GABAPENTIN Capsule [Direct Rx]

Updated Date: Feb 21, 2014 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

GABAPENTIN Tablet, Film Coated [Cardinal Health]

Updated Date: Feb 18, 2014 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

GABAPENTIN Capsule [Cardinal Health]

Updated Date: Feb 18, 2014 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

Analgesia for the Cirrhotic Patient: A Literature Review and Recommendations

Abstract The choice of analgesic agent in cirrhotic patients is problematic and must be individualized taking into account several factors including severity of liver disease, history of opioid dependence and potential drug interactions. With a cautious approach including slow dose up‚?źtitration and careful monitoring, effective analgesia can be achieved in most cirrhotic patients without significant side‚?źeffects or decompensation of their liver disease. Paracetamol is safe in patients with chronic liver disease but reduced doses of 2‚?ź3 grams daily is recommended for long term use. Non‚?źsteroidal anti‚?źinflammatory drugs (NSAIDs) are best avoided due to risk of renal impairment, hepato‚?źrenal syndrome and gastrointestinal haemorrhage. Opioids have an increased risk of toxicity part...

Gabapentin increased complete abstinence in alcohol-dependent patients seeking treatment.

Authors: Saitz R PMID: 24534932 [PubMed - in process] (Source: Annals of Internal Medicine)<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>

Effects of gabapentin enacarbil on restless legs syndrome and leg pain in dementia with Lewy bodies

Abstract Restless legs syndrome (RLS) is a common neurological disorder. Dementia with Lewy bodies (DLB) is the second most common form of neurodegenerative dementia after Alzheimer's disease. Both RLS and DLB can be effectively treated by dopaminergic medications, suggesting the role of dopamine dysfunction in the pathogenesis of both diseases. Here, I report on a Japanese woman with probable DLB and RLS who was treated with gabapentin enacarbil, a non‚?źdopaminergic agent. Because a dopamine agonist, a first‚?źline therapy for moderate to severe RLS, caused the occurrence of metamorphopsia, an alternative treatment of gabapentin enacarbil was used; this treatment improved the patient's RLS without worsening her psychiatric symptoms. An alternative treatment is desirable for DLB patients ...

GABAPENTIN (Gabapentin) Capsule [Pharmaceutica North America, Inc.]

Updated Date: Feb 14, 2014 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

Anticonvulsants for alcohol dependence.

CONCLUSIONS: At the current stage of research, randomised evidence supporting the clinical use of anticonvulsants to treat alcohol dependence is insufficient. Results are conditioned by heterogeneity and by the low number and quality of studies comparing anticonvulsants with other medications. The uncertainty associated with these results leaves to clinicians the need to balance possible benefits/risks of treatment with anticonvulsants versus other medications as supported by evidence of efficacy. PMID: 24523233 [PubMed - as supplied by publisher] (Source: Cochrane Database of Systematic Reviews)

Table of Contents

Abstract Long QT syndrome more likely in patients with HIV, hepatitis C Long‚?źterm treatments for obesity yield results with lifestyle changes Interaction of valproic acid with two drugs Topiramate study signals possible treatment for cocaine dependence Adjunctive modafinil improves depression, lessens fatigue D‚?źcycloserine, exposure therapy promising for treating PTSD Gabapentin results bode well for alcohol treatment by MDs Vortioxetine shows efficacy in treating major depression Better trials needed for SSRIs in stroke recovery Drug Safety Communication (Source: The Brown University Psychopharmacology Update)

gabapentin enacarbil, Horizant

Title: gabapentin enacarbil, HorizantCategory: MedicationsCreated: 2/11/2014 6:04:00 PMLast Editorial Review: 2/11/2014 6:04:18 PM (Source: MedicineNet Medications General)<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>

Clinical Outcomes in Newer Anticonvulsant Overdose: A Poison Center Observational Study.

Authors: Wills B, Reynolds P, Chu E, Murphy C, Cumpston K, Stromberg P, Rose R Abstract Clinicians have limited experience with assessment and treatment of overdose from newer anticonvulsant medications. The aim of this investigation was to evaluate clinical effects of newer anticonvulsant overdose, determine if a relationship exists between dose and clinical effect, and if a particular agent appears more toxic in overdose. This was a retrospective study using electronic poison center data, evaluating clinical outcomes from newer anticonvulsant overdose. The Toxicall‚?Ę database from January 1, 2002 to December 31, 2011 was queried using key words: "gabapentin," "lamotrigine," "levetiracetam," "tiagabine," "topiramate," "zonisamide," "pregabalin," and "oxcarbazine." Polypharmacy ov...

The neurology of itch

Research over the past 15 years has helped to clarify the anatomy and physiology of itch, the clinical features of neuropathic itch syndromes and the scientific underpinning of effective treatments. Two itch-sensitive pathways exist: a histamine-stimulated pathway that uses mechanically insensitive C-fibres, and a cowhage-stimulated pathway primarily involving polymodal C-fibres. Interactions with pain continue to be central to explaining various aspects of itch. Certain spinal interneurons (Bhlhb5) inhibit itch pathways within the dorsal horn; they may represent mediators between noxious and pruritic pathways, and allow scratch to inhibit itch. In the brain, functional imaging studies reveal diffuse activation maps for itch that overlap, but not identically, with pain maps. Neuropathic it...

GABAPENTIN Capsule [McKesson Packaging Services A Business Unit Of McKesson Corporation]

Updated Date: Feb 4, 2014 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

GABAPENTIN Tablet, Film Coated [McKesson Packaging Services A Business Unit Of McKesson Corporation]

Updated Date: Feb 4, 2014 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

Gabapentin increases extracellular glutamatergic level in the locus coeruleus via astroglial glutamate transporter-dependent mechanisms.

Authors: Suto T, Severino AL, Eisenach JC, Hayashida KI Abstract Gabapentin has shown to be effective in animals and humans with acute postoperative and chronic pain. Yet the mechanisms by which gabapentin reduces pain have not been fully addressed. The current study performed in vivo microdialysis in the locus coeruleus (LC) in normal and spinal nerve ligated (SNL) rats to examine the effect of gabapentin on extracellular glutamate concentration and its mechanisms of action with focus on presynaptic GABA-B receptors, astroglial glutamate transporter-1 (GLT-1), and interactions with őĪ2őī subunits of voltage-gated Ca(2+) channels and endogenous noradrenaline. Basal extracellular concentration and tissue content of glutamate in the LC were greater in SNL rats than normal ones. Intra...<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>

GABAPENTIN Capsule [PD-Rx Pharmaceuticals, Inc.]

Updated Date: Jan 31, 2014 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

GABAPENTIN Tablet [REMEDYREPACK INC. ]

Updated Date: Jan 31, 2014 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

GABAPENTIN Capsule [Cardinal Health]

Updated Date: Jan 28, 2014 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

Recurrent Facial Erythema with Burning Sensation and Increased Temperature: A Variant of Erythromelalgia or a New Entity?

ConclusionsThe present case is considered to be a variant of erythromelalgia. Its erythema may be resulted from the dilated vessels. Combination of modalities may provide effective management for erythromelalgia. ‚??Erythermalgia‚?Ě may be better than ‚??erythromelalgia‚?Ě to describe such conditions. (Source: Pain Medicine)

One-Year Swallowing Outcomes in Patients Receiving Gabapentin During Chemoradiation Therapy for Oropharyngeal Cancer: Survivorship

Recent observations by our study team have demonstrated that patients using gabapentin for pain management during chemoradiation therapy (CRT) are more likely to maintain an oral diet during treatment and require lower doses of narcotic analgesics. Additionally, these subjects were less likely to require or use PEG tubes during treatment, had less weight loss during treatment, and less short-term swallowing morbidity as measured by videofluoroscopic swallowing studies (VFSS). The purpose of this investigation was to characterize the long-term swallowing function of these patients one year following completion of treatment. (Source: International Journal of Radiation Oncology * Biology * Physics)<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>

GABAPENTIN Tablet, Film Coated [REMEDYREPACK INC. ]

Updated Date: Jan 10, 2014 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

Should anaesthetists routinely use a gabapentinoid perioperatively?

Authors: Sanders G Abstract Gabapentin and pregabalin have antiallodynic and antihyperalgesic properties, making them cornerstones in the treatment of neuropathic pain. There is now evidence that they also have an adjunctive role in the management of acute postoperative pain when administered perioperatively. PMID: 24401980 [PubMed - in process] (Source: British Journal of Hospital Medicine)

Pharmacoeconomic Outcomes for Pregabalin: A Systematic Review in Neuropathic Pain, Generalized Anxiety Disorder, and Epilepsy from a Spanish Perspective.

CONCLUSION: The majority of published evidence supports the possibility that pregabalin could be a cost-effective and/or cost-saving alternative for the treatment of refractory epilepsy, GAD, and neuropathic pain, in both treatment-na√Įve patients and in those who have demonstrated inadequate response or intolerance to previous therapy. PMID: 24390901 [PubMed - as supplied by publisher] (Source: Advances in Therapy)

GABAPENTIN Capsule [New Horizon Rx Group, LLC]

Updated Date: Dec 31, 2013 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

Response to "Understanding CYP2D6 and Its Role in Tamoxifen Metabolism".

Response to "Understanding CYP2D6 and Its Role in Tamoxifen Metabolism". Oncol Nurs Forum. 2014 Jan 1;41(1):12 Authors: Kaplan M, Mahon SM Abstract In light of the article "Understanding CYP2D6 and Its Role in Tamoxifen Metabolism" (Smith, 2013), we feel it imperative to comment on the recent, unexpected approval by the U.S. Food and Drug Administration (2013) of the selective serotonin reuptake inhibitor paroxetine as a nonhormonal treatment for menopausal hot flashes. Paroxetine is a strong inhibitor of CYP2D6, the same enzyme system that converts tamoxifen to its active form, endoxifen. Thus, women receiving tamoxifen therapy for hormone-positive breast cancer should be informed of the risk of reducing tamoxifen efficacy with concomitant use of paroxetine to treat their ...<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>

Spinal morphine but not ziconotide or gabapentin analgesia is affected by alternative splicing of voltage-gated calcium channel CaV2.2 pre-mRNA

Presynaptic voltage-gated calcium CaV2.2 channels play a privileged role in spinal level sensitization following peripheral nerve injury. Direct and indirect inhibitors of CaV2.2 channel activity in spinal dorsal horn are analgesic in chronic pain states. CaV2.2 channels represent a family of splice isoforms that are expressed in different combinations according to cell-type. A pair of mutually exclusive exons in the CaV2.2 encoding Cacna1b gene, e37a and e37b, differentially influence morphine analgesia. In mice that lack exon e37a, which is enriched in nociceptors, the analgesic efficacy of intrathecal morphine against noxious thermal stimuli is reduced. Here we ask if sequences unique to e37a influence: the development of abnormal thermal and mechanical sensitivity associated with perip...

Pregabalin-induced self-harm behavior - Tandon VR, Mahajan V, Gillani ZH, Mahajan A.

We report a case of pregabalin-induced self-inflicted multiple injuries on forearm after its contin... (Source: SafetyLit: All (Unduplicated))

Prevention and treatment of chemotherapy-induced peripheral neuropathy.

CONCLUSION: Calcium and magnesium infusions and venlafaxine are effective in preventing CIPN but are not routinely used because of concerns related to decreased chemotherapy efficacy. Adjunct treatment options for CIPN include a topical analgesic, a tricyclic antidepressant, an anticonvulsant, or an SNRI. Duloxetine is more effective than placebo in treating oxaliplatin- or paclitaxel-induced CIPN, is well tolerated, and should be considered to be a first-line treatment option for CIPN. PMID: 24352178 [PubMed - in process] (Source: American Journal of Health-System Pharmacy : AJHP)

Pharmacological Treatments of Non-Substance-Withdrawal Delirium: A Systematic Review of Prospective Trials.

CONCLUSIONS These promising results warrant further study with consideration of the methodological weaknesses and inconsistencies of studies to date. PMID: 24362367 [PubMed - as supplied by publisher] (Source: The American Journal of Psychiatry)

Differential pharmacological alleviation of oxaliplatin-induced hyperalgesia/allodynia at cephalic versus extra-cephalic level in rodents.

Authors: Michot B, Kayser V, Bastian G, Bourgoin S, Hamon M Abstract Previous data showed that neuropathic pain induced by mechanical lesion of peripheral nerves responds differently to alleviating drugs at cephalic versus extracephalic level. Because neuropathic pain evoked by anti-cancer drugs differs from that triggered by mechanical nerve lesion, we investigated whether differences between cephalic and extracephalic levels could also be characterized in rodents rendered neuropathic by treatment with the anti-cancer platinum derivative oxaliplatin. C57BL/6J mice received two injections and Sprague-Dawley rats three injections of oxaliplatin (10 mg/kg, i.p.) or its vehicle, with three days intervals. Supersensitivity to mechanical (von Frey filaments), cold (acetone drop) and ch...<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>

GABAPENTIN Capsule [Clinical Solutions Wholesale]

Updated Date: Dec 16, 2013 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

Treatment of hidradenitis supprurativa associated pain with nonsteroidal anti-inflammatory drugs, acetaminophen, celecoxib, gabapentin, pegabalin, duloxetine, and venlafaxine.

Authors: Scheinfeld N Abstract Hidradenitis Supprurativa is a painful dermatological condition. Although the pain of HS has unique aspects, the pain of HS pain shares common elements with essential pain, fibromyalgia, and pure neuropathic pain syndromes. Futhermore, depression plays an important role in the pain of HS. This paper reviews the potential for use of nonsteroidal anti-inflammatory drug (NSAIDS), acetaminophen, celecoxib, gabpentin, pregabalin, and the serotonin and norepinephrine reuptake inhibitors (SNRIs), duloxetine and venlafaxine, for treating HS related pain. No studies exist for pain control in HS. Initially, the pain of HS is treated medically e.g. oral rifampin and clindamycin or adalimumab to decrease inflammation, but an analysis of pain medications to treat ...

Gabapentin for refractory chronic cough

This randomised controlled trial from Australia reported on the efficacy of gabapentin in chronic refractory cough and investigated its role in modulating central sensitisation (CS) of the cough reflex. Recruitment of 62 patients was conducted over 2&nbsp;years. Fifty-two patients completed the trial. All were non-smokers with a cough of more than 8&nbsp;weeks&rsquo; duration and had negative investigation and trials of treatment for asthma, rhinitis, gastro-oesophageal reflux and respiratory tract infection. Participants were randomised to placebo or gabapentin for a 12-week period, with objective serial assessments of cough severity, sensitivity and quality of life. Dose range was 300&nbsp;&ndash;1800&nbsp;mg. Patient groups, although well matched for efficacy variables, did not reach th...

US high court leaves intact $142 million verdict against Pfizer

WASHINGTON (Reuters) - The U.S. Supreme Court on Monday left intact a $142 million jury verdict against Pfizer Inc over the marketing of the epilepsy drug Neurontin. (Source: Reuters: Health)

Confirmed: Gabapentin Improves Alcohol Dependence OutcomesConfirmed: Gabapentin Improves Alcohol Dependence Outcomes

The anticonvulsant gabapentin improves 2 sleep variables associated with alcohol-dependence relapse. Medscape Medical News (Source: Medscape Today Headlines)<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>

U.S. high court leaves intact $142 million verdict against Pfizer

WASHINGTON (Reuters) - The U.S. Supreme Court on Monday left intact a $142 million jury verdict against Pfizer Inc over the company's marketing of the epilepsy drug Neurontin. (Source: Reuters: Health)

Differential upregulation in DRG neurons of an őĪ2őī-1 splice variant with a lower affinity for gabapentin after peripheral sensory nerve injury

Summary: A minor őĪ2őī-1 splice-variant, (ő?A+Bő?C), with reduced affinity for gabapentin, is differentially upregulated in DRG neurons following ligation. This could influence the efficacy of gabapentin.Abstract: The őĪ2őī-1 protein is an auxiliary subunit of voltage-gated calcium channels, critical for neurotransmitter release. It is upregulated in dorsal root ganglion (DRG) neurons following sensory nerve injury, and is also the therapeutic target of the gabapentinoid drugs, which are efficacious in both experimental and human neuropathic pain conditions. őĪ2őī-1 has 3 spliced regions: A, B, and C. A and C are cassette exons, whereas B is introduced via an alternative 3‚?≤ splice acceptor site. Here we have examined the presence of őĪ2őī-1 splice variants in DRG neurons, and have found ...

Effects of epilepsy treatments on sleep architecture and daytime sleepiness: An evidence‚?źbased review of objective sleep metrics

Summary Sleep is considered restorative, and good quantity and quality sleep is required for memory consolidation and synaptic plasticity. Sleep disorders are common in patients with epilepsy. Poor sleep quality or quantity may worsen seizure control. On the other end, seizures and epilepsy may worsen the sleep quality and set a vicious cycle. In addition, antiepileptic drugs have an effect on sleep architecture. We performed a systemic literature review with a goal to evaluate the effect of antiepileptic drugs and nondrug treatments for epilepsy on sleep architecture to help better understand treatment effects, especially in patients with epilepsy and sleep problems. We searched PubMed and identified studies that evaluated objective sleep outcomes for an antiepileptic drug. We also search...

Glia and epilepsy: Experimental investigation of antiepileptic drugs in an astroglia/microglia co‚?źculture model of inflammation

In conclusion, we suggest that AEDs with antiinflammatory glial features are beneficial for seizures caused by persistent brain inflammation. (Source: Epilepsia)

Pharmacological Inhibition of Voltage-gated Ca(2+) Channels for Chronic Pain Relief.

Authors: Lee S Abstract Chronic pain is a major therapeutic problem as the current treatment options are unsatisfactory with low efficacy and deleterious side effects. Voltage-gated Ca2+ channels (VGCCs), which are multi-complex proteins consisting of őĪ1, ő≤, ő≥, and őĪ2őī subunits, play an important role in pain signaling. These channels are involved in neurogenic inflammation, excitability, and neurotransmitter release in nociceptors. It has been previously shown that N-type VGCCs (Cav2.2) are a major pain target. U.S. FDA approval of three Cav2.2 antagonists, gabapentin, pregabalin, and ziconotide, for chronic pain underlies the importance of this channel subtype. Also, there has been increasing evidence that L-type (Cav1.2) or T-type (Cav3.2) VGCCs may be involved in pain sign...<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>

Cardiac Repolarization With Gabapentin Enacarbil in a Randomized, Double-Blind, Placebo- and Active-Controlled, Crossover Thorough QT/QTc Study in Healthy Adults.

CONCLUSION: Single doses of GEn, up to 6000 mg, had no effect on cardiac repolarization in this thorough-QT study and are unlikely to cause clinically relevant QT prolongation in clinical use. Assay sensitivity was confirmed with moxifloxacin as an active control. ClinicalTrials.gov identifier: NCT01516372. PMID: 24290737 [PubMed - as supplied by publisher] (Source: Clinical Therapeutics)

Donepezil provides positive effects to patients treated with gabapentin for neuropathic pain: an exploratory study

ConclusionDonepezil may provide additional analgesia to neuropathic pain patients with insufficient pain relief from gabapentin as monotherapy. The promising results support controlled clinical trials of the drug combination. The usefulness of mixed‚?źeffects analysis in small‚?źscale trials and/or for data with high intersubject variability was also demonstrated. (Source: Acta Anaesthesiologica Scandinavica)

Can Mesenchymal Stem Cells and Novel Gabapentin-Lactam Enhance Maxillary Bone Formation?

Conclusions: Bone formation is initiated from the residual alveolar crest and along the implant. The elected mode of GBP-L application did not induce faster NBF. Alternate forms of application (eg, slow release or systemic administration) might clarify the controversial in vitro findings. (Source: Journal of Oral and Maxillofacial Surgery)

Gabapentin did not reduce morphine consumption, pain, or opioid-related side effects in total knee arthroplasty.

Authors: Zaffagnini S PMID: 24257668 [PubMed - in process] (Source: The Journal of Bone and Joint Surgery. American volume)

Table of Contents

Abstract Parity Final Rule Even Stronger than IFR, Protecting Residential Noncompliant Health Plan Example An Active Presence Online Can Counteract Negative Comments Who Must Provide Coverage under the MHPAEA Law ‚?? Not the Final Rule Focus on Recovery, Ongoing Stigma Problems for OTPs at AATOD New Casinos, New Problem Gamblers for New York NIAAA Trial Finds Promising Results for Gabapentin Walter Ginter Presents Advocate and Patient View at AATOD Briefly Noted Obituary Names in the News Coming up (Source: Alcoholism and Drug Abuse Weekly)<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>

Effect of melatonin and gabapentin on anxiety and pain associated with retrobulbar eye block for cataract surgery: A randomized double-blind study

Conclusion: The level of anxiety was significantly lower with both anxiolytic drugs compared to placebo. Furthermore, gabapentin decreased the pain and improved the sedation scores only during retrobulbar placement compared to the placebo. (Source: Indian Journal of Pharmacology)

Does 4-aminopyridine "beat" downbeat nystagmus?

The flocculus of cerebellum inhibits the vestibular nuclei and keeps the eyes steady during downward gaze. Disinhibition of the flocculus leads to slow upward drift of the eyes, followed by corrective downward saccade&mdash;the &lsquo;downbeat&rsquo;&mdash;hence the name &lsquo;downbeat&rsquo; nystagmus. Asymmetry in the vertical smooth pursuit pathway or, imbalance in the neural tone of the central connections of the vertical semicircular canals and otoliths can cause downbeat nystagmus. Idiopathic downbeat nystagmus, however, is the most common form. Historically, the therapeutic approach for downbeat nystagmus has focused on the compounds that affect serum pH or inhibitory neurotransmitters modulating the cell membrane function. Acetazolamide was traditionally used for the treatment of ...

Phantom Limb Pain: A Systematic Neuroanatomical‚?źBased Review of Pharmacologic Treatment

ConclusionsCurrently, the best evidence (level 2) exists for the use of IV ketamine and IV morphine for the short‚?źterm perioperative treatment of PLP and PO morphine for an intermediate to long‚?źterm treatment effect (8 weeks to 1 year). Level 2 evidence is mixed for the efficacy of perioperative epidural anesthesia with morphine and bupivacaine for short to long‚?źterm pain relief (perioperatively up to 1 year) as well as for the use of gabapentin for pain relief of intermediate duration (6 weeks). (Source: Pain Medicine)

Antiepileptic drugs for neuropathic pain and fibromyalgia - an overview of Cochrane reviews.

CONCLUSIONS: Clinical trial evidence supported the use of only gabapentin and pregabalin in some neuropathic pain conditions (painful diabetic neuropathy, postherpetic neuralgia, and central neuropathic pain) and fibromyalgia. Only a minority of people achieved acceptably good pain relief with either drug, but it is known that quality of life and function improved markedly with the outcome of at least 50% pain intensity reduction. For other antiepileptic drugs there was no evidence, insufficient evidence, or evidence of a lack of effect; this included carbamazepine. Evidence from clinical practice and experience is that some patients can achieve good results with antiepileptics other than gabapentin or pregabalin.There is no firm evidence to answer the important pragmatic questions about w...

Why Doctors Are Testing An Epilepsy Drug For Alcoholism

Gabapentin, a generic drug, appears to reduce alcohol cravings and ease sleeplessness and anxiety associated with withdrawal. But the drug hasn't been approved by the Food and Drug Administration to treat alcohol dependence, and there's no sign it will be anytime soon.&raquo; E-Mail This&nbsp;&nbsp;&nbsp;&nbsp; &raquo; Add to Del.icio.us (Source: NPR Health and Science)<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>

Table of Contents

Abstract Controlled trial finds ketamine exerts rapid antidepressant effects Fluoxetine, cognitive therapy both mitigate relapse in high‚?źrisk group Adverse reaction to antibiotic in patient receiving venlafaxine Adjunctive therapies in schizophrenia have little effect on cognition Postpartum hemorrhage shows higher incidence in antidepressant users Escitalopram has preventive effect in head and neck cancer patients Intermittent antipsychotic treatment not as effective as continuous Symptoms, not antipsychotics, linked to Alzheimer's admissions Semagacestat trial for Alzheimer's halted amid adverse events Gabapentin reduces opiate use during withdrawal protocol Approvals (Source: The Brown University Psychopharmacology Update)

Misuse of the GABA‚?źAnalogues Baclofen, Gabapentin and Pregabalin in the United Kingdom

(Source: British Journal of Clinical Pharmacology)

Patient demographics and health plan paid costs in CIDP

We examined demographics, prevalence of comorbidities, prescribed drugs, place of service, and mean annual health plan paid costs per patient. Results: From 6.5 million covered lives, 73 (56% men; mean age 47) met study entry criteria. The most prescribed therapies were intravenous immunoglobulin (IVIg) (26% of patients), gabapentin (26%), and prednisone (16%). The annual health plan paid cost was $56,953. Pharmacy cost was the major cost driver (57% of the total), and IVIg totaled 90% of the pharmacy costs. Discussion: Healthcare costs for CIDP patients are substantial, with a large burden in pharmacy utilization. Studies are needed to determine optimal long‚?źterm treatment strategies for CIDP, particularly related to IVIg. ¬© 2013 Wiley Periodicals, Inc. (Source: Muscle and Nerve)

Stretch-induced nerve injury: a proposed technique for the study of nerve regeneration and evaluation of the influence of gabapentin on this model.

Authors: Machado JA, Ghizoni MF, Bertelli J, Teske GC, Teske GC, Martins DF, Mazzardo-Martins L, Cargnin-Ferreira E, Santos AR, Piovezan AP Abstract The rat models currently employed for studies of nerve regeneration present distinct disadvantages. We propose a new technique of stretch-induced nerve injury, used here to evaluate the influence of gabapentin (GBP) on nerve regeneration. Male Wistar rats (300 g; n=36) underwent surgery and exposure of the median nerve in the right forelimbs, either with or without nerve injury. The technique was performed using distal and proximal clamps separated by a distance of 2 cm and a sliding distance of 3 mm. The nerve was compressed and stretched for 5 s until the bands of Fontana disappeared. The animals were evaluated in relation to functio...

Anticonvulsant Promising for Alcohol DependenceAnticonvulsant Promising for Alcohol Dependence

Gabapentin, a widely prescribed anticonvulsant used to treat epilepsy and neuropathic pain, is showing promise in the treatment of alcohol dependence. Medscape Medical News (Source: Medscape Today Headlines)<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>

Gabapentin Helps Alcoholics Stay on the Wagon (CME/CE)

(MedPage Today) -- Patients reporting alcohol dependence were better able to stay sober when treated with oral gabapentin (Neurontin) in a placebo-controlled trial, researchers said, although abstinence rates remained low. (Source: MedPage Today Neurology)

NIH-Funded Study Finds That Gabapentin May Treat Alcohol Dependence

Source: National Institute on Alcohol Abuse and Alcoholism - Related MedlinePlus Page: Alcoholism (Source: MedlinePlus Health News)

Clinical trial indicates gabapentin is safe and effective for treating alcohol dependence

(Scripps Research Institute) The generic drug gabapentin, which is already widely prescribed for epilepsy and some kinds of pain, appears to be safe and effective in the treatment of alcohol dependence. The finding comes from a 150-patient randomized, placebo-controlled, double blind clinical trial conducted by scientists at The Scripps Research Institute. (Source: EurekAlert! - Social and Behavioral Science)

Post-surgical pain syndromes: a review for the non-pain specialist.

CONCLUSIONS: Reduction of CPSP is a worthy long-term outcome for anesthesia providers to consider as they plan the perioperative care of their patients. More evidence is needed about the effect of currently used analgesics and other perioperative techniques on CPSP. PMID: 24185829 [PubMed - as supplied by publisher] (Source: Canadian Journal of Anaesthesia)

Outpatient management of alcohol withdrawal syndrome.

Authors: Muncie HL, Yasinian Y, Oge' L Abstract Approximately 2% to 9% of patients seen in a family physician's office have alcohol dependence. These patients are at risk of developing alcohol withdrawal syndrome if they abruptly abstain from alcohol use. Alcohol withdrawal syndrome begins six to 24 hours after the last intake of alcohol, and the signs and symptoms include tremors, agitation, nausea, sweating, vomiting, hallucinations, insomnia, tachycardia, hypertension, delirium, and seizures. Treatment aims to minimize symptoms, prevent complications, and facilitate continued abstinence from alcohol. Patients with mild or moderate alcohol withdrawal syndrome can be treated as outpatients, which minimizes expense and allows for less interruption of work and family life. Patients ...<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>

Effect of Mushroom Diet on Pharmacokinetics of Gabapentin in Healthy Chinese Subjects

ConclusionsThese data suggest that diet‚?źdrug pharmacokinetic interactions may occur during co‚?źexposure to gabapentin and mushroom constituents. However, as it does not affect the AUClast of gabapentin, it may not have clinically important consequences. Shiitake mushrooms can also be used as a source of ergothioneine for future clinical studies. (Source: British Journal of Clinical Pharmacology)

Clinical Characteristics and Medication Uses Among Fibromyalgia Patients Newly Prescribed Amitriptyline, Duloxetine, Gabapentin, or Pregabalin

ConclusionPatients who started 1 of the 4 common drugs for fibromyalgia similarly had multiple comorbidities and other fibromyalgia‚?źrelated medication use, but continued the treatment only for a short time. The dose of the 4 drugs was not increased in most patients during the followup period. (Source: Arthritis Care and Research)

Duloxetine Compared with Pregabalin for Diabetic Peripheral Neuropathic Pain Management in Patients with Suboptimal Pain Response to Gabapentin and Treated with or without Antidepressants: A Post Hoc Analysis

ConclusionsIn patients with DPNP inadequately treated with gabapentin without the concomitant use of antidepressants, switching to duloxetine instead of pregabalin may provide better pain reduction. Conversely, in nonresponders to gabapentin who are concomitantly using an antidepressant, switching to duloxetine or pregabalin may provide similar pain reductions. (Source: Pain Practice)

Letter to the Editor

We read with interest the article Inhibition of IL-6 signaling: a novel therapeutic approach to treating spinal cord injury pain by Guptarak et al. . The study showed that decreased paw withdrawal thresholds are correlated with interleukin-6 (IL-6) upregulation in lumbar segments below a spinal cord injury (SCI) in rats and are reversed after treatment with an IL-6 receptor antibody. Although the study generates interesting directions for future research, we are concerned about the interpretation that decreased paw withdrawal thresholds equate to mechanical allodynia and neuropathic pain. In rats, as well as in humans, hyperreflexia, spasms and increased muscle tone are seen as part of the spastic syndrome following SCI. The arguments used by the authors to translate their results to the c...

Comparative efficacy and tolerability of anti‚?źepileptic drugs for refractory focal epilepsy: systematic review and network meta‚?źanalysis reveals the need for long term comparator trials

ConclusionOf the wide range of AEDs licensed for the treatment of refractory epilepsy, sodium valproate, levetiracetam and gabapentin demonstrated the best balance of efficacy and tolerability. Until regulators mandate greater use of active comparator trials with longer term follow‚?źup, network meta‚?źanalysis provides the only available means to quantify these clinically important parameters. (Source: British Journal of Clinical Pharmacology)<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>

Nausea and the quest for the perfect anti-emetic.

Authors: Andrews PL, Sanger GJ Abstract The discovery of anti-emetic agents is reviewed to illustrate the large database (&gt;129,000 papers in PubMed) available for potential data mining and to provide a background to the shift in interest to nausea from vomiting. Research on nausea extends to identification of biomarkers for diagnosis/clinical trials and to understanding why nausea is such a common dose-limiting toxicity of diverse therapeutic agents. The lessons learned for translation from animals to humans, from the discovery of the anti-vomiting effects of 5-HT3 and NK1 receptor antagonists, is discussed in terms of the similarities between the emetic pathways and their pharmacology, and also in terms of the limitations of rodent models of "nausea" (pica, conditioned taste av...

Pharmacological treatment for pain in Guillain-Barré syndrome.

CONCLUSIONS: While management of pain in GBS is essential and pharmacotherapy is widely accepted as being an important component of treatment, this review does not provide sufficient evidence to support the use of any pharmacological intervention in people with pain in GBS. Although reductions in pain severity were found when comparing gabapentin and carbamazepine with placebo, the evidence was limited and its quality very low. Larger, well-designed RCTs are required to further investigate the efficacy and safety of potential interventions for patients with pain in GBS. Additionally, interventions for pain in the convalescent phase of GBS should be investigated. PMID: 24142399 [PubMed - as supplied by publisher] (Source: Cochrane Database of Systematic Reviews)

Anticonvulsants for fibromyalgia.

CONCLUSIONS: The anticonvulsant, pregabalin, demonstrated a small benefit over placebo in reducing pain and sleep problems. Pregabalin use was shown not to substantially reduce fatigue compared with placebo. Study dropout rates due to adverse events were higher with pregabalin use compared with placebo. Dizziness was a particularly frequent adverse event seen with pregabalin use. At the time of writing this review, pregabalin is the only anticonvulsant drug approved for treating FM in the US and in 25 other non-European countries. However, pregabalin has not been approved for treating FM in Europe. The amount and quality of evidence were insufficient to draw definite conclusions on the efficacy and safety of gabapentin, lacosamide and levetiracetam in FM. PMID: 24129853 [PubMed - as su...

Dermal Exposure to a Compounded Pain Cream Resulting in Severely Elevated Clonidine Concentration.

DISCUSSION: There are limited reports of topical clonidine toxicity, and to our knowledge, this case involves the highest concentration yet reported following clonidine overdose by any route of exposure. The severely elevated serum clonidine concentration found in our patient demonstrates the possibility of toxicity resulting from inappropriate use of such a product. At high serum concentrations, the pharmacodynamic effects of clonidine appear to cause significant peripheral alpha-1 adrenergic stimulation. Toxicologists should be aware of the increasing use of topical clonidine preparations for the treatment of neuropathic pain and the potential for toxicity. PMID: 24129834 [PubMed - as supplied by publisher] (Source: Journal of Medical Toxicology)

Gabapentin Alleviates Facet-Mediated Pain in the Rat Through Reduced Neuronal Hyperexcitability and Astrocytic Activation in the Spinal Cord

This study used a rat model of painful C6-C7 facet joint stretch, together with intrathecal administration of gabapentin, to investigate the effects of one aspect of spinal neuronal function on joint pain. Gabapentin or saline vehicle was given via lumbar puncture prior to and at 1 day after painful joint distraction. Mechanical hyperalgesia was measured in the forepaw for 7 days. Extracellular recordings of neuronal activity and astrocytic and microglial activation in the cervical spinal cord were evaluated at day 7. Gabapentin significantly (P = .0001) attenuated mechanical hyperalgesia, and the frequency of evoked neuronal firing also significantly decreased (P  (Source: The Journal of Pain)<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>

Gabapentin Coordination Networks: Mechanochemical Synthesis and Behavior under Shelf Conditions

Crystal Growth & DesignDOI: 10.1021/cg401187x (Source: Crystal Growth and Design)

A case of Zolpidem dependence successfully detoxified with gabapentin.

Authors: Fernandes WH, Pereira YD, O' Tereza S Abstract An elderly female patient with Zolpidem dependence, who was successfully detoxified using Gabapentin is reported. Gabapentin may be considered as an alternative in the detoxification of non-benzodiazepine hypnotics. PMID: 24082253 [PubMed - as supplied by publisher] (Source: Indian Journal of Psychiatry)

The Usual Treatment of Trigeminal Autonomic Cephalalgias

Trigeminal autonomic cephalalgias include cluster headache, paroxysmal hemicrania, and short‚?źlasting unilateral neuralgiform headache attacks with conjunctival injection, tearing, and rhinorrhea (SUNCT). Conventional pharmacological therapy can be successful in the majority of trigeminal autonomic cephalalgias patients. Most cluster headache attacks respond to 100% oxygen inhalation, or 6‚??mg subcutaneous sumatriptan. Nasal spray of sumatriptan (20‚??mg) or zolmitriptan (5‚??mg) are recommended as second choice. The bouts can be brought under control by a short course of corticosteroids (oral prednisone: 60‚?ź100‚??mg/day, or intravenous methylprednisolone: 250‚?ź500‚??mg/day, for 5 days, followed by tapering off the dosage), or by long‚?źterm prophylaxis with verapamil (at least 240‚??...

The Usual Treatment of Trigeminal Autonomic Cephalalgias.

Authors: Pareja JA, Alvarez M Abstract Trigeminal autonomic cephalalgias include cluster headache, paroxysmal hemicrania, and short-lasting unilateral neuralgiform headache attacks with conjunctival injection, tearing, and rhinorrhea (SUNCT). Conventional pharmacological therapy can be successful in the majority of trigeminal autonomic cephalalgias patients. Most cluster headache attacks respond to 100% oxygen inhalation, or 6‚??mg subcutaneous sumatriptan. Nasal spray of sumatriptan (20‚??mg) or zolmitriptan (5‚??mg) are recommended as second choice. The bouts can be brought under control by a short course of corticosteroids (oral prednisone: 60-100‚??mg/day, or intravenous methylprednisolone: 250-500‚??mg/day, for 5 days, followed by tapering off the dosage), or by long-term prop...

A Pediatric Case of Painful Legs and Moving Toes Syndrome

An 11-year-old girl presented with abnormal movements of her toes and feet. She had involuntary flexion, extension and adduction, abduction movements of her toes, and involuntary dorsiflexion of her feet ( and ; supplementary material associated with this article can be found in the online version at http://dx.doi.org/10.1016/j.pediatrneurol.2013.06.016). The movements occurred at rest and could not be voluntarily suppressed. The movements started a year before presentation in her left foot and gradually involved both feet. She also described simultaneous onset of cramping pain around her buttocks and thighs. It was nonradiating and worsened when she lay down. Magnetic resonance imaging scans of the brain and spine revealed an incidental syrinx at the C7 level and a lipoma at the filum te...<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>

Low single dose gabapentin does not affect prefrontal and occipital gamma-aminobutyric acid concentrations

Abstract: The ő≥-aminobutyric acid (GABA) system has been proposed as a target for novel antidepressant and anxiolytic treatments. Emerging evidence suggests that gabapentin (GBP), an anticonvulsant drug that significantly increases brain GABA levels, is effective in the treatment of anxiety disorders. The current study was designed to measure prefrontal and occipital GABA levels in medication-free healthy subjects after taking 0mg, 150mg and 300mg GBP. Subjects were scanned on a 3T scanner using a transmit-receive head coil that provided a relatively homogenous radiofrequency field to obtain spectroscopy measurement in the medial prefrontal (MPFC) and occipital cortex (OCC). There was no dose-dependent effect of GBP on GABA levels in the OCC or MPFC. There was also no effect on Glx, choli...

Is there a role for Gabapentin in preventing or treating pain following thoracic surgery?

A best evidence topic in cardiothoracic surgery was written according to a structured protocol. The question addressed was whether gabapentin, a commonly prescribed neuropathic analgesic and anticonvulsant, is safe and beneficial in patients with post-thoracotomy pain following thoracic surgery. Seventeen papers were identified using the search described below, and five papers presented the best evidence to reach conclusions regarding the issues of interest for this review. Side effects and complications as well as evidence of benefit, typically using various pain-scoring systems, were included in the assessment. The author, date and country of publication, patient group studied, study type, relevant outcomes, results and study weaknesses of the papers are tabulated. The systematic review ...

Episodic itch in a case of spinal glioma

Conclusion: Patients with intractable pruritus and dermatomal presentation ought to undergo neurological examination and spinal cord imaging. Thus, ongoing frustrating and sometimes even harmful treatment trials could be avoided. (Source: BMC Neurology)

[Lacosamide as an alternative in the treatment of post-surgery neuropathic pain in an allergic patient].

CONCLUSIONS. Lacosamide is a third-generation antiepileptic drug that has been proven to be effective, safe and with few side effects. It has been considered a good therapeutic option for the treatment of neuropathic pain in patients who are allergic to pregabalin. PMID: 24052442 [PubMed - in process] (Source: Revista de Neurologia)

P 204. Additive effect of repetitive transcranial magnetic stimulation and anticonvulants

Objective: The aim of our study was to reveal of rTMS and antiepileptic drugs (AEDs) interaction effects.Methods: The comparative analysis of anticonvulsive effects of rTMS combination with different AEDs (carbamazepine, valproic acid, topiramate and gabapentin) was performed. The experimental data was obtained at maximal electroshock test (MEST) on Wistar rats which took AED in minimal effective doses. RTMS with 1Hz frequency and difference intensities was performed by circular coil (Neuro-MS, Russia) at pike concentration of AEDs time. Absence of maximal tonic hind limb extension (MTHLE) and all seizure phases durations were estimated. Results of combined therapy groups were conferred with monotherapy (AED or rTMS only) and control group (n=10 in each group).Results: RTMS has additive ef...<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>

New Choices For Seasonal Flu Vaccines

WebMD Health News By Brenda Goodman, MA Reviewed by Michael W. Smith, MD Sept. 17, 2013 &#8212; It&#8217;s fall. The kids are back at school, college football rivalries are in high gear, and &#8212; oh, yeah &#8212; it&rsquo;s time to get a flu vaccine. In the past, flu protection basically boiled down to a choice between a shot or a sniff of a nasal spray. But this year there are new options. Some may protect you from additional strains of flu, while others make getting vaccinated a little easier. Read on to find out which may be best for you and your family. Trivalent Vaccines These are the traditional flu shots. They prime the immune system to fight three strains of flu viruses, two &#8220;A&#8221; strains and one &#8220;B&#8221; strain. Each year, the FDA updates the recipe to include ...

A Phase 2a, Randomized, Crossover Trial of Gabapentin Enacarbil for the Treatment of Postherpetic Neuralgia in Gabapentin Inadequate Responders

ConclusionsWhile the overall results demonstrated efficacy in a PHN population, the differences between treatment periods confound the interpretation. These findings could provide insight into future trial designs. (Source: Pain Medicine)

A review on antiepileptic drugs-dependent fatigue: Pathophysiological mechanisms and incidence.

Authors: Siniscalchi A, Gallelli L, Russo E, De Sarro G Abstract Fatigue represents a common side effect of several drugs, however, the underlying mechanisms have not been well identified. A depression of the central nervous system (CNS) and/or changes in peripheral processes have been associated with the development of fatigue. Antiepileptic drugs (AEDs), generally decreasing CNS excitability,are used in the treatment of seizures as well as other neurological and psychiatric diseases. Fatigue is certainly a common AEDs's side effect, although a high degree of variability exists depending on both patient's characteristics and the drug used. Here, we delineate the pathophysiological central and peripheral mechanisms by which AEDs may cause fatigue also reviewing the available clinic...

Gabapentin Withdrawal: Case Report in an Older Adult and Review of the Literature

(Source: Journal of the American Geriatrics Society)

C5 and C7 intramolecular hydrogen bonds stabilize the structure of N-pyrazinoyl-gabapentin (Pyr-Gpn-OH)IIIM communication number: IIIM/1573/2013.

2-{1-[(Pyrazin-2-ylformamido)methyl]cyclohexyl}acetic acid (Pyr-Gpn-OH), C14H19N3O3, is an N-protected derivative of gabapentin (Gpn). The compound crystallizes in the triclinic space group P\overline{1} and the molecular conformation is stabilized by intramolecular five- (C5) and seven-membered (C7) hydrogen-bonded rings. The packing of the molecules reveals intermolecular O‚??H...O and C‚??H...N hydrogen bonds, together with Ō?‚??Ō? interactions. (Source: Acta Crystallographica Section C)<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>

Nummular headache after trans-sphenoidal surgery: a referred pain-based headache syndrome.

We report a patient who suffered from a relapsing and remitting course of NH at the high parietal area and vertex shortly after resection for pituitary prolactinoma via a trans-sphenoidal approach. There was no focal trophic change or paresthesia but a mild allodynia in the painful area. The patient did not exhibit trigeminal sensory disorder or cranial trauma thoroughly. The pain responded well to gabapentin. Therefore, physicians should be aware of postoperative NH, which is amenable to treatment. The findings in our patient support a dual mechanism of NH and suggest that central NH is a form of referred pain. PMID: 23986431 [PubMed - as supplied by publisher] (Source: Neurologia i Neurochirurgia Polska)

Successful treatment of stiff person syndrome with sequential use of tacrolimus

Stiff person syndrome (SPS) is a rare neurological disease with features of an autoimmune disease. SPS is characterised by severe progressive muscle stiffness of the spine and lower extremities with superimposed muscle spasms triggered by external stimuli such as noise, touch and emotional distress.1 Patients with SPS respond to high doses of muscle relaxants, such as diazepam and baclofen, several anticonvulsants, and gabapentin. Previous studies have reported that several causal treatments with corticosteroids, plasmapheresis, intravenous immunoglobulin (Ig) and new immunomodulating agents can reduce stiffness and lower sensitivity to stimuli and stress in patients with SPS.2 3 Because SPS is a chronic disease, patients generally require long-term treatments, which may be effective but d...

P 204. Additive effect of repetitive transcranial magnetic stimulation and anticonvulants

Objective: The aim of our study was to reveal of rTMS and antiepileptic drugs (AEDs) interaction effects.Methods: The comparative analysis of anticonvulsive effects of rTMS combination with different AEDs (carbamazepine, valproic acid, topiramate and gabapentin) was performed. The experimental data was obtained at maximal electroshock test (MEST) on Wistar rats which took AED in minimal effective doses. RTMS with 1Hz frequency and difference intensities was performed by circular coil (Neuro-MS, Russia) at pike concentration of AEDs time. Absence of maximal tonic hind limb extension (MTHLE) and all seizure phases durations were estimated. Results of combined therapy groups were conferred with monotherapy (AED or rTMS only) and control group (n=10 in each group).Results: RTMS has additive ef...

Rationale and design of a multicenter randomized clinical trial of extended release gabapentin in provoked vestibulodynia and biological correlates of response

Conclusion: We will conduct the first multicenter RCT to confirm efficacy of an agent that is currently used in clinical practice for treating PVD. (Source: Contemporary Clinical Trials)

Nonoperative treatment for lumbar spinal stenosis with neurogenic claudication.

CONCLUSIONS: Moderate and high-quality evidence for nonoperative treatment is lacking and thus prohibits recommendations for guiding clinical practice. Given the expected exponential rise in the prevalence of lumbar spinal stenosis with neurogenic claudication, large high-quality trials are urgently needed. PMID: 23996271 [PubMed - as supplied by publisher] (Source: Cochrane Database of Systematic Reviews)

[Occipital neuralgia: clinical and therapeutic characteristics of a series of 14 patients].

CONCLUSIONS. In this series from a specialised headache unit, occipital neuralgia is an infrequent condition that mainly affects patients over 50 years of age. Given its poor response to preventive treatment, the full prolonged response to anaesthetic blockades must be taken into account. PMID: 23975524 [PubMed - in process] (Source: Revista de Neurologia)

Antiepileptic drugs and breastfeeding

Conclusions Although the current available advice on the use of AEDs during breastfeeding, given by different accredited sources, present some contradictions, most AEDs can be considered safe according to our review. (Source: Italian Journal of Pediatrics)

New-Onset Gastrointestinal Polyposis

Question: A 60-year-old man presented to the outpatient gastroenterology clinic with a 9-month history of diarrhea. The diarrhea started gradually, intermittent in course; he reported anywhere between 2 to 10 loose bowel movements a day, with a lot of mucous in the stool but no blood. This was associated with upper abdominal discomfort, bloating, early satiety, and nausea. He complained of significant fatigue and lost about 40 lbs during this period of illness. He complained of his fingernails and toenails becoming very brittle and eventually lost all of them, burning of the tongue, decreased taste sensation, hair loss, decreased libido, and development of skin hyperpigmentation over his thighs. The patient‚??s medical history is remarkable for hypertension, hyperlipidemia, osteoarthritis,...

Globus pharyngeus: effectiveness of treatment with proton pump inhibitors and gabapentin.

CONCLUSIONS: A majority of patients with globus pharyngeus can be helped by treating reflux or neuralgia. A trial of gabapentin should be considered for patients who do not respond or only partially respond to reflux management. PMID: 24027858 [PubMed - in process] (Source: The Annals of Otology, Rhinology, and Laryngology)<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>

Gabapentin add-on for drug-resistant partial epilepsy.

CONCLUSIONS: Gabapentin has efficacy as an add-on treatment in people with drug-resistant partial epilepsy. However, the trials reviewed were of relatively short duration and provide no evidence for the long-term efficacy of gabapentin beyond a three-month period. The results cannot be extrapolated to monotherapy or to people with other epilepsy types. PMID: 23888424 [PubMed - as supplied by publisher] (Source: Cochrane Database of Systematic Reviews)

High‚?źdose glucocorticoid to improve post‚?źoperative recovery in total hip and knee arthroplasty

ConclusionsThis PhD thesis render new knowledge by demonstrating ‚?? for the first time ‚?? detailed procedure‚?źspecific beneficial effects of a single pre‚?źoperative dose of MP, 125‚??mg IV, on acute post‚?źoperative analgesia in THA, and on acute post‚?źoperative analgesia and on other immediate recovery aspects in TKA. Noteworthy, these benefits were observed with MP added to a comprehensive multimodal oral analgesic regime consisting of paracetamol, celecoxib and gabapentin ‚?? and in TKA also to an intra‚?źoperative local infiltration analgesia regimen. However, current data in hip and knee surgery preclude firm safety conclusions, and call for large‚?źscale studies to definitively clarify the risk‚??benefit ratio, before final recommendations can be made. Also, the shortage of dose...

Clinical characteristics and medication uses among fibromyalgia patients newly prescribed amitriptyline, duloxetine, gabapentin or pregabalin

Conclusion: Patients who started one of the four common drugs for fibromyalgia similarly had multiple comorbidities and other fibromyalgia‚?źrelated drug use, but continued the treatment only for a short time. The dose of the four drugs was not increased in most patients during the follow‚?źup. ¬© 2013 American College of Rheumatology. (Source: Arthritis Care and Research)

A comparative study of efficacy and safety of gabapentin versus amitriptyline as coanalgesics in patients receiving opioid analgesics for neuropathic pain in malignancy

Conclusions: Amitriptyline may be a suitable alternative for management of neuropathic pain in cancer patients although gabapentin is widely used for this purpose. The lower cost of amitriptyline may favor patient compliance with lesser number of drop-outs. (Source: Indian Journal of Pharmacology)

Randomized, placebo-controlled pilot trial of gabapentin during an outpatient, buprenorphine-assisted detoxification procedure.

This pilot study examined the efficacy of the N-type calcium channel blocker gabapentin to improve outcomes during a brief detoxification protocol with buprenorphine. Treatment-seeking opioid-dependent individuals were enrolled in a 5-week, double-blind, placebo-controlled trial examining the effects of gabapentin during a 10-day outpatient detoxification from buprenorphine. Participants were inducted onto buprenorphine sublingual tablets during Week 1, were randomized and inducted onto gabapentin or placebo during Week 2, underwent a 10-day buprenorphine taper during Weeks 3 and 4, and then were tapered off gabapentin/placebo during Week 5. Assessments included thrice-weekly opioid withdrawal scales, vitals, and urine drug screens. Twenty-four individuals (13 male; 17 Caucasian, 3 African...<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>

A simple high-throughput method for determination of antiepileptic analogues of ő≥-aminobutiric acid in pharmaceutical dosage forms using microplate fluorescence reader.

Authors: Martinc B, Vovk T Abstract Pregabalin (PGB), gabapentin (GBP), and vigabatrin (VGB) are structural analogues of g-aminobutiric acid used for the treatment of different forms of epilepsy. Their analytical determination is challenging since these molecules have no significant ultraviolet or visible absorption. Several derivatization methods have been developed and used for their determination in bulk or pharmaceutical dosage forms. We aimed to develop a high- throughput method using a microplate reader with fluorescence detection and simple derivatization with fluorescamine. Obtained method involves derivatization step of only five minutes at room temperature and simultaneous measurements of 96 samples (őĽex 395, őĽem 476 nm) thus rendering excellent high-throughput analysis...

The long-term treatment of restless legs syndrome/Willis‚??Ekbom disease: evidence-based guidelines and clinical consensus best practice guidance: a report from the International Restless Legs Syndrome Study Group

Abstract: A Task Force was established by the International Restless Legs Syndrome Study Group (IRLSSG) to develop evidence-based and consensus-based recommendations for the long-term pharmacologic treatment of restless legs syndrome/Willis‚??Ekbom disease (RLS/WED). The Task Force reviewed the results of all studies of RLS/WED treatments with durations of 6months or longer presented at meetings over the past 2years, posted on Web sites of pharmaceutical companies, or published in peer-reviewed journals, asking the questions, ‚??What is the efficacy of this treatment in patients with RLS/WED?‚?Ě and ‚??What is the safety of this treatment in patients with RLS/WED?‚?ĚThe Task Force developed guidelines based on their review of 61 papers meeting inclusion criteria, and using a modified evide...

Sneddon's syndrome presenting with neuropathic pain.

Authors: Dag E, Gokce B, Kocak M Abstract A 55-year-old man was admitted to us with a sense of numbness, tingling, and burning in his feet and headache, characterized as a feeling of pressure all around his head, for 1 year and aggravated in the past 3 months. The patient's neurologic examination was normal and he had no other known diseases except for hypertension according to his medical history. During the examination, we recognized purplish lesions on the patient's body. His kidney, liver, and thyroid function test results and vitamin B12 levels were all normal. His hematocrit level was 41.8%, platelet value was 234,000 (150,000-500,000); and sedimentation rate was 9 mm/h (0-20). Electromyography was performed and results were found to be normal. The patient was diagnosed as ha...

Quick Facts About Neurontin / Gabapentin

This article covers basic information, warnings, common side effects, and a look at the controversy regarding the use of Neurontin in treating bipolar disorder. (Source: About.com Bipolar Disorder)

Brachioradial Pruritus: Mayo Clinic Experience over the Past Decade

ConclusionsBrachioradial pruritus presented most commonly in females and was observed over a wide age range. Although a third of patients with imaging studies had cervical abnormalities, the significance of these findings is unclear since neurologists did not find structural causes of BRP in most cases. Some treatments were more successful than others in treating BRP.This article is protected by copyright. All rights reserved. (Source: British Journal of Dermatology)<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>

Brachioradial Pruritus: Mayo Clinic Experience over the Past Decade.

CONCLUSIONS: Brachioradial pruritus presented most commonly in females and was observed over a wide age range. Although a third of patients with imaging studies had cervical abnormalities, the significance of these findings is unclear since neurologists did not find structural causes of BRP in most cases. Some treatments were more successful than others in treating BRP. This article is protected by copyright. All rights reserved. PMID: 23796379 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)

Gabapentin or pregabalin for the prophylaxis of episodic migraine in adults.

CONCLUSIONS: The pooled evidence derived from trials of gabapentin suggests that it is not efficacious for the prophylaxis of episodic migraine in adults. Since adverse events were common among the gabapentin-treated patients, it is advocated that gabapentin should not be used in routine clinical practice. Gabapentin enacarbil is not efficacious for the prophylaxis of episodic migraine in adults. There is no published evidence from controlled trials of pregabalin for the prophylaxis of episodic migraine in adults. PMID: 23797675 [PubMed - as supplied by publisher] (Source: Cochrane Database of Systematic Reviews)

Antiepileptics other than gabapentin, pregabalin, topiramate, and valproate for the prophylaxis of episodic migraine in adults.

CONCLUSIONS: Available evidence does not allow robust conclusions regarding the efficacy of antiepileptic drugs other than gabapentin, pregabalin, topiramate, and valproate in the prophylaxis of episodic migraine among adults. Acetazolamide, carisbamate, clonazepam, lamotrigine, oxcarbazepine, and vigabatrin were not more effective than placebo in reducing headache frequency. In one trial each, carbamazepine and levetiracetam were significantly superior to placebo in reducing headache frequency, and there was no significant difference in proportion of responders between zonisamide and active comparator. These three positive studies suffer from considerable methodological limitations. PMID: 23797674 [PubMed - as supplied by publisher] (Source: Cochrane Database of Systematic Reviews)

Long-term retention of lacosamide in a large cohort of people with medically refractory epilepsy: A single centre evaluation

Highlights: Summary: Lacosamide (LCM) is a recently licensed antiepileptic drug available in the UK since 2008. It is thought to act through modulation of sodium channel slow inactivation. Its efficacy and tolerability have been shown in several regulatory randomised controlled trials, but assessments of its performance in large naturalistic settings are rare. We assessed a large cohort of consecutive people who started LCM at a single tertiary epilepsy centre, from June 2008 to June 2011. Forty-five percent of the 376 people included were still taking LCM at last follow-up, with estimated retention was 62% at one year, 45% at two years and 35% at three years. Eighteen percent reported a period of improvement in terms of significant seizure reduction or seizure freedom of at least six mont...

Add-on therapy: When two are not better than one

Patients with diabetes mellitus are at risk of developing painful diabetic polyneuropathy, a common and disabling neuropathic pain condition. Establishing glycemic control is the first step of the treatment, but symptomatic pain management is still frequently needed. Recommended first- and second-line treatments are tricyclic antidepressants, serotonin-noradrenaline reuptake inhibitors (SNRIs), gabapentin, pregabalin, and opioids . However, as in many other chronic conditions, monotherapy rarely results in adequate disease control, and combination drug regimens are commonly used. Combination pharmacotherapy has several advantages. If 2 drugs with complementary pharmacological mechanisms exhibit synergistic or additive effects, combination therapy may provide greater pain relief with fewer ...

Neuropathic pain in cancer

Cancer-related neuropathic pain is common; it can be disease related or related to the acute or chronic effects of cancer treatment. For example, chemotherapy-induced peripheral neuropathy occurs in 90% of patients receiving neurotoxic chemotherapy. Cancer treatments have become more effective; patients are living longer with cancer and there are more cancer survivors. However, side-effects (particularly neuropathy) have become more problematic. The key to management of cancer-related neuropathy is a considered assessment, remembering not to miss the opportunity of reversing the cause of the pain with appropriate oncological management. An increasing range of oncological therapies are available, including radiotherapy, chemotherapy, hormonal therapy, or one of the evolving approaches (e.g....

Restless legs syndrome: pathophysiology and modern management

Restless legs syndrome (RLS) is a common sensory motor neurological disorder that is characterised by an irresistible urge to move the legs that significantly affects the quality of life of the patient. Prevalence in the general population is 5-25% and it is twice as prevalent in women as in men. RLS is the most common movement disorder in pregnancy with a fourfold increased risk of developing this disorder later in life. The pathophysiology of RLS is centred on dopaminergic dysfunction, reduced central nervous system iron, genetic linkages, or alteration in neurotransmitters such as hypocretins, endorphins levels and immune dysfunction and inflammatory mechanisms. With the emergence of new evidence, there are changes to the previous treatment recommendations for RLS. There is sufficient e...

Gabapentin Versus Chlordiazepoxide for Outpatient Alcohol Detoxification Treatment (July/August).

CONCLUSIONS:In ambulatory veterans with symptoms of alcohol withdrawal, gabapentin treatment resulted in significantly greater reduction in sedation (ESS) and a trend to reduced alcohol craving (PACS) by the end of treatment compared to chlordiazepoxide treatment. Although limited by the small sample size, the suggestion of reduction in sleepiness and less craving warrants replication of the study with a larger sample. PMID: 23780805 [PubMed - as supplied by publisher] (Source: The Annals of Pharmacotherapy)

Suit: Neurontin Marketed Illegally for Bipolar...

Not only does the lawsuit allege that Parke-Davis marketed Neurontin to physicians without FDA approval - but research studies say Neurontin is not effective for bipolar disorder after all. (Source: About.com Bipolar Disorder)<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>

Single centre 20 year survey of antiepileptic drug-induced hypersensitivity reactions.

Conclusion: Some hypersensitivity problems of epileptic patients were obviously related to antiepileptic treatment. Among AEDs, gabapentin, topiramate, levetiracetam, vigabatrin, and phenobarbital were not associated with skin lesions, although the number of patients in the case of the latter was small. PMID: 23744424 [PubMed - in process] (Source: Pharmacological Reports)

Oral gabapentin premedication for elderly patients undergoing intraocular surgery

Conclusions Hence, premedication with oral gabapentin in these elderly patients undergoing elective intraocular surgery produced intraoperative anxiolysis, decreased sedation, a modest decrease in IOPs and improved postoperative recovery. (Source: British Journal of Ophthalmology)

Synergism of lacosamide with established antiepileptic drugs in the 6‚?źHz seizure model in mice

The objective of this study was to determine the presence of such interactions by isobolographic analysis. MethodsThe anticonvulsant effect of LCM in combination with other AEDs including carbamazepine (CBZ), phenytoin (PHT), valproate (VPA), lamotrigine (LTG), topiramate (TPM), gabapentin (GBP), and levetiracetam (LEV) at fixed dose ratios of 1:3, 1:1, and 3:1, was evaluated in the 6‚?źHz‚??induced seizure model in mice. In addition, the impact of the combinations of LCM with the other AEDs on motor coordination was assessed in the rotarod test. Finally, AED concentrations were measured in blood and brain to evaluate potential pharmacokinetic drug interactions. Key FindingsAll studied AEDs produced dose‚?źdependent anticonvulsant effects against 6‚?źHz‚??induced seizures. Combinations of ...

What treatment works best for restless legs syndrome? Meta-analyses of dopaminergic and non-dopaminergic medications

Conclusion: This first meta-analysis of all RCTs for the pharmacological treatment of RLS provides evidence that, besides the well-defined efficacy of dopaminergic treatment, other treatments with different pharmacological principles show efficacy in small samples and may be well-tolerated alternatives for the treatment of RLS. In the group of anticonvulsants, only the trials performed with őĪ2őī ligands such as gabapentin, gabapentin enacarbil, and pregabalin showed good efficacy. This indicates a specific mechanism of action of these substances in RLS. The group of iron treatments consisted of a few trials with different compounds in oral and intravenous application form, respectively. For a more differentiated evaluation of the efficacy of iron treatments further studies are necessary. ...

