OMEPRAZOLE MAGNESIUM (Omeprazole Magnesium 20.6mg Capsules) Capsule, Delayed Release [Wal-Mart Stores Inc]

Updated Date: Feb 18, 2014 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

OMEPRAZOLE MAGNESIUM Capsule, Delayed Release [Chain Drug Consortium, LLC ]

Updated Date: Feb 18, 2014 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

OMEPRAZOLE MAGNESIUM Capsule, Delayed Release [Kaiser Permanente]

Updated Date: Feb 18, 2014 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

OMEPRAZOLE MAGNESIUM Capsule, Delayed Release [Chain Drug Marketing Association]

Updated Date: Feb 18, 2014 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

High resolution magic angle spinning NMR as a tool for unveiling the molecular enantiorecognition of omeprazole by amylose-based chiral phase

Analyst, 2014, Advance ArticleDOI: 10.1039/C3AN02029K, PaperJuliana Cristina Barreiro, Tiago de Campos Lourenco, Lorena Mara A. Silva, Tiago Venancio, Quezia Bezerra CassThis work reports key information about the enantiorecognition of omeprazole at the binding sites of the polysaccharide-based chiral stationary phase.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Analyst latest articles)<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>

Comparing omeprazole with fluoxetine for treatment of patients with heartburn and normal endoscopy who failed once daily proton pump inhibitors: Double‚?źblind placebo‚?źcontrolled trial

Conclusions & InferencesFluoxetine was superior to omeprazole for improving the symptoms of patients with heartburn and normal endoscopy who failed once daily PPIs. The superiority of fluoxetine was mostly attributed to those with normal esophageal pH rather than those with abnormal pH (ClinicalTrials.gov, number NCT01269788). We aimed to compare efficacy of fluoxetine with omeprazole and placebo to achieve symptomatic relief in patients with heartburn and normal endoscopy who failed once daily proton pump inhibitor (PPIs). We observed that fluoxetine was superior to omeprazole for improving the symptoms of patients with heartburn and normal endoscopy who failed once daily PPIs. The superiority of fluoxetine was mostly attributed to those with normal esophageal pH rather than those wi...

Positive Clinical Response to Clopidogrel IS Independent of Paraoxonase 1 Q192R and CYP2C19 Genetic Variants.

Authors: Mart√≠nez-Quintana E, Medina-Gil JM, Rodr√≠guez-Gonz√°lez F, Garay-S√°nchez P, Limi√Īana JM, Saavedra P, Tugores A Abstract There is increasing controversy about the influence of serum paraoxonase type 1 and cytochrome CYP2C19 in the conversion of clopidogrel to its pharmaceutically active metabolite. The effect of concomitant medication with the proton pump inhibitor omeprazole has been also subject of intense scrutiny. PMID: 24504666 [PubMed - as supplied by publisher] (Source: The Journal of Clinical Pharmacology)

OMEPRAZOLE Capsule, Delayed Release [Preferred Pharmaceuticals, Inc.]

Updated Date: Feb 5, 2014 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

Perception of the Usefulness of Drug/Gene Pairs and Barriers for Pharmacogenomics in Latin America.

Authors: Qui√Īones L, Lavanderos M, Cayun J, Garc√≠a-Martin E, Ag√ļndez J, Caceres D, Roco A, Morales J, Herrera L, Encina G, Isaza C, Redal M, Larovere L, Soria N, Eslava-Schmalbach J, Castaneda-Hernandez G, Lopez-Cortes A, Magno L, Lopez M, Chiurillo M, Rodeiro I, Castro de Guerra D, Teran E, Carrizo E, Lares-Assef F Abstract Pharmacogenetics and Pharmacogenomics areas are currently emerging fields focused to manage pharmacotherapy that may prevent undertreatment while avoiding associated drug toxicity in patients. Large international differences in the awareness and in the use of pharmacogenomic testing are presumed, but not well assessed to date. In the present study we review the awareness of Latin American scientific community about pharmacogenomic testing and the perceived b...

Obliteration of symptomatic Schatzki rings with jumbo biopsy forceps (with video)

The objective of our study was to evaluate the feasibility of complete excision of the ring using jumbo cold biopsy forceps. Our main outcome measurements were the feasibility, safety, and efficacy of complete obliteration of Schatzki rings using jumbo cold biopsy forceps. We designed an observational study using a standard protocol for patient management and data collection using a university hospital as our setting. We followed 10 patients with dysphagia due to a Schatzki's ring, six of whom had previously undergone bougienage or balloon dilation. Five patients were on maintenance therapy with a proton pump inhibitor and one with an H2 blocker. Complete endoscopic obliteration of the Schatzki rings with a cold jumbo biopsy forceps was achieved in all 10 patients requiring a mean of 9.8 b...<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>

OMEPRAZOLE Capsule, Delayed Release [American Health Packaging]

Updated Date: Jan 30, 2014 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

OMEPRAZOLE Capsule, Delayed Release [Aidarex Pharmaceuticals LLC]

Updated Date: Jan 28, 2014 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

Persistent Oral Manifestations in Woman With Pemphigus Vulgaris: Case Report

This report shows the possible occurrence of resistant oral lesions in PV and the need for dentists to have extensive knowledge about this entity to provide correct management. (Source: Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontics)

Simultaneous LC-MS/MS Analysis of the Plasma Concentrations of a Cocktail of 5 Cytochrome P450 Substrate Drugs and Their Metabolites.

