria)

Clindamycin: Drug hypersensitivity: case report

(Source: Reactions)

CLINDAMYCIN HYDROCHLORIDEcapsule [Aurobindo Pharma Limited]

Updated Date: Aug 31, 2009 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>

Toxoplasma gondii: a simple Real-time PCR assay to quantify the proliferation of the apicoplast.

Authors: Wu L, Chen SX, Jiang XG, Cao JP A Real-time quantitative PCR assay to quantify the Toxoplasma gondii apicoplast was studied. Primers were designed to amplify a 305 bp product specific to T. gondii apicoplast. Standard curves were generated for both T. gondii apicoplast DNA and genomic DNA, and were used to compute the relative concentration of apicoplast DNA copies in the test samples. The results indicated that the copies of T. gondii apicoplast DNA was significantly low when exposed to ciprofloxacin, clindamycin and azithromycin for 48 h in the second infectious cycle. Our study shows that the Real-time PCR technique is a simple and quick technique for screening the anti-apicoplast drugs. PMID: 19720060 [PubMed - as supplied by publisher] (Source: Experimental Parasitolo...

Mylan Begins Marketing First Generic Version of BenzaClin(R) Acne Treatment

PITTSBURGH, Aug. 27 (HSMN NewsFeed) -- Mylan Inc. (Nasdaq: MYL ) today announced that its subsidiary Mylan Pharmaceuticals Inc. has begun to market 1% Clindamycin and 5% Benzoyl Peroxide Gel based on an agreement with licensing partner Dow Pharmaceutical... Biopharmaceuticals, Generics, DermatologyMylan, Clindamycin, Benzoyl Peroxide, BenzaClin, sanofi-aventis, acne (Source: HSMN NewsFeed)

Update on Babesiosis

Human babesiosis is an emerging tick-borne infectious disease caused by intraerythrocytic protozoan species of the genus Babesia with many clinical features similar to those of malaria. Over the last 50 years, the epidemiology of human babesiosis has changed from a few isolated cases to the establishment of endemic areas in the northeastern and midwestern United States. Episodic cases are reported in Europe, Asia, Africa, and South America. The severity of infection ranges from asymptomatic infection to fulminant disease resulting in death, although the majority of healthy adults experience a mild-to-moderate illness. People over the age of 50 years and immunocompromised individuals are at the highest risk of severe disease, including those with malignancy, HIV, lacking a spleen, or receiv...

Bacteriological profile and antimicrobial resistance patterns of clinical bacterial isolates in a University Hospital

The objective of this study was to determine the patterns of bacterial isolates found in blood culture of patients with bactermia in King Abdul Aziz University Hospital in addition to determination of antibiotic resistance. A retrospective analysis of the 672 positive samples collected over the period of December 2006‚??December 2008. The observed mean age was 40 years with comparable distribution in both genders. 65.2% of the population were Non-Saudi. 65.5% of isolates were Gram positive, mainly Staphylococcus epidermidis, on the other hand Klebsiella was the common Gram negative bacteria. Diabetes has been observed in 38.5%. Mortality was 32.4 (P-value 0.001) in diabetic patients versus non-diabetics. Benzyl penicillin, clindamycin, erythromycin, tetracycline, ciprofloxacin, oxacillin c...

Clindamycin/risedronic acid: Oesophagitis: case report

(Source: Reactions)<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>

Photocarcinogenesis and toxicity of benzoyl peroxide in hairless mice after simulated solar radiation

Abstract: Topical benzoyl peroxide (BPO) gel has long been used to treat acne vulgaris and has recently been combined with clindamycin (BPO-clin). No skin malignancies have been reported after clinical use of BPO, but there has been concern about the possible carcinogenicity of BPO alone and in combination with UV radiation. BPO can promote skin tumorigenesis in a mouse skin chemical carcinogenesis model. As acne vulgaris is frequently localized on sun-exposed areas, we investigated whether BPO or BPO-clin accelerates photocarcinogenesis in combination with simulated solar radiation (SSR) in 12 groups of 25 hairless female C3.Cg/TifBomTac-immunocompetent mice. BPO or BPO-clin was applied topically to the back five times each week, followed by SSR three times each week (2, 3, or 4 standard ...

