METACAM (Meloxicam) Injection, Solution [Boehringer Ingelheim Vetmedica, Inc.]

Updated Date: Feb 18, 2014 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

Validation of assay indicating method development of meloxicam in bulk and some of its tablet dosage forms by RP-HPLC

A novel, simple and economic reverse phase high performance liquid chromatography (RP-HPLC) method has been developed for the quantification of Meloxicam in bulk and tablet dosage form with greater precision and accuracy. Separation was achieved on Develosil ODS HG-5 RP C18, (15cm x 4.6 mm i.d. 5mum) column in isocratic mode with mobile phase consisting of acetonitrile :phosphate buffer(pH 3.4) (60:40) with a flow rate of 1 mL/min. The detection was carried out at 268 nm. The retention time of Meloxicam was found to be 2.09 min.The method was validated as per ICH guidelines. Linearity was established for Meloxicam in the range 20 - 120 mug / ml with R2 value 0.996. The percentage recovery of Meloxicam was found to be in the range 99.99-100.46%. The high recovery and low relative standard d...

Ellagic acid protects against carrageenan-induced acute inflammation through inhibition of nuclear factor kappa B, inducible cyclooxygenase and proinflammatory cytokines and enhancement of interleukin-10 via an antioxidant mechanism.

In this study, the protective role of ellagic acid against carrageenan-induced acute inflammation was assessed. In addition, the immunomodulatory action, the antioxidant effects, and the role of COX-2 and NF-κB were also investigated. Inflammation was induced by the injection of 100μl of 1.5% carrageenan solution. Ellagic acid (10, 25, 50, 100 and 200mg/kg), indomethacin (10mg/kg), meloxicam (4mg/kg), and saline, were injected 2h before carrageenan injection. The percentage inhibition in the paw weight was calculated. Paws, MDA, NO, GSH, IL-1β, TNF-α, IL-10 and NF-κB mRNA expression were estimated. Formalin fixed hind paws were used for histopathological examination and immunohistochemical staining for COX-2 expression. Ellagic acid, meloxicam and indomethacin reduced paws, edema, MDA...

MELOXICAM Tablet [International Labs, Inc.]

Updated Date: Feb 11, 2014 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

Synthesis and Characterization of the Magnetic Molecularly Imprinted Polymer Nanoparticles Using N, N-bis Methacryloyl Ethylenediamine as a New Cross-linking Agent for Controlled Release of Meloxicam.

Authors: Azodi-Deilami S, Abdouss M, Kordestani D Abstract The novel magnetic molecularly imprinted polymers (MMIPs) had been synthesized using N,N-bis methacryloyl ethylenediamine as a cross-linker for the controlled release of meloxicam at a pH of 1.0 (simulated gastric fluid), at a pH of 6.8 (simulated intestinal fluid) and at a pH of 7.4 (simulated biological fluids). The MMIPs were prepared via precipitation polymerization, using Fe3O4 as a magnetic component, meloxicam as a template molecule, methacrylic acid (MAA) as a functional monomer and N,N-bis methacryloyl ethylenediamine as a new cross-linker in acetonitrile/dimethyl sulfoxide porogen. Magnetic non-molecularly imprinted polymers (MNIPs) were also prepared with the same synthesis procedure as with MMIPs only without th...<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>

Detection of Clinically Relevant Pain Relief in Cats with Degenerative Joint Disease Associated Pain

Conclusions and Clinical ImportanceUsing both a client?specific and a general clinical metrology instrument, owners of cats with DJD were able to detect evident recurrence of clinical signs after withdrawal of active medication than after withdrawal of placebo, and that this study design might be a novel and useful way to circumvent the placebo effect and detect the efficacy of pain?relieving medications. (Source: Journal of Veterinary Internal Medicine)

MELOXICAM Tablet [International Labs, Inc.]

Updated Date: Feb 5, 2014 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

Retraction Note: Meloxicam Taste-Masked Oral Disintegrating Tablet with Dissolution Enhanced by Ion Exchange Resins and Cyclodextrin.

Authors: Samprasit W, Akkaramongkolporn P, Ngawhirunpat T, Rojanarata T, Opanasopit P PMID: 24493384 [PubMed - as supplied by publisher] (Source: AAPS PharmSciTech)

Comparison of the effects of dexketoprofen trometamol, meloxicam and diclofenac sodium on fibular fracture healing, kidney and liver: An experimental rat model

Conclusion: Based on our results, DIC can be considered a relatively safe medication in patients with fractures. (Source: Injury)

Pharmacokinetics of meloxicam administered orally to rabbits (Oryctolagus cuniculus) for 29 days.

Conclusions and Clinical Relevance-Plasma concentrations of meloxicam for rabbits in the present study were similar to those previously reported in rabbits that received 1. 0 mg of meloxicam/kg, PO every 24 hours, for 5 days. Results suggested that a dosage of 1. 0 mg/kg, PO, every 24 hours for up to 29 days may be safe for use in healthy rabbits. PMID: 24471756 [PubMed - in process] (Source: American Journal of Veterinary Research)<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>

Meloxicam pharmacokinetics using nonlinear mixed?effects modeling in ferrets after single subcutaneous administration

An allopurinol?controlled, multicenter, randomized, double?blind, parallel between?group, comparative study of febuxostat in Chinese patients with gout and hyperuricemia

ConclusionsThe UL efficacy of daily febuxostat 80 mg was greater than that of febuxostat 40 mg and allopurinol 300 mg, which exhibited comparable UL efficacy. Safety of febuxostat and allopurinol was comparable at the doses tested. (Source: APLAR Journal of Rheumatology)

Effectiveness of Chloroquine and Inflammatory Cytokine Response in Patients With Early Persistent Musculoskeletal Pain and Arthritis Following Chikungunya Virus Infection

ConclusionThis exploratory community intervention trial failed to identify an advantage of CQ over meloxicam to treat early musculoskeletal pain and arthritis following acute CHIK virus infection, but therapeutic efficacy of CQ was not ruled out. The inflammatory cytokine response was intense and was not consistent with clinical status. (Source: Arthritis and Rheumatism)

MELOXICAM Tablet [Lupin Pharmaceuticals, Inc.]

Updated Date: Jan 27, 2014 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

MELOXICAM Tablet [Carlsbad Technology, Inc.]

Updated Date: Jan 22, 2014 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>

Participation of Prostaglandin in the Salivary Secretion of Hyperthyroid Rats

Conclusion: COX-2 inhibition and, consequently, the synthesis of PGs by the injection of MLX, a non-steroidal anti-inflammatory drug, did not modulate the salivary secretion of HYPER rats. (Source: Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontics)

Effect of mechanical properties on the release of meloxicam from poloxamer gel bases

O Inal, E Algin YaparIndian Journal of Pharmaceutical Sciences 2013 75(6):700-706Thermoreversible gel of meloxicam, efficient for the treatment of joint diseases, was aimed to prepare for night application available for chronotherapy in this study. Poloxamer 407 and 188 polymers were used at 20-30&#x0025; w/w as a vehicle in combination with different additives (polyvinylmethylether maleic anhydride copolymer, hydroxypropyl methylcellulose, polyethylene glycol 400, dimethyl sulfoxide, sodium chloride). Characterisation of prepared gels was evaluated by viscosity and texture analysis, and the effect of formulation variables on the gel formulations were evaluated by in vitro drug release and erosion studies. Between the investigated gel bases, Poloxamer 407-hydroxypropyl methylcellulose gel ...

MELOXICAM Tablet [New Horizon Rx Group, LLC]

Updated Date: Dec 31, 2013 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

Green Sweat: An Atypical Finding in Drug?Induced Liver Disease

This article is protected by copyright. All rights reserved. (Source: Liver International)

Current attitudes regarding the use of perioperative analgesics in dogs and cats by Brazilian veterinarians

ConclusionsAlthough the number of Brazilian veterinarians believed that their knowledge in the area was lower than in other countries, the focus in pain management was similar or higher than in other countries, showing a good attitude in pain relief in animals. (Source: Veterinary Anaesthesia and Analgesia)<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>

In vitro hepatic microsomal metabolism of meloxicam in koalas (Phascolarctos cinereus), brushtail possums (Trichosurus vulpecula), ringtail possums (Pseudocheirus peregrinus), rats (Rattus norvegicus) and dogs (Canis lupus familiaris).

This study indicates that eutherians such as rats or dogs serve as inadequate models for dosage extrapolation of this drug to marsupials due to differences in hepatic turnover rate. Furthermore, as in vivo Cl is one of the pharmacokinetic indexes for determining therapeutic drug dosages, this study demonstrates the utility of in vitro to in vivo scaling as an alternative prediction method of drug Cl in koalas. PMID: 24345479 [PubMed - as supplied by publisher] (Source: Comparative biochemistry and physiology. Toxicology and pharmacology : CBP)

Effects of Diabetes on the Eye [Special Issue]

Hyperglycemia has toxic effects on almost all cells in the body. Ophthalmic complications of hyperglycemia are most profound in cornea and retina. Seventy percent of diabetics suffer from corneal complications, collectively called diabetic keratopathy, which includes include recurrent erosions, delayed wound healing, ulcers, and edema. Confocal microscopy has permitted in vivo imaging of corneal nerves, which are also affected in diabetic subjects. Gene therapies upregulating MNNG HOS transforming gene (cMet) and/or downregulating MMP10 and cathepsin S are potential future therapies for diabetic keratopathy. Diabetic retinopathy (DR) is the most common cause of blindness in people over the age of 50. There is accumulating evidence that DR is an inflammatory disease. The initial events in a...

Prostacyclin mediates neuropathic pain through interleukin 1β-expressing resident macrophages

Summary: Prostacyclin synthesized at the sites of nerve injuries regulates the accumulation of resident macrophages. These cells express IL1β, which supports the development of neuropathic pain.Abstract: Prostacyclin is an important mediator of peripheral pain sensation. Here, we investigated its potential participation in mediating neuropathic pain and found that prostacyclin receptor (IP) knockout mice exhibited markedly decreased pain behavior. Application of an IP antagonist to the injury site or selective IP deficiency in myeloid cells mimicked the antinociceptive effect observed in IP knockout mice. At the site of nerve injury, IP was expressed in interleukin (IL) 1β-containing resident macrophages, which were less common in IP knockout mice. Local administration of the IP agonist ...

The Effect of Combined Therapy with Tamsulosin Hydrochloride and Meloxicam in Patients with Benign Prostatic Hyperplasia Symptoms and Impact on Nocturia and Sleep Quality

Conclusions Cyclooxygenase (COX)-2 inhibitors in combination with an alpha blocker may decrease benign prostatic hyperplasia symptoms and increase sleep quality without serious side effects. (Source: International Braz J Urol)

Nonsteroidal anti-inflammatory therapy: changes on renal function of healthy dogs.

CONCLUSIONS: Meloxicam and etodolac were the drugs that have proven to be safer for short-term therapy in healthy dogs in relation to renal function. NSAIDs ketoprofen and nimesulide should be used judiciously in dogs with renal dysfunction, since there are promoted changes in renal function. PMID: 24316857 [PubMed - in process] (Source: Acta Cirurgica Brasileira)<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>

Agonist of the adenosine A3 receptor, IB-MECA, and inhibitor of cyclooxygenase-2, meloxicam, given alone or in a combination early after total body irradiation enhance survival of γ-irradiated mice.

Authors: Hofer M, Pospíšil M, Dušek L, Hoferová Z, Komůrková D Abstract There exists a requirement for drugs which would be useful in therapy of an acute radiation damage of a mammalian organism. The aim of the study was to evaluate survival parameters in mice exposed to a lethal γ-ray dose of 8.5 Gy and treated with single doses of an adenosine A3 receptor agonist, IB-MECA, or a cyclooxygenase-2 (COX-2) inhibitor, meloxicam, administered alone or in a combination early after irradiation, i.e., 0.5 and 1 h post-irradiation, respectively. The assessed parameters were the mean survival time (MST) and the cumulative percentage 30-day survival (CPS). Administrations of single intraperitoneal doses of either IB-MECA 0.5 h post-irradiation or meloxicam 1 h post-irradiation res...

A Handy Clue: Palmar Fasciitis and Polyarthritis Syndrome

Rheumatologic symptoms signaled a deadly underlying disorder. A 48-year-old woman presented with progressive pain and functional impairment of both hands. She was in her usual state of good health until 3 months prior to admission, when she developed pain and stiffness associated with swelling of the proximal and distal interphalangeal joints. Her joint symptoms were more pronounced in the morning, improving over the course of the day. Yet, difficulty flexing and extending all fingers continued, significantly compromising her ability to carry out routine daily activities. Meloxicam was prescribed but offered little relief. Treatment with hydroxychloroquine and a brief prednisone taper followed, and while this transiently helped resolve some of the articular swelling, stiffness, and pain, ...

Comparative study of novel ultradeformable liposomes: menthosomes, transfersomes and liposomes for enhancing skin permeation of meloxicam.

Authors: Duangjit S, Obata Y, Sano H, Onuki Y, Opanasopit P, Ngawhirunpat T, Miyoshi T, Kato S, Takayama K Abstract In the present study, novel ultradeformable liposomes (menthosomes; MTS), deformable liposomes (transfersomes; TFS) and conventional liposomes (CLP) were compared in their potential for transdermal delivery of meloxicam (MX). MTS, TFS and CLP were investigated for size, size distribution, zeta potential, elasticity, entrapment efficiency and stability. In vitro skin permeation using hairless mice skin was evaluated. Vesicular morphology was observed under freeze-fractured transmission electron microscopy (FF-TEM). Intrinsic thermal properties were performed using differential scanning calorimetry (DSC) and X-ray diffraction. The skin permeation mechanism was character...

Higher Frequency of Peripheral Blood Interleukin 21 Positive Follicular Helper T Cells in Patients with Ankylosing Spondylitis.

CONCLUSION: These data suggest that IL-21+CXCR5+CD4+ T cells may be associated with development of AS and that the frequency of IL-21+CXCR5+CD4+ T cells may be a biomarker for evaluation of disease activity and drug responses in patients with AS, particularly in drug-responding patients. PMID: 24187103 [PubMed - as supplied by publisher] (Source: J Rheumatol)

Intra-articular injection of the selective cyclooxygenase-2 inhibitor meloxicam (Mobic) reduces experimental osteoarthritis and nociception in rats

Conclusions: Intra-articular injection of meloxicam (1) attenuates the development of OA, (2) concomitantly reduces nociception, and (3) modulates chondrocyte metabolism, possibly through inhibition of cellular p38 and JNK, but enhances ERK expression. (Source: Osteoarthritis and Cartilage)<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>

Chloroquine effectiveness and inflammatory cytokine response in early persistent post chikungunya musculoskeletal pain and arthritis

Conclusion: This exploratory community intervention trial failed to identify an advantage of chloroquine over meloxicam to treat early musculoskeletal pain and arthritis following acute CHIKV but does not rule out a therapeutic efficacy of chloroquine. Inflammatory cytokine response was intense and not consistent with clinical status.(Trial Registered: Clinical Trial Registry India /2010/091/000208) © 2013 American College of Rheumatology. (Source: Arthritis and Rheumatism)

meloxicam, Mobic

Title: meloxicam, MobicCategory: MedicationsCreated: 11/8/2000 8:38:00 PMLast Editorial Review: 10/11/2013 12:00:00 AM (Source: MedicineNet Medications General)

Tolerance to COX-2 inhibitors in children with hypersensitivity to non-steroidal anti-inflammatory drugs.

CONCLUSIONS: These data indicate that both etoricoxib and meloxicam are good alternatives for treatment in older children with hypersensitivity to NSAIDs. This article is protected by copyright. All rights reserved. PMID: 24116718 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)

Effects of carprofen and meloxicam on C-reactive protein, ceruloplasmin, and fibrinogen concentrations in dogs undergoing ovariohysterectomy.

Conclusions and Clinical Relevance-Perioperative administration of both carprofen and meloxicam did not significantly affect the concentrations of CRP, ceruloplasmin, and fibrinogen in dogs undergoing OVH. Thus, use of carprofen or meloxicam should not affect clinical interpretation of results for these 3 acute-phase proteins. PMID: 24066910 [PubMed - in process] (Source: American Journal of Veterinary Research)<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>

The COX-2 inhibitor meloxicam prevents pregnancy when administered as an emergency contraceptive to nonhuman primates

Conclusions: Oral COX-2 inhibitor administration can prevent pregnancy after a single instance of breeding in primates. While meloxicam may be ineffective for regular contraception, pharmacological inhibition of COX-2 may be an effective method of emergency contraception for women.Implications: COX-2 inhibitors can interfere with ovulation, but the contraceptive efficacy of drugs of this class has not been directly tested. This study, conducted in nonhuman primates, is the first to suggest that a COX-2 inhibitor may be effective as an emergency contraceptive. (Source: Contraception)

Image-guided Diagnostic Injections With Anesthetic Versus Magnetic Resonance Arthrograms for the Diagnosis of Suspected Hip Pain

M.T. is a 38-year-old woman with a 6-month history of atraumatic right buttock, groin, and lateral hip pain. She initially presented to her primary care physician who obtained plain films of her hip and low back, which were read as normal. She was given a prescription for meloxicam 15 mg daily and was sent to physical therapy. After 6 weeks of appropriate therapy, she continued with a 6/10 pain that limited her ability to play golf and to exercise. She was referred to you for further diagnosis and treatment. (Source: PM and R)

In vitro effects of meloxicam on metabolism in articular chondrocytes from dogs with naturally occurring osteoarthritis.

Conclusions and Clinical Relevance-Results suggested that in vitro meloxicam treatment of osteoarthritic canine cartilage for up to 30 days did not induce matrix degradation or stimulate MMP production. Meloxicam lowered PGE2 release from this tissue, and effects on tissue chondrocyte content and matrix composition were neutral. PMID: 23977892 [PubMed - in process] (Source: American Journal of Veterinary Research)

Intra-articular anaesthesia mitigates established pain in experimental osteoarthritis: a preliminary study of gait impulse redistribution as a biomarker of analgesia pharmacodynamics

Conclusion: Joint function and the role of persistent joint pain in the development of osteoarthritis can be investigated effectively and efficiently in a large animal model through the use of Impulse Ratio. Impulse Ratio can be a functionally relevant and sensitive biomarker of locomotion-related joint pain. (Source: Osteoarthritis and Cartilage)

Preparation and evaluation of solid lipid nanoparticles based nanogel for dermal delivery of meloxicam.

Authors: Khurana S, Bedi PM, Jain NK Abstract The aim of the current investigation was to prepare and investigate the potential of solid lipid nanoparticles based gel (SLN-gel) for the dermal delivery of meloxicam (MLX). The meloxicam loaded SLN (MLX-SLN) gel was developed and characterized by means of photon correlation spectroscopy, rheometry, and differential scanning calorimetry to determine the physicochemical properties. The behavior of SLN gel on rat skin was evaluated in vitro using Franz diffusion cells to determine the skin permeation and penetration characteristics, in vivo on mice to determine the skin tolerance by histopathological examinations. The anti-inflammatory potential of SLN gel was assessed by carrageenan induced rat paw edema test. Biophysical studies includ...

A Modified Viborg's Triangle Approach for Surgical Drainage of Guttural Pouches Empyema Through Placement of a Fenestrated Tube in a Mare

Abstract: A 7-year-old mare was brought to the clinic with a history of falling 1 month earlier and bilateral mucosanguinous nasal discharge, respiratory distress, and bilateral swelling caudal to the posterior margin of vertical rami of mandibles for 3 weeks. Lateral radiography of the neck region revealed gas-filled soft tissue density caudal to the mandibles. Empyema of the guttural pouches was diagnosed and surgical drainage was planned by placement of a fenestrated tube. A skin incision was made at the dependent part of the swelling in Viborg's triangle on both sides; guttural pouches were exposed and mucosanguinous contents drained by lancing the pouches. Fenestrated tubes, prepared from the tubing of a urine collection bag, were fixed into the guttural pouches by anchoring to the wa...

New-Onset Gastrointestinal Polyposis

Question: A 60-year-old man presented to the outpatient gastroenterology clinic with a 9-month history of diarrhea. The diarrhea started gradually, intermittent in course; he reported anywhere between 2 to 10 loose bowel movements a day, with a lot of mucous in the stool but no blood. This was associated with upper abdominal discomfort, bloating, early satiety, and nausea. He complained of significant fatigue and lost about 40 lbs during this period of illness. He complained of his fingernails and toenails becoming very brittle and eventually lost all of them, burning of the tongue, decreased taste sensation, hair loss, decreased libido, and development of skin hyperpigmentation over his thighs. The patient??s medical history is remarkable for hypertension, hyperlipidemia, osteoarthritis,...

Assessment of postoperative pain after unilateral mastectomy using two different surgical techniques in dogs

Conclusions: The two surgical techniques produced similar surgical times, incidence of perioperative complications and postoperative pain. Multimodal analgesia is recommended for treatment of postoperative pain in dogs undergoing unilateral mastectomy. (Source: Acta Veterinaria Scandinavica)

Effects of meloxicam, a semi-selective cyclo-oxygenase 2 (COX-2) inhibitor, on the ultrasound appearance of the dominant follicle before and after the luteinizing hormone (LH) surge

The objective of this study was to assess the effect of meloxicam on ovulatory function using ultrasound. (Source: Contraception)<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>

Comparison of premedication with buprenorphine or methadone with meloxicam for postoperative analgesia in dogs undergoing orthopaedic surgery

ObjectivesTo determine whether methadone, administered before orthopaedic surgery, results in improved postoperative analgesia compared to buprenorphine. MethodsThirty?eight dogs undergoing orthopaedic surgeries (the majority being tibial tuberosity advancement or elbow arthrotomy) were premedicated with 0??·??03??mg/kg acepromazine and either 20??µg/kg buprenorphine or 0??·??5??mg/kg methadone, intramuscularly, allocated randomly. Anaesthesia was induced with propofol intravenously to effect and maintained with isoflurane in oxygen. 0??·??2??mg/kg meloxicam was administered at anaesthetic induction. Sedation was assessed by means of a dynamic interactive visual analogue and simple descriptive scales and pain by dynamic interactive visual analogue and the short form Glasgow...

Comparison of postoperative effects between lidocaine infusion, meloxicam, and their combination in dogs undergoing ovariohysterectomy

Conclusions and Clinical relevanceThis study suggests that, with the scoring system used, IV lidocaine and meloxicam provide similar and adequate post?operative analgesia in healthy dogs undergoing ovariohysterectomy. (Source: Veterinary Anaesthesia and Analgesia)

Meloxicam Taste-Masked Oral Disintegrating Tablet with Dissolution Enhanced by Ion Exchange Resins and Cyclodextrin.

Authors: Samprasit W, Akkaramongkolporn P, Ngawhirunpat T, Rojanarata T, Opanasopit P Abstract The purpose of this study was to develop taste-masked oral disintegrating tablets (ODTs) using the combination of ion exchange resin and cyclodextrin, to mask the bitter taste and enhance drug dissolution. Meloxicam (MX) was selected as a model drug with poor water solubility and a bitter taste. Formulations containing various forms of MX (free drug, MX-loaded resin or resinate, complexes of MX and 2-hydroxypropyl-β-cyclodextrin (HPβCD) or MX/HPβCD complexes, and a mixture of resinate and MX/HPβCD complexes) were made and tablets were prepared by direct compression. The ODTs were evaluated for weight variation, thickness, diameter, hardness, friability, disintegration time, wetting ti...

Unfolded protein response to global ischemia following 48 h of reperfusion in the rat brain: the effect of age and meloxicam

In this study, we conclude that the unfolded protein response (UPR) to ischemic/reperfusion insult is age? and probably inflammation?dependent and could play an important role in ischemic vulnerability. The UPR strongly decreased in aged rats, suggesting a reduced ability for cell survival. The increase in the mRNA levels of UPR gene transcripts in 3?month?old animals was abolished or even reverted by treatment with meloxicam, an anti?inflammatory agent. (Source: Journal of Neurochemistry)

Meloxicam Treatment in Cockatiels (Nymphicus hollandicus) Infected With Avian Bornavirus

This study was designed to investigate the effectiveness of meloxicam in the treatment of proventricular dilatation disease induced by challenge with avian bornavirus (ABV), strain M24. Three groups of 4 cockatiels were employed. Group 1 was challenged with ABV alone, group 2 was challenged with ABV and 20 days later began daily oral meloxicam treatment, and group 3 received daily oral meloxicam alone. All birds in groups 1 and 3 remained in apparent good health and maintained their weight until being euthanized on day 150 after challenge (group 1) or day 130 of treatment (group 3). In contrast, group 2 birds died or were euthanized on or before day 98 because of severe weight loss and depression. Necropsy and histopathology results indicated that all birds in group 2 had pathologic eviden...<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>

Systematic Review of Nonsteroidal Anti?Inflammatory Drug?Induced Adverse Effects in Dogs

Unfolded protein response to global ischemia following 48 hours of reperfusion in the rat brain: The effect of age and meloxicam

This article is protected by copyright. All rights reserved. (Source: Journal of Neurochemistry)

Collagenous Sprue, an Enigma in the Spectrum of Celiac Disease

A 64-year-old white woman presented to our clinic with bilateral swelling of her hands and feet and an unintentional 50-pound weight loss over the past year. She was having 1 to 2 bowel movements daily with occasional additional watery stools without dietary variation. Laboratory values were as follows: alanine aminotransferase, 35 IU/L; aspartate aminotransferase, 46 IU/L; alkaline phosphatase, 117 IU/L; total bilirubin, 0.3 mg/dL; albumin, 1.7 g/dL; and hemoglobin, 11.6 g/dL. Her liver function tests later normalized after discontinuing her statin and meloxicam, but given her weight loss she was evaluated endoscopically. Esophagogastroduodenoscopy showed moderately erythematous mucosa of the entire stomach and blunted duodenal mucosa ( A). Her colonoscopy was normal. A biopsy showed al...

Amelioration of cisplatin-induced mouse renal lesions by a cyclooxygenase (COX)-2 selective inhibitor.

In this study, we investigated the effects of the cyclooxygenase (COX)-2 selective inhibitor, meloxicam, on cisplatin-induced inflammation, oxidative stress and renal lesions in BALB/c mice. A single cisplatin injection (13mg/kg, i.p.) significantly increased plasma creatinine, blood urea nitrogen and urinary glucose accompanied by a concomitant increase in COX-2 mRNA and COX-2 protein levels. These changes in renal lesion parameters were diminished by simultaneous treatment of meloxicam (0.7mg/kg/day in drinking water). The expression of oxidative stress markers, p47(phox), p67(phox), hemoxygenase-1 (HO-1), nicotinamide adenine dinucleotide phosphate (NADPH) oxidase 2 (NOX2) and 4-hydroxy-2-nonenal (4-HNE)-modified protein were increased with cisplatin injection. Simultaneous treatment of...

Effect of Meloxicam on Pregnancy Rate of Recipient Heifers Following Transfer of In Vitro Produced Embryos

Contents The main objective of this study was to determine if administration of meloxicam, a cyclooxygenase (COX) two inhibitor, to heifers in which embryo transfer (ET) is more difficult and requires a greater manipulation of the tract, would be beneficial. Nulliparous recipient heifers were divided in two groups: CON (n = 102), in which animals received 10 ml of saline IM (the same volume of meloxicam) and MEL (n = 105) animals that were treated with meloxicam. According to the degree in passing the catheter, recipients from both groups were classified as Grade I, easy (&lt; 60 s), and Grade II (more than 80 s), difficult. Immediately after embryo transfer, MEL recipients received an injection of 200 mg of meloxicam (10 ml).There was no difference in the pregnancy rates on Day ...<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>

Ulipristal acetate prevents ovulation more effectively than levonorgestrel: analysis of pooled data from three randomized trials of emergency contraception regimens

Conclusion: Although no EC treatment is 100% effective in inhibiting follicular rupture when administered in the late follicular phase, UPA is the most effective treatment, delaying ovulation for at least 5 days in 59% of the cycles. LNG is not different from placebo in inhibiting follicular rupture at this advanced phase of the cycle. No treatment was effective in postponing rupture when administered on the day of LH peak. (Source: Contraception)

Effects of buprenorphine and meloxicam analgesia on induced cerebral ischemia in C57BL/6 male mice.

Authors: Jacobsen KR, Fauerby N, Raida Z, Kalliokoski O, Hau J, Johansen FF, Abelson KS Abstract Laboratory mice constitute an extensively used model to study the pathologic and functional outcomes of cerebral ischemic stroke. The middle cerebral artery occlusion (MCAO) model requires surgical intervention, which potentially can result in postsurgical pain and stress. In the present study, we investigated whether buprenorphine and meloxicam, at clinically relevant doses provided pain relief without altering infarct volume in male C57BL/6 mice. Common known side-effects of buprenorphine, including decreased food consumption, were noted after surgery in buprenorphine-treated mice, but these effects were brief and seen only during the treatment period. Fecal corticosterone metabolites...

Synthesis of New N?Substituted 5?Arylidene?2,4?thiazolidinediones as Anti?Inflammatory and Antimicrobial Agents

Abstract A novel series of 5?arylidene?2,4?thiazolidinediones (TZDs) 2a??p was synthesized from the condensation of 3?((2?phenylthiazol?4?yl)methyl)thiazolidine?2,4?dione with different benzaldehyde derivatives. All the structures were confirmed by their spectral (IR, 1H NMR, 13C NMR and mass) and elemental analytical data. The new molecules were evaluated in vivo as anti?inflammatory agents in an acute experimental inflammation, evaluating the acute phase bone marrow response and phagocyte activity. All compounds, excepting one, reduced the absolute leukocytes count due to the lower neutrophil percentage. Phagocytary index was decreased by the same molecules, while only half of them reduced the phagocytary activity. The effect was superior to meloxicam, the reference ...

Robenacoxib versus meloxicam for the management of pain and inflammation associated with soft tissue surgery in dogs: a randomized, non-inferiority clinical trial

A treatment regimen of a new NSAID, robenacoxib, by subcutaneous injection followed by oral tablets, demonstrates good tolerability and non inferior efficacy compared to meloxicam for the management of perioperative pain and inflammation associated with soft tissue surgery in dogs. (Source: BMC Veterinary Research - Latest articles)

Pharmacokinetics of intravenously and orally administered meloxicam in sheep.

Conclusions and Clinical Relevance-Meloxicam administered PO at 1.0 mg/kg has good bioavailability with slow elimination kinetics in sheep. These data suggested that meloxicam may be clinically useful, provided the safety and analgesic efficacy of meloxicam as well as feed-related influences on its pharmacokinetics are established in ruminants. PMID: 23627392 [PubMed - in process] (Source: American Journal of Veterinary Research)<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>

Meloxicam in the treatment of in vitro and in vivo models of urinary bladder cancer.

Authors: Arantes-Rodrigues R, Pinto-Leite R, Ferreira R, Neuparth MJ, Pires MJ, Gaivão I, Palmeira C, Santos L, Colaço A, Oliveira P Abstract To assess the efficacy of meloxicam, a non-steroidal anti-inflammatory drug (NSAID), on three human urinary bladder-cancer cell lines (HT1376, T24 and 5637) and on mice urinary bladder cancer chemically induced by N-butyl-N-(4-hydroxybutyl) nitrosamine (BBN). The in vitro effects of meloxicam were assessed by optical microscopy, 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl tetrazolium bromide (MTT) method, flow cytometry and comet assay. In vivo, Hsd:ICR male mice were exposed to BBN in drinking water, over the course of 12 weeks. Subsequently, animals were treated with meloxicam by intraperitoneal route, for 6 consecutively weeks. Tumour deve...