In conclusion, the advantage of our cocktail approach is that it enables in vivo assessment of the activity of various drug-metabolizing enzymes in a single assay. PMID: 24389476 [PubMed - in process] (Source: Biological and Pharmaceutical Bulletin)

An open cluster-randomized, 18-month trial to compare the effectiveness of educational outreach visits with usual guideline dissemination to improve family physician prescribing

DiscussionThis trial will attempt to address unresolved issues in the literature, namely, long term persistence of effect, the importance of sequential visits in an outreach program, and cost issues. If successful, this trial may be the cornerstone for deploying large scale educational outreach programs within the Portuguese National Health Service.Trial registration: ClinicalTrials.gov number NCT01984034. (Source: Implementation Science)<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>

OMEPRAZOLE Capsule [New Horizon Rx Group, LLC]

Updated Date: Jan 2, 2014 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

Randomised clinical trial comparing sequential and concomitant therapies for Helicobacter pylori eradication in routine clinical practice

Conclusions Concomitant therapy led to a non-statistically significant advantage (5%) over sequential therapy, coming closer to 90% cure rates. Both therapies showed an acceptable safety profile. ClincialTrials.gov: NCT01273441. (Source: Gut)

Pharmacokinetic and Pharmacodynamic Alterations in the Roux-en-Y Gastric Bypass Recipients: Tandra S, Chalasani N, Jones DR et al. Ann¬†Surg 2013;258:262‚??9.

This group from Indiana University School of Medicine conducted pharmacokinetic (PK) and pharmacodynamic (PD) studies to ascertain the effect of altered foregut anatomy due to Roux-en-Y gastric bypass (RYGB) on oral drug absorption, bioavailability, and effectiveness. For the PK study, the group enrolled 18 study and control patients that were age-, sex-, race-, and body mass index (BMI)-matched volunteers > 18 years of age. All the study patients were at least 1 year post RYGB surgery at the time of enrollment. All participants were placed on a standard clinical pharmacology diet for 2 weeks prior to the study through its conclusion and were instructed to avoid ethanol, caffeine, and other xanthine-related products for 2 days prior to the study. Patients on medications known to alter cyto...

The effect of perioperative proton pump inhibitors on the incidence of pharyngocutaneous fistula following total laryngectomy: A prospective randomized controlled trial

CONCLUSIONS Pharyngocutaneous fistulae result in prolonged hospitalization and morbidity. We observed a statistically significant reduction in fistulae with PPI prophylaxis. Further research to better define the role of reflux and antacid management is suggested. Head Neck, 2013 (Source: Head and Neck)

Pharmacokinetics of different formulations of oral azacitidine (CC-486) and the effect of food and modified gastric pH on pharmacokinetics in subjects with hematologic malignancies.

Authors: Laille E, Savona MR, Scott BL, Boyd TE, Dong Q, Skikne B Abstract Parenteral azacitidine improves overall survival in higher-risk myelodysplastic syndromes. An oral azacitidine formulation would allow extended dosing schedules, potentially improving safety and/or efficacy. Two Phase 1 studies evaluated the pharmacokinetics (PK) of oral azacitidine in subjects with hematologic malignancies. Study 1 evaluated different oral formulations (immediate release tablet [IRT], enteric-coated tablet, and capsule; N‚??=‚??16). Study 2 assessed the effect of food (Part 1; N‚??=‚??17) and gastric pH modulation with omeprazole (Part 2; N‚??=‚??14) on oral azacitidine PK. Azacitidine plasma concentration-time profiles for IRT and capsule formulations were similar, with more rapid time to ...<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>

Daily low-dose aspirin can prevent heart attack and stroke but is often misused

Aspirin is often hailed as a wonder drug, thanks to its ability to help stave off heart attacks and clot-caused strokes. But fewer than half of people who could benefit from a daily low-dose aspirin take it, while many others take it when they shouldn't, reports the January 2014 Harvard Heart Letter. If you don't have heart disease, but do have high blood pressure, diabetes, or other risk factors for heart disease, don't automatically assume that taking aspirin every day is a good idea. "A lot of people take aspirin who really shouldn't," says Dr. Christopher Cannon, a cardiologist at Brigham and Women's Hospital and professor of medicine at Harvard Medical School. "Everyone assumes aspirin is harmless, but it isn't." For some, the downsides of aspirin&mdash;mainly gastrointestinal bleedin...

OMEPRAZOLE Capsule, Delayed Release [Clinical Solutions Wholesale]

Updated Date: Dec 19, 2013 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

High resolution magic angle spinning NMR as a tool for unveiling the molecular enantiorecognition of omeprazole by amylose-based chiral phase.

Analyst, 2013, Accepted ManuscriptDOI: 10.1039/C3AN02029K, PaperJuliana Cristina Barreiro, Tiago Campos Lourenco, Lorena Mara Alexandre e Silva, Tiago Venancio, Quezia Bezerra CassPolysaccharide-based chiral stationary phases (CSP) demonstrate great versatility and higher chiral selectivity for a variety of chiral compounds on multimodal elution mode (normal, reverse and polar organic). The main role...The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Analyst latest articles)

AstraZeneca awarded $76 million from Apotex for Prilosec generic

NEW YORK (Reuters) - A U.S. federal judge has awarded AstraZeneca Plc $76 million in damages from generic drug manufacturer Apotex for infringing upon patents for AstraZeneca's blockbuster heartburn drug, Prilosec, between 2003 and 2007. (Source: Reuters: Health)

The Stereoselectivity of CYP2C19 on R‚?ź and S‚?źisomer of Proton Pump Inhibitors

This article is protected by copyright. All rights reserved. Some key residues responsible for the selective binding for R‚?ź and S‚?źisomers of omeprazole, lansoprazole and pantoprazole are disclosed by free energy and alanine scanning analysis. Structural analysis showed that chiral isomers of PPIs employed three conformations in order to have strong binding affinities with CYP2C19. Based on energetic and structural results, a theoretical pharmacophore model was obtained with the importance of pharmacophore feature being weighted. (Source: Chemical Biology and Drug Design)<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>

Simultaneous and comprehensive in vivo analysis of cytochrome P450 activity by using a cocktail approach in rats

In conclusion, a cocktail approach was developed for simultaneous and comprehensive analysis of the activities of multiple CYP isoforms in rats. In this approach, the effects of inhibitors and an inducer of various CYP isoforms were examined. Although further studies are necessary to predict effects in humans, this approach may be expected to serve as a convenient method for detecting drug‚?źdrug interactions in rats. This article is protected by copyright. All rights reserved. (Source: Biopharmaceutics and Drug Disposition)

Evaluation and management of hypersensitivity to proton pump inhibitors.