Weighty matters

Antiepileptic drug therapy for epilepsy and mood disorders and pain management has been greatly enhanced and expanded by a growing array of therapeutic options. With choice comes the need for knowledge about the potential adverse effects of medications that may be taken lifelong. The adverse event profile of the established antiepileptic drug therapies is well established, but that of the newer agents continues to grow. Much of the known side effect profile comes from clinical trial data, which do not reflect the pattern or nature of use once an agent is marketed and available to the wider community. Weight gain with some antiepileptic drugs has been well described, and this potential side effect should be included in the informed decision making of all patients. While valproate, and to a...<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>

Assorted Medications sometimes used to treat...

Assorted medications somtimes used to treat anxiety - Buspar (buspirone), Neurontin (gabapentin), beta blockers Inderal (propranolol) (Source: About.com Mental Health)

Pregabalin versus gabapentin in the management of peripheral neuropathic pain associated with post-herpetic neuralgia and diabetic neuropathy: a cost effectiveness analysis for the Greek healthcare setting

Conclusions: Neuropathic pain carries a great disease burden for patients and society and, is also, associated with a significant economic burden. The treatment of pain associated with DPN and PHN with pregabalin is a cost-effective intervention for the social security in Greece compared to gabapentin. Thus, these findings need to be taken into consideration in the decision ‚?? making process when considering which therapy to use for the treatment of neuropathic pain. (Source: BMC Neurology)

FDA Says No to Nonhormonal Drug for Hot FlashesFDA Says No to Nonhormonal Drug for Hot Flashes

Depomed Inc's formulation of gabapentin for menopausal vasomotor symptoms fails to win FDA approval. FDA Approvals (Source: Medscape Today Headlines)

Intravenous moderate-dose bumetanide continuous infusion and severe musculoskeletal pain

We present a rare adverse side effect of moderate-to-high dose bumetanide continuous infusion in a 72year old Hispanic woman with a history of three-vessel coronary artery disease (CAD), heart failure (HF) with reduced ejection fraction, type 2 diabetes and stage III chronic kidney disease. The patient had been hospitalized for dyspnea and volume retention in the setting of progressive acute on chronic renal failure with oliguria. Trials of high-dose (160‚??240mg) fractionated bolus doses of intravenous furosemide were attempted in the first 48 to 72h with minimal urine output (10‚??20cm3/h). Metolazone was added to her regimen without appreciable incremental diuretic effect. She was then transitioned to bumetanide continuous infusion 1mg/h to augment diuresis. Within 12h of initiation, th...

Treatment of neuropathic pain in acute intermittent porphyria with gabapentin.

Authors: Lin TC, Lai SL, Hsu SP, Ro LS PMID: 23735466 [PubMed - as supplied by publisher] (Source: J Formos Med Assoc)

Cyclic (alternate day) vertical deviation‚??possible forme fruste of ocular neuromyotonia

Conclusions: On the basis of the response of these patients to membrane-stabilizing medications and the behavior noted as the cycle broke each day, we propose that cyclic vertical strabismus and ocular neuromyotonia may be related conditions with similar underlying physiology. (Source: Journal of AAPOS)

Major depression after withdrawing dopamine agonists in two patients with restless legs syndrome and impulse control disorders

An 84-year-old man with no psychiatric history had a multifactorial (i.e., family history, renal insufficiency, sensory distal polyneuropathy) case of restless legs syndrome (RLS) of 20years‚?? duration. Gabapentin and codeine did not improve RLS but bromocriptine, then pramipexole 0.7mg did. Because he developed augmentations and impulse control disorders (ICD) (e.g., teleshopping of antique books, sexual advances to his niece), we switched him from pramipexole to fentanyl overnight, which alleviated RLS symptoms. Three weeks later, he began to feel deeply sad and apathetic; he experienced a loss of interest and pleasure. The depression was not alleviated by citalopram, and moclobemide (a monoamine oxidase inhibitor) exacerbated RLS. After 10months of major apathy and sadness, we started ...

Transport of gabapentin by LAT1 (SLC7A5).

Authors: Dickens D, Webb SD, Antonyuk S, Giannoudis A, Owen A, Rädisch S, Hasnain SS, Pirmohamed M Abstract Gabapentin is used in the treatment of epilepsy and neuropathic pain. Gabapentin has high and saturable permeability across the BBB, but no mechanistic studies underpinning this process have been reported. The aim of the current study was to investigate the transport of gabapentin in a model of the BBB, identify the important drug transporter(s) and to use mathematical modelling to quantify the processes involved. A human brain endothelial cell line (hCMEC/D3) was utilised as an in-vitro model of the BBB. Uptake of radiolabeled gabapentin into cells in the presence of chemical inhibitors, siRNA or overexpressed drug transporters of interest was investigated. Gabapentin was d...

A Systematic Review of the Utility of Anticonvulsant Pharmacotherapy in the Treatment of Vulvodynia Pain

ConclusionAlthough some vulvodynia‚?źafflicted patients derive symptom relief from anticonvulsants, there is, as yet, insufficient evidence to support the recommendation of anticonvulsant pharmacotherapy in the treatment of vulvodynia. Additional investigations, employing randomized controlled trials, are warranted. Leo RJ. A systematic review of the utility of anticonvulsant pharmacotherapy in the treatment of vulvodynia pain. J Sex Med **;**:**‚??**. (Source: The Journal of Sexual Medicine)<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>

Gabapentin Therapy of Hiccups (June).

CONCLUSIONS:Gabapentin has a similar body of evidence as other pharmacotherapeutic agents used to treat hiccups. Gabapentin is well tolerated and should be considered as a second-line agent in selected patients. PMID: 23673537 [PubMed - as supplied by publisher] (Source: The Annals of Pharmacotherapy)

The efficacy of gabapentin in children of partial seizures and the blood levels

Abstract: Aim: To evaluate the long-term efficacy of gabapentin (GBP) and usefulness of measurement of the blood level for the observation of patients that have partial seizures.Methods: Thirty patients (20 effective cases and 10 ineffective cases) treated with GBP for the localization related epilepsy had their peak blood levels of GBP. The levels were measured seven time points, one, 6, 12, 18, 24, 30, and 36month after the start of medication. The efficacy of GBP was evaluated at one month after the initiation of medication and every year for 3years, based on the R Ratio and the degree of improvement for the paroxysmal strength and length.Results: GBP levels were higher in the effective cases than the levels in the ineffective cases 6months after and 1year after the initiation of medica...

HORIZANT (Gabapentin Enacarbil) Tablet, Extended Release [XenoPort Inc.]

Updated Date: May 1, 2013 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

Gabapentin does not improve multimodal analgesia outcomes for total knee arthroplasty: a randomized controlled trial.

CONCLUSION: Gabapentin 600 mg po given preoperatively followed by 200 mg po every eight hours for two days has no effect on postoperative morphine consumption, pain scores, patient satisfaction, or length of hospital stay. This trial is registered at ClinicalTrials.gov NCT01307202. PMID: 23479393 [PubMed - as supplied by publisher] (Source: Canadian Journal of Anaesthesia)

[Anesthesiological acute pain therapy in Germany : Telephone-based survey].

CONCLUSIONS: Since 1999 the number of hospitals that have implemented an APS has risen from 36.1¬†% to 64.2‚??%. The lack of consistent documentation of the OPS¬†8-919 will probably not increase the likelihood that it will become redeemable in the near future. Certain therapy methods, such as EA and PCA were still well established with oral therapy gaining in significance. The uncertainty regarding limits for coagulation values before removal of an epidural catheter could perhaps be reduced by a statement from the German Society of Anesthesia and Intensive Care. PMID: 23670579 [PubMed - in process] (Source: Der Anaesthesist)<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>

Management of Refractory Epilepsy

The term refractory epilepsy is utilized in veterinary medicine to describe a condition in which an animal with epilepsy fails to attain satisfactory seizure control or suffers intolerable side effects despite appropriate therapy with conventional antiepileptic drugs. Refractory epilepsy is an important problem in small animal practice as it occurs in approximately one-third of dogs with epilepsy. Consequently, there is much interest in identifying ways to more effectively treat this population of animals. More than a dozen new antiepileptic drugs have been approved for humans over the last 2 decades, and several of these drugs, including gabapentin, zonisamide, levetiracetam, and pregabalin, have been evaluated for the treatment of refractory seizures in veterinary patients. Nonmedical me...

Oral gabapentin premedication for elderly patients undergoing intraocular surgery.

CONCLUSIONS: Hence, premedication with oral gabapentin in these elderly patients undergoing elective intraocular surgery produced intraoperative anxiolysis, decreased sedation, a modest decrease in IOPs and improved postoperative recovery. PMID: 23620421 [PubMed - as supplied by publisher] (Source: The British Journal of Ophthalmology)

Pregnancy outcomes following gabapentin use: Results of a prospective comparative cohort study

Conclusion: Our results suggest that although this sample size is not large enough to make any definitive conclusions, and there was no comparator group treated with other antiepileptic drugs, gabapentin use in pregnancy does not appear to increase the risk for major malformations. This finding and the increased risk for low birth weight and preterm birth require further investigation. (Source: Neurology)

A Randomized, Double-Blind, Placebo-Controlled Trial to Assess the Efficacy and Safety of Gabapentin Enacarbil in Subjects With Neuropathic Pain Associated With Postherpetic Neuralgia (PXN110748)

Abstract: Gabapentin enacarbil (GEn) is an actively transported prodrug of gabapentin that provides sustained, dose-proportional exposure to gabapentin. This randomized, double-blind, parallel-group, placebo-controlled study evaluated the safety and efficacy of 3 different maintenance doses of oral GEn in subjects with postherpetic neuralgia. Adults with a 24-hour average pain intensity score of ‚?•4.0 received GEn 1,200 mg, 2,400 mg, 3,600 mg, or placebo for 14 weeks (including a 1-week up-titration, 12-week maintenance, and 1-week taper). The primary endpoint was change from baseline to end of maintenance treatment in mean 24-hour average pain intensity score. The intent-to-treat population consisted of 371 subjects (GEn 1,200 mg = 107, 2,400 mg = 82, 3,600 mg = 87, placebo¬†=¬†95). With...

GABAPENTIN (Gabapentin) Capsule [PD-Rx Pharmaceuticals, Inc.]

Updated Date: Apr 17, 2013 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>

Cocrystals of gabapentin with C-alkylresorcin[4]arenes

CrystEngComm, 2013, Accepted ManuscriptDOI: 10.1039/C3CE40441B, CommunicationHarshita Kumari, Jin Zhang, Loredana Erra, L Barbour, Carol Deakyne, Jerry L AtwoodThe synthesis of cocrystals of gabapentin with resorcin[4]arenes with different tail lengths, C-hexylresorcin[4]arene and C-propylresorcin[4]arene is reported. The structural elucidations of the two cocrystals show differences in packing arrangements and...The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - CrystEngComm latest articles)

An open trial of pregabalin as an acute and maintenance adjunctive treatment for outpatients with treatment resistant bipolar disorder

Conclusions: The results of this preliminary open study suggest that pregabalin is a safe and effective acute and maintenance adjunctive treatment for a significant number of treatment-resistant outpatients with any type of BPD. It appears to have mood stabilizing and antidepressant properties in addition to antimanic effects. Similar studies using a double-blind, randomly controlled design would be useful to confirm the reliability and validity of the results of this study. (Source: Journal of Affective Disorders)

QD Gabapentin Lessens After-Shingles Pain

(MedPage Today) -- FORT LAUDERDALE, Fla. -- Gastroretentive gabapentin treatment helped more than half of patients achieve relief from postherpetic neuralgia pain (PHN), or after-shingles pain, in a "real-world clinical practice," researchers said here. (Source: MedPage Today Neurology)

A Stochastic Optimization approach for the design of Individualized Dosage Regimens

Quantitative methods for individualizing and optimizing the dosage regimen and clinically monitoring each patient are desirable to insure that each patient can obtain effective therapeutic benefit while minimizing undesirable side effects. This is of special concern for medicines that are expensive or whose toxic side effects are severe (e.g., oncological agents). The optimal dosage regimen for an individual is a combination of dose amount and/or dosing interval (i.e., time between doses) which minimizes the risk that the drug exposure deviates from the desired therapeutic window. The therapeutic window is defined as the range of drug exposure (e.g., blood concentration, area under the curve concentration‚?źtime) which is below a threshold defining an acceptable toxic side effect and above...

Pharmacological Treatment Patterns in Neuropathic Pain‚??Lessons from Swedish Administrative Registries

ConclusionsTreatment initiation of currently available drugs indicated for neuropathic pain less frequently lead to long‚?źterm treatment in clinical practice compared with clinical trial, and few try more than one drug. We suggest our findings to be indications of a need for better routines in diagnosing patients to ascertain optimal treatment and follow‚?źup. (Source: Pain Medicine)<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>

Effect of a Preoperative Gabapentin on Postoperative Analgesia in Patients with Inflammatory Bowel Disease Following Major Bowel Surgery: A Randomized, Placebo‚?źControlled Trial

ConclusionsThis study examined the effect of a single preoperative administration of gabapentin in patients with IBD undergoing major bowel surgery. Our results suggest a single preoperative oral dose of gabapentin 600¬†mg does not reduce postoperative pain scores, opioid consumption, or opioid‚?źrelated side effects. (Source: Pain Practice)

Court upholds $142 million verdict against Pfizer over Neurontin

(Reuters) - A federal appeals court said Pfizer Inc should pay about $142 million to cover costs for the marketing and prescribing of epilepsy drug Neurontin for unapproved uses, a practice that has also earned it a hefty criminal fine. (Source: Reuters: Health)

Temporohyoid osteoarthropathy in two young horses

Two cases of temporohyoid osteoarthropathy (THO) in young Australian horses are described. The pathogenesis of THO is yet to be fully elucidated, but current theories include extension of infection from otitis media or interna to the temporohyoid joint or a primary but non‚?źinfectious degenerative condition within the temporohyoid joint. The young age of the horses and the unilateral distribution suggested an infectious aetiology. Both horses partially responded to treatment with broad‚?źspectrum antimicrobial and anti‚?źinflammatory drugs with concurrent management of ulcerative keratitis. The management of violent head shaking in one horse included the administration of gabapentin, an anticonvulsant known to have antihyperalgesic effects and reduce neuropathic pain. (Source: Australian ...

Impact of a Pregabalin Step Therapy Policy Among Medicare Advantage Beneficiaries

ConclusionAfter controlling for differences in age and comorbidity burden between the groups, implementation of a pregabalin ST restriction was associated with increased disease‚?źrelated pharmacy costs and decreased total medical costs; however, there was no net difference in total healthcare cost or total pharmacy cost. (Source: Pain Practice)

Non-hormonal interventions for hot flushes in women with a history of breast cancer.

CONCLUSIONS Clonidine, SSRIs and SNRIs, gabapentin and relaxation therapy showed a mild to moderate effect on reducing hot flushes in women with a history of breast cancer. PMID: 23657521 [PubMed - in process] (Source: Sao Paulo Medical Journal)<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>

Oral gabapentin suppresses pentylenetetrazole-induced seizure-like behavior and cephalic field potential in adult zebrafish.

We report the effect of orally administered gabapentin (GBP) on pentylenetetrazole (PTZ)-induced seizure-like activity in adult zebrafish. Zebrafish were pretreated with vehicle or GBP using a novel method of precise oral administration, followed by an intraperitoneal administration of PTZ. Behavioral assessment was carried out using locomotion-based video-tracking analysis and seizure score assignment using visual observation. Cephalic field potential recordings of the zebrafish brain were conducted using an electrical data acquisition system. Orally administered GBP significantly suppressed the seizure-like locomotor activity and strong slow-wave (~3Hz) activity in the cephalic field potential caused by PTZ. This work is the first report of the activity of an orally delivered anticonvuls...

Repeated Use of Subcutaneous Levetiracetam in a Palliative Care Patient

We present the case of a patient for whom levetiracetam was used subcutaneously, with clinical benefit and without significant complications. (Source: Journal of Pain and Symptom Management)

Mystery Case:Superior oblique myokymia due to vascular compression of the trochlear nerve

A 37-year-old man with episodic oscillopsia for 3 months showed intermittent torsional-vertical oscillation of the left eye (video on the Neurology&reg; Web site at www.neurology.org). MRI revealed an attachment between left trochlear nerve and left superior cerebellar artery in the quadrigeminal cistern (figure). Gabapentin 600 mg twice a day ameliorated the ocular oscillation and oscillopsia. (Source: Neurology)

Inhibition of IL-6 signaling: A novel therapeutic approach to treating spinal cord injury pain

Summary: Suppression of IL-6 signaling in a rat model of contusion spinal cord injury (SCI) with clinically available IL-6-R antibody abolishes SCI pain by restoring glutamate transporter levels.Abstract: To characterize the contribution of interleukin-6 (IL-6) to spinal cord injury pain (SCIP), we employed a clinically relevant rat contusion model of SCIP. Using Western blots, we measured IL-6 levels in lumbar segments (L1-L5), at the lesion site (T10), and in the corresponding lumbar and thoracic dorsal root ganglia (DRG) in 2 groups of similarly injured rats: (a) SCI rats that developed hind-limb mechanical allodynia (SCIP), and (b) SCI rats that did not develop SCIP. Only in SCIP rats did we find significantly increased IL-6 levels. Immunocytochemistry showed elevated IL-6 predominantl...

Disturbances in slow-wave sleep are induced by models of bilateral inflammation, neuropathic, and postoperative pain, but not osteoarthritic pain in rats

Summary: Bilateral inflammatory, nerve, skin-incision, but not osteoarthritic injuries caused a ‚??‚??pain‚??‚??-induced sleep disturbance in rats. This objective, non-evoked, assay demonstrated efficacy of reference analgesics at doses that did not affect normal sleep.Abstract: Preclinical assessment of pain has typically relied on measuring animal responses to evoked stimulation. Because of inherent limitations of these assays, there is a need to develop measures of animal pain/discomfort that are objective, not experimentally evoked, and mimic the human condition. Patients with chronic pain manifest a variety of co-morbidities, one of which is disturbances in sleep. We used electroencephalography to objectively assess 4 rat models of pain (inflammatory/complete Freund‚??s adjuvant [CFA]...<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>

Adjunctive treatment of acute mania: a clinical overview.

CONCLUSION: The available placebo-controlled randomized clinical trials support adjunctive therapy combining lithium or valproate with olanzapine, risperidone, haloperidol or quetiapine. The additional increment of antimanic efficacy of these combinations over monotherapy was similar in magnitude to that seen for the same agents as monotherapy in comparison with placebo. These additive benefits enhanced the tolerability of adverse effects sufficiently to allow a higher proportion of subjects receiving combination therapies to complete the studies than monotherapy treated patients. The available data has several shortcomings and the available studies are inadequate to conclusively determine whether combination treatment is more efficacious than monotherapy when used by subjects naive to bot...

Lamotrigine and antiepileptic drugs as mood stabilizers in bipolar disorder.

CONCLUSION: The AED are a heterogeneous group of medications with differential spectrum of efficacy in the treatment of bipolar disorder. PMID: 15833097 [PubMed - indexed for MEDLINE] (Source: Acta Psychiatrica Scandinavica Supplementum)

The pharmacokinetics and effects of meloxicam, gabapentin, and flunixin in postweaning dairy calves following dehorning with local anesthesia

In this study, we compared the pharmacokinetic parameters and effect of preemptive analgesics administered to calves subjected to dehorning with local anesthesia. Holstein steers were randomly assigned to receive one of the following treatments per os (PO) or intravenously (IV) (n¬†=¬†8/group): meloxicam (1¬†mg/kg PO), gabapentin (15¬†mg/kg PO), meloxicam (1¬†mg/kg), and gabapentin (15¬†mg/kg) PO, flunixin (2.2¬†mg/kg IV), or a placebo. Plasma drug, haptoglobin, substance P (SP) concentrations, serum cortisol concentrations, ocular thermography, mechanical nociceptive threshold (MNT), and average daily gain (ADG) were evaluated. Data were analyzed using mixed‚?źeffects models and noncompartmental pharmacokinetic analysis. Meloxicam, gabapentin, and meloxicam with gabapentin at the present ...

Use of a soluble epoxide hydrolase inhibitor as an adjunctive analgesic in a horse with laminitis

ConclusionsInhibition of sEH with t‚?źTUCB was associated with a significant improvement in pain scores in one horse with laminitis whose pain was refractory to the standard of care therapy. No adverse effects were noticed. Future studies evaluating the analgesic and protective effects of these compounds in painful inflammatory diseases in animals are warranted. (Source: Veterinary Anaesthesia and Analgesia)

Effects of gabapentin on pain and opioid consumption after abdominal hysterectomy.

CONCLUSION: &lt;‚Ā?span&gt; 1200 mg gabapentin reduced postoperative pain and the need for opioids, and enabled earlier ambulation of the patient. Significant side effects were not observed. PMID: 23662292 [PubMed - in process] (Source: Pain Research and Management)<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>

Effect of gabapentin pretreatment on propofol consumption, hemodynamic variables, and postoperative pain relief in breast cancer surgery.

CONCLUSION: Preoperative administration of gabapentin reduced intraoperative propofol requirements and postoperative analgesic consumption in breast cancer patients undergoing total mastectomy. PMID: 23711599 [PubMed - in process] (Source: Acta Anaesthesiologica Taiwanica)

An Important Phase 2 in MigraineAn Important Phase 2 in Migraine

A new phase 2 trial evaluates the safety and efficacy of gabapentin enacarbil for migraine prophylaxis. Medscape Neurology (Source: Medscape Today Headlines)

Gabapentin: Delusional parasitosis in an elderly patient: case report

(Source: Reactions)

An observational descriptive study of the epidemiology and treatment of neuropathic pain in a UK general population

Conclusion: The UK incidence of diagnosed PHN has increased with the incidence of back-pain and post-operative pain unclear. While use of licenced antiepileptics increased, prescribing of therapy with little evidence of efficacy in neuropathic pain is still common and consequently treatment was often not in-line with current guidance. (Source: BMC Family Practice)

Implications and mechanism of action of gabapentin in neuropathic pain.

Authors: Kukkar A, Bali A, Singh N, Jaggi AS Abstract Gabapentin is an anti-epileptic agent but now it is also recommended as first line agent in neuropathic pain, particularly in diabetic neuropathy and post herpetic neuralgia. őĪ2őī-1, an auxillary subunit of voltage gated calcium channels, has been documented as its main target and its specific binding to this subunit is described to produce different actions responsible for pain attenuation. The binding to őĪ2őī-1 subunits inhibits nerve injury-induced trafficking of őĪ1 pore forming units of calcium channels (particularly N-type) from cytoplasm to plasma membrane (membrane trafficking) of pre-synaptic terminals of dorsal root ganglion (DRG) neurons and dorsal horn neurons. Furthermore, the axoplasmic transport of őĪ2őī-1 subun...<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>

[Correspondence] Gabapentin for refractory chronic cough

Techniques for the assessment of cough have substantially improved in recent years, and include cough-specific quality-of-life scales and objective 24-h ambulatory cough counting techniques. We were therefore disappointed that Nicole Ryan and colleagues (Nov 3, p 1583) chose to only collect 1 h of objective monitoring data in their study. We believe this is a retrograde step in the design of studies to assess antitussives. (Source: LANCET)

[Correspondence] Gabapentin for refractory chronic cough ‚?? Authors' reply

Short-duration cough recording was done during the patient's visit. This recording involved capsaicin challenge, which accounts for the higher than normal cough frequencies reported. We kept measurements consistent by recording each participant to the same C5 level, at which point the cough recording was terminated. This result confirms that cough frequency fell during treatment, even when the cough reflex was chemically stimulated. We chose short cough recordings during scheduled participant visits to reduce further hospital visits. (Source: LANCET)

Chronic cough management: dealing with a sensation of mucus in the throat.

The cough‚?źrelated laryngeal sensation of mucus in the throat (SMIT) is usually overlooked because it is not reflected by physiological examinations or cough‚?źspecific questionnaires. Our results suggested that SMIT can predict the presence of fungal colonization in chronic cough patients. We propose that, next to ‚??cough‚?Ě or ‚??sputum,‚?Ě SMIT may become the third key clinical symptom for predicting the efficacy of antifungal therapy in chronic cough patients. Ryan and colleagues 1 recently reported gabapentin to be a novel antitussive with a beneficial effect against symptoms of central reflex sensitization, the latter of which is considered to be a potential mechanism underlying chronic cough. Their study showed that subjects with central sensitization (CS), including abnormal lary...<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>

Patient Demographics and Health Plan Paid Costs in CIDP (PD1.007)

CONCLUSIONS: Annual health care costs for CIDP are substantial with a large cost burden in pharmacy utilization. IVIg (FDA approved for CIDP) is the primary cost driver. With the emphasis on the rational use of health care resources, studies are needed to determine optimal long-term treatment strategies for CIDP, particularly with regard to IVIg.Supported by: An American Brain Foundation - Myasthenia Gravis Foundation of America Clinician Scientist Development Award (Dr. Guptill).Disclosure: Dr. Guptill has received personal compensation for activities with UCB Pharma as a consultant. Dr. Bromberg has received personal compensation for activities with Accordant Health Services, Grifols, Inc., Avanir Pharmaceuticals, and Walgreens. Dr. Bromberg has received research support from KNOPP. Dr. ...

Poor Carbamazepin Response in Patients with Classical Trigeminal Neuralgia and Polytherapy Treatment Options (P01.088)

CONCLUSIONS: Although carbamazepine alone is described as an effective prophylactic option in NT patients, in this terciary hospital series it was effective in monotherapy for less that 30% of patients. The polytherapy may be necessary for the refractory patients and periciazine should be considered in association with carbamazepine.Disclosure: Dr. Martinez has nothing to disclose. Dr. Nunes has nothing to disclose. Dr. de Vasconcellos has nothing to disclose. Dr. Alvim has nothing to disclose. Dr. da Costa has nothing to disclose. (Source: Neurology)

Compression of Lateral Antebrachial Cutaneous Nerve (LACN) in Waitresses (P01.128)

CONCLUSIONS: We described three cases of LACN compression from sharp edges of heavy trays with typical symptoms and abnormal electrophysiological studies and improvement with avoiding persistent direct compression and analgesics. We propose the lack of adequate fatty tissue in antecubital fossa probably contributed to compression of LACN. None of our patient required surgical treatment.Disclosure: Dr. Patel has nothing to disclose. Dr. Vishnubhakat has nothing to disclose. (Source: Neurology)

A Tale of Two Restless Sisters (P02.067)

CONCLUSIONS: Rasagiline was well tolerated during the follow-up. We suggest that Rasagiline could represent a useful adjunct therapeutic option in the treatment of RLS.Disclosure: Dr. Alvarez has received personal compensation for activities with Teva Neurosciences, US World Meds, Pfizer Inc, Forrest Pharmaceuticals, and Medtronic. Dr. Grogan has received personal compensation for activities with US Worldmeds as a speaker. (Source: Neurology)

Photosensitive Facial Dystonia as the First Manifestation of Dopa Responsive Dystonia (P02.071)

CONCLUSIONS: Dopa responsive dystonia can present with facial dystonia and photosensitivity years before development of foot dystonia. Facial dystonia and photosensitivity also respond well to dopa treatment.Disclosure: Dr. Safarpour has nothing to disclose. Dr. Sorokin has nothing to disclose. Dr. Jabbari has received research support from Allergan, Inc., Merz Pharma, and Ipsen. (Source: Neurology)<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>

Neurotonia/Myokymia in Ulnar Nerve Innervated Muscles and Response to Onabotulinumtoxin A (P02.230)

CONCLUSIONS: BotxA can be used in symtomatic neurotonia / myokymia secondary to defective accomodation of peripheral intramuscular nerve with good response and eventual recovery of the clinical / EMG findings.Disclosure: Dr. Baruah has nothing to disclose. Dr. Baruah has nothing to disclose. (Source: Neurology)

Neuromyotonia: Clinical, Electrophysiological and Immunological Findings of 4 Cases (P02.244)

CONCLUSIONS: The diagnosis of neuromyotonia is accomplished primarily through clinical and electrophysiological findings. Electromyography often confirms diagnosis by the presence of neuromyotonic discharges. The dosage of anti-CKVD has a low sensitivity for the diagnosis of disease. The association with autoimmune diseases can be observed, as described in this series.Disclosure: Dr. Scola has received personal compensation for activities with Merck Serono as scientific advisor board. Dr. Paranhos has nothing to disclose. Dr. Lorenzoni has nothing to disclose. Dr. Kay has nothing to disclose. Dr. Vincent has received personal compensation for activities with Athena Diagnostics. Dr. Vincent has received royalty payments from Athena Diagnostics. Dr. Werneck has nothing to disclose. (Source: ...

An Atypical Case of an SCN9A Mutation with Global Motor Delay and Erythromelalgia (P03.018)

CONCLUSIONS: We present the first case of global motor delay and erythromelalgia associated with an SCN9A mutation. The gross motor delay might be attributed to the extreme pain episodes or to a developmental perturbation of sensory-motor integration.Disclosure: Dr. Meijer has nothing to disclose. Dr. Vanasse has received personal compensation for activities with Janssen as a speaker. Dr. Vanasse has received research support from L'Institut de recherche Yves Ponroy. Dr. Nizard has nothing to disclose. Dr. Robitaille has nothing to disclose. Dr. Rossignol has nothing to disclose. (Source: Neurology)

Anti-NMDA Receptor Encephalitis with PSH: An Under-Recognized Association with Treatment Implications? (P03.028)

CONCLUSIONS: We believe that the autonomic instability associated with anti-NMDA receptor encephalitis may often be PSH. PSH often goes unrecognized in patients outside of the setting of TBI, thus specific PSH management strategies may be overlooked in other illnesses. Anti-NMDA receptor encephalitis may represent the functional companion to the structural lesion encountered in TBI. Recognition of PSH in this setting is important to guide the management of the autonomic instability, but may also have mechanistic implications.Disclosure: Dr. Takahashi has nothing to disclose. Dr. Hinson has received research support from the American Brain Foundation. Dr. Bourdette has received personal compensation for activities with Biogen Idec, Serono, and Teva Neurosciences for speaking and serving as ...

Transversus abdominis plane block or subcutaneous wound infiltration after open radical prostatectomy: a randomized study

ConclusionNeither TAP block nor wound infiltration with ropivacaine improved a basic multimodal analgesic regimen with paracetamol, ibuprofen and gabapentin after ORRP. (Source: Acta Anaesthesiologica Scandinavica)<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>

Gabapentin reduces preoperative anxiety and pain catastrophizing in highly anxious patients prior to major surgery: a blinded randomized placebo-controlled trial.

CONCLUSIONS: Administration of gabapentin 1,200 mg prior to surgery reduces preoperative NRS anxiety scores and pain catastrophizing scores and increases sedation prior to entering the operating room. These results suggest that gabapentin 1,200 mg may be a treatment option for patients who exhibit high levels of preoperative anxiety and pain catastrophizing; however, the sedative properties of the medication and the possibility of delayed postoperative discharge in the elective ambulatory population need to be considered. PMID: 23377862 [PubMed - as supplied by publisher] (Source: Canadian Journal of Anaesthesia)

Adult-Onset NREM Parasomnia with Hypnopompic Hallucinatory Pain: A Case Report

We report the case of a 43-year-old woman presenting with nocturnal episodes of pain and screaming during sleep starting at age 30. There was no childhood or family history of parasomnia. The events had gradually become more frequent over the years, occurring in the first half of the night within 2 h of sleep onset. There were no triggers, and she had partial amnesia for the events. A diagnosis of adult-onset sleep terrors was made on clinical grounds and supported polysomnographically. Seizures and periodic limb movements were excluded as triggering factors. There was some mild sleep disordered breathing (predominantly non-desaturating hypopnea with a propensity for REM sleep of debatable significance). Imaging of the brain and spine and neurophysiological investigations ruled out lesions...

NEURONTIN (Gabapentin) Capsule [REMEDYREPACK INC. ]

Updated Date: Feb 1, 2013 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

Intrathecal gabapentin increases interleukin-10 expression and inhibits pro-inflammatory cytokine in a rat model of neuropathic pain.

We examined the possible anti-inflammatory mechanisms of gabapentin in the attenuation of neuropathic pain and the interaction between the anti-allodynic effects of gabapentin and interleukin-10 (IL-10) expression in a rat model of neuropathic pain. The anti-allodynic effect of intrathecal gabapentin was examined over a 7-day period. The anti-allodynic effects of IL-10 was measured, and the effects of anti-IL-10 antibody on the gabapentin were assessed. On day 7, the concentrations of pro-inflammatory cytokines and IL-10 were measured. Gabapentin produced an anti-allodynic effect over the 7-day period, reducing the expression of pro-inflammatory cytokines but increasing the expression of IL-10 (TNF-őĪ, 316.0 ¬Ī 69.7 pg/mL vs 88.8 ¬Ī 24.4 pg/mL; IL-1ő≤, 1,212.9 ¬Ī 104.5 vs 577.4 ¬Ī 97.1 pg/...

Guillain-barre syndrome.

Authors: Walling AD, Dickson G Abstract Guillain-Barré syndrome consists of a group of neuropathic conditions characterized by progressive weakness and diminished or absent myotatic reflexes. The estimated annual incidence in the United States is 1.65 to 1.79 per 100,000 persons. Guillain-Barré syndrome is believed to result from an aberrant immune response that attacks nerve tissue. This response may be triggered by surgery, immunizations, or infections. The most common form of the disease, acute inflammatory demyelinating polyradiculoneuropathy, presents as progressive motor weakness, usually beginning in the legs and advancing proximally. Symptoms typically peak within four weeks, then plateau before resolving. More than one-half of patients experience severe pain, and about t...<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>

Pharmacological interventions for phantom limb pain.

CONCLUSIONS: Although there is lack of evidence-based consensus guidelines for the pharmacological management of phantom limb pain, we recommend tricyclic antidepressants, gabapentin, tramadol, opioids, local anaesthetics and N-methyl-D-aspartate receptor antagonists as the rational options for the treatment of phantom limb pain. PMID: 23422122 [PubMed - in process] (Source: Chinese Medical Journal)

Mandatory Palliative Care Education for Surgical Residents: Initial Focus on Teaching Pain Management

Conclusions The surgical residents stated that it was a meaningful course through which they gained practical knowledge on palliative care and that the experience would change their approach to home care. (Source: Japanese Journal of Clinical Oncology)

Comparative Efficacy and Tolerability of Antiepileptic Drugs for Refractory Focal Epilepsy Systematic Review and Network Meta‚?źAnalysis reveals the need for long‚?źterm comparator trials

ConclusionOf the wide range of AEDs licensed for the treatment of refractory epilepsy, sodium valproate, levetiracetam, and gabapentin demonstrated the best balance of efficacy and tolerability. Until regulators mandate greater use of active‚?źcomparator trials with longer term follow‚?źup, network meta‚?źanalysis provides the only available means to quantify these clinically important parameters. (Source: British Journal of Clinical Pharmacology)

Differences in Reporting of Analyses in Internal Company Documents Versus Published Trial Reports: Comparisons in Industry-Sponsored Trials in Off-Label Uses of Gabapentin

Conclusions Descriptions of analyses conducted did not agree between internal company documents and what was publicly reported. Internal company documents provide extensive documentation of methods planned and used, and trial findings, and should be publicly accessible. Reporting standards for randomized controlled trials should recommend transparent descriptions and definitions of analyses performed and which study participants are excluded. Please see later in the article for the Editors' Summary (Source: PLoS Medicine)

GABAPENTIN (Gabapentin ) Capsule [Ranbaxy Pharmaceuticals Inc.]

Updated Date: Jan 28, 2013 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>

Androgen deprivation therapy: evidence‚?źbased management of side effects

Conclusion Despite significant improvement in management strategies for the side effects of ADT, the best way of preventing side effects is to use ADT only when it is absolutely indicated. (Source: BJU International)

Flu Deaths ‚??Unpredictable‚??

WebMD Medical News By Daniel J. DeNoon Reviewed by Laura J. Martin, MD Aug. 26, 2010 &ndash; U.S. deaths from flu range from about 3,000 to about 50,000 per year, the CDC now calculates. The new numbers come from analysis of the last 31 flu seasons by CDC medical officer David Shay, MD, MPH and colleagues. For years, the CDC has been estimating the annual flu toll at about 36,000 flu-related deaths per year. But that average came from the years 1990-1999. The H3N2 type A flu bug dominated eight of those nine flu seasons &#8212; and the Shay study finds that H3N2 seasons are nearly three times as deadly as H1N1 type A or type B seasons. So how many people really die of flu in an average flu season? &#8220;There are very few average seasons,&#8221; Shay said at a news teleconference. &#8220...

Suicidality associated with antiepileptic drugs: Implications for the treatment of neuropathic pain and fibromyalgia

Antiepileptic drugs (AEDs) have a prominent role in the treatment of several types of chronic pain. Gabapentin and pregabalin are recommended as first-line treatments for various neuropathic pain conditions, carbamazepine and oxcarbazepine are commonly used in trigeminal neuralgia, and certain AEDs are considered second- or third-line treatments for neuropathic pain . In addition, pregabalin is recommended for fibromyalgia , and topiramate and valproic acid are considered first-line treatments for migraine prophylaxis . (Source: Pain)

Bupropion/gabapentin overdose: Burst suppression, seizures and cardiovascular disorders: case report

(Source: Reactions)

Gabapentin/phenytoin/valproate: Toxic epidermal necrolysis in a child: case report

(Source: Reactions)<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>

Neurologist practice patterns in treatment of muscle cramps in Canada

Recently an article provided patient perspectives on therapies and perceived effectiveness in preventing muscle cramps. However, there are few studies evaluating physicians' point of view in the management of this common symptom. In our study, we studied physician practice patterns in the treatment of muscle cramps by surveying a group of neurologists in Canada. We demonstrated that most physicians use a combination of pharmacological and non-pharmacological methods in treating muscle cramps. The most commonly used medications are baclofen, quinine and gabapentin, of which baclofen and quinine were reported to be the most tolerated. (Source: Journal of Foot and Ankle Research)

A Rational Approach to the Management of Chronic Migraine

About 2% of the adult population has chronic migraine with only 20% diagnosed with this disorder. Those with medication overuse may improve with withdrawal of overuse medications. The intravenous dihydroergotamine regimen usually produces short‚?źterm benefit for those with medically refractory chronic migraine. OnabotulinumtoxinA and topiramate have shown efficacy in large placebo‚?źcontrolled randomized trials. Sodium valproate, gabapentin, tizanidine, amitriptyline, fluoxetine, zonisamide, and possibly memantine may be alternative or possibly combined treatment options but with lesser levels of evidence supporting their use. Preliminary evidence suggests that nerve blocks might be beneficial. Acupuncture, biofeedback, relaxation therapy, and cognitive behavioral therapy might be of bene...

The role of the larynx in chronic cough.

Authors: Cobeta I, Pacheco A, Mora E Abstract Cough lasting more than 8 weeks is considered chronic. If the classic causes of chronic cough have been discarded, vagus nerve sensory disturbances are currently considered the most important etiological cause. Patients with chronic cough of laryngeal origin have associated symptoms such as globus, dysphagia, dysphonia, dyspnoea and/or stridor. These patients are more likely to have paradoxical vocal fold movement. There is a higher cough reflex sensibility and neuropathic laryngeal response, mainly caused by viral infection or reflux. The cough associated with reflux has 2 mechanisms: Exposure to acid in the distal oesophagus (gastroesophageal reflux) and microaspiration of oesophageal contents into the larynx and tracheo-bronchial tre...

Gabapentin Overdose in a Military Beneficiary

(Source: Military Medicine)

Persistent hyperalgesia in the Cisplatin-treated mouse as defined by threshold measures, the conditioned place preference paradigm, and changes in dorsal root Ganglia activated transcription factor 3: the effects of gabapentin, ketorolac, and etanercept.

CONCLUSIONS: Cisplatintreated mice display allodynia and an activation of DRG activated transcription factor 3, which is paralleled by its effects on behavior in the CPP system, wherein gabapentin, but not ketorolac, in the presence of the cisplatin polyneuropathy, is positively rewarding, confirming that this neuropathy is an aversive (painful) state that is ameliorated by gabapentin. PMID: 23223118 [PubMed - in process] (Source: Anesthesia and Analgesia)<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>

A rational approach to the management of chronic migraine.

Authors: Evans RW Abstract About 2% of the adult population has chronic migraine with only 20% diagnosed with this disorder. Those with medication overuse may improve with withdrawal of overuse medications. The intravenous dihydroergotamine regimen usually produces short-term benefit for those with medically refractory chronic migraine. OnabotulinumtoxinA and topiramate have shown efficacy in large placebo-controlled randomized trials. Sodium valproate, gabapentin, tizanidine, amitriptyline, fluoxetine, zonisamide, and possibly memantine may be alternative or possibly combined treatment options but with lesser levels of evidence supporting their use. Preliminary evidence suggests that nerve blocks might be beneficial. Acupuncture, biofeedback, relaxation therapy, and cognitive beha...

Analgesic Efficacy and Safety of Medical Therapy Alone vs Combined Medical Therapy and Extraoral Glossopharyngeal Nerve Block in Glossopharyngeal Neuralgia

ConclusionThis study found that patients in both the groups had significantly lower pain intensities, improved pain relief, and reduced pain interference with QOL, which was especially evident on fourth visit (2 months) after the initiation of treatment regimen. Both were safe and well tolerated. The study advocates rational polypharmacy approach (oral and block) in difficult to treat painful conditions. Further controlled trials are warranted to further define the impact of such a combination therapy. (Source: Pain Medicine)

Antiepileptic drugs (AEDs) during pregnancy and risk of congenital jaw and oral malformation

Abstract In the United States, an estimate of 1.3 million women suffering from epilepsy are in their childbearing age. Potential teratogenicity of antiepileptic drugs (AEDs) is of concern to these women considering pregnancy since discontinuing pharmacotherapy during pregnancy may not be advised due to the risk of seizures that may be dangerous to the mother as well as the fetus. Using a Relational Online Analytical Processing (ROLAP) software licensed by Simultek, we searched for medications reported for congenital jaw and oral cavity malformation on the FDA Adverse Event Reporting System (AERS), a voluntary adverse event reporting program that contains over 55 million adverse event reports of medical products in the U.S. Our results indicate that various forms of valproic acid and more i...

Current options and perspectives in the treatment of diabetic.

Authors: V√°rkonyi T, Putz Z, Keresztes K, Martos T, Lengyel C, Stirban A, Jermendy G, Kempler P Abstract We aimed to summarise recent advances in the therapy of diabetic neuropathy. Although all therapeutic choices in the treatment of diabetes mellitus itself are based on clear pathophysiological basis, this approach is less present in the treatment of the "forgotten complication", diabetic neuropathy. As part of pathogenetic oriented treatment, the role of glycemic control and cardiovascular risk factors are reviewed. The mode of action of benfotiamine is based on inhibition of key alternative pathways, including the polyol, hexosamine, protein-kinase-C pathways, and inhibition of advanced glycation end products formation, just as on activation of transketolase. Alpha-lipoic-acid...

Psychosomatic factors in pruritus

Abstract: Pruritus and psyche are intricately and reciprocally related, with psychophysiological evidence and psychopathological explanations helping us to understand their complex association. Their interaction may be conceptualized and classified into 3 groups: pruritic diseases with psychiatric sequelae, pruritic diseases aggravated by psychosocial factors, and psychiatric disorders causing pruritus. Management of chronic pruritus is directed at treating the underlying causes and adopting a multidisciplinary approach to address the dermatologic, somatosensory, cognitive, and emotional aspects. Pharmcotherapeutic agents that are useful for chronic pruritus with comorbid depression and/or anxiety comprise selective serotonin reuptake inhibitors, mirtazapine, tricyclic antidepressants (ami...<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>

A Review of Analgesic Compounds Used in Food Animals in the United States

Extralabel drug use for pain relief in the United States is regulated under the Animal Medicinal Drug Use Clarification Act. Agents that may provide analgesia in livestock include local anesthetics, nonsteroidal antiinflammatory drugs, opioids, őĪ2-agonists, and N-methyl-d-aspartate receptor antagonists. The challenges associated with providing pain relief in food animals and the salient pharmacokinetic and pharmacodynamic features of the analgesic compounds that could potentially be used in livestock are reviewed. The potential use of novel agents such as bicarbonate, magnesium, ethanol, and gabapentin to augment analgesia is also discussed. (Source: Veterinary Clinics of North America: Food Animal Practice)

Gabapentin Efficacy in Reducing Nighttime Awakenings in Premenopausal Women: A Class Effect of GABAergic Medications or Unique Property of Gabapentin Only?

(Source: Journal of Clinical Sleep Medicine : JCSM)

Calcitonin for phantom limb pain in a pregnant woman.

Conclusion A reduction in the frequency of PLP attacks and a lessening of pain intensity were observed after administration of calcitonin (salmon) by i.v. infusion in a pregnant patient. Calcitonin therapy was not associated with any apparent long-term adverse effects to the patient or infant. PMID: 23230038 [PubMed - in process] (Source: American Journal of Health-System Pharmacy : AJHP)

Effect of high-dose preoperative methylprednisolone on recovery after total hip arthroplasty: a randomized, double-blind, placebo-controlled trial

Conclusions MP 125 mg i.v. before surgery added to a multimodal oral analgesic regime did not reduce time to meet functional discharge criteria after THA, but improved analgesia for the first 24 h. (Source: British Journal of Anaesthesia)

Anticonvulsant action of indazole

Summary: Here we report that indazole is characterized as a potential anticonvulsant, inhibiting pentylenetetrazole-, electroshock- and strychnine-induced convulsions in mice (ED50's: 39.9, 43.2 and 82.4mg/kg, respectively) but not bicuculline- and picrotoxin-induced convulsions. The median toxic dose (TD50) of indazole was 52.3mg/kg by the minimal motor impairment test. Therefore, nontoxic doses produced anticonvulsant activity against pentylenetetrazole- and electroshock-induced seizures. Indazole (50mg/kg) had no effect on spontaneous activity but induced hypothermia. It also inhibited the metabolism of dopamine and 5-hydroxytryptamine in the brain in vivo and the activities of monoamine oxidase A and B in vitro, with IC50 values of 20.6őľM and 16.3őľM, respectively. However, these inhi...<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>

Presentation of adult mitochondrial epilepsy

Conclusions: Adult mitochondrial epilepsy appears to be less frequent than previously believed but the prevalence strongly depends on patient selection. Mitochondrial epilepsy is most frequently ‚??structural/metabolic‚?Ě. AEDs recommended for mitochondrial epilepsy include levetiracetam, lamotrigine, gabapentin and lacosamide. The outcome of mitochondrial epilepsy may be more favourable if mitochondrion-toxic AEDs are avoided. Only if non-mitochondrion-toxic AEDs are ineffective, mitochondrion-toxic AEDs may be used. (Source: Seizure: European Journal of Epilepsy)

Efficacy of gabapentin for treatment of adults with phantom.

CONCLUSIONS: Given the results of these trials, oral gabapentin in patients aged 18 years or older may decrease phantom limb pain. A strong recommendation for the effectiveness of gabapentin in phantom limb pain cannot be ascertained until more methodologically sound studies are executed in this population. PMID: 23232019 [PubMed - in process] (Source: The Annals of Pharmacotherapy)

Clinical Inquiry: Do venlafaxine and gabapentin control hot flashes in women with a history of breast cancer?

Authors: Sarkissian A, Neher JO, Singh R, St Anna L Abstract Venlafaxine reduces hot flashes more than placebo in women with a history of breast cancer; adverse effects include dry mouth and constipation. PMID: 23313996 [PubMed - in process] (Source: The Journal of Family Practice)

How do you switch between pregabalin and gabapentin for neuropathic pain, and vice versa?

Source: Regional Drug and Therapeutics Centre Area: Evidence &#62; Medicines Q & A Both gabapentin and pregabalin were originally developed as antiepileptic drugs. Both agents are also licensed for use in neuropathic pain. &#160; The mechanism of action is similar for pregabalin and gabapentin. Both drugs bind to the ?2? subunit of voltage-gated calcium channels. Gabapentin has nonlinear pharmacokinetics, meaning careful titration of dose is required, whereas pregabalin possesses linear pharmacokinetics, which mean dosing regimes are more straightforward. &#160; Pregabalin is recommended as a first-line treatment option for neuropathic pain by the National Institute for Health and Clinical Excellence. This recommendation was seen as controversial at the time of publication of the ...

Collagen antibody‚??induced arthritis evokes persistent pain with spinal glial involvement and transient prostaglandin dependency

ConclusionCAIA represents a multifaceted model for studies exploring the mechanisms of pain induced by inflammation in the articular joint. Our findings of a time‚?źdependent prostaglandin and spinal glial contribution to antibody‚?źinduced pain highlight the importance of using appropriate disease models to assess joint‚?źrelated pain. (Source: Arthritis and Rheumatism)<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>

Investigating Gabapentin Polymorphism Using Solid-State NMR Spectroscopy.

Authors: Dempah KE, Barich DH, Kaushal AM, Zong Z, Desai SD, Suryanarayanan R, Kirsch L, Munson EJ Abstract Solid-state NMR spectroscopy (SSNMR), coupled with powder X-ray diffraction (PXRD), was used to identify the physical forms of gabapentin in samples prepared by recrystallization, spray drying, dehydration, and milling. Four different crystalline forms of gabapentin were observed: form I, a monohydrate, form II, the most stable at ambient conditions, form III, produced by either recrystallization or milling, and an isomorphous desolvate produced from desolvating the monohydrate. As-received gabapentin (form II) was ball-milled for 45¬†min in both the presence and absence of hydroxypropylcellulose (HPC). The samples were then stored for 2¬†days at 50¬įC under 0% relative humid...

Intended and unintended consequences of the gabapentin off-label marketing lawsuit among patients with bipolar disorder

Source: Journal of Clinical Psychiatry Area: Evidence &#62; Medicines Management &#62; References Objective: The number of lawsuits accusing pharmaceutical companies of off-label marketing has risen in recent years. &#160;The impact of such lawsuits on drug prescribing and spending has not been examined. &#160;We evaluated a nationwide sample to determine whether the US$430 million gabapentin off-label marketing lawsuit and accompanying media coverage affected gabapentin market share, substitution of other scientifically substantiated and unsubstantiated anticonvulsants, and anticonvulsant spending of US Medicare/Medicaid patients diagnosed with bipolar disorder. Method: Using a national 5% sample of Medicare recipients linked to Medicaid claims, we used an interrupted times series desi...

DTB update on drug treatment of neuropathic pain: antiepileptics and other drugs

Source: DTB Area: Evidence &#62; Disease Focused Reviews Part 2 of the Drug and Therapeutics Bulletin (DTB) update on the treatment of neuropathic pain discusses the use of antiepileptic drugs and other analgesics (part 1 dealt with antidepresssants- see link). Treatments covered include: &#160; .&#160;Gabapentin and pregabalin .&#160;Carbamazepine .&#160;Opioids .&#160;Tramadol .&#160;Topical capsaicin .&#160;Topical lidocaine .&#160;Combination treatment &#160; For the management of chronic neuropathic pain there is limited availability of &#160; The paucity of high-quality clinical trials of sufficient duration is noted and the lack of head-to-head clinical trials means that many recommendations are based on indirect comparisons and health economic analyses that...

Why are antiepileptic drugs used for nonepileptic conditions?

Summary Antiepileptic drugs (AEDs) are used to treat various nonepileptic central nervous system (CNS) disorders, both in neurology and psychiatry. Most AEDs have multiple mechanisms of action (MOAs), which include modulation of ő≥‚?źaminobutyric acid (GABA)ergic and glutamatergic neurotransmission, and alteration of voltage‚?źgated ion channels or intracellular signaling pathways. These MOAs may explain the efficacy of AEDs in the treatment of bipolar disorder and neuropathic pain. Bipolar disorder and epilepsy have some common features, such as their episodic nature and associated kindling phenomena, which led to the regulatory approval and use of the AEDs carbamazepine (CBZ), valproic acid (VPA), and lamotrigine (LTG) in the treatment of bipolar disorder. A major limitation for the deve...

Epileptic seizure abolition with aromatase inhibition

Case history A 61-year-old woman had long-standing epilepsy since age 19. The most frequent seizure episodes were characterised by vacancy lasting seconds. She also had episodes involving perception of a strange feeling and lip smacking followed by tonic spasm of hands. Her average seizure frequency was 5&ndash;8 per month (93/year; range 83&ndash;142/year). Her husband had kept a meticulous record of her seizure frequency for the last 24&nbsp;years (figure 1). Electroencephalography showed temporal involvement and CT brain scan did not show any focal lesion. MRI performed with an epilepsy protocol did not show any evidence of mesial temporal sclerosis. She took different antiepileptic drugs (AED) as monotherapy or combination treatment without much success. The latest prescribed combinati...<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>

Antiepileptic drug use in Austrian nursing home residents

Abstract: Purpose: Currently around 30% of all newly developed seizures are diagnosed in persons older than 65 years. Five to 17% of nursing home-residents take antiepileptic drugs. The aim of our study was to analyze the type and frequency of prescribed antiepileptic drugs, as well as their indication, co-morbidities and co-medications in institutionalized elderly in Austria.Methods: This was a retrospective, cross-sectional study, which included all residents of the seven public nursing homes in Innsbruck, Austria. The data of 828 probands were extracted from the charts at site and maintained anonymously. The data collection was followed by descriptive statistics.Key findings: 70 (8.5%; 26 M/44 F) of the 828 (192 M/636 F) residents took at least one antiepileptic medication. In 51.5% the...

Once-Daily Gastroretentive Gabapentin for Postherpetic Neuralgia: Integrated Efficacy, Time to Onset of Pain Relief and Safety Analyses of Data From Two Phase 3, Multicenter, Randomized, Double-Blind, Placebo-Controlled Studies

Abstract: Context: Treatment options for postherpetic neuralgia (PHN), a complication of herpes zoster, are commonly unsatisfactory and associated with adverse events.Objectives: To evaluate the efficacy, onset of pain relief, and safety of gastroretentive gabapentin (G-GR) in patients with PHN.Methods: In two placebo-controlled studies, 357 patients with PHN were randomized to 1800mg G-GR and 364 patients were randomized to placebo taken with the evening meal. Patients underwent a two week titration, eight weeks of stable dosing, and one week of tapering. Efficacy assessments included change in average daily pain (ADP) score from baseline to Week 10, time to onset of pain relief, the proportion of patients feeling improved using the Patient Global Impression of Change, and the proportion ...

GlaxoSmithKline and XenoPort mutually agree to terminate their collaboration on Horizant

GlaxoSmithKline (GSK) plc announced today that it has reached an agreement with XenoPort, Inc., to terminate their collaboration concerning Horizant&#174; (gabapentin enacarbil) Extended-Release Tablets, for which GSK had commercialisation rights and certain development rights in the United States. (Source: GSK news)

Relative potency of pregabalin, gabapentin, and morphine in a mouse model of visceral pain.

CONCLUSION: In this animal model of visceral pain, all three drugs exhibited parallel dose-response curves. Pregabalin had five times the potency of gabapentin and 1/85(th) the potency of morphine. Similar potency ratios may apply in clinical practice. Despite some limitations of animal studies, this model could be useful for comparing new analgesics in visceral pain treatment. PMID: 23132044 [PubMed - as supplied by publisher] (Source: Canadian Journal of Anaesthesia)

Pregabalin for Alcohol Dependence: A Critical Review of the Literature.

CONCLUSION: Pregabalin, within a dosage of 150-450 mg/day, showed beneficial effects for alcohol relapse prevention and contrasting results for the treatment of the withdrawal syndrome. Its use appears to be safe and well tolerated. PMID: 23132700 [PubMed - as supplied by publisher] (Source: Advances in Therapy)<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>

[Articles] Gabapentin for refractory chronic cough: a randomised, double-blind, placebo-controlled trial

The treatment of refractory chronic cough with gabapentin is both effective and well tolerated. These positive effects suggest that central reflex sensitisation is a relevant mechanism in refractory chronic cough. (Source: LANCET)

[Comment] Gabapentin: a suppressant for refractory chronic cough

This study is also one of the few that have used newly validated measures of cough, including cough-specific quality-of-life measures, cough severity, and cough counts to assess treatment effects. (Source: LANCET)

A cohort description and analysis of the effect of gabapentin on idiopathic cough

Background: Chronic idiopathic cough (known as cough hypersensitivity syndrome) is defined by cough in the absence of an identifiable cause. Gabapentin has been suggested as a treatment but evidence is scarce. The aim of our study was to describe the clinical features of patients with unexplained chronic cough and to investigate the effect of gabapentin (600 mg twice a day for a minimal duration of 4 weeks) in reducing cough symptoms. Methods: A patient cohort analysis was performed. Patients were retrieved using a query in our medical database for the words 'cough' and 'gabapentin' in 2011. Patients without a clear etiology of cough despite having performed a stepwise diagnostic approach, were included. Medical records of these patients were analyzed. A telephonic survey was performed and...

Geriatric Gynecology

Most postmenopausal vaginal bleeding is benign; however, it merits diagnostic evaluation by transvaginal ultrasound or endometrial biopsy after emergency department evaluation. Patients and physicians may treat menopausal symptoms with hormone replacement therapy or other agents, such as venlafaxine or gabapentin. Hormone replacement therapy, when initiated close to the start of menopause and continued at the lowest possible dose for the shortest possible duration, carries less risk than previously believed. Pelvic organ prolapse affects millions of women and may contribute to poor body image and difficulty with urinary, gastrointestinal, and sexual function. Treatment options include Kegel exercises, pessaries, and surgery. (Source: Emergency Medicine Clinics of North America)

Identification of Patients with Painful Diabetic Peripheral Neuropathy Who Have a Favorable Cost Profile with Pregabalin Treatment

ConclusionsThe association of lower total costs among older individuals with pDPN who maintain high adherence to pregabalin therapy relative to key comparators suggests a pharmacoeconomic advantage of pregabalin in this population combined with a need for strategies promoting adherence. (Source: Pain Practice)<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>

A Randomized, Controlled Trial of Gabapentin Enacarbil in Subjects with Neuropathic Pain Associated with Diabetic Peripheral Neuropathy

ConclusionOverall, none of the GEn treatment groups differentiated from placebo. Analyses of the secondary endpoints showed comparable results across treatment groups. However, the majority of the endpoints, including all of the pain endpoints, showed the largest numerical treatment difference was between GEn 3,600 mg and placebo. The active control, PGB (300 mg/day), did not differentiate from placebo. (Source: Pain Practice)

Pregabalin monotherapy for epilepsy.

CONCLUSIONS: Pregabalin seems to have similar tolerability but inferior efficacy in comparison to lamotrigine for newly diagnosed partial seizures. However, considering the limitations in the study design (such as the short-term follow-up and the low initial target dose selection), the results should be interpreted with caution. The available data were too limited to draw any conclusions between pregabalin and gabapentin. The result indicated that the treatment effects were influenced by the study regions. The clinical disadvantage of pregabalin was more prominent in Asia when compared with lamotrigine. We should determine whether pregabalin has ethnic differences in the treatment of epilepsy in the future. This review does not inform any treatment policy for patients with generalized onse...

Antiepileptic Drug Monotherapy Exposure and Suicide‚?źRelated Behavior in Older Veterans

ConclusionExposure to five common AEDs was associated with SRB in older VHA beneficiaries. Given the strong associations between psychiatric comorbidity and SRB, clinicians treating elderly adults should weigh this potential adverse effect into their consideration for treatment of those receiving AEDs. Particular attention should be given to depression and suicidality screening in people prescribed AEDs. (Source: Journal of the American Geriatrics Society)

Pregabalin versus gabapentin in the treatment of neuropathic pruritus in maintenance haemodialysis patients: A prospective, crossover study

Conclusion:‚?? Treatment of neuropathic pain with either pregabalin or gabapentin effectively ameliorates uraemic itch. (Source: Nephrology)

Did the Neurontin lawsuit fuel health spending?

NEW YORK (Reuters Health) - In 2004, Pfizer, the world's largest drug company, agreed to plead guilty and pay more than $430 million to settle charges it had illegally marketed the epilepsy drug Neurontin for unapproved uses. (Source: Reuters: Health)<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>

Restless Legs Syndrome and Periodic Leg Movements of Sleep

Women are more commonly affected than men by restless legs syndrome, and prevalence is highest amongst those of northern European heritage. The motor manifestations include nonvolitional myoclonus (periodic leg movements). Disinhibition of spinal sensorimotor circuits may underlie these primary features and can be affected by peripheral as well as supraspinal networks. Insufficient mobilizable iron stores increase expressivity in some individuals. The sensorimotor features are relieved by dopamine, especially dopamine agonists, gabapentin and its derivatives, and opioids. A diagnosis relies on recognition of key primary and supportive features, and treatments are generally well tolerated, efficacious, and life-changing. (Source: Neurologic Clinics)

A four arm, double blind, randomized and placebo controlled study of pregabalin in the management of post-burn pruritus

Abstract: Post-burn itch is a distressing symptom in burns rehabilitation and its treatment often proves frustrating for the patient and the multidisciplinary burns team. Traditionally, the mainstay of antipruritic therapy for decades has been antihistamines and massage with emollients. With a better understanding of the neurophysiology of itch emerged a new dimension in the treatment of post-burn pruritus. Gabapentin, a centrally modulating anti-epileptic agent and őĪ2őī ligand, proved in clinical trials to be immensely better in the treatment of post-burn pruritus. Pregabalin is a newer structural analog of gabapentin. It has a much better anxiolytic effect and pharmacokinetic profile as compared to gabapentin. The current study was initiated to specifically study the role of pregabalin ...