Age and meloxicam modify the response of the glutamate vesicular transporters (VGLUTs) after transient global cerebral ischemia in the rat brain.

CONCLUSIONS: VGLUT1 and VGLUT3 presented an age-dependent response to ischemic damage, while this VGLUT response was age both and structure-dependent. In addition, COX-2 inhibition resulted in an increase of VGLUT1 and VGLUT2 protein amounts both in sham and injured animals together with a lessening of the transporters' response to ischemia. PMID: 23458738 [PubMed - in process] (Source: Brain Research Bulletin)

Myocardial infarction and individual nonsteroidal anti?inflammatory drugs meta?analysis of observational studies

ConclusionsMost frequently NSAIDs used in clinical practice, except naproxen, are associated with an increased risk of AMI at high doses or in persons with diagnosed coronary heart disease. For diclofenac and rofecoxib, the risk was increased at low and high doses. Copyright © 2013 John Wiley & Sons, Ltd. (Source: Pharmacoepidemiology and Drug Safety)

A novel approach to treatment of lymphangiosarcoma in a boxer dog

A five?year?old female boxer presented with a swelling in the area of the caudal mammary gland. The mass was surgically excised and histopathological examination revealed a poorly demarcated lesion, extending into mammary tissue and infiltrating the sinuses of adjacent lymph nodes. The diagnosis was lymphangiosarcoma. Full blood work, thoracic radiographs, abdominal and scar ultrasound were unremarkable, apart from possible inflammatory reactions in the latter and reactive/metastatic changes in inguinal lymph nodes. Doxorubicin treatment resulted in a 6?month recurrence free interval. At relapse, the dog was treated with metronomic chemotherapy using chlorambucil and meloxicam, which failed to adequately control the disease. Toceranib phosphate was introduced and resulted in almost c...

Feline Musculoskeletal Pain Index: Responsiveness and Testing of Criterion Validity

Conclusions and Clinical ImportanceNeither responsiveness nor criterion validity were detected by the inclusion criteria for cases in this study. The data suggest that further work is indicated to understand factors affecting activity in cats to optimize inclusion criteria. (Source: Journal of Veterinary Internal Medicine)<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>

Evaluation of glomerular filtration rate in cats with reduced renal mass and administered meloxicam and acetylsalicylic acid.

CONCLUSIONS AND CLINICAL RELEVANCE: Neither meloxicam nor acetylsalicylic acid had a measurable effect on urinary clearance of exogenously administered creatinine, serum creatinine concentration, or UP:C. These results are consistent with the hypothesis that GFR of euvolemic cats with normal or reduced renal function is not dependent on cyclooxygenase function. PMID: 23531076 [PubMed - in process] (Source: American Journal of Veterinary Research)

Pharmacokinetics of meloxicam in rabbits after oral administration of single and multiple doses.

CONCLUSIONS AND CLINICAL RELEVANCE: Plasma concentrations of meloxicam for rabbits in the present study were proportionally higher than those previously reported for rabbits receiving 0.2 mg of meloxicam/kg and were similar to those determined for animals of other species that received clinically effective doses. A dose of 1 mg/kg may be necessary to achieve clinically effective circulating concentrations of meloxicam in rabbits, although further studies are needed. PMID: 23531074 [PubMed - in process] (Source: American Journal of Veterinary Research)

Multicenter randomized prospective clinical evaluation of meloxicam administered via transmucosal oral spray in client?owned dogs

The clinical safety and efficacy of a transmucosal oral spray (TMOS) formulation of meloxicam was evaluated for the control of pain and inflammation associated with osteoarthritis in dogs. A total of 280 client?owned dogs were enrolled at fourteen veterinary clinics: there were 187 dogs in the meloxicam TMOS group and 93 in the placebo control group. Dogs received placebo or treatment spray once daily for twenty?eight days. Improvement in signs of osteoarthritis was measured using client?specific outcome measures (CSOM) made at days 14 and 28 and veterinary assessments of lameness and pain on palpation made at day 28. A significantly higher number of dogs in the meloxicam TMOS group were treatment successes at 28 days (72.6%) compared with the placebo group (46.9%), based on CSOM sc...

In vitro and in vivo characterization of meloxicam nanoparticles designed for nasal administration.

Authors: Kürti L, Gáspár R, Márki A, Kápolna E, Bocsik A, Veszelka S, Bartos C, Ambrus R, Vastag M, Deli MA, Szabó-Révész P Abstract The nasal pathway represents a non-invasive route for delivery of drugs to the systemic circulation. Nanonization of poorly soluble drugs offers a possibility to increase dissolution properties, epithelial permeability or even bioavailability. The aim of the present study was to use in vitro methods to screen formulations which were intended for nasal application, and to perform animal experiments for recognizing the differences in plasmakinetics of intranasal- and oral-administered meloxicam nanoparticles. Due to nanonization the solubility of meloxicam elevated up to 1.2mg/mL, additionally the extent of dissolution also increased, complete d...

Safety and efficacy of long-term esomeprazole 20¿mg in Japanese patients with a history of peptic ulcer receiving daily non-steroidal anti-inflammatory drugs

Conclusion: Long-term treatment with esomeprazole (20??mg once daily) is well tolerated and efficacious for preventing ulcer recurrence in Japanese NSAID users with a history of peptic ulcer.Trial registrationClinicalTrials.gov identifier NCT00595517. (Source: BMC Gastroenterology)<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>

Solid-State Characterization and Dissolution Properties of Meloxicam-Moringa Coagulant-PVP Ternary Solid Dispersions.

Authors: Noolkar SB, Jadhav NR, Bhende SA, Killedar SG Abstract The effect of ternary solid dispersions of poor water-soluble NSAID meloxicam with moringa coagulant (obtained by salt extraction of moringa seeds) and polyvinylpyrrolidone on the in vitro dissolution properties has been investigated. Binary (meloxicam-moringa and meloxicam-polyvinylpyrrolidone (PVP)) and ternary (meloxicam-moringa-PVP) systems were prepared by physical kneading and ball milling and characterized by Fourier transform infrared spectroscopy, differential scanning calorimetry, and X-ray diffractometry. The in vitro dissolution behavior of meloxicam from the different products was evaluated by means of United States Pharmacopeia type II dissolution apparatus. The results of solid-state studies indicated th...

The pharmacokinetics and effects of meloxicam, gabapentin, and flunixin in postweaning dairy calves following dehorning with local anesthesia

In this study, we compared the pharmacokinetic parameters and effect of preemptive analgesics administered to calves subjected to dehorning with local anesthesia. Holstein steers were randomly assigned to receive one of the following treatments per os (PO) or intravenously (IV) (n = 8/group): meloxicam (1 mg/kg PO), gabapentin (15 mg/kg PO), meloxicam (1 mg/kg), and gabapentin (15 mg/kg) PO, flunixin (2.2 mg/kg IV), or a placebo. Plasma drug, haptoglobin, substance P (SP) concentrations, serum cortisol concentrations, ocular thermography, mechanical nociceptive threshold (MNT), and average daily gain (ADG) were evaluated. Data were analyzed using mixed?effects models and noncompartmental pharmacokinetic analysis. Meloxicam, gabapentin, and meloxicam with gabapentin at the present ...

Combined zoledronic acid and meloxicam reduced bone loss and tumour growth in an orthotopic mouse model of bone?invasive oral squamous cell carcinoma

Abstract Oral squamous cell carcinoma (OSCC) is common in cats and humans and invades oral bone. We hypothesized that the cyclooxygenase (COX)?2 inhibitor, meloxicam, with the bisphosphonate, zoledronic acid (ZOL), would inhibit tumour growth, osteolysis and invasion in feline OSCC xenografts in mice. Human and feline OSCC cell lines expressed COX?1 and COX?2 and the SCCF2 cells had increased COX?2 mRNA expression with bone conditioned medium. Luciferase?expressing feline SCCF2Luc cells were injected beneath the perimaxillary gingiva and mice were treated with 0.1??mg??kg??1 ZOL twice weekly, 0.3??mg??kg??1 meloxicam daily, combined ZOL and meloxicam, or vehicle. ZOL inhibited osteoclastic bone resorption at the tumour??bone interface. Meloxicam was more effective than ZOL...

Pharmacokinetics of meloxicam after intravenous, intramuscular, and oral administration of a single dose to Hispaniolan Amazon parrots (Amazona ventralis).

CONCLUSIONS AND CLINICAL RELEVANCE: Pharmacokinetic data may provide useful information for use of meloxicam in Hispaniolan Amazon parrots. A mean plasma concentration of 3.5 μg/mL would be expected to provide analgesia in Hispaniolan Amazon parrots; however, individual variation may result in some birds having low plasma meloxicam concentrations after IV, IM, or oral administration. After oral administration, meloxicam concentration slowly reached the target plasma concentration, but that concentration was not sustained in most birds. PMID: 23438111 [PubMed - in process] (Source: American Journal of Veterinary Research)

[Meloxicam-induced colitis revealed by acute abdominal pain].

This report and a few other cases in the literature suggest that cyclooxygenase-2 selective non-steroidal anti-inflammatory drug inhibitor toxicity should be investigated in case of unexplained acute colitis. PMID: 23537413 [PubMed - in process] (Source: Annales Pharmaceutiques Francaises)<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>

A possible anaphylactoid reaction in a cow after intravenous meloxicam

(Source: Veterinary Anaesthesia and Analgesia)

OROCAM (Meloxicam) Spray, Metered [Abbott Laboratories]

Updated Date: Feb 25, 2013 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

Pharmacokinetics of meloxicam in koalas (Phascolarctos cinereus) after intravenous, subcutaneous and oral administration

This study demonstrated that koalas exhibited rapid CL and extremely poor oral bioavailability compared with other eutherian species. Accordingly, the currently recommended dose regimen of meloxicam for this species appears inadequate. (Source: Journal of Veterinary Pharmacology and Therapeutics)

MELOXICAM ( Meloxicam ) Tablet [Lake Erie Medical DBA Quality Care Products LLC]

Updated Date: Feb 14, 2013 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

Femoral fracture repair and sciatic and femoral nerve blocks in a guinea pig

Abstract A four?month?old, entire male guinea pig was presented for surgical repair of a closed oblique femoral fracture. Analgesia was provided with 30??µg/kg??buprenorphine intramuscularly (im) four times a day and 0??·??3??mg/kg meloxicam subcutaneously once a day. The following day, anaesthesia was induced and maintained with 100??µg/kg medetomidine im, 20??mg/kg ketamine im, 30??µg/kg buprenorphine im and isoflurane in oxygen. Femoral and sciatic nerve blocks were performed with bupivacaine. The fracture was reduced and aligned using an intramedullary 1??·??4??mm??K?wire and a 3 metric polydioxanone cerclage. Three weeks postoperatively remodelling and callus formation was documented, with no evidence of complications. Complete union was present 14??weeks posto...<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>

Effects of oral administration of anti-inflammatory medications on inhibition of paracentesis-induced blood-aqueous barrier breakdown in clinically normal cats.

Conclusions and Clinical Relevance-Orally administered prednisolone and meloxicam significantly decreased intraocular inflammation in clinically normal cats with paracentesis-induced BAB breakdown. Oral administration of prednisolone or meloxicam may be an effective treatment for cats with uveitis. PMID: 23363352 [PubMed - in process] (Source: American Journal of Veterinary Research)

Meloxicam as an adjuvant to peginterferon?α?2a and ribavirin treatment for genotype 1 chronic hepatitis C: A randomized trial

ConclusionMeloxicam enhanced antiviral efficacy and reduced the decline in neutrophil counts for the peginterferon and ribavirin treatment of genotype 1 chronic hepatitis C. This drug could be a reasonable adjuvant for the treatment of patients with chronic hepatitis C. The present study including a small number of patients warrants larger clinical trials. (Source: Hepatology Research)

Comparison of the Effects of Meloxicam and Dexketoprofen on Postoperative Adhesion Formation in a Rat Uterine Horn Surgical Model

Abstract: Study Objective: To compare the effects of 2 nonsteroidal antiinflammatory drugs of different chemical classes (meloxicam and dexketoprofen) on postoperative intraabdominal adhesion formation in a rat model.Design: Experimental study (Canadian Task Force classification I).Setting: Center for research and development.Animals: Thirty female Wistar albino rats.Interventions: The animals were randomly assigned to 1 of 3 groups (10 rats per group) and received intramuscular injections of 0.5 mg/kg dexketoprofen (group 1), 0.5 mg/kg meloxicam (group 2), or 1 mL sterile saline solution (control; group 3) daily for 2 days. Laparotomy was performed, and 1 of the uterine horns was damaged via monopolar electrocautery, whereas an incision was made in the other horn using a scalpel and was s...

Pharmacokinetics and Safety of Oral Administration of Meloxicam to Foals

Conclusions and clinical importanceMeloxicam at an oral dose rate of 0.6 mg/kg every 12 hours provided plasma concentrations likely to be therapeutic. In contrast to findings for other NSAIDs, foals appeared more resilient to the adverse effects of this drug than was observed in adult horses. (Source: Journal of Veterinary Internal Medicine)

METACAM (Meloxicam) Suspension [Boehringer Ingelheim Vetmedica, Inc.]

Updated Date: Dec 28, 2012 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>

Simultaneous determination for oxicam non-steroidal anti-inflammatory drugs in human serum by liquid chromatography??tandem mass spectrometry

Abstract: A high-performance liquid chromatography??tandem mass spectrometry (LC/MS/MS) technique was developed for the simultaneous determination of five non-steroidal anti-inflammatory oxicam drugs (ampiroxicam, tenoxicam, piroxicam, meloxicam and lornoxicam) in human plasma. These five oxicam drugs and isoxicam (internal standard) were extracted from human plasma with an Oasis® MAX cartridge column and analysed on a Unison UK-C18 column (2.0mm?100mm, 3μm) with an acetonitrile:10mM formic ammonium buffer (pH 3.0) (50:50) mobile phase at 0.20ml/min at 37°C. The analytes were detected using a tandem mass spectrometer, equipped with an electrospray ion source (ESI). The instrument was used in multiple-reaction-monitoring (MRM) mode.The extraction yields from a 200μl human plasma sampl...

LOXICOM (Meloxicam) Solution [Norbrook Laboratories Limited]

Updated Date: Dec 26, 2012 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

Sedative and analgesic effects of buprenorphine, combined with either acepromazine or dexmedetomidine, for premedication prior to elective surgery in cats and dogs

ConclusionChoice of dex or acp, when given with buprenorphine, caused minor, clinically detectable, differences in various characteristics of anaesthesia, but not in the level of analgesia. Clinical relevanceA combination of buprenorphine with either acp or dex, followed by either PRO or ALF, and then isoflurane, accompanied by an NSAID, was suitable for anaesthesia in dogs and cats undergoing elective surgery. Choice of sedative agent may influence dose of anaesthetic induction agent. (Source: Veterinary Anaesthesia and Analgesia)

Cortisol and Interferon Tau Regulation of Endometrial Function and Conceptus Development in Female Sheep.

Authors: Dorniak P, Welsh TH, Bazer FW, Spencer TE Abstract During early pregnancy in sheep, the elongating conceptus secretes interferon-? (IFNT) and the conceptus as well as endometrial epithelia produce prostaglandins (PG) via PG synthase 2 (PTGS2) and cortisol via hydroxysteroid (11-β) dehydrogenase 1 (HSD11B1). Ovarian progesterone induces and PG and IFNT stimulates endometrial HSD11B1 expression and keto-reductase activity as well as many epithelial genes that govern trophectoderm proliferation, migration, and attachment during elongation. The primary aim of these studies was to test the hypothesis that HSD11B1-derived cortisol has a biological role in endometrial function and conceptus development during early pregnancy in sheep. In study 1, cyclic ewes received vehicle, c...

Meloxicam as an adjuvant to peginterferon alfa?2a and ribavirin treatment for genotype 1 chronic hepatitis C: a randomized trial

ConclusionMeloxicam enhanced antiviral efficacy and reduced the decline in neutrophil counts for the peginterferon and ribavirin treatment of genotype 1 chronic hepatitis C. This drug could be a reasonable adjuvant for the treatment of patients with chronic hepatitis C. The present study including small number of patients warrants larger clinical trials. (Source: Hepatology Research)<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>

Meloxicam: Nephrotic syndrome and acute tubular necrosis: case report

(Source: Reactions)

Evaluation of Meloxicam-Loaded Cationic Transfersomes as Transdermal Drug Delivery Carriers.

Authors: Duangjit S, Opanasopit P, Rojanarata T, Ngawhirunpat T Abstract The aim of this study is to develop meloxicam (MX)-loaded cationic transfersomes as skin delivery carriers and to investigate the influence of formulation factors such as cholesterol and cationic surfactants on the physicochemical properties of transfersomes (i.e., particle size, size distribution, droplet surface charge and morphology), entrapment efficiency, stability of formulations and in vitro skin permeation of MX. The transfersomes displayed a spherical structure. Their size, charge, and entrapment efficiency depended on the composition of cholesterol and cationic surfactants in the formulation. Transfersomes provided greater MX skin permeation than conventional liposomes and MX suspensions. The penetra...

Effect of cyclooxygenase-2 inhibition by meloxicam, on atrogin-1 and myogenic regulatory factors in skeletal muscle of rats injected with endotoxin.

Authors: Martin AI, Nieto-Bona MP, Castillero E, Fernandez-Galaz C, Lopez-Menduina M, Gomez-Sanmiguel AB, Gomez-Moreira C, Villanua MA, Lopez-Calderon A Abstract Cyclooxygenase-2-induction by inflammatory stimuli has been proposed as a mediator of inflammatory cachexia. We analyse whether cyclooxygenase-2 inhibition by meloxicam administration is able to modify the response of skeletal muscle to inflammation induced by lipopolysaccharide endotoxin (LPS). Male rats were injected with 1 mg kg(-1) LPS at 17:00 h and at 10:00 h the following day, and euthanized 4, 24 or 72 hours later. Atrogin-1, MuRF1, myogenic regulatory factors and cyclooxygenase-2 in the gastrocnemius were determined by real time-PCR (mRNA) and Western blot (protein). In a second experiment the effect of meloxicam ...

Recovery from hematopoietic injury by modulating prostaglandin E(2) signaling post-irradiation.

Authors: Hoggatt J, Singh P, Stilger KN, Plett PA, Sampson CH, Chua HL, Orschell CM, Pelus LM Abstract While high dose total body irradiation (TBI) is used therapeutically, the proliferation of nuclear weapons, increasing use of nuclear power, and worldwide radical terrorism underscore the need to develop countermeasures to a radiological mass casualty event. The hematopoietic syndrome of the acute radiation syndrome (HS-ARS) results from severe compromise to the hematopoietic system, including lymphocytopenia, neutropenia, thrombocytopenia, and possible death from infection and/or hemorrhage. Given adequate time to recover, expand, and appropriately differentiate, bone marrow hematopoietic stem cells (HSC) and progenitor cells (HPC) may overcome HS-ARS and restore homeostasis of t...

Differential effect of transient global ischaemia on the levels of γ?aminobutyric acid type A (GABAA) receptor subunit mRNAs in young and older rats

Conclusions: The data indicate that I/R results in the modification of the levels of several gene transcripts involved in GABAergic signalling in both the pre? and postsynaptic components, of this neurotransmitter system, in an age? and structure?dependent manner. (Source: Neuropathology and Applied Neurobiology)<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>

Superoxide anion mediates the L-selectin down-regulation induced by non-steroidal anti-inflammatory drugs in human neutrophils.

CONCLUSION: A group of NSAIDs is capable of interfering with the ability of neutrophils to interact with endothelial cells by triggering L-selectin-shedding through the NADPH-oxidase-dependent generation of superoxide anion at the plasma membrane. PMID: 23142710 [PubMed - as supplied by publisher] (Source: Biochemical Pharmacology)

Effects of meloxicam on hematologic and plasma biochemical analysis variables and results of histologic examination of tissue specimens of Japanese quail (Coturnix japonica).

Conclusions and Clinical Relevance-Meloxicam (2.0 mg/kg, IM, q 12 h for 14 days) did not cause substantial alterations in function of or histopathologic findings for the kidneys of Japanese quail but did induce muscle necrosis; repeated IM administration of meloxicam to quail may be contraindicated. PMID: 23106456 [PubMed - in process] (Source: American Journal of Veterinary Research)

In vitro cytoprotective effects of acetylsalicylic acid, carprofen, meloxicam, or robenacoxib against apoptosis induced by sodium nitroprusside in canine cruciate ligament cells.

Conclusions and Clinical Relevance-Results indicated that carprofen, meloxicam, and robenacoxib may reduce apoptosis in cells originating from canine cruciate ligaments. PMID: 23106460 [PubMed - in process] (Source: American Journal of Veterinary Research)

Leflunomide increases the risk of silent liver fibrosis in patients with rheumatoid arthritis receiving methotrexate

IntroductionWe identified silent liver fibrosis in patients with rheumatoid arthritis (RA) using transient elastography, and investigated medication that correlated with abnormal liver stiffness measurement (LSM) values. Methods: We consecutively enrolled 105 patients with RA taking methotrexate over 24 weeks with normal liver functions and no history of underlying chronic liver disease. Blood tests were performed, and body mass index and metabolic syndrome were assessed. We checked LSM values, and adopted 5.3 kPa as the cutoff for abnormal LSM values. The cumulative doses of medications including methotrexate, leflunomide, sulfasalazine, hydroxychloroquine, prednisolone, meloxicam, and celecoxib were calculated. Results: The median age of patients (20 men and 85 women) was 52.4 years. The...

A comparison of abdominal and scrotal approach methods of vasectomy and the influence of analgesic treatment in laboratory mice

This study was undertaken to assess the validity of this recommendation. Mice underwent vasectomy via either abdominal or scrotal approach surgery. Mice were filmed for 15 min presurgery and at one, 24 and 48 h postsurgery. Data were obtained using automated behaviour recognition software (HomeCageScan). Meloxicam was administered either alone or combined with acetaminophen prior to surgery. A third group received only saline subcutaneously. Postsurgery behaviour changes were compared between groups at each time point. Exploratory behaviours such as rearing, walking and sniffing were most greatly reduced at one hour following surgery whereas the duration of grooming increased. By 48 h these changes had largely subsided. Results indicated mice undergoing scrotal approach surgery fared bette...<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>

Effects of Meloxicam and Phenylbutazone on Equine Gastric Mucosal Permeability

Conclusion and Clinical ImportanceThese results suggest that PBZ was associated with greater compromise to gastric mucosal integrity than meloxicam. (Source: Journal of Veterinary Internal Medicine)

Menthosomes, novel ultradeformable vesicles for transdermal drug delivery: optimization and characterization.

Authors: Duangjit S, Obata Y, Sano H, Kikuchi S, Onuki Y, Opanasopit P, Ngawhirunpat T, Maitani Y, Takayama K Abstract Menthosomes, novel deformable carriers for the enhancement of transdermal delivery are introduced in this study. Meloxicam (MX)-loaded menthosomes were formulated, and their physicochemical characteristics and skin permeability were evaluated. A two-factor spherical and second-order composite experimental design was used to prepare the formulation of the menthosomes. Ten formulations of menthosomes composed of a phospholipid as the lipid bilayer carrier, cholesterol (Chol) as a stabilizer and cetylpyridinium chloride (CPC) and L-menthol as penetration enhancers were prepared. The amounts of Chol and CPC were selected as causal factors. Physicochemical characteristi...

MELOXICAM (Meloxicam) Tablet [AvPAK]

Updated Date: Oct 15, 2012 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

MOBIC (Meloxicam) Tablet [PD-Rx Pharmaceuticals, Inc.]

Updated Date: Oct 9, 2012 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

Role of TNF?α in the Mechanisms Responsible for Preterm Delivery Induced by Stx2 in Rats

Conclusions And Implications.Our results demonstrate for the first time that the increase of TNF?α and NO produced by Stx2 are mostly responsible for the preterm delivery in rats. (Source: British Journal of Pharmacology)<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>

Pharmacokinetics and adverse effects of oral meloxicam tablets in healthy adult horses

The objective of this study was to assess the pharmacokinetic profile and determine whether any adverse effects would occur in seven healthy adult horses following oral meloxicam tablet administration once daily for 14 days at a dose of 0.6 mg/kg·bwt. Horses were evaluated for health using physical examination, complete blood count, serum chemistry, urinalysis, and gastroscopy at the beginning and end of the study. Blood was collected for the quantification of meloxicam concentrations with liquid chromatography and mass spectrometry. The mean terminal half?life was 4.99 ± 1.11 h. There was no significant difference between the mean Cmax, 1.58 ± 0.71 ng/mL at Tmax 3.48 ± 3.30 h on day 1, 2.07 ± 0.94 ng/mL at Tmax 1.24 ± 1.24 h on day 7, and 1.81 ± 0.76 ng/mL at ...

Abstracts

This report describes the deaths of 2 rainbow lorikeets and an eclectus parrot that developed minimal to no overt clinical signs over a 23-day period. The birds were housed in a mixed-species aviary. One of the lorikeets and the eclectus parrot were submitted for necropsy examination. The lorikeet was found on the aviary floor ataxic and unable to fly shortly before death. The eclectus parrot had been removed from the aviary because of cage-mate aggression and was being treated with dexamethasone, vitamins, and meloxicam before dying 3 days later with no overt clinical signs of illness. Sections of all organs from the necropsied birds were stained with hematoxylin-eosin and Gram's stain and submitted for histopathologic evaluation. Frozen sections of liver were submitted for bacterial cult...

The safety of codeine in patients with non-steroidal anti-inflammatory drug hypersensitivity: A preliminary study.

CONCLUSIONS: Although, codeine was among the safest alternative drugs and none of the patients had an anaphylactic reaction to it, thus a challenge with codeine may be considered especially in patients with dermographism. The results of this preliminary study should be confirmed in a prospective study including a control group. PMID: 23031656 [PubMed - as supplied by publisher] (Source: Allergologia et Immunopathologia)

Are drug provocation tests still necessary to test the safety of COX-2 inhibitors in patients with cross-reactive NSAID hypersensitivity?

CONCLUSION: Our results suggest to follow the traditional DPT method to introduce COX-2 inhibitors for finding safe alternatives in all patients with cross-reactive NSAID hypersensitivity before prescription as uncertainty of any predictive factor for a positive response continues. However, these tests should be performed in hospital settings in which emergency equipment and experienced personnel are available. PMID: 23031659 [PubMed - as supplied by publisher] (Source: Allergologia et Immunopathologia)

Target animal safety study of meloxicam administered via transmucosal oral spray (Promist® technology) for 6 months in dogs

This study evaluated the safety of meloxicam administered via transmucosal oral spray (TMOS) at 1, 2, 3 and 5 times the maximum proposed dose for 6 months in dogs. After baseline assessments, 40 Beagles (20 M, 20 F) were randomized to gender?balanced groups administered either water or meloxicam TMOS at 1, 2, 3 and 5 times the maximum proposed dose once daily for 26 weeks. Dogs were subjected to daily food consumption measurements and clinical and dose site observations. Periodic evaluations were made of body weight, physical examination, clinical pathology, urinalysis, buccal mucosal bleeding time (BMBT) and gastroduodenal endoscopy. At study completion, all dogs were subjected to gross necropsy. Histopathology was performed on tissues from dogs in groups 0X and 5X and from selected...<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>

Exploring the cyclooxygenase 2 (COX2)/15d-?(12,14)PGJ(2) system in hamster Sertoli cells: Regulation by FSH/testosterone and relevance to glucose uptake.

In this study, we investigated the existence of a COX2/PGs system in hamster Sertoli cells, its regulation by testosterone and FSH, and its effect on glucose uptake. COX2 expression was observed in Sertoli cells of both reproductively active and inactive adult hamsters. Testosterone and the plasma membrane-impermeable testosterone-BSA significantly induced COX2 expression, mitogen activated protein kinases 1/2 (MAPK1/2) phosphorylation and 15d-?(12,14)PGJ(2) production in Sertoli cells purified from photoperiodically regressed hamsters. These actions were abolished by the antiandrogen bicalutamide and by the inhibitor of MAPK kinase (MEK1/2) U0126, suggesting that testosterone exerts its stimulatory effect on COX2/PGs through a non-classical mechanism that involves the presence of androge...

Induction of P?glycoprotein and Bcrp at the rat blood??brain barrier following a subchronic morphine treatment is mediated through NMDA/COX?2 activation

This study investigates the rate and extent to which P?gp and breast cancer?resistance protein (Bcrp) increase at the rat blood??brain barrier following subchronic morphine treatment. Rats were given increasing doses of morphine (10??40 mg/kg) or saline i.p. twice daily for 5 days. The brain cortex large vessels and microvessels were then mechanical isolated 6, 9, 12, 24, and 36 h after the last injection. The gene and protein expression of P?gp and Bcrp in morphine?treated and control rats were compared by qRT?PCR and western blotting. The levels of Mdr1a and Bcrp mRNAs were not significantly modified 6 h post morphine, but the Mdr1a mRNA increased 1.4?fold and Bcrp mRNA 2.4?fold at 24 h. P?gp and Bcrp protein expression in brain microvessels was unchanged 6 h post...

Pharmacokinetics and effect of intravenous meloxicam in weaned Holstein calves following scoop dehorning without local anesthesia

Calves treated with meloxicam, without local anesthetic, prior to dehorning demonstrate significantly lower plasma substance P concentrations alongside other markers for distress, demonstrating the potential for reducing pain perception using non-steroidal anti-inflammatory drugs. (Source: BMC Veterinary Research - Latest articles)

METACAM (Meloxicam) Suspension [Boehringer Ingelheim Vetmedica, Inc.]

Updated Date: Aug 30, 2012 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

Influence of weight gain on casual glucose levels: a study of children and adolescents enrolled in public schools in Salvador, BA, Brazil

A 19-year-old female with type 1 diabetes for four years, and a 73-year-old female with type 2 diabetes for twenty years developed sudden-onset nephrotic syndrome. Examination by light microscopy, immunofluorescence, and electron microscopy (in one case) identified minimal change disease (MCD) in both cases. There was a potential causative drug (meloxicam) for the 73-year-old patient. Both patients were treated with prednisone and responded with complete remission. The patient with type 1 diabetes showed complete remission without relapse, and the patient with type 2 diabetes had two relapses; complete remission was sustained after associated treatment with cyclophosphamide and prednisone. Both patients had two years of follow-up evaluation after remission. We discuss the outcomes of both ...<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>

Ablation of thyroid remnant with 30 mCi 131I in&nbsp;thyroid&nbsp;cancer patients prepared with recombinant human TSH

A 19-year-old female with type 1 diabetes for four years, and a 73-year-old female with type 2 diabetes for twenty years developed sudden-onset nephrotic syndrome. Examination by light microscopy, immunofluorescence, and electron microscopy (in one case) identified minimal change disease (MCD) in both cases. There was a potential causative drug (meloxicam) for the 73-year-old patient. Both patients were treated with prednisone and responded with complete remission. The patient with type 1 diabetes showed complete remission without relapse, and the patient with type 2 diabetes had two relapses; complete remission was sustained after associated treatment with cyclophosphamide and prednisone. Both patients had two years of follow-up evaluation after remission. We discuss the outcomes of both ...