Excretion of Antimicrobials Used to Treat Methicillin-Resistant Staphylococcus aureus Infections During Lactation: Safety in Breastfeeding Infants

Pharmacotherapy 29(9): 1103-1109 Abstract Community-acquired strains of methicillin-resistant Staphylococcus aureus (MRSA) have become a common cause of skin and soft tissue infections in the United States. These infections sometimes require treatment with antibiotics, and with the increasing resistance of pathogens to these agents, choosing the appropriate drug can be difficult. In lactating women who develop these infections, selecting an antibiotic is even more challenging, as clinicians need to be aware of risks to the infant from the drug excreted during lactation. To our knowledge, no review has addressed the safety of antibiotics in breastfeeding infants when the drugs are used to treat maternal skin and soft tissue infections from MRSA. Thus, we performed a literature search of the...

Simultaneous Determination of Several Antibiotics: Application to Human Plasma Extracts, and Impurities and Degradants in Drug Preparations

This application note describes a gradient HPLC-EC Array method for the determination of beta-lactam and macrolide antibiotics. The method has low pg sensitivity, a wide dynamic range, excellent linearity and demonstrates the determination of vancomycin, azithromycin, clindamycin, erythromycin, oleandomycin and amoxicillin in extracts of human plasma. Impurities and degradants in pharmaceuticals were determined at the 0.1% level. (Source: PharmaManufacturing.com)

BSAC standardized disc susceptibility testing method (version 8)

There have been considerable changes to the format of the recommendations since the previous version (version 7). The majority of the footnotes to the tables have been removed and the notations added to the end column; it is hoped that this change will avoid confusion in interpretation. Antibiotics have been separated into groups, e.g. &beta;-lactams, aminoglycosides, etc. Recommendations for urinary tract infections (UTIs) have been removed for most agents except for those that are administered solely for the treatment of uncomplicated UTIs or where there are limited recommendations for specific organisms, e.g. trimethoprim. For agents that previously had dual recommendations, systemic recommendations remain and the intermediate category can be used for interpretation for UTIs because int...

Clindamycin: Hypercholesterolaemia (first report) treated with probiotic: case report

(Source: Reactions)<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>

Effect of clindamycin treatment on vaginal inflammatory markers in pregnant women with bacterial vaginosis and a positive fetal fibronectin test

Abstract: Objective: To compare the levels of interleukin (IL)-1ő≤, IL-6, and matrix metalloproteinase (MMP)-8 in the vaginal secretions of pregnant women with a positive fetal fibronectin (fFN) test result with or without asymptomatic bacterial vaginosis (BV) before and after treatment with oral clindamycin.Methods: A prospective cohort study was conducted among 43 pregnant women with a positive fFN test result. All patients were treated with clindamycin, and the pre- and post-treatment levels of IL-1ő≤, IL-6, and MMP-8 were compared.Results: Before treatment, levels of IL-1ő≤ and MMP-8 were significantly higher in women with BV compared with women without BV (P (Source: International Journal of Gynaecology and Obstetrics)

Tubo-ovarian abscess with Morganella morganii bacteremia.

This report highlights the fact that antimicrobial resistance of M. morganii may complicate the management and outcome of this infection. PMID: 19949761 [PubMed - in process] (Source: Journal of Microbiology, Immunology, and Infection)

Resistance Trends of Bacteroides fragilis Group Over an 8-Year Period, 1997-2004, in Korea.

CONCLUSIONS: Piperacillin-tazobactam, cefoxitin, imipenem, chloramphenicol, and metronidazole are still active against B. fragilis group isolates, while clindamycin no longer has a value as an empirical therapeutic agent in Korea. Furthermore, this study identified the first imipenem-resistant B. fragilis group isolates in Korea. PMID: 19726890 [PubMed - in process] (Source: The Korean Journal of Laboratory Medicine)

Clindamycin vasculitis in patients with peripheral arterial vascular disease

We report two cases of necrotizing vasculitis due to clindamycin which was used for the treatment of chronic wounds in patients suffering of peripheral vascular disease. Content Type Journal ArticleCategory Case ReportDOI 10.1007/s00238-009-0343-6Authors Jamil Al-Jamali, University of Freiburg Medical Center Department of Plastic and Hand Surgery Freiburg GermanyGunther Felmerer, University of Freiburg Medical Center Department of Plastic and Hand Surgery Freiburg GermanyAhmed Kasem, University of Freiburg Medical Center Department of Plastic and Hand Surgery Freiburg GermanyKhalid Al-awadi, University of Freiburg Medical Center Department of Plastic and Hand Surgery Freiburg GermanyZiad Kalash, University of Freiburg Medical Center Department of Plastic and Hand Surgery Freiburg Ger...