Once-Daily Gabapentin for Postherpetic NeuralgiaOnce-Daily Gabapentin for Postherpetic Neuralgia

A once-daily, extended-release formulation of gabapentin, recently approved for the management of postherpetic neuralgia, overcomes many of the obstacles associated with the standard dosing regimen. Therapeutic Advances in Chronic Disease (Source: Medscape Today Headlines)

[Neurological manifestations of an osteoid osteoma located on the femoral neck in an 8-year-old boy.]

We report the case of an 8-year-old boy, suffering from nocturnal pain localized on the left groin and presenting as a limp over several months. Examination revealed diminished strength of the left leg, atrophy of the thigh and calf, and a diminished deep tendon reflex. The pain could be intense and the patient had found an analgesic position by pushing on his groin or by flexing his thigh on the pelvis. He could no longer run. He was unsuccessfully treated with carbamazepine and gabapentin. His evaluation included a negative abdominal ultrasound study and a normal spine and cerebral MRI. Electromyography was unremarkable. He finally underwent an MRI of the pelvis that revealed a hyperintense T2 signal of the left femoral neck; CT confirmed the diagnosis of osteoid osteoma. Radiofrequency ...<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>

Gabapentin Improves Menopausal Hot Flashes, InsomniaGabapentin Improves Menopausal Hot Flashes, Insomnia

An investigational nonhormonal drug, extended-release gabapentin, effectively improved sleep and reduced hot flashes in menopausal women. Medscape Medical News (Source: Medscape Today Headlines)

A randomized, controlled, double-blinded clinical trial of gabapentin 300 versus 900 mg versus placebo for anxiety symptoms in breast cancer survivors

Abstract&nbsp;&nbsp;Gabapentin is used for the treatment of hot flashes and neuropathic pain in breast cancer survivors, and is commonly used off-label for the treatment of anxiety. Yet, clinical trial evidence to support the use of gabapentin for anxiety symptoms is lacking. In a randomized, double-blinded controlled trial we compared 300&nbsp;mg gabapentin versus 900&nbsp;mg gabapentin versus placebo. Subjects were 420 breast cancer patients who had completed all chemotherapy cycles. Anxiety traits and current (state) anxiety were measured using the Speilberger Strait-Trait Anxiety Inventory at baseline, 4 and 8&nbsp;weeks. Pain was measured at baseline using a 10-point scale. Analyses included analysis of covariance and ordinary least squares regression. At 4&nbsp;weeks, state anx...

Efficacy of antiepileptic drugs in adults predicts efficacy in children: A systematic review

Conclusions: This systematic review supports the extrapolation of efficacy results in adults to predict a similar adjunctive treatment response in 2- to 18-year-old children with POS. (Source: Neurology)

Thomas M. Greene and Palko S. Goldman of Greene LLP Co-Author Case...

In a partnership between law and medicine characteristic of Greene LLP, attorney Thomas M. Greene and physician Palko S. Goldman have co-authored an article about Pfizer‚??s strategy of promoting...(PRWeb September 27, 2012)Read the full story at http://www.prweb.com/releases/Neurontin/offlabel/prweb9951877.htm (Source: PRWeb: Medical Pharmaceuticals)

Thomas M. Green and Palko S. Goldman of Greene LLP co-author case...

In a partnership between law and medicine characteristic of Greene LLP, attorney Thomas M. Greene and physician Palko S. Goldman have co-authored an article about Pfizer‚??s strategy of promoting...(PRWeb September 27, 2012)Read the full story at http://www.prweb.com/releases/Neurontin/offlabel/prweb9951877.htm (Source: PRWeb: Medical Pharmaceuticals)<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>

Gabapentin may be effective chronic cough therapy

For patients with refractory chronic cough, gabapentin may be an effective treatment to help improve cough-specific quality of life, according to a study published in The Lancet. (Source: Drug Topics - Pharmacy News)

Depomed Files Suit Against The FDA Seeking Grant Of Orphan Drug Exclusivity For Gralise (Gabapentin)

MENLO PARK, Calif., Sept. 25, 2012 /PRNewswire/ -- Depomed, Inc. (Nasdaq:DEPO) today announced that it has filed an action in federal district court for the District of Columbia against the Food and Drug Administration, seeking an order requiring... (Source: Drugs.com - Pharma News)

Treatment of Dyssomnias and Parasomnias in Childhood

Opinion statement&nbsp;&nbsp;Dyssomnias are sleep disorders associated with complaints of insomnia or hypersomnia. The daytime sleepiness of narcolepsy is treated by a combination of planned daytime naps, regular exercise medications such as modafinil, or salts of methylphenidate, or amphetamine. Cataplexy that accompanies narcolepsy is treated with anticholinergic agents, selective serotonin reuptake inhibitors, or sodium oxybate. Children with neurodevelopmental disabilities such as autism have sleep initiation and maintenance difficulties on a multifactorial basis, with favorable response to melatonin in some patients. Childhood onset restless legs syndrome is often familial, associated with systemic iron deficiency, and responsive to iron supplementation and gabapentin. Parasomni...

A Single Preoperative Dose of Gabapentin Does Not Improve Postcesarean Delivery Pain Management: A Randomized, Double-Blind, Placebo-Controlled Dose-Finding Trial.

CONCLUSION:Given the wide confidence intervals of the differences in mean pain scores, the current study did not allow us to determine whether a single preoperative dose of gabapentin (300 mg and 600 mg) improved postcesarean analgesia compared to placebo in the context of a multimodal analgesic regimen. A larger study is required. PMID: 23011560 [PubMed - as supplied by publisher] (Source: Anesthesia and Analgesia)<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>

Arizona sues McKesson over inflated drug prices

The state of Arizona has filed a lawsuit against McKesson Corp., alleging the nation‚??s largest drug wholesaler has artificially inflated the prices of more than 400 brand-name prescription drugs. Among the drugs that are alleged to have been marked-up inappropriately are: Allegra, Azmacort, Celebrex, Coumadin, Flonase, Lipitor, Neurontin, Nexium, Prevacid and Valium. The complaint was filed in Maricopa County Superior Court, alleging that the scheme began in 2000 to mark up the average wholesale‚?¶ (Source: bizjournals.com Health Care:Hospitals headlines)

Gabapentin the `Holy Grail' for chronic cough suffers?

(Source: PharmacoEconomics and Outcomes News)

Patterns of nerve injury and neuropathic pain in ischemic neuropathy after ligation‚?źreperfusion of femoral artery in mice

Ischemia is an important etiology of painful neuropathies. We generated a mouse system of ischemic neuropathy by ligation‚?źreperfusion of the femoral artery to mimic neuropathic pain and nerve injury patterns observed clinically. Mice exhibited spontaneous neuropathic pain behaviors, which were most obvious after ischemia for 5 h. Mechanical and cold allodynia developed by post‚?źoperative day (POD) 7 and persisted through the experimental period up to POD 56. Neuropathic pain behaviors were alleviated with intraperitoneal gabapentin (50 and 100 mg/kg) in a dose‚?źdependent manner. Large‚?źfiber deficit assessed with nerve conduction studies was demonstrated by reduced amplitudes of the compound muscle action potential (CMAP) on POD 7 (48.4% of the control side, p &lt; 0.001). Small‚?źfib...

NEURONTIN (Gabapentin) Capsule NEURONTIN (Gabapentin) Tablet, Film Coated NEURONTIN (Gabapentin) Solution [Parke-Davis Div Of Pfizer Inc]

Updated Date: Sep 11, 2012 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

Gabapentin in the treatment of persistent hiccups in advanced malignancy

Mahesh MenonIndian Journal of Palliative Care 2012 18(2):138-140Hiccups are a distressing symptom in advanced malignancies in the setting of palliative care. A case of persistent hiccups treated with oral Gabapentin is presented to highlight the clinical and ethical dilemmas in patients with advanced malignancy. A 70-year-old male with non-small cell cancer of the lung with widespread metastases presented with persistent hiccups. The patient and family sought only symptom relief from home, without hospitalization or further investigations. The hiccups were dramatically relieved by oral Gabapentin, highlighting the recent reports that mention this molecule as being useful for hiccups. Gabapentin is a simple tool that may be utilized by palliative care physicians to relieve hiccups in advanc...<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>

The Efficacy of Gabapentin versus Stabilization Splint in Management of Sleep Bruxism

Conclusions: Gabapentin could be an effective treatment modality in SBs, especially in those with poor sleep quality. (Source: Journal of Prosthodontics)

Vital Signs: Regimens: Anticonvulsant May Relieve Chronic Cough

A study of 62 patients with chronic cough in Australia found that those given gabapentin, an anticonvulsant, saw a decline in severity and frequency of coughing. (Source: NYT Health)

Dose related efficacy of gabapentin in acute herpetic neuralgia among geriatric patients

Conclusion: The results of this study show that gabapentin is effective in acute herpetic neuralgia in different doses with 600 mg/day being the more appropriate dose in terms of safety and efficacy. (Source: Indian Journal of Dermatology)

Nonfatal tramadol overdose may cause false-positive phencyclidine on Emit-II assay

This report describes 2 patients with positive phencyclidine (PCP) screens using the Emit II Plus Drugs-of-Abuse Test (Siemens Healthcare Diagnostics, Inc, Tarrytown, NY) after tramadol ingestion. Our first case was a 43-year-old woman with a history of bipolar disorder who presented to the emergency department(ED) for medical clearance after ingesting an unknown amount of tramadol. Her urine drugs-of-abuse screen was positive for PCP. A comprehensive gas chromatography/mass spectrometry qualitative urine drug screen demonstrated valproic acid metabolites, nicotine, gabapentin, benztropine, and a large peak of tramadol. Our second case was a 3-year-old boy with a medical history of previous ingestions presented to the ED for altered mental status and suspected ingestion. His urine drugs-of...

European guidelines on management of restless legs syndrome: report of a joint task force by the European Federation of Neurological Societies, the European Neurological Society and the European Sleep Research Society

BackgroundSince the publication of the first European Federation of Neurological Societies (EFNS) guidelines in 2005 on the management of restless legs syndrome (RLS; also known as Willis‚?źEkbom disease), there have been major therapeutic advances in the field. Furthermore, the management of RLS is now a part of routine neurological practice in Europe. New drugs have also become available, and further randomized controlled trials have been undertaken. These guidelines were undertaken by the EFNS in collaboration with the European Neurological Society (ENS) and the European Sleep Research Society (ESRS). ObjectivesTo provide an evidence‚?źbased update of new treatments published since 2005 for the management of the RLS. MethodsFirst, we determined what the objectives of management of prima...<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>

The Intestinal Absorption Mechanism of Gabapentin Makes It Appropriate for Gastroretentive Delivery.

Authors: Chen C, Cowles VE, Sweeney M Abstract Gabapentin is approved for the treatment of postherpetic neuralgia (PHN) and epilepsy. The pharmacokinetic (PK) properties of gabapentin, including absorption, distribution, metabolism, and excretion (ADME), were investigated during the development of Neurontin¬ģ, an immediate-release (IR) formulation of gabapentin that is orally administered three-times daily. Recently, a gastroretentive (GR) once-daily formulation of gabapentin (Gralise¬ģ) has been developed and marketed for the treatment of PHN. This review focuses on the ADME properties of gabapentin and illustrates how GR delivery enhances its absorption compared with IR formulations and allows once-daily dosing with the evening meal for the treatment of PHN. It includes the foll...

Anti-Epileptic Seen to Quiet Chronic Cough (CME/CE)

(MedPage Today) -- The seizure and pain drug gabapentin may ease a persistent cough unresponsive to other treatments, researchers found. (Source: MedPage Today Neurology)

Gabapentin Improves Chronic Cough Gabapentin Improves Chronic Cough

In patients with chronic cough, gabapentin led to improved cough symptoms compared with placebo. Medscape Medical News (Source: Medscape Today Headlines)

Collagen antibody‚?źinduced arthritis evokes persistent pain with spinal glial involvement and transient prostaglandin dependency

Conclusions.CAIA represents a multifaceted model for studies exploring mechanisms of pain induced by inflammation in the articular joint. Our findings of a time‚?źdependent prostaglandin and spinal glial contribution to antibody‚?źinduced pain highlight the importance of using appropriate disease models to assess joint‚?źrelated pain. ¬© 2012 American College of Rheumatology. (Source: Arthritis and Rheumatism)

Epilepsy Drug Gabapentin Calms Chronic Cough

Title: Epilepsy Drug Gabapentin Calms Chronic CoughCategory: Health NewsCreated: 8/28/2012 11:01:00 AMLast Editorial Review: 8/28/2012 12:00:00 AM (Source: MedicineNet Chronic Pain General)<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>

GRALISE (Gabapentin) Tablet, Film Coated GRALISE STARTER PACK (Gabapentin) Kit [Depomed, Inc.]

Updated Date: Aug 28, 2012 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

Small study shows gabapentin may be efficacious for refractory chronic cough

Source: Lancet Area: News The Lancet has featured a study evaluating the efficacy of gabapentin in patients with refractory chronic cough. &#160; The double-blind, placebo-controlled trial involved 62 patients with refractory chronic cough (&#62;8 weeks' duration) without active respiratory disease or infection who were randomised to receive gabapentin (maximum tolerable daily dose of 1800 mg, n=32) or matching placebo (n=30) for 10 weeks. The primary endpoint was change in cough-specific quality of life (Leicester cough questionnaire [LCQ] score) from baseline to 8 weeks of treatment. The researchers reported that statistically significantly more participants in the gabapentin group still in the study at week 8 had a clinical improvement in LCQ score of greater than 1.3 (the smallest...

Epilepsy Drug Gabapentin Calms Chronic Cough

A drug used to treat epilepsy and chronic pain after shingles also appears to be effective for another persistent condition: chronic cough. (Source: WebMD Health)

Dose Response of Gabapentin Enacarbil versus Placebo in Subjects with Moderate-to-Severe Primary Restless Legs Syndrome: An Integrated Analysis of Three 12-Week Studies

(Source: CNS Drugs)<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>

Steady-State Pharmacokinetics of Gabapentin after Administration of a Novel Gastroretentive Extended-Release Formulation in Postmenopausal Women with Vasomotor Symptoms

(Source: Clinical Drug Investigation)

Kinetic Considerations on the Development of Binding Assays in Single-Addition Mode: Application to the Search for {alpha}2{delta}1 Modulators

This article shows the development of a single-addition, displacement-based binding assay intended to identify modulators that act by binding to the gabapentin site of the ion channel regulatory protein &alpha;21. After studying the kinetics of gabapentin binding and the influence they might have on the assay sensitivity, the best conditions were identified, and the sensitivity was compared with that of the more classical two-additions competition-based assay. Although the present study focuses on &alpha;21 and its interaction with gabapentin, the rationale and the methodology followed are of broad purpose and can be applied to virtually every binding assay. (Source: Journal of Biomolecular Screening)

Implementation of a publication strategy in the context of reporting biases. A case study based on new documents from Neurontin&#174; litigation

Conclusions: Taken together, the extracts we present from internal company documents illustrate implementation of a strategy at odds with unbiased study conduct and dissemination. Pfizer and Parke-Davis's "publication strategy" had the potential to distort the scientific literature, and thus misinform healthcare decision-makers. (Source: BioMed Central)

Implementation of a publication strategy in the context of reporting biases. A case study based on new documents from Neurontin¬ģ litigation

Conclusions: Taken together, the extracts we present from internal company documents illustrate implementation of a strategy at odds with unbiased study conduct and dissemination. Pfizer and Parke-Davis's "publication strategy" had the potential to distort the scientific literature, and thus misinform healthcare decision-makers. (Source: Trials)

Effect of second-generation antiepileptic drugs on diplopia: A meta-analysis of placebo-controlled studies

In this study, we compared several second-generation AEDs to find out whether they would contribute to the risk of diplopia and their effect-causing dose. A meta-analysis was performed on 19 studies in agreement with our inclusion criteria. The results showed that eight commonly used second-generation AEDs (gabapentin, levetiracetam, oxcarbazepine, lamotrigine, pregabalin, topiramate, vigabatrin and zonisamide) could cause diplopia. The reported odds ratios (ORs) ranged from 1.406 to 7.996. Ranking risks from the highest to the lowest ORs of the eight AEDs of any dose resulted in the following order: use of oxcarbazepine (7.996), levetiracetam (7.472), lamotrigine (5.258), vigabatrin (3.562), pregabalin (3.048), topiramate (2.660), gabapentin (1.966), zonisamide (1.406). Taking into ...<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>

Treatment of essential tremor: a systematic review of evidence and recommendations from the Italian Movement Disorders Association

Abstract&nbsp;&nbsp;Essential tremor (ET) is one of the most common movement disorders of adults, characterized by postural and kinetic tremor. It often causes embarrassment and more rarely serious disability, requiring treatment. To assess the current state of knowledge on ET therapy and produce recommendations based on the analysis of evidence the authors reviewed the literature regarding pharmacologic and surgical therapies, providing a quality assessment of the studies and the strength of recommendations for each treatment. A committee of experts selected clinical-based questions to guide the search. A systematic literature review was performed to identify all the studies conducted on patients with ET published until September 2010. Articles were classified according to GRADE evi...

Combination pharmacotherapy for the treatment of neuropathic pain in adults.

CONCLUSIONS: Multiple, good-quality studies demonstrate superior efficacy of two-drug combinations. However, the number of available studies for any one specific combination, as well as other study factors (e.g. limited trial size and duration), preclude the recommendation of any one specific drug combination for neuropathic pain. Demonstration of combination benefits by several studies together with reports of widespread clinical polypharmacy for neuropathic pain surely provide a rationale for additional future rigorous evaluations. In order to properly identify specific drug combinations which provide superior efficacy and/or safety, we recommend that future neuropathic pain studies of two-drug combinations include comparisons with placebo and both single-agent components. Given the appa...

A Lack of Safety Data on Kids Drugs Puts Pediatricians in a Bind

It is a conundrum that has frustrated pediatricians for decades: children get sick and need drugs, yet few medications have been approved for their use. A recent study and a government report published in February concluded that, most of the time, doctors are forced to prescribe drugs to young patients without adequate data, putting kids at risk for overdoses, side effects and long-term health problems. In late June Congress was poised to strengthen existing laws that encourage pharmaceutical companies to test medicines in kids, but that won&apos;t solve the safety problems associated with pediatric drugs.Drugmakers resist testing their products in children because doing so is risky, expensive and difficult--and it is rarely worthwhile from a business perspective because children make up a...

Complex regional pain syndrome following protracted labour*

Summary Obstetric nerve palsies are common and long‚?źterm sequelae are fortunately rare. The development of a complex regional pain syndrome is an unusual and less reported complication of labour‚?źrelated neuropathy. A 28‚?źyear‚?źold primigravida who experienced prolonged labour and instrumental delivery under spinal anaesthesia complained of persisting weakness and numbness postpartum, affecting the left lower limb. Urgent magnetic resonance imaging demonstrated no abnormality and a common peroneal nerve injury was later confirmed by nerve conduction studies. Unfortunately, the neuropathy did not resolve as expected and oedema, burning paraesthesia and allodynia affecting the left foot developed within two‚??weeks. She was treated with gabapentin, ibuprofen, topical capsaicin and regul...

The Impact of Gabapentin Administration on Brain GABA and Glutamate Concentrations: A 7T 1H-MRS Study

Authors: Kejia Cai, Ravi PR Nanga, Lisa Lamprou, Claudia Schinstine, Mark Elliott, Hari Hariharan, Ravinder Reddy & C Neill Epperson Keywords: 1H-MRS; GABA; gabapentin; glutamate; imaging; clinical or preclinical; magnetic resonance spectroscopy; psychopharmacology; visual cortex (Source: Neuropsychopharmacology)<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>

Treatment with Gabapentin Associated with Resolution of Apnea in Two Infants with Neurologic Impairment

Journal of Palliative Medicine , Vol. 0, No. 0. (Source: Journal of Palliative Medicine)

New Drug Application submitted to FDA for extended release formulation of gabapentin (Serada) for the treatment of menopausal hot flushes.

Source: BioSpace Area: News Depomed, Inc. has announced that it has submitted a New Drug Application (NDA) for an extended release formulation of gabapentin (Serada) to the FDA for the treatment of menopausal hot flushes. The application includes data from three phase III studies: Breeze 3 completed in 2011, Breeze 1 and Breeze 2 completed in 2009. Additional data from the Breeze clinical program will be presented at the North American Menopause Society Annual Meeting in the fourth quarter of 2012. (Source: NeLM - News)

Substance misuse of gabapentin.

Authors: Smith BH, Higgins C, Baldacchino A, Kidd B, Bannister J PMID: 22867659 [PubMed - in process] (Source: The British Journal of General Practice)

Pregabalin versus Gabapentin in the Treatment of Neuropathic Pruritus in Maintenance Hemodialysis Patients: a Prospective Crossover Study

Conclusion:‚?? Treatment of neuropathic pain with either pregabalin or gabapentin effectively ameliorates uremic itch.¬© 2012 The Authors. Nephrology ¬© 2012 Asian Pacific Society of Nephrology (Source: Nephrology)

The Treatment of Restless Legs Syndrome and Periodic Limb Movement Disorder in Adults‚??An Update for 2012: Practice Parameters with an Evidence-Based Systematic Review and Meta-Analyses

A systematic literature review and meta-analyses (where appropriate) were performed to update the previous AASM practice parameters on the treatments, both dopaminergic and other, of RLS and PLMD. A considerable amount of literature has been published since these previous reviews were performed, necessitating an update of the corresponding practice parameters. Therapies with a STANDARD level of recommendation include pramipexole and ropinirole. Therapies with a GUIDELINE level of recommendation include levodopa with dopa decarboxylase inhibitor, opioids, gabapentin enacarbil, and cabergoline (which has additional caveats for use). Therapies with an OPTION level of recommendation include carbamazepine, gabapentin, pregabalin, clonidine, and for patients with low ferritin levels, iron supple...<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>

Exposure to predator odor and resulting anxiety enhances the expression of the őĪ2őī subunit of voltage‚?źsensitive calcium channels in the amygdala

AbstractThe őĪ2őī subunit of voltage‚?źsensitive calciumchannels (VSCCs) is the molecular target of pregabalinand gabapentin, twodrugsmarked forthetreatmentof focal epilepsy,neuropathic pain, and anxiety disorders. ExpressionoftheőĪ2őīsubunitisup‚?źregulatedinthedorsalhornsof the spinal cordinmodels of neuropathic pain, suggestingthatplastic changesin theőĪ2őīsubunit are associated with pathological states. Here, we examined the expression of the őĪ2őī‚?ź1 subunitin the amygdala, hippocampus and frontal cortexinthetrimethyltiazoline (TMT)mousemodel ofinnate anxiety. TMTisa volatilemoleculepresentinthefecesoftherodentpredator,red fox. Micethat showahighdefensivebehaviorduring TMT exposuredeveloped anxiety‚?źlike behaviorin the following 72hours, as shownby thelight‚?źdark test. Anxiety was ...

Effect of catalytic alkali metal bromide on Hofmann-type rearrangement of imides

Chem. Commun., 2012, 48,8574-8576DOI: 10.1039/C2CC33914E, CommunicationKatsuhiko Moriyama, Kazuma Ishida, Hideo TogoThe Hofmann-type rearrangement of aromatic and aliphatic imides using KBr as the catalyst proceeded to provide aromatic and aliphatic amino acid derivatives. We have also developed a new synthetic route to gabapentin with this method.The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Chem. Commun. latest articles)

Gabapentin's minimal action on markers of rat brain arachidonic acid metabolism agrees with its inefficacy against bipolar disorder

Abstract: In rats, FDA-approved mood stabilizers used for treating bipolar disorder (BD) selectively downregulate brain markers of the arachidonic acid (AA) cascade, which are upregulated in postmortem BD brain. Phase III clinical trials show that the anticonvulsant gabapentin (GBP) is ineffective in treating BD. We hypothesized that GBP would not alter the rat brain AA cascade. Chronic GBP (10mg/kg body weight, injected i.p. for 30 days) compared to saline vehicle did not significantly alter brain expression or activity of AA-selective cytosolic phospholipase A2 (cPLA2) IVA or secretory (s)PLA2 IIA, activity of cyclooxygenase-2, or prostaglandin E2 or thromboxane B2 concentrations. Plasma esterified and unesterified AA concentration was unaffected. These results, taken with evidence of an...

The management of menopausal symptoms in breast cancer survivors: A case-based approach

Conclusion: The management of vasomotor symptoms and impaired sexual functioning in breast cancer survivors should focus on lifestyle and, if necessary, non-hormonal pharmacological interventions. (Source: Maturitas)

Pustular Eruption in the ICU

Sometimes, appropriate treatment can introduce new problems for patients who are already seriously ill. This was true for a 62-year-old man with a history of chronic obstructive pulmonary disease, atrial fibrillation, and peripheral vascular disease. He was admitted to the hospital for a gangrenous right foot, and his medications on admission included aspirin, gabapentin, paroxetine, ranitidine, and tramadol. On the first day of admission, he was febrile to 101.5¬į F (38.6¬į C) and was started on piperacillin-tazobactam and vancomycin. These antibiotics were administered for 2 weeks and then discontinued the day before a below-the-knee amputation. (Source: The American Journal of Medicine)<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>

Analysis of Selected Anticonvulsants by High Performance Liquid Chromatography-Tandem Mass Spectrometry

A method for the analysis of the basic antiepileptic compounds felbamate, lamotrigine, carbamazepine, carbamazepine-10,11-epoxide, gabapentin, pregabalin, levetiracetam, and oxcarbazepine monohydroxy derivative (oxcarb MHD) in human plasma is described. This protocol incorporates a simplified sample preparation step followed by quantitative high performance chromatography-tandem mass spectrometry detection of commonly prescribed and monitored anticonvulsant drugs. Since polytherapy is common in epilepsy patients, use of a multiconstituent assay can improve laboratory efficiency and reduce required analytical time. (Source: Springer protocols feed by Pharmacology/Toxicology)

The amygdala to periaqueductal gray pathway: Plastic changes induced by audiogenic kindling and reversal by gabapentin.

We examined AGS kindling-induced changes in vlPAG extracellular action potentials evoked by electrical stimuli in CeA in awake, behaving GEPR-9s, using chronically-implanted stimulation electrodes in CeA and microwire recording electrodes in vlPAG. The effect of gabapentin, an anticonvulsant drug that is also effective in pain and anxiety disorders, on the CeA to vlPAG pathway in AGS-kindled GEPR-9s was also evaluated. Electrical stimulation in CeA evoked consistent, short latency and intensity-dependent vlPAG neuronal firing increases. However, in AGS-kindled GEPR-9s these responses showed a precipitous firing increase with increasing stimulus intensity, as compared to non-kindled GEPR-9s. Gabapentin (50mg/kg, i.p.) significantly reduced vlPAG neuronal responses to CeA stimulation to pre-...

Inhibition of sEH blocks neuropathic pain [Pharmacology]

The nerve damage occurring as a consequence of glucose toxicity in diabetes leads to neuropathic pain, among other problems. This pain dramatically reduces the quality of life in afflicted patients. The progressive damage to the peripheral nervous system is irreversible although strict control of hyperglycemia may prevent further damage. Current treatments include tricyclic antidepressants, anticonvulsants, and opioids, depending on the severity of the pain state. However, available therapeutics have drawbacks, arguing for the need to better understand the pathophysiology of neuropathic pain and develop novel treatments. Here we demonstrate that stabilization of a class of bioactive lipids, epoxygenated fatty acids (EpFAs), greatly reduces allodynia in rats caused by streptozocin-induced t...

Orofacial pain due to trigeminal autonomic cephalgia with features of short-lasting neuralgiform headache attacks with conjunctival injection and tearing: a case report

We present a case of a 64-year-old woman with a presumptive diagnosis of short-lasting unilateral neuralgiform headache attacks with conjunctival injection and tearing (SUNCT) syndrome with telangiectasia. Dental procedures were not successful in alleviating the condition. Results: The patient's symptoms of short unilateral severe pain episodes abated after geographic relocation, although orofacial pain continued. Sphenoid sinus surgery further decreased the patient's chronic pain complaints. The patient's current pain condition is controlled with gabapentin therapy. Clinical Implications: Diagnostic, etiologic, and therapeutic issues related to SUNCT syndrome are discussed. This case represents the first case report of trigeminal autonomic cephalgia with SUNCT syndrome‚??like features...

Effects of a single 1200-mg preoperative dose of gabapentin on anxiety and memory.

CONCLUSION: Gabapentin premedication, 1200mg, provided preoperative anxiolysis without causing sedation or impairing preoperative memory. PMID: 22770920 [PubMed - as supplied by publisher] (Source: Annales Francaises d'Anesthesie et de Reanimation)<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>

Non-surgical therapy for bilateral glossopharyngeal neuralgia caused by Eagle‚??s syndrome, diagnosed by three-dimensional computed tomography: a case report

We report a 65-year-old man who presented with bilateral glossopharyngeal neuralgia. We performed three-dimensional computed tomography which revealed that the right styloid process was 35.1&nbsp;mm and the left process was 29.6&nbsp;mm, leading to diagnosis of an elongated styloid process, i.e. Eagle‚??s syndrome. Because the patient refused surgical treatment, conservative therapy was selected. Oral gabapentin, stellate ganglion block, and 8&nbsp;% lidocaine spray on the tonsillar branches of the glossopharyngeal nerve resulted in complete resolution of the paroxysms of pain in approximately 3&nbsp;weeks. Content Type Journal ArticleCategory Clinical ReportPages 1-4DOI 10.1007/s00540-012-1437-zAuthors Masanori Kawasaki, Department of Anesthesiology, Kanazawa Medical Universit...

Early Pain Reduction Can Predict Treatment Response: Results of Integrated Efficacy Analyses of a Once‚?źDaily Gastroretentive Formulation of Gabapentin in Patients with Postherpetic Neuralgia

Conclusions.‚?? Early response was a reliable predictor of final response. This approach holds promise for aiding clinicians in decision making regarding the need for alternative or supplemental treatment during G‚?źGR therapy for PHN. (Source: Pain Medicine)

Gabapentin decreases epileptiform discharges in a chronic model of neocortical trauma.

Authors: Li H, Graber KD, Jin S, McDonald W, Barres BA, Prince DA Abstract Gabapentin (GBP) is an anticonvulsant that acts at the ‚?°2‚?°1 submit of the L-type calcium channel. It is recently reported that GBP is a potent inhibitor of thrombospondin (TSP)-induced excitatory synapse formation in vitro and in vivo. Here we studied effects of chronic GBP administration on epileptogenesis in the partial cortical isolation ("undercut") model of posttraumatic epilepsy, in which abnormal axonal sprouting and aberrant synaptogenesis contribute to occurrence of epileptiform discharges. Results showed that 1) the incidence of evoked epileptiform discharges in undercut cortical slices studied 1day or ~2weeks after the last GBP dose, was significantly reduced by GBP treatments, beginning on th...

[Catheter-related bladder discomfort in post-anaesthesia care unit].

Authors: Tauzin-Fin P, Stecken L, Sztark F Abstract Catheter-related bladder discomfort (CRBD) is an unrecognized clinical event. Symptoms of CRBD secondary to an indwelling urinary catheter mimic those of an overactive bladder, i.e. urinary frequency and urgency with or without urge incontinence. Stimulation of muscarinic receptors located in the bladder wall by the catheter is the triggering factor. Postoperative pain may be increased by the CRBD. Antimuscarinic drugs, as oxybutynin, are today the main treatment. Further studies are warranted to confirm efficacy of ketamine, tramadol and gabapentin in this situation. PMID: 22749555 [PubMed - in process] (Source: Annales Francaises d'Anesthesie et de Reanimation)

Assessment of the effects of adjunctive gabapentin on postoperative pain after intervertebral disc surgery in dogs

Conclusions and clinical relevance‚?? 10‚??mg‚??kg‚??1 GBP orally twice a day did not result in a detectable reduction in pain behaviour compared to background opioid analgesia alone, although a trend to lower pain levels (p‚??&lt;‚??0.1) was present. Further studies are needed to determine if this is related to effective background analgesia or an ineffective dose of GBP. (Source: Veterinary Anaesthesia and Analgesia)<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>

Pregabalin and gabapentin for post-photorefractive keratectomy pain: a randomized controlled trial.

Conclusions. Pregabalin and gabapentin seem to be helpful in alleviating post-PRK pain when combined with other measures. Depending on availability, either compound can be used as an adjuvant for pain control in this setting. PMID: 22577038 [PubMed - in process] (Source: European Journal of Ophthalmology)

Temperature-dependent enhancement of the antinociceptive effects of opioids in combination with gabapentin in mice.

Authors: Neelakantan H, Walker EA Abstract Prescription opioids and anticonvulsants such as gabapentin are often used as combination therapeutics for chronic as well as acute post-operative pain conditions although the effectiveness of such combinations may be dependent on the intensity of the pain state. To test the capacity of gabapentin to enhance opioid effectiveness in the presence of different thermal stimulus intensities, morphine, oxycodone and gabapentin were examined alone and in combination for antinociception in Swiss-Webster male mice using a hot-plate set to one of three temperature intensities (48.5√?¬?√?¬įC, 50.5√?¬?√?¬įC, 52.5√?¬?√?¬įC). Morphine and oxycodone produced significant dose- and stimulus intensity-dependent antinociception whereas gabapentin produced on...

Use of Gabapentin and Pregabalin for Hand Surgery Patients

The widespread interest of 2 anticonvulsants, gabapentin (Neurontin; Pfizer, Inc., New York, NY) and pregabalin (Lyrica; Pfizer, Inc.), is reflected by their clinical versatility and over 1500 related publications in just the past 5 years. Gabapentin is a synthetic analog of gamma-aminobutyric acid, initially approved by the US Food and Drug Administration (FDA) in 1994 for the adjunctive treatment of seizure disorders. One decade later, pharmacologically similar pregabalin received FDA approval for the treatment of partial onset seizures, diabetic neuropathy, and postherpetic neuralgia. In 2007, pregabalin became the first FDA-approved medication indicated specifically for the treatment of fibromyalgia. Prescriptions intended for off-label uses, however, constitute a vast majority of tota...

Treating anxiety by discontinuing antidepressants: A case series

This study is limited by the outcome measure used, which assesses anxiety only indirectly in the context of global improvement. However, in view of the broad implications of the findings, these preliminary observations warrant further consideration. Some patients with anxiety may be treatable not by adding medications, but rather by tapering off existing ones. (Source: Medical Hypotheses)

Stress, Depression and Alpha2delta Ligands

This study is good news. Results demonstrate the new pharmacological activity of őĪ2őī ligands maypotentially explain their efficacy as add-on therapy in MDD, as well as on depressive symptomsin PTSD and GAD. This knowledge will help the discovery of refined therapies for these debilating disorders. (Source: Neuromics)<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>

Slowly enlarging gingival mass in a 50-year-old man

A 50-year-old man presented to the Dental Clinic of the Washington, DC, Department of Veterans Affairs Medical Center with a triangle-shaped, dark red, lobular, soft gingival mass protruding from the embrasure of the maxillary central incisors (). There was no ulceration or erosion of the surface. The patient reported that the growth had been present for about 2 months and was slowly enlarging. His past medical history was remarkable for an excisional biopsy of a small ‚??fibroma,‚?Ě which consisted of mature collagen bands and bundles with a few foci of inflammatory cells, in the lower labial mucosa 14 months previously. He also had undergone a total hip replacement 3 months previously. His medications included flunisolide, gabapentin, hydrochlorothiazide, and vardenalil. Routine blood te...

Multimodal Approach for the Management of Hunan Hand Syndrome: A Case Report

We report a case of Hunan hand syndrome, managed successfully by using a multimodal approach comprised of a continuous stellate ganglion block, gabapentin, local ice water, and fluocinonide application. (Source: Pain Practice)

[Anaesthesia of epileptic patient.]

Authors: Engrand N Abstract Although surgery of brain tumors and epilepsy are restricted to few specialized centers, anaesthesia for a patient with epilepsy is commonly encountered. Surgical treatments of epilepsy are currently soaring due to the lack of significant progress about effectiveness of antiepileptic drugs (AEDs). Theoretical principles for the anaesthesiologist are quite complex, involving interactions between physiological and pharmacological anaesthesia and AEDs, such as enzyme induction with the first generation molecules mainly (phenytoin, carbamazepin, phenobarbital). The latest generation AEDs (levetiracetam, lamotrigine, gabapentin, oxcarbazepin, vigabatrin, lacosamide...) are better tolerated and induce fewer drug interactions. Practically, the risk of severe pe...

Horizant (gabapentin) gets FDA nod for postherpetic neuralgia

(Source: Modern Medicine)

RLS Drug Gets New Indication

WASHINGTON (MedPage Today) -- The FDA has approved the restless legs syndrome drug gabapentin enacarbil (Horizant) to treat postherpetic neuralgia. (Source: MedPage Today Geriatrics)<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>

Postherpetic Neuralgia - GlaxoSmithKline And XenoPort Receive FDA Approval For Horizant

FDA approval is always welcome news, especially to patients needing treatment and stockholders waiting patiently for a return. GlaxoSmithKline and Xenoport announced today that the FDA has approved its Horizant new drug for postherpetic neuralgia (PHN) in adults. The drug, known pharmaceutically as gabapentin enacarbil, is given as extended release tablets for the painf that occurs as a complication of shingles and affects the nerve fibres and skin. Shingles could be termed as the adult version of the childhood disease chicken pox... (Source: Health News from Medical News Today)

FDA Approves Gabapentin Enacarbil for Postherpetic NeuralgiaFDA Approves Gabapentin Enacarbil for Postherpetic Neuralgia

Already approved for restless legs syndrome, gabapentin enacarbil extended-release tablets are now approved to manage postherpetic neuralgia in adults. FDA Approvals (Source: Medscape Today Headlines)

GSK and XenoPort Receive FDA Approval for Horizant(R) for Postherpetic Neuralgia

LONDON & RESEARCH TRIANGLE PARK, N.C. & SANTA CLARA, Calif.--(Healthcare Sales & Marketing Network)--GlaxoSmithKline plc (GSK) and XenoPort, Inc. (XNPT) announced today that the United States (US) Food and Drug Administration (FDA) has approved Horizant&re... Biopharmaceuticals, FDAXenoPort, GlaxoSmithKline, Horizant, gabapentin, postherpetic neuralgia (Source: HSMN NewsFeed)

GSK and XenoPort receive FDA approval for Horizant¬ģ for postherpetic neuralgia

GlaxoSmithKline plc (GSK) and XenoPort, Inc. (Nasdaq: XNPT) announced today that the United States (US) Food and Drug Administration (FDA) has approved Horizant¬ģ (gabapentin enacarbil) Extended-Release Tablets for the management of postherpetic neuralgia (PHN) in adults. (Source: GSK news)

Study of emotional and cognitive impairments in mononeuropathic rats: Effect of duloxetine and gabapentin

Summary: Cognitive rather than emotional impairments seem to be present in neuropathic rats. These changes can be reversed by duloxetine and gabapentin.Abstract: Chronic pain is a multidimensional experience that not only includes changes in nociception, but also impairments in emotion and cognitive functions. These last 2 components are not often taken into account in preclinical research. We investigated emotional and cognitive impairments in a model of neuropathic pain in rats induced by chronic constriction injury (CCI) of the sciatic nerve. Nociceptive response, anxiety and depressive-like behaviours as well as cognitive capacities were analysed, and the effect of per os administration of duloxetine and gabapentin was studied. In the electronic von Frey test, CCI rats exhibited mechan...<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>

Seizure Treatment in Transplant Patients

Opinion statement&nbsp;&nbsp;Solid organ transplantation is frequently complicated by a spectrum of seizure types, including single partial-onset or generalized tonic-clonic seizures, acute repetitive seizures or status epilepticus, and sometimes the evolution of symptomatic epilepsy. There is currently no specific evidence involving the transplant patient population to guide the selection, administration, or duration of antiepileptic drug (AED) therapy, so familiarity with clinical AED pharmacology and application of sound judgment are necessary for successful patient outcomes. An initial detailed search for symptomatic seizure etiologies, including metabolic, infectious, cerebrovascular, and calcineurin inhibitor treatment-related neurotoxic complications such as posterior reversibl...

The pharmacological treatment of acquired nystagmus.

Authors: Mehta AR, Kennard C Abstract We review the latest literature on the neuropharmacological treatments for acquired nystagmus. Nystagmus may have a significantly impact on health, yet there is little scientific evidence on which to make firm recommendations for treatment. Acquired pendular nystagmus may respond to gabapentin or memantine; downbeat and upbeat nystagmus to aminopyridines; and periodic alternating nystagmus to baclofen. To improve treatment we need multi-centre, randomised controlled trials using standardised techniques in reporting objective outcomes, with good follow-up duration and careful reporting of side effects. PMID: 22661344 [PubMed - in process] (Source: Practical Neurology)

The 2012 AHS/AAN Guidelines for Prevention of Episodic Migraine: A Summary and Comparison With Other Recent Clinical Practice Guidelines.

Conclusion.- The AHS/AAN and Canadian guidelines are recommended for use on the basis of the AGREE-II quality assessment. Recommendations for the future development of clinical practice guidelines in migraine are provided. In particular, efforts should be made to ensure that guidelines are regularly updated and that guideline developers strive to locate and incorporate unpublished clinical trial evidence. PMID: 22671714 [PubMed - in process] (Source: Headache)

Newer anticonvulsants: Lamotrigine, topiramate and gabapentin

CONCLUSIONS The information available suggests an increased risk of oral clefts in infants exposed to topiramate, and perhaps lamotrigine, early in pregnancy, and of growth retardation for topiramate‚?źexposed infants. Larger sample sizes are needed to clarify the questions that have been raised. Birth Defects Research (Part A) 2012. ¬© 2012 Wiley Periodicals, Inc. (Source: Birth Defects Research Part A: Clinical and Molecular Teratology)

Four treatment strategies for complex regional pain syndrome type 1.

Authors: Lee SK, Yang DS, Lee JW, Choy WS Abstract Complex regional pain syndrome (CRPS) poses a dilemma for many clinicians due to its unknown etiology and largely unsuccessful treatment modalities. The purpose of this study was to compare the clinical results of 4 treatment modalities for CRPS type 1. A total of 59 patients were divided into 4 groups based on treatment modality: group A, an oral nonsteroidal anti-inflammatory drug (NSAID) (n=10); group B, oral gabapentin (n=12); group C, intravenous (IV) 10% mannitol and steroid (n=11); group D, a combination of IV 20% mannitol and steroid with oral gabapentin (n=26). The patients remained under medical supervision after discharge and were evaluated either once a month or once every 2 months until final follow-up at a mean of 8 m...<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>

Continuous subcutaneous infusion of lidocaine for persistent hiccup in advanced cancer.

We report a case of severe and sustained hiccup caused by gastric cancer that was successfully treated with a continuous subcutaneous infusion of lidocaine (480 mg (24 ml)/day) without severe side effects. PMID: 22661318 [PubMed - as supplied by publisher] (Source: Palliative Medicine)

Brain tumor-related epilepsy.

Authors: Maschio M Abstract In patients with brain tumor (BT), seizures are the onset symptom in 20-40% of patients, while a further 20-45% of patients will present them during the course of the disease. These patients present a complex therapeutic profile and require a unique and multidisciplinary approach. The choice of antiepileptic drugs is challenging for this particular patient population because brain tumor-related epilepsy (BTRE) is often drug-resistant, has a strong impact on the quality of life and weighs heavily on public health expenditures.In BT patients, the presence of epilepsy is considered the most important risk factor for long-term disability. For this reason, the problem of the proper administration of medications and their potential side effects is of great imp...

Gabapentin versus pregabalin in improving sleep quality and depression in hemodialysis patients with peripheral neuropathy: a randomized prospective crossover trial

Abstract Purpose&nbsp;&nbsp;In dialysis patients, painful peripheral neuropathy (PPN) is associated with sleep disturbance and mood disorders. Our goal was to compare the effects of gabapentin and pregabalin on improving sleep quality and depression among hemodialysis patients with PPN. Methods&nbsp;&nbsp;Fifty hemodialysis patients with PPN were randomized into 2 groups, to receive gabapentin and pregabalin, respectively. After 6&nbsp;weeks of treatment, patients underwent a 2-week washout period, followed by crossover and another 6&nbsp;weeks of treatment. All patients underwent electromyography (EMG) at the outset and completed the modified Short Form of McGill Pain Questionnaire (SF-MPQ), the Beck Depression Inventory (BDI) and the Pittsburgh Sleep Quality (PSQI) assessm...

Gabapentin reduces CX3CL1 signaling and blocks spinal microglial activation in monoarthritic rats

Conclusions: Here we provide the first evidence that gabapentin diminishes CX3CL1 signaling and spinalmicroglia activation induced by joint inflammation. We also show that the VGCC alpha2/delta-1subunits might be involved in these events. (Source: Molecular Brain)

Syncopal storm caused by glossopharyngeal neuralgia

We report a rare case presenting with up to 50 episodes of syncopes per day in a 54-year-old man with the ultimate diagnosis of idiopathic glossopharyngeal neuralgia. All episodes were started with a severe pain sensation in the right side of the throat followed by asystole and then very slow ventricular escape beats. The patient was successfully treated with the combination of carbamazepine, gabapentin, and dual-chamber pacemaker implantation. (Source: The American Journal of Emergency Medicine)<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>

Once-Daily Gabapentin Effective in Postherpetic PainOnce-Daily Gabapentin Effective in Postherpetic Pain

A once-daily formulation of gabapentin G-GR will relieve postherpetic neuralgia within 4 days -- or will not work at all, researchers say. Medscape Medical News (Source: Medscape Medical News Headlines)

German fibromyalgia consumer reports - a crosssectional survey

Conclusion: The German fibromyalgia consumer reports highlight the importance of non-pharmcological therapies in the long-term management of FMS, and challenges the strong recommendationsfor drug therapies given by FMS-guidelines. (Source: BMC Musculoskeletal Disorders)

Pain Alleviation and Patient-Reported Health Outcomes following Switching to Pregabalin in Individuals with Gabapentin-Refractory Neuropathic Pain in Routine Medical Practice

(Source: Clinical Drug Investigation)

Enantioselective synthesis of gabapentin analogues via organocatalytic asymmetric Michael addition of [small alpha]-branched aldehydes to [small beta]-nitroacrylates

Org. Biomol. Chem., 2012, Accepted ManuscriptDOI: 10.1039/C2OB25413A, PaperMasanori Yoshida, Erika Masaki, Hiroto Ikehara, Shoji HaraMichael addition reaction of [small alpha]-branched aldehydes to [small beta]-nitroacrylates was successfully carried out by using a mixed catalyst consisting of a primary amino acid, L-phenylalanine, and its lithium salt to give...The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Organic Biomolecular Chemistry)

Costs, work absence, and adherence in patients with partial onset seizures prescribed gabapentin or pregabalin

Conclusion: Despite higher acquisition costs for branded pregabalin over generic gabapentin, overall direct and indirect costs trended lower for pregabalin users. Additionally, pregabalin users had significantly fewer sick leave days and significantly higher adherence rates than gabapentin users. (Source: Epilepsy Research)<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>

GABAPENTIN (Gabapentin) Capsule [AvKARE, Inc.]

Updated Date: May 15, 2012 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

[Prophylactic medicines for migraine].

Authors: Stovner LJ, Tronvik E, Hagen K Abstract Migraine patients with frequent and disabling attacks should be given the opportunity to test prophylactic medicines, and general practitioners should know the indications and the main principles of treatment. When testing a preventative drug, it is important that the patient has realistic expectations, keeps a headache diary, increases the doses gradually, and takes an adequate dose for at least two months before the effect is assessed. Drugs licensed in Norway with adequate scientific documentation for use as migraine prophylactics include some antihypertensives (beta-blockers, candesartan and lisinopril), antiepileptics (topiramate, valproate and gabapentin), an antidepressant (amitriptyline), and botulinum toxin for chronic migra...

őĪ2őī expression sets presynaptic calcium channel abundance and release probability

&#945;2&#948; expression sets presynaptic calcium channel abundance and release probability Nature advance online publication 13 May 2012. doi:10.1038/nature11033 Authors: Michael B. Hoppa, Beatrice Lana, Wojciech Margas, Annette C. Dolphin & Timothy A. Ryan Synaptic neurotransmitter release is driven by Ca2+ influx through active zone voltage-gated calcium channels (VGCCs). Control of active zone VGCC abundance and function remains poorly understood. Here we show that a trafficking step probably sets synaptic VGCC levels in rats, because overexpression of the pore-forming &#945;1A VGCC subunit fails to change synaptic VGCC abundance or function. &#945;2&#948;s are a family of glycosylphosphatidylinositol (GPI)-anchored VGCC-associated subunits that, in addition to being the target o...

Gabapentin for Pruritus in Palliative Care.

Authors: Anand S Abstract Itch/pruritus can be very distressing in palliative care population and often is difficult to treat. Conventional antihistamines lack efficacy. Cutaneous and central pathogenesis of itch is extremely complex and unclear, making its treatment challenging. Neuronal mechanisms have been identified in the pathophysiology of itch hence providing a myriad of therapeutic options. It has been established that pruritus and pain neuronal pathway interact with each other, hence neuropathic analgesics like gabapentin has shown to be efficacious antipruritic therapeutic option. Gabapentin impedes transmitting nociceptive sensations to brain, thus also suppressing pruritus. Gabapentin is safe and found to be effective in uremic pruritus, cancer/hematologic causes, opiod...<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>

Treatments for diabetic neuropathy

Diabetic neuropathy comprises disorders of peripheral nerve in diabetes patients after exclusion of other disorders and can be focal or diffuse. The focal diabetic neuropathies tend to resolve spontaneously and are treated by reassurance, physiotherapy and analgesia for painful symptoms. Diabetic sensorimotor polyneuropathy (DSP) is the most frequent form of diabetic neuropathy and effective disease‚?źmodifying treatment is not available beyond the interventions of optimal glycemic control, and possibly lifestyle and risk factor modification. In contrast, a recent evidence‚?źbased guideline shows that effective treatments for painful DSP include: pregabalin, amitriptyline, duloxetine, venlafaxine, gabapentin, opioids, nitrate sprays, capsaicin, and transcutaneous electrical nerve stimulati...

Antinociceptive effects of gabapentin & its mechanism of action in experimental animal studies.

This study was undertaken to investigate experimentally whether gabapentin has analgesic effects in mice and rats. Methods: The mice were divided into 10 groups (n=7) with various treatments to assess central and peripheral antinociceptive activity of gabapentin. Hot plate, tail clip and tail flick tests were applied for the investigation of central antinociceptive activity and the writhing test was applied for the investigation of peripheral antinociceptive activity. In addition, we also evaluated the levels of PGE 2 and nNOS on perfused hippocampus slices of rats. Results: Gabapentin showed a peripheral antinociceptive effect at all doses and a central antinociceptive effect at 30mg/kg dose. While the L-NAME and cyproheptadine changed the central and peripheral effects of gabapentin, nal...

Chronic pain following spinal cord injury.

Authors: Rekand T, Hagen EM, Gr√łnning M Abstract Background. Chronic pain is common after a spinal cord injury, and may result in a substantially diminished quality of life. The aim of the paper is to provide an overview of pain conditions resulting from spinal cord injuries and an update on therapy options. Method. The article is based on a literature search in PubMed using the search words ¬ępain and spinal cord injury/injuries¬Ľ, ¬ęchronic pain and spinal cord injury/injuries¬Ľ and ¬ęneuropathic pain and spinal cord injury/injuries¬Ľ for the period 2006-2011. Some key articles on neuropathic pain are included. Results. Patients may develop nociceptive and/or neuropathic pain after a spinal cord injury. The cause, nature and location of the pain must be established before therap...

Digest

In conclusion, trial‚?źbased evidence suggests no clear and convincing advantage for cognitive behavioural therapy over other ‚?? and sometime much less sophisticated ‚?? therapies for people with schizophrenia.Cochrane Database of Systematic Reviews 2012, Issue 4. Art. No.: CD008712. DOI: 10.1002/14651858.CD008712.pub2 (Source: Progress in Neurology and Psychiatry)

New AAN Guidelines on Episodic Migraine PreventionNew AAN Guidelines on Episodic Migraine Prevention

Topiramate gets a new endorsement, while gabapentin and verapamil are downgraded, at least on the basis of the evidence available. Medscape Medical News (Source: Medscape Nurses Headlines)<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>

Anticonvulsant drug helps marijuana smokers kick the habit

Scientists have found clinical evidence that the drug gabapentin, currently on the market to treat neuropathic pain and epilepsy, helps people to quit smoking marijuana (cannabis). Unlike traditional addiction treatments, gabapentin targets stress systems in the brain that are activated by drug withdrawal. (Source: ScienceDaily Headlines)

Gabapentin: Acute renal failure in a child with renal impairment: case report

(Source: Reactions)

Effects of intraperitoneal administration of gabapentin on the minimum alveolar concentration of isoflurane in adult male rats

In conclusion, high-dose intraperitoneal gabapentin decreased isoflurane MAC. However, the effect was small and not dose-dependent, and is unlikely to be clinically significant. (Source: Laboratory Animals)

Drug treatment for spinal muscular atrophy types II and III.

CONCLUSIONS: There is no proven efficacious drug treatment for SMA types II and III. PMID: 22513940 [PubMed - in process] (Source: Cochrane Database of Systematic Reviews)

Treatment for cramps in amyotrophic lateral sclerosis/motor neuron disease.

CONCLUSIONS: There is no evidence to support the use of any intervention for muscle cramps in ALS/MND. More and larger randomised controlled trials evaluating treatments for muscle cramps in ALS/MND are needed. PMID: 22513921 [PubMed - in process] (Source: Cochrane Database of Systematic Reviews)<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>

HORIZANT (Gabapentin Enacarbil) Tablet, Extended Release [GlaxoSmithKline LLC]

Updated Date: Apr 20, 2012 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

The Effects of Gabapentin on Acute Opioid Tolerance to Remifentanil Under Sevoflurane Anesthesia in Rats.

Conclusions:Gabapentin reduced the sevoflurane MAC and enhanced the MAC reduction produced by remifentanil. This enhancement may limit AOT in rats. PMID: 22523419 [PubMed - as supplied by publisher] (Source: Anesthesia and Analgesia)

Antihyperalgesic Effects of Myrsinoic Acid B in Pain-Like Behavior Induced by Inflammatory and Neuropathic Pain Models in Mice.

Conclusions:MAB reduced mechanical and thermal hypersensitivity in mice submitted to models of inflammatory and neuropathic pain, showing excellent potential for treating persistent pain in humans. PMID: 22523418 [PubMed - as supplied by publisher] (Source: Anesthesia and Analgesia)

New Drug Application to be submitted FDA for Serada (extended-release gabapentin tablets) as treatment of menopausal hot flushes

Source: GlobeNewswire Area: News Depomed, Inc. is planning to submit a New Drug Application to the FDA in the second half of 2012 pending the outcome of a meeting with the Agency, for Serada (extended-release gabapentin tablets) for the management of menopausal hot flushes. The submission is based on three phase III trials, including the BREEZE 3 trial which noted positive and statistically significant findings for three of the four pre-specified primary endpoints of frequency and severity at four and 12 weeks. (Source: NeLM - News)

Multimodal analgesic treatment in video-assisted thoracic surgery lobectomy using an intraoperative intercostal catheter [THORACIC]

CONCLUSIONS Acute pain after VATS lobectomy may be adequately controlled using a multimodal non-opioid regime including PVB and an ICC. The low pain scores and reduced time used inserting the ICC may present an alternative to continuous epidural analgesia or conventional PVB. (Source: European Journal of Cardio-Thoracic Surgery)<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>

Nighttime Awakenings Responding to Gabapentin Therapy in Late Premenopausal Women: A Case Series

Insomnia related to nighttime awakenings is known to be more prevalent in women than men. Three cases are presented here of late premenopausal women experiencing frequent nighttime awakenings that responded well to bedtime treatment with gabapentin. In one case, what started as isolated nighttime awakenings slowly progressed to awakenings accompanied by typical menopausal night sweats. This led to the theory that the initial isolated nighttime awakenings in this patient may have been secondary to a menopausal etiology related to low serum estradiol levels. In the subsequent 2 cases, early follicular phase serum estradiol was confirmed to be low. It is theorized that isolated nighttime awakenings in some premenopausal women may be caused by low serum estradiol, triggering events physiologic...

A gastroretentive gabapentin formulation for the treatment of painful diabetic peripheral neuropathy: Efficacy and tolerability in a double-blind, randomized, controlled clinical trial

Conclusions: Once-daily G-GR was effective and well tolerated for the treatment of pain due to DPN. (Source: Diabetes Research and Clinical Practice)

NEURONTIN (Gabapentin) Capsule NEURONTIN (Gabapentin) Tablet, Film Coated NEURONTIN (Gabapentin) Solution [Parke-Davis Div Of Pfizer Inc]

Updated Date: Apr 3, 2012 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

The 2012 AHS/AAN Guidelines for Prevention of Episodic Migraine: A Summary and Comparison with other Recent Clinical Practice Guidelines

Abstract:Updated guidelines for the preventive treatment of episodic migraine have been issued by the American Headache Society (AHS) and the American Academy of Neurology (AAN). We summarize key 2012 guideline recommendations and changes from previous guidelines. We review the characteristics, methods, consistency and quality of the AHS/AAN guidelines in comparison with recently issued guidelines from other specialty societies.To accomplish this we reviewed the AHS/AAN guidelines and identified comparable recent guidelines through a systematic MEDLINE search. We extracted key data and summarized and compared the key recommendations and assessed quality using the Appraisal of Guidelines Research and Evaluation‚?źII tool. We identified two additional recent guidelines for migraine preventio...

Gabapentin and pregabalin-are they safe whilst breastfeeding?

Source: No information given Area: Evidence &#62; Medicines Q & A Gabapentin; Pregabalin; Lactation; Milk-human; Breastfeeding; breast milk (Source: NeLM - Medicines Q and A)<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>

HORIZANT (Gabapentin Enacarbil) Tablet, Extended Release [GlaxoSmithKline LLC]

Updated Date: Mar 23, 2012 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

Gabapentin Not Shown to Prevent Postherpetic Neuralgia [Correspondence]

(Source: Archives of Dermatology)

Gabapentin Not Shown to Prevent Postherpetic Neuralgia--Reply [Correspondence]

(Source: Archives of Dermatology)

Population Pharmacokinetics and Pharmacodynamics of Gabapentin After Administration of Gabapentin Enacarbil.

Authors: Lal R, Sukbuntherng J, Luo W, Tovera J, Lassauzet ML, Cundy KC Abstract Gabapentin enacarbil (GEn) is an actively transported prodrug of gabapentin that provides sustained dose-proportional exposure to gabapentin and predictable bioavailability. Gabapentin enacarbil is approved by the US Food and Drug Administration for the treatment of moderate-to-severe primary restless legs syndrome (RLS) in adults. Using plasma gabapentin concentration data obtained after administration of GEn in 12 phase 1 to 3 GEn studies in healthy adults or patients with RLS (dose range, 300-2400 mg/d), a population pharmacokinetic (PK) model was developed by nonlinear mixed-effect modeling using NONMEM. Data were similar in subjects with and without RLS. Population PK-pharmacodynamic (PD) models w...

Gabapentin/pregabalin: Drowsiness in an elderly patient: case report

(Source: Reactions)

Do Carbamazepine, Gabapentin, or Other Anticonvulsants Exert Sufficient Radioprotective Effects to Alter Responses From Trigeminal Neuralgia Radiosurgery?

Conclusions: The use of carbamazepine or gabapentin at the time of radiosurgery does not decrease the rates of obtaining partial or complete pain relief after radiosurgery, but gabapentin may reduce the risks of developing post-radiosurgery trigeminal neuropathy. (Source: International Journal of Radiation Oncology * Biology * Physics)

The Prevention of Chronic Postsurgical Pain Using Gabapentin and Pregabalin: A Combined Systematic Review and Meta-Analysis.

Conclusions:The present review supports the view that perioperative administration of gabapentin and pregabalin are effective in reducing the incidence of CPSP. Better-designed and appropriately powered clinical trials are needed to confirm these early findings. PMID: 22415535 [PubMed - as supplied by publisher] (Source: Anesthesia and Analgesia)

The Efficacy of Morphine, Pregabalin, Gabapentin, and Duloxetine on Mechanical Allodynia Is Different from That on Neuroma Pain in the Rat Neuropathic Pain Model.

Conclusions:These data indicate that the potency of morphine and the efficacy of pregabalin, gabapentin, and duloxetine on mechanical allodynia are different from those on neuroma pain and that combination therapy is one of different therapeutic choices for the treatment of neuropathic pain. PMID: 22415534 [PubMed - as supplied by publisher] (Source: Anesthesia and Analgesia)<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>

HORIZANT (Gabapentin Enacarbil) Tablet, Extended Release [GlaxoSmithKline LLC]

Updated Date: Mar 9, 2012 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

Alternative and complementary therapies for the menopause

This article seeks to review the evidence supporting non-hormonal approaches to treatment. There is only conflicting evidence at best to support alpha-2 agonists, e.g. clonidine and limited evidence for dihydroepiandrosterone and natural progesterones. There is limited randomized controlled trial data for gabapentin, selective norepinephrine re-uptake inhibitors (SNRIs) and selective serotonin re-uptake inhibitors (SSRIs), many of these studies being related to breast cancer patients. Of the herbal medicinal products, the largest evidence base rests with phytoestrogens. A Cochrane Database review looking at all types of phytoestrogens, e.g. red clover extracts, dietary soya and soya extracts concluded that there was no evidence to support improvement in climacteric symptoms and the meta-an...