CONCLUSION: The HSRs to PPIs should be formally investigated, especially when reasonable alternative therapies do not exist. The reviewers propose an evidence-based algorithm for evaluating and managing patients with an HSR to a PPI. PMID: 24267357 [PubMed - in process] (Source: Annals of Allergy, Asthma and Immunology)

Development and validation of a capillary electrophoresis method for determination of enantiomeric purity and related substances of esomeprazole in raw material and pellets

A capillary electrophoresis method using cyclodextrins for quality control of esomeprazole (ESO) in terms of enantiomeric purity and related substances in raw material and pellets was developed. ESO is the S‚?źenantiomer of omeprazole (OMZ). Several parameters were evaluated, including type and concentration of buffer and cyclodextrin, concentration of additives and electrolyte pH. Resolution between the enantiomers of OMZ obtained for each parameter tested was calculated and the presence of the main related substance like omeprazole sulfone was carefully monitored. The optimized system consisted of 100 mM Tris‚?źphosphate buffer pH 2.5 with 20 mM 2‚?źhydroxypropyl‚?źő≤‚?źcyclodextrin, 1 mM sodium dithionite, temperature at 15¬įC, voltage at 28 kV, UV detection at 301 nm. Once optimized, t...

Using Acid Reflux Medications Wisely

If you decide to take medication for any medical condition, you should know how to take that medication wisely. Up to half of all those who take medications do not take them as directed. This could be the result of not reading the labels on the prescriptions bottles or on the bottles of the over the counter meds, missing doses, using medication after it's expiration date, etc. In order to make sure you lower your risk of having problems with the medications you take, you can follow the tips in this article on using medications wisely. Related Resources: Antacids Maalox Mylanta Tums Gaviscon Chooz H2 Blockers Axid Pepcid Tagamet Zantac Proton Pump Inhibitors Aciphex Dexilant Nexium Prevacid Prilosec Protonix Using Acid Reflux Medicat...

Effects of rabeprazole on the antiplatelet effects and pharmacokinetics of clopidogrel in healthy volunteers.

CONCLUSIONS: Rabeprazole does not interact with clopidogrel to the same extent as omeprazole. However, under our experimental conditions and proton-pump inhibitor doses, there was no significant pharmacodynamic interaction between rabeprazole or omeprazole and clopidogrel, despite a significant decrease in the formation of clopidogrel active metabolite. PMID: 24246616 [PubMed - as supplied by publisher] (Source: Archives of Cardiovascular Diseases)<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>

A New Algorithm for Weekly Phenprocoumon Dose Variation in a Southern Brazilian Population: Role for CYP2C9, CYP3A4/5 and VKORC1 Genes Polymorphisms

This article is protected by copyright. All rights reserved. (Source: Basic and Clinical Pharmacology and Toxicology)

One-Time Procedure Could Prevent Acid Reflux

function cbs_video_wnplayer_9509573_start() { var WNVideoCanvas_vid9509573 = new WNVideoWidget("WNVideoCanvas", "WNVideoCanvas_vid9509573", "1"); //Playback options WNVideoCanvas_vid9509573.SetVariable("widgetId", 9509573); WNVideoCanvas_vid9509573.SetVariable("addThisDivId", "WNVideoCanvas_vid9509573_addThis"); WNVideoCanvas_vid9509573.SetVariable("incanvasAdDivId", "WNVideoCanvas_vid9509573_adDiv"); WNVideoCanvas_vid9509573.SetVariable("clipId", "9509573"); // Controls options WNVideoCanvas_vid9509573.SetVariable("isMute", "false"); WNVideoCanvas_vid9509573.SetVariable("isAutoStart", "false"); WNVideoCanvas_vid9509573.SetVariable("controlsType", "fixed"); //AdRevenue settings WNVideoCanvas_vid9509573.SetReportingKeywords("CBS.BOSTON"); WNVideoCanvas_vid9509573...

Relaxant effect of proton pump inhibitors on in vitro myometrium from pregnant women.

CONCLUSION: These data, together with the fact that PPIs almost do not present side effects, suggest that these drugs can offer new therapeutic strategies for preterm delivery. Undoubtedly, further investigations and clinical studies are necessary before adding PPIs to the list of drugs available for the treatment of preterm delivery. PMID: 24215738 [PubMed - as supplied by publisher] (Source: European Journal of Pharmaceutical Sciences)

Healing effects of Musa sapientum var. paradisiaca in diabetic rats with co-occurring gastric ulcer: Cytokines and growth factor by PCR amplification

Conclusion: MSE showed antidiabetic and better ulcer healing effects compared with OMZ (antiulcer) or INS (antidiabetic) in diabetic rat and could be more effective in diabetes with concurrent gastric ulcer. (Source: BMC Complementary and Alternative Medicine)

Proton pump inhibitor‚?źinduced subacute cutaneous lupus erythematosus

ConclusionsWe present the largest case series of PPI‚?źinduced SCLE reported to date and our patient cohort evidence the lack of attention to this condition. The diagnosis may be suspected on the clinical picture and most patients have anti‚?źRo/SSA antibodies, while anti‚?źhistone antibodies have no value in the diagnostic process. Cross‚?źreactivity can be seen between different PPIs.This article is protected by copyright. All rights reserved. (Source: British Journal of Dermatology)<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>