Chlorphenamine/clindamycin: Intrahepatic cholestasis (first report with chlorphenamine) and first report of Stevens-Johnson syndrome: case report

(Source: Reactions)<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>

[In Process Citation]

We present a discussion of this case and review the main characteristics of the Stevens Johnson Syndrome. PMID: 19624990 [PubMed - in process] (Source: Dermatol Online J)

Antibiotic Use by Members of the Spanish Endodontic Society

Conclusions: For the most part, the majority of the members of the AEDE were selecting the appropriate antibiotic for use in orofacial infections, but there are still many who are prescribing antibiotics inappropriately. The use of antibiotics for minor infections, or in some cases in patients without infections, could be a major contributor to the world problem of antimicrobial resistance. (Source: Journal of Endodontics)

I PREVENT Bacterial Resistance. An Update on the Use of Antibiotics in Dermatologic Surgery

Prophylaxis may be given to prevent a surgical wound infection, infective endocarditis (IE), or infection of a prosthetic joint, but its use before cutaneous surgery is controversial. Our aim was to review the current literature and provide a mnemonic to assist providers in appropriately prescribing prophylactic antibiotics. We reviewed the current literature, including the new guidelines provided by the American Heart Association (AHA). The new AHA guidelines recommend prophylaxis for patients with high risk of an adverse outcome from IE instead of high risk of developing IE. The American Academy of Orthopedic Surgeons and the American Dental Association also provide guidelines. Given the paucity of conclusive studies, prophylaxis against a surgical wound infection is based more on clinic...

Investigation of enantiomeric separation of basic drugs by capillary electrophoresis using clindamycin phosphate as a novel chiral selector

In this study clindamycin phosphate belonging to the group of lincomycin antibiotics is first used as a novel chiral selector for the enantiomeric separations of several racemic basic drugs, which possess high separability, consisting of nefopam, citalopram, tryptophan, chlorphenamine and propranolol. Other basic drugs giving partial enantioseparation include tryptophan methyl ester, metoprolol and atenolol. Clindamycin phosphate possesses advantages such as high solubility and low viscosity in the water and very weak UV absorption. In the course of this work we observed that both migration time and enantioseparation were influenced by several parameters such as pH of the BGE, clindamycin concentration, capillary temperature, applied voltage and organic modifier. The optimum pH that was in...

[Malaria in the South of Madrid: A clinical and epidemiological review.]

CONCLUSIONS: The incidence of pediatric malaria is increasing in the southern area of Madrid, with P. falciparum as the most frequently identified species. Microscopic visualization or identification of its antigen are gold-standard diagnostic methods, however, identification with PCR is essential upon admission to determine the species and discard possible multiple infestations. Pediatricians must learn to suspect this potentially severe disease, in order to establish an early treatment that may improve the prognosis. PMID: 19620029 [PubMed - as supplied by publisher] (Source: Anales de Pediatria)<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>

Bacterial Vaginosis Treatments Vary in Efficacy, Adverse Effects

Clindamycin preparations, oral metronidazole, and oral and intravaginal lactobacillus were effective for bacterial vaginosis, but hydrogen peroxide douche and triple sulfonamide cream were not. Medscape Medical News (Source: Medscape Pharmacist Headlines)

Epidemiology of community-onset Staphylococcus aureus infections in pediatric patients: an experience at a Children's Hospital in central Illinois

Conclusions: Epidemiological data at the local level is important for antimicrobial decision-making. MSSA remains an important pathogen causing invasive community-onset S. aureus infections among hospitalized children. In our hospital, nafcillin in combination with vancomycin is recommended empiric therapy in critically ill patients with suspected invasive staphylococcal infections. Because up to 25% of MSSA circulating in our area are clindamycin-resistant, clindamycin should be used cautiously as empiric monotherapy in patients with suspected invasive staphylococcal infections. (Source: BMC Infectious Diseases)

Distinct ribotypes and rates of antimicrobial drug resistance in Clostridium difficile from Shanghai and Stockholm

Clin Microbiol Infect Seventy-five clinical isolates of Clostridium difficile from Shanghai and 80 from Stockholm were investigated. The prevalence of toxin A-negative, toxin B-positive isolates of C. difficile among isolates from Shanghai (33.3%) was significantly higher than among isolates from Stockholm (0%). Both sets of isolates were fully susceptible to metronidazole and vancomycin. However, the MICs of fluoroquinolones, erythromycin[ndash]clindamycin, tetracycline, rifampin and fusidic acid were significantly higher for the Shanghai isolates than for the Stockholm isolates. Thirty-three PCR ribotypes were identified; a dominant clone, 017, accounted for 18.7% of Shanghai isolates, whereas clone 005 dominated among Stockholm isolates, accounting for 11.3%. Strains 027 and 078 were no...