Detection of 22 antiepileptic drugs by ultra-performance liquid chromatography coupled with tandem mass spectrometry applicable to routine therapeutic drug monitoring.

In conclusion, we developed a simple and selective UPLC-MS/MS method suitable for routine therapeutic monitoring of antiepileptics. Copyright © 2012 John Wiley & Sons, Ltd. PMID: 22383262 [PubMed - as supplied by publisher] (Source: Biomedical Chromatography : BMC)

A retrospective database analysis of neuropathic pain and oral antidiabetic medication use and adherence among Texas adults with type 2 diabetes enrolled in medicaid.

CONCLUSIONS: Overall, these data suggest that mean adherence to both PDPN and OAD medications was suboptimal (MPR &lt;80%). Patients who were adherent to PDPN medications were more adherent to OAD medications in the post-index period, but OAD medication adherence was independent of the type of PDPN medication used. OAD adherence decreased from pre- to post-index (ie, when patients were prescribed PDPN medications), which may indicate an opportunity for practitioners to emphasize the importance of OAD adherence in reducing the progression to neuropathy. PMID: 22386828 [PubMed - in process] (Source: Clinical Therapeutics)

A Proof-of-Concept Randomized Controlled Study of Gabapentin: Effects on Cannabis Use, Withdrawal and Executive Function Deficits in Cannabis-Dependent Adults

Authors: Barbara J Mason, Rebecca Crean, Vivian Goodell, John M Light, Susan Quello, Farhad Shadan, Kimberly Buffkins, Mark Kyle, Murali Adusumalli, Adnan Begovic & Santosh Rao Keywords: addiction & substance abuse; GABA; clinical pharmacology&#47;clinical trials; psychopharmacology; cannabis dependence; marijuana withdrawal; executive function; gabapentin; addiction treatment; controlled trial (Source: Neuropsychopharmacology)<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>

Pharmacokinetics and milk secretion of gabapentin and meloxicam co‚?źadministered orally in Holstein‚?źFriesian cows

This study was designed to determine specifically the depletion of these drugs into milk. Six animals received meloxicam at 1‚??mg/kg and gabapentin at 10‚??mg/kg, while another group (n‚??=‚??6) received meloxicam at 1‚??mg/kg and gabapentin at 20‚??mg/kg. Plasma and milk drug concentrations were determined over 7‚??days postadministration by HPLC/MS followed by noncompartmental pharmacokinetic analyses. The mean (¬ĪSD) plasma Cmax and Tmax for meloxicam (2.89‚??¬Ī‚??0.48‚??őľg/mL and 11.33‚??¬Ī‚??4.12‚??h) were not much different from gabapentin at 10‚??mg/kg (2.87‚??¬Ī‚??0.2‚??őľg/mL and 8‚??¬Ī‚??0‚??h). The mean (¬ĪSD) milk Cmax for meloxicam (0.41‚??¬Ī‚??80.16‚??őľg/mL) was comparable to gabapentin at 10‚??mg/kg (0.63‚??¬Ī‚??0.13‚??őľg/mL and 12‚??¬Ī‚??6.69‚??h). The mean plasma and m...

Determination of pharmaceuticals and antiseptics in water by solid-phase extraction and gas chromatography/mass spectrometry: analysis via pentafluorobenzylation and stable isotope dilution.

Authors: Yu JT, Bisceglia KJ, Bouwer EJ, Roberts AL, Coelhan M Abstract A sensitive yet robust analytical method is presented for the simultaneous determination of 12 human pharmaceuticals (valproic acid, phenytoin, ibuprofen, gabapentin, acetaminophen, gemfibrozil, naproxen, ketoprofen, secobarbital, phenobarbital, 5-fluorouracil, and diclofenac) and 6 antiseptics (biosol, biphenylol, p-chloro-m-cresol, p-chloro-m-xylenol, chlorophene, and triclosan). The method employs solid-phase extraction (SPE) followed by a novel pentafluorobenzylation using a mixture of acetontrile/water (1/1, v/v). The method is simple to perform (derivatization can be completed in a single test tube) and eliminates the need for any solvent/SPE cartridge drying or blow-down. It affords excellent resolution,...

Gabapentin use in the prevention of succinylcholine-induced fasciculation and myalgia

ML Rayhill, MD PerloffJournal of Postgraduate Medicine 2012 58(1):1-2 (Source: Journal of Postgraduate Medicine)

Prophylactic use of gabapentin for prevention of succinylcholine-induced fasciculation and myalgia: A randomized, double-blinded, placebo-controlled study

Conclusions: Prophylactic use of gabapentin 600 mg in laparoscopic cholecystectomy decreases the incidence and severity of myalgia and fentanyl consumption. (Source: Journal of Postgraduate Medicine)

The Effects of Gabapentin on Acute and Chronic Postoperative Pain After Coronary Artery Bypass Graft Surgery

We read with interest the article by Ucak et al on the effects of gabapentin on acute and chronic postoperative pain after coronary artery bypass graft surgery; however, there are some points that deserve comment. (Source: Journal of Cardiothoracic and Vascular Anesthesia)<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>

Response to Drs Graterol and Linter

We would like to thank Drs Graterol and Linter for their suggestions on our study about the effects of gabapentin on postoperative pain after cardiac surgery. As stated in the Methods section of our study, all patients had 50 mg of oral tramadol hydrochloride every 12 hours and 500 mg of paracetamol (acetaminophen) every 8 hours for the 1st and 2nd postoperative days. During this period, 1 mg/kg of intravenous tramadol was delivered as the rescue medication if the visual analog scale score was above 4. (Source: Journal of Cardiothoracic and Vascular Anesthesia)

Metformin-associated Lactic Acidosis Masquerading as Ischemic Bowel

A 69-year-old male inpatient on the psychiatric ward developed abdominal pain, nausea, non-bloody emesis, and diaphoresis shortly after eating. His medical history included depression, coronary artery disease, diabetes mellitus, and dyslipidemia. His medications included clopidogrel, gabapentin, glipizide, lisinopril, metformin, metoprolol, omeprazole, rosuvastatin, and sertraline. He denied overdosing on any medications. His vital signs were a heart rate of 74 beats/min, temperature of 36.2¬įC, respiratory rate of 24 breaths/min, and blood pressure of 82/52 mm Hg. The examination revealed decreased bowel sounds, voluntary guarding, and tenderness to palpation in the lower abdomen, which appeared out of proportion to the physical examination. A rectal examination revealed impacted stool an...

Gabapentin reduces postoperative discomfort in bladder cancer

Pretreatment with gabapentin reduces postoperative catheter-related discomfort in patients undergoing transurethral surgery for bladder cancer, study results show. (Source: MedWire News - Urology)

GRALISE (Gabapentin) Tablet, Film Coated GRALISE STARTER PACK (Gabapentin) Kit [Depomed, Inc.]

Updated Date: Feb 15, 2012 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>

Effective and clinically meaningful non-hormonal hot flash therapies

Abstract: Although many non-hormonal compounds have shown statistically significant benefit over placebo in hot flash randomized controlled trials (RCTs), these studies have varied considerably in basic methodology making it challenging to deduce which compounds have the greatest potential to provide clinically meaningful benefit. This review used evidence-based methodology closely mirroring the FDA and EMEA guidelines as a template to identify ‚??well-designed‚?Ě RCTs from which effective and clinically meaningful non-hormonal hot flash therapies could be identified. In addition, pertinent safety information was reviewed. Out of 3548 MEDLINE citations and abstracts, 51 well-designed hot flash RCTs were identified. From these trials, gabapentin, oxybutynin ER, desvenlafaxine, soy-derived i...

Gabapentin reduces postoperative discomfort in bladder cancer

Pretreatment with gabapentin reduces postoperative catheter-related discomfort in patients undergoing transurethral surgery for bladder cancer, study results show. (Source: MedWire News - Oncology)

Antiallodynia and antihyperalgesia effects of ceftriaxone in treatment of chronic neuropathic pain in rats

Conclusion: The results suggest that ceftriaxone as a modulator of glutamate uptake could provide beneficial effects in the treatment of chronic neuropathic pain, especially allodynia that is less sensitive to the most available drugs. (Source: Acta Neuropsychiatrica)

054 Can randomised controlled trial data from non-epilepsy indications be included in meta-analysis for AEDs used in epilepsy? An analysis of adverse event data

Conclusion AEs of AEDs from non-epilepsy trials could be used in meta-analysis due to low statistical heterogeneity for some interventions and outcomes. Nevertheless this was not the case in all AEDs or outcomes. Effect sizes were larger in the non-epilepsy indications overall. (Source: Journal of Neurology, Neurosurgery and Psychiatry)

Efficacy of Gabapentin for Prevention of Postoperative Catheter-related Bladder Discomfort in Patients Undergoing Transurethral Resection of Bladder Tumor

Conclusion: Gabapentin 1200 mg administered before surgery is more effective than gabapentin 600 mg in decreasing the incidence of postoperative CRBD. (Source: Urology)<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>

Peripheral neuropathy response to erythropoietin in type 2 diabetic patients with mild to moderate renal failure

This study assessed the added effect of 6 months of erythropoietin (EPO) administration in patients suffering from diabetic neuropathy with mild to moderate chronic kidney disease (CKD) managed with gabapentin.Twenty diabetic patients with mild to moderate CKD were included; 12 in gabapentin and 8 in EPO+gabapentin group. The subjects underwent nerve conduction studies (NCS) at the initiation of the investigation and after 6-month treatment. NCS were made in deep and superficial peroneal, tibial, and sural nerves.After 6 months, in both the groups, proximal motor latency (PML) nonsignificantly improved in deep peroneal and tibial nerves; conversely, dorsal motor latency (DML) got slightly impaired in these two nerves. A nonsignificant disruption and improvement was observed in deep peronea...

Analgesic effects of preoperative gabapentin after tongue reconstruction with the anterolateral thigh flap.

CONCLUSION. Single preoperative doses of gabapentin led to significant reductions in postoperative pain and nausea with reduced analgesic and antiemetic usage, without additional side-effects or increases in operative complications. PMID: 22302908 [PubMed - in process] (Source: Hong Kong Med J)

Antiallodynia and antihyperalgesia effects of ceftriaxone in treatment of chronic neuropathic pain in rats

Conclusion: The results suggest that ceftriaxone as a modulator of glutamate uptake could provide beneficial effects in the treatment of chronic neuropathic pain, especially allodynia that is less sensitive to the most available drugs. (Source: Acta Neuropsychiatrica)

Assessment of prescribers' knowledge of the cost of medications.

CONCLUSIONS: Prescribers are more likely to know the cost of medications for patients who have prescription insurance coverage versus those who do not. PMID: 22318929 [PubMed - in process] (Source: The Annals of Pharmacotherapy)

Gabapentin enacarbil for treatment of restless legs syndrome in adults.

CONCLUSIONS: Clinical trials have evaluated gabapentin enacarbil for safety and efficacy in treating moderate-to-severe RLS symptoms for up to 64 weeks. It offers a pharmacokinetic advantage over gabapentin by having improved absorption and a longer duration of action, but clinically significant differences are yet to be determined. Potential disadvantages of gabapentin enacarbil include cost, concerns of suicide risk and pancreatic cancer, and a lack of data for the FDA-approved 600-mg dosage. Overall, gabapentin enacarbil is a viable therapeutic option for adults with moderate-to-severe RLS for whom more conventional therapies have failed. PMID: 22298601 [PubMed - in process] (Source: The Annals of Pharmacotherapy)<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>

Evaluation of Gabapentin Enacarbil on Cardiac Repolarization: A Randomized, Double-Blind, Placebo- and Active-Controlled, Crossover Thorough QT/QTc Study in Healthy Adults.

CONCLUSION: In this population of healthy adults, gabapentin enacarbil at doses of 1200 and 6000 mg was not associated with QT prolongation and was generally well-tolerated. PMID: 22325733 [PubMed - in process] (Source: Clinical Therapeutics)

Pharmacokinetics and milk secretion of gabapentin and meloxicam co‚?źadministered orally in Holstein‚?źFriesian cows

This study was designed to determine specifically the depletion of these drugs into milk. Six animals received meloxicam at 1‚??mg/kg and gabapentin at 10‚??mg/kg, while another group (n‚??=‚??6) received meloxicam at 1‚??mg/kg and gabapentin at 20‚??mg/kg. Plasma and milk drug concentrations were determined over 7‚??days postadministration by HPLC/MS followed by noncompartmental pharmacokinetic analyses. The mean (¬ĪSD) plasma Cmax and Tmax for meloxicam (2.89‚??¬Ī‚??0.48‚??őľg/mL and 11.33‚??¬Ī‚??4.12‚??h) were not much different from gabapentin at 10‚??mg/kg (2.87‚??¬Ī‚??0.2‚??őľg/mL and 8‚??¬Ī‚??0‚??h). The mean (¬ĪSD) milk Cmax for meloxicam (0.41‚??¬Ī‚??80.16‚??őľg/mL) was comparable to gabapentin at 10‚??mg/kg (0.63‚??¬Ī‚??0.13‚??őľg/mL and 12‚??¬Ī‚??6.69‚??h). The mean plasma and m...

Neuromodulators for pain management in rheumatoid arthritis

Source: Cochrane Library Area: Evidence &#62; Drug Class Focused Reviews Background Pain management is a high priority for patients with rheumatoid arthritis (RA). Despite deficiencies in research data, neuromodulators have gained widespread clinical acceptance as adjuvants in the management of patients with chronic musculoskeletal pain. &#160; &#160; Objectives The aim of this review was to determine the efficacy and safety of neuromodulators in pain management in patients with RA. Neuromodulators included in this review were anticonvulsants (gabapentin, pregabalin, phenytoin, sodium valproate, lamotrigine, carbamazepine, levetiracetam, oxcarbazepine, tiagabine and topiramate), ketamine, bupropion, methylphenidate, nefopam, capsaicin and the cannabinoids. &#160; Search ...

Psychopathological dimensions of tinnitus and psychopharmacologic approaches in its treatment

Conclusion: When pathophysiologic reasons are excluded, it should be at least considered that tinnitus is exaggerated by psychopathological symptoms. Life quality of patients can be increased by treating these symptoms. (Source: General Hospital Psychiatry)

Neuromodulators for pain management in rheumatoid arthritis.

CONCLUSIONS: There is currently weak evidence that oral nefopam, topical capsaicin and oromucosal cannabis are all superior to placebo in reducing pain in patients with RA. However, each agent is associated with a significant side effect profile. The confidence in our estimates is not strong given the difficulties with blinding, the small numbers of participants evaluated and the lack of adverse event data. In some patients, however, even a small degree of pain relief may be considered worthwhile. Until further research is available, given the relatively mild nature of the adverse events, capsaicin could be considered as an add-on therapy for patients with persistent local pain and inadequate response or intolerance to other treatments. Oral nefopam and oromucosal cannabis have more signif...<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>

Pain‚??s peptide signature

Chronic pain, and especially persistent pain caused by an identifiable lesion to the nervous system (neuropathic pain), is a clinical concern of intense ongoing research. There is clearly a need for improved therapies. Multiple mechanisms have been discovered and illuminated within this field (reviewed in ) and medical research has in a few notable cases, such as gabapentin, resulted in tangible benefit . Much work remains, however, in order that the mechanisms that underlie the generation of neuropathic pain can be elucidated and novel therapies developed rationally. Within the last few decades, genomic science has been added to the tool box of methods that can be used to define and understand this disease. Among these methods are cloning, transcript abundance quantification, genetic trai...

Treatments for Methamphetamine Abuse: A Literature Review for the Clinician

The objective of this article is to critically review the literature of METH treatment options. Preclinical research and human research with compounds not yet available commercially in the United States will not be included. A literature review was conducted for research on pharmacological treatments for METH use and addiction. Trial information on the use of sertraline, bupropion, mirtazapine, modafinil, dextroamphetamine, ondansetron, risperidone, aripiprazole, baclofen, and gabapentin was reviewed. Aripiprazole trials appeared in the reviewed literature more frequently than the other medications. Based on the findings of this review, no single medication demonstrated consistent efficacy and each trial contained a variety of methodological limitations. (Source: Journal of Pharmacy Practi...

Post burn pruritus‚??A review of current treatment options

Abstract: Post burn pruritus is a well recognised symptom in almost all burn patients. Yet, there is insufficient awareness about the etiopathogenesis and a lack of a systematic approach in the assessment and treatment of this distressing symptom. The current standard therapies include antihistamines, which are effective as sole therapy in only 20% patients, and emollients. There is a lacunae of clear consensus on the care of patients not responding to antihistamines. We review the literature on the etiology and pathogenesis of post burn pruritus, which has both central and peripheral pathways. The published studies on the currently available therapeutic options to treat itch in burns are discussed. On the basis of current evidence in literature, gabapentin used in the treatment of neuropa...

Evaluation of efficacy and safety of gabapentin, duloxetine, and pregabalin in patients with painful diabetic peripheral neuropathy

Conclusions: Monotherapy with GBP, DLX, or PGB Produced a clinically and subjectively meaningful pain relief in patients with DPNP with onset of pain relief being faster and superior with PGB. (Source: Indian Journal of Pharmacology)

[Multiple mononeuritis and eosinophilic fasciitis in a patient with idiopathic hypereosinophilic syndrome].

CONCLUSIONS. The patient, in accordance with current criteria, presented idiopathic hypereosinophilic syndrome with an undetermined subtype. To our knowledge, the association with eosinophilic fasciitis and multineuritis has not been reported to date. There is no proven infiltrating mechanism in multiple mononeuritis, which corroborates the poor control of the neuropathic clinical symptoms with oral corticoid therapy. Association with gabapentin, which stabilises the axonal membrane, also backs up the neurotoxic pathogenetic hypothesis. PMID: 22234568 [PubMed - in process] (Source: Revista de Neurologia)<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>

GABAPENTIN (Gabapentin ) Capsule [Lake Erie Medical Surgical Supply DBA Quality Care Products LLC]

Updated Date: Jan 5, 2012 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

Sacral nerve modulation in the treatment of chronic pelvic pain

Conclusions&nbsp;&nbsp;Sacral neuromodulation proved to be effective in the treatment of some patients affected by chronic pelvic pain, and the effect persists over time. A positive screening phase and a positive response to gabapentin or pregabalin showed to be predictors of a successful response. Multiple localizations of pelvic pain and pain occurred after stapler surgery seem to be negative factors for the success of the treatment. Content Type Journal ArticleCategory Original ArticlePages 1-6DOI 10.1007/s00384-011-1394-2Authors J. Martellucci, General Surgery I, University of Siena, Ospedale Le Scotte viale Bracci, 1, 53100 Siena, ItalyG. Naldini, General Surgery IV, University Hospital of Pisa, Pisa, ItalyA. Carriero, Pelvic Floor Center, Montecchio Emilia, Italy ...

Clinical Pharmacokinetics of Gabapentin After Administration of Gabapentin Enacarbil Extended-Release Tablets in Patients With Varying Degrees of Renal Function Using Data From an Open-Label, Single-Dose Pharmacokinetic Study.

CONCLUSIONS: The data suggest that dosage adjustment for gabapentin enacarbil is necessary in patients with impaired renal function. Gabapentin enacarbil, 600 mg, seemed to be well tolerated in this small selected population. PMID: 22206794 [PubMed - as supplied by publisher] (Source: Clinical Therapeutics)

Riluzole and gabapentinoids activate glutamate transporters to facilitate glutamate-induced glutamate release from cultured astrocytes.

Authors: Yoshizumi M, Eisenach JC, Hayashida KI Abstract We have recently demonstrated that the glutamate transporter activator riluzole paradoxically enhanced glutamate-induced glutamate release from cultured astrocytes. We further showed that both riluzole and the őĪ(2)őī subunit ligand gabapentin activated descending inhibition in rats by increasing glutamate receptor signaling in the locus coeruleus and hypothesized that these drugs share common mechanisms to enhance glutamate release from astrocytes. In the present study, we examined the effects of riluzole and gabapentin on glutamate uptake and release and glutamate-induced Ca(2+) responses in primary cultures of astrocytes. Riluzole and gabapentin facilitated glutamate-induced glutamate release from astrocytes and significan...

Pharmacologic interventions for treating phantom limb pain.

CONCLUSIONS: The short- and long-term effectiveness of opioids, NMDA receptor antagonists, anticonvulsants, antidepressants, calcitonins, and anaesthetics for clinically relevant outcomes that include pain, function, mood, sleep, quality of life, satisfaction and adverse effects remains unclear. Morphine, gabapentin and ketamine demonstrate trends towards short-term analgesic efficacy. Memantine and amitriptyline were ineffective for PLP. Results, however, are to be interpreted with caution as these were based mostly on a small number of studies with limited sample sizes that varied considerably and also lacked long-term efficacy and safety outcomes. The direction of efficacy of calcitonin, anaesthetics and dextromethorphan need further clarification. Larger and more rigorous randomised co...<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>

Drug treatment for spinal muscular atrophy types II and III.

CONCLUSIONS: There is no proven efficacious drug treatment for SMA types II and III. PMID: 22161400 [PubMed - in process] (Source: Cochrane Database of Systematic Reviews)

HORIZANT (Gabapentin Enacarbil) Tablet, Extended Release [GlaxoSmithKline LLC]

Updated Date: Dec 16, 2011 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

Pharmacologic Prophylaxis for Acute Mountain Sickness: A Systematic Shortcut Review

Conclusion: Acetazolamide is effective for the prevention of acute mountain sickness but may be associated with paresthesias. Sumatriptan and gabapentin are beneficial but require further study. (Source: Annals of Emergency Medicine)

Treatment of Meralgia Paresthetica with Ultrasound‚?źGuided Pulsed Radiofrequency Ablation of the Lateral Femoral Cutaneous Nerve

Abstract:‚?? A 23‚?źyear‚?źold female with an 18‚?źmonth history of left anterolateral thigh paresthesias and burning pain consistent with meralgia paresthetica was referred to our clinic after failing trials of physical therapy, nonsteroidal anti‚?źinflammatories, gabapentin, and amitriptyline. We performed 3 lateral femoral cutaneous nerve blocks with corticosteroid over a 4‚?źmonth period; however, each block provided only temporary relief. As this pain was limiting the patient‚??s ability to perform her functions as an active duty service member, we elected to perform a pulsed radiofrequency treatment of the lateral femoral cutaneous nerve with ultrasound guidance and nerve stimulation. After locating the lateral femoral cutaneous nerve with ultrasound and reproducing the patient‚??s d...

GABAPENTIN Capsule [Lake Erie Medical DBA Quality Care Products LLC]

Updated Date: Dec 5, 2011 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>

False Claims Act Prosecution Did Not Deter Off-Label Drug Use In The Case Of Neurontin [Pharmaceuticals]

Since 2004 the United States has collected approximately $8&nbsp;billion from fraud enforcement actions against pharmaceutical manufacturers accused under the federal False Claims Act of illegally promoting drugs for off-label uses. Using the case of gabapentin (Neurontin), a drug approved for epilepsy but prescribed for a variety of conditions, we sought to determine whether the enforcement action also influenced off-label prescribing rates. We conducted a segmented time-series analysis using key legal milestones: the initiation of a sealed investigation, public announcement of the investigation, and settlement of the case. Off-label use grew steadily until settlement, when gabapentin prescriptions declined for both off-label and on-label indications. Because enforcement actions targeting...

Gabapentin: A novel drug as add-on therapy in cases of refractory overactive bladder in children

Abstract: Objective: To determine the effectiveness of gabapentin as an add-on therapy in children presenting with overactive bladder (OAB) not responding to conventional anticholinergics.Materials and methods: Children with refractory OAB were included prospectively from March 2009 to February 2010. The inclusion criterion was persistence of symptoms while on conventional anticholinergics for 6 months. Gabapentin was prescribed as an add-on therapy. The patients were followed 4 weekly with bladder diary and urodynamic study was repeated at 3 months.Results: There were 31 children, 26 of neurogenic OAB and 5 of non-neurogenic origin. Mean¬ĪSD age was 8.5¬Ī5.3 years. Data were analyzed in 30 patients as treatment was terminated in 1 due to adverse effects. Continence improved in 16 (53.3%) ...

Med Sci Monit 2011; 17(12):CS149-151 &quot;Gabapentin in the treatment of dementia-associated nocturnal agitation&quot;

Conclusions: Gabapentin was very effective in treating nocturnal agitation. (Source: Medical Science Monitor)

Risk of cancer in patients exposed to gabapentin in two electronic medical record systems

ConclusionsThe epidemiological data in a US cohort with up to 12‚??years of follow‚?źup and a UK cohort with up to 15‚??years of follow‚?źup do not support a carcinogenic effect of gabapentin use. However, the confidence intervals for some analyses were wide, and an important effect cannot be confidently excluded. Copyright ¬© 2011 John Wiley & Sons, Ltd. (Source: Pharmacoepidemiology and Drug Safety)

Perioperative administration of gabapentin 1,200 mg day-1 and pregabalin 300 mg day-1 for pain following lumbar laminectomy and discectomy: a randomised, double-blinded, placebo-controlled study.

Conclusion: This study showed that both pregabalin 300 mg day-1 and gabapentin 1,200 mg day-1 have more analgesic, anxiolytic and opioid-sparing effects, higher patient satisfaction and are more effective for preventing postoperative shivering than the placebo following lumbar laminectomy and discectomy. The findings revealed that pregabalin 300 mg day-1 had equivalent analgesic, adverse and opioidsparing effects and patient satisfaction as gabapentin 1,200 mg day-1. PMID: 22159931 [PubMed - in process] (Source: Singapore Medical Journal)<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>

Effect of pre-emptive gabapentin on postoperative pain following lower extremity orthopaedic surgery under spinal anaesthesia.

Conclusion: Pre-emptive use of gabapentin 300 mg orally significantly decreases postoperative pain two hours after surgery. PMID: 22159930 [PubMed - in process] (Source: Singapore Medical Journal)

Biphasic effects of chronic intrathecal gabapentin administration on the expression of protein kinase C gamma in the spinal cord of neuropathic pain rats.

CONCLUSIONS: Our results indicate that chronic intrathecal gabapentin has beneficial effects on the behaviors of both thermal and mechanical stimulations in the neuropathic pain animals and the NMDA blocker can potentiate this effect. Furthermore, gabapentin has biphasic effect on the expression of PKCő≥ in the spinal cord on Day 7 and Day 14 for the model rats with CCI. PMID: 22221687 [PubMed - in process] (Source: Acta Anaesthesiologica Taiwanica)

Possible GABAergic mechanism in the neuroprotective effect of gabapentin and lamotrigine against 3-nitropropionic acid induced neurotoxicity.

Authors: Kumar P, Kalonia H, Kumar A Abstract Huntington's disease is a progressive neurodegenerative disorder that gradually reduces memory, cognitive skills and normal movements of affected individuals. Systemic administration of 3-Nitropropionic acid induces selective striatal lesions in rodents and non-human primates. Therefore, the present study has been designed to elucidate the comparative mechanistic profile of gabapentin, lamotrigine and their interactions with GABAergic modulators against 3-Nitropropionic acid induced neurotoxicity. Systemic 3-Nitropropionic acid (10mg/kg) administration for 14days significantly reduced body weight, locomotor activity, grip strength, oxidative defense (LPO, nitrite, SOD and catalase) and impaired mitochondrial complex enzyme (I, II, IV an...

How can hot flushes in men being treated for prostate cancer be managed?

Source: London Medicines Information Service Area: Evidence &#62; Medicines Q & A There are a number of treatments which have been studied for the treatment of hot flushes in men undergoing androgen deprivation therapy, most are unlicensed for this indication, such as clonidine, gabapentin, medroxyprogesterone acetate, megestrol and SSRIs, while cyproterone is licensed for this.&#160; This Q&#38;A discusses the use of these treatments. There are few well designed, randomised studies. Some data come from smaller open-label or pilot studies or case reports, which were not placebo-controlled and have not been well reported. &#160; Many of the studies are short, do not carry the strength of a longer, prospective, randomised, placebo-controlled trial and may prevent firm conclusions be...

Pathophysiology of freezing of gait and some possible treatments for it

In this study, we used the model of PD gait behavior for comparing normal and PD persons in order to simulate FOG and find its pathophysiology and probable treatments. We observed in the adapted model that the dopaminergic weights were reduced and the amount of dopaminergic bias was increased. These findings show that the aggravation of the disease and severe resistance of neurons to dopamine agonists may be the main cause of the FOG. Based on our model three therapeutic strategies may be proposed: decreasing the cortex signal to basal ganglia, using high dose glutamate antagonist, and using less glutamate antagonist with some amounts of gabapentin. (Source: Medical Hypotheses)<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>

GABAPENTIN (Gabapentin) Tablet [Med-Health Pharma LLC]

Updated Date: Nov 23, 2011 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

Amitriptyline/gabapentin/pregabalin: Falls, dizziness and drowsiness in elderly patients: 3 case reports

(Source: Reactions)

Newly diagnosed epileptic seizures: Focus on an elderly population on the French island of Réunion in the Southern Indian Ocean

We describe an elderly population with newly diagnosed epileptic seizures using data from the EPIREUN study conducted between July 1, 2004 and June 30, 2005. The methodology is described in detail in the EPIREUN study report (Mignard et¬†al., 2009).Key Findings:‚?? There were 153 single unprovoked seizures (84.1%); their incidence was 278.1 [95% confidence interval (CI) 237.4‚??325.9] per 100,000. The incidence of newly diagnosed epilepsy was 125.4 (95% CI, 99.1‚??158.8) per 100,000. Twenty‚?źeight acute symptomatic seizures occurred (15.4%); the incidence was 50.9 (95% CI 35.1‚??73.7) per 100,000. The annual incidence of newly diagnosed epileptic seizure in the elderly was 330.8 (95% CI 286.1‚??382.6) per 100,000: 403.0 (95% CI 328.5‚??494.3) per 100,000 in men and 279.6 (95% CI, 227.4‚??...

Double‚?źblind placebo‚?źcontrolled evaluation of the PROMETA‚?Ę protocol for methamphetamine dependence

Conclusions‚?? The PROMETA protocol, consisting of flumazenil, gabapentin and hydroxyzine, appears to be no more effective than placebo in reducing methamphetamine use, retaining patients in treatment or reducing methamphetamine craving. (Source: Addiction)

Systematic Review and Meta-Analysis of Efficacy, Safety, and Tolerability Data from Randomized Controlled Trials of Drugs Used to Treat Postherpetic Neuralgia (December).

CONCLUSIONS:While available literature establishes the efficacy of 8 drugs in treatment of PHN, it does not provide adequate guidance as to which agents are best to treat this condition, in part because of inadequate reporting of data on tolerability and safety. PMID: 22085778 [PubMed - as supplied by publisher] (Source: The Annals of Pharmacotherapy)<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>

Persistent hiccup after surgical resection of a brainstem arteriovenous malformation: a case successfully treated with gabapentin during rehabilitation. Case report.

We present a case of persistent hiccup after surgical resection of a brainstem arteriovenous malformation successfully treated with gabapentin during rehabilitation. PMID: 22083264 [PubMed - as supplied by publisher] (Source: European Journal of Physical and Rehabilitation Medicine)

Perimenopausal migraine in women with vasomotor symptoms

Abstract: Migraine is affected by fluctuating estrogen levels so it is not surprising that the perimenopause is a time of peak rate of change of migraine prevalence in women. Evidence supports estrogen ‚??withdrawal‚?? as one of the important triggers of menstrual attacks of migraine without aura, while high levels are associated with migraine aura. This mini review addresses the issues of diagnosing migraine, treating the symptoms of migraine, and controlling co-morbid migraine and hot flushes with hormonal and non-hormonal options. Maintaining a stable estrogen environment is the most effective treatment for vasomotor symptoms and can also benefit estrogen-withdrawal migraine. Using only the lowest doses necessary to control symptoms minimizes the risk of unwanted side effects. Non-hormo...

Treatment of Nystagmus

Opinion statement&nbsp;&nbsp;Patients with congenital and acquired forms of nystagmus are commonly encountered in clinical practice. Many report visual symptoms, such as oscillopsia and blurred vision, which can be alleviated if the nystagmus can be suppressed. Pharmacologic, optical, and surgical treatments are available, with the choice of treatment depending on the characteristics of the nystagmus and the severity of the associated visual symptoms. Downbeat nystagmus can be treated with 4-aminopyridine, 3,4-diaminopyridine, or clonazepam. Upbeat nystagmus can be reduced with memantine, 4-aminopyridine, or baclofen. Torsional nystagmus may respond to gabapentin. Acquired pendular nystagmus in patients with multiple sclerosis is often partially suppressed by gabapentin or memantine....

Why still in hospital after fast-track hip and knee arthroplasty?

Authors: Husted H, Lunn TH, Troelsen A, Gaarn-Larsen L, Kristensen BB, Kehlet H Abstract Background and purpose Length of stay (LOS) following total hip and knee arthroplasty (THA and TKA) has been reduced to about 3 days in fast-track setups with functional discharge criteria. Earlier studies have identified patient characteristics predicting LOS, but little is known about specific reasons for being hospitalized following fast-track THA and TKA. Patients and methods To determine clinical and logistical factors that keep patients in hospital for the first postoperative 24?72 hours, we performed a cohort study of consecutive, unselected patients undergoing unilateral primary THA (n = 98) or TKA (n = 109). Median length of stay was 2 days. Patients were operated with spinal anesthes...

Evidence-based guideline update: Treatment of essential tremor: Report of the Quality Standards Subcommittee of the American Academy of Neurology

Conclusions and recommendations for the use of propranolol, primidone (Level A, established as effective); alprazolam, atenolol, gabapentin (monotherapy), sotalol, topiramate (Level B, probably effective); nadolol, nimodipine, clonazepam, botulinum toxin A, deep brain stimulation, thalamotomy (Level C, possibly effective); and gamma knife thalamotomy (Level U, insufficient evidence) are unchanged from the previous guideline. Changes to conclusions and recommendations from the previous guideline include the following: 1) levetiracetam and 3,4-diaminopyridine probably do not reduce limb tremor in ET and should not be considered (Level B); 2) flunarizine possibly has no effect in treating limb tremor in ET and may not be considered (Level C); and 3) there is insufficient evidence to support o...<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>

Gabapentin and sexual dysfunction: An overlooked and underreported problem?

Authors: Calabrò RS PMID: 22056815 [PubMed - as supplied by publisher] (Source: Epilepsy and Behaviour)

GABAPENTIN (Gabapentin) Capsule [Med-Health Pharma, LLC]

Updated Date: Nov 3, 2011 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

Role of gabapentin in preventing fentanyl- and morphine-withdrawal-induced hyperalgesia in rats

Conclusions&nbsp;&nbsp;The study showed that gabapentin can significantly prevented opioid-induced hyperalgesia (OIH) induced caused by fentanyl and morphine, suggesting a role for the addition of gabapentin in the perioperative period and during chronic pain treatment as an effective drug to prevent OIH. Content Type Journal ArticleCategory Original ArticlePages 1-6DOI 10.1007/s00540-011-1272-7Authors Xin Wei, Department of Anesthesiology, Anhui Medical University Affiliated Auhui Provincial Hospital, 230001 Hefei, People‚??s Republic of ChinaWei Wei, Institute of Clinical Pharmacology, Anhui Medical University Key Laboratory of Antiinflammatory and Immunopharmacology, Ministry of Education, 230032 Hefei, People‚??s Republic of China Journal Journal of AnesthesiaOnline...

Generic substitution of antiepileptic drugs: a systematic review of prospective and retrospective studies.

CONCLUSIONS: There is inconsistency between retrospective and prospective studies of generic AED substitution. The highest levels of evidence indicate that there should not be a problem with generic substitution, although some patients are more prone to problems with the generic products. Some evidence suggests that switches between multiple generic AED products in certain individuals may be problematic. PMID: 22028417 [PubMed - in process] (Source: The Annals of Pharmacotherapy)

Gabapentin Improves Hot Flashes, Sleep Post Menopause

Major Finding: The mean difference in the global PSQI sleep scores, compared with a placebo, after 4 weeks of treatment was ‚??1.74 in women who took 1,200 mg of gabapentin daily and ‚??1.68 in women who took 1,800 mg daily; the differences were significant for both doses, compared with a placebo. (Source: Clinical Endocrinology News)<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>

Treatment of Meralgia Paresthetica with Ultrasound‚?źGuided Pulsed Radiofrequency Ablation of the Lateral Femoral Cutaneous Nerve

Abstract:‚?? A 23‚?źyear‚?źold female with an 18‚?źmonth history of left anterolateral thigh paresthesias and burning pain consistent with meralgia paresthetica was referred to our clinic after failing trials of physical therapy, nonsteroidal anti‚?źinflammatories, gabapentin, and amitriptyline. We performed 3 lateral femoral cutaneous nerve blocks with corticosteroid over a 4‚?źmonth period; however, each block provided only temporary relief. As this pain was limiting the patient‚??s ability to perform her functions as an active duty service member, we elected to perform a pulsed radiofrequency treatment of the lateral femoral cutaneous nerve with ultrasound guidance and nerve stimulation. After locating the lateral femoral cutaneous nerve with ultrasound and reproducing the patient‚??s d...

[Reflex sympathetic dystrophy].

We present a clinical report of an adolescent girl, referred for pain, cold temperature, pallor and functional disability of an inferior limb, all signals disclosed by a minor trauma. She had been diagnosed depression the year before. The bone scintigraphy was a decisive test. The treatment with gabapentin, C vitamin, physiotherapy and pshycotherapy has been effective. PMID: 22713207 [PubMed - in process] (Source: Acta Medica Portuguesa)

Postherpetic Neuralgia in Patients With Acute Herpes ZosterPostherpetic Neuralgia in Patients With Acute Herpes Zoster

What is the efficacy of combination treatment with gabapentin and valacyclovir for the prevention of postherpetic neuralgia in patients with acute herpes zoster? Medscape Dermatology (Source: Medscape Today Headlines)

Treatment of refractory trigeminal neuralgia with intravenous phenytoin.

Conclusion Phenytoin sodium 15 mg/kg i.v. divided into two doses separated by four hours was safe and effective in treating an acute exacerbation of refractory TN. PMID: 22011984 [PubMed - in process] (Source: American Journal of Health-System Pharmacy : AJHP)

Re: Bladder Pain Syndrome Treated With Triple Therapy With Gabapentin, Amitriptyline, and a Nonsteroidal Anti-Inflammatory Drug

J. W. Lee, D. Y. Han and H. J. Jeong Department of Urology and Institute of Wonkwang Medical Sciences, Wonkwang University School of Medicine, Iksan, Korea (Source: The Journal of Urology)<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>

Gabapentin: Anorgasmia: 4 case reports

(Source: Reactions)

Gabapentin/ketamine interaction: First report of an interaction, leading to prolonged CNS depression?: case report

(Source: Reactions)

[Epicrania fugax: the clinical characteristics of a series of 18 patients].

CONCLUSION. Our aim is to back the proposal of epicrania fugax as a new syndrome with a well-defined clinical spectrum. It does not appear to be an exceptional condition and further knowledge about it will probably give rise to the description of new series. Treatment is often necessary and, although further information and experience are needed, gabapentin and lamotrigine both play a promising role. PMID: 22012816 [PubMed - in process] (Source: Revista de Neurologia)

Lecture: profile of risks and benefits of new antiepileptic drugs in brain tumor-related epilepsy

Abstract&nbsp;&nbsp;In patients with brain tumor, seizures are the onset symptom in 20‚??40% of the patients, while a further 20‚??45% of the patients will present them during the course of the disease. These data are important when considering the choice of antiepileptic drugs for this particular patient population, because brain tumor-related epilepsy (BTRE) is often drug resistant, has a strong impact on the quality of life and weighs heavily on public health expenditures. In brain tumor patients, the presence of epilepsy is considered as the most important risk factor for long-term disability. For this reason, the problem of the proper administration of medications and their potential side effects is of great importance, because good seizure control can significantly improve the ...

Pain Relief in Laparoscopic Cholecystectomy‚??A Review of the Current Options

Abstract:‚?? Pain relief after laparoscopic cholecystectomy (LC) is an issue of great practical importance. Pain after LC has several origins: incisional, local visceral, peritoneal, and referred. Several modalities have been employed for achieving effective and safe analgesia: nonsteroidal anti‚?źinflammatory drugs (NSAIDs) and cyclooxygenase‚?ź2 (COX‚?ź2) inhibitors, gabapentinoids, local anesthetics, and transversus abdominis plane (TAP) block. They have their advantages and disadvantages, and multimodal approaches are often followed because of the multiple sources of pain. Among COX‚?ź2 inhibitors, parecoxib and valdecoxib are useful, and fears regarding their cardiovascular adverse effects in noncardiac surgery (such as LC) have not been substantiated when used in short term. Gabapent...<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>

Costs and Health Resources Utilization Following Switching to Pregabalin in Individuals with Gabapentin‚?źRefractory Neuropathic Pain: A post hoc Analysis

Conclusions:‚?? The cost of care in patients with gabapentin‚?źrefractory peripheral neuropathic pain appeared to be significantly reduced after switching to pregabalin treatment, alone or in combination with other analgesic drugs, in a real‚?źlife setting. (Source: Pain Practice)

Partial medial meniscectomy produces osteoarthritis pain-related behaviour in female C57BL/6 mice

Summary: Partial medial meniscectomy produces progressive degenerative joint disease and accompanying evoked pain behaviours in C57Bl/6 mice, providing a model for the study of osteoarthritic pain behaviours.Abstract: Murine models of osteoarthritis (OA) provide a potentially powerful tool to elucidate mechanisms responsible for OA pain. However, few studies have examined pain behaviours in relevant OA models in mice. We have therefore characterized the time course and pharmacological sensitivities of pain-related behaviours in a model of OA in C57Bl/6 mice induced by partial medial meniscectomy. Progressive degenerative joint damage developed in a time-dependent manner and was first detected 4weeks after surgery. Pain was assessed by monitoring weight bearing, mechanical hyperalgesia, col...

Costs and Health Resources Utilization Following Switching to Pregabalin in Individuals with Gabapentin‚?źRefractory Neuropathic Pain: A post hoc Analysis

Conclusions:‚?? The cost of care in patients with gabapentin‚?źrefractory peripheral neuropathic pain appeared to be significantly reduced after switching to pregabalin treatment, alone or in combination with other analgesic drugs, in a real‚?źlife setting. (Source: Pain Practice)

Depomed Announces Top-Line Results From Serada(R) Phase 3 Trial BREEZE 3 in Menopausal Hot Flashes

MENLO PARK, Calif., Oct. 13, 2011 (GLOBE NEWSWIRE) -- Depomed, Inc. (Nasdaq:DEPO) today announced top-line results from BREEZE 3, a Phase 3 trial evaluating the efficacy and safety of Serada(r) (extended-release gabapentin tablets) for menopausal hot flashes. Serada is a proprietary formulation of gabapentin using patented polymer technology that enables gradual release of the drug. (Source: Medical News (via PRIMEZONE))<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>

Comparison of two aerosol-based detectors for the analysis of gabapentin in pharmaceutical formulations by hydrophilic interaction chromatography.

Authors: Jia S, Park JH, Lee J, Kwon SW Abstract Comparison of hydrophilic interaction chromatography (HILIC) columns coupled with an evaporative light scattering detector (ELSD) or charged aerosol detector (CAD) was done for the detection of gabapentin in pharmaceutical formulations. The chromatographic separations were achieved on four HILIC columns: ZIC HILIC, ZIC pHILIC, Luna HILIC, and Atlantis HILIC. Experimental factors such as mobile phase composition, acetonitrile content, and mobile phase pH were evaluated. Validation of method was done in terms of linearity, sensitivity, accuracy, and precision. The performance of ELSD detection method is comparable to that of CAD. The intra-day and inter-day variations were below 1.7% and 3.2% for CAD and 2.8%, and 3.4% for ELSD, respec...

[Articles] Comparative efficacy and acceptability of antimanic drugs in acute mania: a multiple-treatments meta-analysis

SummaryBackgroundConventional meta-analyses have shown inconsistent results for efficacy of pharmacological treatments for acute mania. We did a multiple-treatments meta-analysis, which accounted for both direct and indirect comparisons, to assess the effects of all antimanic drugs.MethodsWe systematically reviewed 68 randomised controlled trials (16‚??073 participants) from Jan 1, 1980, to Nov 25, 2010, which compared any of the following pharmacological drugs at therapeutic dose range for the treatment of acute mania in adults: aripiprazole, asenapine, carbamazepine, valproate, gabapentin, haloperidol, lamotrigine, lithium, olanzapine, quetiapine, risperidone, topiramate, and ziprasidone. (Source: LANCET)

Retention rate of Gabapentin in children with intractable epilepsies at 1 year

Abstract: Gabapentin (GAB) is a newer second-line antiepileptic drug (AED) used in children. This is a multi-centre retrospective observational study of the efficacy, tolerability and retention rate in 105 children, aged 0‚??17.5 years (mean 10.1) over a 14 year period.The median age of epilepsy onset was 2.5 years (range 0‚??14.6). 72% started GAB as at least the 3rd AED, with 43% having been withdrawn from at least 2 AEDs. 77% had focal and 52% symptomatic epilepsies. The maintenance doses for GAB ranged 6.0‚??87.3mg/kg/day (mean 43.7). The study comprised 157 person-treatment years for GAB.GAB was well tolerated with 55% remaining on treatment beyond 1 year. No serious adverse events were reported whilst on GAB, but 39% reported possibly and probably related adverse events. Seizure impr...

A prospective study on the role of gabapentin in post-burn pruritus

Abstract&nbsp;&nbsp;Gabapentin, used in the treatment of neuropathic pain, is suggested as an alternative treatment to antihistamines for post-burn itching. There is insufficient awareness about the etiopathogenesis and available treatment options for post-burn pruritus. To study the effect of gabapentin on post-burn itching, patients with post-burn pruritus not relieved with cetirizine tablet were offered gabapentin and assessed for response by the numerically graded self-report questionnaire ‚??Itch Severity Scale‚?? for 6&nbsp;months. Treatment success was determined by reduction in the itch scores, which were statistically analysed. Twenty-three patients with post-burns pruritic hypertrophic scars were studied. All patients had history of delayed burn healing (over 3&nbsp;weeks)....

Errata

Zand L, McKian KP, Qian Q. Gabapentin Toxicity in Patients with Chronic Kidney Disease: A Preventable Cause of Morbidity. Am J Med. 2010;123:367-373. The unit for eGFR in this paper should be mL/min/1.72 mm2 and not mL/min/1.72 mm3 or mL/min/1.73 mm3 This correction should be applied a total of 8 times: twice in the Methods section of the abstract; twice on page 368, column 2, first paragraph; on page 368 in Table 1; on page 370 in Tables 2 and 3; and on page 371 in Table 4. (Source: The American Journal of Medicine)<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>

Successful treatment of tabetic lightning pain and visceral crisis with gabapentin

Content Type Journal ArticleCategory Letter to the EditorPages 1-1DOI 10.1007/s00540-011-1219-zAuthors Kyoko Oshita, Department of Anesthesiology and Critical Care, Hiroshima University Hospital, Hiroshima University, 1-2-3 Kasumi, Minami-ku, Hiroshima, 734-8551 JapanNoboru Saeki, Department of Anesthesiology and Critical Care, Hiroshima University Hospital, Hiroshima University, 1-2-3 Kasumi, Minami-ku, Hiroshima, 734-8551 JapanHiroshi Niinai, Department of Anesthesiology and Critical Care, Hiroshima University Hospital, Hiroshima University, 1-2-3 Kasumi, Minami-ku, Hiroshima, 734-8551 JapanHiroshi Hamada, Department of Anesthesiology and Critical Care, Hiroshima University Hospital, Hiroshima University, 1-2-3 Kasumi, Minami-ku, Hiroshima, 734-8551 JapanMasashi Kawamoto, Department ...

GABAPENTIN (Gabapentin) Capsule [Unit Dose Services]

Updated Date: Sep 27, 2011 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

Few Patients With Neuralgia Receive Optimal Gabapentin DoseFew Patients With Neuralgia Receive Optimal Gabapentin Dose

Very few patients with postherpetic neuralgia actually achieve the optimal recommended dose of gabapentin, new research shows. Medscape Medical News (Source: Medscape Today Headlines)

Quiz Page October 2011: An Under-recognized Cause of CKD

A 47-year-old woman was evaluated for decreasing kidney function. In 2008, serum creatinine level was 0.89 mg/dL (79 őľmol/L; estimated glomerular filtration rate [eGFR] >60 mL/min/1.73 m2 [>1 mL/s/1.73 m2], calculated using the 4-variable MDRD [Modification of Diet in Renal Disease] Study equation) and had been stable for 5 years. In 2009, it increased to 1.26 mg/dL (111 őľmol/L; eGFR, 49 mL/min/1.73 m2 [0.82 mL/s/1.73 m]), 1.62 mg/dL (143 őľmol/L; eGFR, 37 mL/min/1.73 m2 [0.62 mL/s/1.73 m]), and then 2.15 mg/dL (190 őľmol/L; eGFR, 26 mL/min/1.73 m2 [0.43 mL/s/1.73 m]) by March 2010. Medical history included anorexia nervosa, deliberate self-harm, left hip fracture, and chronic pain syndrome. Prescribed medications were gabapentin, naproxen, ranitidine, cyclizine, and acetaminophen. (Sour...

Nurofen tampering charge: accused remanded in custody

Christopher McGuire charged with contaminating Nurofen Plus painkillers with anti-psychotic drugsA man has been remanded in custody accused of contaminating packs of Nurofen Plus painkillers with anti-psychotic and anti-epileptic drugs.Christopher McGuire, 30, of no fixed address, appeared in a brief hearing at west London magistrates court. He spoke only to confirm his name and date of birth.McGuire is charged with four counts of contamination of goods, and two counts of administering a noxious substance. The maximum sentence if convicted is 10 years in jail.He was remanded by District Judge John Zani to appear at Southwark crown court on 2 December for a plea and case management hearing.Reckitt Benckiser, manufacturer of the drug, recalled the product on 26 August and halted distribution...<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>

Predictors of Duloxetine versus Other Treatments among Veterans with Diabetic Peripheral Neuropathic Pain: A Retrospective Study

Conclusion:‚?? DPNP patients in the VA healthcare system with prior other treatment use, select comorbid conditions, prior substance abuse, prior opioid use, and higher pain level were more likely to receive duloxetine. (Source: Pain Practice)

Interactions of pregabalin with gabapentin, levetiracetam, tiagabine and vigabatrin in the mouse maximal electroshock-induced seizure model: A type II isobolographic analysis

Summary: The aim of this study was to characterize the anticonvulsant effects of pregabalin in combination with four second-generation antiepileptic drugs (i.e., gabapentin, levetiracetam, tiagabine, and vigabatrin) in the mouse maximal electroshock (MES)-induced seizure model by using the type II isobolographic analysis.Tonic hind limb extension (seizure activity) was evoked in adult male albino Swiss mice by a current (sine-wave, 25mA, 500V, 50Hz, 0.2s stimulus duration) delivered via auricular electrodes.The combination of pregabalin with gabapentin at the fixed-ratio of 1:1 was supra-additive (synergistic) in terms of seizure suppression while the combinations at the fixed-ratios of 2:1 and 4:1 were additive in the mouse MES model. Similarly, the combination of pregabalin with tiagabin...

Predictors of Duloxetine versus Other Treatments among Veterans with Diabetic Peripheral Neuropathic Pain: A Retrospective Study

Conclusion:‚?? DPNP patients in the VA healthcare system with prior other treatment use, select comorbid conditions, prior substance abuse, prior opioid use, and higher pain level were more likely to receive duloxetine. (Source: Pain Practice)

Nurofen contamination: man charged

Christopher McGuire charged after antipyschotic and antiepileptic drugs found in five packs of painkillerA man has been charged with contaminating packs of Nurofen Plus which were found to contain antipsychotic and antiepileptic drugs, police have said. Christopher McGuire, 30, of no fixed abode, was arrested on Friday and charged on Saturday night with one count of contamination of goods, and two counts of administering a noxious substance. Reckitt Benckiser, manufacturer of the drug, recalled the product on 26 August and halted distribution after discovering that five boxes contained other companies' medicines. It estimated that 250,000 packets were still in customers' hands.Four of the affected boxes were found to contain the anti-psychotic drug Seroquel XL 50mg and one packet contained...

Off-label gabapentin masking ictal triphasic waves: Case analysis of neuropsychiatric and electrographic correlates.

We report a case of off-label gabapentin use masking ictal electrographic activity, the neuropsychiatric and electrographic consequences of discontinuing gabapentin, and the therapeutic response when gabapentin was re-initiated and titrated to a total daily dose greater than that at time of admission. Weaning from AEDs with concurrent video/EEG monitoring is an important diagnostic tool in these complex cases. PMID: 21945412 [PubMed - as supplied by publisher] (Source: Epilepsy and Behaviour)<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>

Gabapentin for Tinnitus: A Systematic Review.

CONCLUSION: The authors of the both studies reported that gabapentin was not superior to placebo in their primary outcomes. However, following the assessment of risk of bias, and within-study clinical heterogeneities, this review concludes that there is insufficient evidence regarding the effect of gabapentin on tinnitus. PMID: 21940981 [PubMed - as supplied by publisher] (Source: American Journal of Audiology)

Gabapentin withdrawal: Akathisia in an elderly patient: case report

(Source: Reactions)

NEURONTIN (Gabapentin) Capsule NEURONTIN (Gabapentin) Tablet, Film Coated NEURONTIN (Gabapentin) Solution [Parke-Davis Div Of Pfizer Inc]

Updated Date: Sep 16, 2011 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

Comparison of the efficacy of carbamazepine, gabapentin and lamotrigine for neuropathic pain in rats

Conclusions : In paclitaxel induced neuropathic pain, lamotrigine appears to be a promising drug. The difference in responses shown by different antiepileptics&#x0027; depends on the etiology of the underlying mechanisms in neuropathic pain. (Source: Indian Journal of Pharmacology)

Erratum to: The Stabilizing Effect of Moisture on the Solid-State Degradation of Gabapentin.

Authors: Zong Z, Desai SD, Kaushal AM, Barich DH, Huang HS, Munson EJ, Suryanarayanan R, Kirsch LE PMID: 21918917 [PubMed - as supplied by publisher] (Source: AAPS PharmSciTech)<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>

Review of Current Guidelines on the Care of Postherpetic Neuralgia

Charles E. Argoff, MD DOI: 10.3810/pgm.2011.09.2469 Abstract: An unfortunate minority of patients with acute herpes zoster (AHZ) experience pain beyond the typical 4-week duration, and roughly 10&#x00025; develop the distressing complication of postherpetic neuralgia (PHN), often defined as pain persisting for &#x0003E; 4 months after the onset of the rash. Elderly patients are at increased risk of PHN. The pathophysiology of PHN is complex, likely involving both peripheral and central processes. This complexity may create opportunities for pharmacologic interventions with multiple differing mechanisms of action. Consequently, complementary combinations of pharmacologic agents are frequently more effective than any monotherapy. Current US and international guidelines on the care of p...

P3.14 Drug treatment in spinal muscular atrophy types 1, 2 and 3: An update of the systematic Cochrane review

Spinal muscular atrophy (SMA) is characterized by proximal weakness caused by loss of motor neurons in the anterior horn and homozygous deletion of the SMN1 gene. SMA is classified according to age of onset and acquired motor milestones. Treatment of SMA is supportive as there is no known efficacious drug treatment. Using Cochrane methodology, we systematically evaluated all randomized controlled trials on the efficacy of drug treatment to slow or arrest disease progression of SMA types 1‚??3. Of 22 eligible studies, 7 trials fulfilled the selection criteria. One underpowered trial that included 10 patients with SMA type 1 showed no effect of riluzole treatment on survival and mortality. Efficacy of treatment for SMA types 2/3 was evaluated in 6 trials. A trial with negative results invest...

NICE proposes changes to first-line treatment recommendations for neuropathic pain

Source: NICE Area: News NICE is consulting on proposed changes to some of the recommendations made in its clinical guideline on the pharmacological management of neuropathic pain in adults in non-specialist settings (CG 96; March 2010).&nbsp; This action follows concerns about the associated costs that pregabalin may bring to the NHS as one of the first line treatment options for adults with neuropathic pain, and considers new evidence regarding the first-line treatment options.&nbsp; &nbsp; The draft guideline containing amended recommendations is now available for consultation; registered stakeholders are invited to make comments on the provisional recommendations via the website (the consultation closes at 9am on 10th October 2011). &nbsp; The main recommendations regarding fir...

Pharmacological and behavioral characterization of the saphenous chronic constriction injury model of neuropathic pain in rats

Abstract&nbsp;&nbsp;The aim of the present study was to develop a new experimental pain model by adapting the chronic constriction injury (CCI) model of the sciatic nerve to the exclusively sensory saphenous nerve in rats. Animals were divided into na√Įve, sham, and two experimental groups, in which two or four 4-0 chromic gut ligatures were loosely ligated around the saphenous nerve. Then, behavioral signs of neuropathic pain were observed for 8&nbsp;weeks. In rats with four ligatures, prominent mechanical allodynia and thermal hyperalgesia developed; these behavioral signs were not prominent in rats with two ligatures. Pharmacological analysis was made in rats with four loose ligations; morphine and WIN 55,212-2, a cannabinoid agonist, reversed all of the modalities tested, whereas...<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>

Successful Amelioration of Tinnitus in a Stroke Patient by Low-dose Gabapentin

Bilaterally progressive tinnitus and hearing impairment occurred in a hypertensive patient shortly after an episode of right ganglionic hemorrhage. Audiometric tests showed a mixed sensorineural and conduction hearing loss. When low-dose gabapentin was administrated for the pre-existing postherpetic thoracic neuralgia, the tinnitus dramatically improved but recurred after discontinuation of the drug. Hearing function did not change. In view of a controversy of gabapentin and tinnitus in previous trials, the findings in this patient support that low-dose gabapentin benefits the subgroup of tinnitus patients with secondary contributing factors, such as stroke. (Source: Journal of Stroke and Cerebrovascular Diseases)

Predictors of Pain Medication Selection Among Patients Diagnosed with Fibromyalgia

Conclusions:‚?? The presence of select comorbidities and prior use of certain medications were associated with the duloxetine initiation among working‚?źage, commercially insured patients with fibromyalgia. (Source: Pain Practice)

Table of Contents

AbstractNo Clinical Advantage of Combination Antidepressant Treatment Over MonotherapyPrenatal SSRI Exposure Unlikely to Be Major Risk Factor for AutismAripiprazole and Restless Legs SyndromeSwitching from Antipsychotic Polypharmacy to MonotherapyPregabalin Possibly Useful for Social Anxiety DisorderShort‚?źTerm Benefits of Add‚?źOn Gabapentin with NaltrexoneAtypical Antipsychotics for Posttraumatic StressVarenicline for Smokers and Cardiovascular RiskFluvoxamine and Long QTU SyndromeJuly 2011 ApprovalsNew Warnings (Source: The Brown University Psychopharmacology Update)

Diabetic peripheral neuropathic pain: is gabapentin effective?

Authors: Hyatt JD, Daniel D, Tran QV, Millares M, Kubota DR PMID: 21888297 [PubMed - in process] (Source: American Family Physician)

Pharmacological tests of hypotheses for acquired pendular nystagmus

Acquired pendular nystagmus (APN) occurs with multiple sclerosis (MS) and oculopalatal tremor (OPT); distinct features of the nystagmus have led to the development of separate models for their pathogenesis. APN in MS has been attributed to instability in the neural integrator, which normally ensures steady gaze. APN in OPT may result from electrotonic coupling between neurons in the hypertrophied inferior olivary nucleus, which induces maladaptive learning in cerebellar cortex. We tested these two hypotheses by analyzing the effects of gabapentin, memantine, and baclofen on both forms of nystagmus. No drug changed the dominant frequency of either form of APN, but the variability of frequency was affected with gabapentin and memantine in patients with OPT. The amplitude of APN in both MS an...<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>

T215 effect of gabapentin on neuropathic pain in failed back surgery syndrome

(Source: European Journal of Pain Supplements)

T234 evaluation of cr, in comparison with gabapentin and amitriptyline, in a rat model of fibromyalgia

(Source: European Journal of Pain Supplements)

T270 effect of pregabalin on cost and clinical consequences in gabapentin-refractory patients with peripheral neuropathic pain in primary care settings

(Source: European Journal of Pain Supplements)

F519 effect of pregabalin on patient-reported outcomes in gabapentin-refractory patients with neuropathic pain: findings from a non-interventional trial in real-world settings

(Source: European Journal of Pain Supplements)

F625 does long-term administration of gabapentin or paroxetine reduce neuropathic pain in a rodent model? ‚?? a placebo controlled study

(Source: European Journal of Pain Supplements)<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>

F638 a nitric oxide (no)-donating gabapentin, ncx 1236, reverses the development of mechanical allodynia in streptozotocin-treated diabetic mice

(Source: European Journal of Pain Supplements)

S189 long term treatment with gabapentin in an animal model of central neuropathic pain

(Source: European Journal of Pain Supplements)

S258 gabapentin vs. pregabalin for the treatment of neuropathic pain in patients with spinal cord injury: a cross-over study

(Source: European Journal of Pain Supplements)

S265 randomized, double-blinded, placebo-controlled study evaluating the efficacy and safety of nabilone adjunctive to gabapentin in managing multiple sclerosis-induced neuropathic pain

(Source: European Journal of Pain Supplements)

S623 effect of pregabalin on reduction of concomitant pharmacological and non-pharmacological analgesic treatments use in gabapentin-refractory patients with peripheral neuropathic pain

(Source: European Journal of Pain Supplements)<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>

Cost analysis of adding pregabalin or gabapentin to the management of community‚?źtreated patients with peripheral neuropathic pain

Conclusions‚?? In community‚?źtreated patients with PNP, total costs were considerably less for those patients initiated with pregabalin therapy than for those patients starting gabapentin add‚?źon therapy. The relatively higher treatment acquisition cost of pregabalin was largely compensated by the overall lower costs for the other components of health care resources and sick leave, thus reducing the economic impact on the health care provider's budget and society. (Source: Journal of Evaluation in Clinical Practice)

Nurofen Plus recalled as drug manufacturer suspects sabotage

Reckitt Benckiser recalls about 250,000 packs of painkiller amid police investigationAbout 250,000 packs of Nurofen Plus are being recalled amid a police investigation into suspected sabotage when the wrong drug was found in some packs.A spokesman for Reckitt Benckiser (UK) Ltd, manufacturer of the Nurofen painkiller, said there had been five reported cases of other manufacturers' medicines discovered in boxes of Nurofen Plus.The alert was raised after the anti-psychotic prescription drug Seroquel XL, made by another manufacturer, AstraZeneca UK, was found in packs that should have contained painkillers. The drug is used to treat disorders including schizophrenia, mania and bipolar depression.Neurontin, an epilepsy drug made by a third company, Pfizer, was also been found in another batch....