PA tablets: investigational compounds combining aspirin and omeprazole for cardioprotection

Future Cardiology , November 2013, Vol. 9, No. 6, Pages 785-797. (Source: Future Cardiology)

Omeprazole increased small intestinal mucosal injury in two of six disease‚?źfree cases evaluated by capsule endoscopy

Recently, a report showed that proton‚?źpump inhibitors (PPI) exacerbate non‚?źsteroidal anti‚?źinflammatory drug‚?źinduced small intestinal injury in the rat. In the present report of two human cases, small intestinal injuries were probably induced and/or exacerbated after PPI treatment. Case 1 was a 30‚?źyear‚?źold healthy man in whom no small intestinal mucosal break was detected at baseline capsule endoscopy. After 2 weeks of omeprazole given 20‚??mg once daily, he was found to have two small intestinal mucosal breaks. Case 2 was a 40‚?źyear‚?źold healthy man in whom six small intestinal mucosal breaks were detected at baseline capsule endoscopy. After 2 weeks of omeprazole given 20‚??mg once daily, 12 small intestinal mucosal breaks were detected. Follow‚?źup capsule endoscopy carried...

Application of a novel 3-fluid nozzle spray drying process for the microencapsulation of therapeutic agents using incompatible drug-polymer solutions.

Authors: Sunderland T, Kelly JG, Ramtoola Z Abstract The aim of this study was to evaluate a novel 3-fluid concentric nozzle (3-N) spray drying process for the microencapsulation of omeprazole sodium (OME) using Eudragit L100 (EL100). Feed solutions containing OME and/or EL100 in ethanol were assessed visually for OME stability. Addition of OME solution to EL100 solution resulted in precipitation of OME followed by degradation of OME reflected by a colour change from colourless to purple and brown. This was related to the low pH of 2.8 of the EL100 solution at which OME is unstable. Precipitation and progressive discoloration of the 2-fluid nozzle (2-N) feed solution was observed over the spray drying time course. In contrast, 3-N solutions of EL100 or OME in ethanol were stable ov...

The effect of single- and multiple-dose etravirine on a drug cocktail of representative cytochrome P450 probes and digoxin in healthy subjects.

Authors: Kakuda TN, Van Solingen-Ristea RM, Onkelinx J, Stevens T, Aharchi F, De Smedt G, Peeters M, Leopold L, Hoetelmans RM Abstract The effect of etravirine on cytochrome P450 (CYP) enzymes and P-glycoprotein were evaluated in two randomized, cross over trials in healthy subjects. A modified Cooperstown 5‚??+‚??1 cocktail was utilized to determine the effects of etravirine on single-dose pharmacokinetics of model CYP probes. The cocktail was administered alone, then, after a 14-day washout, etravirine 200‚??mg twice daily (bid) was given for 14 days with cocktail on days 1 and 14. In a separate study, digoxin (0.5‚??mg) was administered alone, then, after a 14-day washout, etravirine 200‚??mg bid was administered for 12 days with digoxin on day 8. In the cocktail study, the leas...

Combination of omeprazole with GLP-1 agonist therapy improves insulin sensitivity and antioxidant activity in liver in type 1 diabetic mice.

Conclusion: We conclude that combination with omeprazole improves the insulin sensitizing actions of GLP-1 therapy and these effects are partially mediated through the decrease in hepatic steatosis and improvement in antioxidant status in the liver. PMID: 24145087 [PubMed - in process] (Source: Pharmacological Reports)<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>

Effect of repeated doses of netazepide, a gastrin receptor antagonist, omeprazole and placebo on 24‚??h gastric acidity and gastrin in healthy subjects

ConclusionAlthough repeated doses of netazepide led to tolerance to its effect on pH, the accompanying increase in plasma gastrin is consistent with continued inhibition of acid secretion, via gastrin receptor antagonism and gene up‚?źregulation. (Source: British Journal of Clinical Pharmacology)

In vitro characterization of acid secretion in the gilthead sea bream (Sparus aurata) stomach.

Authors: M√°rquez L, Fuentes J Abstract The gastric acid secretion of juvenile Sparus aurata was characterized in Ussing chambers; secretion rates were determined by a pH-stat method at pH5.50 and bioelectrical parameters were measured in current-clamped tissues. The basal secretion equaled 535¬Ī87nmol¬∑cm(-2)¬∑h(-1). Serosal carbachol 100őľM produced an increase (ő?JH+) of 725¬Ī133nmol¬∑cm(-2)¬∑h(-1) from basal secretion, this effect being inhibited by mucosal omeprazole 100őľM. Basal secretion was also sensitive to the combination of serosal forskolin (FK) 10őľM+serosal isobutylmethylxanthine (IBMX) 100őľM (ő?JH+=793¬Ī239nmol¬∑cm(-2)¬∑h(-1)); this effect was insensitive to mucosal omeprazole 100mM but inhibited by mucosal bafilomycin A1 100 nM. The effect of carbachol proceeded w...

Pathway links heartburn and esophageal cancer

Got heartburn? More than 60 million adults in the U.S. have acid reflux, or heartburn, and approximately 10 percent are at risk for developing esophageal cancer, due in part to complications from Barrett's esophagus. But researchers at Rhode Island Hospital discovered a pathway they believe links Barrett's esophagus to the development of esophageal cancer. Their data suggest that blocking this pathway, such as with a proton pump inhibitor (e.g. omeprazole), may prevent the development of esophageal cancer... (Source: Health News from Medical News Today)

Recurrent headaches: a case of neurological Behçet's disease.