Minimal change disease associated with type 1 and type 2 diabetes mellitus

A 19-year-old female with type 1 diabetes for four years, and a 73-year-old female with type 2 diabetes for twenty years developed sudden-onset nephrotic syndrome. Examination by light microscopy, immunofluorescence, and electron microscopy (in one case) identified minimal change disease (MCD) in both cases. There was a potential causative drug (meloxicam) for the 73-year-old patient. Both patients were treated with prednisone and responded with complete remission. The patient with type 1 diabetes showed complete remission without relapse, and the patient with type 2 diabetes had two relapses; complete remission was sustained after associated treatment with cyclophosphamide and prednisone. Both patients had two years of follow-up evaluation after remission. We discuss the outcomes of both ...

Allopurinol/ciprofloxacin/meloxicam: Toxic epidermal necrolysis: case report

(Source: Reactions)

Interference of NSAIDs with the thrombocyte inhibitory effect of aspirin: A placebo-controlled, ex vivo, serial placebo-controlled serial crossover study

Conclusions&nbsp;&nbsp;COX-1 affinity determines the interaction between NSAIDs and ASA on thrombocyte adhesion and aggregation. Ibuprofen and naproxen, but not etoricoxib or meloxicam, taken 2&nbsp;h before ASA, significantly inhibit ASA??s antithrombocyte effect. Content Type Journal ArticleCategory PharmacodynamicsPages 1-7DOI 10.1007/s00228-012-1370-yAuthors I. L. Meek, Arthritis Center Twente, University Twente and Medisch Spectrum Twente, 7500KA Enschede, NetherlandsH. E. Vonkeman, Arthritis Center Twente, University Twente and Medisch Spectrum Twente, 7500KA Enschede, NetherlandsJ. Kasemier, Arthritis Center Twente, University Twente and Medisch Spectrum Twente, 7500KA Enschede, NetherlandsK. L. L. Movig, Arthritis Center Twente, University Twente and Medisch Spectrum T...

Intramuscular stimulation therapy for healthcare: a systematic review of randomised controlled trials.

CONCLUSIONS: Despite the positive results of these individual studies, the level of evidence supporting the efficacy and effectiveness of IMS for several conditions remains insufficient because of concerns about a lack of precision and a high risk of bias of the included studies. Rigorous large-scale clinical trials of IMS are needed to evaluate the clinical utility of this technique. PMID: 22871295 [PubMed - as supplied by publisher] (Source: Acupuncture in Medicine : journal of the British Medical Acupuncture Society)<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>

Cyclooxygenase-independent neuroprotective effects of aspirin against dopamine quinone-induced neurotoxicity.

Authors: Asanuma M, Miyazaki I, Kikkawa Y, Kimoto N, Takeshima M, Murakami S, Miyoshi K Abstract Prostaglandin H synthase exerts not only cyclooxygenase activity but also peroxidase activity. The latter activity of the enzyme is thought to couple with oxidation of dopamine to dopamine quinone. Therefore, it has been proposed that cyclooxygenase inhibitors could suppress dopamine quinone formation. In the present study, we examined effects of various cyclooxygenase inhibitors against excess methyl L-3,4-dihydroxyphenylalanine (L-DOPA)-induced quinoprotein (protein-bound quinone) formation and neurotoxicity using dopaminergic CATH.a cells. The treatment with aspirin inhibited excess methyl L-DOPA-induced quinoprotein formation and cell death. However, acetaminophen did not show prote...

Pharmacokinetics and Safety of Single and Multiple Oral Doses of Meloxicam in Adult Horses

Conclusions and Clinical ImportanceAdministration meloxicam at 0.6 mg/kg q24h was well tolerated for 6 weeks, without drug accumulation in plasma. Higher doses were associated with dose?dependent adverse effects typical of class of drugs. (Source: Journal of Veterinary Internal Medicine)

Risk of upper gastrointestinal complications in a cohort of users of nimesulide and other nonsteroidal anti?inflammatory drugs in Friuli Venezia Giulia, Italy

ConclusionsIRs of UGIC in FVG decreased about 50% between 2001 and 2008. Nimesulide was in the low??medium range of RR. A complete ascertainment of UGIC cases in databases may require validation of nonspecific codes, secondary codes, and additional codes such as peritonitis and acute posthemorrhagic anemia. Copyright © 2012 John Wiley & Sons, Ltd. (Source: Pharmacoepidemiology and Drug Safety)

Induction of P?glycoprotein and Bcrp at the rat blood?brain barrier following a subchronic morphine treatment is mediated through NMDA/COX?2 activation.

This study investigates the rate and extent to which P?gp and Bcrp increase at the rat BBB following subchronic morphine treatment. Rats were given increasing doses of morphine (10 ?? 40 mg/kg) or saline i.p. twice daily for 5 days. The brain cortex large vessels and microvessels were then mechanical isolated 6, 9, 12, 24, and 36 h after the last injection. The gene and protein expression of P?gp and Bcrp in morphine?treated and control rats were compared by qRT?PCR and Western blotting. The levels of Mdr1a and Bcrp mRNAs were not significantly modified 6h post?morphine but the Mdr1a mRNA increased 1.4?fold and Bcrp mRNA 2.4?fold at 24 h. P?gp and Bcrp protein expression in brain microvessels was unchanged 6 h post?morphine and increased 1.5?fold at 24 h. This effect w...

Development and validation of two multiresidue liquid chromatography tandem mass spectrometry methods based on a versatile extraction procedure for isolating non-steroidal anti-inflammatory drugs from bovine milk and muscle tissue.

Authors: Gentili A, Caretti F, Bellante S, Mainero Rocca L, Curini R, Venditti A Abstract The main difficulties in analysing non-steroidal anti-inflammatory drugs (NSAIDs) in food and biological samples are due to the tight non-covalent interactions established with matrix proteins and the amount of occurring fatty material. The present paper describes an effective extraction procedure able to isolate fifteen NSAIDs (acetaminophen, salicylic acid, ibuprofen, diclofenac, flunixin and its metabolite 5-hydroxy-flunixin, nimesulide, phenylbutazone, meclofenamic acid, tolfenamic acid, meloxicam, carprofen, ketoprofen, naproxen and etodolac) from bovine milk and muscle tissue through two succeeding steps: (a) deproteinisation/extraction with organic solvent, essential to lower the medium...<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>

Anaesthetic complications in pigs undergoing MRI guided convection enhanced drug delivery to the brain: a case series

Conclusions?? Hypothermia is common in pigs undergoing this sedation and anaesthesia protocol. Convection enhanced delivery of drugs in healthy anaesthetized pigs may result in tachycardia. (Source: Veterinary Anaesthesia and Analgesia)

Methadone in combination with acepromazine as premedication prior to neutering in the cat

Conclusion and clinical relevance?? Methadone provided comparable sedation and analgesia to both buprenorphine and butorphanol when combined with acepromazine. Differences in analgesic efficacy between opioids might have been undetectable because of the surgical model and surgeon competency. Nevertheless, methadone is an effective analgesic in cats and its administration prior to feline neutering may be advantageous. (Source: Veterinary Anaesthesia and Analgesia)

Bioavailability and pharmacokinetics of oral meloxicam in llamas

Conclusions: The mean bioavailability (F) of oral meloxicam was 76% indicating a high degree of gastrointestinal absorption. Plasma meloxicam concentrations >0.2 mug/mL were maintained for up to 72 h after oral administration; >0.2 mug/mL is considered to be the concentration of meloxicam required for analgesic effects in other species such as the horse. These data suggest that a single dosage of oral meloxicam at 1 mg/kg could potentially maintain therapeutic concentrations in plasma for up to 3 days in adult llamas. (Source: BMC Veterinary Research - Latest articles)

Improving Solubility and Pharmacokinetics of Meloxicam via Multiple-Component Crystal Formation

Molecular PharmaceuticsDOI: 10.1021/mp300169c (Source: Molecular Pharmaceutics)

Nonsteroidal anti?inflammatory drugs and the risk of skin cancer

CONCLUSIONS:The current results indicated that NSAID use may decrease the risk of SCC and MM. Cancer 2012. © 2012 American Cancer Society. (Source: Cancer)<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>

Comparison of the effects of IV administration of meloxicam, carprofen, and flunixin meglumine on prostaglandin E(2) concentration in aqueous humor of dogs with aqueocentesis-induced anterior uveitis.

CONCLUSIONS AND CLINICAL RELEVANCE: Flunixin meglumine was more effective than meloxicam or carprofen for minimizing the PGE(2) concentration in the aqueous humor of dogs with experimentally induced uveitis. Flunixin meglumine may be an appropriate pre-medication for use prior to intraocular surgery in dogs. PMID: 22533402 [PubMed - in process] (Source: American Journal of Veterinary Research)

Assessment of behavioral changes associated with oral meloxicam administration at time of dehorning in calves using a remote triangulation device and accelerometers

Conclusions: The noted behavioral changes provide evidence of differences associated with meloxicam administration. More studies need to be performed to evaluate the relationship of behavior monitoring and post-operative pain. To our knowledge this is the first published report demonstrating behavioral changes following dehorning using a remote triangulation device in conjunction with accelerometers. (Source: BMC Veterinary Research - Latest articles)

Bioequivalence in dogs of a meloxicam formulation administered as a transmucosal oral mist with an orally administered pioneer suspension product

Lees, P., Cheng, Z., Keefe, T. J., Weich, E., Bryd, J., Cedergren, R., Cozzi, E. Bioequivalence in dogs of a meloxicam formulation administered as a transmucosal oral mist with an orally administered pioneer suspension product. J. vet. Pharmacol. Therap. doi: 10.1111/j.1365?2885.2012.01402.x.A mucosal mist formulation of meloxicam, administered as a spray into the mouth (test article), was compared for bioequivalence to a pioneer meloxicam suspension for oral administration (reference article). Pharmacokinetic profiles and average bioequivalence were investigated in 20 dogs. The study design comprised a two?period, two?sequence, two?treatment cross?over design, with maximum concentration (Cmax) and area under plasma concentration??time curve to last sampling time (AUClast) used ...

Evaluating a novel analgesic strategy for ring castration of ram lambs

Conclusions and clinical relevance?? Locally administered NSAIDs provided partial analgesia for ring castration. (Source: Veterinary Anaesthesia and Analgesia)<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>

Premedication with meloxicam exacerbates intracranial haemorrhage in an immature swine model of non-impact inertial head injury

Meloxicam is a cyclo-oxygenase-2 (COX-2) preferential non-steroidal anti-inflammatory drug with very effective analgesic and anti-inflammatory effects in swine. Previous reports in piglets have demonstrated that meloxicam also inhibits COX-1 and reduces production of thromboxane significantly. We use preinjury analgesia in our immature swine (3&ndash;5-day-old piglets) model of brain injury using rapid head rotations without impact. In 23 consecutive subjects we found that premedication with meloxicam (n = 6) produced a significantly higher mortality rate (5/6 or 83%) than buprenorphine (n = 17, 1/17 or 6%, P &lt; 0.02). On gross neuropathological examination of the meloxicam-treated swine, we observed massive subdural and subarachnoid bleeding which were not present in buprenorphine-preme...

Dispensed Selective and Nonselective Nonsteroidal Anti-inflammatory Drugs and the Risk of Moderate to Severe Hyperkalemia: A Nested Case-Control Study

Conclusions: NSAIDs may not by themselves carry a higher risk of moderate to severe hyperkalemia. Certain NSAIDs may increase the risk of hyperkalemia, but it is not related to COX-2 selectivity of the NSAID and may depend on concurrent exposure to other agents. (Source: American Journal of Kidney Diseases)

Meloxicam: Fixed drug eruption: case report

(Source: Reactions)

A randomized, single-blind comparison of the efficacy and tolerability of hyaluronate acid and meloxicam in adult patients with Kashin-Beck disease of the knee.

This study suggests that intra-articular injection of HA and administration of oral meloxicam should be efficacious and well tolerated in the treatment of knee pain due to KBD; the onset of action of meloxicam was faster than that of HA, whereas HA therapy resulted in a more prolonged increasing improvement of symptoms than meloxicam. In addition, HA treatment was likely superior to meloxicam with respect to tolerability. Other randomized double-blind studies are needed to confirm the findings of our open-label study. PMID: 22476807 [PubMed - as supplied by publisher] (Source: Pain Physician)

A randomized, single-blind comparison of the efficacy and tolerability of hyaluronate acid and meloxicam in adult patients with Kashin??Beck disease of the knee

This study suggests that intra-articular injection of HA and administration of oral meloxicam should be efficacious and well tolerated in the treatment of knee pain due to KBD; the onset of action of meloxicam was faster than that of HA, whereas HA therapy resulted in a more prolonged increasing improvement of symptoms than meloxicam. In addition, HA treatment was likely superior to meloxicam with respect to tolerability. Other randomized double-blind studies are needed to confirm the findings of our open-label study. Content Type Journal ArticleCategory Original ArticlePages 1-8DOI 10.1007/s10067-012-1979-3Authors Xin Tang, Department of Orthopaedic surgery, West China Hospital of Sichuan University, No. 37, Guoxue Alley, Chengdu, 610041 People??s Republic of ChinaFu-Xing Pei,...<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>

Neuroprotective Effects of Meloxicam and Selegiline in Scopolamine-Induced Cognitive Impairment and Oxidative Stress

Alzheimer&#39;s disease (AD) is a progressive neurodegenerative disorder characterized by a gradual decline in memory associated with shrinkage of brain tissue, with localized loss of neurons mainly in the hippocampus and basal forebrain, with diminished level of central cholinergic neurotransmitter-acetylcholine and also reported to be associated with accumulation of ubiquitinated proteins in neuronal inclusions and also with signs of inflammation. In these disorders, the abnormal protein aggregates may themselves trigger the expression of inflammatory mediators, such as cyclooxygenase 2 (COX-2). In the present study, the effects of Meloxicam, Selegiline, and coadministration of these drugs on scopolamine-induced learning and memory impairments in mice were investigated. Rectangular maze ...

MOBIC (Meloxicam) Suspension MOBIC (Meloxicam) Tablet [Boehringer Ingelheim Pharmaceuticals, Inc.]

Updated Date: Mar 20, 2012 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

The effects of age, isoflurane and sevoflurane on atracurium in lambs

Conclusions and clinical relevance?? The effect of atracurium is age?dependent in lambs being prolonged in older animals. The onset of neuromuscular blockade is more rapid in isoflurane compared with sevoflurane?anaesthetized lambs. (Source: Veterinary Anaesthesia and Analgesia)

Determination of non-steroidal anti-inflammatory drugs and their metabolites in milk by liquid chromatography-tandem mass spectrometry.

Authors: Jedziniak P, Szprengier-Juszkiewicz T, Pietruk K, Sledzi?ska E, Zmudzki J Abstract Non-steroidal anti-inflammatory drugs are widely used for treatment of animals. According to Council Directive 96/23/EC, residues of these drugs must be monitored because of the potential risk they pose to the consumers' health. For this reason an LC-MS-MS method was developed for detection of wide range of NSAIDs, including both "acidic" NSAIDs (carprofen, diclofenac, flunixin, meloxicam, phenylbutazone, oxyphenbutazone, tolfenamic acid, mefenamic acid, naproxen, ketoprofen, ibuprofen, firocoxib, rofecoxib, and celecoxib) and "basic" NSAIDs (four metamizole metabolites). Analytes were extracted from milk samples with acetonitrile in the presence of ammonium acetate. One portion of the extr...<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>

Analgesic effects of meloxicam administration on postoperative orthopedic pain in domestic pigeons (Columba livia).

Conclusions and Clinical Relevance-Administration of meloxicam at 0.5 mg/kg appeared ineffective in minimizing postoperative orthopedic pain in pigeons, but the 2.0 mg/kg dose provided quantifiable analgesia that appeared safe in this species in experimental conditions. PMID: 22369527 [PubMed - in process] (Source: American Journal of Veterinary Research)

Efficacy and safety of 3 versus 5 days of meloxicam as an analgesic for feline onychectomy and sterilization.

Authors: Ingwersen W, Fox R, Cunningham G, Winhall M Abstract Three- or 5-day courses of meloxicam [0.2 mg/kg body weight (BW) subcutaneously pre- or postoperatively on Day 1 followed by 0.05 mg/kg BW, PO per day thereafter] were assessed for analgesic efficacy and safety in 50 client-owned cats undergoing onychectomy and sterilization. Primary outcome parameters were analgesia score, gait/lameness score, and need for rescue analgesia assessed at times 0, 1, 4, 7, 24, 28, 35, 48, 52, 57 hours and on Day 5. Packed cell volume/total solids and serum biochemistry were assessed at time 0 and Days 3 and 5. There were no differences in efficacy and safety parameters regardless of the treatment protocol employed and no cat required rescue analgesia. The patients that received meloxicam pr...

Clinical effects of isoflurane and sevoflurane in lambs

Conclusion?? Isoflurane and sevoflurane are both suitable for maintaining general anaesthesia in lambs although sevoflurane, as used in this study, allows a more rapid reunion with the ewe.Clinical relevance?? The principal advantage of sevoflurane over isoflurane during prolonged anaesthesia in lambs is a more rapid recovery. (Source: Veterinary Anaesthesia and Analgesia)

Meloxicam: First report of rhabdomyolysis in an elderly patient: case report

(Source: Reactions)

Pharmacokinetics and milk secretion of gabapentin and meloxicam co?administered orally in Holstein?Friesian cows

This study was designed to determine specifically the depletion of these drugs into milk. Six animals received meloxicam at 1??mg/kg and gabapentin at 10??mg/kg, while another group (n??=??6) received meloxicam at 1??mg/kg and gabapentin at 20??mg/kg. Plasma and milk drug concentrations were determined over 7??days postadministration by HPLC/MS followed by noncompartmental pharmacokinetic analyses. The mean (±SD) plasma Cmax and Tmax for meloxicam (2.89??±??0.48??μg/mL and 11.33??±??4.12??h) were not much different from gabapentin at 10??mg/kg (2.87??±??0.2??μg/mL and 8??±??0??h). The mean (±SD) milk Cmax for meloxicam (0.41??±??80.16??μg/mL) was comparable to gabapentin at 10??mg/kg (0.63??±??0.13??μg/mL and 12??±??6.69??h). The mean plasma and m...<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>

Moringa Coagulant as a Stabilizer for Amorphous Solids: Part I.

Authors: Bhende S, Jadhav N Abstract Stabilization of amorphous state is a focal area for formulators to reap benefits related with solubility and consequently bioavailability of poorly soluble drugs. In the present work, an attempt has been made to explore the potential of moringa coagulant as an amorphous state stabilizer by investigating its role in stabilization of spray-dried (amorphous) ibuprofen, meloxicam and felodipine. Thermal studies like glass forming ability, glass transition temperature, hot stage microscopy and DSC were carried out for understanding thermodynamic stabilization of drugs. PXRD and dissolution studies were performed to support contribution of moringa coagulant. Studies showed that hydrogen bonding and electrostatic interactions between drug and moringa ...

Aspirin, steroidal and non-steroidal anti-inflammatory drugs for the treatment of Alzheimer's disease.

CONCLUSIONS: Based on the studies carried out so far, the efficacy of aspirin, steroid and NSAIDs (traditional NSAIDs and COX-2 inhibitors) is not proven. Therefore, these drugs cannot be recommended for the treatment of AD. PMID: 22336816 [PubMed - in process] (Source: Cochrane Database of Systematic Reviews)

Meloxicam: Depressive psychosis: case report

(Source: Reactions)

Pharmacokinetics and milk secretion of gabapentin and meloxicam co?administered orally in Holstein?Friesian cows

This study was designed to determine specifically the depletion of these drugs into milk. Six animals received meloxicam at 1??mg/kg and gabapentin at 10??mg/kg, while another group (n??=??6) received meloxicam at 1??mg/kg and gabapentin at 20??mg/kg. Plasma and milk drug concentrations were determined over 7??days postadministration by HPLC/MS followed by noncompartmental pharmacokinetic analyses. The mean (±SD) plasma Cmax and Tmax for meloxicam (2.89??±??0.48??μg/mL and 11.33??±??4.12??h) were not much different from gabapentin at 10??mg/kg (2.87??±??0.2??μg/mL and 8??±??0??h). The mean (±SD) milk Cmax for meloxicam (0.41??±??80.16??μg/mL) was comparable to gabapentin at 10??mg/kg (0.63??±??0.13??μg/mL and 12??±??6.69??h). The mean plasma and m...

Differential effect of transient global ischaemia on the levels of GABAA receptor subunit mRNAs in young and older rats

Conclusions: The data indicate that I/R results in the modification of the levels of several gene transcripts involved in GABAergic signalling in both the pre? and postsynaptic components, of this neurotransmitter system, in an age? and structure?dependent manner.© 2012 The Authors. Neuropathology and Applied Neurobiology © 2012 British Neuropathological Society (Source: Neuropathology and Applied Neurobiology)<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>

Is a nonsteroidal anti-inflammatory drug required to alleviate pain behavior associated with liver biopsy in cattle?

Abstract: Liver samples are collected from cattle for a variety of reasons. Samples are taken by percutaneous biopsy, and, as this causes pain in cattle, it is usually performed under local anesthesia (LA). However, postbiopsy inflammation can cause pain and sensitization of the wound site after the effects of LA have worn off. If significant, inflammatory pain has the potential to affect animal welfare and productivity. Eighteen Friesian heifers and cows (mean body weight = 534 kg) were used in this study; all received LA at the incision site. Six animals were biopsied with no further drug administration (LA), 6 were given 15 mL meloxicam intravenously and then biopsied (LAN), and 6 were sham-biopsied (control, C). Paddock behavior was observed for 4 hours after biopsy: totals for the who...

Differential effect of transient global ischaemia on the levels of GABAA receptor subunit mRNAs in young and older rats

Conclusions: The data indicate that I/R results in the modification of the levels of several gene transcripts involved in GABAergic signalling in both the pre? and postsynaptic components, of this neurotransmitter system, in an age? and structure?dependent manner.© 2012 The Authors. Neuropathology and Applied Neurobiology © 2012 British Neuropathological Society (Source: Neuropathology and Applied Neurobiology)

Binding of Cu(II) complexes of oxicam NSAIDs to alternating AT and homopolymeric AT sequences: differential response to variation in backbone structure.

Authors: Chakraborty S, Sehanobish E, Sarkar M Abstract Besides their principal functions as painkillers and anti-inflammatory agents, drugs belonging to the nonsteroidal anti-inflammatory drug (NSAID) group also have anticancer properties. Cu(II) complexes of these drugs enhance the anticancer effect. How they exert this effect is not clear. As a possible molecular mechanism, our group has already shown that the Cu(II) complexes of two oxicam NSAIDs with anticancer properties, viz. piroxicam and meloxicam, can directly bind to the DNA backbone. AT stretches are abundant in the eukaryotic genome. These stretches are more accessible to binding of different ligands, resulting in expression of different functions. AT stretches containing both alternating base pairs and homopolymeric b...

Effects of carprofen, meloxicam and deracoxib on platelet function in dogs

Conclusions and clinical relevance?? Oral administration of some COX?2 selective NSAIDs causes detectable alterations in platelet function in dogs. As in humans, PFA?100 collagen/ADP cartridges do not reliably detect COX?mediated platelet dysfunction in dogs. Individual assessment of platelet function is advised when administering these drugs prior to surgery, particularly in the presence of other risk factors for bleeding. (Source: Veterinary Anaesthesia and Analgesia)

Cytoprotective effect of nonsteroidal antiinflammatory drugs in rat brain slices subjected to reoxygenation after oxygen-glucose deprivation.

In conclusion, NSAIDs with the greatest cytoprotective effect (nimesulide, celecoxib and meloxicam) may exert their effect mainly through the blockade of cyclooxygenase-2 (COX-2) activity. Other compounds with neuroprotective activity may complement their lower anti-COX-2 effect with a slight increase in interleukin 10 and reduced oxidative and nitrosative stress in our model of hypoxia-reoxygenation in rat brain slices. PMID: 22245539 [PubMed - as supplied by publisher] (Source: European Journal of Pharmaceutical Sciences)

Pre-emptive analgesia with the combination of tramadol plus meloxicam for third molar surgery: a pilot study

In conclusion, the study showed that the combination of tramadol 25mg and meloxicam 7.5mg had an analgesic effect similar to that of meloxicam 15mg, but both were better than tramadol 50mg for relief of pain after the extraction of mandibular third molars. (Source: The British Journal of Oral and Maxillofacial Surgery)

Endometrial HSD11B1 and Cortisol Regeneration in the Ovine Uterus: Effects of Pregnancy, Interferon Tau, and Prostaglandins.

Authors: Dorniak P, Welsh TH, Bazer FW, Spencer TE Abstract In ruminants, the elongating conceptus secretes interferon tau (IFNT), the pregnancy recognition signal, and prostaglandins (PGs). Progesterone from the ovary induces prostaglandin synthase two (PTGS2) and hydroxysteroid (11-beta) dehydrogenase 1 (HSD11B1) in the endometrial epithelia, and PTGS2-derived prostaglandins (PGs) regulate endometrial functions and conceptus elongation. The enzyme HSD11B1 interconverts inactive cortisone and active cortisol. These studies determined effects of pregnancy, IFNT, and PGs on endometrial HSD11B1 expression and activity in the ovine uterus. Study One found that HSD11B1 activity was present in both the endometrium and conceptus during early pregnancy. In Study Two, ewes received intraut...

Small bowel injury induced by selective cyclooxygenase-2 inhibitors: a prospective, double-blind, randomized clinical trial comparing celecoxib and meloxicam

Conclusions&nbsp;&nbsp;Selective COX-2 inhibitors are not completely safe for the small bowel. The mucosal lesions may be less severe with celecoxib than with meloxicam. Content Type Journal ArticleCategory Original Article??Alimentary TractPages 1-7DOI 10.1007/s00535-011-0501-zAuthors Yuji Maehata, Department of Medicine and Clinical Science, Graduate School of Medical Sciences, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka, 812-8582 JapanMotohiro Esaki, Department of Medicine and Clinical Science, Graduate School of Medical Sciences, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka, 812-8582 JapanToshibumi Morishita, Department of Medicine and Clinical Science, Graduate School of Medical Sciences, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka, 812-858...

Oxicam structure in non-steroidal anti-inflammatory drugs is essential to exhibit Akt-mediated neuroprotection against 1-methyl-4-phenyl pyridinium-induced cytotoxicity.

In this study, we therefore investigated the structure-specific for eliciting the neuroprotective effect by examining a series of NSAIDs against MPP(+) toxicity in SH-SY5Y cells. Three oxicam-bearing NSAIDs showed potent neuroprotective effects, although none of the other 10 oxicam-nonbearing NSAIDs (3 salicylates, 6 coxibs and 1 polyphenol) or 3 piroxicam analogs (including ampiroxicam, a precursor of piroxicam) exerted any neuroprotection. Tenoxicam and piroxicam prevented MPP(+)-induced reduction of phosphorylated Akt levels in cells: a protective mechanism similar to that of meloxicam. Therefore, the oxicam structure was likely to be responsible for exhibiting the neuroprotection by sustaining survival-signaling in dopaminergic cells. The present results raise the possibility that the ...<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>

Spontaneous adverse event reports of Stevens??Johnson syndrome/toxic epidermal necrolysis: detecting associations with medications

ConclusionsThere was good concordance between the reporting frequencies observed in the FDA AERS database and the published risk estimation of medications implicated in SJS/TEN. Copyright © 2011 John Wiley & Sons, Ltd. (Source: Pharmacoepidemiology and Drug Safety)

Preparation and In Vitro/In Vivo Evaluation of Microparticle Formulations Containing Meloxicam.

In this study, we have formulated chitosan-coated sodium alginate microparticles containing meloxicam (MLX) and aimed to investigate the correlation between in vitro release and in vivo absorbed percentages of meloxicam. The microparticle formulations were prepared by orifice ionic gelation method with two different sodium alginate concentrations, as 1% and 2% (w/v), in order to provide different release rates. Additionally, an oral solution containing 15 mg of meloxicam was administered as the reference solution for evaluation of in vitro/in vivo correlation (ivivc). Following in vitro characterization, plasma levels of MLX and pharmacokinetic parameters [elimination half-life (t (1/2)), maximum plasma concentration (C (max)), time for C (max) (t (...

Stroke risk and NSAIDs: an Australian population-based study

Source: The Medical Journal of Australia Area: News According to the results of a retrospective cohort study published in the Medical Journal of Australia, incident use of NSAIDs was associated with an increased stroke risk.&#160; The absolute risk of stroke was low however; and the resultant absolute increase was therefore also small.&#160; &#160; The authors note that most of the studies evaluating the use of NSAIDs and the risk of cardiovascular events have looked at a combined endpoint; few have examined the specific association of their use with the risk of stroke.&#160; They analysed data from the Department of Veterans' Affairs administrative claims database (from 2001-2008) to determine the association between hospitalisation for stroke and the prescription of NSAIDs in the Au...

Dose Reduction of Meloxicam in Dogs with Osteoarthritis?Associated Pain and Impaired Mobility

Conclusion and Clinical RelevanceDose reduction is a less effective means of pain control compared with maintained dosing. However, NSAID dose reduction with maintained efficacy is possible, but success appears to be individual dog dependent. (Source: Journal of Veterinary Internal Medicine)

Are meloxicam dimers really the structure-forming units in the 'meloxicam-carboxylic acid' co-crystals family? Relation between crystal structures and dissolution behaviour

CrystEngComm, 2011, Advance ArticleDOI: 10.1039/C1CE05902E, PaperNikolay A. Tumanov, Svetlana A. Myz, Tatyana P. Shakhtshneider, Elena V. BoldyrevaImproved dissolution of meloxicam co-crystals as compared to poorly soluble meloxicam is related to the presence of H-bonded meloxicam dimers in the crystals of meloxicam and their absence in co-crystals.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - CrystEngComm latest articles)<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>

Meloxicam depot injection proven to treat pain and inflammation

Encore Therapeutics (ETI) has successfully completed a pre-clinical Proof of Concept (POC) study on ETI-511, its proprietary, extended release phospholipid gel depot formulation of the NSAID drug meloxicam (Mobec) as a treatment for pain and inflamma?Post to:Delicious&nbsp;&nbsp;Digg&nbsp;&nbsp;reddit&nbsp;&nbsp;Facebook&nbsp;&nbsp;StumbleUpon&nbsp;&nbsp; (Source: Pharmaceutical Technology)

Lack of inhibitory effect of acetylsalicylic acid and meloxicam on whole blood platelet aggregation in cats

ConclusionsAt the doses studied, neither meloxicam nor ASA had an inhibitory effect on WBA or OMBT in cats. Thromboxane concentrations were significantly decreased with ASA treatment. (Source: Journal of Veterinary Emergency and Critical Care)

Diagnostic Challenge

An 11-year-old, 325-g African gray parrot (Psittacus erithacus) presented to the Louisiana State University??School of Veterinary Medicine Teaching Hospital (Baton Rouge, LA USA) as a referral case with a 1-week history of presumed blindness and neurologic signs. The owner reported that 1 week before being presented to the referral hospital, the bird was found at the bottom of its cage acting strangely and that it was unable to interact with the owner. The African gray's diet consisted of a mixture of seeds, nuts, fruits, and vegetables. There were several other parrots housed in the same environment as the African gray, and all of these animals were clinically normal. The bird had been treated at the referring veterinarian's hospital with supportive therapy that included oxygen supplemen...