NEURONTIN (Gabapentin) Capsule NEURONTIN (Gabapentin) Tablet, Film Coated NEURONTIN (Gabapentin) Solution [Parke-Davis Div Of Pfizer Inc]

Updated Date: Aug 26, 2011 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

Intrathecal Morphine Pump for Neuropathic Cancer Pain: A Case Report.

We report a case of a 61 year old female patient with endometrial carcinoma suffering from severe neuropathic pain in her left lower limb. The pain was refractory to highest tolerable doses of oral morphine and neuromodulator drugs, viz. gabapentin and pregabalin. We managed the patient successfully with intrathecal morphine pump reducing the total morphine dose and improving patient comfort and satisfaction. Intrathecal delivery of Morphine ensured better efficacy with fewer side effects. PMID: 21868426 [PubMed - as supplied by publisher] (Source: The American Journal of Hospice and Palliative Care)<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>

The long-term retention of zonisamide in a large cohort of people with epilepsy at a tertiary referral centre

Summary: Zonisamide (ZNS) is an antiepileptic drug (AED) with multiple putative mechanisms of action. It is chemically unrelated to other AEDs. It has been available in Japan since 1989 but was only licensed in Europe in 2005. Its efficacy and tolerability have been shown in several randomised controlled trials, but large studies on long-term performance in Western clinical practice are scarce.We assessed a large cohort of consecutive people who started ZNS at a tertiary epilepsy referral centre, from June 2005 to July 2009.Forty-six percent of the 417 people included were still taking ZNS at last follow-up, with an estimated retention rate at three years of 30%. Almost one third of the population reported a period of improvement in terms of seizure reduction of at least six months duratio...

Trends in the use of antiepileptic drugs in Taiwan from 2003 to 2007: A Population-Based National Health Insurance study

Conclusion: An increase in the use of AEDs was observed over a 5-year period in data collected from NHIRD. This might implicate the use of newer compounds at clinical practice not only increased in the treatment of epilepsy, but also in the conditions other than epilepsy especially pain disorders. (Source: Epilepsy Research)

Evaluation of Anticonvulsants for Possible Use in Neuropathic Pain.

Authors: Waszkielewicz AM, Gunia A, SŇ?oczyŇ?ska K, Marona H Abstract Neuropathic pain is a kind of pain related with functional abnormality of neurons. Despite large progress in pharmacotherapy, neuropathic pain is still considered an unmet need. Nowadays, there are few drugs registered for this condition, such as pregabalin, gabapentin, duloxetine, carbamazepine, and lidocaine. Among them, pregabalin, gabapentin and carbamazepine are well known antiepileptic drugs.Among the group of new antiepileptic drugs, which are addressed to 1% of human world population suffering from seizures, it turned out that 30% of the seizures resistant to pharmacotherapy has not enough market to justify the costs of drug development. Therefore, it is already a phenomenon that researchers turn their pr...

Drug therapy for treating post-dural puncture headache.

CONCLUSIONS: Caffeine has shown effectiveness for treating PDPH, decreasing the proportion of participants with PDPH persistence and those requiring supplementary interventions, when compared with placebo. Gabapentin, theophylline and hydrocortisone have also shown a decrease in pain severity scores when compared with placebo or conventional care.There is a lack of conclusive evidence for the other drugs assessed (sumatriptan and ACTH).These conclusions should be interpreted with caution, due to the lack of information to allow correct appraisal of risk of bias, the small sample sizes of studies and also the limited generalisability, as most participants were post-partum women in their 30s. PMID: 21833962 [PubMed - in process] (Source: Cochrane Database of Systematic Reviews)

Menopausal hot flushes and night sweats: where are we now?

Conclusions Vasomotor symptoms are experienced by women of all ethnic groups. They are caused by changes in the central nervous system associated with estrogen withdrawal and are best treated with estrogen replacement therapy. Objective monitoring of hot flushes indicates that placebo has little to no effect on their improvement. Subjective assessments of hot flushes in clinical trials may be inaccurate based on objective measurement of the frequency of hot flushes. Based on preliminary reports, women experiencing hot flushes have an increased risk of cardiovascular disease and a reduced incidence of breast cancer. PMID: 21848495 [PubMed - as supplied by publisher] (Source: Climacteric)<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>

Pharmacological Treatment of Insomnia in Alcohol Recovery: A Systematic Review

Conclusion: Trazodone has the most data suggesting efficacy. This finding is tempered by a study suggesting its association with a return to heavy drinking in some patients. Data regarding the efficacy of gabapentin are unclear at this point. (Source: Alcohol and Alcoholism)

THERAPENTIN-90 (Gabapentin, .Gamma.-Aminobutyric Acid) Kit [Physician Therapeutics LLC]

Updated Date: Aug 15, 2011 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

Incidence of Postherpetic Neuralgia After Combination Treatment With Gabapentin and Valacyclovir in Patients With Acute Herpes Zoster: Open-label Study [Study]

Conclusion&nbsp; The combination of gabapentin and valacyclovir administered acutely in patients with herpes zoster reduces the incidence of postherpetic neuralgia. Trial Registration&nbsp; clinicaltrials.gov Identifier: NCT01250561. (Source: Archives of Dermatology)

Prevent Rather Than Treat Postherpetic Neuralgia by Prescribing Gabapentin Earlier in Patients With Herpes Zoster: Comment on "Incidence of Postherpetic Neuralgia After Combination Treatment With Gabapentin and Valacyclovir in Patients With Acute Herpes Zoster" [Practice Gaps]

(Source: Archives of Dermatology)

THERAPENTIN-60 (Gabapentin, .Gamma.-Aminobutyric Acid) Kit [Physician Therapeutics LLC ]

Updated Date: Aug 12, 2011 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>

Gabapentin as part of multi‚?źmodal analgesia in two cats suffering multiple injuries

(Source: Veterinary Anaesthesia and Analgesia)

Horizon scanning: Supplemental New Drug Application for Horizant in postherpetic neuralgia submitted to the FDA

Source: PharmaLive Area: News According to PharmaLive, a supplemental New Drug Application has been submitted to the US FDA requesting approval of gabapentin enacarbil (HorizantT) extended-release tablets for the management of postherpetic neuralgia in adults. (Source: NeLM - News)

Regulatory Update: GSK and XenoPort submit supplemental New Drug Application to FDA for Horizant‚?Ę in postherpetic neuralgia

GlaxoSmithKline (NYSE and LSE: GSK) and XenoPort, Inc. (Nasdaq: XNPT) announced today that a supplemental New Drug Application (sNDA) has been submitted to the U.S. Food and Drug Administration (FDA) requesting approval of Horizant‚?Ę (gabapentin enacarbil) Extended-Release Tablets for the management of postherpetic neuralgia (PHN) in adults. ¬†The sNDA has been submitted to the FDA by GSK. (Source: GSK news)

A Randomized, Double-Blind, Placebo-Controlled Study to Assess the Efficacy and Tolerability of Gabapentin Enacarbil in Subjects with Restless Legs Syndrome

Conclusions: GEn 1200 mg and 600 mg significantly improve RLS symptoms and sleep disturbance compared with placebo and are generally well tolerated. Keywords: Gabapentin enacarbil, PIVOT RLS II, restless legs syndrome, GSK1838262, XP13512 (Source: Journal of Clinical Sleep Medicine : JCSM)

Preliminary Assessment of a Neuropathic Pain Treatment and Referral Algorithm for Patients With Cancer

Abstract: Context: The purpose of this case series study was to pilot test an evidence-based neuropathic pain (NP) treatment and referral algorithm for use by oncology nurses when managing cancer-related NP.Objectives: The primary study objective was to assess patient-reported outcomes (pain severity, changes in activities of daily living, and satisfaction) resulting from algorithm use.Methods: Outpatients (n=20) with cancer-related NP scores ‚?•4 on a 0‚??10 numeric rating scale participated in the study. NP assessment, treatment, and referral to ancillary providers were guided by an evidence-based NP algorithm that was implemented by oncology nurse practitioners. Based on efficacy evidenced through randomized clinical trials published at the time of study implementation, the following dr...<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>

Effects of gabapentin on postoperative pain, nausea and vomiting after abdominal hysterectomy: a double blind randomized clinical trial

Conclusion&nbsp;&nbsp;Pre-emptive use of gabapentin 600&nbsp;mg orally, significantly decreases postoperative pain and PONV, and also rescues analgesic and anti emetic drug requirements in patients who undergo abdominal hysterectomy. Content Type Journal ArticlePages 1-6DOI 10.1007/s00404-011-2023-6Authors Ladan Ajori, Department of Obstetrics and Gynecology, Shahid Beheshti University of Medical Science, Tehran, IranLeila Nazari, Department of Obstetrics and Gynecology, Shahid Beheshti University of Medical Science, Tehran, IranMohammad Mohsen Mazloomfard, Department of Obstetrics and Gynecology, Shahid Beheshti University of Medical Science, Tehran, IranZohreh Amiri, Department of Obstetrics and Gynecology, Shahid Beheshti University of Medical Science, Tehran, Iran Jo...

Scientists credited on ghostwritten articles 'should be charged with fraud'

This article was amended on 3 August 2011 to give the correct spelling of Trudo LemmensPeer review and scientific publishingDrugsMedical researchHealthEthicsPharmaceuticals industryIan Sampleguardian.co.uk &copy; Guardian News & Media Limited 2011 | Use of this content is subject to our Terms & Conditions | More Feeds (Source: Guardian Unlimited Science)

Perioperative administration of gabapentin for shoulder arthroscopy: a prospective, randomized, double-blind, placebo-controlled study.

Authors: Spence D, Goff J, Mohan E, Bowen K, Osborne L, Maye J Abstract Recent studies suggest gabapentin has opioid-sparing effects and may reduce acute postoperative pain. However, there is limited research on the efficacy of gabapentin when combined in a multimodal approach after shoulder arthroscopy under general anesthesia with an interscalene block. We conducted prospective, double-blind study of 70 patients who were randomized to receive either 300 mg of gabapentin or placebo 1 hour before surgery, then twice a day for 2 days. The primary outcome was average pain scores. Secondary outcomes included differences in morphine equivalents, adverse effects, and sleep patterns. No significant differences in pain scores were found on day 1 (gabapentin mean [SD], 4.23 [2.61], vs plac...

GABAPENTIN (Gabapentin) Capsule [PD-Rx Pharmaceuticals, Inc.]

Updated Date: Jul 29, 2011 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

NICE issues guidance on use of retigabine for the adjunctive treatment of adults with partial onset seizures in epilepsy with and without secondary generalisation (TA 232)

Source: NICE Area: Evidence > Guidelines The National Institute for Health and Clinical Excellence (NICE) has issued guidance on the use of retigabine for the adjunctive treatment of partial onset seizures with or without secondary generalisation in adults aged 18 years and older with epilepsy.&nbsp; &nbsp; NICE recommends that retigabine is an option for the adjunctive treatment of partial onset seizures with or without secondary generalisation in adults aged 18 years and older with epilepsy, only when previous treatment with carbamazepine, clobazam, gabapentin, lamotrigine, levetiracetam, oxcarbazepine, sodium valproate and topiramate has not provided an adequate response, or has not been tolerated. &nbsp; Please see link for details. (Source: NeLM - Guidelines)<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>

GABAPENTIN (Gabapentin) Tablet, Film Coated [PD-Rx Pharmaceuticals, Inc.]

Updated Date: Jul 26, 2011 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

A Comparative Efficacy of Amitriptyline, Gabapentin, and Pregabalin in Neuropathic Cancer Pain: A Prospective Randomized Double-Blind Placebo-Controlled Study

Am J Hosp Palliat Care (new issue) (Source: Palliative Care JournalClub - Selected Articles)

Neurontin and Gabarone: Effective treatment for fibromyalgia?

Fibromyalgia treatment &mdash; Gabapentin may be effective, but studies are limited. (Source: MayoClinic.com Full Feed)

Review: Gabapentin reduces some types of chronic neuropathic pain more than placebo in adults.

Authors: PMID: 21768574 [PubMed - in process] (Source: Annals of Internal Medicine)<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>

GRALISE (Gabapentin) Tablet, Film Coated GRALISE (Gabapentin) Kit [Depomed, Inc.]

Updated Date: Jul 18, 2011 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

Gabapentin: Myoclonus in an elderly patient: case report

(Source: Reactions)

High-volume infiltration analgesia in bilateral hip arthroplasty.

Authors: Andersen L, Otte KS, Husted H, Gaarn-Larsen L, Kristensen B, Kehlet H Background and purpose High-volume infiltration analgesia may be effective in postoperative pain management after hip arthroplasty but methodological problems prevent exact interpretation of previous studies. Methods In a randomized, double-blind placebo-controlled trial in 12 patients undergoing bilateral total hip arthroplasty (THA) in a fast-track setting, saline or high-volume (170 mL) ropivacaine (0.2%) with epinephrine (1:100,000) was administered to the wound intraoperatively along with supplementary postoperative injections via an intraarticular epidural catheter. Oral analgesia was instituted preoperatively with a multimodal regimen (gabapentin, celecoxib, and acetaminophen). Pain was assessed repea...

Pharmacotherapy of fibromyalgia.

Conclusion A broad range of drugs has been used to treat fibromyalgia. Symptoms, comorbidities, adverse effects, and patient preference are important considerations in drug selection. PMID: 21719591 [PubMed - in process] (Source: American Journal of Health-System Pharmacy : AJHP)

Gabapentin May Help Treat Alcohol DependenceGabapentin May Help Treat Alcohol Dependence

Gabapentin added to naltrexone helped heavy drinkers stay off the booze for a longer period of time in this prospective, randomized trial. Medscape Medical News (Source: Medscape Today Headlines)<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>

GABAPENTIN (Gabapentin) Tablet [REMEDYREPACK INC. ]

Updated Date: Jul 11, 2011 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

A Comparative Efficacy of Amitriptyline, Gabapentin, and Pregabalin in Neuropathic Cancer Pain: A Prospective Randomized Double-Blind Placebo-Controlled Study.

Authors: Mishra S, Bhatnagar S, Nirvani Goyal G, Pratap Singh Rana S, Upadhya SP Neuropathic pain is difficult to diagnose and difficult to treat with certainty. So the aim of the study was to evaluate comparative clinical efficacy of pregabaline with amitriptyline and gabapentin in neuropathic cancer pain. A total of 120 patients with cancer having severe neuropathic cancer pain were enrolled in the study after taking approval from Institutional Ethics Committee and divided in to 4 groups: group AT-amitriptyline, group GB-gabapentin, group PG-pregabalin, and group PL-placebo. Oral morphine was used for rescue analgesic for continued pain. Pain score (Visual Analogue scale) and secondary outcome measures such as intensity of lancinating, dysesthesia, and burning on numerical rating sca...

The Stabilizing Effect of Moisture on the Solid-State Degradation of Gabapentin.

Authors: Zong Z, Desai SD, Kaushal AM, Barich DH, Huang HS, Munson EJ, Suryanarayanan R, Kirsch LE Gabapentin is known to undergo intramolecular cyclization to form a lactam (gaba-L: ) with concomitant loss of water. Gabapentin was milled in a planetary mill for 15-60¬†min. Unmilled and milled gabapentin were stored at 50¬įC with relative humidity ranged between 5% and 90%. The unmilled and milled samples were assayed for gabapentin and gaba-L: by reversed phase-high-performance liquid chromatography and also subjected to powder X-ray diffraction, solid-state nuclear magnetic resonance and surface area analyses. The rates of lactamization in the milled gabapentin samples correlated to increased surface area, milling duration, and in-process lactam levels. This effect of milling could n...

The true purpose of a drug trial is not always obvious | Ben Goldacre

Medical trials are not always conducted to test the drug ‚?? sometimes it's to test the marketHere's a fun new way to distort science from the pages of Annals of Internal Medicine this week. Let's imagine you want to know if your new epilepsy drug, already shown to be effective with strict trials in rarefied ideal patients, also works in routine clinical use. Epilepsy is common. The obvious, practical option is to choose a few centres as research clinics, and recruit from those. That will keep costs down, you can train participating doctors more easily and you can monitor data standards properly. You'll get good data and a reliable answer.The Steps (Study of Neurontin: Titrate to Effect, Profile of Safety) trial on gabapentin was different. Instead of recruiting lots of patients through a ...

The charade of 'seeding' drug trials

This article was amended on 2 July 2011. The original stated that the analysis was in the Annals of Internal Medicine. This has been corrected.DrugsMedical researchBen Goldacreguardian.co.uk &copy; Guardian News & Media Limited 2011 | Use of this content is subject to our Terms & Conditions | More Feeds (Source: Guardian Unlimited Science)<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>

Predictors of Pain Medication Selection Among Patients Diagnosed with Fibromyalgia

Conclusions:‚?? The presence of select comorbidities and prior use of certain medications were associated with the duloxetine initiation among working‚?źage, commercially insured patients with fibromyalgia. (Source: Pain Practice)

Gabapentin for complex regional pain syndrome in Machado-Joseph disease: a case report

Conclusions: The pathophysiology of complex regional pain syndrome includes peripheral and central sensitizations, the latter of which might be associated with the neurodegeneration in Machado-Joseph disease. In this report, we suggest that gabapentin could inhibit central sensitization as an adjunct for complex regional pain syndrome in patients with Machado-Joseph disease. (Source: BioMed Central)

Gabapentin Combined With Naltrexone for the Treatment of Alcohol Dependence [Articles]

Conclusions: The addition of gabapentin to naltrexone improved drinking outcomes over naltrexone alone during the first 6 weeks after cessation of drinking. This effect did not endure after gabapentin was discontinued. (Source: Am J Psychiatry)

Spatiotemporal specificity of GABAA receptor‚?źmediated regulation of adult hippocampal neurogenesis

AbstractGABAergic transmission regulates adult neurogenesis by exerting negative feedback on cell proliferation and enabling dendrite formation and outgrowth. Further, GABAergic synapses target differentiating dentate gyrus granule cells prior to formation of glutamatergic connections. GABAA receptors (GABAARs) mediating tonic (extrasynaptic) and phasic (synaptic) transmission are molecularly and functionally distinct, but their specific role in regulating adult neurogenesis is unknown. Using global and single‚?źcell targeted gene deletion of subunits contributing to the assembly of GABAARs mediating tonic (őĪ4, őī) or phasic (őĪ2) GABAergic transmission, we demonstrate here in the dentate gyrus of adult mice that GABAARs containing őĪ4, but not őī, subunits mediate GABAergic effects on ce...

Implications of current clinical trials focused on medication overuse and therapeutic prophylaxis.

Authors: Aurora SK (Headache 2011;51;S2:93-100) Chronic migraine (CM) is a complex disorder requiring a multifaceted management approach encompassing lifestyle modification, trigger avoidance, behavioral therapy, pharmacotherapy, patient education and support, management of expectations, and close follow-up. The lack of pharmacotherapies approved by the US Food and Drug Administration (FDA) hinders CM prophylaxis and management. Topiramate, gabapentin, tizanidine, fluoxetine, amitriptyline, and onabotulinumtoxinA have been evaluated for prophylactic treatment of CM in randomized, double-blind, placebo-controlled or active comparator-controlled trials. Additional well-designed, placebo-controlled studies are needed to assess the effectiveness of new and existing treatment options for CM...<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>

Trial of Gabapentin May Have Been a Marketing PloyTrial of Gabapentin May Have Been a Marketing Ploy

The stated aim of the phase 4 STEPS trial was to study efficacy and safety of gabapentin; Instead, it may have been a "seeding trial" to promote the drug's use, researchers suggest. Medscape Medical News (Source: Medscape Today Headlines)

Duloxetine, Pregabalin, and Duloxetine Plus Gabapentin for Diabetic Peripheral Neuropathic Pain Management in Patients With Inadequate Pain Response to Gabapentin: An Open-Label, Randomized, Noninferiority Comparison

CONCLUSION: Duloxetine was noninferior to pregabalin for the treatment of pain in patients with diabetic peripheral neuropathy who had an inadequate pain response to gabapentin. Trial Registration: clinicaltrials.gov Identifier: NCT00385671 (Source: Mayo Clinic Proceedings)

Seizure Drug Trial Called a Form of Marketing (CME/CE)

(MedPage Today) -- A postmarketing study of the epilepsy drug gabapentin (Neurontin) sponsored by its manufacturer was intended mainly to turn its hundreds of clinician-investigators into enthusiasts for the product, said researchers who reviewed the company's internal documents. (Source: MedPage Today Public Health)

Drug Trial Raises Ethics Questions

[New Haven Register, Conn.] From New Haven Register (CT) (June 28, 2011) June 28--NEW HAVEN -- A clinical trial for Neurontin, a popular epilepsy drug, may have been undertaken purely to promote... (Source: Drugs.com - Pharma News)

Neurontin study more marketing than science: report

NEW YORK (Reuters Health) - A study of the safety and effectiveness of the anti-epilepsy drug Neurontin (gabapentin) misled doctors and patients about the point of the research, suggests a new report. (Source: Modern Medicine)<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>

Neurontin Study More Marketing Than Science

A study of the safety and effectiveness of an anti-epilepsy drug mislead doctors and patients about the point of the research, suggests a new report.Source: Reuters Health Related MedlinePlus Page: Epilepsy (Source: MedlinePlus Health News)

Clinical study of epilepsy drug may have served primarily to promote drug and increase prescribing, review suggests

A review of documentation relating to a clinical trial of the epilepsy drug gabapentin suggests that the study may have been a "seeding trial" used to promote the drug and increase prescribing, according to a new report. (Source: ScienceDaily Headlines)

Clinical Study Involving Epilepsy Drug May Have Served Primarily To Promote The Drug And Increase Prescribing

A review of documentation relating to a clinical trial of the epilepsy drug gabapentin suggests that the study may have been a "seeding trial" used to promote the drug and increase prescribing, according to a report in the June 27 issue of Archives of Internal Medicine, one of the JAMA/Archives journals. According to background information in the article, a seeding trial is a clinical trial conducted primarily for marketing purposes and intended to promote the drug and increase prescribing by exposing physician-investigators to it... (Source: Health News from Medical News Today)

Clinical study of epilepsy drug may have been purely promotional

(Yale University) Yale School of Medicine researchers have found that a clinical trial of the epilepsy drug gabapentin may have been a "seeding trial" used by a pharmaceutical company to promote the drug and increase prescriptions, according to a report in the June issue of Archives of Internal Medicine, one of the JAMA/Archives journals. (Source: EurekAlert! - Social and Behavioral Science)<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>

Study of Neurontin: Titrate to Effect, Profile of Safety (STEPS) Trial: A Narrative Account of a Gabapentin Seeding Trial [Original Investigation]

Conclusion&nbsp; The STEPS trial was a seeding trial, used to promote gabapentin and increase prescribing among investigators, and marketing was extensively involved in its planning and implementation. (Source: Archives of Internal Medicine)

Seeding Trials and the Subordination of Science: Comment on "Study of Neurontin: Titrate to Effect, Profile of Safety (STEPS) Trial" [Invited Commentary]

(Source: Archives of Internal Medicine)

Sensitive and Selective Spectrophotometric Determination of Gabapentin in Capsules Using Two Nitrophenols as Chromogenic Agents

Two simple and selective spectrophotometric methods have been proposed for the determination of gabapentin (GBP) in pure form and in capsules. Both methods are based on the proton transfer from the Lewis acid such as 2,4,6-trinitrophenol (picric acid; PA) or 2,4-dinitrophenol (2,4-DNP) to the primary amino group of GBP which works as Lewis base and formation of yellow ion-pair complexes. The ion-pair complexes formed show absorption maximum at 415 and 420 nm for PA and 2,4-DNP, respectively. Under the optimized experimental conditions, Beer's law is obeyed over the concentration ranges of 1.25&#x2013;15.0 and 2.0&#x2013;18.0&#x2009;&#x3bc;g&#x2009;mL&#x2212;1 GBP for PA and 2,4-DNP methods, respectively. The molar absorptivity, Sandell's sensitivity, detection and, quantification limits fo...

US guidelines on the treatment of painful diabetic neuropathy

Source: JAMA, Neurology Area: News The American Academy of Neurology has published an evidence-based guideline on the treatment of painful diabetic neuropathy (PDN).&nbsp; The guideline was established through a systematic review of the published literature (1960 to August 2008) reporting on the efficacy of various pharmacological treatments, including anticonvulsants, antidepressants, and opioids, as well as non-pharmacological treatments (e.g. electrical stimulation, magnetic field treatment, low-intensity laser treatment, and Reiki massage). The guideline authors rate the various therapeutic options based on the quality of the supporting evidence.&nbsp; &nbsp; The main recommendations made with respect to pharmacological therapies are as follows: &nbsp; Anticonvulsants &nbsp;...

Rectus Sheath Catheters for Continuous Analgesia after Laparotomy‚??Without Postoperative Opioid Use

Conclusions.‚?? This report may be the first description of a successful multimodal postoperative analgesic regimen including continuous bilateral rectus sheath blocks without inpatient postoperative opioid use or epidural analgesia following a midline laparotomy. (Source: Pain Medicine)<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>

Replacement of Gabapentin with Pregabalin in Postherpetic Neuralgia Therapy

Conclusion.‚?? It was suggested that the analgesic action of pregabalin in PHN was six times that of gabapentin in terms of effectiveness in dosage conversion. Regarding the side effects, although the incidence of the peripheral edema was higher with pregabalin compared with gabapentin, this finding is not conclusive because the present study was conducted in a small number of subjects. Although pain reduction can be expected to increase with pregabalin dosage, it is necessary to increase the dosage gradually and carefully because of exacerbation of side effects. (Source: Pain Medicine)

Painful Diabetic Peripheral Neuropathy: Consensus Recommendations on Diagnosis, Assessment and Management

AbstractPainful Diabetic peripheral neuropathy (painful DPN) is common, is associated with significant reduction in quality of life and poses major treatment challenges to the practising physician. Although poor glucose control and cardiovascular risk factors are proven to contribute to the aetiology of DPN, risk factors specific for painful DPN remain unknown.A number of instruments have been proven to assess the character, intensity and impact of painful DPN on quality of life, activities of daily living and mood. Management of the patient with DPN must be tailored to individual requirements, taking into consideration co‚?źmorbidities and other factors. Pharmacological agents with proven efficacy for painful DPN include the tricyclic antidepressants (TCA), the selective serotonin and nor...

The fiscal case for legalising marijuana | Samantha McCann

This article was originally published by the Morningside Post and is crossposted by permission of the editorsDrugs policyDrugsDrugs tradeUnited StatesPublic financeHIV infectionAids and HIVMultiple sclerosisHealthCaliforniaSamantha McCannguardian.co.uk &copy; Guardian News & Media Limited 2011 | Use of this content is subject to our Terms & Conditions | More Feeds (Source: Guardian Unlimited Science)

A Randomized, Double-Blind, Placebo-Controlled Study to Assess the Efficacy and Tolerability of Gabapentin Enacarbil in Subjects with Restless Legs Syndrome

Conclusions: GEn 1200 mg and 600 mg significantly improve RLS symptoms and sleep disturbance compared with placebo and are generally well tolerated. Keywords: Gabapentin enacarbil, PIVOT RLS II, restless legs syndrome, GSK1838262, XP13512 (Source: Journal of Clinical Sleep Medicine : JCSM)

An update on analgesics

Recent introduction of new analgesics into the clinic is best described as a slow process with activity classified into two main areas: improving analgesic efficacy/potency and reducing side-effect profile. This review article describes some of the recent advances with an emphasis on use in the acute setting. In this respect, opioids continue to be the mainstay (but not the only) analgesic and there have been important improvements in their clinical effect profile. For example, tapentadol has been introduced as a mixed opioid and norepinephrine uptake inhibitor which, unlike tramadol, does not require metabolic activation and does not suffer from isomer-dependent pharmacodynamics. Opioid antagonists have received much attention recently either used alone, methylnaltrexone (s.c) or alvimopa...<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>

Preoperative Gabapentin for Acute Post‚?źthoracotomy Analgesia: A Randomized, Double‚?źBlinded, Active Placebo‚?źControlled Study

Conclusions:‚?? A single preoperative oral dose of gabapentin (600‚??mg) did not reduce pain scores or opioid consumption following elective thoracotomy, and did not confer any analgesic benefit in the setting of effective multimodal analgesia that included thoracic epidural infusion. (Source: Pain Practice)

GABAPENTIN (Gabapentin) Capsule [Preferred Pharmaceuticals, Inc]

Updated Date: Jun 15, 2011 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

Herpes zoster and postherpetic neuralgia: prevention and management.

Authors: Fashner J, Bell AL Herpes zoster (shingles) is diagnosed clinically by recognition of the distinctive, painful vesicular rash appearing in a unilateral, dermatomal distribution. An estimated 1 million cases occur in the United States each year, and increasing age is the primary risk factor. Laboratory testing, including polymerase chain reaction, can confirm atypical cases. Treatment with acyclovir, famciclovir, or valacyclovir decreases the duration of the rash. Adjunct medications, including opioid analgesics, tricyclic antidepressants, or corticosteroids, may relieve the pain associated with acute herpes zoster. There is conflicting evidence that antiviral therapy during the acute phase prevents postherpetic neuralgia. Postherpetic neuralgia in the cutaneous nerve distribut...

Bifocal Nummular Headache: A Series of 6 New Cases

Conclusion.‚?? Although not frequently found, some patients may have bifocal or multifocal NH. (Source: Headache: The Journal of Head and Face Pain)

Bifocal Nummular Headache: A Series of 6 New Cases.

Conclusion.- Although not frequently found, some patients may have bifocal or multifocal NH. PMID: 21675970 [PubMed - as supplied by publisher] (Source: Headache)<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>

[Pregabalin and gabapentin in multiple sclerosis : Clinical experiences and therapeutic implications.]

CONCLUSION: So far, it is not known whether the investigated agents exert a beneficial influence on the disease course of MS itself beyond a mere symptomatic treatment. Further research efforts and clinical studies are necessary to address this question. PMID: 21647743 [PubMed - as supplied by publisher] (Source: Der Nervenarzt)

Akathisia Induced by Gabapentin Withdrawal (June).

CONCLUSIONS If gabapentin discontinuation is desired, it is prudent to gradually taper the dose to avoid withdrawal symptoms, which may occur after as little as 1 month of treatment. Should the patient experience withdrawal symptoms, the optimal treatment is to restart gabapentin. PMID: 21652784 [PubMed - as supplied by publisher] (Source: The Annals of Pharmacotherapy)

Older Men More Likely To Lose The Ability To Orgasm Due To Gabapentin

This study appears in the current issue of the American Journal of Geriatric Pharmacotherapy. Anticonvulsants are the fastest growing prescribed medication in the baby boomer generation... (Source: Health News from Medical News Today)

BUSM study finds older men more likely to lose the ability to orgasm due to gabapentin

(Boston University Medical Center) Boston University School of Medicine researchers have found that gabapentin, (trade name Neurontin) a medication commonly used to treat neuropathic pain, seizures and bipolar disease in older and elderly patients, seems to have a higher incidence of anorgasmia, or failure to experience orgasm, than previously reported. (Source: EurekAlert! - Social and Behavioral Science)

The Median Effective Dose of Ketamine and Gabapentin in Opioid-Induced Hyperalgesia in Rats: An Isobolographic Analysis of Their Interaction.

Conclusion: The isobolographic analysis demonstrated that the combination of the 2 drugs produces effective antihyperalgesia with a supraadditive (synergistic) action. PMID: 21642613 [PubMed - as supplied by publisher] (Source: Anesthesia and Analgesia)<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>

Oscillatory Eye Movements Resembling Pendular Nystagmus in Normal Juvenile Macaques [Eye Movements, Strabismus, Amblyopia, and Neuro-Ophthalmology]

Conclusions. The developmentally transient ocular oscillations occurring in monkeys during pursuit training has properties resembling pendular nystagmus. Both smooth pursuit and a neural integrator may contribute to these ocular oscillations. Analysis using an efference-copy pursuit model supports the interpretation herein. (Source: Investigative Ophthalmology)

Neurocognitive Performance, Alcohol Withdrawal, and Effects of a Combination of Flumazenil and Gabapentin in Alcohol Dependence

Conclusions:‚?? Taken together, these data suggest that acute AW accounts for a small proportion of variance in neurocognitive performance, that gabapentin and flumazenil slightly improve response inhibition during early abstinence, and that such improvement may somewhat reduce later drinking. However, these medications may not affect other neurocognitive domains. (Source: Alcoholism: Clinical and Experimental Research)

Neurocognitive Performance, Alcohol Withdrawal, and Effects of a Combination of Flumazenil and Gabapentin in Alcohol Dependence.

Conclusions:‚?? Taken together, these data suggest that acute AW accounts for a small proportion of variance in neurocognitive performance, that gabapentin and flumazenil slightly improve response inhibition during early abstinence, and that such improvement may somewhat reduce later drinking. However, these medications may not affect other neurocognitive domains. PMID: 21631542 [PubMed - as supplied by publisher] (Source: Alcoholism, Clinical and Experimental Research)

Physican-directed (off-label) use of recombinant bone morphogenic protein-2: let us do it well!

As the entire health-care delivery system in this country comes under increasing pressure to control and reduce costs, the ‚??off-label‚?Ě applications of technology and pharmaceuticals have come under intense scrutiny. This targeting derives from the fact that newly introduced products are more expensive, and there is often a widespread physician-directed use outside of the original Food and Drug Administration (FDA)-approved indication. This wide net of physician-directed use has resulted in significant patient benefit for conditions outside of the original FDA approval. Examples I would cite include the use of lateral mass screw rod fixation for posterior cervical spine fusion and the use of gabapentin for subacute or chronic neuropathic pain syndromes. This wide net of physician-direct...

Vertebral body osteolysis after minimal-access transforaminal interbody fusion

Presented is a 63-year-old female who previously underwent an L5‚??S1 fusion and developed suprajacent degeneration and radiculopathy. She underwent a minimal-access transforaminal lumbar interbody fusion with a Capstone cage filled with 6 mg of recombinant human bone morphogenetic protein-2 on an absorbable collagen sponge inserted from the left side. She subsequently developed postoperative left lower extremity radiculitis that was refractory to narcotics and gabapentin several months after the surgery (). (Source: The Spine Journal)<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>

Efficacy of Gabapentin Enacarbil vs Placebo in Patients with Postherpetic Neuralgia and a Pharmacokinetic Comparison with Oral Gabapentin

Conclusions.‚?? GEn was effective in providing PHN pain relief, improved gabapentin exposure compared with gabapentin capsules, and was generally safe and well tolerated in patients with PHN. (Source: Pain Medicine)

NEURONTIN (Gabapentin) Capsule [Cardinal Health]

Updated Date: May 27, 2011 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

A comparative study of the pharmacokinetics of traditional and automated dosing/blood sampling systems using gabapentin

Conclusion: The described ADI/ABS method was found to be a useful drug development tool for accelerating the pace of preclinical in vivo studies and for obtaining reliable and accurate PK parameters even from single animals as it minimized interanimal and physiological variations. (Source: Indian Journal of Pharmacology)

Randomized polysomnography study of gabapentin enacarbil in subjects with restless legs syndrome

AbstractWe assessed the efficacy and tolerability of gabapentin enacarbil in the treatment of moderate to severe primary restless legs syndrome and associated sleep disturbance. This was a multicenter, randomized, double‚?źblind, placebo‚?źcontrolled, 2‚?źperiod crossover polysomnography study of gabapentin enacarbil 1200 mg or placebo taken once daily. Subjects were randomized 1:1 to a sequence of gabapentin enacarbil:placebo or placebo:gabapentin enacarbil, receiving each treatment for 4 weeks. The primary end point was the mean change from baseline at weeks 4 and 10 (4/10) last observation carried forward in wake time during sleep. The key secondary end point was the mean change from baseline at weeks 4/10 last observation carried forward in periodic limb movements associated with arous...

HORIZANT (Gabapentin Enacarbil) Tablet [GlaxoSmithKline LLC]

Updated Date: May 23, 2011 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>

Gabapentin-induced sexual dysfunction.

This report addresses dose-dependent gabapentin-induced sexual dysfunction reaching total sexual dysfunction (loss of libido, anejaculation, anorgasmia, and impotence) at a total daily dose of only 300mg. PMID: 21612983 [PubMed - as supplied by publisher] (Source: Epilepsy and Behaviour)

Older Men More Likely to Lose the Ability to Orgasm Due to Gabapentin According to BUSM Researchers

This study appears in the current issue of the American Journal of Geriatric Pharmacotherapy. (Source: Boston University News Releases)

Neuroprotective effects of gabapentin on spinal cord ischemia-reperfusion injury in rabbits.

Conclusions Gabapentin demonstrated significant neuroprotection after early phases of ischemic injury. Further studies with different experimental settings including neurological outcome are required to achieve conclusive results. PMID: 21599445 [PubMed - as supplied by publisher] (Source: Journal of Neurosurgery.Spine)

Anorgasmia with Gabapentin May Be Common in Older Patients.

CONCLUSION: Gabapentin-associated anorgasmia may be more common in older patients and appears to be dose dependent. PMID: 21602106 [PubMed - as supplied by publisher] (Source: The American Journal of Geriatric Pharmacotherapy)

Foetal exposure to newer antiepileptic drugs unlikely to cause major birth defects?

Source: JAMA Area: News A population-based observational study found no significant increase in the risk of major birth defects associated with exposure to newer antiepileptic drugs. &nbsp; Antiepileptic drugs are used in women of child-bearing potential, both for epilepsy and for other indications, with estimates suggesting that between 0.2% and 0.5% of pregnant women are exposed to one or more. The teratogenic potential of the various older drugs in this group is established, however there is limited evidence available for the newer agents. This population-based cohort study was intended to clarify the risk associated with newer antiepileptic drugs. The authors constructed a cohort of all live births in Denmark between January 1996 and September 2008 and assessed first-trimester exp...<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>

4 years wept

On call pager ring, a thousand times before. 14-year-old boy, left femur osteosarcoma, Mets to lungs, a palliative AKA. Consult: phantom limb pain with emotion, Please advise. A gentle morphine drip, QID neurontin, Social worker at the bedside. He rallies from mute to playful, anger to manic. Fights, tires, ignores, repents. Behaves like a child, as he is a child. And I weep, in a moment, hope forgotten. Weep of 4&nbsp;years training that did not sway me. "The hurt, it swings, but I can take it." "It burns, my leg, a pendulum, I feel it." "Don't cry," he smiles, and clasps the stump. "...like a pendulum," he repeats, and smiles, and cries. And I want to feel his hurt, I want to take his pain. To selfishly feel better. Competing interestNone. Provenance and peer reviewNot commissioned; no...

Newer-Generation Antiepileptic Drugs and the Risk of Major Birth Defects [Original Contribution]

Conclusion Among live-born infants in Denmark, first-trimester exposure to lamotrigine, oxcarbazepine, topiramate, gabapentin, or levetiracetam compared with no exposure was not associated with an increased risk of major birth defects. (Source: JAMA)

Evidence-based guideline: Treatment of painful diabetic neuropathy: Report of the American Academy of Neurology, the American Association of Neuromuscular and Electrodiagnostic Medicine, and the American Academy of Physical Medicine and Rehabilitation

Objective: To develop a scientifically sound and clinically relevant evidence-based guideline for the treatment of painful diabetic neuropathy (PDN). Methods: We performed a systematic review of the literature from 1960 to August 2008 and classified the studies according to the American Academy of Neurology classification of evidence scheme for a therapeutic article, and recommendations were linked to the strength of the evidence. The basic question asked was: "What is the efficacy of a given treatment (pharmacologic: anticonvulsants, antidepressants, opioids, others; and nonpharmacologic: electrical stimulation, magnetic field treatment, low-intensity laser treatment, Reiki massage, others) to reduce pain and improve physical function and quality of life (QOL) in patients with PDN?" Res...

Suicide by Gabapentin Overdose. - Middleton O.

Gabapentin is an antiepileptic drug that is prescribed for both FDA-approved and multiple off-label conditions, and has a relatively safe side-effect profile. Rare cases of overdose-related adverse effects have been reported in the literature. Described he... (Source: SafetyLit: All (Unduplicated))

A Drug That Is Increasingly Prescribed, Pregabalin, May Cause Dependence And The Doctors Do Not Know It

A report in the current issue of Psychotherapy and Psychosomatics by a group of European investigators headed by Fabrizio Schifano (UK) has explored the potential for dependence of pregabalin using patients' online reports. Pregabalin is a prescription drug licensed to treat generalized anxiety disorder, partial epilepsy, and neuropathic pain. Pregabalin is structurally related to gabapentin and shares some therapeutic indications with clonazepam. However, both clonazepam and gabapentin possess an identified abuse potential, at least in selected populations... (Source: Health News from Medical News Today)<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>

NEURONTIN (Gabapentin) Capsule NEURONTIN (Gabapentin) Tablet, Film Coated NEURONTIN (Gabapentin) Solution [Parke-Davis Div Of Pfizer Inc]

Updated Date: May 6, 2011 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

THERAPENTIN-90 (Gabapentin, .Gamma.-Aminobutyric Acid) Kit [Physician Therapeutics LLC]

Updated Date: May 6, 2011 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

Suicide by Gabapentin Overdose.

Authors: Middleton O ‚?? Gabapentin is an antiepileptic drug that is prescribed for both FDA-approved and multiple off-label conditions, and has a relatively safe side-effect profile. Rare cases of overdose-related adverse effects have been reported in the literature. Described herein are the circumstances and autopsy findings of a 62-year-old woman with a history of depression, whose death was caused by intentional ingestion of excess gabapentin. The postmortem peripheral blood gabapentin concentration as determined by high-performance liquid chromatography/tandem mass spectroscopy was 88‚??őľg/mL. Previously reported cases of individuals surviving gabapentin overdoses are discussed and compared with this case. Based on a review of the available literature, this appears to be the firs...

Dose-dependent opposite effects of gabapentin on the depressive action of morphine on a C-fibre reflex in the rat.

Authors: Pollin B, Roy-Ledoux R, le Bars D, Adam F Gabapentin is a structural analogue of gamma-amino-butyric acid with anticonvulsant activity. Recently, indications for its use were extended to the management of acute pain in the postoperative period. The effects of pre-administration of gabapentin on the depressive action of intravenous morphine were studied on the C-fibre reflex elicited by a wide range of stimulus intensities. The reflex was elicited by electrical stimulation of the sural nerve and recorded from the ipsilateral biceps femoris muscle in halothane anaesthetized rats with either an intact neuraxis or a brainstem previously transected at the level of the obex. As previously reported, 6 mg/kg intravenous morphine both increased the threshold and decreased the slope of...

On the Track of New Multicomponent Gabapentin Crystal Forms: Synthon Competition and pH Stability

Crystal Growth & DesignDOI: 10.1021/cg200008z (Source: Crystal Growth and Design)<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>

Effects of antiepileptic drugs on GABA release from rat and human neocortical synaptosomes

In conclusion, reduction of GABA release by AEDs may be the actual objective in a pathologically altered neuronal network where GABA acts in a depolarizing fashion. Content Type Journal ArticlePages 1-11DOI 10.1007/s00210-011-0636-8Authors M. Kammerer, Section of Clinical Neuropharmacology, Department of Neurosurgery, Neurozentrum, Albert-Ludwigs University, 79106 Freiburg, GermanyM. P. Rassner, Section of Clinical Neuropharmacology, Department of Neurosurgery, Neurozentrum, Albert-Ludwigs University, 79106 Freiburg, GermanyT. M. Freiman, Department of Neurosurgery, Neurozentrum, Albert-Ludwigs University, 79106 Freiburg, GermanyT. J. Feuerstein, Section of Clinical Neuropharmacology, Department of Neurosurgery, Neurozentrum, Albert-Ludwigs University, 79106 Freiburg, Germany ...

The analgesic and antiemetic efficacy of gabapentin or ergotamine/caffeine for the treatment of postdural puncture headache.

Conclusions: Gabapentin significantly reduced pain, nausea and vomiting compared to Cafergot in patients with PDPH. Lastly, we hypothesize that the gabaergic action of gabapentin, perhaps combined with other mechanisms, such as calcium channel blockade, may be responsible for its remarkable effects on PDPH. PMID: 21536541 [PubMed - as supplied by publisher] (Source: Advances in Medical Sciences)

FDA Approved Gabapentin Prodrug for Treating RLS

The Food and Drug Administration announced the approval of an extended-release form of gabapentin for moderate to severe restless legs syndrome. The drug, known as Horizant (gabapentin enacarbil), is a prodrug of gabapentin. It was developed by XenoPort Inc. of Santa Clara, Calif., and GlaxoSmithKline. (Source: Clinical Neurology News)

Digest

AbstractNewsNew DH report on mental health promotionThe Department of Health has published an economic evaluation of the benefits of mental health promotion and preventing mental illness (www.dh.gov.uk/prod_consum_dh/groups/dh_digitalassets/documents/digitalasset/dh_126386.pdf). Edited by Professor Martin Knapp and colleagues from the London School of Economics and Political Science, with contributions from researchers based largely in the south east of England, the 43‚?źpage report summarises the financial burden and cost effectiveness of interventions to tackle a range of mental health issues in the home, school and workplace. It concludes that many interventions offer outstanding value for money and several are cost‚?źsaving, though the pay‚?źoff period can be several years.Safinamide h...

Antiepileptic drug use in community-dwelling and institutionalized elderly: a nationwide study of over 1 300 000 older people

Conclusions&nbsp;&nbsp;AED use seems to be common among Swedish institutionalized elderly, and institutionalization is a strong determinant of AED use. Our results may also indicate an off-label prescribing of AEDs as an alternative to psychotropics in the institutional setting. This finding needs to be confirmed by others and evaluated with respect to outcomes of this treatment in institutionalized elderly. Content Type Journal ArticlePages 1-7DOI 10.1007/s00228-011-1051-2Authors Kristina Johnell, Aging Research Center, Karolinska Institutet and Stockholm University, Gävlegatan 16, 113 30 Stockholm, SwedenJohan Fastbom, Aging Research Center, Karolinska Institutet and Stockholm University, Gävlegatan 16, 113 30 Stockholm, Sweden Journal European Journal of Clinical ...<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>

Validation of the Post Sleep Questionnaire for assessing subjects with Restless Legs Syndrome: Results from two double-blind, multicenter, placebo-controlled clinical trials

The objective of this study was to validate a new measure, the Post Sleep Questionnaire (PSQ), to assess sleep dysfunction in subjects with moderate-to-severe RLS symptoms. Methods: Pooled data were analyzed from 2 12-week, randomized, placebo-controlled trials of gabapentin enacarbil (N=540). At baseline and Week 12, subjects completed the PSQ and other validated health surveys: IRLS Rating Scale, Clinical Global Impression of Improvement (CGI-I), Profile of Mood States (POMS), Medical Outcomes Study Scale-Sleep (MOS-Sleep), and RLS-Quality of Life (RLSQoL). Pooled data were used post hoc to examine the convergent, divergent, and known-group validity and the responsiveness of the PSQ. Results: Convergent validity was demonstrated by significant correlations between baseline PSQ items and ...

Gabapentin reduces infarct volume but does not suppress peri-infarct depolarizations

Authors: Ulrike Hoffmann, Jeong Hyun Lee, Tao Qin, Katharina Eikermann-Haerter & Cenk Ayata (Source: Journal of Cerebral Blood Flow)

Clinical comparability of the new antiepileptic drugs in refractory partial epilepsy: A systematic review and meta‚?źanalysis

SummaryPurpose:‚?? Evaluate the clinical comparability of new antiepileptic drugs (AEDs) in partial refractory epilepsy.Methods:‚?? Systematic review of randomized trials (RCTs) comparing a new AED (add‚?źon treatment) with placebo or another AED. Primary outcomes: responder (‚?•50% seizure reduction) and withdrawal (tolerability) rates. Pooled estimates of odds ratios (ORs) and number needed treat/harm (NNT/NNH) taking into account baseline risk were derived by random‚?źeffects meta‚?źanalysis. Adjusted frequentist indirect comparisons between AEDs were estimated.Key Findings:‚?? Sixty‚?źtwo placebo‚?źcontrolled (12,902 patients) and eight head‚?źto‚?źhead RCTs (1,370 patients) were included. Pooled ORs for responder and withdrawal rates (vs. placebo) were 3.00 [95% confidence interval (C...

Horizant (gabapentin enacarbil) - updated on RxList

Horizant (gabapentin enacarbil) drug description - FDA approved labeling for prescription drugs and medications at RxList (Source: RxList - New and Updated Drug Monographs)

Interchangeability of generic anti-epileptic drugs: a quantitative analysis of topiramate and gabapentin

Conclusion&nbsp;&nbsp;Our results strongly indicate that the so-called drifting problem upon generic‚??generic substitution does not result in important differences in exposure upon exchanging topiramate generics or gabapentin generics. Content Type Journal ArticlePages 1-10DOI 10.1007/s00228-011-1041-4Authors Marc Maliepaard, Medicines Evaluation Board (MEB-CBG), MEB-CBG, Radboud University Nijmegen Medical Centre, P.O. Box¬†9101, 6500 HB, Nijmegen, The NetherlandsNikola Banishki, MEB-CBG, P.O. Box¬†16229, 2500 BE, Den Haag, The NetherlandsChristine C. Gispen-de Wied, MEB-CBG, P.O. Box¬†16229, 2500 BE, Den Haag, The NetherlandsSteven Teerenstra, Department of Epidemiology, Biostatistics and HTA, Radboud University Nijmegen Medical Centre, P.O. Box¬†9101, 6500 HB, Nijmegen, The...<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>

Chronic intrathecal infusion of gabapentin prevents nerve ligation-induced pain in rats

Conclusions We showed a preventative effect of intrathecal gabapentin on the development of nerve injury-induced mechanical allodynia and thermal hyperalgesia. Our data suggest that continuous intrathecal gabapentin may be considered as an alternative for the prevention of nerve injury-induced pain. (Source: British Journal of Anaesthesia)

Treatment Options in Juvenile Myoclonic Epilepsy

Opinion statement&nbsp;&nbsp;Juvenile myoclonic epilepsy (JME) is characterized by excellent response to treatment, if diagnosed correctly. Lifestyle advice is an integral part of the treatment of JME; it should include recommendations on avoidance of common triggers such as sleep deprivation and alcohol excess and emphasis on the importance of compliance with medication. The drug of first choice in the treatment of JME is sodium valproate, which has a response rate of up to 80%. Valproate should be avoided in women of childbearing age because of significantly increased risks of fetal malformations and neurodevelopmental delay. Levetiracetam or lamotrigine are alternative first-line options if valproate is contraindicated. With limited data from trials to support either of these drug...

Gabapentin May Help Prevent Postherpetic Neuralgia

A study suggests that adding gabapentin to antiviral therapy in patients with acute herpes zoster reduces the incidence of postherpetic neuralgia. Medscape Medical News (Source: Medscape Today Headlines)

HORIZANT (Gabapentin Enacarbil) Tablet [GlaxoSmithKline LLC]

Updated Date: Apr 14, 2011 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

Tetraaquatetrakis{őľ2-[1-(carboxylatomethyl)cyclohexyl]methanaminium}bis(őľ3-hydroxido)bis(nitrato-őļ2O,O‚?≤)tetrazinc(II)

As the title gabapentin complex, [Zn4(OH)2(NO3)2(C9H17NO2)4(H2O)4](NO3)4 is located about a centre of inversion, the asymmetric unit contains two disordered nitrate ions and half a complex molecule. The two zinc ions have different coordination environments: one is slightly distorted octahedral and the other is trigonal‚??pyramidal. The conformation of the gabapentin molecule is defined by the formation of two intramolecular O‚??H...O hydrogen bonds. Furthermore, the ammonium H atoms are involved in numerous hydrogen bonds with the disordered nitrate anions. (Source: Acta Crystallographica Section E)<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>

New Analyses of Safety and Efficacy Data of Depomed's Gralise(TM) to be Presented at the 63rd Annual Meeting of the American Academy of Neurology

MENLO PARK, Calif., April 12, 2011 (GLOBE NEWSWIRE) -- Depomed, Inc. (Nasdaq:DEPO) today announced that two new analyses of phase 3 clinical data of Gralise(tm) (gabapentin), a once-daily evening formulation of gabapentin for management of postherpetic neuralgia (PHN), will be presented this week at the 63rd Annual Meeting of the American Academy of Neurology in Honolulu, Hawaii. A poster to be presented this evening concludes that there was no effect of previous treatment with gabapentin and pregabalin on the efficacy or adverse event (AE) profile of Gralise. An oral presentation to be given Thursday evening will review the overall tolerability and safety dataset from two phase 3 clinical trials of once-daily Gralise. Gralise was recently approved by the U.S. Food and Drug Administration ...

FDA approves gabapentin enacarbil for RLS

FDA has approved gabapentin enacarbil (Horizant Extended-Release Tablets, GlaxoSmithKline and XenoPort), a once-daily treatment for moderate-to-severe restless legs syndrome, also known as Ekbom disease. It is the first medication in its class to be approved for this condition. (Source: Modern Medicine)

FDA Approves New Gabapentin Formulation for RLS

Gabapentin enacarbil has been approved by the US Food and Drug Administration for the treatment of moderate-to-severe primary restless legs syndrome in adults. Medscape Medical News (Source: Medscape Today Headlines)

Are Antiepileptic Drugs Used in the Treatment of Migraine Associated with an Increased Risk of Suicidality?

Abstract&nbsp;&nbsp;Three antiepileptic drugs (AEDs), valproic acid, gabapentin, and topiramate (TPM), are used frequently in the prophylactic treatment of migraines. In December 2008, the US Food and Drug Administration issued a warning suggesting that the use of all AEDs is associated with an increased risk of suicidal ideation and behavior. This warning has been received by the medical community with great skepticism, and the validity of the findings of the meta-analysis that led to its publication has been questioned because of various methodological problems. Yet, migraine by itself is associated with an increased risk of suicidal ideation and behavior as well as with an increased risk of psychiatric disorders that facilitate the development of suicidal behavior. Furthermore, TP...

HORIZANT (Gabapentin Enacarbil) Tablet [GlaxoSmithKline LLC]

Updated Date: Apr 11, 2011 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>

Incidence of Postherpetic Neuralgia After Combination Treatment With Gabapentin and Valacyclovir in Patients With Acute Herpes Zoster: Open-label Study [Study]

Conclusion&nbsp; The combination of gabapentin and valacyclovir administered acutely in patients with herpes zoster reduces the incidence of postherpetic neuralgia. Trial Registration&nbsp; clinicaltrials.gov Identifier: NCT01250561. (Source: Archives of Dermatology)

Therapy for hyperthermia‚?źinduced seizures in Scn1a mutant rats

SummaryPurpose:‚?? Mutations in the SCN1A gene, which encodes the őĪ1 subunit of voltage‚?źgated sodium channels, cause generalized epilepsy with febrile seizures plus (GEFS+) and severe myoclonic epilepsy of infancy (SMEI). N1417H‚?źScn1a mutant rats are considered to be an animal model of human FS+ or GEFS+. To assess the pharmacologic validity of this model, we compared the efficacies of eight different antiepileptic drugs (AEDs) for the treatment of hyperthermia‚?źinduced seizures using N1417H‚?źScn1a mutant rats.Methods:‚?? AEDs used in this study included valproate, carbamazepine (CBZ), phenobarbital, gabapentin, acetazolamide, diazepam (DZP), topiramate, and potassium bromide (KBr). The effects of these AEDs were evaluated using the hot water model, which is a model of experimental ...

Horizant for Restless Legs Syndrome FDA Approved

On April 6, the U.S. Food and Drug Administration approved Horizant Extended Release Tablets (gabapentin enacarbil), a once-daily treatment for moderate-to-severe restless legs syndrome (RLS). (Source: Disabled World)

Restless Legs Syndrome in Children: A Review and Update on Pharmacological Options.

Authors: Frenette E Restless legs syndrome (RLS), formally identified and described by Ekbom in the 1940s, is a common clinical disorder, characterized by an overwhelming urge to move the legs, often accompanied by uncomfortable and unpleasant sensations. This impulse can also be present in the upper limbs or other parts of the body. Well recognized in the adult population, the symptoms associated with this condition have commonly been reported to originate in childhood. However, identifying prospectively children suffering from RLS is still a challenging issue. Iron deficiency has been recognized as a feature frequently associated with RLS. Some authors also make a connection with the deficiency, RLS and other common problems encountered in children, such as attention deficit disorder...

FDA Okays Seizure Drug for RLS

WASHINGTON (MedPage Today) -- The FDA has approved gabapentin enacarbil (Horizant) for the treatment of moderate-to-severe primary restless legs syndrome (RLS). (Source: MedPage Today Psychiatry)<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>

FDA approves Horizant to treat restless legs syndrome

On April 6, the U.S. Food and Drug Administration approved Horizant Extended Release Tablets (gabapentin enacarbil), a once-daily treatment for moderate-to-severe restless legs syndrome (RLS). (Source: Food and Drug Administration)

GlaxoSmithKline And XenoPort Receive FDA Approval For Horizant‚?Ę - - New Treatment For Moderate-To-Severe Primary Restless Legs Syndrome

GlaxoSmithKline (NYSE: GSK) and XenoPort, Inc. (Nasdaq: XNPT) announced Wednesday that the U.S. Food and Drug Administration (FDA) has approved Horizant‚?Ę (gabapentin enacarbil) Extended-Release Tablets for the treatment of moderate-to-severe primary Restless Legs Syndrome in adults. Horizant is not recommended for patients who are required to sleep during the daytime and remain awake at night. The efficacy of Horizant in the treatment of patients with moderate-to-severe primary Restless Legs Syndrome was demonstrated in two 12-week clinical trials in adults... (Source: Health News from Medical News Today)

FDA Approves Horizant To Treat Restless Legs Syndrome

On April 6, the U.S. Food and Drug Administration approved Horizant Extended Release Tablets (gabapentin enacarbil), a once-daily treatment for moderate-to-severe restless legs syndrome (RLS). (Source: Pharmaceutical Online News)

GlaxoSmithKline and XenoPort Receive FDA Approval for Horizant

LONDON & RESEARCH TRIANGLE PARK, N.C. & SANTA CLARA, Calif.--(BUSINESS WIRE)--Apr 6, 2011 - GlaxoSmithKline and XenoPort, Inc. announced Wednesday that the U.S. Food and Drug Administration (FDA) has approved Horizant (gabapentin enacarbil)... (Source: Drugs.com - New Drug Approvals)

FDA approves HorizantT (gabapentin enacarbil) for treatment of primary restless legs syndrome

Source: PharmaLive Area: News The FDA has approved HorizantT (gabapentin enacarbil) extended-release tablets for the treatment of moderate-to-severe primary restless legs syndrome in adults. &nbsp; Horizant is not recommended for patients who are required to sleep during the daytime and remain awake at night. Its efficacy has been demonstrated in two 12-week clinical trials in adults. Once absorbed, Horizant is converted into gabapentin, which binds to a specific type of calcium channel but does not exhibit affinity for other common receptors. The exact mechanism of action of Horizant in this setting is unknown. &nbsp; Horizant is not interchangeable with other gabapentin products because of differing pharmacokinetic profiles- the same dose of Horizant results in different plasma ...<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>

Late-breaking news: FDA approves gabapentin enacarbil for RLS

FDA has approved gabapentin enacarbil (Horizant Extended-Release Tablets, GlaxoSmithKline and XenoPort), a once-daily treatment for moderate-to-severe restless legs syndrome, also known as Ekbom disease. It is the first medication in its class to be approved for this condition. (Source: Modern Medicine)

GlaxoSmithKline and XenoPort receive FDA approval for Horizant‚?Ę

GlaxoSmithKline (NYSE: GSK) and XenoPort, Inc. (Nasdaq: XNPT) announced Wednesday that the U.S. Food and Drug Administration (FDA) has approved Horizant‚?Ę (gabapentin enacarbil) Extended-Release Tablets for the treatment of moderate-to-severe primary Restless Legs Syndrome in adults. (Source: GSK news)

Gabapentin for the prevention of chemotherapy- induced nausea and vomiting: a pilot study

Conclusions&nbsp;&nbsp;Gabapentin is a low-cost strategy to improve complete control of CINV, specially delayed CINV control. Content Type Journal ArticlePages 1-6DOI 10.1007/s00520-011-1138-4Authors Felipe Melo Cruz, Rua Venezuela, 501, apto 24, Centro, Santo André, Brazil 09030-310Daniel de Iracema Gomes Cubero, Disciplina de Hematologia e Oncologia, Faculdade de Medicina do ABC, Av. Príncipe de Gales, n. 821, anexo 3, Santo André, São Paulo, 09060-650 BrazilPatrícia Taranto, Disciplina de Hematologia e Oncologia, Faculdade de Medicina do ABC, Av. Príncipe de Gales, n. 821, anexo 3, Santo André, São Paulo, 09060-650 BrazilTatiana Lerner, Disciplina de Hematologia e Oncologia, Faculdade de Medicina do ABC, Av. Príncipe de Gales, n. 821, anexo 3, Santo André, São Paulo,...