Cancrum Oris: A case report

Abstract&nbsp;&nbsp;Cancrum Oris is acute gangrenous stomatitis of oral and para-oral structures in age group between 2 to 16 years particularly in sub-Saharan Africa with high morbidity and mortality. Exact bacteriology is uncertain. Acute necrotising gingivitis and oral herpetic ulcers are considered to be antecedent lesions. The treatment of cancrum oris is penicillin, tetracycline, metronidazol and clindamycin. second step of management includes reconstructive surgery for the treatment of the functional and cosmetic problems. The authors are reporting a case of cancrum oris in a 1.5-year-old child. Content Type Journal ArticleCategory Short CommunicationDOI 10.1007/BF03049618Authors Sudhakar Vaidya, R D Gardi Medical College & Ujjain Charitable Hospital Dept. of Otorhinolaryng...

Antibiotic clindamycin can cause a dangerous gastrointestinal infection

Your column contained a question regarding diarrhea from the antibiotic clindamycin. You advised the writer to see a gastroenterologist. (Source: L.A. Times - Health)<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>

Contribution of Genetically Restricted, Methicillin‚?źSusceptible Strains to the Ongoing Epidemic of Community‚?źAcquired Staphylococcus aureus Infections

Conclusions.‚??In addition to methicillin‚?źresistant strains, the current epidemic of S. aureus infections includes infections caused by methicillin‚?źsusceptible strains that are closely related genetically and share phenotypic characteristics other than susceptibility to methicillin. These findings suggest that factors other than methicillin resistance are driving the epidemic. (Source: Clinical Infectious Diseases Latest Issue)

Treatment of invasive streptococcal infection with a peptide derived from human high-molecular weight kininogen

Sepsis and septic shock remain an important medical problem, emphasizing the need to identify novel therapeutic opportunities. Hypovolemic hypotension, coagulation dysfunction, disturbed microcirculation, and multiorgan failure resulting from vascular leakage are often observed in these severe conditions. In the present study, we find that HKH20, a peptide derived from human high molecular weight kininogen (HK), down-regulates inflammatory reactions caused by Streptococcus pyogenes in a mouse model of sepsis. HK is a component of the pro-inflammatory and pro-coagulant contact system. Activation of the contact system in the bloodstream by S pyogenes leads to massive tissue damage in the lungs of the infected mice, which eventually results in the death of the animals. HKH20 inhibits activati...

The Effect of Combined Treatment with Oral Clindamycin and Oral Rifampicin in Patients with Hidradenitis Suppurativa

Dermatology (DOI:10.1159/000228337) (Source: Dermatology)

Combination Therapy with Clindamycin and Rifampicin for Hidradenitis Suppurativa: A Series of 116 Consecutive Patients

Dermatology (DOI:10.1159/000228334) (Source: Dermatology)

BenzaClin (Clindamycin and Benzoyl Peroxide) - updated on RxList

BenzaClin (Clindamycin and Benzoyl Peroxide) drug description - FDA approved labeling for prescription drugs and medications at RxList (Source: RxList - New and Updated Drug Monographs)<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>

What Are the Presenting Problems of Staphylococcus in Neonates?

Discussion Staphylococcus sp. are gram-positive, catalase-positive cocci that cluster when viewed microscopically. There are 17 species indigenous to humans and 13 colonize humans. Staphylococcus aureus is the only species that produces coagulase. Staphylococcus sp. can be found in almost any environment including high salt, low oxygen, high heat and low moisture. Coagulase-negative Staphylococcus sp. are so common that newborn infants are colonized by 2-4 days of life usually with S. epidermidis and S. haemolyticus. Staphylococcus aureus produces many infections especially pneumonia and surgical wound infections. Humans can be colonized with it especially in mucous membranes and the perineum and axilla. Those with nasal carriage can also transiently carry the organism on their hands, thu...