Adverse drug reactions associated with the use of NSAIDs: a case/noncase analysis of spontaneous reports from the French pharmacovigilance database 2002??2006

AbstractTo evaluate the safety profile of eight oral nonsteroidal anti?inflammatory drugs (NSAIDs) available in France, using data reported through the French pharmacovigilance system. Data (from 2002 to 2006) were analysed for aceclofenac, diclofenac, ketoprofen, meloxicam, naproxen, nimesulide, piroxicam and tenoxicam, focusing on the reported rates of serious adverse drug reactions (ADRs) in the following system organ classes: gastrointestinal, hepatic, cutaneous, renal and cardiovascular. A total of 42??389 serious ADR reports were identified, and 38??506 were included in a case/noncase analysis. Ketoprofen was associated with the highest cumulative reported rate of serious ADRs (0.78 cases per million defined daily doses), followed by diclofenac (0.58), nimesulide (0.52), naproxen...<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>

Single dose oral analgesics for acute postoperative pain in adults.

CONCLUSIONS: There is a wealth of reliable evidence on the analgesic efficacy of single dose oral analgesics. There is also important information on drugs for which there are no data, inadequate data, or where results are unreliable due to susceptibility to publication bias. This should inform choices by professionals and consumers. PMID: 21901726 [PubMed - in process] (Source: Cochrane Database of Systematic Reviews)

Fixed drug eruption due to meloxicam.

Authors: Ozdemir SK, Erkekol FO, Aydin O, Celik GE, Misirligil Z PMID: 21905514 [PubMed - in process] (Source: Journal of Investigational Allergology and Clinical Immunology)

MOBIC (Meloxicam) Tablet MOBIC (Meloxicam) Suspension [Boehringer Ingelheim Pharmaceuticals, Inc.]

Updated Date: Sep 9, 2011 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

Effect of different carriers on in vitro permeation of meloxicam through rat skin

MA Saleem, Sumanji Bala, Liyakat , A AeajazIndian Journal of Pharmaceutical Sciences 2010 72(6):710-718The ability of &#x0026;#946;-cyclodextrin, hydroxypropyl-&#x0026;#946;-cyclodextrin, polyvinyl pyrrolidone and urea to influence the percutaneous absorption of meloxicam through isolated rat skin was evaluated. Carrier complex were prepared by kneading method in 1:1 and 1:2 in molar ratios for &#x0026;#946;-cyclodextrin and hydroxypropyl-&#x0026;#946;-cyclodextrin and in 1:1, 1:3 and 1:5 in weight ratios for polyvinyl pyrrolidone and urea. The complexes were characterized by IR, DSC and evaluated for solubility, dissolution and skin permeability. The solubility, dissolution and permeability of meloxicam were enhanced by using the carriers. The influence of cyclodextrins, polyvinyl pyrroli...<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>

S212 the effectiveness of different schemes of treatment with meloxicam and diclofenac sodium in elderly patients with knee osteoarthritis

(Source: European Journal of Pain Supplements)

Pharmacokinetics of oral meloxicam in ruminant and preruminant calves

Mosher, R. A., Coetzee, J. F., Cull, C. A., Gehring, R., KuKanich, B. Pharmacokinetics of oral meloxicam in ruminant and preruminant calves. J. vet. Pharmacol. Therap. doi: 10.1111/j.1365?2885.2011.01331.x.The pharmacokinetics of oral meloxicam has been studied in ruminant, but not preruminant calves. Oral meloxicam was administered at 0.5??mg/kg to six ruminant calves via gavage (RG); to six preruminant calves via gavage (PRG); and to six preruminant calves via suckling in milk replacer (PRF). Plasma drug concentrations, determined over 120?h postadministration, were analyzed by compartmental and noncompartmental methods. The rate of drug absorption was faster (P??&lt;??0.01) in PRF (0.237??±??0.0478/h) than RG calves (0.0815??±??0.0188/h), while absorption in PRG calves (0.1...

TREPOXICAM-7.5 (Meloxicam, Histidine) Kit [Physician Therapeutics LLC]

Updated Date: Aug 12, 2011 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

The efficacy of tramadol/acetaminophen combination tablets (Ultracet®) as add-on and maintenance therapy in knee osteoarthritis pain inadequately controlled by nonsteroidal anti-inflammatory drug (NSAID)

Abstract&nbsp;&nbsp;The purpose of this study is to compare the efficacy of tramadol 37.5&nbsp;mg/acetaminophen 325&nbsp;mg combination tablets (tramadol/APAP) with that of nonsteroidal anti-inflammatory drugs (NSAIDs) as maintenance therapy following tramadol/APAP and NSAID combination therapy in knee osteoarthritis (OA) pain which was inadequately controlled by NSAIDs. Subjects with knee OA for over 1&nbsp;year and moderate pain (numerical rating scale [NRS] ?5) despite at least 4&nbsp;weeks?? NSAID therapy (meloxicam 7.5&nbsp;mg or 15&nbsp;mg qd or aceclofenac 100&nbsp;mg bid) received tramadol/APAP add-on (combination with NSAID) for 4&nbsp;weeks. Thereafter, subjects with significant pain improvement (NRS &lt;4) were randomized to receive either tramadol/APAP or NSAID for 8&nb...

Investigation of the anti-inflammatory, antinociceptive effect of ellagic acid as measured by digital paw pressure via the Randall-Selitto meter in male Sprague-Dawley rats.

Authors: Gainok J, Daniels R, Golembiowski D, Kindred P, Post L, Strickland R, Garrett N Abstract Ellagic acid (EA), a dietary supplement, is purported to have anti-inflammatory, antinociceptive properties via cyclooxygenase (COX) inhibition. We measured the antinociceptive efficacy of EA alone and in combination with a nonselective COX inhibitor and a selective COX-2 inhibitor. We assigned 54 male Sprague-Dawley rats to 1 of 6 groups to be given the following compounds: (1) vehicle, (2) ketorolac (nonselective COX inhibitor), (3) meloxicam (selective COX-2 inhibitor), (4) EA, (5) EA plus ketorolac, and (6) EA plus meloxicam. Inflammatory pain was induced in the right hind paw by injecting carrageenan. Rats were given study compounds via intraperitoneal injection 30 minutes after p...<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>

Pharmacokinetics of oral meloxicam in ruminant and preruminant calves

Mosher, R. A., Coetzee, J. F., Cull, C. A., Gehring, R., KuKanich, B. Pharmacokinetics of oral meloxicam in ruminant and preruminant calves. J. vet. Pharmacol. Therap. doi: 10.1111/j.1365?2885.2011.01331.x.The pharmacokinetics of oral meloxicam has been studied in ruminant, but not preruminant calves. Oral meloxicam was administered at 0.5??mg/kg to six ruminant calves via gavage (RG); to six preruminant calves via gavage (PRG); and to six preruminant calves via suckling in milk replacer (PRF). Plasma drug concentrations, determined over 120?h postadministration, were analyzed by compartmental and noncompartmental methods. The rate of drug absorption was faster (P??&lt;??0.01) in PRF (0.237??±??0.0478/h) than RG calves (0.0815??±??0.0188/h), while absorption in PRG calves (0.1...

A comparison of the sedative and analgesic properties of pethidine (meperidine) and butorphanol in dogs

Objectives: To compare the analgesic and sedative effects of butorphanol and pethidine (meperidine) in dogs.Methods: Twenty?eight female dogs undergoing ovariectomy (20) or ovariohysterectomy (8) were randomly divided into two groups. Pre?anaesthetic medication in group B consisted of 20 μg/kg intramuscular (im) acepromazine and 0·4 mg/kg butorphanol, while group P received 20 μg/kg acepromazine with 5 mg/kg pethidine. The resulting sedation (simple descriptive scale), propofol dose required to induce anaesthesia, several intraoperative cardiorespiratory variables and postoperative pain (Colorado Pain Scoring System) were compared between the two groups. A 0·2 mg/kg meloxicam dose was administered intravenously to all animals at the end of the 4 hours observation period, or earlier...

Synergism between tramadol and meloxicam in the formalin test involves both opioidergic and serotonergic pathways

This study was designed to evaluate the antinociceptive interaction of the tramadol??meloxicam combination in different proportions (tramadol + meloxicam in 1:1, 1:3, and 3:1 ratios), as well as the role of nitric oxide, opioidergic, and serotonergic pathways in the antinociceptive effect of the combination. The effects of individual drugs and fixed?ratio combinations were assayed using the 3% formalin test in mice. Isobolographic analysis was employed to characterize the synergism produced by the combinations. Tramadol (3.16??10??mg/kg, i.m.), meloxicam (3.16??17.8??mg/kg, i.m.), and tramadol??meloxicam combinations produced a dose?dependent antinociceptive effect. ED30 values were estimated for the individual drugs, and isobolograms were constructed. The tramadol + meloxicam 1:...

Pre-Emptive Analgesic Effectiveness of Meloxicam Versus Tramadol After Mandibular Third Molar Surgery: A Pilot Study

Conclusion: The patients receiving 15 mg of preoperative meloxicam had less pain intensity and total analgesic consumption than those receiving 50 mg of preoperative tramadol. (Source: Journal of Oral and Maxillofacial Surgery)<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>

Development of a lameness model in sheep for assessing efficacy of analgesics

Conclusions?? The local and systemic signs of inflammation and pain, temporary reduction in function of the affected limb and partial amelioration of some of these changes by the dose of meloxicam used here suggest that injection of turpentine in the lower forelimb provides a suitable model for examining the efficacy of analgesics for alleviation of pain and inflammation in sheep. (Source: Australian Veterinary Journal)

Comparable efficacy of standardized Ayurveda formulation and hydroxychloroquine sulfate (HCQS) in the treatment of rheumatoid arthritis (RA): a randomized investigator-blind controlled study

We report a head-to-head comparison in an exploratory drug trial. The objective is to compare standardized Ayurvedic formulations and HCQS in the treatment of RA. One hundred twenty-one patients with active moderately severe RA (ACR 1988 classified) were randomized into a 24-week investigator-blind, parallel efficacy, three-arm (two Ayurvedic and HCQS) multicenter drug trial study; polyherb (Tinospora cordifolia and Zingiber officinale based) and monoherb (Semecarpus anacardium). Study measures included joint counts (pain/tenderness and swelling), pain visual analogue scale, global disease assessments, and health assessment questionnaire. Oral meloxicam (fixed-dosage schedule) was prescribed to all patients during the initial 16&nbsp;weeks. Patients on prednisolone could continue a fi...

Meloxicam, a COX-2 Inhibitor, Ameliorates Ischemia/Reperfusion Injury in Non-Heart-Beating Donor Livers

Eur Surg Res 2011;47:109??117 (DOI:10.1159/000329414) (Source: European Surgical Research)

Pharmacokinetics and pharmacodynamic effects of meloxicam in piglets subjected to a kaolin inflammation model

Fosse, T. K., Spadavecchia, C., Horsberg, T. E., Haga, H. A., Ranheim, B. Pharmacokinetics and pharmacodynamic effects of meloxicam in piglets subjected to a kaolin inflammation model. J. vet. Pharmacol. Therap.34, 367??375.The pharmacokinetics and the analgesic, anti?inflammatory and antipyretic effects of meloxicam were investigated in a placebo controlled study in 2?week?old piglets. Inflammation was induced by a subcutaneous injection of kaolin in the left metacarpus, and 16??h later, meloxicam (0.6??mg/kg) or saline was administered intramuscularly. The absorption half?life was relatively short (0.19??h) and the elimination half?life was 2.6??h. Mechanical nociceptive threshold testing was used to evaluate the analgesic effect, but no significant effect of the meloxicam...

Risk of irregular heart rhythm from ibuprofen ??small??

Conclusion This study assessed whether using NSAIDs or COX-2 inhibitors was associated with subsequent development of atrial fibrillation. The study found that, compared to non-users, recent users were more likely to have incident atrial fibrillation. Consequently, the study estimated that for every 1,000 people who started taking NSAIDs there would be four to seven extra cases of atrial fibrillation. This study had various strengths, including the population-based design and the use of comprehensive hospital and prescription records available in Denmark. However, there was certain information that the researchers could not obtain from these registries, including: Prescription data was used as a proxy for actual use of NSAIDs, so they could not determine the amount of NSAIDs the partici...<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>

[analysis of 76 patients with urticaria and angioedema induced by non-steroidal anti-inflammatory drugs (nsaids) in japan.]

Conclusion: Diversity of NSAIDs-induced urticaria and angioedema was shown in this study. Pathogenesis of NSAIDs-induced urticaria and angioedema without asthma seems to be different from that of NSAIDs-induced asthma. PMID: 21709437 [PubMed - as supplied by publisher] (Source: Arerugi)

PPF microsphere depot sustains NSAID blood levels with infusion?like kinetics without ??burst??

Shang, Q., Wang, X., Apley, M., Kukanich, S. B., Berkland, C. PPF microsphere depot sustains NSAID blood levels with infusion?like kinetics without ??burst??. J. vet. Pharmacol. Therap. doi: 10.1111/j.1365?2885.2011.01317.x.Management of pain is of paramount importance for a myriad of indications in human and animal health. Unfortunately, the administration of pain therapeutics is often complicated by insufficient control over pharmacokinetic profiles as a result of frequent oral dosing. Attempts to sustain and tightly control the concentration of these drugs in the blood via controlled release injectable formulations have typically resulted in drug ??burst??, followed by marginal control over the ensuing pharmacokinetics. Here, precision particle fabrication (PPF) technology was u...

Eudragit EPO Nanoparticles: Application in Improving Therapeutic Efficacy and Reducing Ulcerogenicity of Meloxicam on Oral Administration

(Source: Journal of Biomedical Nanotechnology)

Dose range finding study for the efficacy of meloxicam administered prior to sodium urate?induced synovitis in cats

Conclusions and clinical relevance?? The lowest efficacious dose of meloxicam for relieving pain in cats with an SU?induced synovitis was 0.05 mg kg??1 day??1 PO according to the pre?defined primary outcome measure. However, lower doses may also be effective as seen in the subjective outcome measures. (Source: Veterinary Anaesthesia and Analgesia)

Meloxicam: Enteropathy of the small bowel: case report

(Source: Reactions)<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>

Committee For Medicinal Products For Veterinary Use (CVMP) Meeting Of 7-9 June 2011

The Committee adopted by consensus a positive opinion for an initial marketing authorisation application for Emdocam (meloxicam), from Emdoka bvba, for the use in acute respiratory infections and in diarrhoea in cattle and as adjunctive therapy in the treatment of mastitis. In pigs it is used to reduce the symptoms of lameness and inflammation in non-infectious locomotor disorders and as adjunctive therapy in the treatment of puerperal septicaemia and toxaemia... (Source: Health News from Medical News Today)

Inhibition of cyclooxygenase-2 promotes the stimulatory action of adenosine A(3) receptor agonist on hematopoiesis in sublethally γ-irradiated mice.

Authors: Hofer M, Pospíšil M, Dušek L, Hoferová Z, Weiterová L Mouse hematopoiesis, suppressed by a sublethal dose of ionizing radiation, was the target for combined therapy with a cyclooxygenase-2 (COX-2) inhibitor meloxicam and an adenosine A(3) receptor agonist IB-MECA. The drugs were administered in an early postirradiation treatment regimen: meloxicam was given in a single dose 1hour after irradiation, IB-MECA in two doses 24 and 48hours after irradiation. Treatment-induced changes in several compartments of hematopoietic progenitor and precursor cells of the bone marrow were evaluated on day 3 after irradiation. Values of hematopoietic progenitor cells for granulocytes/macrophages and erythrocytes (GM-CFC and BFU-E, respectively), as well as those of proliferative granulocyt...

A Single Dose of an Inhibitor of Cyclooxygenase 2, Meloxicam, Administered Shortly after Irradiation Increases Survival of Lethally Irradiated Mice.

This study extends earlier findings of the authors demonstrating that meloxicam, a selective inhibitor of cyclooxygenase 2, supports hematopoietic recovery in sublethally irradiated mice and is radioprotective when given before irradiation. We report here that when meloxicam was administered in a single dose 1 h after a lethal 9-Gy whole-body dose, an increased 30-day survival was achieved. Additional studies showed that administration of meloxicam 24 h after lethal irradiation is ineffective and its repeated administration deleterious. Possible mechanisms of the therapeutic effects of meloxicam administered early after irradiation are discussed. PMID: 21663397 [PubMed - as supplied by publisher] (Source: Radiation Research)

MELOXICAM (Meloxicam) Tablet [LUPIN PHARMACEUTICALS INC]

Updated Date: Jun 8, 2011 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

The pharmacokinetics and metabolism of meloxicam in camels after intravenous administration

Wasfi, I. A., Al Ali, W. A., Agha, B. A., Kamel, A. M., Al Biriki, N. A, Al Neaimi, K. M. The pharmacokinetics and metabolism of meloxicam in camels after intravenous administration. J. vet. Pharmacol. Therap. 35, 155??162.The pharmacokinetics and metabolism of meloxicam was studied in camels (Camelus dromedarus) (n??=??6) following intravenous (i.v.) administration of a dose of 0.6??mg·kg/body weight. The results obtained (mean??±??SD) were as follows: the terminal elimination half?life (t1/2β) was 40.2??±??16.8??h and total body clearance (ClT) was 1.94??±??0.66??mL·kg/h. The volume of distribution at steady state (VSS) was 92.8??±??13.7??mL/kg. One metabolite of meloxicam was tentatively identified as methylhydroxy meloxicam. Meloxicam and metabolite were excret...<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>

PPF microsphere depot sustains NSAID blood levels with infusion?like kinetics without ??burst??

Shang, Q., Wang, X., Apley, M., Kukanich, S. B., Berkland, C. PPF microsphere depot sustains NSAID blood levels with infusion?like kinetics without ??burst??. J. vet. Pharmacol. Therap. doi: 10.1111/j.1365?2885.2011.01317.x.Management of pain is of paramount importance for a myriad of indications in human and animal health. Unfortunately, the administration of pain therapeutics is often complicated by insufficient control over pharmacokinetic profiles as a result of frequent oral dosing. Attempts to sustain and tightly control the concentration of these drugs in the blood via controlled release injectable formulations have typically resulted in drug ??burst??, followed by marginal control over the ensuing pharmacokinetics. Here, precision particle fabrication (PPF) technology was u...

The pharmacokinetics and metabolism of meloxicam in camels after intravenous administration

Wasfi, I. A., Al Ali, W. A., Agha, B. A., Kamel, A. M., Al Biriki, N. A, Al Neaimi, K. M. The pharmacokinetics and metabolism of meloxicam in camels after intravenous administration. J. vet. Pharmacol. Therap. doi: 10.1111/j.1365?2885.2011.01312.x.The pharmacokinetics and metabolism of meloxicam was studied in camels (Camelus dromedarus) (n??=??6) following intravenous (i.v.) administration of a dose of 0.6??mg·kg/body weight. The results obtained (mean??±??SD) were as follows: the terminal elimination half?life (t1/2β) was 40.2??±??16.8??h and total body clearance (ClT) was 1.94??±??0.66??mL·kg/h. The volume of distribution at steady state (VSS) was 92.8??±??13.7??mL/kg. One metabolite of meloxicam was tentatively identified as methylhydroxy meloxicam. Meloxicam a...

Effect of local anaesthesia and/or analgesia on pain responses induced by piglet castration

Conclusions: The study concludes that lidocaine reduced pain during castration and that meloxicam reduced pain after castration. The study also concludes that the herdsmen were able to administer local anaesthesia effectively. (Source: Acta Veterinaria Scandinavica)

Meloxicam: Nephrotic syndrome: case report

(Source: Reactions)

Quinine/meloxicam/rofecoxib: Thrombocytopenia and haematoma in an elderly patient: case report

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Cyclooxygenase 2-dependent and independent activation of Akt through casein kinase 2alpha contributes to human bladder cancer cell survival

Conclusions: COX2-dependent and independent activation of CK2-Akt/uPA signal is mainly involved in urothelial carcinoma cell survival, moreover, not only COX2 but also CK2 could be direct targets of COX2 inhibitors. (Source: BMC Urology - Latest articles)

MELOXICAM ( Meloxicam ) Tablet [Unichem Pharmaceuticals (USA), Inc.]

Updated Date: May 11, 2011 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

Committee For Medicinal Products For Veterinary Use (CVMP) Meeting Of 3-5 May 2011

The Committee adopted by majority a positive opinion for an initial marketing authorisation application for Recuvyra (fentanyl), from Procyon Pharmaceutical Ltd, for the control of post-operative pain associated with major orthopaedic and soft tissue surgery in dogs. The Committee adopted by consensus a positive opinion for an extension of the existing authorisation for Loxicom (meloxicam), from Norbrook Laboratories Limited to include a 20 mg/ml solution for injection for cattle, pigs and horses... (Source: Health News from Medical News Today)

MELOXICAM (Meloxicam) Tablet [REMEDYREPACK INC. ]

Updated Date: May 6, 2011 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

TREPOXICAM-7.5 (Meloxicam, Histidine) Kit [Physician Therapeutics LLC]

Updated Date: May 6, 2011 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>

MOBIC (Meloxicam) Tablet [Physicians Total Care, Inc.]

Updated Date: Apr 13, 2011 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

In vitro effect of carprofen and meloxicam on the conductance and permeability to mannitol and the histologic appearance of the gastric mucosa of dogs.

Conclusions and Clinical Relevance-In the gastric mucosa of dogs, carprofen and meloxicam increased in vitro conductance and permeability to mannitol. At a concentration of 400 μg/mL, carprofen caused sloughing of epithelial cells. Carprofen and meloxicam appear to compromise gastric mucosal integrity and barrier function in dogs. PMID: 21453160 [PubMed - in process] (Source: American Journal of Veterinary Research)

Comparison of the efficacy and adverse effects of sustained-release buprenorphine hydrochloride following subcutaneous administration and buprenorphine hydrochloride following oral transmucosal administration in cats undergoing ovariohysterectomy.

Conclusions and Clinical Relevance-In cats undergoing ovariohysterectomy, SC administration of a preoperative dose of SR buprenorphine appeared to have comparable efficacy and adverse effect profile as that of twice-daily OTM administration of buprenorphine before and after surgery. PMID: 21453146 [PubMed - in process] (Source: American Journal of Veterinary Research)

Meloxicam β-Cyclodextrin Transdermal Gel: Physicochemical Characterization and In Vitro Dissolution and Diffusion Studies.

Authors: Abdul Rasool BK, Gareeb RH, Fahmy SA, Abdul Rasool AA The aim of the study was to develop a Meloxicam (ME) transdermal gel formulations based on complexation with β-cyclodextrin. ME β-Cyclodextrin gel formulations were prepared using four different gel bases with different concentrations and different permeation enhancers. The developed formulations were examined for their in vitro characteristics and their diffusion through a mouse skin. The gel formulations were prepared successfully. Physicochemical characterization of ME β-CD complex in solution state by phase solubility revealed 1:1 M complexation of ME with β-Cyclodextrin. ME release profiles from the inclusion complex were superior over ME alone. Hydroxypropyl methyl cellulose 15% w/w gel base was proven to be a sui...

Meloxicam Carbopol-Based Gels: Characterization and Evaluation.

Authors: Sareen R, Kumar S, Gupta GD Purpose: To formulate and evaluate the hydrogels containing meloxicam for topical application and also compare the effect of penetration enhancers on release of drug. Methods: Meloxicam gels were prepared by dispersion method using carbopol-940 and 934 (1%w/w) as rate controlling polymer and drug penetration enhancers such as tween 80, oleic acid and sesame oil in the concentration of 1% and 2% . The formulated gels were evaluated for drug content, pH, viscosity, spreadability, extrudability, in vitro drug permeation, drug release kinetics, bioadhesion test, accelerated stability of selected gel formulation. The in vitro drug permeation through pig's skin was carried out by using Keshary-Chein diffusion cell and viscosity was determined by brookfiel...<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>

Inflammation and Oxidative Stress in Testicular Torsion: Do They Deserve Intensive Treatment to Save Both Guilty and Innocent Testes?

Conclusions: Meloxicam seems to exert its inhibitory effect on the expression of specific genes of inflammation, as well as the combination therapy. Because the effects of these inflammatory genes are still evident 4 days after detorsion, combination therapy using these agents could be administered until late postoperative period to prevent the initiation of autoimmune activity against sperm cells and protect the innocent contralateral testis from the insult of antisperm antibodies. (Source: Urology)

Biological characterization of a myotoxin phosphoplipase A2 homologue purified from the venom of the snake Bothrops moojeni

A myotoxin phospholipase A2 homologue, BmooMtx, was isolated from the venom of Bothrops moojeni by a combination of ion-exchange chromatography on DEAE-Sephacel column and gel filtration on Sephadex G-75. SDS-PAGE showed the enzyme to be a monomer with a molecular weight of 16,500. BmooMtx induced release of creatine kinase and morphological analyses indicated that it provoked an intense myonecrosis, with visible leukocyte infiltrate and damaged muscle cells 24 hours after injection. Anti-BmooMTx antibodies partially neutralized the myotoxic activity of BmooMtx and crude B. moojeni venom, as judged by determination of plasma creatine kinase levels and histological evaluation of skeletal muscle in mice. Anti-BmooMTx antibodies were effective in reducing the plasma creatine kinase levels of ...

TREPOXICAM-7.5 (Meloxicam, Histidine) Kit [Physician Therapeutics LLC]

Updated Date: Mar 9, 2011 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

METACAM (Meloxicam) Suspension [Boehringer Ingelheim Vetmedica, Inc.]

Updated Date: Mar 8, 2011 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

Diclofenac/meloxicam: Bleeding ulcer in elderly patients: 2 case reports

(Source: Reactions)<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>

METACAM (Meloxicam) Suspension [Boehringer Ingelheim Vetmedica, Inc.]

Updated Date: Mar 1, 2011 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

NSAIDS inhibit in vitro MSC chondrogenesis but not osteogenesis: implications for mechanism of bone formation inhibition in man

AbstractThe non?steroidal anti?inflammatory drugs (NSAIDs) are widely used for analgesia but may inhibit bone formation. We investigated whether the reported NSAID effect on bone is related to inhibition of bone marrow mesenchymal stem cell (MSC) proliferation and osteogenic and chondrogenic differentiation and evaluated both cyclooxygenase (COX)?1 and COX?2 specific drugs. The effects of seven COX?1 and COX?2 inhibitors on MSC proliferation and osteogenic and chondrogenic differentiation were tested using Vybrant, sodium 3??[1?(phenylaminocarbonyl)? 3,4?tetrazolium]?bis (4?methoxy?6?nitro) benzene sulfonic acid hydrate (XTT), functional and quantitative assays of MSC differentiation. The MSC expression of COX?1 and COX?2 and prostaglandin E2 (PGE?2) lev...

Development and evaluation of fast-dissolving tablets of meloxicam-β-cyclodextrin complex prepared by direct compression.

Authors: Obaidat AA, Obaidat RM The aim of this study was to prepare fast-dissolving tablets of meloxicam after its complexation with β-cyclodextrin (β-CD) and to investigate the effect of using different superdisintegrants on the disintegration and release of meloxicam from the tablets. A complex of meloxicam with β-CD was prepared by spray drying and then compressed in the form of tablets utilizing the direct compression technique. Three superdisintegrants were employed at various levels - sodium starch glycolate, croscarmellose sodium, and crospovidone. Co-spray dried micro-crystalline cellulose and mannitol (Avicel HFE-102) were used as diluents in the tablets. Prior to compression, the pre-compression parameters showed satisfactory flow properties. Post-compression parameters s...

Synergism between dexketoprofen and meloxicam in an orofacial formalin test was not modified by opioid antagonists.

Authors: Gonzalez C, Zegpi C, Noriega V, Prieto JC, Miranda HF Non-steroidal anti-inflammatory drugs (NSAIDs) are among the most widely used drugs for the management of acute and chronic pain. The role of the opioid system in the synergism between NSAIDs is not well characterized. Mice were injected with a 5% formalin solution (20 μl) into the upper right lip to perform an orofacial formalin test. The isobolographic method was used to determine the interaction between dexketoprofen, which is the (S)-(+) enantiomer of ketoprofen, and meloxicam co-administration. Additionally, the non-selective, opioid antagonist naltrexone, the selective δ opioid receptor (DOP) antagonist naltrindole and the selective κ opioid receptor (KOP) antagonist norbinaltorphimine were used to assess the opioi...

Immunoregulatory function of bone marrow mesenchymal stem cells in EAE depends on their differentiation state and secretion of PGE2

Abstract: Bone marrow mesenchymal stem cells (BMSC)-induced amelioration of experimental autoimmune encephalomyelitis (EAE) was diminished with neuronal differentiantion of BMSC (nBMSC). BMSC secreted large amounts of PGE2, compared to nBMSC, which correlated with higher efficacy to EAE inhibition. EAE mice treated with PGE2 inhibitor, meloxicam showed decreased serum levels of PGE2 and in parallel decreased inhibitory effect on EAE course. In addition, high levels of PGE2 secretion correlated with high expression of indoleamine-2,3-dioxygenase (IDO). Meloxicam blocked IDO expression in BMSC transferred mice indicating functional relation between PGE2 and IDO induction. The current findings demonstrates PGE2 involvement in BMSC-induced inhibition of EAE and provides a mechanistic link betw...<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>

Evaluation of subcutaneous and oral administration of robenacoxib and meloxicam for the treatment of acute pain and inflammation associated with orthopedic surgery in dogs.

Conclusions and Clinical Relevance-Robenacoxib provided efficacy and tolerability similar to those of meloxicam for the management of perioperative pain and inflammation in dogs undergoing orthopedic surgery. PMID: 21281192 [PubMed - in process] (Source: American Journal of Veterinary Research)

Prostaglandins Regulate Conceptus Elongation and Mediate Effects of Interferon Tau on the Ovine Uterine Endometrium.

Authors: Dorniak P, Bazer FW, Spencer TE In ruminants, both the endometrium and conceptus (embryo and associated extraembryonic membranes) trophectoderm synthesize and secrete prostaglandins (PG) during early pregnancy. In mice and humans, prostaglandins regulate endometrial function and conceptus implantation. In study one, bred ewes received intrauterine infusions of vehicle as a control (CX) or meloxicam (MEL), a prostaglandin synthase (PTGS) inhibitor, from Days 8 to 14 post-mating, and the uterine lumen was flushed on Day 14 to recover conceptuses and assess their morphology. Elongating and filamentous conceptuses (12 cm to &gt;14 cm in length) were recovered from all CX ewes. In contrast, MEL ewes contained mostly ovoid or tubular conceptuses. PTGS activity in the uterine endomet...