Gabapentin for the treatment of hot flashes in women with natural or tamoxifen-induced menopause: a systematic review and meta-analysis

Source: DARE Area: Evidence > Drug Specific Reviews CRD Summary: This review investigated the efficacy and tolerability of gabapentin for the treatment of hot flashes in menopausal women. Gabapentin was associated with reductions in the severity and frequency of hot flashes in menopausal women, but there was substantial variation in the results across the included trials. The authors' conclusions appear to be reliable based on the evidence presented. CRD Commentary: The review addressed a clear question and the criteria for including studies in the review were stipulated. The literature search was confined to English-language studies, so language bias cannot be ruled out. A number of sources were searched for relevant studies and efforts were made to retrieve unpublished studies. Steps ...

Pharmacotherapy of vestibular and ocular motor disorders, including nystagmus

Abstract&nbsp;&nbsp;We review current pharmacological treatments for peripheral and central vestibular disorders, and ocular motor disorders that impair vision, especially pathological nystagmus. The prerequisites for successful pharmacotherapy of vertigo, dizziness, and abnormal eye movements are the ‚??4 D‚??s‚?Ě: correct diagnosis, correct drug, appropriate dosage, and sufficient duration. There are seven groups of drugs (the ‚??7 A‚??s‚?Ě) that can be used: antiemetics; anti-inflammatory, anti-M√©ni√®re‚??s, and anti-migrainous medications; anti-depressants, anti-convulsants, and aminopyridines. A recovery from acute vestibular neuritis can be promoted by treatment with oral corticosteroids. Betahistine may reduce the frequency of attacks of M√©ni√®re‚??s disease. The aminopyridin...<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>

Dementia in Parkinson‚??s Disease

Opinion statement&nbsp;&nbsp;Dementia in Parkinson‚??s disease encompasses a spectrum relating to motor, psychiatric, and cognitive symptoms that are classified as either Dementia with Lewy Bodies (DLB) (initial cognitive symptoms) or Parkinson‚??s Disease Dementia (PDD) (initial motor signs preceding cognitive symptoms by at least a year). Anticholinergic and antipsychotic drugs have a high risk of adverse cognitive and/or motor effects, so their use should be minimized or avoided. Neuroleptic sensitivity is a severe psychomotor adverse reaction that is particularly associated with potent dopamine-blocking agents such as haloperidol. It occurs in up to 50% of individuals with PDD or DLB. Mild psychotic symptoms should first be addressed by reducing anticholinergic and/or dopaminergi...

Gabapentin for chronic neuropathic pain and fibromyalgia in adults

Source: Cochrane Database of Systematic Reviews Area: Evidence > Drug Specific Reviews Background This review updates parts of two earlier Cochrane reviews investigating effects of gabapentin in chronic neuropathic pain (pain due to nerve damage). Antiepileptic drugs are used to manage pain, predominantly for chronic neuropathic pain, especially when the pain is lancinating or burning. &nbsp; Objectives To evaluate the analgesic effectiveness and adverse effects of gabapentin for chronic neuropathic pain management. &nbsp; Search strategy We identified randomised trials of gabapentin in acute, chronic or cancer pain from MEDLINE, EMBASE, and CENTRAL. We obtained clinical trial reports and synopses of published and unpublished studies from Internet sources. The date of the most r...

Putting evidence into practice.

Authors: Kaplan M, Mahon S, Cope D, Keating E, Hill S, Jacobson M Survival rates for people treated for breast or prostate cancer have increased steadily since 2000, which has been attributed to advances in early detection and improvements in treatments. However, breast and prostate cancer therapies that target estrogen and testosterone production are associated with hormone-deprivation symptoms-most commonly hot flashes-that may have a significant negative impact on quality of life. Compared to the healthy population, hot flashes occur most often in these two groups, so the authors conducted a literature search specifically for evidence-based interventions to manage hot flashes experienced by women treated for breast cancer and men treated for prostate cancer. The interventions review...

Evidence-based Guideline: Treatment of Painful Diabetic Neuropathy: Report of the American Academy of Neurology, the American Association of Neuromuscular and Electrodiagnostic Medicine, and the American Academy of Physical Medicine and Rehabilitation

Efficacy of gabapentin on subjective idiopathic tinnitus: A randomized, double-blind, placebo-controlled trial.

Authors: Dehkordi MA, Abolbashari S, Taheri R, Einolghozati S Tinnitus can cause extreme morbidity. Despite many attempts to find a treatment for idiopathic cases, they remain difficult to manage. Because nerve injury is one of the suspected etiologies of tinnitus and because gabapentin has been found to be effective in treating nerve injuries, some authors have attempted to determine if gabapentin has a role in treating tinnitus. Although gabapentin was found to be ineffective for tinnitus in these previous studies, to the best of our knowledge no studies have been performed that took into consideration the presence of various accompanying factors and concomitant diseases that might influence its effect. We conducted a prospective, randomized, double-blind, placebo-controlled clinical...<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>

Gabapentin Combined With Naltrexone for the Treatment of Alcohol Dependence.

Conclusions: The addition of gabapentin to naltrexone improved drinking outcomes over naltrexone alone during the first 6 weeks after cessation of drinking. This effect did not endure after gabapentin was discontinued. PMID: 21454917 [PubMed - as supplied by publisher] (Source: The American Journal of Psychiatry)

Effects of antiepileptic drugs on glutamate release from rat and human neocortical synaptosomes

Abstract&nbsp;&nbsp;Aim of this study was to learn whether the antiepileptic drugs (AEDs) carbamazepine, lamotrigine, phenytoin, gabapentin, pregabalin, levetiracetam, and valproate (all at 100&nbsp;őľM) presynaptically influence the neurotransmission of the excitatory transmitter glutamate. The effects of these frequently used AEDs were examined on 3H-glutamate release from superfused synaptosomes of both rat and human neocortex. Release was evoked by elevation of buffer [K+] from 3 to 15&nbsp;mM or by the Na+ channel activator veratridine (1, 3.2, and 10&nbsp;őľM). Buffer [K+] elevation induced 3H-glutamate exocytosis, which was Ca2+-, but not Na+-, dependent and which was accompanied only in human tissue by release through transporter reversal. In rat tissue, release was diminished by...

AAPM: New Choices Emerge for Neuropathy Tx

WASHINGTON (MedPage Today) -- Switching to duloxetine (Cymbalta) or pregabalin (Lyrica) can produce pain relief for patients with diabetic neuropathy who stop responding to gabapentin (Neurontin), researchers suggested here. (Source: MedPage Today Psychiatry)

Gabapentin for chronic neuropathic pain and fibromyalgia in adults.

Authors: Moore RA, Wiffen PJ, Derry S, McQuay HJ This review updates parts of two earlier Cochrane reviews investigating effects of gabapentin in chronic neuropathic pain (pain due to nerve damage). Antiepileptic drugs are used to manage pain, predominantly for chronic neuropathic pain, especially when the pain is lancinating or burning. PMID: 21412914 [PubMed - in process] (Source: Cochrane Database of Systematic Reviews)

WITHDRAWN: Gabapentin for acute and chronic pain.

Authors: Wiffen PJ, McQuay HJ, Edwards J, Moore RA February 2009: The authors are aware of unpublished trial data for Gabapentin which could affect the results of this review. This information together with that from trials published since 2005, will be considered when this review is updated in 2009.Anticonvulsant drugs have been used in the management of pain since the 1960s. The clinical impression is that they are useful for chronic neuropathic pain, especially when the pain is lancinating or burning. PMID: 21412888 [PubMed - in process] (Source: Cochrane Database of Systematic Reviews)<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>

Gralise (Gabapentin Tablets) - updated on RxList

Gralise (Gabapentin Tablets) drug description - FDA approved labeling for prescription drugs and medications at RxList (Source: RxList - New and Updated Drug Monographs)

Efficacy of pregabalin in acute postoperative pain: a meta-analysis

Multimodal treatment of postoperative pain using adjuncts such as gabapentin is becoming more common. Pregabalin has anti-hyperalgesic properties similar to gabapentin. In this systematic review, we evaluated randomized, controlled trials (RCTs) for the analgesic efficacy and opioid-sparing effect of pregabalin in acute postoperative pain. A systematic search of Medline (1966&ndash;2010), the Cochrane Central Register of Controlled Trials (CENTRAL), and Google Scholar was performed. We identified 11 valid RCTs that used pregabalin for acute postoperative pain. Postoperative pain intensity was not reduced by pregabalin. Cumulative opioid consumption at 24 h was significantly decreased with pregabalin. At pregabalin doses of &lt;300 mg, there was a reduction of 8.8 mg [weighted mean differen...

Clonidine, SSRIs, SNRIs and gabapentin reduce hot flushes in women with a history of breast cancer; relaxation therapy may have a mild effect in the short term

(Source: Evidence-Based Nursing)

Management of provoked seizure

This article is a part of the Guidelines for Epilepsy in India. This article reviews the problem of provoked seizure and its management and also provides recommendations based on currently available information. Seizure provoked by metabolic disturbances requires correction of the triggering factors. Benzodiazepines are recommended for treatment of seizure due to alcohol withdrawal; gabapentin for seizure seen in porphyria; and antiepileptic drugs (AED), that are not inducer of hepatic enzymes, in the seizures seen in hepatic dysfunction. In severe traumatic brain injury, with or without seizure, phenytoin (PHT) may be given for 7 days. In ischemic or hemorrhagic stroke one may individualize the AED therapy. In cerebral venous sinus thrombosis (CVST), AED may be prescribed if there is seiz...

Treating children with attention-deficit/hyperactivity disorder and comorbid epilepsy

Shivanand Kattimani, S MahadevanAnnals of Indian Academy of Neurology 2011 14(1):9-11Attention-deficit/hyperactivity disorder (ADHD) is one of common neurodevelopmental disorder often comorbid with epilepsy. There are no existing guidelines on how to manage these two conditions when they are comorbid. To identify relationship between epilepsy and ADHD and to know role of antiepileptics and safety of stimulant like methylphenidate in such conditions from existing literature, we searched articles published in clinical journals available online between 1990-2010, with these key words in medline:children, epilepsy, seizure, comorbid, ADHD, treatment. Relevant abstracts were further selected for their focus on current topic. Cross references were extracted. Finally relevant articles that includ...<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>

Clinical Characteristics, Pharmacotherapy, and Healthcare Resource Use among Patients with Diabetic Neuropathy Newly Prescribed Pregabalin or Gabapentin

Conclusions:‚?? Patients with pDPN prescribed pregabalin and gabapentin had a substantial comorbidity and pain medication burden. Although healthcare costs increased in both groups, the increase in pain medication burden was higher in the gabapentin group. Direct medical costs were similar for both groups. Given the human and economic burden of pDPN, future research may benefit from a focus on efficacy parameters to further differentiate treatment options. (Source: Pain Practice)

NCSO March 2011

Source: PSNC (Pharmaceutical Services Negotiating Committee) Area: News The Department of Health has granted either the NCSO concession or a price concession for March 2011 to more Part VIII products, for March 2011 as follows: &nbsp; .&nbsp;Citalopram 20mg tablets .&nbsp;Cyclophosphamide 50mg tablets .&nbsp;Gabapentin 100mg capsules .&nbsp;Gabapentin 400mg capsules .&nbsp;Mebeverine 135mg tablets .&nbsp;Prednisolone 5mg tablets .&nbsp;Sertraline 100mg tablets &nbsp; For these products, no endorsement is needed; the concessionary price will be used in calculating reimbursement for all prescriptions submitted for pricing in March 2011. &nbsp; Please see link below for full details, and products not available at the Drug Tariff price. (Source: NeLM - News)

Evidence‚?źbased guideline: Treatment of painful diabetic neuropathy‚??report of the american association of neuromuscular and electrodiagnostic medicine, the american academy of neurology, and the american academy of physical medicine & rehabilitation

The objective of this report was to develop a scientifically sound and clinically relevant evidence‚?źbased guideline for the treatment of painful diabetic neuropathy (PDN). The basic question that was asked was: ‚??What is the efficacy of a given treatment (pharmacological: anticonvulsants, antidepressants, opioids, others; non‚?źpharmacological: electrical stimulation, magnetic field treatment, low‚?źintensity laser treatment, Reiki massage, others) to reduce pain and improve physical function and quality of life (QOL) in patients with PDN?‚?Ě A systematic review of literature from 1960 to August 2008 was performed, and studies were classified according to the American Academy of Neurology classification of evidence scheme for a therapeutic article. Recommendations were linked to the str...

The Effects of Intrathecal and Systemic Gabapentin on Spinal Substance P Release.

Conclusion: Systemic and spinal gabapentin have an acute inhibitory effect on the release of substance P from small primary afferents and a concurrent effect upon the initiation of facilitated pain states. PMID: 21385982 [PubMed - as supplied by publisher] (Source: Anesthesia and Analgesia)

Depomed Completes Enrollment of Breeze 3 Phase 3 Clinical Trial for Non-Hormonal Treatment in Menopausal Hot Flashes

MENLO PARK, Calif., March 3, 2011 (GLOBE NEWSWIRE) -- Depomed, Inc. (Nasdaq:DEPO) announced today that it has completed enrollment of Breeze 3, the company's pivotal Phase 3 clinical trial evaluating Serada(r) (extended release gabapentin tablets) for the non-hormonal treatment of menopausal hot flashes. (Source: Medical News (via PRIMEZONE))<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>

Evidence‚?źbased guideline: Treatment of painful diabetic neuropathy

The objective of this report was to develop a scientifically sound and clinically relevant evidence based guideline for the treatment of painful diabetic neuropathy (PDN). The basic question that was asked was ‚??What is the efficacy of a given treatment (pharmacological: anticonvulsants, antidepressants, opioids, others; and non‚?źpharmacological: electrical stimulation, magnetic field treatment, low‚?źintensity laser treatment, Reiki massage, others) to reduce pain and improve physical function and quality of life (QOL) in patients with PDN?‚?ĚA systematic review of literature from 1960 to August 2008 was performed and studies were classified according to the American Academy of Neurology classification of evidence scheme for a therapeutic article. Recommendations were linked to the stre...

Hi-Tech Pharmacal Receives Final Approval And 180 Day Market Exclusivity For Gabapentin Oral Solution

Hi-Tech Pharmacal Co., Inc. (NASDAQ: HITK), a specialty pharmaceuticals company, announced that the US Food and Drug Administration, (FDA) granted final approval for the Company's Abbreviated New Drug Application, (ANDA) for gabapentin oral solution 250mg/5mL, the generic for Pfizer's Neurontin¬ģ oral solution, which had sales of $15 million for the 12 months ended December 2010 according to IMS sales data. The product is indicated for postherpetic neuralgia and epilepsy... (Source: Health News from Medical News Today)

Use of Gabapentin for the Management of Natural or Surgical Menopausal Hot Flashes (March).

CONCLUSIONS: Gabapentin 600-2400 mg/day in divided doses may be a viable option for treating hot flashes in menopausal women who do not want to use hormone replacement therapy. PMID: 21343402 [PubMed - as supplied by publisher] (Source: The Annals of Pharmacotherapy)

THERAPENTIN-90 (Gabapentin, .Gamma.-Aminobutyric Acid) Kit [Physician Therapeutics LLC]

Updated Date: Feb 14, 2011 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

A comparative analysis of cetirizine, gabapentin and their combination in the relief of post-burn pruritus

Abstract: Post-burn pruritis is a very distressing symptom having a reported incidence between 80 and 100%. The mainstay of management of post-burn itch has been with antihistaminics and emollients but the treatment is ineffective in a very large percentage of patients. With the recognition of a distinct itch specific neuronal pathway, which has a complex interaction with pain pathway, a fresh approach to itch management has surfaced with the use of gabapentin. Gabapentin is an antiepileptic drug which has been successfully used to manage neuropathic pain, and is reporting to be successful in management of all forms of itch. With a paucity of randomized trials evaluating the role of gabapentin in post-burn itch management the current study was undertaken to individually evaluate gabapentin...<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>

Neuropathic pain during treatment for childhood acute lymphoblastic leukemia

ConclusionsOur results highlight the need for prospective randomized studies to elucidate the value of gabapentin regimen for prevention or treatment of vincristine‚?źrelated pain during treatment of childhood leukemia. Pediatr Blood Cancer ¬© 2011 Wiley‚?źLiss, Inc. (Source: Pediatric Blood and Cancer)

Wallenberg‚??s syndrome and symptomatic trigeminal neuralgia

Abstract&nbsp;&nbsp;Symptomatic trigeminal neuralgia due to a brainstem infarction is said to be rare. However, facial pain is not uncommon in Wallenberg‚??s syndrome. Facial pain related to a Wallenberg‚??s syndrome may be either persistent of intermittent, and occasionally occurs in brief attacks. Here, we report a patient with a right lateral medullary infarction who started having first division trigeminal neuralgia 1&nbsp;month after the stroke. The pain paroxysms were suppressed with gabapentin. Content Type Journal ArticlePages 1-4DOI 10.1007/s10194-011-0305-9Authors Carlos M. Ord√°s, Servicio de Neurolog√≠a, Hospital Cl√≠nico San Carlos, Universidad Complutense, Profesor Mart√≠n Lagos s/n, 28040 Madrid, SpainMar√≠a L. Cuadrado, Servicio de Neurolog√≠a, Hospital Cl√≠nico S...

Generic Shortages/NCSO February 2011 (updated 9th February)

Source: PSNC (Pharmaceutical Services Negotiating Committee) Area: News The Department of Health has granted the NCSO Concession or concessionary price increases to a number of Part VIII products for February 2011 as follows. &nbsp; Products granted the NCSO Concession for February 2011: &nbsp; .&nbsp;Gabapentin 400mg capsules .&nbsp;Mebeverine 135mg tablets .&nbsp;Moclobemide 300mg tablets .&nbsp;Naftidrofuryl 100mg capsules .&nbsp;Sertraline 100mg tablets &nbsp; To claim the NCSO concession, the prescription must be fully endorsed with the letters 'NCSO' and full details of the product dispensed. The endorsement must also be signed or initialed and dated. If any of this information is missing, payment will be based on the Drug Tariff price rather than the endorsed pr...

Cutaneous Nerve Transection for the Management of Intractable Upper Extremity Pain Caused By Invasive Squamous Cell Carcinoma

We present the case of an immunosuppressed patient post-lung transplant who was suffering from intractable pain caused by widely metastatic squamous cell carcinoma. The patient's progressive, excruciating neuropathic pain was localized to the area of the left wrist and forearm. Additionally, the patient complained of moderate pain at sites of tumor involvement on her right arm and scalp. Attempts to adequately manage her left upper extremity pain included a combination of pharmacologic treatments intended to treat neuropathic pain (gabapentin, SNRI, ketamine, opioids) and focused regional analgesia (infraclavicular infusion of local anesthetic). However, the patient developed intolerable side effects including altered mental status and delirium associated with the systemic agents and subop...

Acute Administration of Gabapentin Can Prevent Postherpetic Neuralgia

Gabapentin, given acutely, reduces the incidence of postherpetic neuralgia and might prevent episodes. Medscape Medical News (Source: Medscape Neurology and Neurosurgery Headlines)<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>

FDA Approves Once-Daily Gabapentin for Postherpetic Neuralgia

The manufacturer expects the drug to be available later this year. Medscape Medical News (Source: Medscape Infectious Diseases Headlines)

FDA approves gabapentin once-daily for post-herpetic neuralgia

FDA has approved gabapentin (Gralise, Depomed and Abbott Products) tablets for once-daily treatment of post-herpetic neuralgia. (Source: Drug Topics - Pharmacy News)

Optimal dose of pre‚?źincision/post‚?źincision gabapentin for pain relief following lumbar laminectomy: a randomized study

Conclusion: Gabapentin 900 or 1200‚??mg, administered either pre‚?ź or post‚?źincision, was found to be effective in pain management following lumbar laminectomy. Similar doses of gabapentin provide the same post‚?źoperative analgesia whether administered pre‚?ź or post‚?źincision. (Source: Acta Anaesthesiologica Scandinavica)

FDA approves gabapentin once-daily for post-herpetic neuralgia

FDA has approved gabapentin (Gralise, Depomed and Abbott Products) tablets for once-daily treatment of post-herpetic neuralgia. (Source: Modern Medicine)

A controlled trial of flumazenil and gabapentin for initial treatment of methylamphetamine dependence

Drug use has been associated with craving, which may be described as a powerful and sometimes overwhelming urge to use the drug. Patients seeking treatment for methylamphetamine dependence must cope with drug cravings as they engage in psychosocial treatments. Changes in brain GABAA receptors during substance use and withdrawal provide a neurobiological basis for craving and associated anxiety. Flumazenil (a benzodiazepine antagonist) plus gabapentin (an antiepileptic) were compared with placebo in a randomized, double-blind study to assess the effects on craving during initial treatment for methylamphetamine dependence. Evaluation was conducted over a 30-day period. Craving and drug use were found to be highly correlated. Craving was reduced significantly in the flumazenil plus gabapentin...

Cluster Headache‚??Acute and Prophylactic Therapy

(Headache 2011;51:272‚?ź286)Cluster headache (CH) pain is the most severe of the primary headache syndromes. It is characterized by periodic attacks of strictly unilateral pain associated with ipsilateral cranial autonomic symptoms. The majority of patients have episodic CH, with cluster periods that typically occur in a circannual rhythm, while 10% suffer from the chronic form, with no significant remissions between cluster periods. Sumatriptan injection or oxygen inhalation is the first‚?źline therapy for acute CH attacks, with the majority of patients responding to either treatment. The calcium channel blocker verapamil is the drug of choice for CH prevention. Other drugs that may be used for this purpose include lithium carbonate, topiramate, valproic acid, gabapentin, and baclofen. Tr...

Cluster headache-acute and prophylactic therapy.

Authors: Ashkenazi A, Schwedt T (Headache 2011;51:272-286) Cluster headache (CH) pain is the most severe of the primary headache syndromes. It is characterized by periodic attacks of strictly unilateral pain associated with ipsilateral cranial autonomic symptoms. The majority of patients have episodic CH, with cluster periods that typically occur in a circannual rhythm, while 10% suffer from the chronic form, with no significant remissions between cluster periods. Sumatriptan injection or oxygen inhalation is the first-line therapy for acute CH attacks, with the majority of patients responding to either treatment. The calcium channel blocker verapamil is the drug of choice for CH prevention. Other drugs that may be used for this purpose include lithium carbonate, topiramate, valproic a...<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>

Trigeminal trophic syndrome treated with thermoplastic occlusion.

Authors: Kurien AM, Damian DL, Moloney FJ A 72-year-old man with a history of thrombotic CVA causing lateral medullary infarction presented with non-healing ulcers of the right side of the face of 5‚??months' duration. After extensive investigations, a diagnosis of trigeminal trophic syndrome was made. The ulcers progressed relentlessly despite amitriptyline and gabapentin, and he was treated with a combination of carbamazepine and thermoplastic mask occlusion of the right side of his face. Over the next 10‚??weeks the shallower facial ulcers began to diminish in depth and diameter, and the deeper ulcers stopped progressing. Although the patient showed early signs of healing, he died because of complications from the CVA. PMID: 21332680 [PubMed - in process] (Source: The Australasi...

QD Gabapentin Wins FDA Nod for Shingles Pain

(MedPage Today) -- The FDA has approved a novel once-daily formulation of gabapentin (Gralise) for postherpetic neuralgia, although a corporate squabble could keep it out of patients' reach. (Source: MedPage Today Psychiatry)

Depomed Announces US Food and Drug Administration Approval of Gralise (gabapentin) Once-Daily Tablets for Treatment of Post-Herpetic Neuralgia

MENLO PARK, Calif., Jan 28, 2011 - --Depomed, Inc. today announced that US FDA has approved Gralise (gabapentin) Tablets for once-daily treatment of post-herpetic neuralgia (PHN), which is pain following healing of the rash associated with... (Source: Drugs.com - New Drug Approvals)

Rapid and validated fluorometric HPLC method for determination of gabapentin in human plasma and urine for clinical application

Conclusion:‚?? A rapid and validated isocratic fluorometric HPLC method for the determination of gabapentin in human plasma and urine for clinical application has been established. This method can be utilized to evaluate the pharmacokinetic disposition of gabapentin in humans. (Source: Journal of Clinical Pharmacy and Therapeutics)

Depomed Announces US Food and Drug Administration Approval of GRALISE(TM) (gabapentin) Once-Daily Tablets for Treatment of Post-Herpetic Neuralgia

MENLO PARK, Calif., Jan. 28, 2011 (GLOBE NEWSWIRE) -- Depomed, Inc. (Nasdaq:DEPO) today announced that US FDA has approved GRALISE(tm) (gabapentin) Tablets for once-daily treatment of post-herpetic neuralgia (PHN), which is pain following healing of the rash associated with shingles. GRALISE was developed by Depomed under the code name DM-1796 and is licensed to Abbott Products, Inc. in the U.S., Canada and Mexico. The approval of GRALISE triggers a milestone payment of $48 million from Abbott to Depomed. (Source: Medical News (via PRIMEZONE))<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>

[1-(Carboxymethyl)cyclohexyl]methanaminium nitrate

The title compound, C9H18NO2+¬∑NO3‚??, is an anhydrous nitrate salt of gabapentin, which is formed serendipitously in the presence of selected non-coordinating metals. The crystal structure involves extensive hydrogen bonding between the ‚??NH3+ and ‚??COOH groups and the nitrate anion. (Source: Acta Crystallographica Section E)

Predictors of catheter-related bladder discomfort in the post-anaesthesia care unit.

CONCLUSION: This observational study identified the incidence and predictive factors of moderate and severe CRBD in the PACU. Future studies are warranted to assess the impact of preoperative antimuscarinic drugs or Gabapentin on males or patients with 18 G Fr Foley catheters. PMID: 21277735 [PubMed - as supplied by publisher] (Source: Annales Francaises d'Anesthesie et de Reanimation)

Treatment of Diabetic Sensory Polyneuropathy

Opinion statement&nbsp;&nbsp;No current disease-modifying treatments have been shown definitively in randomized clinical trials to reduce or reverse diabetic sensory polyneuropathy (DSP). It is increasingly recognized that individuals with ‚??prediabetes‚?Ě or impaired glucose regulation can already have a ‚??small-fiber‚?Ě neuropathy, or mild DSP, in which sensory axons of both small and larger diameter are damaged. Small-fiber neuropathy is frequently associated with pain, and these patients may present to a neurologist for evaluation before the underlying glucose dysregulation has been diagnosed. It is important to identify these individuals, because aggressive diabetic control and lifestyle interventions can delay the onset of diabetes and may reverse small-fiber neuropathy associ...

[Pharmacological treatment of nystagmus.]

Authors: Pieh-Beisse C, Lagrèze WA Nystagmus can be associated with strong discomfort due to oscillopsia, blurry vision and dizziness. Since generally no curative treatment methods exist, studies focus on potential pharmaceuticals to dampen the nystagmus. An overview is given on which forms of nystagmus can be treated with what kind of pharmacological substances and their possible mechanism of nystagmus dampening. Controlled studies found gabapentin and memantine to be effective in acquired pendular nystagmus and early-onset idiopathic nystagmus, and an efficacy of 4-aminopyridine in downbeat nystagmus. PMID: 21253746 [PubMed - as supplied by publisher] (Source: Der Ophthalmologe)

Quiz Page February 2011: Acute Kidney Injury, Graft Pain, and Subtherapeutic Levels of Tacrolimus

A 46-year-old Hispanic woman with end-stage renal disease due to chronic glomerulonephritis and chronic rejection of her first kidney transplant received a second kidney transplant in June 2008. Allograft function had been stable, with a serum creatinine level in the range of 1.1-1.2 mg/dL (97-106 őľmol/L; estimated glomerular filtration rate [eGFR], 57-51 mL/min/1.73 m2 [1.61-0.95 mL/s/1.73 m2] calculated using the 4-variable MDRD [Modification of Diet in Renal Disease] Study equation). She had been on maintenance immunosuppression therapy with mycophenolate mofetil (MMF), 750 mg, twice daily and tacrolimus, 1 mg, twice daily. Eighteen months after transplant, she developed acute kidney injury (AKI) with persistent diarrhea, 15-lb weight loss, and increased tacrolimus level (13.4 ng/mL). ...<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>

Oral gabapentin for photorefractive keratectomy pain

Conclusion: When added to a standardized postoperative pain regimen, gabapentin use led to no additional improvement in PRK pain control compared with a placebo at the dose and the time intervals tested.Financial Disclosure: No author has a financial or proprietary interest in any material or method mentioned. (Source: Journal of Cataract and Refractive Surgery)

Antiepileptic drugs interact with folate and vitamin B12 serum levels

AbstractObjective:Antiepileptic drugs (AEDs) are important for the treatment of epilepsy, psychiatric diseases, and pain syndromes. Small studies have suggested that AED treatment reduces serum levels of folate and vitamin B12.Methods:This prospective monocenter study aimed at testing the hypothesis that AED treatment is associated with folate and vitamin B12 serum levels in a large population. A total of 2730 AED‚?źtreated and 170 untreated patients with epilepsy and 200 healthy individuals were enrolled.Results:Treatment with carbamazepine, gabapentin, oxcarbazepine, phenytoin, primidone, or valproate was associated with lower mean serum folate levels or with a higher frequency of folate levels below the reference range in comparison with the entire group of patients, untreated patients,...

Depomed Will Engage in Mediation to Resolve Dispute With Abbott; Comments on DM-1796 Regulatory Status and Orphan Drug Designation

MENLO PARK, Calif., Jan. 18, 2011 (GLOBE NEWSWIRE) -- Depomed, Inc. (Nasdaq:DEPO) today announced that it will engage in a mediation process with Abbott Products, Inc., regarding Abbott's commercialization obligations related to DM-1796, an investigational, once-daily formulation of gabapentin for the management of post-herpetic neuralgia (PHN). DM-1796 was developed by Depomed and is licensed to Abbott Products in the U.S., Canada and Mexico for the treatment of pain. (Source: Medical News (via PRIMEZONE))

The Effect of Lamotrigine on Valproic Acid Concentrations.

Conclusions: Although there is a wide variation in the changes of valproic acid concentrations when lamotrigine is added, the concentrations tend to increase rather than decrease, especially with low or intermediate initial valproic acid concentrations. In some cases valproate toxicity, manifested by abnormal bruising, may result, although at higher initial valproic acid concentrations the valproic acid concentration usually tends to fall slightly with the addition of lamotrigine. PMID: 21241246 [PubMed - as supplied by publisher] (Source: Current Drug Safety)

Calcium channel alpha-2-delta-1 protein upregulation in dorsal spinal cord mediates spinal cord injury-induced neuropathic pain states

Abstract: Spinal cord injury (SCI) commonly results in the development of neuropathic pain, which can dramatically impair the quality of life for SCI patients. SCI-induced neuropathic pain can be manifested as both tactile allodynia (a painful sensation to a non-noxious stimulus) and hyperalgesia (an enhanced sensation to a painful stimulus). The mechanisms underlying these pain states are poorly understood. Clinical studies have shown that gabapentin, a drug that binds to the voltage-gated calcium channel alpha-2-delta-1 subunit (CavőĪ2őī-1) proteins is effective in the management of SCI-induced neuropathic pain. Accordingly, we hypothesized that tactile allodynia post SCI is mediated by an upregulation of CavőĪ2őī-1 in dorsal spinal cord. To test this hypothesis, we examined whether SCI-...<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>

The Effects of Gabapentin on Acute and Chronic Postoperative Pain After Coronary Artery Bypass Graft Surgery

Conclusions: Gabapentin significantly reduced the intensity of pain and tramadol consumption in the early postoperative period after CABG surgery. Pain scores at 1 and 3 months after surgery were low in both groups, with no significant difference between the groups. (Source: Journal of Cardiothoracic and Vascular Anesthesia)

NCSO status January 2011

Source: PSNC (Pharmaceutical Services Negotiating Committee) Area: News NCSO (no cheaper stock obtainable status) is granted for January 2010 for the following products: &nbsp; .&nbsp;Cabergoline 1mg tablets .&nbsp;Citalopram 40mg tablets .&nbsp;Gabapentin 400mg capsules .&nbsp;Oxybutynin 3mg tablets .&nbsp;Tamoxifen 20mg tablets .&nbsp;Trazadone 50mg/5ml oral solution S/F &nbsp; When claiming NCSO it is essential that contractors endorse the prescription with the letters 'NCSO' and full details of the product dispensed (e.g. manufacturer, brand name or price if it is an uncommon item and pack size). The endorsement must also be signed or initialled and dated. If any of this information is missing, payment will be based on the Drug Tariff price rather than the endorsed pro...

Association of Antiepileptic Drugs With Nontraumatic Fractures: A Population-Based Analysis [Original Contribution]

Conclusions&nbsp; Most AEDs were associated with an increased risk of nontraumatic fractures in individuals aged 50 years or older. Further studies are warranted to assess the risk of nontraumatic fractures with the newer AEDs and to determine the efficacy of osteoprotective medications in this population. (Source: Archives of Neurology)

Is There a Recreational Misuse Potential for Pregabalin? Analysis of Anecdotal Online Reports in Comparison with Related Gabapentin and Clonazepam Data

Psychother Psychosom 2011;80:118‚??122 (DOI:10.1159/000321079) (Source: Karger Publishers)

Is There a Recreational Misuse Potential for Pregabalin Analysis of Anecdotal Online Reports in Comparison with Related Gabapentin and Clonazepam Data

Psychother Psychosom 2011;80:118‚??122 (DOI:10.1159/000321079) (Source: Psychotherapy and Psychosomatics)<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>

[Analgesic prescription habits in a population of patients with chronic rheumatic disease.]

Conclusions: There was a discrepancy between the prescription and the current indications of WHO for the control of chronic pain. This discrepancy raises the possibility of failure of some pharmacological agents in this type of pain and/or lack of systematization of analgesic therapy. We recommend further studies to prove the hypothesis. PMID: 21672442 [PubMed - as supplied by publisher] (Source: Acta Medica Portuguesa)

Phantom restless legs syndrome in a patient with unilateral above knee amputation

Various sensory phenomena have been described following amputation of a limb in what is called the phantom limb. Commonly, they are divided into two main groups: phantom pain and nonpainful sensations, each occurring in about 50‚??80% of patients after amputation . In addition, two-thirds of amputees complain of sleep onset and maintenance insomnia; in those who suffer from phantom pain the percentage increases to 80 . A 54-year-old man who had an above knee amputation of his left lower leg 15years ago due to a leiomyosarcoma presented with typical restless legs symptoms that started 3years ago. He reported unpleasant sensations accompanied by an urge to move in the evening and at night during periods of inactivity. First only the amputated left lower leg was affected, and symptoms improve...

A Meta‚?źAnalysis of Pain Response in the Treatment of Fibromyalgia

Conclusion:‚?? All eight active treatments displayed evidence suggesting improvement over placebo in the treatment of pain in patients suffering from fibromyalgia. Indirect comparison of active treatments found no strong differences. (Source: Pain Practice)

Solubilization of Gabapentin into HII Mesophases

The Journal of Physical Chemistry BDOI: 10.1021/jp108801d (Source: Journal of Physical Chemistry B)

Penicillamine: Status dystonicus treated with gabapentin: 3 case reports

(Source: Reactions)<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>

Effects of gabapentin on brain hyperactivity related to pain and sleep disturbance under a neuropathic pain‚?źlike state using fMRI and brain wave analysis

AbstractNeuropathic pain is the most difficult pain to manage in the pain clinic, and sleep problems are common among patients with chronic pain including neuropathic pain. In the present study, we tried to visualize the intensity of pain by assessing neuronal activity and investigated sleep disturbance under a neuropathic pain‚?źlike state in mice using functional magnetic resonance imaging (fMRI) and electrocardiogram (EEG)/ electromyogram (EMG), respectively. Furthermore, we investigated the effect of gabapentin (GBP) on these phenomena. In a model of neuropathic pain, sciatic nerve ligation caused a marked decrease in the latency of paw withdrawal in response to a thermal stimulus only on the ipsilateral side. Under this condition, fMRI showed that sciatic nerve ligation produced a sig...

Which medication do I need to manage dizzy patients?

Authors: Huppert D, Strupp M, M√ľckter H, Brandt T Abstract Vertigo and dizziness are not independent disease entities, but instead symptoms of various diseases. Accordingly, a variety of treatment approaches are required. Here we review the most relevant drugs for managing dizziness, vertigo, and nystagmus syndromes. It is important to differentiate symptomatic treatment of nausea and vomiting with, for example, dimenhydrinate and benzodiazepines, and prophylactic treatment of motion sickness with scopolamine from a causal therapy of the underlying disorders. Examples of such causal therapy include aminopyridines for downbeat nystagmus and episodic ataxia type 2; carbamazepine for vestibular paroxysmia, paroxsymal dysarthria and ataxia in multiple sclerosis, and superior oblique myoky...

Systematic Review of the Comparative Effectiveness of Antiepileptic Drugs for Fibromyalgia

Conclusions from this paper can help clinicians to more effectively treat the pain associated with fibromyalgia. (Source: The Journal of Pain)

Gabapentin for the treatment of carpal tunnel syndrome: a randomized controlled trial

Conclusions:‚?? Gabapentin did not produce a significant reduction in symptom severity compared with placebo over an eight‚?źweek period. (Source: European Journal of Neurology)

Multicenter, Randomized, Cross-Over Clinical Trial of Venlafaxine Versus Gabapentin for the Management of Hot Flashes in Breast Cancer Survivors [Breast Cancer]

Conclusion Breast cancer survivors prefer venlafaxine over gabapentin for treating hot flashes. (Source: Journal of Clinical Oncology)<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>

HZ166, a novel GABA(A) receptor subtype-selective benzodiazepine site ligand, is antihyperalgesic in mouse models of inflammatory and neuropathic pain.

Authors: Di Lio A, Benke D, Besson M, Desmeules J, Daali Y, Wang ZJ, Edw.ar R, Cook JM, Zeilhofer HU Diminished GABAergic and glycinergic inhibition in the spinal dorsal horn contributes significantly to chronic pain of different origins. Accordingly, pharmacological facilitation of GABAergic inhibition by spinal benzodiazepines (BDZs) has been shown to reverse pathological pain in animals as well as in human patients. Previous studies in GABA(A) receptor point-mutated mice have demonstrated that the spinal anti-hyperalgesic effect of classical BDZs is mainly mediated by GABA(A) receptors containing the őĪ2 subunit (őĪ2-GABA(A) receptors), while őĪ1-GABA(A) receptors, which mediate the sedative effects, do not contribute. Here, we investigated the potential analgesic profile of HZ166, ...

BREEZE 2: Gabapentin-ER Tames Hot Flashes

Major Finding: Gabapentin-ER 1,800 mg/day may be effective and well tolerated for the treatment of moderate to severe hot flashes in postmenopausal women. (Source: Ob.Gyn. News)

Molecular basis for the dosing time-dependency of anti-allodynic effects of gabapentin in a mouse model of neuropathic pain

Conclusions: These findings suggest that the dosing time-dependent difference in the anti-allodynic effects of gabapentin is attributable to the circadian oscillation of alpha2delta-1 subunit expression in the DRG and indicate that the optimizing its dosing schedule helps to achieve rational pharmacotherapy for neuropathic pain. (Source: BioMed Central)

Neuropathy in diabetes

Abstract: Diabetic polyneuropathy is one of the commonest long-term complications of diabetes and the commonest form of neuropathy in the developed world. It encompasses a number of neuropathic syndromes, the commonest of which is chronic distal symmetrical polyneuropathy, also known as diabetic peripheral neuropathy (DPN). DPN is a cause of considerable morbidity, including foot ulceration, amputations and neuropathic pain, and is associated with cardiovascular disease and increased mortality. Risk factors for DPN include poor glucose control and markers of macrovascular disease, such as hypertension. There is now strong evidence implicating nerve ischaemia as the cause. Painful DPN affects 15‚??26% of all people with diabetes and can lead to considerable disability. The assessment and ma...

Prognostic assessments of medical therapy and vestibular testing in post-traumatic migraine-associated dizziness patients

Conclusion: Specific prophylactic antimigraine medications were not associated with improved outcomes in PTMAD patients. Initial clinical responses and vestibular test metrics may guide physicians to predict successful outcomes. (Source: Otolaryngology - Head and Neck Surgery)<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>

Prevalence of gabapentin in impaired driving cases in Washington State in 2003-2007. - Peterson BL.

Gabapentin (Neurontin) is an antiepileptic drug commonly prescribed for pain treatment. In the past 15 years, indications for gabapentin have been increasing even though the complete mechanism of action is unknown. Side effects include somnolence, dizzines... (Source: SafetyLit: All (Unduplicated))

Update on Chronic Daily Headache

Opinion statement&nbsp;&nbsp;Chronic daily headache (CDH), defined as a primary headache occurring at least 15&nbsp;days per month, is a problem of worldwide scope, which is seen in 3% to 5% of the population. Though it has been recognized since ancient times, only recently have there been attempts to define and classify it. CDH usually consists of a mixture of migraine and tension-type headaches (TTH), with the more severe headaches having migraine features and the less severe headaches fitting the definition of TTH. Some patients have pure chronic TTH and no migrainous features, and others have only migraine, but most have a mixed migraine-TTH pattern. New daily persistent headache, a CDH pattern that comes on over a few days, constitutes 9% to 10% of this group and is otherwise in...

Cocrystallization of C-butyl pyrogallol[4]arene and C-propan-3-ol pyrogallol[4]arene with gabapentin

Drew A. Fowler, Jian Tian, Charles Barnes, Simon J. Teat, Jerry L. Atwood (Paper from CrystEngComm) Drew A. Fowler, CrystEngComm, 2011, DOI: 10.1039/c0ce00661k To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - CrystEngComm latest articles)

Synthesis and biological activities of Schiff bases of gabapentin with different aldehydes and ketones: a structure‚??activity relationship study

Abstract&nbsp;&nbsp;A series of novel gabapentin derivatives 6a‚??k and 7a‚??f were synthesized, and their biological activities were determined. The chemical structures were confirmed by elemental analyses, UV‚??visible, FT-IR, and 1H NMR spectral studies. The structure‚??activity relationships (SAR) for anticonvulsant and antioxidant activities were discussed. Compounds 7a‚??f were evaluated for their possible anticonvulsant activity by Maximal Electroshock Seizure (MES) test, and their neurotoxic effects were determined by rotorod test. Majority of the compounds were active in MES tests. Compounds 7b and 7e showed good protective effect from seizure when compared to standard drug, phenytoin (100&nbsp;mg/kg). The same compounds showed no neurotoxicity at the maximum dose administered...

Gabapentin Improves Postcesarean Delivery Pain Management: A Randomized, Placebo-Controlled Trial.

Conclusion: Preoperative gabapentin 600 mg in the setting of multimodal analgesia reduces postcesarean delivery pain and increases maternal satisfaction in comparison with placebo. PMID: 21081764 [PubMed - as supplied by publisher] (Source: Anesthesia and Analgesia)<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>

BREEZE 2: Gabapentin-ER Tamed Hot Flashes

Major Finding: Gabapentin-ER 1,800 mg/day may be effective and well tolerated for the treatment of moderate to severe hot flashes in postmenopausal women. (Source: Family Practice News)

Antiepileptic drug therapy the story so far

Abstract: The story began on 11th May 1857 when Charles Locock commented in the Lancet on his use of potassium bromide in 15 cases of ‚??hysterical‚?Ě epilepsy in young women. The next development was the serendipitous discovery of the anticonvulsant properties of phenobarbital by Alfred Hauptmann in 1912. This predated by more than 20 years the screening of potential therapeutic agents against ‚??electrical seizures‚?Ě in cats by Houston Merritt and Tracy Putnam. The result was the launching of phenytoin in 1938. Next came primidone, ethosuximide, carbamazepine and valproic acid, all of which can be regarded as first generation antiepileptic drugs (AEDs). Shortly after their synthesis, the benzodiazepines were rapidly recognised as having anticonvulsant activity. The modern era focused on...

Breast cancer survivors prefer venlafaxine for treatment of hot flashes

Women who have survived breast cancer prefer venlafaxine to gabapentin for the treatment of hot flashes, even though the two treatments are equally effective, study findings indicate. (Source: MedWire News - Breast Cancer)

Venlafaxine preferred over gabapentin for the management of hot flushes in breast cancer survivors?

Source: JCO Area: News According to the results of this open-label crossover study, breast cancer survivors prefer venlafaxine over gabapentin for the treatment of hot flushes. &nbsp; The authors note that hot flushes and other menopausal symptoms are reported often by women with breast cancer.&nbsp; In such patients these symptoms tend to be more severe and distressing, and of a greater duration - this could be due to a number of reasons, for example age at diagnosis, the abrupt discontinuation of HRT at the time of diagnosis, the induction of premature menopause with breast cancer treatment (e.g. chemotherapy), or induction of symptoms due to treatment (e.g. tamoxifen).&nbsp; Several interventions for hot flushes have been tried; the newer antidepressants (SSRI/SNRI) and gabapentin ...<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>

Venlafaxine Preferred Over Gabapentin for Hot Flashes

Breast cancer survivors may prefer venlafaxine for treating hot flashes over gabapentin, according to research published online Nov. 8 in the Journal of Clinical Oncology. (Source: Modern Medicine)

NEURONTIN (Gabapentin) Capsule [STAT RX USA LLC]

Updated Date: Nov 8, 2010 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

GABAPENTIN Capsule [Lake Erie Medical DBA Quality Care Products LLC]

Updated Date: Nov 5, 2010 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

Inhibition of recombinant N-type and native high voltage-gated neuronal Ca(2+) channels by AdGABA: Mechanism of action studies.

Authors: Mart√≠nez-Hern√°ndez E, Sandoval A, Gonz√°lez-Ram√≠rez R, Zoidis G, Felix R High-voltage activated Ca(2+) (Ca(V)) channels play a key role in the regulation of numerous physiological events by causing transient changes in the intracellular Ca(2+) concentration. These channels consist of a pore-forming Ca(V)őĪ(1) protein and three auxiliary subunits (Ca(V)ő≤, Ca(V)őĪ(2)őī and Ca(V)ő≥). Ca(V)őĪ(2)őī is an important component of Ca(V) channels in many tissues and of great interest as a drug target. It is well known that anticonvulsant agent gabapentin (GBP) binds to Ca(V)őĪ(2)őī and reduces Ca(2+) currents by modulating the expression and/or function of the Ca(V)őĪ(1) subunit. Recently, we showed that an adamantane derivative of GBP, AdGABA, has also inhibitory effects on Ca(V) c...

Variation in Antiepileptic Drug Adherence Among Older Patients with New-Onset Epilepsy (December).

CONCLUSIONS: Adherence difficulty in this elderly cohort is attributable to several factors, yet specific AEDs substantially increased this risk. Drugs that produce adverse effects such as cognitive difficulty or weight gain may prove detrimental to maintaining appropriate adherence early in the treatment course. Given comparable efficacy among AEDs, providers should be aware that certain medications impart differential risks of poor adherence in older patients with epilepsy. PMID: 21045168 [PubMed - as supplied by publisher] (Source: The Annals of Pharmacotherapy)<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>

Pregabalin versus gabapentin in partial epilepsy: a meta-analysis of dose-response relationships

Conclusion: In patients with refractory partial epilepsy, pregabalin is likely to be more effective than gabapentin at comparable effective doses, based on clinical response and the number of SFD. (Source: BMC Neurology)

Treatment of neuropathic itch possibly due to trigeminal trophic syndrome with 0.1% topical tacrolimus and gabapentin.

Authors: Nakamizu S, Miyachi Y, Kabashima K PMID: 21057761 [PubMed - in process] (Source: Acta Dermato-Venereologica)

Amisulpride‚?źInduced Seizurogenic Effect: A Potential Role of Opioid Receptor‚?źLinked Transduction Systems

AbstractThe present study was designed to investigate the role of opioid receptors, gamma‚?źaminobutyric acid (GABA) receptors, mast cells and histamine receptors (H1 subtype) in the seizurogenic effect of amisulpride on mice. A single injection of amisulpride (180 mg kg‚??1) was employed to evaluate the seizurogenicity of the drug in mice. Seizures were assessed in terms of a composite seizure severity score, time of the onset of straub‚?źlike tail, onset of jerky movements of whole body, convulsions and death. Amisulpride administration (180 mg kg ‚??1) induced a significant pro‚?źconvulsant effect in mice as measured in terms of the seizure severity score (21.12 ¬Ī 2.71) and a significant decrease in the time latency of the onset of straub‚?źlike tail (132.45 ¬Ī 12.31), jerky movements ...

An Open‚?źLabel Comparison of Nabilone and Gabapentin as Adjuvant Therapy or Monotherapy in the Management of Neuropathic Pain in Patients with Peripheral Neuropathy

AbstractNeuropathic pain (NeP) is prevalent in patients with peripheral neuropathy (PN), regardless of etiology. We sought to compare the efficacy of the cannabinoid nabilone as either monotherapy or adjuvant therapy with a first‚?źline medication for NeP, gabapentin, in a patient population with PN‚?źNeP. Patients diagnosed with PN‚?źNeP were permitted to initiate monotherapy (nabilone or gabapentin) or add one of these two medications (adjuvant therapy) to their existing NeP treatment regimen in a non‚?źrandomized open‚?źlabel nature. Baseline data collected included a primary outcome (visual analog scores [VAS] of pain) and secondary outcomes (quality of life [EuroQol 5 Domains and Short‚?źForm 36] assessments and assessments of sleep [Medical Outcomes Sleep Study Scale {MOSSS}], anxiet...

Fewer, Milder Hot Flashes With Gabapentin-ER

CHICAGO ‚?? An extended-release formulation of gabapentin for hot flashes showed the potential both to minimize peak adverse events and to allow for less frequent dosing in a randomized, controlled trial of 565 women. (Source: Clinical Endocrinology News)<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>

NEURONTIN (Gabapentin) Capsule NEURONTIN (Gabapentin) Tablet, Film Coated NEURONTIN (Gabapentin) Solution [Parke-Davis Div Of Pfizer Inc]

Updated Date: Oct 28, 2010 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

Gabapentin as a rescue drug in D-penicillamine-induced status dystonicus in patients with Wilson disease

We present three patients with Wilson disease who developed severe paroxysmal dystonic spells after receiving D-penicillamine treatment. All three patients responded well to gabapentin after failing to respond to other anti dystonia drugs. (Source: Neurology India)

New users of the anticonvulsants gabapentin, lamotrigine, oxcarbazepine or tiagabine are at increased risk of suicidal acts compared with new users of topiramate

(No abstract is available for this citation) (Source: Evidence-Based Mental Health)

A novel rat forelimb model of neuropathic pain produced by partial injury of the median and ulnar nerves

Abstract: The vast majority of human peripheral nerve injuries occur in the upper limb, whereas the most animal studies have been conducted using the hindlimb models of neuropathic pain, involving damages of the sciatic or lumbar spinal nerve(s). We attempted to develop a rat forelimb model of peripheral neuropathy by partial injury of the median and ulnar nerves. The halves of each nerve were transected by microscissors at about 5mm proximal from the elbow joint and behavioral signs of neuropathic pain, such as mechanical and cold allodynia, and heat hyperalgesia, were monitored up to 126days following nerve injury. Mechanical allodynia was assessed by measuring the forepaw withdrawal threshold to von Frey filaments, and cold allodynia was evaluated by measuring the time spent in lifting ...

Is duloxetine useful for central neuropathic pain?

Neuropathic pain is often classified according to the anatomic location (e.g. central versus peripheral) and underlying disease (stroke, painful diabetic polyneuropathy, etc.). Central pain may be a serious consequence of injuries or diseases affecting the central nervous system, occurring in up to 50% of patients following spinal cord injury, in 25% of patients with multiple sclerosis, and in 10% following stroke. There is a widespread belief that central pain is particularly difficult to treat. Despite this belief, except for topical treatments, drugs that are recommended for peripheral neuropathic pain, including tricyclic antidepressants, gabapentin, pregabalin, and opioids, are also effective in central pain, with similar effect sizes . Since treatment options are limited, and only fe...<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>

Role of Spinal Neurotransmitter Receptors in Itch: New Insights into Therapies and Drug Development.

Authors: Cevikbas F, Steinhoff M, Ikoma A Targets for antipruritic therapies are now expanding from the skin to the central nervous system. Recent studies demonstrate that various neuronal receptors in the spinal cord are involved in pruritus. The spinal opioid receptor is one of the best-known examples. Spinal administration of morphine is frequently accompanied by segmental pruritus. In addition to őľ-opioid receptor antagonists, őļ-opioid receptor agonists have recently come into usage as novel antipruritic drugs, and are expected to suppress certain subtypes of itch such as hemodialysis- and cholestasis-associated itch that are difficult to treat with antihistamines. The gastrin-releasing peptide receptor in the superficial dorsal horn of the spinal cord has also received recent at...

Gabapentin withdrawal: Drug withdrawal symptoms: case report

(Source: Reactions)

Postherpetic neuralgia

New option(s) added for: Herpes zoster vaccines for prevention herpes zoster and subsequent postherpetic neuralgia: We found two RCTs comparing herpes zoster vaccines versus placebo or no treatment. The first RCT found that zoster vaccine reduced the number of confirmed cases of herpes zoster at a mean follow-up time of 3.12 years, and reduced the incidence of herpes zoster per 1000 person-years. It found that zoster vaccine reduced the herpes zoster burden of illness at a mean of 3.12 years. The RCT also found that zoster vaccine reduced the number of cases of postherpetic neuralgia at a mean follow-up time of 3.12 years, and decreased the incidence of postherpetic neuralgia per 1000 person-years. The second RCT only reported harms; it found that advers...

Seizure and Pain Drug May Treat Hot Flashes

An extended-release version of the seizure and pain drug gabapentin may be one step closer to becoming the first approved nonhormonal treatment for menopause-related hot flashes. (Source: WebMD Health)

Gabapentin vs pregabalin: costs considered equal

(Source: PharmacoEconomics and Outcomes News)<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>

Cross-reactivity of skin rashes with current antiepileptic drugs in Chinese population

We described the clinical characteristics of the 18 patients with cross-reactivity involving the AEDs, and the cross- reactivity pattern for CBZ, PHT, OXC, and LTG.Results: A total of 3.61% (137/3793) of patients experienced a skin rash to at least one AEDs, of these patients, 73 (53.28%) were female and 64 were males (46.72%). While 18 patients had a rash to two or more AEDs. Of patients who had a rash to CBZ and were also prescribed PHT (n=17), 52.9% had a rash to PHT (abbreviated as CBZ‚??PHT: 52.9%); of patients who had a rash to PHT and were also prescribed CBZ (n=13), rate of rash was 69.2% (i.e., PHT‚??CBZ: 69.2%). Other results: CBZ‚??LTG: 25% (n=16); LTG ‚??CBZ: 44.4% (n=9); CBZ‚??OXC: 40% (n=10); OXC‚??CBZ: 66.7% (n=6); LTG‚??PHT: 20% (n=5); PHT‚??LTG: 16.7% (n=6); OXC‚??LTG: 25%...

Potentially Inappropriate Prescribing of Primarily Renally Cleared Medications for Older Veterans Affairs Nursing Home Patients

Conclusions: Potentially inappropriate prescribing of renally cleared medications is common in older VA NH patients. Intervention studies to improve the prescribing of primarily renally cleared medications in nursing homes are needed. (Source: Journal of the American Medical Directors Association)

Low dose of donepezil improves gabapentin analgesia in the rat spared nerve injury model of neuropathic pain: single and multiple dosing studies

In conclusion, the results from this preclinical study support the use of donepezil as adjunctive to gabapentin to improve the therapeutic outcome in the management of neuropathic pain. Content Type Journal ArticleDOI 10.1007/s00702-010-0494-4Authors Anna Folkesson, Department of Pharmacology and Pharmacotherapy, Faculty of Pharmaceutical Sciences, University of Copenhagen, Universitetsparken 2, 2100 Copenhagen, DenmarkPer Hartvig Honoré, Department of Pharmacology and Pharmacotherapy, Faculty of Pharmaceutical Sciences, University of Copenhagen, Universitetsparken 2, 2100 Copenhagen, DenmarkLene Munkholm Andersen, Department of Pharmacology and Pharmacotherapy, Faculty of Pharmaceutical Sciences, University of Copenhagen, Universitetsparken 2, 2100 Copenhagen, DenmarkPernille Kri...

Counseling patients about hormone therapy and alternatives for menopausal symptoms.

Authors: Hill DA, Hill SR The results of recent large clinical trials have led physicians and patients to question the safety of menopausal hormone therapy. In the past, physicians prescribed hormone therapy in an attempt to improve overall health and prevent cardiac disease. Hormone therapy appears to increase the risk of breast cancer when used for more than three to five years; therefore, regulatory agencies now advise that physicians prescribe it only to treat menopausal symptoms such as hot flashes and vaginal atrophy, with the smallest effective dosage and for the shortest possible duration. Although estrogen is the most effective treatment for hot flashes, alternatives such as venlafaxine and gabapentin are effective for some patients. Herbal formulations such as dong quai, gins...

Beneficial response to gabapentin portraying with interval change of brain SPECT imaging in a case with failed back surgery syndrome

Summary (Source: Journal of Clinical Pharmacy and Therapeutics)<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>

Analgesic efficacy of oral gabapentin added to standard epidural corticosteroids in patients with failed back surgery

Beyazit Zencirci (Source: International Journal of COPD)

THERAPENTIN-90 (Gabapentin) Capsule [Physician Therapeutics LLC]

Updated Date: Sep 30, 2010 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

Poster 44: Effectiveness of Gabapentinoids in Decreasing Neuropathic Pain Intensity Postspinal Cord Injury: A Meta-Analysis

Conclusions: The results of the meta-analysis demonstrate that treatment with gabapentinoids is associated with reduction in intensity of neuropathic pain post-SCI. (Source: Archives of Physical Medicine and Rehabilitation)

The association between antiepileptic drug and HMG-CoA reductase inhibitor co-medication and cholesterol management in patients with epilepsy

This study suggests that concomitant use of EIAEDs and statins may be associated with reduced clinical effectiveness of statins. Patients with epilepsy who use EIAEDs and statins concomitantly may require greater vigilance for optimal cholesterol management. (Source: Epilepsy Research)

Review of therapeutic agents for burns pruritus and protocols for management in adult and paediatric patients using the GRADE classification

Ioannis Goutos, Maria Clarke, Clara Upson, Patricia M Richardson, Sudip J GhoshIndian Journal of Plastic Surgery 2010 43(3):51-62To review the current evidence on therapeutic agents for burns pruritus and use the Grading of Recommendations, Assessment, Development and Evaluation (GRADE) classification to propose therapeutic protocols for adult and paediatric patients. All published interventions for burns pruritus were analysed by a multidisciplinary panel of burns specialists following the GRADE classification to rate individual agents. Following the collation of results and panel discussion, consensus protocols are presented. Twenty-three studies appraising therapeutic agents in the burns literature were identified. The majority of these studies (16 out of 23) are of an observational nat...<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>

GABAPENTIN Capsule [Lake Erie Medical DBA Quality Care Products LLC]

Updated Date: Sep 28, 2010 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

Once-Daily Gabapentin Effective for Postherpetic Neuralgia Pain and Sleep Disturbance

Extended-release gabapentin, 1800 mg once daily, is well tolerated and effective for pain relief and sleep improvement in patients with postherpetic neuralgia. Medscape Medical News (Source: Medscape Neurology and Neurosurgery Headlines)

Review of therapeutic agents for burns pruritus and protocols for management in adult and paediatric patients using the GRADE classification

Ioannis Goutos, Maria Clarke, Clara Upson, Patricia M Richardson, Sudip J GhoshIndian Journal of Plastic Surgery 2010 43(3):51-62To review the current evidence on therapeutic agents for burns pruritus and use the Grading of Recommendations, Assessment, Development and Evaluation (GRADE) classification to propose therapeutic protocols for adult and paediatric patients. All published interventions for burns pruritus were analysed by a multidisciplinary panel of burns specialists following the GRADE classification to rate individual agents. Following the collation of results and panel discussion, consensus protocols are presented. Twenty-three studies appraising therapeutic agents in the burns literature were identified. The majority of these studies (16 out of 23) are of an observational nat...

Vasomotor Symptoms: Viewpoint from the Indian Subcontinent and Management of a Common Menopausal Problem

This article reviews the symptoms and relates that VMS are of significant concern for the aging Asian women.[...]© Thieme Medical PublishersArticle in Thieme eJournals:Table of contents  |  Abstract  |  Full text (Source: Seminars in Reproductive Medicine)

Gabapentin as part of multimodal analgesia in a newborn with epidermolysis bullosa.

Authors: Allegaert K, Naulaers G PMID: 20849513 [PubMed - in process] (Source: Paediatric Anaesthesia)<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>

Gabapentin as part of multimodal analgesia in a newborn with epidermolysis bullosa

(Source: Pediatric Anesthesia)

Gabapentin withdrawal: Confusion: case report

(Source: Reactions)

Non-hormonal interventions for hot flushes in women with a history of breast cancer.