Authors: M Ismail A, W Dubrey S, C Patel M Abstract A 48-year-old black male, of Nigerian heritage, presented with a 24-hour history of frontal headache of gradual onset. The headache characteristic was migranous, being described as throbbing in nature and located to the right frontal area with associated blurring of vision. Although similar to prior frequent headaches, there was now increasing unsteadiness on walking. Diagnosed 10 years earlier with Behçet's disease, the initial presentation was with oral and genital ulceration. Recurrent episodes of headache caused by neurological flare-ups resulted in a stroke at the age of 46 years. This previous stroke was ischaemic in character with involvement of the brainstem, pons, midbrain and right cerebral peduncle with extension into ...

Electrolyte imbalance triggering relapse of inflammatory neuropathy

We describe a case of a 71 year old female with a fourteen year history of chronic inflammatory demyelinating polyneuropathy (CIDP) and stable monoclonal gammopathy, normally maintained on three&ndash;weekly intravenous immunoglobulin (IVIG) therapy. At her best baseline, she has a normal motor examination and reduced vibration sense only to the ankles. She presented with a four week history of progressive numbness and paresthesiae in all four limbs, reduced balance, a decline in mobility with frequent falls and reduced hand function. The deterioration developed after a week of non&ndash;bloody diarrhoea with night sweats but continued to progress through two courses of her regular IVIG. She also had a past history of breast cancer, hypertension and a duodenal ulcer. On examination she had...<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>

Rhode Island Hospital uncovers pathway linking heartburn and esophageal cancer

(Lifespan) More than 60 million adults in the US have acid reflux, or heartburn, and approximately 10 percent are at risk for developing esophageal cancer, due in part to complications from Barrett's esophagus. But researchers at Rhode Island Hospital discovered a pathway they believe links Barrett's esophagus to the development of esophageal cancer. Their data suggest that blocking this pathway, such as with a proton pump inhibitor (e.g., omeprazole), may prevent the development of esophageal cancer. (Source: EurekAlert! - Social and Behavioral Science)

The outcome of patients with oesophageal eosinophilic infiltration after an eight‚?źweek trial of a proton pump inhibitor

ConclusionsMore than 50% of patients with documented oesophageal eosinophilic infiltration in the EoE range improved when treated with a double‚?źdose PPI trial for 8¬†weeks. These findings support the published guidelines recommending a PPI trial prior to diagnosing EoE, and confirm the existence of an eosinophilic oesophageal infiltrationPPI‚?źresponsive population. (Source: Alimentary Pharmacology and Therapeutics)

Randomised controlled trial: sequential vs. standard triple therapy for Helicobacter pylori infection in Chinese children: a multicentre, open‚?źlabelled study

ConclusionsThe 10‚?źday sequential regimen was significantly more effective than standard 7‚?źday or 10‚?źday triple regimens in eradicating H. pylori infection in Chinese children. (Source: Alimentary Pharmacology and Therapeutics)

Randomised controlled trial: sequential vs. standard triple therapy for Helicobacter pylori infection in Chinese children‚??a multicentre, open‚?źlabelled study

ConclusionsThe 10‚?źday sequential regimen was significantly more effective than standard 7‚?źday or 10‚?źday triple regimens in eradicating H. pylori infection in Chinese children. (Source: Alimentary Pharmacology and Therapeutics)

Twice‚?źdaily dosing of esomeprazole effectively inhibits acid secretion in CYP2C19 rapid metabolisers compared with twice‚?źdaily omeprazole, rabeprazole or lansoprazole

ConclusionsIn intermediate and rapid metabolisers of CYP2C19, PPIs dosed twice daily could attain sufficient acid suppression, while in CYP2C19 RMs, esomeprazole 20 mg twice daily caused the strongest inhibition of the four PPIs. Therefore, esomeprazole may be effective in Japanese population when dosed twice daily. (Source: Alimentary Pharmacology and Therapeutics)<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>

Randomised clinical trial: sodium alginate oral suspension is non‚?źinferior to omeprazole in the treatment of patients with non‚?źerosive gastroesophageal disease

ConclusionThe study showed that sodium alginate was as effective as omeprazole for symptomatic relief in patients with non‚?źerosive reflux disease (Clinicaltrials.gov NCT01338077). (Source: Alimentary Pharmacology and Therapeutics)

Human variation and CYP enzyme contribution in benfuracarb metabolism in human in vitro hepatic models.

Authors: Abass K, Reponen P, Mattila S, Rautio A, Pelkonen O Abstract Human responses to the toxicological effects of chemicals are often complicated by a substantial interindividual variability in toxicokinetics, of which metabolism is often the most important factor. Therefore, we investigated human variation and the contributions of human-CYP isoforms to in vitro metabolism of benfuracarb. The primary metabolic pathways were the initial sulfur oxidation to benfuracarb-sulfoxide and the nitrogen-sulfur bond cleavage to carbofuran (activation). The Km, Vmax, and CLint values of carbofuran production in ten individual hepatic samples varied 7.3-, 3.4-, and 5.4-fold, respectively. CYP2C9 and CYP2C19 catalyzed benfuracarb sulphur oxidation. Carbofuran formation, representing from 79%...

Dose‚?źdependent inhibitory effects of proton pump inhibitors on human osteoclastic and osteoblastic cell activity

Proton pump inhibitors (PPIs), a class of molecules that are used to decrease gastric acid production, might have adverse effects on bone metabolism. The aim of this study was to characterize the concentration‚?źdependent and time‚?źdependent effects of three PPIs (omeprazole, esomeprazole, and lansoprazole) on human osteoclast precursor cells isolated from peripheral blood, and on human mesenchymal stem cells (osteoblast precursors). Cell cultures were characterized for total protein content, apoptosis, and several osteoclastic/osteoblastic features, and also for the involvement of some intracellular signaling pathways. PPIs caused a dose‚?źdependent decrease in cellular density, which correlated with an increase in the apoptosis rate, effects that became statistically significant at conc...