Piroxicam and meloxicam ameliorate hepatic oxidative stress and protein carbonylation in Kupffer and sinusoidal endothelial cells promoted by ischemia??reperfusion injury

SummaryThe present study was aimed to assess the effect of protein carbonylation (PC) in hepatic cells and effects of nonsteroidal anti?inflammatory drugs (NSAIDs) on indicators of tissue damage induced by liver ischemia??reperfusion injury (LIRI). Warm ischemia was performed by partial vascular occlusion during 90??min in Wistar rats. In serum, we determined the catalytic activity of Alanine Aminotransferase, Aspartate Aminotransferase, Lacticate Dehydrogenase, and Ornithine Carbamoyltransferase. In liver samples, we studied cellular alterations by means of histologic studies, lipid peroxidation, PC by immunohistochemistry, apoptosis and reactive oxygen species in bile by electron paramagnetic resonance. Based on PC data, sinusoidal endothelial cells (SEC) and Kupffer cells (KC) were ...

METACAM (Meloxicam) Injection, Solution [Boehringer Ingelheim Vetmedica, Inc.]

Updated Date: Jan 21, 2011 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

ASAS recommendations for collecting, analysing and reporting NSAID intake in clinical trials/epidemiological studies in axial spondyloarthritis

The objectives of this initiative were to propose both an NSAID equivalent score and a way of collecting and analysing this information in longitudinal clinical studies/trials. For the NSAID equivalent scoring system, the recommendations are (1) to refer to a scale in which 0 = no intake, 100 = 150 mg diclofenac, 1000 mg naproxen, 200 mg aceclofenac, 400 mg celecoxib, 600 mg etodolac, 90 mg etoricoxib, 200 mg flurbiprofen, 2400 mg ibuprofen, 150 mg indometacin, 200 mg ketoprofen, 15 mg meloxicam, 400 mg phenylbutazone, 20 mg piroxicam, 20 mg tenoxicam; (2) to present the results as mean daily intake by considering the number of days on which NSAID has been taken during a period of interest. This initiative should facilitate the conduct and analysis of clinical studies/trials. (Source: Anna...<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>

Postoperative complications in a lamb after major surgery

Conclusion??Clostridium perfringens enterotoxaemia should be considered when clinical signs of severe pain and/or hypovolaemic shock fail to respond to analgesics and fluid resuscitation in lambs after major surgery. (Source: Veterinary Anaesthesia and Analgesia)

Examination of the mechanism(s) of cancer-induced bone pain in animal models

The majority of patients with metastatic prostate or breast cancers will eventually present with skeletal involvement and one of the most common symptoms they will experience is bone pain. Non-steroidal anti-inflammatory drugs (NSAIDs) are standard first line treatment for cancer-induced bone pain (CIBP), followed by more potent central acting agents that act on the opiod recepters such as Morphine. We investigated the possibility of blocking the pain pathway in the periphery. Meloxicam, a preferential cyclooxygenase-2 inhibitor with greater gastrointestinal tolerability than standard NSAIDs, has not been investigated for human CIBP. We tested the efficacy on a murine model of CIBP using Copenhagen rats injected intrafemorally with MATLyLu prostate carcinoma cells. These rats developed loc...

Effects of non-steroidal anti-inflammatory drugs on proliferation, differentiation and migration in equine mesenchymal stem cells.

Authors: Mueller M, Raabe O, Addicks K, Wenisch S, Arnhold S In equine medicine stem cell therapies for orthopaedic diseases are routinely accompanied by application of non-steroidal antiphlogistics (NSAID). Thus, it has to be analysed how NSAIDs actually affect the growth and differentiation potential of MSCs in vitro in order to predict the influence of NSAIDs such as Phenylbutazone, Meloxicam, Celecoxib and Flunixine on MSCs after grafting in vivo. The effects of NSAIDs were evaluated regarding cell viability and proliferation. Additionally, the multilineage differentiation capacity and cell migration was analysed. NSAIDs at lower concentrations (0.1-1 µM for celecoxib and Meloxicam and 10-50 µM for flunixine) exert a positive effect on cell proliferation and migration, while at h...

Effects of CYP2C9*1/*13 on the pharmacokinetics and pharmacodynamics of meloxicam

Conclusions: The CYP2C9*1/*13 genotype is associated with decreased metabolism and increased pharmacodynamic effects of meloxicam. (Source: British Journal of Clinical Pharmacology)

Design of Meloxicam and Lornoxicam Transdermal Patches: Preparation, Physical Characterization, ex Vivo and in Vivo Studies.

Authors: Yener G, Uner M, Gönüllü U, Yildirim S, Kiliç P, Aslan SS, Barla A Transdermal patches of meloxicam (MX) and lornoxicam (LX) were aimed to be prepared in order to overcome their side effects by oral application. The strategy was formulation of optimized films to prepare transdermal patches by determination of physical properties and investigation of drug-excipient compatibility. As the next step, in vitro drug release, assesment of anti-inflammatory effect on Wistar Albino rats, ex vivo skin penetration and investigation of factors on drug release from transdermal patches were studied. Hydroxypropyl methylcellulose (HPMC) was concluded to be suitable polymer for formulation of MX and LX transdermal films indicating pharmaceutical quality required. MX and LX transdermal pat...<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>

MELOXICAM ( Meloxicam ) Tablet [Zydus Pharmaceuticals (USA) Inc.]

Updated Date: Nov 4, 2010 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

Pharmacokinetics of meloxicam following intravenous and oral administration in green iguanas (Iguana iguana).

Conclusions and Clinical Relevance-Results suggested that administration of meloxicam at a dose of 0.2 mg/kg IV or PO in green iguanas would result in plasma concentrations &gt; 0.1 μg/mL for approximately 24 hours. (Am J Vet Res 2010;71:1277-1283). PMID: 21034318 [PubMed - in process] (Source: American Journal of Veterinary Research)

TREPOXICAM (Meloxicam) Tablet [Physician Therapeutics LLC]

Updated Date: Oct 28, 2010 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

Meloxicam-induced enteropathy of the small bowel.

Authors: Are C, Turagam M, Aucar JA, Greenberg E PMID: 20974723 [PubMed - as supplied by publisher] (Source: cmaj)<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>

Diagnostic Challenge

A 2.5-year-old, female, longhair teddy bear hamster (Mesocricetus auratus) presented as an emergency to the Zoological Medicine Service at the Louisiana State University School of Veterinary Medicine (Baton Rouge, LA USA). The hamster had a peracute history of a red fluid observed on the urogenital region. The owner reported no change in her activity or behavior before presentation. On physical examination, the hamster weighed 168 g and appeared bright, alert, and responsive. Palpation of the abdomen revealed a mass, and the hamster exhibited pain when the area was palpated. An ultrasound-guided cystocentesis was performed and the small amount of urine obtained was applied to a urinalysis strip test (Siemens Health Care Diagnostics Inc., Tarrytown, NY USA). The strip test revealed a large ...

Abstracts

This study demonstrated that accumulation of meloxicam after repeated administration occurred as early as the third dose. There were no adverse physical effects noted in the rabbit subjects during or after the study concluded. Based on these results, the authors recommend administration of meloxicam in rabbit patients at a dosage of 0.2 to 0.3 mg/kg orally every 24 hours. (Source: Journal of Exotic Pet Medicine)

Evaluation of Pharmacokinetic-Pharmacodynamic Relationships for BioRelease Meloxicam Formulations in Horses

Abstract: The present study was designed to evaluate the pharmacokinetic-pharmacodynamic relationships for three controlled release meloxicam formulations in horses so as to select one for continued clinical evaluation. Twelve mature research horses of various light breeds were randomly assigned to one of the three treatment groups (n = 4 horses per group). Each horse received two consecutive intramuscular injections at 0 and 72 hours, containing 1,500 mg in 2 mL of one of three experimental BioRelease meloxicam formulations designed to maintain therapeutic blood concentrations (0.15??0.2 μg/mL) for 48 to 96 hours. Blood samples were collected pre and post-treatment. Injection site (0??3) and general well-being (normal or abnormal ?? with description) were recorded at the time of each ...

Efficacy of nimesulide versus meloxicam in the control of pain, swelling and trismus following extraction of impacted lower third molar [Int. J. Oral Maxillofac. Surg. 39 (2010) 580??584]

The above study on nimesulide and meloxicam by De Menezes et al. is read with great interest. The authors have justified the use of nimesulide in their study by stating that the drug was only used in the young and for a short period whilst hepatotoxicity appears usually in older patients and those who have been prescribed a long course of the drug. We would like to highlight that the consumption of nimesulide has been associated with fulminant hepatic failure which would lead to liver transplantation or the demise of the patient. Severe liver failure and encephalopathy had also occurred in the young who have taken limited course of nimesulide. Many countries, including Singapore and Ireland, have withdrawn this drug due to safety concerns. (Source: International Journal of Oral and Maxillo...

Pharmacokinetics and pharmacodynamic effects of meloxicam in piglets subjected to a kaolin inflammation model

Fosse, T. K., Spadavecchia, C., Horsberg, T. E., Haga, H. A., Ranheim, B. Pharmacokinetics and pharmacodynamic effects of meloxicam in piglets subjected to a kaolin inflammation model. J. vet. Pharmacol. Therap. doi: 10.1111/j.1365?2885.2010.01237.x.The pharmacokinetics and the analgesic, anti?inflammatory and antipyretic effects of meloxicam were investigated in a placebo controlled study in 2?week?old piglets. Inflammation was induced by a subcutaneous injection of kaolin in the left metacarpus, and 16??h later, meloxicam (0.6??mg/kg) or saline was administered intramuscularly. The absorption half?life was relatively short (0.19??h) and the elimination half?life was 2.6??h. Mechanical nociceptive threshold testing was used to evaluate the analgesic effect, but no signific...<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>

Effects of firocoxib, meloxicam, and tepoxalin administration on eicosanoid production in target tissues of healthy cats.

Conclusions and Clinical Relevance-Firocoxib and meloxicam administration had no effect on cyclooxygenase-1 activity, whereas tepoxalin administration resulted in inhibition of cyclooxygenase-1 and 5-lipoxygenase. (Am J Vet Res 2010;71:1067-1073). PMID: 20807147 [PubMed - in process] (Source: American Journal of Veterinary Research)

Pharmacokinetics and pharmacodynamic effects of meloxicam in piglets subjected to a kaolin inflammation model

Fosse, T. K., Spadavecchia, C., Horsberg, T. E., Haga, H. A., Ranheim, B. Pharmacokinetics and pharmacodynamic effects of meloxicam in piglets subjected to a kaolin inflammation model. J. vet. Pharmacol. Therap. (Source: Journal of Veterinary Pharmacology and Therapeutics)

Postoperative analgesic efficacy of meloxicam compared to tolfenamic acid in cats undergoing orthopaedic surgery

Objectives (Source: The Journal of Small Animal Practice)

Supramolecular Architectures of Meloxicam Carboxylic Acid Cocrystals, a Crystal Engineering Case Study

Crystal Growth & Design, Volume 0, Issue 0, Articles ASAP (As Soon As Publishable). (Source: Crystal Growth and Design)

Age-dependent modifications in the mRNA levels of the rat excitatory amino acid transporters (EAATs) at 48 hour reperfusion following global ischemia.

This study reports the mRNA levels of some excitatory amino acid transporters (EAATs) in response to ischemia-reperfusion (I/R) in rat hippocampus and cerebral cortex. The study was performed in 3-month-old and 18-month-old animals to analyze the possible role of age in the I/R response of these transporters. The I/R resulted in a reduced transcription of both the neuronal EAAC1 (excitatory amino acid carrier-1) and the neuronal and glial GLT-1 (glial glutamate transporter 1), while the glial GLAST1a (L-glutamate/L-aspartate transporter) transcription increased following I/R. The changes observed were more striking in 3-month-old animals than in 18-month-old animals. We hypothesize that increases in the GLAST1a mRNA levels following I/R insult can be explained by increases in glial cells, ...

Excretion mass balance evaluation, metabolite profile analysis and metabolite identification in plasma and excreta after oral administration of [14C]?meloxicam to the male cat: preliminary study

Grudé, P., Guittard, J., Garcia, C., Daoulas, I., Thoulon, F., Ebner, T. Excretion mass balance evaluation, metabolite profile analysis and metabolite identification in plasma and excreta after oral administration of [14 (Source: Journal of Veterinary Pharmacology and Therapeutics)

ORIGINAL ARTICLE: Safety of meloxicam in patients with aspirin/non?steroidal anti?inflammatory drug?induced urticaria and angioedema

(Source: The Journal of Dermatology)

Evaluation of the Anti-inflammatory Effects of Ellagic Acid.

In this study, 54 Sprague-Dawley rats were assigned to one of six groups: (1) vehicle; (2) ketorolac and vehicle; (3) meloxicam and vehicle; (4) ellagic acid and vehicle; (5) ellagic acid, ketorolac, and vehicle; and (6) ellagic acid, meloxicam, and vehicle. Groups 5 and 6 investigated interactions between ellagic acid and cyclooxygenase inhibitors. Paw inflammation was induced with 3% carrageenan and was measured with a plethysmometer at 30 minutes and 4, 8, and 24 hours after intraperitoneal injection. All rats received one intraperitoneal injection of equivalent volumes according to group assignment. Analysis of covariance followed by post hoc analysis determined that ketorolac was the only compound to significantly reduce paw edema at 4 hours (P = .019); ellagic acid alone (P = .038) a...

Evaluation of the Anti-inflammatory Effects of Ellagic Acid

In this study, 54 Sprague-Dawley rats were assigned to one of six groups: (1) vehicle; (2) ketorolac and vehicle; (3) meloxicam and vehicle; (4) ellagic acid and vehicle; (5) ellagic acid, ketorolac, and vehicle; and (6) ellagic acid, meloxicam, and vehicle. Groups 5 and 6 investigated interactions between ellagic acid and cyclooxygenase inhibitors. Paw inflammation was induced with 3% carrageenan and was measured with a plethysmometer at 30 minutes and 4, 8, and 24 hours after intraperitoneal injection. All rats received one intraperitoneal injection of equivalent volumes according to group assignment. Analysis of covariance followed by post hoc analysis determined that ketorolac was the only compound to significantly reduce paw edema at 4 hours (P = .019); ellagic acid alone (P = .038) ...<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>

Influence on analgesic activity and serum levels after meloxicam complexation with beta-cyclodextrin in mice and rats.

Authors: Lanovsk?½ M, Dolezal T, Proch?¡izkov?¡ M, Sl?­va J, Krsiak M The aim of the present study was to evaluate and compare the analgesic activity and serum levels of meloxicam (CAS 71125-38-7) after administration of meloxicam associated with beta-cyclodextrin (BCD, CAS 7585-39-9) and unmodified meloxicam. The analgesic activity was measured using the plantar test (rats) and the writhing test (mice). In the plantar test, BCD-meloxicam (3 mg/kg and 10 mg/kg orally) showed higher analgesic activity than corresponding doses of meloxicam alone; in the writhing test BCD-meloxicam (7 mg/kg and 15 mg/kg orally) showed stronger analgesic activity than unmodified meloxicam. Serum levels of meloxicam were significantly higher, at 0.5 h and 1 h after administration of BCD-meloxicam or...

Scavenger receptor-B1 and luteal function in mice [Research Articles]

During luteinization, circulating high-density lipoproteins supply cholesterol to ovarian cells via the scavenger receptor-B1 (SCARB1). In the mouse, SCARB1 is expressed in cytoplasm and periphery of theca, granulosa, and cumulus cells of developing follicles and increases dramatically during formation of corpora lutea. Blockade of ovulation in mice with meloxicam, a prostaglandin synthase-2 inhibitor, resulted in follicles with oocytes entrapped in unexpanded cumulus complexes and with granulosa cells with luteinized morphology and expressing SCARB1 characteristic of luteinization. Mice bearing null mutation of the Scarb1 gene (SCARB1&ndash;/&ndash;) had ovaries with small corpora lutea, large follicles with hypertrophied theca cells, and follicular cysts with blood-filled cavities. Plasm...

Pharmacokinetics of meloxicam in adult goats and its analgesic effect in disbudded kids

Ingvast-Larsson, C., Högberg, M., Mengistu, U., Olsén, L., Bondesson, U., Olsson, K. Pharmacokinetics of meloxicam in adult goats and its analgesic effect in disbudded kids. J. vet. Pharmacol. Therap. doi: 10.1111/j.1365-2885.2010.01195.x. The pharmacokinetics and analgesic effect of the nonsteroidal anti-inflammatory drug meloxicam (0.5 mg/kg) in goats were investigated. In a randomized, cross-over design the pharmacokinetic parameters were investigated in adult goats (n = 8) after single intravenous and oral administration. The analgesic effect was evaluated in kids using a randomized, placebo controlled and blinded protocol. Kids received meloxicam (n = 6) once daily and their siblings (n = 5) got isotonic NaCl intramuscularly while still anaesthetized after cautery disbudding and inj...

Development and Validation of a Dissolution Test for Meloxicam and Pridinol Mesylate from Combined Tablet Formulation

SE Vignaduzzo, PM Castellano, TS KaufmanIndian Journal of Pharmaceutical Sciences 2010 72(2):197-203The association of meloxicam and pridinol is indicated for treating muscular contractures and low back pain. A dissolution test for the meloxicam-pridinol combined tablet formulation was developed and validated, using a suitable HPLC method for simultaneously quantitating both dissolved drugs. The optimized conditions include the use of USP apparatus 2 at a paddle rotation rate of 75 rpm and 900 ml of 50 mM phosphate buffer (pH= 7.5) as dissolution medium, at 37.0&#x0026;#177;0.5o. The test, which demonstrated to be robust against small changes in bath temperature, paddle rotation speed and pH of the dissolution medium, was applied to two different brands of tablets; the corresponding dissol...

Prospective Survey of Patient-Controlled Epidural Analgesia With Bupivacaine and Hydromorphone in 3736 Postoperative Orthopedic Patients

Conclusions: Patient-controlled epidural analgesia with bupivacaine and hydromorphone provides effective and safe postoperative analgesia for orthopedic surgery. (C)2010 American Society of Regional Anesthesia and Pain Medicine (Source: Regional Anesthesia and Pain Medicine)<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>

Pre?emptive meloxicam for postoperative analgesia in piglets undergoing surgical castration

Abstract (Source: Veterinary Anaesthesia and Analgesia)

Pre-emptive meloxicam for postoperative analgesia in piglets undergoing surgical castration

Objective To investigate the effect of preoperative meloxicam administration on postoperative stress and pain induced by surgical castration in piglets.Study design Prospective, blinded, randomized clinical trial.Animals One hundred and eighty male piglets of (Source: Veterinary Anaesthesia and Analgesia)

Efficacy of celecoxib, meloxicam and paracetamol in elderly Kashin-Beck Disease (KBD) patients

The objective of this study was to compare the efficacy and tolerability of celecoxib, meloxicam and paracetamol in late Kashin-Beck disease. Adults (n??=??168) with Kashin-Beck disease were randomised in clusters to receive six week courses of celecoxib 200&nbsp;mg once daily, meloxicam 7.5&nbsp;mg once daily or paracetamol 300&nbsp;mg three times daily. Efficacy assessments included overall joint pain intensity and Western Ontario and McMaster Universities Osteoarthritis Index subscales; tolerability was evaluated by adverse event and physician reporting. Celecoxib and meloxicam were efficacious in relieving pain and improving stiffness, but unable to improve physical function after six&nbsp;weeks. Paracetamol was efficacious in relieving pain, but unable to improve morning stiffn...

In vitro and ex vivo inhibition of COX isoforms by robenacoxib in the cat: a comparative study

Schmid, V.B., Seewald, W., Lees, P., King, J.N. In vitro and ex vivo inhibition of COX isoforms by robenacoxib in the cat: a comparative study. J. vet. Pharmacol. Therap. doi: 10.1111/j.1365-2885.2009.01166.x Robenacoxib is a novel nonsteroidal anti-inflammatory drug (NSAID) developed for use in companion animals. Whole blood assays were used to characterize in the cat the pharmacodynamics of robenacoxib for inhibition of the cyclooxygenase (COX) isoforms, COX-1 and COX-2, in comparison with other NSAIDs. Based on in vitro IC50COX-1:IC50COX-2 ratios, robenacoxib was COX-2 selective (ratio = 32.2), diclofenac (ratio = 3.9) and meloxicam (ratio = 2.7) were only weakly COX-2 preferential, and ketoprofen (ratio = 0.049) was COX-1 selective. In an in vivo pharmacokinetic ex vivo pharmacodynamic...

Excretion mass balance evaluation, metabolite profile analysis and metabolite identification in plasma and excreta after oral administration of [14C]-meloxicam to the male cat: preliminary study

The objective of this study was to investigate the metabolic pathways and routes of excretion of oral meloxicam in the cat. [14C]-meloxicam was administered orally to three fasted male cats. Urine, faeces, vomit and cage washes were collected over the following 144 h period. Blood was collected predosing and at 3 and 12 h postdosing. Metabolites were identified by HPLC/MS/MS. When possible a metabolic structure was proposed for each metabolite detected. Only unchanged meloxicam was identified in plasma. Five major metabolites were detected in urine and four in faeces, which were identified by HPLC/MS/MS as products of oxidative metabolism. No conjugated metabolites were detected. Elimination occurred early (61% during the first 48 h). A total of 21% of the recovered dose was eliminated in ...<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>

MOBIC (Meloxicam) Tablet MOBIC (Meloxicam) Suspension [Boehringer Ingelheim Pharmaceuticals, Inc.]

Updated Date: Jun 7, 2010 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

Formulation of meloxicam gel for topical application: In vitro and in vivo evaluation.

Authors: Bachhav YG, Patravale VB Skin delivery of NSAIDs offers several advantages over the oral route associated with potential side effects. In the present investigation, topical gel of meloxicam (MLX) was formulated using N-methyl pyrrolidone (NMP) as a solubilizer and Carbopol Ultrez 10® as a gelling polymer. MLX gel was evaluated with respect to different physicochemical parameters such as pH, viscosity and spreadability. Irritation potential of MLX gel was studied on rabbits. Permeation of MLX gel was studied using freshly excised rat skin as a membrane. Anti-inflammatory activity of MLX gel was studied in rats and compared with the commercial formulation of piroxicam (Pirox® gel, 0.5% m/m). Accelerated stability studies were carried out for MLX gel for 6 months according to I...

Renal Tissue Damage After Experimental Pyelonephritis: Role of Antioxidants and Selective Cyclooxygenase-2 Inhibitors

Conclusions: L-carnitine and meloxicam alleviated oxidative stress, probably by decreasing lipid peroxidation and enforcing antioxidant defense system. Acute renal inflammatory injury can be prevented much more effectively by combination therapy rather than by conventional therapy alone. (Source: Urology)

Mobic (Meloxicam) - updated on RxList

Mobic (Meloxicam) drug description - FDA approved labeling for prescription drugs and medications at RxList (Source: RxList - New and Updated Drug Monographs)

MOBIC (Meloxicam) Tablet MOBIC (Meloxicam) Suspension [Boehringer Ingelheim Pharmaceuticals, Inc.]

Updated Date: May 24, 2010 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>

MELOXICAM (Meloxicam ) Tablet [Apotex Corp]

Updated Date: May 14, 2010 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

Meloxicam protects cell damage from 1-methyl-4-phenyl pyridinium toxicity via the phosphatidylinositol 3-kinase/Akt pathway in human dopaminergic neuroblastoma SH-SY5Y cells.

In this study, we investigated the neuroprotective effect of NSAIDs on neuronal damage induced by 1-methyl-4-phenyl pyridinium (MPP(+)) in human dopaminergic SH-SY5Y neuroblastoma cells. Of the NSAIDs tested, only meloxicam indicated protective effect on MPP(+)-induced neurotoxicity in SH-SY5Y cells, although such an effect was not established with indomethacin, ibuprofen and cyclooxygenase (COX)-2 selective inhibitors (NS-398 and CAY-10404). The neuroprotective effect of meloxicam against MPP(+) toxicity was specific, as toxicities induced by other cytotoxic agents (such as rotenone, MG-132, tunicamycin and ethacrynic acid) were not attenuated by meloxicam. The neuroprotective effect of meloxicam on MPP(+)-induced apoptosis was abolished by a phosphatidylinositol 3-kinase (PI3K) inhibitor...

Lithium/meloxicam interaction: Lithium toxicity and neurological disorders: case report

(Source: Reactions)

Meloxicam effects in Hispaniolan parrots

Adequate pain control is an an important aspect of medical treatment in all animals, including birds. Nonsteroidal anti-inflammatory drugs (NSAIDS) are an aid in controlling inflammation and pain. NSAIDS block the binding of arachidonic acid to cyclooxygenase (COX), preventing the conversion of thromboxane A2 to thromboxane B2 and the production of prostaglandins, which are potent mediators of inflammation. Cyclooxygenases are expressed in the central nervous system of vertebrates, and their relative expression varies depending on the species. COX is found broadly distributed in chickens. (Source: Advances in Small Animal Medicine and Surgery)

Efficacy of nimesulide versus meloxicam in the control of pain, swelling and trismus following extraction of impacted lower third molar

This study compared the efficacy of nimesulide and meloxicam in the control of pain, swelling and trismus, following the extraction of impacted inferior third molars. Twenty patients with two impacted inferior third molars, in similar positions, were selected. The patients were designated randomly to the meloxicam group (MEL: 7.5mg twice a day for 5 days) or the nimesulide group (NIM: 100mg for 5 days). Following the extractions, swelling was more pronounced in the MEL group than in the NIM group (P?0.001). There were no significant differences in pain intensity between the treatment groups (P>0.05). At the 72-h evaluation, reduction was significantly larger in mouth opening in the MEL group compared with the NIM group (P (Source: International Journal of Oral and Maxillofacial Surgery)<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>

The Effects of Meloxicam on Neural Tube Development in the Early Stage of Chick Embryos.

CONCLUSION: Our results suggested that meloxicam, a nonselective COX inhibitor, caused neural tube closure defects when injected at supratherapeutic doses. However, further studies with larger numbers of subjects are needed for its use in lower doses. PMID: 20401837 [PubMed - as supplied by publisher] (Source: Turkish Neurosurgery)

AMPA receptor downregulation induced by ischaemia/reperfusion is attenuated by age and blocked by meloxicam

Conclusion: Our data suggest that changes in the AMPAR isoforms could be associated with ageing in the different structures studied. Although GluR2 editing seems to be involved in age-dependent vulnerability to ischaemia supporting the 'GluR2 hypothesis', this alone does not explain the differential vulnerability in the different brain regions. Finally, inflammation could play a role in protection from I/R-induced injury. (Source: Neuropathology and Applied Neurobiology)

A Phase III Randomized Trial of the Timing of Meloxicam With Iodine-125 Prostate Brachytherapy

Conclusions: Starting meloxicam 1 week prior to brachytherapy compared to starting immediately after the procedure did not reduce 1-month edema, improve IPSSs at 1 or 3 months, or reduce the need for catheterization. (Source: International Journal of Radiation Oncology * Biology * Physics)

Sensory and vascular changes in a rat monoarthritis model: prophylactic and therapeutic effects of meloxicam

Conclusion&nbsp;&nbsp;The present study provides a unique comparison of prophylactic versus therapeutic effects of meloxicam in the CFA-induced model of monoarthritis. Content Type Journal ArticleCategory Original Research PaperDOI 10.1007/s00011-010-0179-3Authors Javeria Ali Hashmi, University of Western Ontario Department of Physiology and Pharmacology London ON CanadaKiran Yashpal, University of Western Ontario Department of Physiology and Pharmacology London ON CanadaDavid W. Holdsworth, University of Western Ontario Robarts Research Institute London ON CanadaJames L. Henry, University of Western Ontario Department of Physiology and Pharmacology London ON Canada Journal Inflammation ResearchOnline ISSN 1420-908XPrint ISSN 1023-3830 (Source: Inflammation Research)

Dehydration-induced increase in aquaporin-2 protein abundance is blocked by nonsteroidal anti-inflammatory drugs

In this study, we planned to investigate whether prostaglandins, known to modulate AQP2 trafficking, may play a role in this process. Male Wistar rats were kept in metabolic cages, with either free access to water and food, or were given 15 g of food gelled with water, such that they were fluid restricted or fluid loaded. The effects of oral administration of two structurally different NSAIDs, indomethacin and ibuprofen, and a COX-2-selective NSAID, meloxicam, on urine output and AQP2 expression were investigated in kidneys removed under terminal anesthesia. All the NSAIDs decreased AQP2 expression significantly in water-restricted rats but did not significantly alter PGE excretion. In water-loaded rats, the effects were less marked, and meloxicam had no significant effect. Consistent with...<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>

Effects of aspirin, carprofen, deracoxib, and meloxicam on platelet function and systemic prostaglandin concentrations in healthy dogs.

Conclusions and Clinical Relevance-Oral administration of commonly used NSAIDs at therapeutic dosages in healthy dogs did not alter plasma TXB(2) and 6-keto PGF(1alpha) concentrations. Deracoxib administration resulted in a minor abnormality in platelet aggregation. Anti-inflammatory doses of aspirin did not affect platelet function as measured by use of optical aggregometry and a platelet-function analyzer. Further evaluation of the effects of aspirin and cyclooxygenase-2-selective inhibitors on hemostasis should be performed. PMID: 20187838 [PubMed - in process] (Source: American Journal of Veterinary Research)

Risk Factors of Drug Interaction between Warfarin and Nonsteroidal Anti-Inflammatory Drugs in Practical Setting.

In conclusion, special caution is required when an NSAID is administered to warfarin users if patients are taking warfarin &gt;40 mg/week and other medications interacting with warfarin. PMID: 20191029 [PubMed - in process] (Source: J Korean Med Sci)

Variability among nonsteroidal antiinflammatory drugs in risk of upper gastrointestinal bleeding

This study was undertaken to assess the risk of upper GI bleeding/perforation among users of individual NSAIDs and to analyze the correlation between this risk and the degree of inhibition of whole blood cyclooxygenase 1 (COX-1) and COX-2 in vitro.We conducted a systematic review of observational studies on NSAIDs and upper GI bleeding/perforation published between 2000 and 2008. We calculated pooled relative risk (RR) estimates of upper GI bleeding/perforation for individual NSAIDs. Additionally, we verified whether the degree of inhibition of whole blood COX-1 and COX-2 in vitro by average circulating concentrations predicted the RR of upper GI bleeding/perforation.The RR of upper GI bleeding/perforation was 4.50 (95% confidence interval [95% CI] 3.82-5.31) for traditional NSAIDs and 1.8...

Successful Treatment With Meloxicam, a Cyclooxygenase-2 Inhibitor, of Patients With Extra-Abdominal Desmoid Tumors: A Pilot Study [CORRESPONDENCE]

(Source: Journal of Clinical Oncology)

MELOXICAM (Meloxicam) Tablet MELOXICAM (Meloxicam) Tablet [Rebel Distributors Corp.]

Updated Date: Feb 17, 2010 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>

The COX-2 inhibitors, meloxicam and nimesulide, suppress neurogenesis in the adult mouse brain

Conclusions and implications: Treatment with a COX-2 inhibitor results in a substantial inhibition of adult neurogenesis. Studies on human tissues are warranted in order to determine if this effect extends to humans, and whether inhibition of neurogenesis should be considered as an adverse effect of these drugs. (Source: British Journal of Pharmacology)

Dehydration-induced increase in aquaporin-2 protein abundance is blocked by non-steroidal anti-inflammatory drugs.