CONCLUSIONS: Clonidine, SSRIs and SNRIs, gabapentin and relaxation therapy showed a mild to moderate effect on reducing hot flushes in women with a history of breast cancer. PMID: 20824841 [PubMed - in process] (Source: Cochrane Database of Systematic Reviews)

A Comparison of the Pharmacokinetics and Pharmacodynamics of Pregabalin and Gabapentin

(Source: Clinical Pharmacokinetics)

Gabapentin Extended-Release Tablets for the Treatment of Patients with Postherpetic Neuralgia: A Randomized, Double-Blind, Placebo-Controlled, Multicentre Study

(Source: Clinical Drug Investigation)<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>

Characterisation of sensory abnormalities observed in an animal model of multiple sclerosis: A behavioural and pharmacological study

Abstract: Multiple sclerosis is a chronic inflammatory demyelinating disease, associated, in 50‚??80% of patients, with persistent pain. While the type of pain that affects these patients is being more documented, the mechanisms underlying this pathology are still poorly understood and animal models of such chronic pain associated with MS are required. The aim of our study was to characterize the sensory abnormalities and in particular the clinical signs linked to persistent pain in two models of Experimental Autoimmune Encephalomyelitis (EAE) in the rat. This behavioural characterization tested several sensory modalities such as mechanical and thermal (heat/cold) hyperalgesia or allodynia and explored some of these modalities on two different extremities: the hindpaws and the tail. Our st...

Gabapentin abuse: Addiction: 2 case reports

(Source: Reactions)

Treatment Options for Parasomnias

Parasomnias are undesirable physical or experiential events that occur in and around sleep. Treatments include reassurance in some cases, various forms of cognitive-behavioral therapy (CBT), and pharmacologic agents. Cognitive restructuring, imagery rehearsal, relaxation, hypnosis, desensitization, and anticipatory awakenings are some of the common CBT and nonpharmacologic interventions. Medications that are used belong to a wide variety of pharmacologic classes, such as őĪ-blockers (prazosin), tricyclic antidepressants (imipramine and clomipramine), selective serotonin reuptake inhibitors, benzodiazepines (diazepam and clonazepam), anticonvulsants (topiramate and gabapentin), desmopressin acetate, and anticholinergic agents (oxybutynin and tolterodine). Data on efficacy are only available...

THERAPENTIN-90 (Gabapentin) Capsule [Physician Therapeutics LLC]

Updated Date: Sep 3, 2010 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

Gabapentin Enacarbil Eases Symptoms in RLS

SAN ANTONIO ‚?? Long-term use of gabapentin enacarbil for treatment of restless leg syndrome does not lead to the symptom augmentation that commonly occurs with dopaminergic agents, a study shows. (Source: Clinical Neurology News)<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>

Thermal antinociceptive effect of orally administered gabapentin in healthy cats.

Conclusions and Clinical Relevance-At the doses evaluated, orally administered gabapentin did not affect the thermal threshold in healthy cats and therefore did not appear to provide thermal antinociception. (Am J Vet Res 2010;71:1027-1032). PMID: 20807141 [PubMed - in process] (Source: American Journal of Veterinary Research)

Evidence-based approaches to pain in advanced cancer.

Authors: Dy SM Pain is a source of suffering in most advanced cancer patients, but many effective treatments exist. We updated previous systematic reviews on cancer pain treatment with targeted literature searches. Addressing pain involves comprehensive assessment, including other symptoms and sources of distress and barriers to pain management, and investigating potential etiologies and oncological emergencies when potential benefits exceed burdens. Initial treatment may involve acetaminophen or nonsteroidal anti-inflammatory agents, although opioids should be considered quickly if not effective or for severe pain. The initial approach also includes education and psychosocial interventions as appropriate. Neuropathic pain and bony pain may require specific interventions if initial tre...

Lyrica for Bipolar Disorder?

A reader asks, "Anyone have any success using Lyrica (a drug for treatment of fibromyalgia) in place of other mood stabilizers/anticonvulsants?" Lyrica - generic name pregabalin - is approved by the FDA to treat fibromyalgia, nerve pain associated with diabetes and shingles, and as an add-on treatment for epilepsy (in Europe it is also approved for Generalized Anxiety Disorder). Literature describes Lyrica as a "successor" to Neurontin - generic name gabapentin - another anticonvulsant. Studies show that Lyrica is more potent than Neurontin, allowing lower dosages to be used and thus a lower risk of side effects. Read Full PostLyrica for Bipolar Disorder? originally appeared on About.com Bipolar Disorder on Saturday, September 4th, 2010 at 16:07:23.Permalink | Comment | Email this (Sourc...

Hiding in Plain Sight: A Case of Tarlov Perineural Cysts

A 52-year-old woman sought help for intractable lumbosacral pain, which began after she lifted a heavy object and fell onto her back more than 2 decades ago. Additional symptoms included burning, numbness, tingling, and pain in her right hip, posterior thigh, leg, and toes, and diminished sensation and sensitivity throughout her right leg and foot. Muscle spasms/cramps, which often interrupted sleep, were intermittently present in her right buttock and right lower extremity. Right-foot drop impaired her ability to walk, and she used a wheeled walker with a seat because she could not walk more than a few steps without sitting. Other problems included: Severe pressure-type headaches, chronic abdominal and pelvic pain, cervical and thoracic back pain, frequent urinary tract infections, and ur...

Managing menopausal symptoms and depression in tamoxifen users: Implications of drug and medicinal interactions

Conclusions: Clinicians should remain cautious about using strong inhibitors and/or inducers of cytochrome 2D6 and 3A4 concomitantly with tamoxifen. Use of natural menopausal supplements and diets rich in isoflavones should not be encouraged in tamoxifen users until more data is available. There are however safe treatments for hot flashes and depression in tamoxifen users. (Source: Maturitas)<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>

Characterization of the acute and persistent pain state present in K/BxN serum transfer arthritis

Abstract: Rheumatoid arthritis (RA) is a chronic autoimmune arthritis that affects approximately 1% of the population. Synovial inflammation cannot fully explain the level of pain reported by patients and facilitation of pain processing at the spinal level has been implicated. We characterized the K/BxN serum transfer arthritis model as a model of joint inflammation-induced pain and examined pharmacologic responsiveness and spinal glia activation. Mechanical allodynia developed congruently with joint swelling. Surprisingly, allodynia persisted after resolution of inflammation. At the peak of joint inflammation (days 4‚??10), hypersensitivity was attenuated with i.p. etanercept, gabapentin, and ketorolac. Following resolution of synovial inflammation (days 19‚??23), only gabapentin relieved...

Gabapentin: Paraplegia and slurred speech in an elderly patient: case report

(Source: Reactions)

Original Article: Treatment: Comparison of the efficacy and safety of tramadol/acetaminophen combination therapy and gabapentin in the treatment of painful diabetic neuropathy

Diabet. Med. 27, 1033‚??1040 (2010) (Source: Diabetic Medicine)

Gabapentin: Delusions of parasitosis in an elderly patient: case report

(Source: Reactions)

Gabapentin: Exacerbation of myasthenia gravis in an elderly patient: case report

(Source: Reactions)<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>

Best Practice Guide for the Treatment of Nightmare Disorder in Adults

Summary of Recommendations: Prazosin is recommended for treatment of Posttraumatic Stress Disorder (PTSD)-associated nightmares. Level A Image Rehearsal Therapy (IRT) is recommended for treatment of nightmare disorder. Level A Systematic Desensitization and Progressive Deep Muscle Relaxation training are suggested for treatment of idiopathic nightmares. Level B Venlafaxine is not suggested for treatment of PTSD-associated nightmares. Level B Clonidine may be considered for treatment of PTSD-associated nightmares. Level C The following medications may be considered for treatment of PTSD-associated nightmares, but the data are low grade and sparse: trazodone, atypical antipsychotic medications, topiramate, low dose cortisol, fluvoxamine, triazolam and nitrazepam, phenelzine, gabapentin,...

The evidence for pharmacological treatment of neuropathic pain

Abstract: Randomized, double-blind, placebo-controlled trials on neuropathic pain treatment are accumulating, so an updated review of the available evidence is needed. Studies were identified using MEDLINE and EMBASE searches. Numbers needed to treat (NNT) and numbers needed to harm (NNH) values were used to compare the efficacy and safety of different treatments for a number of neuropathic pain conditions. One hundred and seventy-four studies were included, representing a 66% increase in published randomized, placebo-controlled trials in the last 5years. Painful poly-neuropathy (most often due to diabetes) was examined in 69 studies, postherpetic neuralgia in 23, while peripheral nerve injury, central pain, HIV neuropathy, and trigeminal neuralgia were less often studied. Tricyclic antide...

Depomed Reaches SPA Agreement With FDA for Phase 3 Hot Flash Trial

MENLO PARK, Calif., Aug. 11, 2010 (GLOBE NEWSWIRE) -- Depomed, Inc. (Nasdaq:DEPO) announced today that it has reached agreement with the U.S. Food and Drug Administration (FDA) regarding a Special Protocol Assessment (SPA) on the design and analysis of Breeze 3, a Phase 3 trial evaluating Serada(r) (extended release gabapentin tablets) for menopausal hot flashes. (Source: Medical News (via PRIMEZONE))

NEURONTIN (Gabapentin) Capsule NEURONTIN (Gabapentin) Tablet, Film Coated NEURONTIN (Gabapentin) Solution [Parke-Davis Div Of Pfizer Inc]

Updated Date: Aug 10, 2010 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

Intensive care management of patients with acute intermittent porphyria: Clinical report of four cases and review of literature

Madhur Mehta, Girija P Rath, Uma P Padhy, Manish Marda, Charu Mahajan, Hari H DashIndian Journal of Critical Care Medicine 2010 14(2):88-91Acute intermittent porphyria (AIP), the most common and the most severe form of acute hepatic porphyria, is an autosomal dominant condition. It results from lower-than-normal levels (less than 50&#x0025;) of porphobilinogen (PBG) deaminase. Patients may present commonly with gastrointestinal complaints and neuropsychiatric manifestations. Diagnosis may be confirmed with the presence of intermediary metabolites of haem synthesis, amino levulinic acid (ALA) and PBG in urine or with specific enzyme assays. Abdominal pain is the most common symptom (90&#x0025;). Peripheral polyneuropathy, primarily motor with flaccid paresis of proximal musculature, with or...<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>

Dried plasma spots as an alternative sample collection technique for the quantitative LC-MS/MS determination of gabapentin.

Authors: Kolocouri F, Dotsikas Y, Loukas YL Dried plasma spots were employed as an alternative sample collection technique for the quantitative determination of gabapentin in human plasma, using an automated liquid chromatography tandem mass spectrometry method. After the methanolic extraction of single plasma, 1/8-in. disks which contained only 1.98 muL plasma volume, were placed in 96-well format plates, then gabapentin and its internal standard, 4-aminocyclohexanecarboxylic acid, were derivatized with n-butanol/HCl (3 M) and detected as butyl esters. The assay exhibited excellent linearity over the concentration range of 40.0-10.0 x 10(3) ng/mL, which is suitable for the determination of gabapentin after per os administration of a single tablet. Variations in intra- and inter-assay ...

Intensive care management of patients with acute intermittent porphyria: Clinical report of four cases and review of literature

Madhur Mehta, Girija P Rath, Uma P Padhy, Manish Marda, Charu Mahajan, Hari H DashIndian Journal of Critical Care Medicine 2010 14(2):88-91Acute intermittent porphyria (AIP), the most common and the most severe form of acute hepatic porphyria, is an autosomal dominant condition. It results from lower-than-normal levels (less than 50&#x0025;) of porphobilinogen (PBG) deaminase. Patients may present commonly with gastrointestinal complaints and neuropsychiatric manifestations. Diagnosis may be confirmed with the presence of intermediary metabolites of haem synthesis, amino levulinic acid (ALA) and PBG in urine or with specific enzyme assays. Abdominal pain is the most common symptom (90&#x0025;). Peripheral polyneuropathy, primarily motor with flaccid paresis of proximal musculature, with or...

Comparative pharmacodynamic and pharmacokinetic analysis of two anticonvulsant halo derivatives of 2,2,3,3-tetramethylcyclopropanecarboxamide, an amide of a cyclic analog of valproic acid

Conclusions: Based on their potent anticonvulsant activity and lack of teratogenicity, [alpha]-F-TMCD and [alpha]-Cl-TMCD have the potential for development as new antiepileptics and central nervous system (CNS) drugs. (Source: Epilepsia)

Depomed Says Pfizer Has Not Disputed Application

From Associated Press (August 4, 2010) MENLO PARK, Calif. -- Depomed Inc. said Tuesday Pfizer Inc. has not yet filed a lawsuit over attempts to make an extended-release version of Pfizer Inc.'s Neurontin. Neurontin was approved by U.S. regulators a... (Source: Drugs.com - Pharma News)

Above-level mechanical hyperalgesia in rats develops after incomplete spinal cord injury but not after cord transection, and is reversed by amitriptyline, morphine and gabapentin

Abstract: Spinal cord injury (SCI) is a major cause of persistent neuropathic pain of central origin. Recent evidence suggests neuropathic pain in clinically complete SCI patients correlates with limited sensory function below the lesion (sensory discomplete). On this basis we examined if the onset of mechanical hyperalgesia was different in rodents after a severe incomplete clip-compression SCI versus a complete spinal cord transection at thoracic segment T13. Above-level withdrawal behaviors evoked by forepaw stimulation provided evidence of mechanical hyperalgesia after incomplete but not complete SCI, whereas below-level responses evoked by hindpaw stimulation revealed hypersensitivity after both injuries. The latency of the above-level response was 4‚??5 wks but was longer after a mod...<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>

Effectiveness of antiepileptic or antidepressant drugs when added to opioids for cancer pain: systematic review.

Authors: Bennett MI Neuropathic pain mechanisms are present in up to 40% of patients with cancer pain. In these situations, additional or adjuvant analgesic drugs (such as antidepressants or antiepileptics) are often required to optimize pain control alongside standard opioid therapy. This systematic review aimed to determine the effectiveness of antidepressants and antiepileptics when added to opioids, compared to opioids alone, for the management of pain caused directly by cancer. Prospective clinical studies, published in English that used a before-after design or randomized or non-randomized group comparisons were identified. Data were extracted on pain intensity, pain relief and adverse events. Eight studies were eligible (five randomized controlled trials) that recruited 465 pati...

Some newer antiepileptic drugs might increase risk of suicidal behaviour

Source: Neurology Area: News An observational study found that use of some newer antiepileptic drugs was associated with an increased risk of suicidal behaviour and self-harm. &nbsp; The authors of this paper note that a recent meta-analysis of controlled trials found an increased incidence of suicidal thoughts and behaviour associated with some anti-epileptic drugs: they carried out an observational study to investigate whether this could be detected in a practice setting. They used data from the UK GPRD to identify a cohort of patients with epilepsy treated with antiepileptic drugs: cases were those with diagnoses of suicidal behaviour or self-harm, and controls were age and sex matched. Drugs were classified into four groups barbiturates, conventional antiepileptic drugs, and newer...

Use of antiepileptic drugs in epilepsy and the risk of self-harm or suicidal behavior

Conclusions: Newer AEDs with a rather high frequency of depressive symptoms in clinical trials may also increase the risk of self-harm or suicidal behavior in clinical practice. For the most commonly used other groups of AEDs, no increase in risk was observed. (Source: Neurology)

THERAPENTIN-90 (Gabapentin) Capsule [Physician Therapeutics LLC]

Updated Date: Jul 22, 2010 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

FANATREX (Gabapentin) Kit [Fusion Pharmaceuticals LLC]

Updated Date: Jul 20, 2010 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>

A Tropomyosine Receptor Kinase Inhibitor Blocks Spinal Neuroplasticity Essential for the Anti-Hypersensitivity Effects of Gabapentin and Clonidine in Rats With Peripheral Nerve Injury

This study demonstrates that spinal trk signaling after nerve injury is important to neuroplasticity of these systems, which is critical for the analgesic action of common treatments for neuropathic pain. (Source: The Journal of Pain)

Review: Neuropathic pain - diagnosis, pathophysiological mechanisms, and treatment

Source: Lancet Neurology Area: News The Lancet Neurology has featured a review on the diagnosis and management of neuropathic pain. Examples of neuropathic pain include painful polyneuropathy, postherpetic neuralgia, trigeminal neuralgia, and post-stroke pain. &nbsp; Pharmacological treatments discussed included: .&nbsp;Antidepressants with both norepinephrine and serotonin re-uptake inhibition .&nbsp;Calcium channel alfa-2-delta ligands gabapentin and pregabalin .&nbsp;Opioids .&nbsp;Topical lidocaine .&nbsp;Other antiepileptics .&nbsp;Combination therapy (Source: NeLM - News)

Lack of analgesic efficacy of spinal ondansetron on thermal and mechanical hypersensitivity following spinal nerve ligation in the rat.

Authors: Peters CM, Hayashida KI, Ewan EE, Nakajima K, Obata H, Xu Q, Yaksh TL, Eisenach JC The balance between descending inhibition and facilitation is thought to be disturbed in chronic pain states. Increased facilitation by spinally released serotonin has been suggested by demonstration that mechanically evoked neuronal responses of wide dynamic range neurons are inhibited by 5-HT3 receptor antagonists in rats following spinal nerve ligation (SNL) but not sham operation. Despite these physiologic data, the effects of spinal 5-HT3 receptor blockade on behavioral hypersensitivity and neurochemical alterations in spinal serotonergic system have not been thoroughly investigated following spinal nerve ligation in the rat. To test this, we acutely injected intrathecal ondansetron in rats...

Effective and cost-effective clinical trial recruitment strategies for postmenopausal women in a community-based, primary care setting

Conclusion: Newspaper advertisements were the most successful method to recruit postmenopausal women into a community-based, primary care RCT. (Source: Contemporary Clinical Trials)

GlaxoSmithKline And XenoPort Report Top-Line Phase 2b Results For GSK1838262/XP13512 As A Prophylactic Treatment For Migraine Headache

GlaxoSmithKline (NYSE:GSK) and XenoPort, Inc. (Nasdaq:XNPT) announced today that GSK1838262/XP13512 (gabapentin enacarbil) did not demonstrate a statistically significant improvement compared to placebo as a prophylactic treatment for migraine headaches. This phase 2b dose-ranging study evaluated the efficacy, safety and tolerability of GSK1838262 in adults diagnosed with migraine headache (with or without aura) according to the International Headache Society criteria... (Source: Health News from Medical News Today)<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>

Opioid Utilization and Health-Care Costs among Patients with Diabetic Peripheral Neuropathic Pain Treated with Duloxetine vs. Other Therapies

Conclusions: DPNP patients who initiated duloxetine therapy were less likely to have subsequent opioid use and had lower health-care costs than SOC patients. (Source: Pain Practice)

Genotoxic evaluation of antiepileptic drugs by drosophila somatic mutation and recombination test.

This study shows that phenytoin and gabapentin have genotoxic effects according to the SMAR test; however pregabalin displays lower genotoxicity in the SMAR assay when compared with the other two anti-epileptics. The results also show that all AED concentrations lower the survival rate of the flies. PMID: 20600525 [PubMed - as supplied by publisher] (Source: Food and Chemical Toxicology)

Pharmacokinetics of gabapentin in cats.

Conclusions and Clinical Relevance-The disposition of gabapentin in cats was characterized by a small volume of distribution and a low clearance. PMID: 20594085 [PubMed - in process] (Source: American Journal of Veterinary Research)

Gabapentin Enacarbil Promising for Restless Legs Syndrome

SAN ANTONIO ‚?? Long-term use of gabapentin enacarbil for treatment of restless leg syndrome does not lead to the symptom augmentation that commonly occurs with dopaminergic agents, a study shows. (Source: Family Practice News)<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>

Pregabalin and gabapentin in matched patients with peripheral neuropathic pain in routine medical practice in a primary care setting: Findings from a cost-consequences analysis in a nested case-control study.

Conclusion: Pregabalin appeared to be associated with greater reduction in mean weekly intensity of pain, but there were no significant differences in cost. PMID: 20678683 [PubMed - as supplied by publisher] (Source: Clinical Therapeutics)

Gabapentin suppresses cortical spreading depression susceptibility

Authors: Ulrike Hoffmann, Ergin Dilek&#246;z, Chiho Kudo & Cenk Ayata (Source: Journal of Cerebral Blood Flow)

Epilepsy (partial)

Conclusion unchanged. Categorisation unchanged (Unknown effectiveness). Educational programmes for people with partial or generalised epilepsy One systematic review, search date updated, no new evidence found. Categorisation unchanged (Likely to be beneficial). Relaxation plus behavioural modification therapy for people with partial or generalised epilepsy One systematic review, search date updated, no new evidence found. Categorisation unchanged (Unknown effectiveness). (Source: Clinical Evidence)

Drugs for restless legs syndrome

Mirapex and Requip are approved, and others are in development. Two drugs are now approved to combat restless legs syndrome &#8212; the dopamine boosters Mirapex and Requip. In addition, some drugs approved for other conditions can be legally prescribed for RLS. These include Neurontin, a pain and anti-seizure medication, pain relievers such as oxycodone, codeine and methadone, and anti-anxiety drugs such as the benzodiazepines. (Source: L.A. Times - Health)

Economic burden associated with the use of generic antiepileptic drugs in the United States.

This study quantifies the economic burden associated with generic-versus-branded use of antiepileptic drugs (AEDs) in the United States. Adult patients with epilepsy receiving carbamazepine, gabapentin, phenytoin, primidone, or zonisamide were selected from the PharMetrics database. By use of an open-cohort design, patients were classified into mutually exclusive periods of generic-versus-branded AED use. Annualized cost differences (CDs) between periods were estimated using multivariate regressions. Results were stratified into stable versus unstable epilepsy and newer-generation versus older-generation AEDs. A total of 33,625 patients (52% male, mean age=51years) were observed. Periods of generic AED treatment were associated with higher medical service costs (adjusted CD [95% CI]=$3186 ...<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>

Epilepsy (generalised)

New option(s) added for: Levetiracetam New option added for which we found no RCTs satisfying Clinical Evidence inclusion criteria. Categorised as Likely to be beneficial, based on consensus. Gabapentin New option added for which we no RCTs satisfying Clinical Evidence inclusion criteria. Categorised as Likely to be beneficial, based on consensus. Addition of second-line antiepileptics (in drug-resistant generalised epilepsy) New option added for which we found three RCTs. One RCT found that adding lamotrigine to usual drug treatment reduced seizures in people with generalised tonic clonic or absence seizures, compared with adding placebo to usual drug treatment. Two RCTs found that adding levetiracetam to us...

Withdrawal Symptoms After Gabapentin Discontinuation

A withdrawal syndrome associated with gabapentin may resemble benzodiazepine and ethanol withdrawal. American Journal of Health-System Pharmacy (Source: Medscape Today Headlines)

Nortriptyline and gabapentin, alone and in combination for neuropathic pain: a double-blind, randomised controlled crossover trial. Gilron I, Bailey JM, Tu D, Holden RR, Jackson AC, Houlden RL. Lancet 2009;374(9697):1252‚??61. Epub 2009 Sep 30

BACKGROUND: Drugs for neuropathic pain have incomplete efficacy and dose-limiting side-effects when given as monotherapy. We assessed the efficacy and tolerability of combined nortriptyline and gabapentin compared with each drug given alone. (Source: The Spine Journal)

Gabapentin opens window of communication

For patients with quadriplegia, mutism and lower cranial nerve paralysis (locked-in syndrome), their only means of interacting with others is through vertical gaze and upper eyelid movements, using eye-coded communication strategies. (Source: ScienceDaily Headlines)

Quadriplegia, Mutism And Lower Cranial Nerve Paralysis: Gabapentin Opens Window Of Communication

For patients with quadriplegia, mutism and lower cranial nerve paralysis (locked-in syndrome), their only means of interacting with others is through vertical gaze and upper eyelid movements, using eye-coded communication strategies. In the June issue of Mayo Clinic Proceedings, researchers from Italy describe four patients with locked-in syndrome who also had dancing eye syndrome (opsoclonus-myoclonus syndrome)... (Source: Health News from Medical News Today)<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>

Gabapentin Enacarbil Improves Sleep Disturbance in Restless Legs Syndrome

The modified drug improves absorption and does not appear to cause augmentation. Medscape Medical News (Source: Medscape Neurology and Neurosurgery Headlines)

Fatty Acid Amide Hydrolase and Monoacylglycerol Lipase Inhibitors Produce Anti-Allodynic Effects in Mice Through Distinct Cannabinoid Receptor Mechanisms

In conclusion, although endogenous cannabinoids do not appear to play a tonic role in long-term expression of neuropathic pain states, both FAAH and MAGL represent potential therapeutic targets for the development of pharmacological agents to treat chronic pain resulting from nerve injury.Perspective: This article presents data addressing the cannabinoid receptor mechanisms underlying the anti-allodynic actions of endocannabinoid catabolic enzyme inhibitors in the mouse sciatic nerve ligation model. Fatty acid amide hydrolase and monoacylglycerol lipase inhibitors reduced allodynia through distinct cannabinoid receptor mechanisms. These enzymes offer potential targets to treat neuropathic pain. (Source: The Journal of Pain)

Mayo Clinic Proceedings: Gabapentin Opens Window of Communication

In the June issue of Mayo Clinic Proceedings, researchers from Italy describe four patients with locked-in syndrome who also had dancing eye syndrome (opsoclonus-myoclonus syndrome). (Source: News from Mayo Clinic)

Mayo Clinic Proceedings: Gabapentin opens window of communication

(Mayo Clinic) For patients with quadriplegia, mutism and lower cranial nerve paralysis (locked-in syndrome), their only means of interacting with others is through vertical gaze and upper eyelid movements, using eye-coded communication strategies. (Source: EurekAlert! - Medicine and Health)<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>

The Effects of Intravenous Gabapentin Administration on the Minimum Alveolar Concentration of Isoflurane in Cats.

Conclusions: We conclude that gabapentin did not have a detectable effect on the MAC of isoflurane in cats. PMID: 20547821 [PubMed - as supplied by publisher] (Source: Anesthesia and Analgesia)

APSS: Gabapentin Enacarbil May Relieve RLS Pain (CME/CE)

SAN ANTONIO (MedPage Today) -- The pain associated with restless legs syndrome (RLS) -- reported by some 60% of RLS patients -- improved significantly after three months of treatment with the investigational compound gabapentin enacarbil, researchers reported here. (Source: MedPage Today Meeting Coverage)

Gabapentin Effective in Treating Alcohol Dependence

Gabapentin reduces relapse rates in newly abstinent alcoholics, according to research presented at the 27th World Congress of the International College of Neuropsychopharmacology. Reuters Health Information (Source: Medscape Medical News Headlines)

Gabapentin and pregabalin in the treatment of fibromyalgia: a systematic review and a meta-analysis

Conclusions: The analysis indicates that PB at a dose of 450 mg per day is most likely effective in treating FBM, although AE are not negligible. Further evidence is necessary for more conclusive inferences. (Source: Journal of Clinical Pharmacy and Therapeutics)

Pharmacokinetic profile and behavioral effects of gabapentin in the horse

Terry, R. L., McDonnell, S. M., van Eps, A. W., Soma, L. R., Liu, Y., Uboh, C. E., Moate, P. J., Driessen, B. Pharmacokinetic profile and behavioral effects of gabapentin in the horse. J. vet. Pharmacol. Therap. doi: 10.1111/j.1365-2885.2010.01161.x. Gabapentin is being used in horses although its pharmacokinetic (PK) profile, pharmacodynamic (PD) effects and safety in the equine are not fully investigated. Therefore, we characterized PKs and cardiovascular and behavioral effects of gabapentin in horses. Gabapentin (20 mg/kg) was administered i.v. or p.o. to six horses using a randomized crossover design. Plasma gabapentin concentrations were measured in samples collected 0[ndash]48 h postadministration employing liquid chromatography-tandem mass spectrometry. Blood pressures, ECG, and sed...<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>

Gabapentin for the treatment of pain syndrome related to radiation-induced mucositis in patients with head and neck cancer treated with concurrent chemoradiotherapy

This retrospective study evaluated the efficacy of gabapentin for the treatment of pain syndromes related to radiation-induced mucositis in patients with head and neck cancers treated with concurrent chemoradiation.Data from 42 patients with head and neck malignancies treated with concurrent chemoradiotherapy using an intensity-modulated radiotherapy technique were analyzed. Gabapentin was initiated in the second week of radiotherapy. Opiates were prescribed in addition to gabapentin as clinically indicated to obtain adequate pain control.At a median dose of 2700 mg/day of gabapentin, only 33% and 55% of patients required additional low-dose narcotic medications for pain control during the third and fourth week of treatment, respectively, despite exhibiting a grade 2 or higher mucositis in...

DTB editorial questions NICE neuropathic pain guideline recommending pregabalin

Source: Drug and Therapeutics Bulletin Area: News This editorial in the Drug and Therapeutics Bulletin (DTB) questions the recommendation in the recent guideline on neuropathic pain from NICE that clinicians should "offer oral amitriptyline or pregabalin as first-line treatment." The guideline excluded gabapentin, based on indirect comparisons, suggesting that it offers less net benefit, is less cost-effective, and requires more complex dosing and titration compared with pregabalin. However, the DTB notes that pregabalin is still a black triangle drug and this too should be considered in any comparison with the much longer established gabapentin. &nbsp; The DTB concludes "the guideline's promotion of pregabalin creates a dilemma for those who know from the published data that gabapent...

Mylan Receives Approval for Generic Version of Neurontin(R) Tablets

PITTSBURGH, June 4 (HSMN NewsFeed) -- Mylan Inc. (Nasdaq:MYL ) today announced that its subsidiary Matrix Laboratories Limited has received final approval from the U.S. Food and Drug Administration (FDA) for its Abbreviated New Drug Application (ANDA) fo... Biopharmaceuticals, Generics, FDAMylan, gabapentin, Neurontin, Pfizer (Source: HSMN NewsFeed)

Gabapentin Therapy for Ocular Opsoclonus-Myoclonus Restores Eye Movement Communication in a Patient With a Locked-In Syndrome

The experience with a patient with locked-in syndrome suffering from opsoclonus&mdash;myoclonus symptoms is described: gabapentin successfully reversed the symptoms, just favoring the regaining of eye-dependent communication strategies. (Source: Neurorehabilitation and Neural Repair)

Gabapentin 300mg capsules granted "NCSO" status

Source: PSNC (Pharmaceutical Services Negotiating Committee) Area: News According to a report by the Pharmaceutical Services Negotiating Committee (PSNC), gabapentin 300mg capsules have been granted "NCSO" status for the month of May 2010, which means that prescriptions for gabapentin 300mg capsules must be endorsed with the initials "NCSO" and full details of the product dispensed (e.g. manufacturer, brand name or price if it is an uncommon item and pack size). &nbsp; If any of this information is missing, payment will be based on the Drug Tariff price rather than the endorsed product. The NCSO concession only lasts for the month it is granted. &nbsp; NCSO status is applied when there is a stock shortage of a product in Part VIII of the Drug Tariff or the product has been discont...<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>

Gabapentin for spasticity and autonomic dysreflexia after severe spinal cord injury

Authors: A G Rabchevsky, S P Patel, H Duale, T S Lyttle, C R O'Dell & P H Kitzman (Source: Spinal Cord)

Comparison of the efficacy and safety of tramadol/acetaminophen combination therapy and gabapentin in the treatment of painful diabetic neuropathy

(Source: Diabetic Medicine)

New Uses for Older Drugs: The Tales of Aspirin, Thalidomide, and Gabapentin

(Source: Mayo Clinic Proceedings)

Long-term Maintenance Treatment of Restless Legs Syndrome With Gabapentin Enacarbil: A Randomized Controlled Study

CONCLUSION: Gabapentin enacarbil, 1200 mg, maintained improvements in RLS symptoms compared with placebo and showed long-term tolerability in adults with moderate to severe primary RLS for up to 9 months of treatment. (Source: Mayo Clinic Proceedings)

Opsoclonus-Myoclonus Syndrome in Patients With Locked-in Syndrome: A Therapeutic Porthole With Gabapentin

In this study, 4 patients presenting with locked-in syndrome complicated by opsoclonus-myoclonus syndrome were continuously treated with gabapentin up to 1200 mg/d. The treatment resulted in a rapid and long-lasting resolution of opsoclonus-myoclonus symptoms without adverse effects. After 2 weeks, patients showed voluntary attempts to communicate through eye blinking and thereafter regained voluntary control of full eye movements. This event enabled them to regain a communication channel with relatives and physicians and to start using eye-controlled brain-computer interfaces. Because of its effectiveness in restoring eye movement control, gabapentin opened a communicative porthole in the patients' lives. Since opsoclonus may be related to disorders of the inhibitory control of saccadic b...<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>

Gabapentin toxicity associated with low GFR

(Source: Reactions)

Withdrawal symptoms after gabapentin discontinuation.

Conclusion A patient developed apparent withdrawal symptoms beginning two days after gabapentin therapy was discontinued. The symptoms were unresponsive to treatment with benzodiazepines but completely resolved with the reinitiation of gabapentin therapy. PMID: 20484214 [PubMed - in process] (Source: American Journal of Health-System Pharmacy : AJHP)

Gabapentin improves cold-pressor pain responses in methadone-maintained patients

Abstract: Individuals on methadone maintenance for the treatment of addiction (MM) are demonstrated to be hyperalgesic to cold-pressor pain in comparison to matched controls and ex-opioid addicts, a finding described as clinical evidence of opioid-induced hyperalgesia (OIH). Interestingly, opioids induce hyperalgesia via many of the same neuro-inflammatory and central sensitization processes that occur with the development of neuropathic pain. Evaluated in this study was the efficacy of a key pharmacotherapy for neuropathic pain, gabapentin (GPN), to reverse OIH in MM patients. Utilizing a clinical trial design and double blind conditions, changes in cold-pressor pain threshold and tolerance following a 5-week trial of GPN (titrated to 2400mg/day) were evaluated at peak and trough methadon...

Medications Acting on the Gaba System in the Treatment of Alcoholic Patients.

Authors: Caputo F, Bernardi M Gamma aminobutyric acid (GABA) represents the major inhibitory neurotransmitter of the central nervous system. Ethanol as well as benzodiazepines (BDZs) and some anticonvulsant drugs directly affect GABAA receptors inducing similar anxiolytic, sedativehypnotic, and anticonvulsant effects. Since BDZs have proven their efficacy in ameliorating symptoms and in decreasing the risk of seizures and delirium tremens, they are the drugs of choice for the treatment of alcohol withdrawal syndrome (AWS). However, due to their addictive potential and lack of safety when combined with alcohol, BDZs are usually not recommended for the maintenance of alcohol abstinence. Other GABA-ergic medications represent potentially promising drugs useful in the treatment of AWS and ...

Acute pain after total hip arthroplasty does not predict the development of chronic postsurgical pain 6 months later

Conclusion&nbsp;&nbsp;Neither maximum movement-evoked acute pain, nor any other factor measured, predicted the presence of CPSP at 6&nbsp;months. Further research is needed to identify risk factors for CPSP after total hip arthroplasty. Content Type Journal ArticleCategory Original ArticleDOI 10.1007/s00540-010-0960-zAuthors Hance Clarke, Toronto General Hospital, Acute Pain Research Unit Department of Anesthesia and Pain Management 200 Elizabeth Street, Eaton North 3EB 317 Toronto ON M5G 2C4 CanadaJoseph Kay, Holland Orthopedic and Arthritic Centre, Sunnybrook Health Sciences Centre Toronto ON CanadaNicholas Mitsakakis, Toronto General Hospital, Acute Pain Research Unit Department of Anesthesia and Pain Management 200 Elizabeth Street, Eaton North 3EB 317 Toronto ON M5G 2C4 Ca...<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>

Gabapentin for the Treatment of Cancer-Related Pain Syndromes.

Conclusions: Given the significant benefits of gabapentin and the combination of gabapentin with opioids for the treatment of neuropathic pain, randomized clinical trials are needed to establish the role of these analgesic regimens for the treatment of neuropathic cancer pain. PMID: 20482492 [PubMed - as supplied by publisher] (Source: Reviews on Recent Clinical Trials)

Pharmacokinetics of Gabapentin in a Novel Gastric-Retentive Extended-Release Formulation: Comparison With an Immediate-Release Formulation and the Effect of Dose Escalation and Food.

The objectives of the 3 phase I studies described herein were (1) to compare the pharmacokinetics of gabapentin delivered from a novel gastric-retentive dosage form vs an immediate-release formulation, (2) to assess the dose proportionality of the gastric-retentive extended-release formulation, and (3) to determine the effect of food on the pharmacokinetics of gabapentin delivered from this formulation. The time to reach maximum plasma concentration (tmax) was extended for gabapentin delivered from the gastric-retentive extended-release formulation compared with the immediate-release formulation. A dose-related increase in both the maximum plasma concentration (Cmax) and the area under the plasma concentration-time curve (AUC) was observed as the gabapentin dose increased from 600 to 2400 ...

Generic antiepileptic drugs and associated medical resource utilization in the United States

Conclusions: Generic antiepileptic drug use was associated with significantly greater medical utilization and risk of epilepsy-related medical events, compared to brand use. This relationship was observed even in patients characterized as stable. AED = antiepileptic drug; CI = confidence interval; ER = emergency room; HR = hazard ratio; ICD = International Classification of Diseases; IRR = incidence rate ratio. (Source: Neurology)

Central Sensitization and CaVőĪ2őī Ligands in Chronic Pain Syndromes: Pathologic Processes and Pharmacologic Effect

Abstract: Central sensitization is one form of long-term plasticity in the central nervous system. Sustained activation of primary sensory fibers supplying dorsal horn can induce long-lasting increases in the discharge amplitude of primary afferent synapses. This is similar to the long-term potentiation that occurs in many other CNS regions. Drugs that limit the short-duration wind-up component of central sensitization include sodium channel blockers, NMDA antagonists, fast-acting opioids and the calcium-channel ligands gabapentin and pregabalin (S-3-(aminomethyl)-5-methylhexanoic acid). Pregabalin, like gabapentin, binds selectively to the CaVőĪ2őī auxiliary subunit of presynaptic voltage-gated calcium channels. The conformational changes induced by this binding inhibit abnormally intense...

Single dose oral gabapentin for established acute postoperative pain in adults

Source: Cochrane Library Area: Evidence > Drug Specific Reviews Abstract: &nbsp; Background Gabapentin is an antiepileptic drug, also used in the treatment of neuropathic pain, which is the subject of a Cochrane review, currently under revision. Its efficacy in treating established acute postoperative pain has not been demonstrated. &nbsp; Objectives To assess the efficacy and safety of single dose oral gabapentin compared with placebo in established acute postoperative pain using methods that permit comparison with other analgesics. &nbsp; Search strategy We searched Cochrane CENTRAL, MEDLINE, EMBASE, and the Oxford Pain Relief Database. Additional studies were sought from reference lists of retrieved articles and reviews. Clinical trials databases were searched for unpublish...<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>

Single dose oral gabapentin for established acute postoperative pain in adults.

CONCLUSIONS: Gabapentin 250 mg is statistically superior to placebo in the treatment of established acute postoperative pain, but the NNT of 11 for at least 50% pain relief over 6 hours with gabapentin 250 mg is of limited clinical value and inferior to commonly used analgesics. Gabapentin 250 mg is not clinically useful as a stand-alone analgesic in established acute postoperative pain, though this is probably the first demonstration of analgesic effect of an antiepileptic in established acute pain. PMID: 20464764 [PubMed - in process] (Source: Cochrane Database of Systematic Reviews)

Progressive steps of polymorphic transformation of gabapentin polymorphs studied by hot-stage FTIR microspectroscopy.

CONCLUSION: A one-step novel hot-stage FTIR microspectroscopy was successfully applied to simultaneously and continuously investigate the progressive processes and steps of thermal-induced polymorphic interconversion of GBP polymorph in the solid state. PMID: 20456832 [PubMed - in process] (Source: J Pharm Pharm Sci)

Pharmacological prophylaxis of chronic migraine: a review of double-blind placebo-controlled trials

Abstract&nbsp;&nbsp;Chronic migraine is an important public health problem. The aim of treatment should be to reduce migraine frequency and its negative impact on functioning, as well as to limit the use of acute medications. These goals may be accomplished by introducing effective prophylaxis. The aim of the present article is to critically review the published evidence on the pharmacological prophylaxis of chronic migraine, analysing published double-blind, placebo-controlled studies on adult patients. The results of the review indicate that tizanidine, gabapentin, valproic acid, and particularly topiramate are effective prophylactics against chronic migraine, with improvements in several endpoints that were significantly superior to those achieved by placebo. However, the differen...

Radio frequency ablation in drug resistant chemotherapy-induced peripheral neuropathy: A case report and review of literature

Yadav Naveen, Philip Frenny Ann, Gogia Vikas, Choudhary Prakash, Rana Shiv Pratap Singh, Mishra Seema, Bhatnagar SushmaIndian Journal of Palliative Care 2010 16(1):48-51Chemotherapy-induced peripheral neuropathy (CIPN) is a frequently encountered complication. It can result from a host of agents. Various modalities of treatment have been advocated, of which a novel method is radio frequency ablation. A 63-year-old male, a case of carcinoma prostrate with bone metastases, presented with tingling and numbness in right upper limb. He was given morphine, gabapentin and later switched to pregabalin, but medications provided only minor relief. Initially he was given stellate ganglion block, then radiofrequency ablation of dorsal root ganglion was done, but it failed to provide complete relief. P...<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>

5% lidocaine medicated plaster in painful diabetic peripheral neuropathy (DPN): a systematic review.

Conclusions: The results suggest that the effects in pain reduction of 5% lidocaine medicated plaster are comparable to those of amitriptyline, capsaicin, gabapentin and pregabalin. Topical agents such as 5%LMP may be associated with fewer and less clinically significant adverse events than is the case for systemic agents. However, the results are limited by the number and size of studies included, and thus further studies are needed. PMID: 20458651 [PubMed - as supplied by publisher] (Source: Swiss Medical Weekly)

Study finds that the combination gabapentin plus nortriptyline reduces neuropathic pain more than either drug alone

(Source: Evidence-Based Medicine)

A Systematic Review of Pharmacologic Treatments of Pain After Spinal Cord Injury

Conclusions: Most studies did not specify participants' types of pain, making it difficult to identify the type of pain being targeted by the treatment. Anticonvulsant and analgesic drugs had the highest levels of evidence and were the drugs most often studied. Gabapentin and pregabalin had strong evidence (5 level 1 RCTs) for effectiveness in treating post-SCI neuropathic pain as did intravenous analgesics (lidocaine, ketamine, and morphine), but the latter only had short-term benefits. Tricyclic antidepressants only showed benefit for neuropathic pain in depressed persons. Intrathecal baclofen reduced musculoskeletal pain associated with spasticity; however, there was conflicting evidence for the reduction in neuropathic pain. Studies assessing the effectiveness of opioids were limited a...

Study Links Four Anticonvulsants to Suicide Risk

The link between anticonvulsant agents and suicidal acts or violent death‚??first revealed in a Food and Drug Administration meta-analysis in 2008‚??appears to have been confirmed for four of the drugs: gabapentin, lamotrigine, oxcarbazepine, and tiagabine, investigators reported. (Source: Internal Medicine News)

Four Anticonvulsants' Link to Suicide Supported

The link between anticonvulsant agents and suicidal acts or violent death‚??first revealed in a Food and Drug Administration meta-analysis in 2008‚??appears to have been confirmed for four of the drugs: gabapentin, lamotrigine, oxcarbazepine, and tiagabine, according to a report in JAMA. (Source: Clinical Psychiatry News)

Gabapentin and pregabalin in the treatment of fibromyalgia: a systematic review and a meta‚?źanalysis

(Source: Journal of Clinical Pharmacy and Therapeutics)

Meningioma causing gabapentin-responsive secondary SUNCT syndrome

In this study, we describe the first case of secondary SUNCT syndrome caused by a meningioma. So far, a clearly effective therapy for SUNCT syndrome has not been known. In this case, however, SUNCT was completely responsive to gabapentin. This underlines that this drug is worthy of being considered as a potential therapeutic option in the treatment of SUNCT syndrome. Content Type Journal ArticleCategory Brief ReportDOI 10.1007/s10194-010-0216-1Authors Anna Kutschenko, University Medical Centre Göttingen Department of Clinical Neurophysiology Robert-Koch-Strasse 40 37099 Göttingen GermanyDavid Liebetanz, University Medical Centre Göttingen Department of Clinical Neurophysiology Robert-Koch-Strasse 40 37099 Göttingen Germany Journal The Journal of Headache and PainOnline...

Effects of Gabapentin or SCP-123 in the Rat Chronic Constriction Injury Neuropathic Pain Model

Conclusions. We concluded that the L/G test is effective in measuring cold hyperalgesia, and both gabapentin and SCP-123 produced an antihyperalgesic effect for cold in the CCI model, which may have clinical implications. (Source: Pain Medicine)

Lumbar spinal stenosis: a brief review of the nonsurgical management.

CONCLUSIONS: Because of their variable quality, published RCTs can provide only limited evidence to formulate recommendations pertaining to the nonsurgical treatment of LSS. In this narrative review, no study was excluded based on factors such as sample size justification, statistical power, blinding, definition of intervention allocation, or clinical outcomes. This aspect may represent a limitation as it may serve to overemphasize evidence derived from "weaker" trials. Further well-designed RCTs are warranted. PMID: 20428988 [PubMed - as supplied by publisher] (Source: Canadian Journal of Anaesthesia)<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>

Reporting of Trials of Gabapentin

To the Editor: In the Special Article on outcome reporting in industry-sponsored trials of gabapentin for off-label use, Vedula et ... (Source: New England Journal of Medicine)

Does Pregabalin (Lyrica&reg;) Help Patients Reduce their Use of Benzodiazepines? A Comparison with Gabapentin using the Norwegian Prescription Database

This study shows that some patients reduced their use of benzodiazepines substantially after starting pregabalin. (Source: Basic and Clinical Pharmacology and Toxicology)

Neurontin side effects: How do I manage them?

Some Neurontin side effects can be troubling and require evaluation by your doctor. (Source: MayoClinic.com Full Feed)

Analgesic effects of gabapentin on mechanical hypersensitivity in a rat model of chronic pancreatitis.

Authors: Liao XZ, Zhou MT, Mao YF, Xu H, Chen H, Sun JH, Xiong YC Gabapentin, an anticonvulsant, is widely accepted as an alternative therapeutic agent for neuropathic pain and has proved to produce analgesic effects in a mouse model of visceral pain. However, it is unknown whether gabapentin is also analgesically effective in chronic pancreatitis. The aim of the present study was to investigate the role and underlying mechanisms of gabapentin in a rat model of chronic pancreatitis. Chronic pancreatitis induced by dibutyltin dichloride (DBTC) produced a marked increase in mechanical sensitivity of the abdomen after the establishment of the model. During the first day to the sixth day in the fourth week, Gabapentin was administered intraperitoneally daily at a dose of 100mg/kg. The beha...<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>

Toxicity of new seizure meds

3.5 out of 5 stars Emergent Complications of the Newer Anticonvulsants. ¬†Wade JF et al. ¬†J Emerg Med 2010;38:231-7. Abstract This instructive article reviews the adverse effects and overdose presentation of some of the newer anticonvulsant medications. ¬†Studying the toxicology of these drugs is often difficult because &#8212; among other impediments &#8212; serum drug levels are not readily available. ¬†In general, overdose on these drugs causes lethargy, sedation, and/or increased seizure activity. ¬†The newer anticonvulsants include: ‚?Ę Topiramate (Topamax¬ģ) &#8211; This drug causes sedation, and a significant decrease in cognition. ¬†Topiramide is a carbonic anhydrase-inhibiting¬†diuretic, and as such can cause metabolic acidosis (non-anion-gap). ¬†Although this effect if often not...

Popular anticonvulsant drugs raise suicide risks

Widely used anticonvulsant drugs, including Pfizer's Neurontin and Novartis' Trileptal, may increase the risk of suicide, attempted suicide and violent death in patients taking them for the first time, U.S. researchers said this week. Compared with... (Source: OrlandoSentinel: Medical Research)

Anticonvulsant Medications and the Risk of Suicide, Attempted Suicide, or Violent Death [Preliminary Communication]

Conclusion&nbsp; This exploratory analysis suggests that the use of gabapentin, lamotrigine, oxcarbazepine, and tiagabine, compared with the use of topiramate, may be associated with an increased risk of suicidal acts or violent deaths. (Source: JAMA)

Some Anticonvulsants Linked to Higher Suicide Risk

Compared with topiramate use, the use of gabapentin, lamotrigine, oxcarbazepine, and tiagabine may be associated with a higher risk of suicidal acts or violent death, according to research published in the April 14 issue of the Journal of the American Medical Association. (Source: Modern Medicine)<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>

Comparative Effectiveness of 10 Antiepileptic Drugs in Older Adults With Epilepsy [Original Contribution]

Conclusion&nbsp; In this study of older adults with epilepsy, lamotrigine was the most effective AED as measured by 12-month retention and seizure freedom, with levetiracetam a close second. Oxcarbazepine was consistently less effective than most other AEDs. (Source: Archives of Neurology)

Safety Pharmacology, Acute Toxicity and Pharmacokinetics of SCP-123 and Acetaminophen

Abstract: We investigated the safety pharmacological effects, that is, motor co-ordination and cardiac arrhythmia of either SCP-123 and/or gabapentin in this study. In addition, we characterized the acute toxicological effect of SCP-123 and acetaminophen (APAP) and evaluated the pharmacokinetic properties of SCP-123 in both in vivo and in vitro test systems. Motor co-ordination was not affected by SCP-123 up to 1000 mg/kg or gabapentin up to 500 mg/kg in na√Įve rats; however, 1000 mg/kg gabapentin produced a reduction in latency after 1 hr. A dose of 100 [mu]M SCP-123 inhibited human ether-√†-go-go-related gene current by 0.5 ¬Ī 0.2% at 10 [mu]M and 0.2 ¬Ī 0.1%. There were no significant changes in plasma glutamic[ndash]oxaloacetic transaminase and glutamate[ndash]pyruvate transaminase lev...

The Placebo Effect Can Kill You

It could be argued that Wikipedia is not the most scholarly or accurate resource for medical information. On the other hand, I am not a physician or a psychologist, so please cut me some slack.&nbsp; From Wikipedia: "The patient is given an inert pill, told that it may improve his/her condition, but not told that it is in fact inert. Such an intervention may cause the patient to believe the treatment will change his/her condition; and this belief may produce a subjective perception of a therapeutic effect, causing the patient to feel their condition has improved. This phenomenon is known as the placebo effect."&lt;!--break--&gt;My first foray into the nebulous world of antidepressants was in 1985 when I was put on Sinequan. It gave me severe cotton mouth, didn't do much for my mood, but ca...

Table of Contents

BALANCE Trial Results: Lithium + Valproate Effective for Bipolar Relapse PreventionEMBOLDEN I and II: Quetiapine Effective for Treating Bipolar DepressionEffects of Duloxetine on WarfarinBenzodiazepine Use in Bipolar Disorder: A STEP-BD ReportThe "Rise and Fall" of Gabapentin for Bipolar DisorderCarbamazepine Extended Release for Pediatric Bipolar DisorderEarly Exposure to Antidepressants, Stimulants and Bipolar DisorderTryptophan for Refractory Bipolar Spectrum DisorderFrom the FDA (Source: The Brown University Psychopharmacology Update)

EFNS guidelines on the pharmacological treatment of neuropathic pain: 2009 revision

Conclusions: There are still too few large-scale comparative studies. For future trials, we recommend to assess comorbidities, quality of life, symptoms and signs with standardized tools and attempt to better define responder profiles to specific drug treatments. (Source: European Journal of Neurology)<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>

Brain perfusion in fibromyalgia patients and its differences between responders and poor responders to gabapentin

Conclusions: The present study revealed brain regions with significant hyperperfusion associated with the default-mode network, in addition to abnormalities in the sensory dimension of pain processing and affective-attentional areas in fibromyalgia patients. Furthermore, hyperperfusion in these areas was strongly predictive of poor response to gabapentin. (Source: Arthritis Research and Therapy)

Gabapentin and Renal Insufficiency

3 out of 5 stars Gabapentin Toxicity in Patients with Chronic Kidney Disease: A Preventable Cause of Morbidity. Zand LZ et al.  AM J Med April 2010;123:367-373. Abstract This retrospective study reviewed patients from 1998 to 2007 in the Mayo Clinic Rochester (MN) database with measured gabapentin levels and known medical outcomes. The study design has a number of flaws, including the fact that the authors do not describe clear methods for their review &#8212; for example, the definition of &#8220;known medical outcome&#8221; is never spelled out.  Nor are there clear goals or hypotheses for the study.  However, this paper is still worth reading because it touches on some valuable clinical pearls. Gabapentin (Neurontin) is an anticonvulsant frequently given as an analgesic and for other...

Pfizer Settles Neurontin Wrongful-Death Suit

Pfizer said it reached a settlement agreement in a wrongful-death lawsuit brought by a woman who claimed her husband's use of the antiseizure drug Neurontin caused him to commit suicide in 2002. (Source: WSJ.com: Health)

Gabapentin Toxicity in Patients with Chronic Kidney Disease: A Preventable Cause of Morbidity

We examined the Mayo Clinic Rochester database from 1998 to 2007 in patients with serum gabapentin measurements and known medical outcomes. A total of 729 patients were stratified according to their estimated glomerular filtration rate: group I, 126 individuals with estimated glomerular filtration greater than 90 mL/min/1.72 mm3; group II, 594 individuals with estimated glomerular filtration less than 90 mL/min/1.72 mm3 without dialysis; group III, 9 individuals with chronic dialysis.Results: Patients in groups II and III had higher serum gabapentin levels (8.39¬Ī0.32 őľL/mL and 58.8¬Ī10.22 őľL/mL, respectively) than in group I (5.52¬Ī0.32 őľL/mL, P (Source: The American Journal of Medicine)

Rehabilitation in practice: Spasticity management.

Authors: Stevenson V This series of articles for rehabilitation in practice aims to cover a knowledge element of the rehabilitation medicine curriculum. Nevertheless they are intended to be of interest to a multidisciplinary audience. The competency addressed in this article is 'The trainee consistently demonstrates a knowledge of the pathophysiology of various specific impairments including spasticity'. Spasticity is an extremely common feature of chronic neurological conditions and, if badly managed, it can result in pain, contractures and pressure sores, all of which can impact on function. It is therefore essential that a multidisciplinary management strategy is in place to help the individual manage their particular situation through education with timely access to interventions i...<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>

158 the possible role of gabapentin with nitric oxide on peripheral nerve regeneration

(Source: European Journal of Pain Supplements)

159 the antinociceptive effects of gabapentin and nitric oxide on neuropathic pain model formed in rats

(Source: European Journal of Pain Supplements)

465 perioperative use of gabapentin/pregabalin for the management of acute postoperative pain: a regional survey

(Source: European Journal of Pain Supplements)

Does Pregabalin (Lyrica¬ģ) Help Patients Reduce their Use of Benzodiazepines? A Comparison with Gabapentin using the Norwegian Prescription Database

(Source: Basic and Clinical Pharmacology and Toxicology)

Depomed Announces Submission Of New Drug Application For Investigational Postherpetic Neuralgia Treatment DM-1796

Depomed, Inc. (NASDAQ: DEPO) announced that its licensee has submitted a New Drug Application (NDA) for DM-1796 to the U.S. Food and Drug Administration (FDA) for the management of postherpetic neuralgia (PHN), or pain after shingles. DM-1796 is an investigational, extended release, once-daily tablet formulation of gabapentin designed to reduce dosing frequency and have a low incidence of side effects. The application follows the completion of a randomized, double-blind, placebo-controlled Phase 3 study of 452 PHN patients... (Source: Health News from Medical News Today)<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>

Cluster Headache: Diagnosis and Treatment

Semin Neurol 2010; 30: 175-185DOI: 10.1055/s-0030-1249226ABSTRACTCluster headache is a rare yet exquisitely painful primary headache disorder occurring in either episodic or chronic patterns. The unique feature of cluster headache is the distinctive circadian and circannual periodicity in the episodic forms. The attacks are stereotypic&#8212;they are of extreme intensity and short duration, occur unilaterally, and are associated with robust signs and symptoms of autonomic dysfunction. Although the pathophysiology of cluster headache remains to be fully understood, there have been a number of recent seminal observations. To exclude structural mimics, patients presenting with symptoms suggestive of cluster headache warrant at least a brain magnetic resonance imaging (MRI) scan in their work-...

The rise and fall of gabapentin for bipolar disorder: a case study on off-label pharmaceutical diffusion

We examined the association&nbsp;of marketing, clinical trials and prior authorisation&nbsp;with gabapentin use. Setting and Patients: Florida Medicaid, bipolar disorder-diagnosed enrollees aged 18 to 64 for fiscal years 1994 to 2004. Results: Gabapentin prescriptions increased from 8/1000 enrollees per quarter in 1994 to a peak of 387/1000 enrollees in 2002. &nbsp;Its uptake tracked marketing efforts towards psychiatrists. &nbsp;The publication of 2 negative clinical trials in 2000 and the discontinuation of marketing expenditures towards psychiatrists were associated with an end to the steep rise ... (Source: NeLM - Mental Health)

Pfizer to pay $142M for drug fraud

Pharmaceutical giant Pfizer has been ordered to pay $142 million US in damages for fraudulently marketing gabapentin, an anti-seizure drug marketed under the name Neurontin. (Source: CBC | Health)

Gabapentin Does Not Reduce Preoperative Anxiety When Given Prior to Total Hip Arthroplasty

Conclusions. Administration of gabapentin 600 mg prior to surgery does not reduce preoperative anxiety. (Source: Pain Medicine)

Jury Rules Against Pfizer in Marketing Case

A federal jury decided against Pfizer in a case over its marketing of the epilepsy drug Neurontin and said the company must pay up to $141 million. (Source: WSJ.com: Health)<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>

Therapeutic Hotline: Treatment of prurigo nodularis and lichen simplex chronicus with gabapentin

Psychocutaneous conditions are frequently encountered in dermatology practice. Prurigo nodularis and lichen simplex chronicus are two frustrating conditions that are classified in this category. They are often refractory to classical treatment with topical corticosteroids and antihistamines. Severe, generalized exacerbations require systemic therapy. Phototherapy, erythromycine, retinoids, cyclosporine, azathiopurine, naltrexone, and psychopharmacologic agents (pimozide, selective serotonin reuptake inhibitor antidepressants) were tried with some success. Here five cases with lichen simplex chronicus and four cases with prurigo nodularis, who responded well to gabapentin, are presented. (Source: Dermatologic Therapy)

Chronic widespread pain and fibromyalgia syndrome

Abstract: Chronic widespread pain (CWP) and fibromyalgia syndrome (FMS) overlap with chronic fatigue syndrome (CFS). Several key tender trigger points are used to define FMS. Other symptoms reported commonly by patients with FMS include reduced pain threshold, fatigue, depression, anxiety, sleep disturbance, memory loss and problems with cognition, headache, migraine, diffuse abdominal pain with changes of bowel habit (irritable bowel syndrome) and urinary frequency. The pathogenesis of these syndromes is not clear but hyperexcitability of the central and peripheral nervous systems, changes in function of pain receptors, altered pain perception and somatization have all been hypothesized. There is functional magnetic resonance imaging evidence of altered pain processing in the fibromyalgia...

The anti-allodynic alpha(2)delta ligand pregabalin inhibits the trafficking of the calcium channel alpha(2)delta-1 subunit to presynaptic terminals in vivo.

Authors: Bauer CS, Rahman W, Tran-van-Minh A, Lujan R, Dickenson AH, Dolphin AC Neuropathic pain is caused by lesion or dysfunction of the peripheral sensory nervous system. Up-regulation of the voltage-gated Ca(2+) channel subunit alpha(2)delta-1 in DRG (dorsal root ganglion) neurons and the spinal cord correlates with the onset of neuropathic pain symptoms such as allodynia in several animal models of neuropathic pain. The clinically important anti-allodynic drugs gabapentin and pregabalin are alpha(2)delta-1 ligands, but how these drugs alleviate neuropathic pain is poorly understood. In the present paper, we review recent advances in our understanding of their molecular mechanisms. PMID: 20298215 [PubMed - in process] (Source: Biochemical Society Transactions)

Methamphetamine-induced up-regulation of [alpha]2/[delta] subunit of voltage-gated calcium channels is regulated by DA receptors

This study was carried out to determine the roles of dopamine D1 and D2 receptors on the up-regulation of [alpha]2/[delta] subunit of voltage-gated Ca2+ channels (VGCCs) induced by methamphetamine (METH). In the conditioned place preference paradigm, METH-induced place preference suppressed with gabapentin, an antagonist for [alpha]2/[delta] subunit. Under these conditions, the increase in [alpha]2/[delta] subunit expression was found in the frontal cortex and limbic forebrain. In addition, the METH-induced place preference was significantly attenuated by dopamine D1 and D2 receptor antagonists, SCH23390 and sulpiride, respectively. The expression of [alpha]2/[delta] subunit protein and its mRNA was significantly enhanced in the METH-treated cortical neurons. These increases in protein and...

Gabapentin and nortriptyline combined was better than either drug alone for relief of neuropathic pain.