Inhibition of urease activity in the urinary tract pathogen Staphylococcus saprophyticus

This article is protected by copyright. All rights reserved. (Source: Letters in Applied Microbiology)

Diversification of P450 BM3 Substrate Selectivity [Protein Structure and Folding]

Cytochrome P450 monooxygenases (P450s) have enormous potential in the production of oxychemicals, due to their unparalleled regio- and stereoselectivity. The Bacillus megaterium P450 BM3 enzyme is a key model system, with several mutants (many distant from the active site) reported to alter substrate selectivity. It has the highest reported monooxygenase activity of the P450 enzymes, and this catalytic efficiency has inspired protein engineering to enable its exploitation for biotechnologically relevant oxidations with structurally diverse substrates. However, a structural rationale is lacking to explain how these mutations have such effects in the absence of direct change to the active site architecture. Here, we provide the first crystal structures of BM3 mutants in complex with a human ...<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>

Taking over the counter pain relievers safely

For aching joints or a throbbing head, millions of Americans turn to aspirin, ibuprofen (Advil, Motrin), or other nonsteroidal anti-inflammatory drugs (NSAIDs) every day. They are generally safe, but if not used carefully NSAIDs can have a dark side, according to the September 2013 Harvard Women's Health Watch. NSAIDs are widely used because they perform double duty. &ldquo;They not only relieve pain, but they reduce inflammation too,&rdquo; says Dr. Lucy Chen, an assistant professor at Harvard Medical School and attending physician in the anesthesia, critical care, and pain medicine department at Massachusetts General Hospital. NSAIDs work by blocking the production of chemicals in the body that contribute to pain and inflammation. Yet like all medications, NSAIDs have side effects and NS...

Dose‚?źdependent inhibitory effects of Proton pump inhibitors on human osteoclastic and osteoblastic cells activity

This article is protected by copyright. All rights reserved. (Source: FEBS Journal)

Pharmacokinetic drug interactions involving Ginkgo biloba.

Authors: Unger M Abstract Abstract Ginkgo biloba leaf extracts (GLEs) are popular herbal remedies for the treatment of Alzheimer's dementia, tinnitus, vertigo and peripheral arterial disease. As GLEs are taken regularly by older people who are likely to also use multiple other drugs for the treatment of, e.g. hypertension, diabetes, rheumatism or heart failure, potential herb-drug interactions are of interest. Preclinical studies of high doses/concentrations of GLEs of varying quality and standardization hinted at both an inhibition and induction of metabolic enzymes and transporters. However, in humans, positive in vitro-findings could not be replicated in vivo. At maximum recommended doses of 240‚??mg/day, a clinically relevant interaction potential of the standardized GLE EGb 76...

Anti-secretory and cyto-protective effects of peganine hydrochloride isolated from the seeds of Peganum harmala on gastric ulcers

Graphical abstract: Abstract: Gastroprotective mechanism of peganine hydrochloride isolated from Peganum harmala seeds was investigated. Peganine hydrochloride was evaluated against cold restraint (CRU), aspirin (AS), alcohol (AL) and pyloric ligation (PL) induced gastric ulcer models in rats. Potential anti-ulcer activity of peganine was observed against CRU (50.0%), AS (58.5%), AL (89.41%) and PL (62.50%) induced ulcer models. The reference drug omeprazole (10mg/kg, p.o.) showed 77.45% protection against CRU, 49.97% against AS and 69.42% against PL model. Sucralfate, another reference drug (500mg/kg, p.o.) showed 62.50% protection in AL induced ulcer model. Peganine significantly reduced free acidity (33.38%), total acidity (38.09%) and upregulated mucin secretion by 67.91%, respectively...

Therapeutic efficacy of baclofen in refractory gastroesophageal reflux-induced chronic cough.

CONCLUSION: Baclofen is a useful, but suboptimal treatment option for refractory GERC. PMID: 23885151 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)

Banhabaekchulchunma-tang, a traditional herbal formula attenuates absolute ethanol-induced gastric injury by enhancing the antioxidant status

Conclusions: These results indicate that BCT protects the gastric mucosa against ethanol-induced gastric injury by increasing the antioxidant status. We suggest that BCT could be developed as an effective drug for the treatment of gastric injury caused by alcohol intake. (Source: BMC Complementary and Alternative Medicine)

The inhibitory effect of oral contraceptives on CYP2C19 activity is not significant in carriers of the CYP2C19*17 allele.

In conclusion, we showed that OC intake inhibits CYP2C19 in homozygous carriers of the CYP2C19 wildtype but that the inhibition is not statistically significant in the heterozygous and in the homozygous carriers of the CYP2C19*17 allele. This article is protected by copyright. All rights reserved. PMID: 23844835 [PubMed - as supplied by publisher] (Source: Clinical and Experimental Pharmacology and Physiology)

PPIs May Lead to Heart Disease

According to recent research, the drugs that help millions of people control their acid reflux may also cause cardiovascular disease. In human tissue and mouse models, researchers from Houston Methodist Hospital and two other institutions found proton pump inhibitors (PPIs) caused the constriction of blood vessels. If taken regularly, PPIs could lead to a variety of cardiovascular problems over they, the researchers state, including hypertension and a weakened heartburn. In the paper, published in the current issue of Circulation (published by the American Heart Association), the scientists say a broad, large-scale study is needed to determine if PPIs are dangerous. The most commonly taken PPIs are lansoprazole (Prevacid) and omeprazole (Prilosec or Prilosec OTC). "The surprising effec...