In this study we planned to investigate whether prostaglandins, known to modulate AQP2 trafficking, may play a role in this process. Male Wistar rats were kept in metabolic cages, with either free access to water and food, or were given 15g of food gelled with water, such that they were fluid-restricted or fluid-loaded. The effects of oral administration of two structurally different NSAIDs, indomethacin and ibuprofen, and a COX-2-selective NSAID, meloxicam, on urine output and AQP2 expression were investigated in kidneys removed under terminal anaesthesia. All the NSAIDs decreased AQP2 expression significantly in water-restricted rats, but did not significantly alter PGE excretion. In water loaded rats the effects were less marked, and meloxicam had no significant effect. Consistent with ...

Severe adverse skin reactions to nonsteroidal antiinflammatory drugs: A review of the literature.

CONCLUSION: The risk of SJS or TEN in patients receiving NSAIDs is extremely low; older patients, women, and patients within the first month of treatment initiation appear to have the greatest risk. Health care providers and patients should be aware of the signs and symptoms of SJS and TEN. PMID: 20101062 [PubMed - in process] (Source: American Journal of Health-System Pharmacy : AJHP)

Review: Low risk of severe dermatological reactions to NSAIDs

Source: American Journal of Health-System Pharmacy Area: News A review of the medical literature has found that the risk of Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) associated with the use of nonsteroidal antiinflammatory drugs (NSAIDs) is extremely low. The greatest risk can be seen in older patients, women, and patients within the first month of treatment initiation. &nbsp; The authors of this review searched for studies, case series and case reports of SJS and TEN associated with NSAIDs and cyclooxygenase-2-selective NSAIDs available in the United States. From the available data they made the following observations (data from abstract as full report not available): .&nbsp;"oxicam" derivatives appeared to have the greatest association with SJS and TEN. T...

Design, Characterization, and Evaluation of Meloxicam Gel Prepared by Suspension and Solution Polymerization Using Solubility Parameter as the Basis for Development.

Authors: Jain D, Pathak K Meloxicam gel was designed based on the matching of the solubility parameter (delta) of the drug with that of the polymer and subsequently with skin for improved dermal delivery of meloxicam. The delta of meloxicam (11.48 (cal/cm(3))(0.5)) determined by solubility measurement was matched statistically to the solubility parameter of monomers, n-vinyl-2-pyrrolidone, polyvinyl alcohol (PVA), hydroxyl ethyl methacrylate, ethylene glycol methacrylate (EGMA) determined by intrinsic viscosity measurement. Consequently gels were formulated by polymerization in selected solvent blend of water/ethyl acetate (20:80) in which the drug showed maximum solubility. Thus, F1-F16 formulations designed were evaluated for physicochemical properties, textural analysis, and in vitr...<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>

Suppression of follicular rupture with meloxicam, a cyclooxygenase-2 inhibitor: potential for emergency contraception

CONCLUSIONS Meloxicam 30 mg given for five consecutive days in the late follicular phase is safe, effective and may be an alternative form of emergency contraception. (Source: Human Reproduction)

Oral administration of the cyclooxygenase-2 (COX-2) inhibitor meloxicam blocks ovulation in non-human primates when administered to simulate emergency contraception

CONCLUSIONS A 5-day course of oral meloxicam administered around the time of ovulation reduced the rate of oocyte release without alteration of reproductive hormones or menstrual cycle length. Meloxicam may be effective as an emergency contraceptive in women. (Source: Human Reproduction)

NSAIDS inhibit in vitro MSC chondrogenesis but not osteogenesis.

Conclusions. These findings suggest that NSAIDs may inhibit bone formation via blockage of MSC chondrogenic differentiation which is an important intermediate phase in normal endochondral bone formation. PMID: 20070439 [PubMed - as supplied by publisher] (Source: J Cell Mol Med)

Meloxicam Promising for Emergency Contraception

Oral meloxicam blocks ovulation in monkeys without altering reproductive hormones, researchers report in a December 4th on-line paper in Human Reproduction, suggesting that it may be of use as an emergency contraceptive. Reuters Health Information (Source: Medscape Today Headlines)

COX-2 Inhibitor Potential Treatment for Extraabdominal Desmoid Tumors

A preliminary trial shows that meloxicam might be an effective therapy in this population, without the potential adverse effects of chemotherapy. Medscape Medical News (Source: Medscape Today Headlines)<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>

MOBIC (Meloxicam) Tablet MOBIC (Meloxicam) Suspension [Boehringer Ingelheim Pharmaceuticals Inc.]

Updated Date: Dec 24, 2009 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

Docetaxel: Nail disorders treated with meloxicam: case report

(Source: Reactions)

Trends in the non-steroidal anti-inflammatory drug market in six Central-Eastern European countries based on retail information

The objective of this study was to evaluate the non-steroidal anti-inflammatory drug market of six Central and Eastern European countries. Trends and similarities were compared across the examined countries.The Intercontinental Marketing Service Health database was used to determine consumption data between the years 2000 and 2007. We applied the anatomical therapeutical chemical-defined daily dose method, focussing on three major non-steroidal anti-inflammatory drug groups: conventional non-steroidal anti-inflammatory drugs, 'stronger cyclooxygenase 2 inhibitors' (all together as: non-cyclooxygenase 2 selective non-steroidal anti-inflammatory drugs) and selective cyclooxygenase 2 inhibitors. The main outcome measure was defined daily dose/1000 inhabitants/day. Different active agents have...

Toxicity of non-steroidal anti-inflammatory drugs to Gyps vultures: a new threat from ketoprofen.

Authors: Naidoo V, Wolter K, Cromarty D, Diekmann M, Duncan N, Meharg AA, Taggart MA, Venter L, Cuthbert R Three Gyps vulture species are on the brink of extinction in South Asia owing to the veterinary non-steroidal anti-inflammatory drug (NSAID) diclofenac. Carcasses of domesticated ungulates are the main food source for Asia's vultures and birds die from kidney failure after consuming diclofenac-contaminated tissues. Here, we report on the safety testing of the NSAID ketoprofen, which was not reported to cause mortality in clinical treatment of scavenging birds and is rapidly eliminated from livestock tissues. Safety testing was undertaken using captive non-releasable Cape griffon vultures (Gyps coprotheres) and wild-caught African white-backed vultures (G. africanus), both previous...

Meloxicam effects on plasma iohexol clearance

Prostaglandins produced by cyclooxygenase (COX) enzymes are important mediators of vascular tone, salt and water balance, and renin release. In dogs, prostaglandins increase renal blood flow by counteracting vasoconstriction in the renal vasculature caused by angiotensin II and norepinephrine. They therefore maintain normal glomerular filtration rate (GFR) under physiologic conditions associated with decreased intravascular volume. (Source: Advances in Small Animal Medicine and Surgery)<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>

Analgesic effects of intramuscular administration of meloxicam in Hispaniolan parrots (Amazona ventralis) with experimentally induced arthritis.

Conclusions and Clinical Relevance-Meloxicam administered at 1.0 mg/kg, IM, every 12 hours effectively relieved arthritic pain in parrots. PMID: 19951118 [PubMed - in process] (Source: American Journal of Veterinary Research)

COX-2 Inhibitors Are Contraindicated for Treatment of Combined Injury.

This study points to potential contraindications for use of COX-2 inhibitors in patients undergoing therapy for radiation injury and combined injury. PMID: 19929415 [PubMed - as supplied by publisher] (Source: Radiation Research)

Anti-implantation activity of H(2) receptor blockers and meloxicam, a COX-inhibitor, in albino Wistar rats.

Conclusion Our results indirectly confirm the combined involvement of histamine and prostaglandins in the implantation process. The mast cell stabilising property of H(2) blockers appears to be a possible mechanism for their anti-implantation activity. PMID: 19929648 [PubMed - in process] (Source: The European Journal of Contraception and Reproductive Health Care)

MELOXICAM (Meloxicam) Tablet MELOXICAM (Meloxicam) Tablet [Rebel Distributors Corp.]

Updated Date: Nov 24, 2009 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

MELOXICAM (Meloxicam) Tablet MELOXICAM (Meloxicam) Tablet [Rebel Distributors Corp, DBA Physician Partner]

Updated Date: Nov 20, 2009 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>

Multicenter Phase II Trial of Combination Therapy with Meloxicam, a COX-2 Inhibitor, and Natural Interferon-{alpha} for Metastatic Renal Cell Carcinoma

Conclusions The combination of meloxicam and natural IFN- is considered to be an active regimen with tolerable toxicities as a first-line treatment of metastatic renal cell carcinoma. (Source: Japanese Journal of Clinical Oncology)

Kneading Technique for Preparation of Binary Solid Dispersion of Meloxicam with Poloxamer 188.

In conclusion, dissolution enhancement of MLX was obtained by preparing its solid dispersion with PXM using kneading technique. PMID: 19862626 [PubMed - as supplied by publisher] (Source: AAPS PharmSciTech)

Proteomic analysis in NSAIDs-Treated primary cardiomyocytes.

In this study, we tried to identify proteins responding to the cellular toxicity in NSAIDs-treated primarily cultured cardiomyocytes using 2-D proteomic analysis. We used seven different NSAIDs (celecoxib, rofecoxib, valdecoxib, diclofenac, naproxen, ibuprofen, meloxicam) possessing each different degree of cardiovascular risk. Overall protein spots were similar in all NSAIDs-treated cells although numbers of decreased proteins were about 2-fold higher in celecoxib or rofecoxib-treated cells than in cells incubated with other NSAIDs. Many stress-related proteins, cardiac muscle movement proteins and proteins involving in membrane organization have been isolated. Among them, Septin-8, a filament scaffolding protein, showed its specific expression pattern depending on the extent of drug toxi...

Regulation of prostaglandin E2 synthesis in cells derived from chondrocytes of patients with osteoarthritis

Conclusions&nbsp;&nbsp;These results suggested that in cells derived from OA chondrocytes different mechanisms of regulation exist between mPGES-1 and COX-2, and the expression of mPGES-1 was, at least partially, regulated through the autocrine positive feedback by PGE2. Content Type Journal ArticleCategory Original ArticleDOI 10.1007/s00776-009-1370-7Authors Hisashi Shimpo, Tokoname Municipal Hospital Department of Orthopedic Surgery 4-5 Koiehonmachi, Tokoname Aichi 479-8510 JapanTadahiro Sakai, Nagoya University Department of Orthopedic Surgery Nagoya JapanSeiji Kondo, Chukyo Women??s University Department of Physical Education, Junior College Nagoya JapanShinji Mishima, Tokyo Kosei Nenkin Hospital Department of Orthopedic Surgery Tokyo JapanMasaki Yoda, Nagoya University Depa...

Effect of nonsteroidal anti-inflammatory drugs with varied cyclooxygenase-2 selectivity on cyclooxygenase protein and prostanoid concentrations in pyloric and duodenal mucosa of dogs.

Conclusions and Clinical Relevance-Prostanoid concentrations in gastric and duodenal tissues, and gross and histologic appearances, were not significantly affected by drugs with varied COX-2 selectivity. These findings suggested that, for these experimental conditions, there were no differences among the preferential and selective COX-2 inhibitors with regard to adverse effects on the gastric and duodenal portions of the gastrointestinal tract of dogs. PMID: 19795939 [PubMed - in process] (Source: American Journal of Veterinary Research)<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>

Evaluation of analgesic efficacy, gastrotoxicity and nephrotoxicity of fixed-dose combinations of nonselective, preferential and selective cyclooxgenase inhibitors with paracetamol in rats.

Authors: Kumar G, Hota D, Nahar Saikia U, Pandhi P Nonsteroidal anti-inflammatory drugs (NSAIDs) are combined with paracetamol (PCM) with a view to enhance analgesic efficacy and reduce gastric toxicity. However, there are reports of enhanced nephrotoxicity with nonselective NSAID with PCM combinations. The present study investigated the analgesic efficacy, gastrotoxicity and nephrotoxicity of nonselective, preferential and selective cyclooxgenase inhibitors and their combination with PCM in rats. Graded doses of ibuprofen, meloxicam and celecoxib alone and their combination with fixed dose of PCM were administered to the rats by gavage for 14 days. The results showed that PCM potentiated the analgesic effect of all three classes of NSAIDs significantly as evidenced by increase in tail...

Population pharmacokinetic modelling and simulation of single and multiple dose administration of meloxicam in cats

The objectives of these investigations were: first, to describe the pharmacokinetic properties of meloxicam in cats following single and multiple oral administration and secondly, to simulate different oral dosage regimes for meloxicam in cats after multiple dose administration to illustrate and evaluate those dosage regimes for the alleviation of inflammation and pain in cats. Six healthy domestic short hair cats were treated orally with various dosage regimes (0.05[ndash]0.2 mg/kg/day). Plasma samples were collected at predefined times and quantitatively analysed using liquid/liquid extraction followed by reverse phase HPLC with UV-detection. Meloxicam plasma concentration data were analysed using the population pharmacokinetic approach (software: NONMEM). The final model was used to sim...

Multicenter phase II yrial of combination therapy with meloxicam, a COX-2 inhibitor, and ...

Department of Renal and Genitourinary Surgery, Graduate School of Medicine, Hokkaido University (Source: UroToday)

Mobic (meloxicam) 7.5mg Tablets - Revised SPC

Source: eMC (electronic Medicines Compendium) Area: Other Library Updates > SPC Changes Section 4.4 (special warnings and precautions for use)&nbsp;has been updated with the following changes: - Meloxicam is not appropriate for the treatment of patients requiring relief from acute pain. - Cardiovascular and cerebrovascular effects - Clinical monitoring of blood pressure for patients at risk is recommended at baseline and especially during treatment initiation with meloxicam. The information in section 4.5 (interactions) has been updated relating to NSAIDS, corticosteroids and cyclosporin.&nbsp; There has also been additional information added relating to anticoagulants and heparin. (Source: NeLM - Rheumatology)

Studies on microbial transformation of meloxicam by fungi.

Authors: G SP, Girisham S, Reddy SM Screening-scale studies were performed with 26 fungal cultures for their ability to transform the anti-inflammatory drug meloxicam. Among the different fungi screened, a filamentous fungus, Cunninghamella blakesleeana NCIM 687, transformed meloxicam to three metabolites in significant quantities. The transformation of meloxicam was confirmed by high-performance liquid chromatography (HPLC). Based on the liquid chromatography-tandem mass spectrometry (LC-MS/MS) data, two metabolites were predicted to be 5-hydroxymethyl meloxicam and 5-carboxy meloxicam, the major mammalian metabolites reported previously. A new metabolite was produced, which is not detected in mammalian systems. Glucose medium, pH of 6.0, temperature of 27 degrees , 5-day incubation p...<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>

Treatment of feline mammary tumours using chemotherapy, surgery and a COX-2 inhibitor drug (meloxicam): a retrospective study of 23 Cases (2002&#x2013;2007)*

The efficacy of a treatment combination of a COX-2 inhibitor (meloxicam), chemotherapy and surgery in 23 cats with histologically confirmed mammary gland adenocarcinoma was evaluated. All of the cases underwent an aggressive surgery with concurrent doxorubicin-based chemotherapy. Meloxicam was given orally starting the day after surgery and was continued indefinitely. Serum renal parameters were measured every 3[ndash]5 months. Three cats developed azotemia, whereas in four other renal parameters increased but remained within normal limit. The Kaplan[ndash]Meier median survival time was 460 days. The Kaplan[ndash]Meier median disease free interval was 269 days. The survival times are similar to other studies, not supporting the use of this treatment combination. Prospective studies with a ...

A Quantitative Enterohepatic Circulation Model: Development and Evaluation with Tesofensine and Meloxicam

(Source: Clinical Pharmacokinetics)

Combining kallistatin gene therapy and meloxicam to treat hepatocellular carcinoma in mice

Hepatocellular carcinoma (HCC) is one of the most common cancer-related causes of death, and conventional treatments offer unsatisfactory response. We have previously reported that kallistatin gene therapy suppressed the growth of HCC tumors by its anti-angiogenic activity, and meloxicam, a selective COX-2 inhibitor, inhibited proliferation and induced apoptosis of human HCC cells in vitro. The aim of this study was to determine whether combining kallistatin gene therapy and meloxicam could offer a better therapeutic effect to combat HCC in mice. A kallistatin expression plasmid was constructed and its expression was detected after intratumoral gene transfer. Both kallistatin gene therapy and meloxicam suppressed the growth of subcutaneous human HepG2 tumors established in BALB/c nude mice...

Abbott Announces Partnership with Velcera to Bring New Pain Medication for Dogs to Market

ABBOTT PARK, Ill., Aug. 18 (HSMN NewsFeed) -- Abbott (NYSE: ABT ) announced today they have partnered with Velcera, Inc., a specialty pharmaceutical company focused on pet health, to market the first canine pain management product delivered in a transmuc... Biopharmaceuticals, Drug DeliveryAbbott, Velcera, meloxicam, Promist , transmucosal (Source: HSMN NewsFeed)

Boost for endangered vultures after captive breeding success

Two slender-billed vultures born in RSPB breeding programme in India as wild population heads towards extinctionOne of the world's most threatened birds has been successfully bred in captivity for the first time, conservationists said today.The slender-billed vulture, which is even more threatened than the tiger in India, is one of several Asian species of the carrion-eating bird which has seen dramatic declines in numbers in recent years and are now critically endangered. There are just 1,000 slender-billed vultures left in the wild, according to the RSPB.Conservationists say successfully breeding one of the birds in captivity is a "huge boost" to efforts to prevent it becoming extinct in the wild.The slender-billed vulture and another species, the long-billed vulture, have together suffe...<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>

Analgesic and anti-inflammatory actions of robenacoxib in acute joint inflammation in dog

The objectives of this study were to establish dose[ndash]response and blood concentration[ndash]response relationships for robenacoxib, a novel nonsteroidal anti-inflammatory drug with selectivity for inhibition of the cyclooxygenase (COX)-2 isoenzyme, in a canine model of synovitis. Acute synovitis of the stifle joint was induced by intra-articular injection of sodium urate crystals. Robenacoxib (0.25, 0.5, 1.0, 2.0 and 4.0 mg/kg), placebo and meloxicam (0.2 mg/kg) were administered subcutaneously (s.c.) 3 h after the urate crystals. Pharmacodynamic endpoints included data from forceplate analyses, clinical orthopaedic examinations and time course of inhibition of COX-1 and COX-2 in ex vivo whole blood assays. Blood was collected for pharmacokinetics. Robenacoxib produced dose-related im...

Investigation of Neuroprotective Effects of Cyclooxygenase Inhibitors in the 6-Hydroxydopamine Induced Rat Parkinson Model.

CONCLUSION: Oral usage of low repeated doses of nonsteroidal anti-inflammatory drugs may possibly slow down the progression of the disease. PMID: 19621286 [PubMed - as supplied by publisher] (Source: Turkish Neurosurgery)

Sequential injection system for phospholipase A2 activity evaluation: studies on liposomes using an environment-sensitive fluorescent probe.

Authors: Araujo AR, Gaspar D, L&#xFA;cio M, Reis S, Saraiva ML, Lima JL This work reports the development of an automatic methodology based on the use of 1-anilinonaphthalene-8-sulfonate (ANS) as an interfacial fluorescent probe for detecting the hydrophobic environment shift around the probe, caused by the hydrolytic action of PLA(2) on the liposomes. The implementation of this reaction in a sequential injection analysis (SIA) system along with the use of the mixing chambers permitted the evaluation of PLA(2) activity and assessment of the inhibitory effect of the non-steroidal anti-inflammatory drugs (NSAIDs) on PLA(2) activity. Several studies were performed with the aim of establishing the appropriate flow system configuration: the liposome substrate; PLA(2) and ANS optimum concent...

Effects of meloxicam on reproduction parameters in dairy cattle

This study was carried out in dairy cattle with the NSAID meloxicam to investigate possible drug effects on different reproductive parameters as well as on the progeny. Forty-one cows received intravenous injection of either meloxicam (Metacam® 20 mg/mL solution for injection) or placebo at a dose volume of 7.5 mL/100 kg, corresponding to a dose of 1.5 mg meloxicam/kg, i.e. three times the recommended therapeutic dose. Treatment was performed in each phase of reproduction, i.e. once prior to breeding, twice shortly after breeding, once at the beginning of the second and third trimester of gestation and once at the end of the third trimester of gestation. Offspring of the cows were weighed and clinically examined for vitality at birth and after 28 days. No relevant difference between the m...

Selective and non-selective non-steroidal anti-inflammatory drugs and the risk of acute kidney injury

This study provides evidence that risk of AKI may be lower with more selective agents than with naproxen or other non-selective NSAIDs. Copyright © 2009 John Wiley & Sons, Ltd. (Source: Pharmacoepidemiology and Drug Safety)<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>

Effects of meloxicam on plasma iohexol clearance as a marker of glomerular filtration rate in conscious healthy cats.

Conclusions and Clinical Relevance-In this study, short-term meloxicam administration did not measurably alter the glomerular filtration rate as assessed via plasma clearance of iohexol. This suggests that renal prostaglandins in cats did not have a measurable effect on glomerular filtration rates in healthy, euvolemic, conscious states as determined on the basis of methods used in this study. PMID: 19566467 [PubMed - in process] (Source: American Journal of Veterinary Research)

Comparison of tepoxalin, carprofen, and meloxicam for reducing intraocular inflammation in dogs.

Conclusions and Clinical Relevance-Tepoxalin was more effective than carprofen or meloxicam for controlling the production of PGE(2) in dogs with experimentally induced uveitis. Tepoxalin may be an appropriate choice when treating dogs with anterior uveitis. PMID: 19566476 [PubMed - in process] (Source: American Journal of Veterinary Research)

Self-modeling curve resolution method applied for the evaluation of dissolution testing data: a case study of meloxicam-mannitol binary systems.

Authors: Rajk&#xF3; R, Nassab PR, Szab&#xF3;-R&#xE9;v&#xE9;sz P This paper introduces some chemometric methods, i.e., self-modeling curve resolution (SMCR), multivariate curve resolution-alternating least squares (MCR-ALS) and parallel factor analysis (PARAFAC and PARAFAC2), which are used to evaluate in vitro dissolution testing data detected by a UV-vis spectrophotometer on meloxicam-mannitol binary systems. These systems were chosen because of their relative simplicity to apply as part of the validation process illustrating the effectiveness of the developed and applied chemometric method. The paper illustrates the failure of PARAFAC methods used before for pharmaceutical data evaluations as well, and we suggest application of the feasible band form given by SMCR as a more general p...

Effects of steroidal and nonsteroidal drugs on tooth movement and root resorption in the rat molar.

Conclusions: The hypothesis was rejected. Administration of prednisolone and high-dose celecoxib reduces root resorption and interferes with tooth movement in rats. Both drugs may interfere in the arachidonic acid cascade depending on dose thresholds. PMID: 19537869 [PubMed - in process] (Source: The Angle Orthodontist)

Combined administration of gonadotropin-releasing hormone, progesterone, and meloxicam is an effective treatment for the repeat-breeder cow

In this study, we tested the hypothesis that a combined treatment would benefit the conception rate of repeat-breeder cows. The components of this regimen target ovulation defects, late progesterone (P4) rise, and premature luteolysis. In a 5-year period, 402 repeat-breeder cows were divided in five groups, and treatment regimens consisted of the following: gonadotropin-releasing hormone (GnRH; Group 1, n=115, 0.012mg buserelin im 4 to 6h before artificial insemination); P4 (Group 2, n=51, 100mg P4 intravaginally, on Days 5 to 7); meloxicam (Group 3, n=31, 0.5mgkg??1, 24h??1 melοxicam sc, on Days 16 to 18); GnRH+P4+meloxicam (Group 4, n=98); and no treatment (Group 5, control, n=107). Artificial insemination was conducted only after overt estrus; thereafter, the duration of the estrous ...<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>

Aspirin/diclofenac/meloxicam: Very late stent thrombosis: case report

(Source: Reactions)

Aspirin/diclofenac/meloxicam: Very late stent thrombosis: case report.

Page: 9 (Source: Reactions Weekly)

Efficacy of Meloxicam in a Patient With Juvenile Polyposis Syndrome.

Page: 636DOI: 10.1097/MPG.0b013e31818080abAuthors: Mangiantini, Francesca *; Lorusso, Monica *; Pozzi, Elena *; Bronzini, Francesca *; Brondello, Cristina *; Salvestrini, Camilla +; Lionetti, Paolo * (Source: Journal of Pediatric Gastroenterology and Nutrition)

Reason for the aggravation of diseases caused by inflammation and the ineffectiveness of NSAIDs on these diseases in rainy weather.

In this study, the anti-inflammatory activity of indomethacin, diclofenac, meloxicam and nimesulide were investigated on sunny and rainy days. Parallel to these experiments, the question of whether endogenous adrenaline and cortisol (corticosterone in rats) are factors that affect medicinal activity of these anti-inflammatory drugs on sunny and rainy days was examined. Our experimental results show that the drugs used produced significant anti-inflammatory effects on sunny days (76.5, 62.8, 56.9 and 64.7%, respectively) but were less effective on rainy days. On sunny days, adrenaline levels decreased by 83-86% in the groups that received indomethacin, diclofenac, meloxicam or nimesulide, compared to the control group. In contrast, there was no significant difference in corticosterone level...

Meloxicam as a Cause of Drug-Induced Autoimmune Hepatitis

Content Type Journal ArticleCategory CorrespondenceDOI 10.1007/s10620-009-0805-5Authors Pedro Martínez-Odriozola, Basurto Hospital Department of Internal Medicine Avenida de Montevideo 18 48013 Bilbao SpainAlfonso Gutiérrez-Macías, Basurto Hospital Department of Internal Medicine Avenida de Montevideo 18 48013 Bilbao SpainJoseba Ibarmia-Lahuerta, Basurto Hospital Department of Internal Medicine Avenida de Montevideo 18 48013 Bilbao SpainJosefa Muñóz-Sánchez, Basurto Hospital Department of Internal Medicine Avenida de Montevideo 18 48013 Bilbao Spain Journal Digestive Diseases and SciencesOnline ISSN 1573-2568Print ISSN 0163-2116 (Source: Digestive Diseases and Sciences)<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>

Manufacture of High-Purity Meloxicam via Its Novel Potassium Salt Monohydrate

Organic Process Research & Development, Volume 0, Issue 0, Articles ASAP (As Soon As Publishable). (Source: Organic Process Research)

In-house reference materials: 5-hydroxyflunixin and meloxicam in cow milk-preparation and evaluation.

Authors: Jedziniak P, Szprengier-Juszkiewicz T, Olejnik M Reference materials are helpful to evaluate the performance of laboratories as well as being useful for the quality control of analytical procedures. Certified reference materials and other reference materials containing non-steroidal anti-inflammatory drugs in milk are however, not available. Therefore, production and evaluation of in-house reference materials with incurred residues of 5-hydroxyflunixin (5OHFLU) and meloxicam (MEL) in cow milk has been performed. The milk was collected 12h after dosing from cows which received meloxicam (0.5 mgkg(-1) b.w., i.v., single dose) or flunixin meglumine (2.2 mgkg(-1) b.w., i.v. during three days). The concentrations of analytes were checked in the milk samples. The milk was diluted wi...

Lack of effect of naltrexone on the spinal synergism between morphine and non steroidal anti-inflammatory drugs.

Authors: Miranda HF, Pinardi G To enhance analgesia, the combinatorial use of analgesic drugs with proven efficacies is a widely-used strategy to reduce adverse side effects. The present study characterizes the antinociceptive interaction of intrathecal morphine co-administered with different NSAIDs using isobolographic analysis.Antinoceptive activity was evaluated using a model for acute visceral pain, the writhing test of mice. The possible involvement of opioid receptors in the mechanism of action of the intrathecal co-administration of morphine and NSAIDs was investigated using the non-selective receptor antagonist naltrexone. The study demonstrated a synergistic antinociception of intrathecal administered combinations of morphine with the following NSAIDs: diclofenac, ketoprofen, ...

Cyclooxygenase-2 inhibition reverts the decrease in adiponectin levels and attenuates the loss of white adipose tissue during chronic inflammation.

Authors: Granado M, Mart&#xED;n AI, Castillero E, L&#xF3;pez-Calder&#xF3;n A, Villan&#xFA;a MA Chronic arthritis leads to a decrease in body weight that is associated with a decrease in skeletal muscle and white adipose tissue mass. We have observed that overactivation of cyclooxygenase-2 (COX-2) is responsible for muscle wasting in arthritic rats. The aim of this work was to study the role of COX-2 in arthritis-induced white adipose tissue mass loss. Arthritis was induced in rats by Freund's adjuvant injection, and the effect of the COX-2 inhibitor meloxicam on serum concentrations of leptin, adiponectin, insulin and glycerol, as well as on gene expression of leptin, adiponectin, hormone-sensitive lipase (HSL), fatty acid synthase (FAS), tumour necrosis factor alpha (TNF) and insulin-...

Stability indicating HPTLC determination of meloxicam

Desai Namita, Amin PurnimaIndian Journal of Pharmaceutical Sciences 2008 70(5):644-647A simple, selective, precise and stability-indicating high-performance thin layer chromatographic method of analysis of meloxicam both as a bulk drug and in formulation has been developed. The mobile phase selected was ethyl acetate:cyclohexane:glacial acetic acid (6.5:3.5:0.02&#x0025; v/v/v). The calibration curve of the drug was linear in the range of 100-500 ng. The spectrodensitometric analysis was carried out in the absorbance mode at 353 nm. The mean (&#x00B1;RSD) values of slope, correlation coefficient and intercept were 3183.8&#x00B1;0.358, 0.9996&#x00B1;0.0321 and 13012&#x00B1;7.1 respectively. The system precision and the method precision studies were carried out with RSD of 0.83 and 1.89 respe...<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>

A randomized, double-blind, controlled trial of perioperative administration of gabapentin, meloxicam and their combination for spontaneous and movement-evoked pain after ambulatory laparoscopic cholecystectomy.

CONCLUSION: Although nausea was reduced with combination therapy, this trial provides little or no support for the combined use of meloxicam and gabapentin for pain relief on the day of surgery. This suggests that perioperative analgesic polypharmacy may not always be necessary or appropriate. PMID: 19151299 [PubMed - in process] (Source: Anesthesia and Analgesia)

Meloxicam/omeprazole/S-1/warfarin interaction: Haemorrhage, haematuria and coagulation disorders in an elderly patient: case report

(Source: Reactions)

Automated analysis of postoperative behaviour: assessment of HomeCageScan as a novel method to rapidly identify pain and analgesic effects in mice

This study evaluated whether the automated behaviour recognition software &lsquo;HomeCageScan&rsquo; (HCS) could detect behaviour changes and any positive analgesic effects in two mouse strains undergoing vasectomy (C3H/HeNCrl and C57BL/6). Another objective was to test the effectiveness of HCS in differentiating between the effects of each treatment relative to conventional manual analysis. Each control (unoperated) group consisted of four mice of each strain. They were either untreated mice, mice given meloxicam alone (10 mg/kg) or mice given either saline or meloxicam (10 mg/kg) 30 min prior to isoflurane anaesthesia. The vasectomized mice received either saline or meloxicam at 5, 10 or 20 mg/kg, again, 30 min prior to isoflurane anaesthesia. Filming began one hour following surgery. Ea...

Meloxicam/omeprazole/S-1/warfarin interaction: Haemorrhage, haematuria and coagulation disorders in an elderly patient: case report.