Authors: PMID: 20231560 [PubMed - in process] (Source: Annals of Internal Medicine)<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>

Low-dose gabapentin as useful adjuvant to opioids for neuropathic cancer pain when combined with low-dose imipramine

Conclusion&nbsp;&nbsp;Low-dose gabapentin‚??antidepressant combination with opioids was effective in managing neuropathic cancer pain without severe adverse effects. Content Type Journal ArticleCategory Original ArticleDOI 10.1007/s00540-010-0913-6Authors Young-Chang P. Arai, Aichi Medical University Multidisciplinary Pain Centre, School of Medicine 21 Karimata, Nagakutecho Aichigun Aichi 480-1195 JapanTakako Matsubara, Aichi Medical University Multidisciplinary Pain Centre, School of Medicine 21 Karimata, Nagakutecho Aichigun Aichi 480-1195 JapanKazuhiro Shimo, Aichi Medical University Multidisciplinary Pain Centre, School of Medicine 21 Karimata, Nagakutecho Aichigun Aichi 480-1195 JapanKatsutoshi Suetomi, Aichi Medical University Multidisciplinary Pain Centre, School of Medi...

&#945;

Conclusion: These results indicate the effectiveness of a2d modulators for management of neuropathic pain secondary to compression radiculopathy. The results also suggest a possible therapeutic superiority of LYRICA over locally available generic brands of pregabalin and gabapentin. These findings need to be further examined in randomized, controlled trials. (Source: Indian Journal of Palliative Care)

A single dose of preoperative gabapentin for pain reduction and requirement of morphine after total mastectomy and axillary dissection: Randomized placebo-controlled double-blind trial

Conclusions : A single low dose of 600 mg gabapentin administered 1 h prior to surgery produced effective and significant postoperative analgesia after total mastectomy and axillary dissection without significant side effects. (Source: Journal of Postgraduate Medicine)

XenoPort Restructures to Focus on Key Programs

SANTA CLARA, Calif.--(HSMN NewsFeed)--XenoPort, Inc. (Nasdaq:XNPT ) announced today a restructuring that includes an overall reduction in its workforce of approximately 50%. The restructuring is designed to focus the Company¬?s resources on advancement of i... BiopharmaceuticalsXenoPort, Horizant, gabapentin, restless legs syndrome (Source: HSMN NewsFeed)

GABAPENTIN (Gabapentin) Capsule [Rebel Distributors Corp.]

Updated Date: Mar 5, 2010 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>

Sexuality and intimacy after gynecological cancer

Abstract: Matters of sexuality and intimacy greatly impact quality of life of patients with gynecologic cancers. Vast amount of evidence exists showing that cancer dramatically impacts woman's sexuality, sexual functioning, intimate relationships and sense of self. Sexual functioning can be affected by illness, pain, anxiety, anger, stressful circumstances and medications. There is a growing acknowledgement that these needs are not being appropriately addressed by providers.With improvements in early detection, surgery and adjuvant therapy for gynecologic cancer, long term survival and cure are becoming possible. Quality of life is thus becoming a major issue for patients. Patients suffer from hot flashes, difficulty sleeping, loss of libido and intimacy, all resulting in significant morbi...

N-antipyrine-3, 4-dichloromaleimide, an effective cyclic imide for the treatment of chronic pain: the role of the glutamatergic system.

CONCLUSION: These results provide strong evidence that NA-3,4-DCM produces antihypernociception in mice at peripheral, spinal, and supraspinal sites, and that interaction with the group I metabotropic glutamate receptors and NMDA receptors contributes to the mechanisms underlying its effect. PMID: 20185671 [PubMed - in process] (Source: Anesthesia and Analgesia)

The Role of Topiramate and other Anticonvulsants in the Treatment of Alcohol Dependence: a Clinical Review.

Authors: De Sousa A Alcohol dependence is a major health problem worldwide. Various pharmacological agents have been used in the management of alcohol dependence. This review looks at the role of topiramate and other anticonvulsants in the management of alcohol dependence. Topiramate is the most widely used anticonvulsant in the treatment of alcohol dependence. The literature on topiramate is reviewed and critically analyzed, along with its proposed mechanism of action in alcohol dependence. A review of data available on other anticonvulsants like carbamazepine, oxcarbazepine, sodium valproate, gabapentin and levetiracetam are presented and their potential in the treatment of alcohol dependence is considered, together with future research directions. PMID: 20201814 [PubMed - in pro...

Management of recurrent laryngeal sensory neuropathic symptoms.

CONCLUSIONS: Patients with suspected neuropathy of the recurrent laryngeal nerve frequently respond to neuromodulator therapy. The addition of reflux precautions and acid suppression therapy is helpful in cases of chronic and recurrent laryngospasm. Patients with evidence of motor neuropathy appear to have better outcomes with neuromodulator therapy. PMID: 20392032 [PubMed - in process] (Source: The Annals of Otology, Rhinology, and Laryngology)

[Coadjuvant analgesics for cancer pain: using the clinical queries PubMed tool.]

Authors: Chaparro G√?¬≥mez LE, Calvache Espa√?¬Īa JA, Arbel√?¬°ez Le√?¬≥n LM Coadjuvants for cancer pain are medications that, when added to opioids, can potentially decrease narcotic request and opioid-related side effects. Our goal was to review not only the evidence that supports the effectiveness, but also the mechanisms of action of these drugs. We performed a qualitative review using the PubMed database applying the clinical queries tool to identify therapeutic clinical trials or systematic reviews evaluating cancer pain--oral or transdermal--analgesia. We excluded studies using anti-inflammatories, steroids or narcotics as primary analgesia and studies focused on perioperative cancer pain. We supplemented the information describing the mechanisms of action and suggested dosage s...<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>

Focus on therapy: hemicrania continua and new daily persistent headache

Abstract&nbsp;&nbsp;Hemicrania continua (HC) and new daily-persistent headache (NDPH) represent the only two forms of chronic daily headache in Chap. IV ‚??Other Primary Headaches‚?Ě of the second edition of the International Classification of Headache Disorders. HC and NDPH are rare and poorly defined from a pathophysiological point of view; as a consequence, their management is largely empirical. Indeed, there is a lack of prospective, controlled trials in this field, and treatment effectiveness is basically inferred from the results of sparse open-label trials, retrospective case series, clinical experience and expert opinions. In this narrative review we have summarised the information collected from an extensive analysis of the literature on the treatment of HC and NDPH in order...

Anti-seizure drug promotion faces legal fire

A lawsuit over the anti-seizure drug Neurontin began in the U.S. on Monday, with patients, insurance companies and unions accusing the drug manufacturer of aggressively marketing it as pain medication. (Source: CBC | Health)

Video-assisted intercostal nerve cryoablation in managing intractable chest wall pain

A 52-year-old women was referred to our unit with severe pain in the right side of the chest, having been kicked in the right flank by a horse 10 years earlier. At the time she sustained fractures to the right 10th, 11th, and 12th ribs and briefly required hospitalization. The pain was sharp and stabbing in nature. Standard oral analgesia including nonsteroidal anti-inflammatory drugs was ineffective. She obtained little relief from opiates and was reluctant to take them long term. Some transient analgesia was obtained through epidurals and intercostal nerve blocks. She had been managed with gabapentin 800 mg twice daily and amitriptyline 25 mg daily long term. (Source: The Journal of Thoracic and Cardiovascular Surgery)

Gabapentin: Impaired driving: 4 case reports

(Source: Reactions)

Gabapentin/pregabalin: Myoclonus and confusion in a patient with chronic renal failure: case report

(Source: Reactions)<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>

Trigeminal trophic syndrome treated with thermoplastic occlusion

A 72-year-old man with a history of thrombotic CVA causing lateral medullary infarction presented with non-healing ulcers of the right side of the face of 5 months' duration. After extensive investigations, a diagnosis of trigeminal trophic syndrome was made. The ulcers progressed relentlessly despite amitriptyline and gabapentin, and he was treated with a combination of carbamazepine and thermoplastic mask occlusion of the right side of his face. Over the next 10 weeks the shallower facial ulcers began to diminish in depth and diameter, and the deeper ulcers stopped progressing. Although the patient showed early signs of healing, he died because of complications from the CVA. (Source: Australasian Journal of Dermatology)

GlaxoSmithKline And XenoPort Receive FDA Complete Response Letter For Horizant‚?Ę (GSK1838262/XP13512) For RLS

GlaxoSmithKline (NYSE: GSK) and XenoPort, Inc. (Nasdaq: XNPT) Wednesday received a Complete Response letter from the U.S. Food and Drug Administration (FDA) regarding the New Drug Application (NDA) for Horizant‚?Ę(gabapentin enacarbil) Extended-Release Tablets, an investigational non-dopaminergic treatment for moderate-to-severe primary Restless Legs Syndrome (RLS). A Complete Response letter is issued by the FDA's Center of Drug Evaluation and Research when the review of a file is completed and questions remain that preclude the approval of the NDA in its current form... (Source: Health News from Medical News Today)

GlaxoSmithKline and XenoPort receive FDA Complete Response letter for Horizant‚?Ę

GlaxoSmithKline (NYSE: GSK) and XenoPort, Inc. (Nasdaq: XNPT) received a Complete Response letter from the U.S. Food and Drug Administration (FDA) regarding the New Drug Application (NDA) for Horizant‚?Ę(gabapentin enacarbil) Extended-Release Tablets, an investigational non-dopaminergic treatment for moderate-to-severe primary Restless Legs Syndrome (RLS). (Source: World Pharma News)

GlaxoSmithKline And XenoPort Receive FDA Complete Response Letter For Horizant‚?Ę (GSK1838262/XP13512) For RLS

GlaxoSmithKline (NYSE:GSK) and XenoPort, Inc. (Nasdaq:XNPT) Wednesday received a Complete Response letter from the U.S. Food and Drug Administration (FDA) regarding the New Drug Application (NDA) for Horizant‚?Ę (gabapentin enacarbil) Extended-Release Tablets, an investigational non-dopaminergic treatment for moderate-to-severe primary Restless Legs Syndrome (RLS). A Complete Response letter is issued by the FDA's Center of Drug Evaluation and Research when the review of a file is completed and questions remain that preclude the approval of the NDA in its current form... (Source: Health News from Medical News Today)<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>

GlaxoSmithKline and XenoPort receive FDA Complete Response letter for Horizant‚?Ę (GSK1838262/XP13512) for RLS

GlaxoSmithKline and XenoPort, Inc. Wednesday received a Complete Response letter from the U.S. Food and Drug Administration (FDA) regarding the New Drug Application (NDA) for Horizant‚?Ę(gabapentin enacarbil) Extended-Release Tablets, an investigational non-dopaminergic treatment for moderate-to-severe primary Restless Legs Syndrome (RLS). (Source: GSK news)

Lacosamide intoxication in attempted suicide.

We report the clinical course of a patient with bitemporal epilepsy who ingested 12g of lacosamide, 56g of gabapentin, 2g of topiramate, and 2.8g of zonisamide during a suicide attempt. The patient was found comatose and experienced repeated generalized tonic-clonic seizures, aspiration with subsequent pneumonia, hypotension, and an increase in PR interval. Complete physical recovery occurred after several days of supportive treatment. We conclude that intoxication with lacosamide, in combination with overdoses of multiple AEDs, can be survived without sequelae, even after ingestion of 12g lacosamide. PMID: 20171144 [PubMed - as supplied by publisher] (Source: Epilepsy and Behaviour)

Chemical Composition and Evaluation of the Anti-Hypernociceptive Effect of the Essential Oil Extracted from the Leaves of Ugni myricoides on Inflammatory and Neuropathic Models of Pain in Mice

Planta MedDOI: 10.1055/s-0029-1240891AbstractThe study analyzes the chemical composition of the essential oil obtained from the leaves of (Kunth) O. Berg ( EO). The composition of the essential oil was characterized by GC&#8208;FID and GC&#8208;MS analysis, showing at least six major constituents: -pinene (52.1&#8202;%), 1,8-cineole (11.9&#8202;%), -humulene (4.6&#8202;%), caryophyllene oxide + globulol (4.5&#8202;%), humulene epoxide II (4.2&#8202;%) and -caryophyllene (2.9&#8202;%). It demonstrates for the first time the systemic anti-hypernociceptive properties of this orally administered oil in inflammatory and neuropathic models of hypernociception in mice. The effects of EO and its major constituent, -pinene, were compared with those of indomethacin or gabapentin, drugs used clinical...

Controlled-release oxycodone alone or combined with gabapentin for management of malignant neuropathic pain

Conclusion&nbsp;&nbsp;Malignant NP may be well controlled by oxycodone mono-therapy. Early combination with gabapentin is sensible when pain is not satisfactory relieved by oxycodone alone. The side effects of them are manageable. Content Type Journal ArticleCategory Original ArticleDOI 10.1007/s11670-010-0080-1Authors Xiao-mei Li, the Beijing Military General Hospital of PLA Department of Medical Oncology Beijing 100700 ChinaDuan-qi Liu, the Beijing Military General Hospital of PLA Department of Medical Oncology Beijing 100700 ChinaHang-yu Wu, the Beijing Military General Hospital of PLA Department of Medical Oncology Beijing 100700 ChinaChun Yang, Capital Medical University Department of Anatomy Beijing 100069 ChinaLi Yang, the Beijing Military General Hospital of PLA Departeme...

XenoPort Announces Extension of the Horizant PDUFA Date to February 11, 2010

SANTA CLARA, Calif.--(BUSINESS WIRE)--Feb 9, 2010 - XenoPort, Inc. announced today that the U.S. Food and Drug Administration (FDA) will not be taking an action today on the Horizant (gabapentin enacarbil) new drug application (NDA) for... (Source: Drugs.com - New Drug Applications)

Pregabalin in fibromyalgia: meta-analysis of efficacy and safety from company clinical trial reports

Source: Rheumatology Area: News According to the findings of a meta-analysis of clinical trial reports, pregabalin (Lyrica¬ģ) is effective in the treatment of certain patients with fibromyalgia (FM). &nbsp; Researchers studied data from five randomised trials (total n=3,808) of pregabalin in FM, using the company trial reports supplied by Pfizer (these provide more detailed information than published papers). A PubMed literature search revealed no additional randomised controlled trials.&nbsp; Data from four trials with standard design (double-blind, placebo-controlled) were pooled for meta-analysis (intention-to-treat). &nbsp; All participants were adults and met the ACR criteria for FM, with pain scores of ?40mm on the 100mm visual analogue scale (VAS) after stopping any relevan...

New Restless Leg Syndrome Review for XenoPort (XNPT, GSK)

XenoPort, Inc. (NASDAQ: XNPT) has a big day coming for its GSK1838262/XP13512 (gabapentin enacarbil) next week.  The company has a date of February 9 for an FDA Prescription Drug User Fee Act (PDUFA) decision on its Horizant. This is the dated  goal for the company&#8217;s New Drug Application for Horizant for the treatment of moderate-to-severe primary restless legs syndrome. Horizant is licensed to GlaxoSmithKline (NYSE: GSK) in the United States and several other countries. There is one concern here&#8230; The company&#8217;s release last week noted that the GaxoSmithKline partnership may be in doubt because Glaxo has noted that it may end research on depression and pain treatments.  GSK and XenoPort are discussing the next steps in the development plan for XP13512 in the neuropathic...

XenoPort Announces Horizant as Brand Name for XP13512

SANTA CLARA, Calif.--(BUSINESS WIRE)--Feb 4, 2010 - XenoPort, Inc. announced today that, subject to the approval of the U.S. Food and Drug Administration (FDA), the brand name for GSK1838262/XP13512 (gabapentin enacarbil) in the United States... (Source: Drugs.com - New Drug Applications)<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>

An Open Trial of Gabapentin in Acute Alcohol Withdrawal Using an Oral Loading Protocol

Conclusion: Oral 800 mg gabapentin (loaded up to 3200 mg in the first 24 h) is helpful only in reducing less severe and less complicated acute AWS. (Source: Alcohol and Alcoholism)

Post-traumatic stress disorder

New evidence; conclusions changed for: Fluoxetine to treat PTSD Two RCTs added found no significant difference between fluoxetine and placebo in PTSD symptoms at the end of treatment (8‚??12 weeks). One of the RCTs also found no significant difference between fluoxetine and placebo in the proportion of people no longer meeting diagnostic criteria for PTSD at the end of treatment. One RCT compared fluoxetine versus eye movement desensitisation and reprocessing (EMDR). It found no significant difference between treatments in PTSD symptoms at the end of treatment. However, EMDR was found to be more effective at sustaining improvement in symptoms at 6 months compared with fluoxetine. Evidence added at update suggests effects of fluoxetine in treating PTSD ar...

Depomed Announces Allowance Of U.S. Patent Covering Gastric Retentive Gabapentin Dosage Forms

Depomed, Inc. (NASDAQ:DEPO) announced that it has received a Notice of Allowance from the U.S. Patent and Trademark Office for a U.S. patent application (No. 12/239,591) directed to pharmaceutical dosage forms that deliver the compound gabapentin via Depomed's proprietary Acuform¬ģ gastric retentive drug delivery technology. Paul B. Simboli, Depomed's senior director of Intellectual Property, noted that with the issuance of this additional patent, Depomed will hold six U.S... (Source: Health News from Medical News Today)

Crossover trial of gabapentin and memantine as treatment for acquired nystagmus

We conducted a masked, crossover, therapeutic trial of gabapentin (1,200mg/day) versus memantine (40mg/day) for acquired nystagmus in 10 patients (aged 28-61 years; 7 female; 3 multiple sclerosis [MS]; 6 post-stroke; 1 post-traumatic). Nystagmus was pendular in 6 patients (4 oculopalatal tremor; 2 MS) and jerk upbeat, hemi-seesaw, torsional, or upbeat-diagonal in each of the others. For the group, both drugs reduced median eye speed (p < 0.001), gabapentin by 32.8% and memantine by 27.8%, and improved visual acuity (p < 0.05). Each patient improved with 1 or both drugs. Side effects included unsteadiness with gabapentin and lethargy with memantine. Both drugs should be considered as treatment for acquired forms of nystagmus. ANN NEUROL 2010;67:676-680 (Source: Annals of Neurology)

What non-hormonal alternatives to antidepressants are available for the management of menopausal hot flushes?

Source: Wessex Drug and Medicines Information Centre Area: Evidence > Medicines Q & A .&nbsp;To help reduce hot flushes, women should be encouraged to take regular exercise, reduce stress and wear lighter clothing. Any trigger factors should be avoided. &nbsp; .&nbsp;Clonidine is the only non-oestrogen based preparation that is licensed for menopausal flushing, but its use is limited by moderate efficacy and relatively high rate of adverse effects. &nbsp; .&nbsp;Studies have also been conducted using gabapentin, methyldopa and octreotide, which have produced variable results. &nbsp; .&nbsp;One small meta-analysis has suggested that gabapentin at a dose of 300mg three times daily may be effective but its use should be restricted to specialist centres. &nbsp; .&nbsp;Most of ...<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>

Diagnosis and Treatment of Osteoarthritis

Osteoarthritis (OA) is a common disease in aging dogs and cats but frequently goes undiagnosed and untreated. Although OA cannot be cured, long-term management of the disease can be very rewarding for the veterinary medical team as well as pet owners. Managing pain with pain medications is an essential first step. There are a wealth of pain medications available, including nonsteroidal antiinflammatory drugs, gabapentin, amantadine, and tramadol. There are also physical modalities available for pain reduction. Weight management and nutritional joint support are also important in aspects of managing OA in dogs and cats. Finally, physical rehabilitation is a great way to improve mobility and keep pets active as they age. (Source: Topics in Companion Animal Medicine)

Pharmacokinetics and Pharmacodynamics of Gabapentin in Horses: A Potentially Useful Analgesic Agent for the Treatment of Laminitis

Gabapentin (20 mg/kg) caused no major adverse effects in normal horses. Although the oral bioavailability is low, gabapentin is worthy of evaluation as an analgesic therapy for laminitis. (Source: Journal of Equine Veterinary Science)

Pruritus: control of itch in patients undergoing dialysis.

Authors: Mettang M, Weisshaar E Chronic kidney disease (CKD)-associated pruritus is a significant clinical symptom affecting more than 50% of patients on hemodialysis. Restricted by the availability of effective therapeutic options, the management of CKD-associated pruritus remains a treatment challenge. Evaluating research in this area is difficult, as most studies are not comparable due to differing methodologies and study designs, limited number of patients, and the lack of standardized measures. The most frequently used therapy is UVB phototherapy, eliciting favorable responses in most patients. Newer approaches, such as treatment with the m-opiod-receptor antagonist, naltrexone, have yielded conflicting results. The use of the k-opioid-receptor-agonist, nalfurafine, appears to be ...

Gabapentin (Neurontin¬ģ) improves pain scores of patients with critical limb ischaemia: An observational study

Conclusions: The study has demonstrated that gabapentin is a useful adjuvant in the management of CLI and leads to significant reductions in pain scores and improves night pain for most patients. (Source: International Journal of Surgery)

Pharmacological approaches to methamphetamine dependence: a focused review

Methamphetamine dependence is a serious worldwide public health problem with major medical, psychiatric, socioeconomic and legal consequences. Various neuronal mechanisms implicated in methamphetamine dependence have suggested several pharmacological approaches. A literature search from a range of electronic databases (PubMed, EMBASE, PsycInfo, the NIDA research monograph index and the reference list of clinicaltrials.gov) was conducted for the period from January 1985 to October 2009. There were no restrictions on the identification or inclusion of studies in terms of publication status, language and design type. A variety of medications have failed to show efficacy in clinical trials, including a dopamine partial agonist (aripiprazole), GABAergic agents (gabapentin) and serotonergic agen...<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>

Focus on therapy of primary stabbing headache

In this report, we focus on the therapy of PSH summarizing the information collected from a systematic analysis of the international literature over the period 1980‚??2009. Content Type Journal ArticleCategory TutorialDOI 10.1007/s10194-010-0189-0Authors Enrico Ferrante, Niguarda Ca‚?? Granda Hospital Department of Neuroscience Milan ItalyPaolo Rossi, Headache Clinic INI Grottaferrata Rome ItalyCristina Tassorelli, IRCCS ‚??Neurological Institute C. Mondino‚?Ě Foundation, University Centre for Headache and Adaptive Disorders (UCADH), University of Pavia Headache Science Centre Pavia ItalyCarlo Lisotto, S. Vito al Tagliamento Hospital Department of Neuroscience, Headache Centre Pordenone ItalyGiuseppe Nappi, IRCCS ‚??Neurological Institute C. Mondino‚?Ě Foundation, University Centre f...

Cardiopulmonary bypass does not affect plasma concentration of preoperatively administered gabapentin.

CONCLUSION: Plasma gabapentin concentration is unaltered during CPB following preoperative administration. Drug accumulation following third and fourth postoperative doses suggests the need for therapeutic drug monitoring in future trials. Gabapentin is well established as an effective adjunct analgesic in a number of surgical settings. Randomized controlled trials are necessary to evaluate analgesic efficacy, optimal dosing, and adverse effects in the setting of cardiac surgery. (ClinicalTrials.gov number, NCT01022736). PMID: 20112079 [PubMed - as supplied by publisher] (Source: Canadian Journal of Anaesthesia)

Phase III, Randomized, Double-Blind, Placebo-Controlled Evaluation of Pregabalin for Alleviating Hot Flashes, N07C1 [Palliative and Supportive Care]

Conclusion Pregabalin decreases hot flashes and is reasonably well tolerated. A target dose of 75 mg twice daily is recommended. Its effects appear to be roughly comparable to what has been reported with gabapentin and with some newer antidepressants. (Source: Journal of Clinical Oncology)

Searching for novel crystal forms by in situ high-pressure crystallisation: the example of gabapentin heptahydrate

Francesca P. A. Fabbiani, Demetrius C. Levendis, Gernot Buth, Werner F. Kuhs, Norman Shankland, Heidrun Sowa (Paper from CrystEngComm) Francesca P. A. Fabbiani, CrystEngComm, 2010, DOI: 10.1039/b924573a To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - CrystEngComm latest articles)

Substitution of Gabapentin Therapy with Pregabalin Therapy in Neuropathic Pain due to Peripheral Neuropathy

Conclusions. Randomized, controlled, blinded head-to-head studies of GBP and PGB have not been published. The results of this open-label assessment of PGB substitution for GBP suggest that PGB may provide additional pain relief and possible improvement in quality of life above that received by GBP use in patients with NeP due to PN. (Source: Pain Medicine)<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>

Depomed Comments On FDA Guidance And Plans For One Additional Phase 3 Clinical Trial Evaluating Non-Hormonal Therapy For Menopausal Hot Flashes

Depomed, Inc. (NASDAQ:DEPO) announced it has received guidance from the FDA in formal meeting minutes from a meeting held in December regarding SeradaTM, the company's extended release gabapentin product candidate for the treatment of menopausal hot flashes. Based on guidance reflected in the meeting minutes, Depomed plans to conduct a single additional pivotal Phase 3 trial evaluating Serada for the treatment of menopausal hot flashes... (Source: Health News from Medical News Today)

Treatments for neuropathic pain differentially affect delayed matching accuracy by macaques: Effects of amitriptyline and gabapentin

Abstract: Current clinical treatments for neuropathic pain include amitriptyline, a tricyclic antidepressant with mixed pharmacology that is also clinically reported to impair cognitive performance; and gabapentin, a compound that selectively interacts with őĪ2őī-1 calcium channel subunits. Since few assessments of cognitive performance have been made in non-human primates with these marketed treatments, the purpose of this study was to determine their relative abilities to alter working memory as measured in mature macaques in their performance of a delayed matching-to-sample task. Four delay intervals of increasing duration provided increasing impairment in task accuracies during vehicle sessions. Administration of clinically relevant doses of amitriptyline significantly decreased task a...

Clinical pharmacokinetic drug interaction studies of gabapentin enacarbil, a novel transported prodrug of gabapentin, with naproxen and cimetidine

CONCLUSIONS No gabapentin enacarbil dose adjustment is needed with co-administration of naproxen or cimetidine. (Source: British Journal of Clinical Pharmacology)

Tri-partite complex for axonal transport drug delivery achieves pharmacological effect

Conclusion: Specific targeting of selected subpopulations of CNS neurons for drug delivery by axonal transport holds great promise. The data shown here provide a basic framework for the intraneural pharmacology of this tripartite complex. The pharmacologically efficacious drug delivery demonstrated here verify the fundamental feasibility of using axonal transport for targeted drug delivery. (Source: BMC Neuroscience - Latest articles)

Epicrania Fugax: Ten New Cases and Therapeutic Results

Conclusions.[mdash] This description reinforces the proposal of EF as a new headache variant or a new headache syndrome. Anesthetic blockades, carbamazepine, gabapentin, and lamotrigine have been apparently effective in individual patients. Further observations and therapeutic trials are needed. (Source: Headache: The Journal of Head and Face Pain)<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>

Epicrania Fugax: Ten New Cases and Therapeutic Results.

Conclusions.- This description reinforces the proposal of EF as a new headache variant or a new headache syndrome. Anesthetic blockades, carbamazepine, gabapentin, and lamotrigine have been apparently effective in individual patients. Further observations and therapeutic trials are needed. PMID: 20100299 [PubMed - as supplied by publisher] (Source: Headache)

What can be done about hot flushes after treatment for breast cancer?

Authors: Kontos M, Agbaje OF, Rymer J, Fentiman IS Breast cancer survivors frequently experience severe hot flushes as a result of their treatment. This can adversely affect their quality of life, compliance with treatment and overall survival. To relieve vasomotor symptoms, a variety of drugs have been used including clonidine, gabapentin, selective serotonin reuptake inhibitors and selective norepinephrine reuptake inhibitors. Stellate ganglion block (SGB) has recently emerged as a new technique against hot flushes and preliminary studies report encouraging efficacy with minimal complications. Other approaches include various alternative treatments and, in a few cases, hormone replacement therapy (HRT). All randomized, controlled studies of drugs, hormone treatments and alternative t...

Exploring differential prescribing between anti-epileptic drugs in epilepsy patients with a history of mood disorders

To explore differential prescribing of anti-epileptic drugs (AEDs) to patients with epilepsy by history of mood disorder.Epilepsy was defined as at least one diagnosis code and one AED prescription, and all patients must have been on the database 182 days before and after their first AED prescription. The Integrated HealthCare Information Services (IHCIS) insurance claims database included 44 557 patients with epilepsy between January 1997 and March 2007. The General Practice Research Database (GPRD) included 16 904 patients with epilepsy up to March 2007. Patients were categorized by their first use of specified AEDs. Mood disorders were defined as diagnosis codes for depression and bipolar disorder, or anti-depressant use. The unadjusted odds ratios and 95% confidence intervals for a his...

A single dose of preoperative gabapentin for pain reduction and requirement of morphine after total mastectomy and axillary dissection: Randomized placebo-controlled double-blind trial

Conclusions : A single low dose of 600 mg gabapentin administered 1 h prior to surgery produced effective and significant postoperative analgesia after total mastectomy and axillary dissection without significant side effects. (Source: Journal of Postgraduate Medicine)

A prospective open-label trial of gabapentin as an adjuvant analgesic with opioids for Japanese patients with neuropathic cancer pain

Conclusion&nbsp;&nbsp;Although gabapentin might be regarded as a promising new adjuvant analgesic for neuropathic cancer pain, our results indicated that the decrease in pain score was of minimal clinical benefit. Controlled trials with other adjuvant analgesics are needed. Content Type Journal ArticleCategory Original ArticleDOI 10.1007/s10147-009-0009-1Authors Hidenori Takahashi, Shin Zushi Clinic 6-5-4 Zushi Zushi Kanagawa 249-0006 JapanNaohito Shimoyama, National Cancer Center Hospital Department of Anesthesiology and Palliative Care 5-1-1 Tsukiji, Tyuo-ku Tokyo 104-0045 Japan Journal International Journal of Clinical OncologyOnline ISSN 1437-7772Print ISSN 1341-9625 (Source: International Journal of Clinical Oncology)<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>

Novel long-term anticonvulsant treatment with gabapentin without causing memory impairment in mice.

Authors: Blake MG, Boccia MM, Carcaboso AM, Chiappetta DA, H&#xF6;cht C, Krawczyk MC, Sosnik A, Baratti CM We previously reported that administration of a single dose of gabapentin (GBP) immediately after training improves memory of mice in an inhibitory avoidance task (IA), whereas GBP administered repeatedly for 7days impairs memory. This is in accordance with the observation that long-term clinical treatment with GBP may be associated with adverse cognitive side effects. In the present work we used a GBP-loaded poly(epsilon-caprolactone) implant, allowing controlled release of the drug and maintenance of constant plasma levels over 1week. When GBP-loaded implants were inserted subcutaneously into mice, immediately after training in the IA task, memory consolidation was enhanced. Mor...

A case of rheumatoid arthritis presenting with postherpetic neuralgia and abdominal-wall pseudohernia

We report a patient &gt;45&nbsp;years of age with a history of rheumatoid arthritis (RA) who presented with two chronic HZ complications. A 75-year-old woman was admitted with neuralgia following cutaneous herpes zoster 6&nbsp;weeks before. She was on long-term glucocorticoid, antimalarial and non-steroidal anti-inflammatory treatment. Confluent ulcers began to fill with granulation tissue, crusts, scars and skin discoloration in the area of the left T12-L2 dermatomes and reducible, painless swelling of the left flank, 20&nbsp;√?&nbsp;20&nbsp;cm, without palpable defect in abdominal-wall. There were typical joint deformity and positive rheumatoid factor. On neurological examination superficial abdominal reflexes were diminished in the left side, with hypesthesia of the overlying skin...

Potentiation of the anticonvulsant efficacy of sodium channel inhibitors by an NK1-receptor antagonist in the rat

Discussion: These results suggest that there may be benefit in adding treatment with a suitable NK1-receptor antagonist to treatment with a sodium channel blocker in patients with refractory epilepsy. (Source: Epilepsia)

Treatment of complex regional pain syndrome: a review of the evidence.

CONCLUSIONS: Published RCTs can only provide limited evidence to formulate recommendations for treatment of CRPS. In this review, no study was excluded based on factors such as sample size justification, statistical power, blinding, definition of intervention allocation, or clinical outcomes. Thus, evidence derived from "weaker" trials may be overemphasized. Further well-designed RCTs are warranted. PMID: 20054678 [PubMed - as supplied by publisher] (Source: Canadian Journal of Anaesthesia)

Effects of Single-Dose Gabapentin on Postoperative Pain and Morphine Consumption After Cardiac Surgery

Conclusions: Oral GABA at a dose of 600 mg given before cardiac surgery significantly reduced postoperative morphine consumption and postoperative pain both at rest and with cough. (Source: Journal of Cardiothoracic and Vascular Anesthesia)<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>

NEURONTIN (Gabapentin) Capsule NEURONTIN (Gabapentin) Tablet, Film Coated NEURONTIN (Gabapentin) Suspension [Parke-Davis Div Of Pfizer Inc]

Updated Date: Jan 6, 2010 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

Comparative placebo-controlled polysomnographic and psychometric studies on the acute effects of gabapentin versus ropinirole in restless legs syndrome

In conclusion, the dopamine agonist ROP showed acute therapeutic efficacy with regard to PLM measures only, whereas GBT had a less pronounced effect on these measures, but improved objective and subjective sleep and awakening quality as compared with both placebo and ROP. Differential acute drug effects may serve as prognostic indicators of therapeutic response of individual patients. Content Type Journal ArticleCategory Movement Disorders - Original ArticleDOI 10.1007/s00702-009-0361-3Authors Michael Saletu, Medical University of Vienna Department of Psychiatry and Psychotherapy W√§hringer G√ľrtel 18-20 1090 Vienna AustriaPeter Anderer, Medical University of Vienna Department of Psychiatry and Psychotherapy W√§hringer G√ľrtel 18-20 1090 Vienna AustriaGerda Maria Saletu-Zyhlarz, Me...

Gabapentin use in hyperemesis gravidarum: A pilot study

Abstract: Among 7 subjects with hyperemesis gravidarum (HG), we found gabapentin therapy to be associated with mean reductions in nausea and emesis from Baseline to Days 12‚??14 of 80% and 94%, respectively. There have been 2 congenital defects among 7 exposed infants. Gabapentin may be effective in the treatment of HG. (Source: Early Human Development)

[Therapeutic drug monitoring of gabapentin]

Authors: Tribut O, Bentu√?¬©-Ferrer D, Verdier MC, Gabapentin is a structural analogue of GABA used in the treatment of the partial epilepsies of adult and child of more than 12 years, in monotherapy or in association with other anticonvulsant drugs. In association, gabapentin presents the advantage of not interfering with the other anticonvulsant drugs. The interindividual pharmacokinetic variability and the saturable absorption are, with the adaptation in case of renal insufficiency, the only arguments in favor of TDM. During clinical studies, the plasma concentrations of gabapentin were generally included between 2 and 20 mg/L. For this molecule, the level of proof of the interest of therapeutic drug monitoring was estimated in: possibly useful. PMID: 20205997 [PubMed - indexed...

Gabapentin for the treatment of pain syndrome related to radiation‚?źinduced mucositis in patients with head and neck cancer treated with concurrent chemoradiotherapy

Abstract (Source: Cancer)<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>

Gabapentin and suicide attempts

Abstract (Source: Pharmacoepidemiology and Drug Safety)

Amelioration of Oxaliplatin Neurotoxicity by Drugs in Humans and Experimental Animals: A MiniReview of Recent Literature

Abstract: The broad spectrum anti-neoplastic drug oxaliplatin is a third-generation platinum compound that inhibits DNA synthesis, mainly by causing intrastrandal cross-links in DNA. The drug is particularly useful alone and in combination with flurouracil and leucovorin in colorectal cancer, but it is also used for other cancers such as those of the ovary, lung, breast and liver, as well as non-Hodgkin's lymphoma. The drug is known to cause neurological, gastrointestinal and haematological toxicities. Neurotoxicity occurs in most of the treated patients and is considered to be a serious limitation for the use of the drug. The mechanism of the neurotoxicity is not known with certainty but may involve prolongation of sodium channels opening. Strategies to ameliorate oxaliplatin neurotoxicit...

Neuronal hyperactivity at the spinal cord and periaqueductal grey during painful diabetic neuropathy: Effects of gabapentin

Abstract: Painful diabetic neuropathy may be due to impairments in descending modulation of nociceptive transmission at the spinal cord. In the present study, streptozotocin diabetic rats (STZ rats) with neuropathic symptoms (mechanical hypersensitivity) were used to perform a time-course evaluation of neuronal activity at the spinal dorsal horn and at the periaqueductal grey matter (PAG), a major brainstem area of pain modulation. The expression of Fos protein, a marker of nociceptive activation, progressively increased at the spinal dorsal horn at 4 and 10weeks. At the PAG, increases in Fos expression were detected until the 4th week, with a reversal to baseline values at 10weeks in all areas except the ventrolateral PAG. Co-localisation of Fos with NeuN ascertained the neuronal nature o...

Optimizing Emetic Control in Children Receiving Antineoplastic Therapy: Beyond the Guidelines.

Authors: Dupuis LL, Nathan PC Existing guidelines for the prevention of antineoplastic chemotherapy-induced nausea and vomiting (CINV) in children are constrained by the lack of robust evidence. Current guidelines recommend the use of a serotonin 5-HT(3) receptor antagonist plus a corticosteroid to prevent acute CINV. Consequently, antiemetic agents that are recommended for use in adult cancer patients do not appear in the current pediatric guidelines. In addition, there is no information to guide the selection of alternative antiemetic agents for children who either cannot receive the recommended agents or who do not respond adequately to the treatment. Possible barriers to adherence to the pediatric antiemetic selection guidelines that are currently available are discussed, and publi...

&#945;&lt;sub&gt;2&lt;/sub&gt;&#948; Modulators for management of compression neuropathic pain: A review of three case series

Conclusion: &#x0026;lt;/b&#x0026;gt; These results indicate the effectiveness of a&#x0026;lt;sub&#x0026;gt;2&#x0026;lt;/sub&#x0026;gt;d modulators for management of neuropathic pain secondary to compression radiculopathy. The results also suggest a possible therapeutic superiority of LYRICA over locally available generic brands of pregabalin and gabapentin. These findings need to be further examined in randomized, controlled trials. (Source: Indian Journal of Palliative Care)<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>

Bone and calcium metabolism and antiepileptic drugs

Abstract: There is increasing evidence suggesting that epilepsy and its treatment can affect bone mineralization and calcium metabolism. Many studies have shown a significant reduction in bone mineral density in patients treated with classic (phenobarbital, carbamazepine, valproate, etc.) and with new (oxcarbazepine, gabapentin) antiepileptic drugs. In spite of data about the possible effects of the antiepileptic drugs on calcium metabolism, the mechanisms of this important side effect remain to be defined. The abnormalities of calcium metabolism were thought to result from the cytochrome P450 enzyme-inducing properties of some antiepileptic drugs and the resultant reduction in vitamin D levels, but the effect of many medications (e.g., valproate) cannot be readily explained by vitamin D m...

Gabapentin-lactum‚??chloranilic acid (1/1)

In the title compound, C9H15NO¬∑C6H2Cl2O4 [sytematic name: 2-azaspiro[4.5]decan-3-one‚??chloranilic acid (1/1)], the cyclohexane ring of the lactam molecule adopts a slightly distorted normal chair conformation and the five-membered 3-azaspiro ring is in a slightly distorted chair conformation. The dihedral angle between the least-squares planes of the cyclohexane and 3-azaspiro rings is 84.0‚??(3)¬į. In the crystal, the chloranilic acid molecule and the gabapentin-lactum molecules are held together by strong intermolecular N‚??H...O and O‚??H...O hydrogen bonds with two bifurcated O acceptor atoms on the chloranilic acid molecule and one on the gabapentin-lactum molecule, each bonding with an inter- and intramolecular hydrogen bond. The molecules are linked into chains parallel to (011) a...

Fast Track Liver Resection: The Effect of a Comprehensive Care Package and Analgesia with Single Dose Intrathecal Morphine with Gabapentin or Continuous Epidural Analgesia

Conclusions. Single dose intrathecal morphine is a safe and effective means of providing peri-operative analgesia. Patients managed with intrathecal morphine have reduced peri-operative physiological disturbance and return home within a few days of hepatic resection. (Source: HPB Surgery)

Gabapentin: Fixed drug eruption: case report

(Source: Reactions)

Is Anticonvulsant Treatment of Mania a Class Effect? Data from Randomized Clinical Trials.

Authors: Rosa AR, Fountoulakis K, Siamouli M, Gonda X, Vieta E Our aim was to evaluate the efficacy and tolerability of anticonvulsant agents for the treatment of acute bipolar mania and ascertain if their effects on mania are a "class" effect. We conducted a systematic review of randomized controlled trials (RCTs) with placebo or active comparator, in acute bipolar mania in order to summarize available data on anticonvulsant treatment of mania/mixed episodes. We searched (PubMed/MEDLINE) with the combination of the words "acute mania" and "clinical trials" with each one of the following words: "anticonvulsants/antiepileptics,""valproic/valproate/divalproex,""carbamazepine,""oxcarbazepine,""lamotrigine,""gabapentin,""topiramate,""phenytoin,""zonisamide,""retigabine,""pregabalin,""tiaga...<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>

Single dose of preoperative analgesia with gabapentin (600 mg) is safe and effective in monitored anesthesia care for nasal surgery

This study was aimed to compare the intraoperative sedative and perioperative analgesic drug requirements and the incidences of postoperative side effects on the patients who received preoperative gabapentin or placebo. Sixty patients undergoing nasal septal or nasal sinus surgery were included. The patients received either 600&nbsp;mg gabapentin (Group G) or placebo (Group P) orally, 1&nbsp;h before surgery. The scores for sedation and pain were recorded at 5, 15, 30, 45 and 60&nbsp;min, intraoperatively and at 30&nbsp;min, 1, 2, 4, 6, 9, 12, 16, 20, 24&nbsp;h, postoperatively. Sedation was achieved with an IV bolus of propofol and continuous infusion of remifentanil. There were significant differences between gabapentin and placebo groups with regard to total consumptions of remife...

Single dose of preoperative analgesia with gabapentin (600 mg) is safe and effective in monitored anesthesia care for nasal surgery

This study was aimed to compare the intraoperative sedative and perioperative analgesic drug requirements and the incidences of postoperative side effects on the patients who received preoperative gabapentin or placebo. Sixty patients undergoing nasal septal or nasal sinus surgery were included. The patients received either 600&nbsp;mg gabapentin (Group G) or placebo (Group P) orally, 1&nbsp;h before surgery. The scores for sedation and pain were recorded at 5, 15, 30, 45 and 60&nbsp;min, intraoperatively and at 30&nbsp;min, 1, 2, 4, 6, 9, 12, 16, 20, 24&nbsp;h, postoperatively. Sedation was achieved with an IV bolus of propofol and continuous infusion of remifentanil. There were significant differences between gabapentin and placebo groups with regard to total consumptions of remife...

Modulatory effects of neuropsychopharmaca on intracellular pH of hippocampal neurones in vitro

Conclusion and implications: These data substantiate the view that clinically relevant concentrations of neuroleptics and antidepressants can mediate changes in neuronal pHi, which may contribute to their pharmacological mode of action. Effects on pHi should be taken into account when therapeutic or even harmful effects of these drugs are evaluated. (Source: British Journal of Pharmacology)

Gabapentin and Superior Oblique Myokymia

(Source: Neuro-Ophthalmology)

Effects of Preoperative Gabapentin on Postoperative Nausea and Vomiting after Open Cholecystectomy: A Prospective Randomized Double-Blind Placebo-Controlled Study

Med Princ Pract 2010;19:57-60 (DOI:10.1159/000252836) (Source: Medical Principles and Practice : Last 20 articles)<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>

GABAPENTIN (Gabapentin) Tablet, Film Coated [Rebel Distributors Corp.]

Updated Date: Dec 8, 2009 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

Gabapentin: Chorea in an elderly patient: case report

(Source: Reactions)

Modality of hyperalgesia tested, not type of nerve damage, predicts pharmacological sensitivity in rat models of neuropathic pain

Abstract: Although many types of nerve damage can cause neuropathic pain, there are substantial commonalities in neuropathic pain symptoms, and patients can be divided into sub-groups based on their symptom profile rather than etiology. Mechanism-based treatment suggests that pharmacotherapy should be chosen be based shared commonalities of symptoms rather than etiology. The aim of the present study was to determine whether type of injury (etiology) or behavioral endpoint (symptom) is a better predictor of pharmacological responsivity in the most commonly used rodent models of neuropathic pain. We used the chronic constriction injury (CCI) model to directly compare the temporal and pharmacological characteristics of four different types of evoked stimuli; heat, pressure, acetone cooling an...

Outcome reporting in industry-sponsored trials of gabapentin for off-label use

N Engl J Med 2009;361:1963-71 (Source: Palliative Care JournalClub - Selected Articles)

Gabapentin decreases morphine consumption and improves functional recovery following total knee arthroplasty

Background: Moderate to severe pain after total knee arthroplasty often interferes with postoperative rehabilitation and delays discharge from hospital. The present study examined the effects of a 4-day postoperative gabapentin (GBP) regimen versus placebo on opioid consumption, pain scores and knee flexion, as well as adverse effects, after total knee arthroplasty. (Source: Acute Pain)<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>

Gabapentin versus tricyclic antidepressants for diabetic neuropathy and post-herpetic neuralgia: discrepancies between direct and indirect meta-analyses of randomized controlled trials

Source: DARE Area: Evidence > Disease Focused Reviews CRD Summary: This review concluded that there was no difference in pain relief between gabapentin and tricyclic antidepressants in patients with diabetic neuropathy or post-herpetic neuralgia, although direct evidence was limited. The review was well conducted and these findings are likely to be reliable. [Tricyclic antidepressants evaluated included nortriptyline, amitriptyline, desipramine, imipramine and&nbsp;clomipramine. ] CRD Commentary: The review addressed a focused question supported by clearly defined inclusion criteria. The literature search was limited to two electronic databases and some attempts were made to minimise publication bias; the potential for this was assessed and some evidence was found for tricyclic studie...

Gabapentin decreases morphine consumption and improves functional recovery following total knee arthroplasty

Background: Moderate to severe pain after total knee arthroplasty often interferes with postoperative rehabilitation and delays discharge from hospital. The present study examined the effects of a 4-day postoperative gabapentin (GBP) regimen versus placebo on opioid consumption, pain scores and knee flexion, as well as adverse effects, after total knee arthroplasty. (Source: Acute Pain)

The long-term retention of pregabalin in a large cohort of patients with epilepsy at a tertiary referral centre

Summary: Pregabalin (PGB) is a new antiepileptic drug (AED) which is a structural, non-functional analogue of gamma-aminobutyric acid. It acts at presynaptic calcium channels to modulate neurotransmitter release in the CNS. While the efficacy and tolerability of PGB have been demonstrated in several randomised controlled trials, few studies have addressed long-term outcome in large groups of patients.A cohort of patients attending a tertiary referral centre for epilepsy was identified as having started taking PGB. Patients‚?? data were obtained through medical records. Of 402 patients included, 42% of patients were still taking PGB at last follow-up. The estimated 2.5-year retention rate was 32%. Males appeared more likely to continue on PGB therapy than females. The common adverse experie...

Investigators Point to Unethical Reporting in Gabapentin Studies

Internal company documents obtained during litigation suggest Pfizer influenced outcomes in published trials, report researchers. Medscape Medical News (Source: Medscape Today Headlines)

Gabapentin in carpal tunnel patients: A consideration

Wiwanitkit VirojNeurology India 2009 57(5):690-690 (Source: Neurology India)<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>

Managing hot flushes in men after prostate cancer‚??A systematic review

Conclusion: Hot flushes are common and bothersome symptoms in men with prostate cancer and those taking anti-androgen treatment, and reduce quality of life. Few treatments are available and some are avoided for these patients. Additional prospective treatment studies are needed, with long-term follow-up, in order to evaluate the effects and risks of treatments. Treatments with few or no severe side-effects should be prioritised in future investigations. Experimental studies are also needed to elucidate the mechanism behind hot flushes in men and to suggest routes for the development of new treatments. (Source: Maturitas)

Notalgia paresthesica successfully treated with narrow-band UVB: report of five cases

Conclusion Given the benefits achieved, we stress the interest of UVB narrow-band as a safe and well tolerated alternative treatment for notalgia paresthetica. (Source: Journal of the European Academy of Dermatology and Venereology)

One son‚??s story: Getting to know my father thanks to advances in epilepsy medication

Steve Coldwell and his father, Stephen, in 1974 When I think of my father‚??s epilepsy, I always go back to a seizure he had during one of my Boy Scout camping trips. It wasn‚??t the first time I saw my dad have an epileptic seizure, but it was the first time I was the only member of our family around to deal with it. We were playing softball and he was at bat. After a pitch or two went past him, he simply let the bat fall to the ground and sat down on home plate. I immediately knew he was having a seizure, so I helped him up, walked him off the field and talked to him until he came back around. When my mother heard about it later, she was upset, asking why I hadn‚??t called her after it happened. I told her there was no point. It wasn‚??t like I had never seen my father have a seizure; t...

Off-Label Gabapentin Trial Outcome Reporting Examined, Inclusion of Protocols in Trial Registration Recommended

A study by researchers at the Johns Hopkins Bloomberg School of Public Health identified evidence of selective outcome reporting for clinical trials of off-label use of the seizure medication, gabapentin. The analysis compared study protocols for off-label use and the manufacturer s internal research reporting with published reports of study findings. The results are published in the November 12 edition of the New England Journal of Medicine. (Source: Public Health News Headlines from Johns Hopkins)

Analysis of the antinociceptive interactions in two-drug combinations of gabapentin, oxcarbazepine and amitriptyline in streptozotocin-induced diabetic mice.

We examined the effects of two-drug combinations of gabapentin, oxcarbazepine, and amitriptyline on nociception in diabetic mice and aimed to determine the type of interaction between components. The nociceptive responses in normal and diabetic mice were assessed by the tail-flick test. The testing was performed before and three weeks after the diabetes induction with streptozotocin (150mg/kg; i.p.), when the antinociceptive effects of gabapentin, oxcarbazepine, amitriptyline and their two-drug combinations were examined. Gabapentin (10-40mg/kg; p.o.) and oxcarbazepine (20-80mg/kg; p.o.) produced a significant, dose-dependent antinociception in diabetic mice while amitriptyline (5-60mg/kg; p.o.) produced weak antinociceptive effect. In normal mice, neither of the drugs produced antinocicep...<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>

Who Can We Trust?

Neurontin might not be a drug for sexual problems, but this week's controversy surrounding it speaks volumes for the concerns I have about a number of the drug studies that I read in medical journals. These are journals I should be able to trust, but trust does not always run deep when so much of a journal's revenue comes from the big glossy ads that the drug companies place in them.It's also difficult to feel trust when so many of the "unbiased" journal studies list authors who are employees of the drug companies. But even before the studies had to list the ringers from big pharm, I would often scratch my head thinking "Why did the authors ignore this?" or "Why did they create their own instrument to measure the results when others already exist?" I have often wondered if they didn't hire...

Published evidence for off-label gabapentin uses is incomplete

Source: NEJM Area: News A comparison of the published evidence for off-label uses of gabapentin with reports available to the manufacturer found significant discrepancies in outcome reporting and unpublished negative trials. &nbsp; There is substantial evidence that selective and biased outcome reporting in published clinical trials exists - this is one of the reasons that clinical trial databases now available were set up. The authors of this paper report an analysis of the outcomes reported in published papers describing unlicensed (off-label) uses of gabapentin, using internal company documents made available as a result of US litigation. The off-label uses studied were migraine prophylaxis, treatment of bipolar disorders, neuropathic pain, and nociceptive pain, and the analysis de...

Pharmacologic attenuation of pelvic pain in a Murine model of interstitial cystitis

Conclusions: These data demonstrate that bladder-associated pelvic pain is attenuated by antagonists of NK1R, H2R, and H1R. Therefore, NK1R, H2R and H1R represent direct therapeutic targets for pain in IC/PBS and potentially other chronic pain conditions. (Source: BMC Urology - Latest articles)

Published evidence for off-label gabapentin uses is incomplete

A comparison of the published evidence for off-label uses of gabapentin with reports available to the manufacturer found significant discrepancies in outcome reporting and unpublished negative trials. (Source: Multiple Sclerosis Trust)

Report shows Pfizer's hand in Neurontin studies

CHICAGO (Reuters) - A study of internal company documents suggests Pfizer Inc altered or omitted unfavorable study findings to expand its epilepsy drug Neurontin's market, U.S. researchers said on Wednesday, offering a look at how drugmakers influence scientific research. (Source: Reuters: Health)<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>

Gabapentin Studies for Off-Label Uses Cooked? (CME/CE, with audio)

Primary outcome measures were apparently a moving target in many company-sponsored studies of gabapentin (Neurontin) for off-label uses such as neuropathic pain and bipolar disorder, researchers have suggested. (Source: MedPage Today Public Health)

Outcome Reporting in Industry-Sponsored Trials of Gabapentin for Off-Label Use

This article compares outcomes specified in research protocols with those described in published reports for trials of off-label use of gabapentin that were sponsored by the manufacturer. The authors had access to internal company documents; the article details discrepancies between the published record and the research plans. (Source: New England Journal of Medicine)

GlaxoSmithKline and XenoPort announce extension of GSK1838262 (XP13512) FDA review date to 9 February, 2010

GlaxoSmithKline (NYSE: GSK) and XenoPort, Inc. (Nasdaq: XNPT) today announced that the U.S. Food and Drug Administration (FDA) has extended the original Prescription Drug User Fee Act (PDUFA) goal date for its review of the New Drug Application (NDA) for GSK1838262/XP13512 (gabapentin enacarbil) to February 9, 2010. (Source: GSK news)

Cutaneous piloleiomyomata.

Authors: Smith G, Heidary N, Patel R, Rosenman K, Meehan SA, Kamino H, Sanchez M A 49-year-old man presented with an eight-month history of intermittently painful, subcutaneous nodules that were increasing in size, number, and pain intensity. A biopsy specimen showed smooth muscle proliferation, which also stained positive for actin, and was consistent with piloleiomyoma. The patient was placed initially on gabapentin and then nifedipine with very limited success in pain control. The lesions continued to proliferate, and the patient was referred to surgery for excision. PMID: 19891918 [PubMed - in process] (Source: Dermatol Online J)

[Co-analgesics--today and tomorrow--a receptor-based overview of therapeutical options]

We describe the peripheral action sites of co-analgesics, such as cannabinoids, capsaicin, bisphosphonates, steroids and somatostatin. We also summarise the effect of peripherally and centrally acting ion-channel blockers, e.g. local anaesthetics, carbamazepine and tolperisone working on sodium channels and gabapentin and pregabalin working on calcium channels. Finally, central analgesic mechanisms are discussed, for instance the inhibition of NMDA-receptors by ketamine or magnesium, the stimulation of alpha2-receptors by clonidine, tizanidine or antidepressants, the activation of GABA-receptors through baclofen and other analgesic mechanisms of i.e. ondansetron and neostigmine. PMID: 19918705 [PubMed - in process] (Source: Anasthesiologie, Intensivmedizin, Notfallmedizin, Schmerzthera...<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>

Gabapentin: Delirium, dependence, and withdrawal delirium: case report

(Source: Reactions)

Fibromyalgia: From treatment to rehabilitation

Abstract: Fibromyalgia is a clinical syndrome of chronic widespread pain and reduced pain thresholds to palpation. The pathophysiology remains unknown, but there is increasing evidence that peripheral and central sensitization cause an amplification of sensory impulses that may alter pain perception in fibromyalgia patients. Interventions to treat fibromyalgia should aim at different targets simultaneously in order to reduce peripheral and central sensitization. There are both pharmacologic and non-pharmacologic approaches with evidence for effectiveness in the treatment of fibromyalgia and its associated symptoms. Evidence from randomized trials and meta-analyses shows that partial and short-term improvements in fibromyalgia symptoms can be achieved with low doses of antidepressants and w...

Antiepileptic drugs combined with high-frequency electrical stimulation in the ventral hippocampus modify pilocarpine-induced status epilepticus in rats

Discussion: Subeffective doses of antiepileptic drugs that increase the [gamma]-aminobutyric acid (GABA)ergic neurotransmission may represent a therapeutic tool to augment the HFS-induced anticonvulsant effects. (Source: Epilepsia)

Gabapentin: Myoclonus: 3 case reports

(Source: Reactions)

SUNCT Syndrome Successfully Treated with the Combination of Oxcarbazepine and Gabapentin

Short-lasting unilateral neuralgiform headache attacks with conjunctival injection and tearing (SUNCT) is a syndrome of intermittent, brief, unilateral, severe paroxysms of orbital-temporal pain recurring multiple times per day. The pain modulation is often very difficult. The reported SUNCT patient is the first who responded to a combination treatment of oxcarbazepine and gabapentin. (Source: Pain Medicine)<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>

A comparison of gabapentin and ketamine in acute and chronic pain after hysterectomy.

CONCLUSION: Gabapentin and ketamine are similar in improving early pain control and in decreasing opioid consumption; however, gabapentin also prevented chronic pain in the first 6 postoperative months. PMID: 19843803 [PubMed - in process] (Source: Anesthesia and Analgesia)

Combo pill an option for diabetes-related nerve pain

NEW YORK (Reuters Health) - A single pill containing the pain relievers tramadol and acetaminophen is as effective as the drug gabapentin for treating diabetes-related nerve pain, according to study findings presented Tuesday at the 20th World Diabetes Congress in Montreal. (Source: Reuters: Health)

Combo Pill an Option for Diabetes-Related Nerve Pain

A single pill containing the pain relievers tramadol and acetaminophen is as effective as the drug gabapentin for treating diabetes-related nerve pain, according to study findings presented Tuesday at the 20th World Diabetes Congress in Montreal. Source: Reuters Health Related MedlinePlus Topics: Diabetic Nerve Problems, Pain Relievers (Source: MedlinePlus Health News)

Management of Neuropathic Pain in Dialysis Patients: An Effective Approach with Gabapentin

In this study, we administered gabapentin, a novel antiepileptic drug which is excreted at 98% unaltered by the kidneys, to 7 hemodialysis patients (4 female, 3 male) from 65 to 75 years of age and at 65 to 70 kg of body weight who suffered from restless legs syndrome (4 patients), pruritus (1 patient), neuralgia (1 patient), and carpal tunnel syndrome (1 patient). Recommended dosing with adjustments for the degree of kidney failure provoked severe somnolence and dizziness affecting all patients. On an "observe and treat" basis, we determined the optimum dose was 50% lower than the suggested dose. Patients responded rapidly with significant improvement on the lower dose schedule. A follow-up period of 8 to 32 months confirmed the good outcome. We determine that administration of gabapentin...

GABA and valproate modulate trigeminovascular nociceptive transmission in the thalamus.

Authors: Andreou AP, Shields KG, Goadsby PJ Objective: To study the role of GABA receptors in thalamic relay neurons in the ventroposteromedial (VPM) nucleus of the rat activated by a trigeminovascular nociceptive stimulus in relationship to migraine, and the potential modulation of nociceptive transmission by GABA acting anti-convulsants. Methods: Trigeminovascular nociceptive afferents were identified in the VPM by electrical stimulation of the superior sagittal sinus (SSS), and cell bodies identified by activation with L-glutamate. The effect of GABA, valproate and gabapentin ejection during SSS stimulation and microiontophoresis of L-glutamate was studied. GABA responses were characterized with the selective GABA(A) and GABA(B) agonists muscimol and baclofen, respectively, and the ...<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>

Depomed Reports Results From Two Phase 3 Clinical Trials Evaluating Non-Hormonal Therapy For Menopausal Hot Flashes

Depomed, Inc. (NASDAQ:DEPO) announced top-line results from the BREEZE 1 and 2 Phase 3 clinical trials evaluating the safety and efficacy of SeradaTM, an investigational non-hormonal extended release formulation of gabapentin for the treatment of menopausal hot flashes. In the higher dose treatment arm of the two doses evaluated, the 1800mg dose achieved positive results at 4 weeks. (Source: Health News from Medical News Today)

Health News of the Day

is a daily summary made from the selected links I post on Twitter. It is in a bullet points format with links to the original sources which include 350 RSS feeds that produce about 2,500 items per day:Combined gabapentin and nortriptyline seems to be more efficacious than either drug given alone for neuropathic pain http://bit.ly/2yUgJz"The feminisation of Britain's medical workforce is underway. Are women safer doctors?" asks The Lancet http://bit.ly/3v594WHormone replacement possibly leads to the development of more aggressive lung cancers and decreases survival http://bit.ly/JYTN813 million preterm babies were born worldwide; 85% of these births (11 million births) occurred in Africa and Asia. Rate of preterm birth in U.S. has increased by 35% in the past 25 years, due to assisted repr...

Gabapentin Receptor őĪ2őī-1 Is a Neuronal Thrombospondin Receptor Responsible for Excitatory CNS Synaptogenesis

√?agla Eroglu, Nicola J. Allen, Michael W. Susman, Nancy A. O'Rourke, Chan Young Park, Engin √?zkan, Chandrani Chakraborty, Sara B. Mulinyawe, Douglas S. Annis, Andrew D. Huberman, Eric M. Green, Jack Lawler, Ricardo Dolmetsch, K. Christopher Garcia, Stephen J. Smith, Z. David Luo, Arnon Rosenthal, Deane F. Mosher, Ben A. Barres. Synapses are asymmetric cellular adhesions that are critical for nervous system development and function, but the mechanisms that induce their formation are not well understood. We have previously.... (Source: Cell)

[Articles] Nortriptyline and gabapentin, alone and in combination for neuropathic pain: a double-blind, randomised controlled crossover trial

Drugs for neuropathic pain have incomplete efficacy and dose-limiting side-effects when given as monotherapy. We assessed the efficacy and tolerability of combined nortriptyline and gabapentin compared with each drug given alone. (Source: LANCET)

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