[Comparison between two antibiotic schemes in relation to surgical site infection in children: a randomized clinical trial.]

Conclusions: AP administered 2 h before incision and continuing for 24 h significantly decreases the risk of SSI compared to CG in clean-contaminated procedures. PMID: 19919789 [PubMed - as supplied by publisher] (Source: Cirugia y Cirujanos)

Physicochemical characterization and skin permeation of liposome formulations containing clindamycin phosphate.

This study was undertaken to evaluate the physicochemical properties and skin permeation of liposome formulations containing clindamycin phosphate (CP), especially when charge was imparted to the liposome. Five different liposome formulations were prepared using Phospholipon 85G (PL) and cholesterol (CH) by conventional lipid film hydration technique. Molar ratio of CH to PL was varied in the range of 0.16-1.0. Charged liposomes were prepared in the same way with addition of 1,2-dioleoyl-3-trimethylammonium-propane chloride salt (DOTAP) and 1,2-dimyristoyl-sn-glycero-3-phosphate monosodium salt (DMPA) as charge carrier lipid for cationic or anionic charge of the liposome, respectively. Fresh full-thickness mice skin was taken and used for skin permeation study using Keshary-Chien diffusion...

Antimicrobial susceptibility of Staphylococcus aureus isolated from children with impetigo in China from 2003 to 2007 shows community-associated methicillin-resistant Staphylococcus aureus to be uncommon and heterogeneous

Conclusions CA-MRSA is still relatively uncommon and heterogeneous in children in China. Penicillin and erythromycin are no longer appropriate agents. Effective antibiotic agents for patients with impetigo are mupirocin and fusidic acid. (Source: British Journal of Dermatology)

Methicillin-resistant Staphylococcus aureus (MRSA): identification and susceptibility testing techniques.

Authors: Reygaert W Many traditional techniques are useful for identification of MRSA strains, including techniques for detection of penicillin-resistance, such as the nitrocefin disk. Techniques for assessing methicillin-resistance vary from growth on special media or at a lower temperature, to detection of the mecA gene by manual (latex agglutination) and automated (PCR) methods. Technique development is now geared toward making MRSA identification more rapid. Real-time PCR has sped MRSA detection, but can be costly. Resistance to other drugs is also an issue. Clindamycin resistance may need to be induced, so a special disk diffusion test can be performed. Vancomycin resistance is becoming an issue, so alternative drugs need to be identified. Drugs that are currently available for MR...<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>

Vaginal carriage and antibiotic susceptibility profile of group B Streptococcus during late pregnancy in Ismailia, Egypt

Summary: Group B Streptococcus (GBS) infection has long been recognized as a frequent cause of morbidity and mortality in newborn infants. The purpose of this study was to determine the colonization rate with GBS and the antibiotic susceptibility profile in pregnant women attending Gynecological clinics in Egypt. One-hundred and fifty vaginal swabs were collected from pregnant women at 35‚??40 weeks of gestation. In comparison to culture, direct latex agglutination testing revealed 100% sensitivity and 93.75% specificity. Thirty-eight specimens (25.3%) were found to be positive for GBS. Each isolate was tested for susceptibility to penicillin G, ampicillin, cefotaxime, erythromycin, clindamycin and vancomycin. Erythromycin-resistant isolates were further classified by double-disk method. A...

CLINDAMYCIN PHOSPHATEsolution CLINDAMYCIN PHOSPHATEgel CLINDAMYCIN PHOSPHATElotion [E. FOUGERA And CO.]

Updated Date: Jun 23, 2009 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

CLINDAMYCIN PHOSPHATEcream [E. FOUGERA CO.]

Updated Date: Jun 23, 2009 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

Long-term symptomatic group B streptococcal vulvovaginitis: Eight cases resolved with freshly cut garlic

We found that neither an accepted diagnostic definition nor a treatment has been established for group B streptococcal (GBS) vulvovaginitis. A review of the literature revealed five previous articles describing a combined total of 26 cases of GBS vaginitis in the absence of other pathogens . GBS vulvovaginitis presents with complaints of vulvar burning and clear or white vaginal discharge. The labia appear fiery-red, sometimes with fissures. It has been reported in both celibate and non-celibate women. Cultures contain GBS at a high multiplicity: >100,000,000 colony-forming units (CFU)/g of vaginal fluid or ++++ growth and decreased lactobacillus. GBS vaginitis is sometimes identified as aerobic vulvovaginitis. High colonization with GBS appears to provoke the release of cytokines causing ...