Page: 26 (Source: Reactions Weekly)<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>

Effect of Meloxicam Treatment during Early Pregnancy in Holstein Heifers

In this study, the objective was to determine if a single administration of meloxicam, a non-steroid anti-inflammatory drug with a longer half-life, could be used instead of flunixin meglumine. This would avoid repeated injections in heifers following insemination at a critical stage to increase pregnancy rate due to its inhibitory effect on prostaglandin F2[alpha] synthesis. Eighty-five, 15- to 18-month-old Holstein heifers were synchronized, and following insemination (day 0) heifers were assigned to receive subcutaneous meloxicam injection (0.5 mg/kg; n = 37) on the afternoon of day 15 or were untreated as a control (n = 48). Pregnancy rates were defined as the percentage of heifers inseminated that were diagnosed pregnant by ultrasound between days 31 and 38 after artificial inseminati...

Effect of Meloxicam Treatment during Early Pregnancy in Holstein Heifers.

In this study, the objective was to determine if a single administration of meloxicam, a non-steroid anti-inflammatory drug with a longer half-life, could be used instead of flunixin meglumine. This would avoid repeated injections in heifers following insemination at a critical stage to increase pregnancy rate due to its inhibitory effect on prostaglandin F(2alpha) synthesis. Eighty-five, 15- to 18-month-old Holstein heifers were synchronized, and following insemination (day 0) heifers were assigned to receive subcutaneous meloxicam injection (0.5 mg/kg; n = 37) on the afternoon of day 15 or were untreated as a control (n = 48). Pregnancy rates were defined as the percentage of heifers inseminated that were diagnosed pregnant by ultrasound between days 31 and 38 after artificial inseminati...

Meloxicam and Meloxicam-β-Cyclodextrin Complex in Model Membranes: Effects on the Properties and Enzymatic Lipolysis of Phospholipid Monolayers in Relation to Anti-inflammatory Activity

Langmuir, Volume 0, Issue 0, Articles ASAP (As Soon As Publishable). (Source: Langmuir)

A selective cyclooxygenase-2 inhibitor prevents inflammation-related squamous cell carcinogenesis of the forestomach via duodenogastric reflux in rats

Duodenal reflux causes inflammation-related squamous cell carcinogenesis in the forestomach of rats without any carcinogens. The aim of this study was to investigate the efficacy of a selective cyclooxygenase (COX)-2 inhibitor, meloxicam, in preventing this carcinogenesis.A series of 188 rats underwent a surgical duodenogastric reflux procedure and were divided into 2 groups. One group was given commercial chow (control group), and the other was given experimental chow containing meloxicam (0.3 mg/kg body weight/day) (meloxicam group). The animals were sequentially sacrificed at Weeks 20, 30, 40, 50, and 60 after surgery. The forestomach was examined for the presence of carcinoma, the incidence of reflux-related morphological changes, COX-2 expression, and its activity.At Week 60, squamous...

Interaction of Oxicam NSAIDs with lipid monolayer: Anomalous dependence on drug concentration.

Authors: Kundu S, Chakraborty H, Sarkar M, Datta A Surface pressure (pi) versus specific molecular area (A) isotherms of Langmuir monolayers of dimyristoylphosphatidylcholine (DMPC) lipid on pure water were studied in pristine form and in presence of three non-steroidal anti-inflammatory drugs, meloxicam (MX), piroxicam (PX) and tenoxicam (TX) in the subphase. Data were taken at three drug/lipid (D/L) ratios of 0.026, 0.05, and 0.1. Integration of drug to the lipid monolayer was measured by the increase in A (DeltaA) of DMPC monolayer due to the presence of drugs. All three drugs could be integrated in the monolayer resulting in a positive value of DeltaA for D/L ratio of 0.026. Above this D/L value, there is an anomalous, monotonic decrease in DeltaA for MX and TX resulting, finally, ...<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>

Characterization of ternary complexes of meloxicam-HPbetaCD and PVP or L-arginine prepared by the spray-drying technique.

Authors: El-Maradny HA, Mortada SA, Kamel OA, Hikal AH Ternary complexes of meloxicam (ME) (a poorly water soluble anti-inflammatory drug) with hydroxypropyl-beta-cyclodextrin (HPbetaCD) and either a hydrophilic polymer, namely, polyvinyl pyrrolidone (PVP) or a basic amino acid such as L-arginine, were prepared by the spray-drying technique. The solubilizing efficiency, physical properties and dissolution behaviour of each ternary system of ME-HPbetaCD with either PVP or L-arginine were compared with those of the corresponding binary system of ME-HPbetaCD. Tablets compressed from the ternary system of ME-HPbetaCD-L-arginine were compared with plain and commercial tablets. Phase solubility experiments suggested the formation of an inclusion complex of AL type. Ternary system of ME-HPbet...

Meloxicam and tenoxicam exhibited a similar and well-tolerated efficacy for analgesic and anti-inflammatory effects.

Authors: Chuang SK ARTICLE TITLE AND BIBLIOGRAPHIC INFORMATION: Comparison of analgesic and anti-inflammatory efficacy of selective and non-selective cyclooxygenase-2 inhibitors in dental implant surgery. Karabuda ZC, Bolukbasi N, Aral A, Basegmez-Zeren C, Ozdemir T. J Periodontol 2007;78(12):2284-8. LEVEL OF EVIDENCE: Level 2 (Limited-quality, patient-oriented evidence) STRENGTH OF RECOMMENDATION GRADE: Not applicable PURPOSE/QUESTION: The purpose of this study was to evaluate the analgesic and anti-inflammatory efficacy of 2 nonsteroidal anti-inflammatory drugs (NSAIDs), the selective cyclooxygenase-2 (COX-2) inhibitor drug meloxicam and the nonselective COX-2 inhibitor drug tenoxicam, by using self-related pain scores and the need for rescue-analgesic agents after dental implant sur...

Voriconazole increases while itraconazole decreases plasma meloxicam concentrations.

This study investigated the effect of voriconazole, an inhibitor of cytochrome P450 2C9 (CYP2C9) and CYP3A4, and itraconazole, an inhibitor of CYP3A4, on the pharmacokinetics and pharmacodynamics of meloxicam. Twelve healthy volunteers ingested in a cross-over study 15 mg meloxicam, without pretreatment (control), after voriconazole pretreatment, and after itraconazole pretreatment. Plasma concentrations of meloxicam, voriconazole, itraconazole and thromboxane B2 (TxB2) generation were followed. Compared to the control phase, voriconazole increased the mean area under the plasma concentration-time curve (AUC0-72) of meloxicam by 47% (P &lt; 0.001) and prolonged its mean half-life (t(1/2)); by 51% (P &lt; 0.01), without affecting its mean peak concentration (Cmax). In contrast, itraconazole...

Inhibition of Cyclooxygenase 2 in Mice Increases Production of G-CSF and Induces Radioprotection.

Authors: Hofer M, Posp&#xED;sil M, Hol&#xE1; J, Vacek A, Streitov&#xE1; D, Znojil V Hofer, M., Posp&#xED;sil, M., Hol&#xE1;, J., Vacek, A., Streitov&#xE1;, D. and Znojil, V. Inhibition of Cyclooxygenase 2 in Mice Increases Production of G-CSF and Induces Radioprotection. Radiat. Res. 170, 566-571 (2008).Meloxicam, a selective inhibitor of cyclooxygenase 2, was tested to determine its ability to modulate hematopoiesis and to influence survival of mid-lethally gamma-irradiated mice. A single dose of meloxicam (20 mg/kg) administered to mice intraperitoneally 1 h before irradiation was shown to enhance serum levels of granulocyte colony-stimulating factor (G-CSF) during the first 24 h after irradiation, to elevate numbers of granulocytic precursor cells in bone marrow and granulocyte coun...

Evaluation of Enterococcus mundtii ST4SA and Lactobacillus plantarum 423 as probiotics by using a gastro-intestinal model with infant milk formulations as substrate.

Authors: Botes M, van Reenen CA, Dicks LM Enterococcus mundtii ST4SA and Lactobacillus plantarum 423 produce bacteriocins with activity against a number of Gram-positive and Gram-negative bacteria. Both strains survived intestinal conditions simulated in a gastro-intestinal model (GIM) with infant milk formulations as substrate and prevented the growth of Listeria monocytogenes ScottA. The strains are inhibited by the antibiotics amoxicillin, cefadroxil, roxithromycin and doxycycline, anti-inflammatory medicaments containing meloxicam, ibuprofen and sodium diklofenak, and analgesics containing paracetamol, codeine phosphate and promethazine. Strain 423 is sensitive to vancomycin and does not contain genes encoding gelatinase, cell aggregation substance (AS), adhesion to collagen (Ace),...<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>

Meloxicam(Meloxicam) Tablet [Aurobindo Pharma Limited]

Updated Date: Sep 4, 2008 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

Effects of firocoxib, meloxicam, and tepoxalin on prostanoid and leukotriene production by duodenal mucosa and other tissues of osteoarthritic dogs.

Conclusions and Clinical Relevance-PG production was lower in the duodenum than in the stomach. Firocoxib had a COX-1-sparing effect in vivo. PMID: 18764695 [PubMed - in process] (Source: American Journal of Veterinary Research)

Analysis of meloxicam by high-performance liquid chromatography with cloud-point extraction.

Authors: Zhang H, Choi HK A simple cloud-point extraction method for the determination of meloxicam in human serum was developed. Meloxicam was extracted from serum sample after adding 1 mL of 3% (v/v) Triton X-114 aqueous solution in the presence of 1M HCl and 60 mg NaCl. The meloxicam, present in the surfactant-rich phase, was enriched again with acetonitrile. Tenoxicam was used as the external standard. The separation was achieved on a C18 analytical column with a mobile phase consisting of aqueous acetic acid (1%, v/v) and acetonitrile (54:46, v/v). UV detection was performed at 360 nm. The response was linear over the range 45-2000 ng mL(-1) in human serum, and intra- and interday precisions of less than 15.0% were obtained. The relative error was within +/-3.0%. The recoveries of...

The Non-steroidal Anti-inflammatory Drugs Protect Mouse Cochlea against Acoustic Injury.

This study evaluated the effects of NSAIDs on the functional recovery of the cochlea after acoustic injury. Mice were exposed to a 4-kHz pure tone of 128 dB SPL (sound pressure level) for 4 hours and received one of the following drugs for two weeks after acoustic overexposure: indomethacin (COX-1 inhibitor), meloxicam, SC58125, and CAY10404 (COX-2 inhibitors), and nordihydroguaiaretic acid (LOX inhibitor). The hearing ability was evaluated using an auditory brainstem response (ABR) before and after overexposure. The ABR threshold shifts, defined as subtraction between ABR thresholds before and after overexposure, were compared among the control and the medication groups at one and two weeks after acoustic overexposure. Treatment of mice with either indomethacin or nordihydroguaiaretic aci...

In Vitro Metabolism and Covalent Binding of Enol-Carboxamide Derivatives and Anti-Inflammatory Agents Sudoxicam and Meloxicam: Insights into the Hepatotoxicity of Sudoxicam

R. Scott Obach, Amit S. Kalgutkar, Tim F. Ryder, and Gregory S. WalkerWeb Release Date: Sat, 16 Aug 2008 00:00:00 EDT (Article) DOI: 10.1021/tx800185b (Source: Chemical Research in Toxicology)<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>

Diclofenac toxicity in Gyps vulture is associated with decreased uric acid excretion and not renal portal vasoconstriction.

Authors: Naidoo V, Swan GE Diclofenac (DF), a non-steroidal anti-inflammatory drug (NSAID), is largely regarded as one of the most devastating environmental toxicant in recent times, after accidental exposure via their food-chain lead to massive mortalities in three vulture species on the Asian subcontinent. Although the use of diclofenac was recently banned on the Indian subcontinent, following the favourable safety profile of meloxicam, its mechanism of toxicity remains unknown. In an attempt to establish this mechanism, we test three hypotheses using models established from either the domestic chicken (Gallus domesticus) or the African White-backed vulture (Gyps africanus). We demonstrate that both DF and meloxicam are toxic to renal tubular epithelial (RTE) cells following 12 h of ...

No effect of ketoprofen and meloxicam on bone graft ingrowth: a bone chamber study in goats.

Authors: van der Heide HJ, Hannink G, Buma P, Schreurs BW BACKGROUND AND PURPOSE: There is increasing awareness that non-steroidal anti-inflammatory drugs (NSAIDs), and especially the cyclooxygenase-2 (COX-2) selective ones, may retard bone healing. We have used NSAIDs (indomethacin for at least 7 days) to prevent heterotopic ossification after acetabular reconstructions using impacted bone grafts. The long-term clinical results have been satisfying, making it difficult to believe that there is an important negative effect of NSAIDs on graft incorporation. We studied the effect of two different NSAIDs on bone and tissue ingrowth in a bone chamber model in goats, using autograft, rinsed allograft, and allograft that had been rinsed and subsequently irradiated. METHODS: 9 goats received ...

Effects of meloxicam or tolfenamic acid administration on the pain and stress responses of Merino lambs to mulesing.

Conclusions The NSAID treatments applied 45 min before or at the time of mulesing at the dose levels used in this study were not effective in reducing the acute response of lambs to mulesing. PMID: 18673471 [PubMed - in process] (Source: Australian Veterinary Journal)

Pharmacokinetics of meloxicam administered as regular and fast dissolving formulations to the rat: Influence of gastrointestinal dysfunction on the relative bioavailability of two formulations.

Authors: Aghazadeh-Habashi A, Jamali F It is believed that acute pain suppresses nervus vagus, thereby, influencing gastrointestinal secretion and motility, which are the two factors that are necessary for disintegration and dissolution of solid dosage forms. We studied the pharmacokinetics of meloxicam and the effect of vagal suppression on the oral bioavailability and bioequivalence using a marketed (Brand) and a fast dissolving (FD) formulation. In simulated gastric juice, FD was disintegrated in 30s and released 30% of its meloxicam in 15min and 60% in 2h. Brand was disintegrated in 4.5min with a dissolution rate of 5.6% in 30min that stayed plateau for the 2h experiment time. To suppress the vagus nerve, intraperitoneal injection of 20mg/kg propantheline 1 and 2h before meloxicam ...

Chemoprevention of glandular stomach carcinogenesis through duodenogastric reflux in rats by a COX-2 inhibitor

Duodenogastric reflux (DGR) causes glandular stomach carcinogenesis in rats without carcinogens. We aimed to investigate how this carcinogenesis might be prevented by a selective COX-2 inhibitor, meloxicam. A series of 188 Fisher 344 rats underwent a surgical DGR procedure and were divided into 2 groups. One group was given commercial chow (control group), and the other an experimental chow containing meloxicam [0.3 mg/kg bw/day] (meloxicam group). The animals were sequentially sacrificed at weeks 20, 30, 40, 50 and 60 after surgery. The stomachs were removed and examined for the presence of carcinoma, incidence of reflux-induced morphologic changes, COX-2 expression and its activity. Adenocarcinoma in the glandular stomach developed in 7 of 21 animals (33%) in the control group at week 60...<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>

Elastic Liposomes Bearing Meloxicam-beta-Cyclodextrin for Transdermal Delivery.

Authors: Jain SK, Gupta Y, Jain A, Amin S The ultra-flexible lipid vesicles, the elastic liposomes bearing meloxicam-beta-cyclodextrin complex were prepared for its topical administration with the aim of simultaneously exploiting the favorable properties of both the carriers. The prepared meloxicam-beta-cyclodextrin complex was evaluated using DSC, XRD and FT-IR, which indicates the formation of inclusion complex in a molar ratio of 1:2 of meloxicam and beta-cyclodextrin (beta-CD). The elastic liposomes were prepared by conventional rotary evaporation method and characterized for various parameters such as vesicle shape and surface morphology, size and size distribution, entrapment efficiency, elasticity, stability and in-vitro release pattern. Permeability studies of meloxicam and mel...

Membrane fusion: A new function of non steroidal anti-inflammatory drugs.

In this study we present a new function of NSAIDs belonging to the oxicam group, as membrane fusogenic agents. Small Unilamellar Vesicles (SUVs) formed by the phospholipid, dimyristoylphosphatidylcholine (DMPC), were used as model membranes. Fluorescence assays using terbium/dipicolinic acid (Tb/DPA) were used to monitor content mixing and corresponding leakage in presence of the drugs. Transmission Electron Microscope (TEM) was also used to image fusion bodies in drug treated vesicles as compared to the untreated ones. The results show that the three oxicam NSAIDs viz. Meloxicam, Piroxicam and Tenoxicam can induce fusion of DMPC vesicles and lead the fusion process to completion at a very low drug to lipid ratio (D/L) of 0.045. The oxicam drugs exhibit differential fusogenic behavior as r...

Efficacy of tolfenamic acid and meloxicam in the control of postoperative pain following ovariohysterectomy in the cat.

Conclusions Preoperative tolfenamic acid or meloxicam reduced wound sensitivity following ovariohysterectomy in the cat. Clinical relevance Tolfenamic acid and meloxicam administered preoperatively provided a similar analgesic effect in the postoperative period lasting 24 hours. Mechanical thresholds may be a better way of evaluating postoperative analgesia provided by nonsteroidal anti-inflammatory drugs in cats. PMID: 18565201 [PubMed - as supplied by publisher] (Source: Veterinary Anaesthesia and Analgesia)

Incidence of spontaneous notifications of adverse reactions with aceclofenac, meloxicam, and rofecoxib during the first year after marketing in the United Kingdom

The objective was to compare the incidence of adverse reactions reported with three nonsteroidal anti-inflammatory drugs with different cyclo-oxygenase (COX)-2 selectivity. All spontaneous adverse reaction notifications in the pharmacovigilance database of the World Health Organisation Collaborating Centre for International Drug Monitoring with aceclofenac, meloxicam, and rofecoxib that were recorded during the first year of marketing were included. The incidence rate (adverse reactions/106 defined daily dose) and 95% confidence interval for total adverse reactions was 8.7 (6.1&ndash;12.0) for aceclofenac, 24.8 (23.1&ndash;26.6) for meloxicam, and 52.6 (49.9&ndash;55.4) for rofecoxib. Aceclofenac had a lower incidence of gastrointestinal bleeding, abdominal pain, and arterial hypertension ...

A phase II study of carboplatin and paclitacel with meloxicam.

CONCLUSIONS: Meloxicam in combination with carboplatin and weekly paclitaxel chemotherapy showed promising activity with encouraging survival. This therapy is relatively well tolerated in advanced NSCLC. PMID: 18499296 [PubMed - as supplied by publisher] (Source: Lung Cancer)<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>

Mobic(Meloxicam) Tablet Mobic(Meloxicam) Suspension [Boehringer Ingelheim Pharmaceuticals, Inc.]

Updated Date: May 5, 2008 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

Publication: Volume 12, number 11 (Chen). Clinical effectiveness and cost-effectiveness of cyclooxygenase-2 (COX-2) selective inhibitors (etodolac, meloxicam, celecoxib, rofecoxib, etoricoxib, valdecoxib and lumiracoxib) for osteoarthritis or rheumatoid arthritis.

Chief Investigator: West Midlands Health Technology Assessment Collaboration (WMHTAC), University of BirminghamResearch Type: NICE Technology Assessment Report (TAR)ICD Chapters: Bone and joint diseasesKey Areas: Improving the patient experience, older peopleInterventions: Drug treatmentICD Diseases: OsteoarthritisResearch Type: NICE Technology Assessment Report (TAR)Publication date: 16/04/2008HTA project ref: 03/34/01 (Source: HTA Programme - New projects and publications)

Mechanism of calcium hydroxide-induced neutrophil migration into air-pouch cavity.

Authors: Teixeira de Moraes Costa MM, Penha de Oliveira SH, Gomes-Filho JE The aim of this study was to investigate cellular migration induced by calcium hydroxide to air-pouch cavities in mice. The migration was more specific to neutrophil and was dose and time dependent (peaking 96 h after stimulation). This migration was inhibited by pretreatment with thalidomide, indomethacin, MK886, meloxicam, dexamethasone, MK886 associated with indomethacin, and MK886 associated with indomethacin and dexamethasone. The air-pouch exudate from animals stimulated with calcium hydroxide showed an increase of leukotriene-B(4) (LTB(4)), interleukin-1beta, tumor necrosis factor alpha (TNF-alpha), cytokine-induced neutrophil chemoattractant (KC), and macrophage inflammatory protein 2 (MIP-2) release. Pr...

Diacerein has a weak effect on the catabolic pathway of human osteoarthritis synovial fibroblast--comparison to its effects on osteoarthritic chondrocytes

Conclusions. Diacerein does not seem to reduce but rather increase inflammatory mediators in synoviocytes, while it does not overall affect chondrocyte inflammatory profile. (Source: Rheumatology)

[Mechanisms Of Signal Transduction] Oxidized Low Density Lipoprotein Activates Peroxisome Proliferator-activated Receptor-{alpha} (PPAR{alpha}) and PPAR{gamma} through MAPK-dependent COX-2 Expression in Macrophages

In conclusion, Ox-LDL-induced increase in 15d-PGJ2 level through ERK1/2-dependent COX-2 expression is one of the mechanisms of PPAR and PPAR activation in macrophages. These effects of Ox-LDL may control excess atherosclerotic progression. (Source: Journal of Biological Chemistry)<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>

Effect of anti-inflammatory agents on the integration of autogenous bone graft and bovine bone devitalized matrix in rats.

CONCLUSIONS: Diclofenac sodium and meloxicam delayed bone graft repair and dexamethasone did not interfere in it. PMID: 18372959 [PubMed - as supplied by publisher] (Source: Acta Cirurgica Brasileira)

[Tolerance to celecoxib and meloxicam in patients with intolerance to nonsteroidal anti-inflammatory drugs.]

Conclusion: We consider that there are patients with tolerance to low dosages of COX-2 inhibitors who show a reaction on increasing the administered dosage, which means that their tolerance should be taken into account and checked in the long term. PMID: 18604331 [PubMed - in process] (Source: Anales de Medicina Interna)

Orodispersible tablets of meloxicam using disintegrant blends for improved efficacy

Swamy PV, Areefulla SH, Shirsand SB, Gandra Smitha, Prashanth BIndian Journal of Pharmaceutical Sciences 2007 69(6):836-840 (Source: Indian Journal of Pharmaceutical Sciences)

Review of the cardiovascular safety of COXIBs compared to NSAIDS.

Authors: Moodley I There is no doubt that NSAIDs and COXIBS are the mainstay for managing pain and inflammation in arthritis. Overall, at therapeutically equivalent doses, both NSAIDs and COXIBs provide equivalent analgesic and anti-inflammatory efficacy. However, the gastrointestinal risk associated with NSAIDs is considerable. More recently, the cardiovascular risk associated with NSAIDs and COXIBs has become a concern. Most patients, particularly the young, can benefit from NSAIDs without the risk of serious adverse gastrointestinal or cardiovascular events. However, patients with a previous history of serious gastrointestinal complications and the elderly, who could be at risk, do require alternatives. COXIBs have significant benefits over NSAIDs in reducing the incidence of seriou...

Solid dispersion of meloxicam: Factorially designed dosage form for geriatric population.

The objective of the present work was to improve the dissolution properties of the poorly water-soluble drug meloxicam by preparing solid dispersions with hydroxyethyl cellulose (HEC), mannitol and polyethylene glycol (PEG) 4000 and to develop a dosage form for geriatric population. Differential scanning calorimetry, X-ray diffractometry, Fourier transform infrared spectroscopy and scanning electron microscopy were used to investigate the solid-state physical structure of the prepared solid dispersions. Higher in vitro dissolution of solid dispersions was recorded compared to their corresponding physical mixtures and the pure drug. PEG 4000 in 1: 9 drug to carrier ratio exhibited the highest drug release (100.2%), followed by mannitol (98.2%) and HEC (89.5%) in the same ratio. Meloxicam-PE...<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>

Meloxicam(Meloxicam) Tablet [CARACO PHARMACEUTICAL LABORATORIES, LTD.]

Updated Date: Feb 22, 2008 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

Effects of meloxicam and rofecoxib on psychomotor performance: A randomized, double-blind, placebo-controlled cross-over study

Al-Nimer Marwan S.MIndian Journal of Pharmacology 2007 39(6):291-293 (Source: Indian Journal of Pharmacology)

Urinary Human L-FABP Is a Potential Biomarker to Predict COX-Inhibitor-Induced Renal Injury.

Conclusion: Urinary L-FABP is capable of revealing chronic renal injury induced by COX inhibitors. Copyright (c) 2008 S. Karger AG, Basel. PMID: 18182783 [PubMed - as supplied by publisher] (Source: Nephron Experimental Nephrology)

Renal effect of meloxicam versus ketoprofen in anaesthetized pseudo-normovolaemic piglets.

This study demonstrates the safety of meloxicam for preemptive surgical analgesia under conditions of normovolaemia. Fluid therapy appears recommended to prevent any renal dysfunction. PMID: 18418447 [PubMed - indexed for MEDLINE] (Source: Canadian Journal of Physiology and Pharmacology)

Inhibition of cyclooxygenase-2 (COX-2) by meloxicam decreases the incidence of ovarian hyperstimulation syndrome in a rat model.

CONCLUSION(S): Our results in a rat model suggest that meloxicam has a beneficial effect on OHSS by reducing the increases in ovarian weight and VEGF expression associated with OHSS. These effects may be mediated by the COX-2 inhibitory capacity of meloxicam. PMID: 18166186 [PubMed - as supplied by publisher] (Source: Fertility and Sterility)<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>

Are COX-2 inhibitors preferable to non-selective non-steroidal anti-inflammatory drugs in patients with risk of cardiovascular events taking low-dose aspirin?

Authors: Strand V Cyclo-oxygenase-2 selective inhibitors and non-selective non-steroidal anti-inflammatory drugs (NSAIDs) are associated with increased risk of acute cardiovascular events. Only aspirin offers primary and secondary cardiovascular prophylaxis, but trials have not answered directly whether low-dose aspirin is cardioprotective with COX-2 inhibitors. A large inception cohort study showed that concomitant use of aspirin reduced risk of cardiovascular events when given with rofecoxib, celecoxib, sulindac, meloxicam, and indometacin but not when given with ibuprofen. In large trials assessing gastrointestinal safety, there were fewer gastrointestinal events in patients using both COX-2 inhibitors and aspirin than in those using non-selective NSAIDs and aspirin; significantly f...

Effect of Low-Level Laser Therapy on Inflammatory Reactions during Wound Healing: Comparison with Meloxicam

This study evaluated the action of low-level laser therapy (LLLT) on the modulation of inflammatory reactions during wound healing in comparison with meloxicam. Background Data: LLLT has been recommended for the postoperative period because of ... (Source: Photomedicine and Laser Surgery)

Anti-Tumor Effect of Non-Steroidal Anti-Inflammatory Drugs on Human Ovarian Cancers.

In this study, we examined the anti-tumor effects of the non-specific cyclooxygenase (COX) inhibitors aspirin and piroxicam, and the selective COX-2 inhibitor meloxicam on xenotransplanted ovarian cancer. Tumor growth and survival were compared in female nu/nu mice, xenografted with subcutaneous OVCAR-3 tumors or with intraperitoneal DISS tumors and treated with aspirin (200 ppm in diet, everyday), piroxicam (150 ppm in diet, everyday) or meloxicam (162 ppm in diet, everyday). Al, of the agents tested significantly suppressed the growth of OVCAR-3 tumors xenotransplanted subcutaneously as compared to the control. There was a significant difference in inhibition of OVCAR-3 tumor growth between meloxicam and aspirin treatment. Meloxicam and piroxicam treatment significantly prolonged surviva...

Meloxicam (Meloxicam) Tablet [Apotex Corp.]

Updated Date: Dec 21, 2007 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

[Original articles - Laboratory science] Effects of an ophthalmic formulation of meloxicam on COX-2 expression, PGE2 release, and cytokine expression in a model of acute ocular inflammation

Conclusion: Meloxicam treatment was more efficient than diclofenac in downregulating the expression and activity of COX-2, reducing inflammation, and modifying the inflammatory-related cytokines. (Source: British Journal of Ophthalmology)<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>

The effects of a COX-2 inhibitor meloxicam on squamous cell carcinoma of the esophagus in vivo

Our previous study showed that aspirin induced apoptosis of esophageal cancer cells in vitro by inhibiting the pathway of NF-kappaB downstream regulation of cyclooxygenase-2. The purpose of this study was to determine if similar changes occurred in vivo in the tumors of patients with SCC of the esophagus who were given a preferential COX-2 inhibitor, meloxicam. Fifty-three patients who had an esophagectomy for SCC were allocated randomly to either a Treatment group (n = 25) or a control group (n = 28). Patients in the Treatment group were given 7.5 mg/day of meloxicam, for between 10 and 14 days before surgery. Patients in the control group did not take any type of NSAID during this time interval. Samples of the tumor taken from the resected specimens were collected. Proliferation and apop...

Meloxicam: A toxicology overview

Abstract&nbsp;&nbsp;Meloxicam is a new potent non-steroidal anti-inflammatory drug (NSAID), which in animal tests exhibits potential antiarthritic action and has a wider spectrum of anti-inflammatory activity than currently available NSAIDs. Toxicological testing of meloxicam in animals suggests that acute oral overdosage is unlikely to cause severe toxicity in man. Compared with other NSAIDs, meloxicam has a relatively weak effect on gastric acid secretion and on ulceration in the rat stomach. Whereas most NSAIDs can cause parenchymal kidney damage in animals at low plasma levels and over relatively short periods, meloxicam only induces such damage in the rat over the longer term. Meloxicam preferentially inhibits cyclooxygenase-2 (COX-2), rather than cyclooxygenase-1 (COX-1), which...

The Effect of Meloxicam, a Selective COX-2 Inhibitor, on the Microvasculature of Small Metastatic Liver Tumors in Rats

Conclusions Meloxicam's anti-angiogenic activity interferes with the growth of metastatic liver tumors. Meloxicam might have therapeutic potential for liver metastasis of colorectal carcinoma. (Source: Japanese Journal of Clinical Oncology)

Meloxicam(Meloxicam) Tablet [Actavis Totowa LLC]

Updated Date: Oct 4, 2007 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

Meloxicam(Meloxicam) Tablet [Genpharm Inc.]

Updated Date: Sep 28, 2007 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>

Mobic(Meloxicam) Tablet Mobic(Meloxicam) Suspension [Boehringer Ingelheim Pharmaceuticals, Inc.]

Updated Date: Sep 14, 2007 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

Effects of meloxicam on vascular endothelial growth factor and angiopoietin-2 expression in colon carcinoma cell line HT-29

Summary&nbsp;&nbsp;To investigate the effect of meloxicam, a selected NSAIDs, on cell growth, expression of VEGF and angiopointin-2 (Ang-2) protein in HT-29 cell line, cultured HT-29 cells were treated with meloxicam of various concentrations for various lengths of time. The proliferation of HT-29 was detected by cell counting kit-8 (CCK-8), the cell cycle was determined by flow cytometer and the levels of VEGF and Ang-2 protein in supernatants were examined by enzyme linked immunosorbent assay (ELISA). The mRNA expressions of VEGF and Ang-2 in cultured HT-29 were determined by real-time quantitative reverse-transcription polymerase chain reaction. Our results showed that treatment of meloxicam of different concentrations and for various lengths of time had a cytotoxicic effect on th...