Tips for Seniors on the Safe Use of Acid Reflux Medications

As a person gets older, they may be faced with more health conditions that they will need to treat on a regular basis. This includes gastroesophageal reflux disease (GERD). If you are a senior citizen and on various medications, you no doubt know the importance of taking medication safely. Sometimes the difficulty arises when the number of medications, and medical conditions they treat, increases. That's a lot to keep organized at times. These tips on safe use of medications can go a long way in helping you with this part of your health care. Related Information: Antacids Maalox Mylanta Tums Gaviscon Chooz H2 Blockers Axid Pepcid Tagamet Zantac Proton Pump Inhibitors Aciphex Dexilant Nexium Prevacid Prilosec Protonix Tips for Seniors...<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>

Using Acid Reflux Medications Wisely

If you decide to take medication for any medical condition, you should know how to take that medication wisely. Up to half of all those who take medications do not take them as directed. This could be the result of not reading the labels on the prescriptions bottles or on the bottles of the over the counter meds, missing doses, using medication after it's expiration date, etc. In order to make sure you lower your risk of having problems with the medications you take, you can follow the tips in this article on using medications wisely. Related Resources: Antacids Maalox Mylanta Tums Gaviscon Chooz H2 Blockers Axid Pepcid Tagamet Zantac Proton Pump Inhibitors Aciphex Dexilant Nexium Prevacid Prilosec Protonix Using Acid Reflux Medicat...

Assessment of the effect of efflux pump inhibitors on in vitro antimicrobial susceptibility of multidrug-resistant Acinetobacter baumannii

In this study, the effects of several EPIs, including carbonyl cyanide m-chlorophenylhydrazone (CCCP), phenylalanine-arginine ő≤-naphthylamide (PAő≤N) and 1-(1-napthylmethyl)-piperazine (NMP), as well as drugs that may impact bacterial efflux mechanisms, such as omeprazole, verapamil, reserpine and the phenothiazines [prochlorperazine (PCPZ), chlorpromazine (CPZ) and promazine (PMZ)] on the in vitro antimicrobial susceptibility of MDR A. baumannii were assessed. (Source: International Journal of Antimicrobial Agents)

Effects of cytochrome P450 inhibitors and inducers on the metabolism and pharmacokinetics of ospemifene

ConclusionsThe clinical pharmacokinetic findings and in vitro data suggest that CYP3A4 is important for ospemifene metabolism, but other CYP isoforms and metabolic pathways also contribute. Strong CYP3A or CYP2C9 inducers (e.g., rifampicin) would be expected to decrease the exposure to ospemifene. Ospemifene should be used with caution when coadministered with the modest CYP3A inhibitor ketoconazole and should not be coadministered with the potent CYP3A/CYP2C9/CYP2C19 inhibitor fluconazole. The potent CYP2C19 inhibitor omeprazole is unlikely to cause clinically significant changes in ospemifene pharmacokinetics. This article is protected by copyright. All rights reserved. (Source: Biopharmaceutics and Drug Disposition)

A Case of Esophageal Pseudomembranes

Question: A 36-year-old woman presented for evaluation of chronic retrosternal burning. She continued to have daily symptoms despite using omeprazole twice daily. She rarely had liquid regurgitation. Otherwise, she denied dysphagia, odynophagia, and weight loss. Her medical history was notable for migraine headaches and constipation-predominant irritable bowel syndrome. Aside from omeprazole, the only other medication used was an oral contraceptive. (Source: Gastroenterology)<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>

Correlation between virulence gene expression and proton pump inhibitors and ambient pH in C. difficile: Results of an in vitro study.

Authors: Stewart DB, Hegarty JP Abstract Proton pump inhibitors (PPIs) are associated with the development of C. difficile infection in humans. Though it is assumed that PPIs mediate this affect through gastric acid suppression, there has been little investigation into whether PPIs, or ambient pH, might directly affect the expression of C. difficile toxin genes. In the present study, C. difficile ribotypes 001, 027 and 078 obtained from human subjects were grown under anaerobic conditions prepared at pH's of 5, 7.3 and 9. Matched trios were exposed to 100¬ĶM and 200¬ĶM of omeprazole along with PPI untreated controls. Custom designed RT-qPCR hydrolysis probes were used to assess C. difficile gene expression for toxins A (tcdA), B (tcdB) and binary toxin (cdtB), as well as their posi...

A double-blind placebo-controlled randomized trial on probiotics in small bowel bacterial overgrowth in children treated with omeprazole.

CONCLUSIONS: Since symptoms suggesting SBBO developed in 26% of PPI-treated children, and since the glucose breath test was abnormal in 72% of these, this side-effect should be more frequently considered. The probiotic tested did not decrease the risk to develop SBBO. PMID: 23796359 [PubMed - as supplied by publisher] (Source: Jornal de Pediatria)

Effect of Repeated Wuniu Early Tea Administration on the CYP450 Activity Using a Cocktail Method

RA Xu, ZS Xu, GY Lin, LF Hu, XQ Wang, JS MaIndian Journal of Pharmaceutical Sciences 2013 75(1):94-98Wuniu early tea (Camellia sinensis) is an important beverage consumed in China. Up to date, a lot of methods for identifying and chemical analysing have been done. However, there is no report on the effects of Wuniu early tea on cytochrome P450 isozymes. Therefore, the present objective of our study was to evaluate the potential effects of Wuniu early tea on cytochrome P450 isozymes P2C9, P1A2, P2C19 and P2B6 in rats with a cocktail approach including, matching probe drugs of tolbutamide, phenacetin, omeprazole and bupropion. These four probe drugs were simultaneously administered to rats after repeated Wuniu early tea administration. The pharmacokinetics of the probes in the plasma was sim...