The prevalence of antimicrobial resistance and carriage of virulence genes in Staphylococcus aureus isolated from food handlers in Kuwait City restaurants

Conclusions: This study revealed a high prevalence of antibacterial resistance and virulence determinants in S. aureus from food handlers in Kuwait restaurants justifying the screening of food handlers to detect and treat carriers and protect restaurant customers from staphylococcal food poisoning. (Source: BMC Research Notes)<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>

Toxin A-producing Clostridium difficile as an aetiological factor of post-traumatic wound infection.

Authors: Deptula A, Kruszynska E, Mikucka A, Gospodarek E, Olszewski K, Kruczynski J, Matewski D Clostridium difficile is a well-known cause of hospital-acquired infection such as antibiotic associated diarrhoea or pseudomembranous colitis. Extraintestinal infections caused by this pathogen are described rarely. A case of post-traumatic wound infection caused by C. difficile in an immunocompetent, young and otherwise healthy trauma patient is reported. A 31-year-old female, a car accident victim, was admitted to hospital because of polytrauma. After open reduction and internal fixation of a supracondylar femoral fracture by means of the dynamic condylar screw (DCS) system, a purulent fistula occurred. Microbiological examination of the pus revealed C. difficile as the single aetiologic...

Clindamycin can trigger dangerous diarrhea

The antibiotic can allow a bad bacteria to flourish in the intestines and the condition could be lethal if left untreated. For an abscessed tooth, I was given an antibiotic called clindamycin. Ever since I took it, I have had unremitting diarrhea. My dentist wants me to see a gastroenterologist. (Source: L.A. Times - Health)

Antibiotic Resistance Patterns in Invasive Group B Streptococcal Isolates

Antibiotics are used for both group B streptococcal (GBS) prevention and treatment. Active population-based surveillance for invasive GBS disease was conducted in four states during 1996&#8211;2003. Of 3813 case-isolates, 91.0&#37; (3471) were serotyped, 77.1&#37; (2937) had susceptibility testing, and 46.6&#37; (3471) had both. All were sensitive to penicillin, ampicillin, cefazolin, cefotaxime, and vancomycin. Clindamycin and erythromycin resistance was 12.7&#37; and 25.6&#37;, respectively, and associated with serotype V (P&#x0003C;.001). Clindamycin resistance increased from 10.5&#37; to 15.0&#37; (X2 for trend 12.70; P&#x0003C;.001); inducible clindamycin resistance was associated with the erm genotype. Erythromycin resistance increased from 15.8&#37; to 32.8&#37; (X2 for trend 55.46;...

Necrotizing Pneumonia Caused by Panton-Valentine Leucocidin-Producing Staphylococcus aureus Originating from a Bartholin&#39;s Abscess

Conclusions. S. aureus, in particular PVL-positive strains, should be considered when a young, immunocompetent person develops a fulminant necrotizing pneumonia. Minor infections&#8212;such as Bartholin&#39;s abscess&#8212;can precede this life-threating syndrome. Bactericidal antistaphylococcal antibiotics are recommended for treatment, and surgical procedures may become necessary. (Source: Infectious Diseases in Obstetrics and Gynecology)<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>

Vaginal Microbiota and the Use of Probiotics

The human vagina is inhabited by a range of microbes from a pool of over 50 species. Lactobacilli are the most common, particularly in healthy women. The microbiota can change composition rapidly, for reasons that are not fully clear. This can lead to infection or to a state in which organisms with pathogenic potential coexist with other commensals. The most common urogenital infection in premenopausal women is bacterial vaginosis (BV), a condition characterized by a depletion of lactobacilli population and the presence of Gram-negative anaerobes, or in some cases Gram-positive cocci, and aerobic pathogens. Treatment of BV traditionally involves the antibiotics metronidazole or clindamycin, however, the recurrence rate remains high, and this treatment is not designed to restore the lactoba...