Target-controlled infusion of propofol combined with variable rate infusion of remifentanil for anaesthesia of a dog with patent ductus arteriosus.

Authors: Musk GC, Flaherty DA An 18-month-old Lurcher was anaesthetized for surgical ligation of a patent ductus arteriosus using a target-controlled infusion (TCI) of propofol and a variable rate infusion of remifentanil. Before anaesthesia, radiographic and echocardiographic examination indicated that the dog had left-sided congestive heart failure and impaired left ventricular systolic function. Ramipril and furosemide were administered pre-operatively. Following pre-anaesthetic medication with morphine, 0.5 mg kg(-1), by intramuscular injection, and pre-oxygenation, remifentanil was infused for 5 minutes at 0.2 microg kg(-1) minute(-1), followed by induction of anaesthesia using intravenous propofol administered by TCI, set at a target concentration of 3.5 microg mL(-1) of propofol...

Meloxicam(Meloxicam) Tablet [Teva Pharmaceuticals USA]

Updated Date: Aug 24, 2007 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

Synergistic interaction between meloxicam and aminoguanidine in formalin-induced nociception in mice.

CONCLUSION: Co-administration of meloxicam and aminoguanidine showed synergistic antinociceptive effect which might possibly reduce gastrointestinal toxicity associated with the use of meloxicam. PMID: 17703974 [PubMed - as supplied by publisher] (Source: European Journal of Pain)<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>

Meloxicam(Meloxicam) Tablet [CARACO PHARMACEUTICAL LABORATORIES, LTD.]

Updated Date: Aug 15, 2007 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

A comparison between the effects of meloxicam and other nsaids on the production of oxyradicals by human polymorphonuclear leucocytes

Abstract&nbsp;&nbsp;Some non-steroidal anti-inflammatory drugs (NSAIDs) inhibit the production or actions of oxygen radicals generated by polymorphonuclear leucocytes (PMNs); this mechanism may contribute towards their anti-inflammatory activity. In the present study, the effects of a new enolcarboxamide NSAID, meloxicam, on oxyradical production by human PMNs exposed to various stimuli in vitro were compared with those of other standard NSAIDs. The various stimuli employed were intended to mimic the likely synergies which occur with cytokines and bacterial production (e.g. f-met-leu-phe (fMLP) peptide) in inflamed tissues and to give an insight into the site and mechanism of action of meloxicam and related drugs on the cellular processes involved in oxyradical generation. The resu...

Subclinical carotid atherosclerosis in a patient with systemic lupus erythematosus.

Authors: Alpert D, Davis A, Erkan D, Roman MJ, Salmon JE BACKGROUND: A 41-year-old, previously healthy woman presented with chest pain, fevers, arthritis, facial rash, pericarditis, proteinuria and a positive antinuclear antibody; she was diagnosed with systemic lupus erythematosus (SLE). She initially responded well to steroids, azathioprine and hydroxychloroquine; however, disease manifestations subsequently worsened in the setting of erratic medical compliance. During this time she participated in an observational study to evaluate risk factors for the development of subclinical atherosclerosis in patients with SLE. INVESTIGATIONS: Physical examination, laboratory and serologic evaluations, echocardiography, serial carotid artery ultrasonography for detection of atherosclerotic plaq...

Antibacterials/aspirin/meloxicam: Anaphylactic reaction (first report with meloxicam): 2 case reports

(Source: Reactions)

Antibacterials/aspirin/meloxicam: Anaphylactic reaction (first report with meloxicam): 2 case reports.

Page: 7 (Source: Reactions Weekly)<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>

Agonists of protease-activated receptors 1 and 2 stimulate electrolyte secretion from mouse gallbladder

Cholecystitis is one of the most common gastrointestinal diseases. Inflammation induces the activation of proteases that can signal to cells by cleaving protease-activated receptors (PARs) to induce hemostasis, inflammation, pain, and repair. However, the distribution of PARs in the gallbladder is unknown, and their effects on gallbladder function have not been fully investigated. We localized immunoreactive PAR1 and PAR2 to the epithelium, muscle, and serosa of mouse gallbladder. mRNA transcripts corresponding to PAR1 and PAR2, but not PAR4, were detected by RT-PCR and sequencing. Addition of thrombin and a PAR1-selective activating peptide (TFLLRN-NH2) to the serosal surface of mouse gallbladder mounted in an Ussing chamber stimulated an increase in short-circuit current in wild-type but...

Nonsteroidal anti-inflammatory drugs in cats: a review.

CONCLUSIONS: Nonsteroidal anti-inflammatory drugs should be used with caution in cats because of their low capacity for hepatic glucuronidation, which is the major mechanism of metabolism and excretion for this category of drugs. However, the evidence presented supports the short-term use of carprofen, flunixin, ketoprofen, meloxicam and tolfenamic acid as analgesics in cats. There were no data to support the safe chronic use of NSAIDs in cats. PMID: 17451496 [PubMed - indexed for MEDLINE] (Source: Veterinary Anaesthesia and Analgesia)

Meloxicam, an inhibitor of cyclooxygenase-2, increases the level of serum G-CSF and might be usable as an auxiliary means in G-CSF therapy.

Authors: Hofer M, Pospíšil M, Znojil V, Holá J, Vacek A, Streitová D Hematopoiesis-modulating action of meloxicam, a cyclooxygenase-2 inhibitor, has been evaluated in mice. Increase of granulocyte colony-stimulating factor (G-CSF) serum level after meloxicam administration has been found in sublethally gamma-irradiated animals. In further experiments hematopoiesis-stimulating effects of meloxicam and G-CSF given alone or in combination have been investigated. Granulocyte/macrophage progenitor cells counts were used to monitor these effects. Meloxicam and exogenous G-CSF did not act synergistically when given in combination but could be mutually substituted during their repeated administration. The results suggest the promising possibility to use meloxicam as an auxiliary means redu...

Experimental arthritis inhibits the insulin-like growth factor-I axis and induces muscle wasting through cyclooxygenase-2 activation

Chronic arthritis induces cachexia associated with an inhibition of the growth hormone (GH)-insulin-like growth factor-I (IGF-I) system and an activation of the E3 ubiquitin-ligating enzymes muscle atrophy F-box (MAFbx) and muscle Ring finger 1 (MuRF1) in the skeletal muscle. The aim of this work was to study the role of cyclooxygenase (COX)-2 in chronic arthritis-induced cachexia. Arthritis was induced in rats by Freund's adjuvant injection, and the effects of two COX inhibitors (indomethacin, a nonspecific inhibitor, and meloxicam, a selective COX-2 inhibitor on pituitary GH and on liver and serum IGF-I levels) were tested. Arthritis decreased body weight gain and GH and liver IGF-I gene expression. In the arthritic rats, both inhibitors, indomethacin and meloxicam, prevented the inhibit...

Meloxicam(Meloxicam) Tablet [Ranbaxy Pharmaceuticals Inc.]

Updated Date: May 31, 2007 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>

Tablet Formulation Studies on Nimesulide and Meloxicam-Cyclodextrin Binary Systems

The objective of this work was to develop tablet formulations of nimesulide-?-cyclodextrin (NI-?-CD) and meloxicam-?-cyclodextrin (ME-?-CD) binary systems. In the case of nimesulide, 3 types of binary systems??physical mixtures, kneaded systems, and coevaporated systems??were studied. In the case of meloxicam, 2 types of binary systems??physical mixtures and kneaded systems??were investigated. Both drug-CD binary systems were prepared at 1:1 and 1:2 molar ratio (1:1M and 1:2M) and used in formulation studies. The tablet formulations containing drug-CD binary systems prepared by the wet granulation and direct compression methods showed superior dissolution properties when compared with the formulations of the corresponding pure drug formulations. Overall, the dissolution properties of...

Radiosensitizing potential of the selective cyclooygenase-2 (COX-2) inhibitor meloxicam on human glioma cells

Agonists of protease-activated receptors 1 and 2 stimulate electrolyte secretion from mouse gallbladder.

AGONISTS OF PROTEASE-ACTIVATED RECEPTORS 1 AND 2 STIMULATE ELECTROLYTE SECRETION FROM MOUSE GALLBLADDER. Am J Physiol Gastrointest Liver Physiol. 2007 Apr 12; Authors: Kirkland JG, Cottrell GS, Bunnett NW, Corvera CU Cholecystitis is one of the most common gastrointestinal diseases. Inflammation induces activation of proteases that can signal to cells by cleaving protease-activated receptors (PARs) to induce hemostasis, inflammation, pain and repair. However, the distribution of PARs in the gallbladder is unknown, and their effects on gallbladder function have not been fully investigated. We localized immunoreactive PAR1 and PAR2 to the epithelium, muscle and serosa of mouse gallbladder. mRNA transcripts corresponding to PAR1 and PAR2, but not PAR4, were detected by RT-PCR and ...

FDA Safety Changes: Humira, Ketek, Mobic

The Food and Drug Administration has approved revisions to the safety labeling for adalimumab injection, telithromycin tablets, and meloxicam tablets and oral suspension. (CME)Medscape Medical News (Source: Medscape Infectious Diseases Headlines)

Comparison of the influence of NSAIDs with different COX-selectivity on histamine release from mast cells isolated from naïve and sensitized rats.

Authors: Grosman N Mast cell stimulation leads to an early response with histamine release and prostaglandin (PGD(2)) production but attempts to link these two events have been contradictory. In IgE-mediated mast cell activation, a late-phase PGD(2)-production is caused by increased cyclooxygenase-2 (COX-2) expression whereas a COX-2 involvement in the early response is uncertain. The present study compares the influence of four COX-inhibitors (NSAIDs) on the histamine release of mast cells from naïve and actively sensitized rats. NSAIDs of different COX-1 vs. COX-2 selectivity were used, i.e. acetylsalicylic acid (ASA), piroxicam, meloxicam, and NS-398, a selective COX-2-inhibitor. All could inhibit antigen-induced histamine release, with 64%, 34%, 27% and 85% inhibition by ASA (5 mM...<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>

Anti-fibrotic effect of meloxicam in a murine lung fibrosis model.

Authors: Arafa HM, Abdel-Wahab MH, El-Shafeey MF, Badary OA, Hamada FM A murine lung fibrosis model has been induced by challenging male Swiss albino mice with a fibrotic dose of bleomycin (10 mg/kg body weight, s.c.) twice weekly for 6 weeks. The model has been characterized and confirmed biochemically, histologically and morphometrically. Keeping in mind that inflammation is the forerunner of lung fibrosis, we have investigated the possible anti-fibrotic effect of meloxicam; a selective COX-2 inhibitor, in this lung fibrosis paradigm. When administered ahead of bleomycin challenge, meloxicam significantly reduced the lung content of hydroxyproline; the backbone of collagen matrix. This was further confirmed by the lower collagen deposition as revealed by histochemical examination of ...

Risk of serious upper gastrointestinal events with concurrent use of NSAIDs and SSRIs: a case-control study in the general population

Conclusions??The concurrent use of SSRIs and NSAIDs is associated with a moderate excess relative risk of a serious upper GI event when compared with NSAID use alone. Content TypeJournal Article JournalEuropean Journal of Clinical PharmacologyOnline ISSN 1432-1041Print ISSN 0031-6970 (Source: European Journal of Clinical Pharmacology)

Safety of selective cyclooxygenase-2 inhibitors and a basic non-steroidal anti-inflammatory drug (NSAID) in Japanese patients with NSAID-induced urticaria and/or angioedema: Comparison of meloxicam, etodolac and tiaramide

The Journal of Dermatology Volume 34, Issue 3, Page 172-177, Mar 2007. (Source: The Journal of Dermatology)

Tolerability to nabumetone and meloxicam in patients with nonsteroidal anti-inflammatory drug intolerance.

CONCLUSION: The results of this study confirm a high percentage of tolerability to the maximum therapeutic dosage of nabumetone and meloxicam in patients with NSAID intolerance, both in those with cutaneous/mucous manifestations and in those with respiratory disease. CLINICAL IMPLICATIONS: Nabumetone and meloxicam are safe alternatives in NSAID-intolerant patients. PMID: 17292954 [PubMed - as supplied by publisher] (Source: Journal of Allergy and Clinical Immunology)

Experimental arthritis inhibits the insulin-like growth factor-I (IGF-i) axis and induces muscle wasting through cyclooxygenase-2 (COX-2) activation.

Authors: Granado M, Martin AI, Villanua MA, Lopez-Calderon A Chronic arthritis induces cachexia associated with an inhibition of the GH-IGF-I system and an activation of the E3 ubiquitin-ligating enzymes MAFbx and MuRF1 in the skeletal muscle. The aim of this work was to study the role of COX-2 in chronic arthritis-induced cachexia. Arthritis was induced in rats by Freund's adjuvant injection, and the effect of two COX inhibitors; indomethacin, a nonspecific inhibitor, and meloxicam, a selective COX-2 inhibitor, on pituitary GH, and on liver and serum IGF-I levels were tested. Arthritis decreased body weight gain and GH and liver IGF-I gene expression. In the arthritic rats, both inhibitors, indomethacin and meloxicam, prevented the inhibitory effect of arthritis on body weight gain. I...<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>

Cutaneous and ocular adverse reactions in a dog following meloxicam administration.

Authors: Niza MM, F&#xE9;lix N, Vilela CL, Peleteiro MC, Ferreira AJ The present report addresses the development of cutaneous and ocular reactions possibly related to meloxicam administration in a dog. Based on clinical signs and absence of laboratory data compatible with the other differential diagnoses considered, the possibility of an adverse drug reaction (ADR) due to meloxicam was considered. Skin biopsy revealed haemorrhage of the superficial and deep dermis, associated with hyperplasia of endothelial cells and epidermal sloughing. Vasculitis in the deep dermis was also noted. Such lesions were considered compatible with an ADR. Although the owner was not aware of any previous allergic reaction to drugs, the animal had a clinical history of atopic dermatitis. Meloxicam is a nons...

Effect of Different Cyclooxygenase Inhibitors on Gastric Adaptive Cytoprotection Induced by 20% Ethanol

In this study, we evaluated the effect of two different dosages of therapeutically prescribed nonsteroidal anti-inflammatory drugs (NSAIDs), ibuprofen, diclofenac, nimesulide, meloxicam, and celecoxib (ED80 for COX-1 and COX-2) on normal gastric mucosa and mucosa, previously exposed to 20% ethanol. At COX-2-inhibiting dosages, the NSAIDs tested were nonulcerogenic, and the same response profile was observed in ?adapted? stomachs. Interestingly, low doses of nimesulide and celecoxib increase the levels of Prostaglandin E2and COX-2, and protect against subsequent 100% ethanol exposition, suggesting that these drugs may act as ?mild irritants? to gastric mucosa. The ulcerogenic response to NSAIDs was prevented by the previous 20% ethanol exposition, probably the result of nitric oxide synthes...

Does meloxicam increase the incidence of anovulation induced by single administration of levonorgestrel in emergency contraception? A pilot study

CONCLUSIONS: The trend towards increased incidence of no follicular rupture when Melox was combined with LNG suggests that the addition of a cox-2 inhibitor has the potential to improve the contraceptive efficacy of LNG by a pre-fertilization effect. (Source: Human Reproduction)

Indirect flow-injection spectrophotometric determination of meloxicam, tenoxicam and piroxicam in pharmaceutical formulations.

Authors: Al-Momani IF A simple and sensitive indirect spectrophotometric method for the assay of meloxicam (MX), tenoxicam (TX) and piroxicam (PX) in pure and in pharmaceutical formulations by flow injection analysis (FIA) has been proposed. The method is based on the oxidation of these drugs by a known excess of N-bromosuccinimide (NBS) in an acidic medium, followed by a reaction of excess oxidant with chloranilic acid (CAA) to bleach its purple color. The absorbance values increased linearly with increasing concentrations of the drugs. Variables, such as the acidity, reagent concentrations, flow rate of reagents and other FI parameters were optimized to produce the most sensitive and reproducible results. The system obeyed Beer's low over concentration ranges of 10 - 160, 20 - 200 an...

Meloxicam tolerance in hypersensitivity to nonsteroidal anti-inflammatory drugs.

CONCLUSION: This study shows that meloxicam can be a good option for NSAID-intolerant patients: it was safe for over 95% of the patients and is easier to obtain than celecoxib or etoricoxib. However, we think that a patient should be tested in an allergy unit before it is prescribed. PMID: 17153884 [PubMed - in process] (Source: Journal of Investigational Allergology & Clinical Immunology)<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>

Nonsteroidal anti-inflammatory drugs: cyclooxygenase 2 inhibitors.

CONCLUSIONS: Selective COX 2 inhibitors are medicines that have been used in certain well-defined clinical situations and which may offer certain advantages over nonselective NSAID. Nevertheless, taking into consideration the higher cost involved and the potential for adverse cardiovascular effects, they should be employed only in accordance with strict criteria. PMID: 17136297 [PubMed - as supplied by publisher] (Source: Jornal de Pediatria)

Meloxicam, a cyclo-oxygenase 2 inhibitor, appears to have activity against liver cancer

(Source: Inpharma)

Use of cyclo-oxygenase 2 inhibitors (COX-2) and prescription non-steroidal anti-inflammatory drugs (NSAIDS) in UK and USA populations. Implications for COX-2 cardiovascular profile

We examined the experience of 10 distinct cohorts of new users of diclofenac, naproxen, ibuprofen, piroxicam, other NSAIDS, meloxicam, celecoxib, etoricoxib, rofecoxib and valdecoxib. The study period was 1 January 1995 through 2004 (31 March in UK and 28 February in USA). We collected information on covariates including history of upper GI disease, CV disease, hepatic disease, dosage, concomitant medication, and visits to a rheumatologist.We identified 486 076 unique patient-drug pairs in UK and 1 533 239 in USA. In UK population 78 201 (16%) were COX-2 users and in PharMetrics 324 206 (21%) were COX-2 users. Diclofenac and ibuprofen (NSAIDS), and celecoxib and rofecoxib (COX-2) were the agents prescribed most frequently. The duration of therapy was longer among celecoxib and rofecoxib us...

Therapeutic effect of pulsed electromagnetic field in conservative treatment of subacromial impingement syndrome

Abstract Subacromial impingement syndrome (SIS) is a frequent cause of shoulder pain. Our purpose in this double-blinded, randomized, and controlled study was to demonstrate whether the pulsed electromagnetic field (PEMF) provides additional benefit when used with other conservative treatment modalities in acute phase rehabilitation program of SIS. Forty-six patients with unilateral shoulder pain who had been diagnosed as having SIS were included in this trial. The cases were randomly separated into two groups. All cases received a treatment program for 3 weeks consisting of Codman&#8217;s pendulum exercises and subsequent cold pack gel application on shoulders with pain 5 times a day, restriction of daily activities that require the hands to be used over the head, and meloxicam tablet 15 ...

European Medicines Agency (EMEA) review concludes positive benefit-risk balance for non-selective NSAIDs and MHRA addresses safety concerns of both selective and non-selective NSAIDs

Following a review of thrombotic cardiovascular safety data, the European Medicines Agency (EMEA) has concluded that the benefit-risk balance for non-selective non-steroidal anti-inflammatory drugs (NSAIDs) remains favourable. The EMEA??s Committee for Medicinal Products for Human Use (CHMP) concluded that (taken directly from source): ? Non-selective NSAIDs are important treatments for arthritis and other painful conditions. ? It cannot be excluded that non-selective NSAIDs may be associated with a small increase in the absolute risk for thrombotic events, especially when used at high doses for long-term treatment. ? The overall benefit-risk balance for non-selective NSAIDs remains favourable when used in accordance with the product information, namely on the basis of the over...<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>

Meloxicam-associated anaphylactic reaction.

We report 2 cases of meloxicam-induced anaphylactic reaction with no sensitivity to another selective cyclooxygenase 2 inhibitor. A thorough drug allergy work-up should be done before other cyclooxygenase inhibitors are prescribed. PMID: 17039673 [PubMed - in process] (Source: Journal of Investigational Allergology & Clinical Immunology)

Safety of Meloxicam in Aspirin-Hypersensitive Patients with Asthma and/or Nasal Polyps

Int Arch Allergy Immunol 2007;142:64-69 (DOI:10.1159/000096000) (Source: Karger Publishers)

COX-2 Inhibitors and NSAIDs Have Cardiotoxic Effects

The findings from a review of observational studies suggest that diclofenac, indomethacin, and meloxicam increase cardiovascular risk as much as rofecoxib and that naproxen has a neutral effect. (CME)Medscape Medical NewsSue Hughes (Source: Medscape Nephrology Headlines)

Adverse effects of COX-2 inhibitors: more data - and is diclofenac also a risk?

Yet more data on the risks associated with COX-2 inhibitors and other NSAID. Two studies published early online by JAMA examine the cardiovascular risks associated with these drugs from observational studies, and their renal and arrhythmia effects using data from controlled trials. The two studies broadly support previous work, and are available in full online, so will be reported only briefly. The systematic review of observational studies aimed to compare the cardiovascular risks of individual NSAID and COX-2 inhibitors using data from case-control or cohort studies. A total of 23 eligible studies were located using a comprehensive literature search strategy: quality scores for the included studies were generally high. Studies on COX-2 selective inhibitors focussed on rofecoxib or cele...

Ameliorative effect of combined administration of inducible nitric oxide synthase inhibitor with cyclooxygenase-2 inhibitors in neuropathic pain in rats.

Conclusion: Co-administration of meloxicam and rofecoxib with aminoguanidine hydrochloride may be an alternative approach for the treatment of neuropathic pain. PMID: 16920373 [PubMed - as supplied by publisher] (Source: European Journal of Pain)<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>

First-Time Generic Approvals: Mobic, Propecia, Zithromax

The FDA has approved first-time generic formulations for meloxicam 7.5- and 15-mg tablets (Mobic), finasteride 1-mg tablets (Propecia), and azithromycin 100-mg-5-mL and 200-mg-5-mL oral suspension (Zithromax).Medscape Medical NewsYael Waknine (Source: Medscape Dermatology Headlines)

First-Time Generic Approvals: Mobic, Proscar, Zithromax

The FDA has approved first-time generic formulations for meloxicam 7.5- and 15-mg tablets (Mobic), finasteride 1-mg tablets (Proscar), and azithromycin 100-mg-5-mL and 200-mg-5-mL oral suspension (Zithromax).Medscape Medical NewsYael Waknine (Source: Medscape Medical News Headlines)

Actavis Launches Meloxicam Tablets For The Relief Of Signs And Symptoms Of Osteoarthritis And Rheumatoid Arthritis

Actavis U.S., theUnited States manufacturing and marketing division of the internationalgeneric pharmaceutical company Actavis Group (ICEX: ACT), received approvalfrom the U.S. Food & Drug Administration to market Meloxicam Tablets.Shipment of the product will begin immediately. Meloxicam Tablets, the generic equivalent of Boehringer Ingelheim'sMobic(R) Tablets, are available in both 7.5 mg and 15 mg strengths. [click link for full article] (Source: Arthritis News From Medical News Today)

meloxicam, Mobic

Title: meloxicam, MobicCategory: MedicationsCreated: 11/8/2000 8:38:00 PMLast Editorial Review: 7/26/2006 (Source: MedicineNet Chronic Pain General)

Mylan Announces Final Approval For Meloxicam Tablets

Mylan Laboratories Inc.(NYSE: MYL) today announced that the U.S. Food and Drug Administration hasgranted final approval for Mylan Pharmaceuticals Inc.'s Abbreviated NewDrug Application for Meloxicam Tablets, 7.5 mg and 15 mg. Meloxicam Tablets are indicated for the relief of the signs andsymptoms of osteoarthritis. They are the AB-rated generic equivalent ofBoehringer Ingelheim's Mobic(R) Tablets, which had annual U.S. sales ofapproximately $1. [click link for full article] (Source: Arthritis News From Medical News Today)<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>

Lupin Announces Approval of Meloxicam Tablets

BALTIMORE, July 20 /PRNewswire/ -- Lupin Pharmaceuticals, Inc. announced today that the U.S. Food and Drug Administration (FDA) has granted final approval for its Abbreviated New Drug Application (ANDA) for Meloxicam Tablets, 7.5 mg and 15 mg. The Company intends to initiate shipments immediately. Lupin's Meloxicam Tablets are... (Source: Drug Newswire)

Mylan Announces Final Approval for Meloxicam Tablets

PITTSBURGH, July 20 /PRNewswire-FirstCall/ -- Mylan Laboratories Inc. (NYSE:MYL) today announced that the U.S. Food and Drug Administration has granted final approval for Mylan Pharmaceuticals Inc.'s Abbreviated New Drug Application for Meloxicam Tablets, 7.5 mg and 15 mg. Meloxicam Tablets are indicated for the relief of the signs... (Source: Drug Newswire)

Teva's rheumatoid-arthritis generic OK'd

The Food and Drug Administration approved Teva Pharmaceutical Industries Ltd.'s new drug application for Meloxicam tablets, a treatment for the signs and symptoms of osteoarthritis and rheumatoid arthritis. (Source: bizjournals.com Health Care:Pharmaceuticals headlines)

Lupin Announces Approval Of Meloxicam Tablets

Lupin Pharmaceuticals, Inc.announced today that the U.S. Food and Drug Administration (FDA) hasgranted final approval for its Abbreviated New Drug Application (ANDA) forMeloxicam Tablets, 7.5 mg and 15 mg. The Company intends to initiateshipments immediately. Lupin's Meloxicam Tablets are the AB-rated generic equivalent ofBoehringer Ingelheim's MOBIC(R) Tablets. [click link for full article] (Source: Health News from Medical News Today)

Par Pharmaceutical Receives Final Approval to Market Meloxicam Tablets

SPRING VALLEY, N.Y., July 19 /PRNewswire-FirstCall/ -- Par Pharmaceutical Companies, Inc. (NYSE:PRX) today announced that it has received final approval from the U.S. Food and Drug Administration for its Abbreviated New Drug Application for meloxicam tablets, 7.5 mg and 15 mg. Meloxicam is the generic version of Boehringer Ingelheim's Mobic(R)... (Source: Drug Newswire)

Caraco Pharmaceutical Laboratories, Ltd. Announces FDA Approval to Market Generic Mobic(R)

DETROIT, July 19 /PRNewswire-FirstCall/ -- Caraco Pharmaceutical Laboratories, Ltd., (AMEX:CPD) announced today that the U.S. Food and Drug Administration (FDA) has granted final approval for the Company's Abbreviated New Drug Application (ANDA) for Meloxicam Tablets. Caraco's Meloxicam Tablets is the generic equivalent of Boehringer Ingelheim's Mobic(R) a nonsteroidal... (Source: Drug Newswire)

Caraco Pharmaceutical Laboratories, Ltd. Announces FDA Approval To Market Generic Mobic(R)

Caraco PharmaceuticalLaboratories, Ltd., (Amex: CPD) announced today that the U.S. Food and DrugAdministration (FDA) has granted final approval for the Company'sAbbreviated New Drug Application (ANDA) for Meloxicam Tablets. Caraco's Meloxicam Tablets is the generic equivalent of BoehringerIngelheim's Mobic(R) a nonsteroidal anti-inflammatory drug, (NSAID) whichis indicated for the relief of the signs and symptoms of osteoarthritis. [click link for full article] (Source: Arthritis News From Medical News Today)

Delay of Ovulation by Meloxicam in Healthy Cycling Volunteers: A Placebo-Controlled, Double-blind, Crossover Study

This study aimed to assess the effect of meloxicam on female ovulation. Twenty consented fertile females were monitored for 4 menstrual cycles: a baseline cycle, 2 treatment cycles, and a washout cycle between treatment cycles. In the first cycle visit, transvaginal ultrasound was performed, a blood sample for progesterone and meloxicam analysis was withdrawn, and volunteers were given a luteinizing hormone (LH) urine test kit and meloxicam or placebo. Volunteers started the treatment on the following day and asked to return the day the LH kit was positive to detect the dominant follicle. At subsequent visits, transvaginal ultrasound and progesterone and meloxicam levels were investigated. Compared to placebo, a 5-day delay in follicle rupture, a 55.7% increase in the mean maximum follicle...

Differential Effects of Selective Cyclooxygenase (COX)-1 and COX-2 Inhibitors on Anorexic Response and Prostaglandin Generation in Various Tissues Induced by Zymosan.

Authors: Naoi K, Kogure S, Saito M, Hamazaki T, Watanabe S We have shown that anorexic response is induced by intraperitoneal injection of zymosan in mice, although the role of prostaglandins in this response is relatively unknown as compared with lipopolysaccharide (LPS)-induced anorexic response. Indomethacin (0.5 and 2.0 mg/kg), a non-selective cyclooxygenase (COX) inhibitor, as well as meloxicam (0.5 mg/kg), a selective COX-2 inhibitor, but not FR122047 (2.0 mg/kg), a selective COX-1 inhibitor, attenuated zymosan-induced anorexia. Zymosan injection elevated COX-2 expression in brain and liver but not in small intestine and colon. Meloxicam (0.5 mg/kg) and FR122047 treatment (2.0 mg/kg) similarly suppressed the generation of brain prostaglandin E(2) (PGE(2)) and peritoneal prostacyc...<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>

NSAID use and the risk of hospitalization for first myocardial infarction in the general population: a nationwide case-control study from Finland

Conclusion Current use of all NSAIDs is associated with a modest risk of first time MI. (Source: European Heart Journal)

Specific COX-2 inhibitor, meloxicam, suppresses proliferation and induces apoptosis in human HepG2 hepatocellular carcinoma cells

Journal of Gastroenterology and Hepatology Volume 0, Issue 0, Page ???-??? (Source: Journal of Gastroenterology and Hepatology)

Meloxicam inhibits osteosarcoma growth, invasiveness and metastasis by COX-2-dependent and independent routes

Cyclooxygenase-2 (COX-2) inhibitors exert antitumor activity via COX-2-dependent and independent pathways. We wished to evaluate the antitumor activity of meloxicam, a preferential COX-2 inhibitor, in osteosarcoma, the most common primary malignant bone tumor, and determine whether its antitumor effect is COX-2-dependent. COX-2 expression in the osteosarcoma cell lines MG-63, HOS and U2-OS was determined by real-time RT&ndash;PCR and western blotting. Subsequently, the inhibitory effects of meloxicam on osteosarcoma cell growth and invasiveness were assayed by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide and matrigel invasion assays, respectively. Apoptotic activity was evaluated by terminal deoxynucleotidyltransferase-mediated dUTP nick end labeling staining and semi-quant...

Aspirin and NSAID sensitivity.

Authors: Stevenson DD Aspirin and the older nonsteroidal anti-inflammatory drugs (NSAIDs) that block cyclo-oxygenase-1 (COX-1) induce asthma attacks in patients with aspirin-exacerbated respiratory disease and urticaria in patients with chronic idiopathic urticaria. Weak inhibitors of COX-1, such as acetaminophen and salsalate, crossreact also but only with high doses of the drugs. Partial inhibitors of both COX-1 and COX-2, such as nimesulide and meloxicam, also cross-react but only at high drug doses. COX-2 inhibitors do not cross-react; however, all NSAIDs, including the selective COX-2 inhibitors, can sensitize patients and induce urticaria or anaphylaxis on next exposure to the drug. PMID: 15242723 [PubMed - indexed for MEDLINE] (Source: Immunology and Allergy Clinics of North...

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