Bacteriology and Management of Necrotizing Soft Tissue Infections

Roldan reports a case of necrotizing fasciitis in an elderly man in which the cultures grew group A hemolytic Steptococci, Clostridium perfringens, and Proteus, whereas Frazee et al. reviewed 122 cases of necrotizing soft tissue infections (). We wish to comment on two aspects of these reports. First, both articles comment on Clostridium-associated necrotizing soft tissue infections (NSTI), but incorrectly implicate C. botulinum and C. tetani as primary pathogens. Second, we question the omission of anti-toxin therapy, in the form of clindamycin and intravenous immunoglobulin (IVIG), in the management of Roldan's case. (Source: The Journal of Emergency Medicine)

BPO gel versus wash: One product combination has quicker onset

A study comparing the safety and efficacy of two acne combination therapies containing clindamycin, benzoyl peroxide and tretinoin showed that the regimen delivered in gel vehicles worked faster than the regimen that included a benzoyl peroxide wash, the study's author says. (Source: Modern Medicine)

Pyomyositis due to Streptococcus pneumoniae

We report a 12-year-old male with pyomyositis caused by Streptococcus pneumoniae who presented with fever and severe right hip and abdominal pain. Magnetic resonance imaging of the right hip revealed the diagnosis of pyomyositis. Blood cultures grew Streptococcus pneumoniae, sensitive to penicillin, ceftriaxone, and clindamycin. He was successfully treated with a 3-week course of clindamycin. Early recognition, appropriate antibiotic therapy, and if indicated, drainage of the muscle abscess is critical to reduce morbidity and mortality. (Source: The American Journal of Emergency Medicine)

Mediastinitis in infants from deep neck space infections

Conclusions: In infants with pediatric deep neck space infections, increased vigilance should be maintained for progression to mediastinal extension. Optimal management includes imaging of the neck and chest as indicated, broad-spectrum antibiotic coverage, and aggressive surgery as warranted to clear the neck space infections with appropriate surgical consultants to manage the mediastinal process. Despite high morbidity and mortality in adult mediastinitis, infant mediastinitis may be a different disease process as all patients survived without sequelae. (Source: Otolaryngology - Head and Neck Surgery)<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>

Methicillin-resistant Staphylococcus aureus (MRSA) osteomyelitis of the mandible

Methicillin-resistant Staphylococcus aureus (MRSA) is a type of Staphylococcus that is resistant to certain antibiotics, such as methicillin, oxacillin, penicillin, and amoxicillin. This nosocomial pathogen has become a great threat in hospitals globally. Up to 40% of the normal population carries S. aureus in the anterior nares, and this rate is often higher in hospitalized patients and their attendants. This case report presents a patient with serious MRSA osteomyelitis of the mandible demonstrating purulent discharge. The patient failed to recover despite prolonged postoperative treatment and the administration of several antibiotics. There was a resulting nonunion along with chronic MRSA infection. The treatment protocol involved a multimodal approach with parenteral clindamycin infusi...

A prospective study of methicillin-resistant Staphylococcus aureus colonization in children scheduled for elective surgery

Conclusion: Methicillin-resistant S aureus colonization was common in asymptomatic children. Most strains appeared to be health care‚??associated and resistant to clindamycin. Wound infection rate remained low despite the high prevalence of staphylococcal colonization. (Source: Journal of Pediatric Surgery)

Bacterial vaginosis - More questions than answers.

This article discusses the prevalence, clinical features and possible complications of bacterial vaginosis. It summarises what is known about the aetiology, pathophysiology and treatment of the condition and highlights directions for further research. DISCUSSION: Bacterial vaginosis is characterised by a complex disturbance of the normal vaginal flora with an overgrowth of anaerobic and other micro-organisms and a corresponding decrease in important lactobacillus species. The cause is not known, but observational evidence suggests the possibility of sexual transmission. Bacterial vaginosis is diagnosed by the Amsel or the Nugent method. Recommended treatment is with 7 days of oral metronidazole or vaginal clindamycin. More than 50% of women will experience recurrence of bacterial vaginosis...

[Evaluation of the BD Phoenix Automated Microbiology System SMIC/ID-2 Panel for Antimicrobial Susceptibility Testing of Streptococcus pneumoniae.]

CONCLUSIONS: The Phoenix SMIC/ID-2 panel provided a simple and rapid susceptibility testing for S. pneumoniae, and the results were in a good agreement with those of Etest. The Phoenix system appears to be an effective automated system in clinical microbiology laboratories. PMID: 19571618 [PubMed - in process] (Source: The Korean Journal of Laboratory Medicine)

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