Pharmacokinetic drug interaction profile of omeprazole with adverse consequences and clinical risk management.

CONCLUSION: Despite the fact that omeprazole is one of the most widely prescribed drugs internationally, clinical professionals should enhance clinical risk management on adverse DDIs associated with omeprazole and ensure safe combination use of omeprazole by rationally prescribing alternatives, checking the appropriateness of physician orders before dispensing, and performing therapeutic drug monitoring. PMID: 23745048 [PubMed] (Source: Clinical Breast Cancer)

Omeprazole enhances the colonic expression of the Mg(2+) transporter TRPM6.

Authors: Lameris AL, Hess MW, van Kruijsbergen I, Hoenderop JG, Bindels RJ Abstract Proton pump inhibitors (PPIs) are potent blockers of gastric acid secretion, used by millions of patients suffering from gastric acid-related complaints. Although PPIs have an excellent safety profile, an increasing number of case reports describe patients with severe hypomagnesemia due to long-term PPI use. As there is no evidence of a renal Mg(2+) leak, PPI-induced hypomagnesemia is hypothesized to result from intestinal malabsorption of Mg(2+). The aim of this study was to investigate the effect of PPIs on Mg(2+) homeostasis in an in vivo mouse model. To this end, C57BL/6J mice were treated with omeprazole, under normal and low dietary Mg(2+) availability. Omeprazole did not induce changes in ser...<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>

The H(+)/K(+)-ATPase inhibitory activities of Trametenolic acid B from Trametes lactinea (Berk.) Pat, and its effects on gastric cancer cells.

This study was performed to investigate the effects of TAB on H(+)/K(+)-ATPase and gastric cancer. The H(+)/K(+)-ATPase inhibitory activity was determined by gastric parietal cells. Compared to the normal control group, TAB (10, 20, 40 and 80őľg/mL) inhibited the H(+)/K(+)-ATPase activity by 15.97, 16.96, 24.86 and 16.25%, respectively. In the study, 36 Kunming mice were randomly divided into six groups: control, model, TAB-L (TAB, 5mg/kg/day, i.g.), TAB-M (TAB, 20mg/kg/day, i.g ), TAB-H (TAB, 40mg/kg/day, i.g.) and omeprazole (OL, 10mg/kg/day, i.g.). All mice except control group were administrated with anhydrous alcohol (5.0mL/kg, i.g.) for induced gastric-ulcer in the 1hour after 5th day. At the same time, the control mice were given the same volume of physiological saline. After 4hours...

Prevalence of drug interactions in intensive care units in Brazil

CONCLUSION: In this sample, moderate and severe drug interactions were more prevalent. In light of these findings, all actions of health professionals who provide care to these patients must be integrated in order to identify and prevent possible drug events. (Source: Acta Paulista de Enfermagem)

Trends of Second‚?źLine Eradication Therapy for Helicobacter pylori in Japan: A Multicenter Study in the Tokyo Metropolitan Area

ConclusionsFrom 2007 to 2011, there were no significant trends in the second‚?źline eradication rates and the rates remained consistently high. From the viewpoint of high prevalence of CAM resistance in Japan, triple therapy with PPI, AMPC and MNZ may be a better strategy for first‚?źline therapy compared to triple therapy with PPI, AMPC and CAM. (Source: Helicobacter)

Thrombocytopenia as a side effect of pantoprazole.

In conclusion, PPIs should be among the differential diagnosis of thrombocytopenia. PMID: 24226727 [PubMed - in process] (Source: The Turkish Journal of Gastroenterology)

Acid buffering effects of aqueous leaf extract of Ocimum gratissimum L. in the rabbit stomach.

Conclusion: The results indicate that the anti-secretory activity of Ocimum gratissimum may be the anti-ulcer mechanism of this plant. PMID: 24226712 [PubMed - in process] (Source: The Turkish Journal of Gastroenterology)<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>

Indirect comparison of randomised controlled trials: comparative efficacy of dexlansoprazole vs. esomeprazole in the treatment of gastro‚?źoesophageal reflux disease

ConclusionsAdjusted indirect comparisons based on currently available RCT data suggested significantly better treatment effect in symptom control of heartburn in patients with NERD for dexlansoprazole against esomeprazole. No statistically significant differences were found in other EO outcomes. However, these study findings need to be interpreted with caution due to small number of studies and other limitations. (Source: Alimentary Pharmacology and Therapeutics)

Prescribe Escitalopram Instead of Citalopram

I would like to respond to the recently published review entitled ‚??Citalopram, QTc Interval Prolongation, and Torsade de Pointes. How Should We Apply the Recent FDA Ruling?‚?Ě A revised Drug Safety Communication on Celexa was posted on the US Food and Drug Administration (FDA) Web site on March 28, 2012, which included data obtained from randomized double-blind placebo-controlled cross-over studies of the effects of citalopram and escitalopram on the corrected QT [QTc] intervals in adults. Citalopram 20 mg caused an average QTc prolongation of 8.5 ms (95% confidence interval [CI], 6.2-10.8 ms), while the therapeutically equivalent dose of escitalopram (10 mg) prolonged QTc by an average of only 4.5 ms (95% CI, 2.5-6.4 ms). Similarly, citalopram 60 mg prolonged QTc by 18.5 ms (95% CI, 16....

The chiral bioconversion and preclinical pharmacokinetic analysis of (R)-(+)-rabeprazole in beagle dogs by HPLC and HPLC-MS/MS.

Authors: Gao YH, Xu JX, Su ZX, Song L, Lou HX Abstract In order to accurately investigate the preclinical pharmacokinetics of (R)-(+)-rabeprazole sodium injection, a reliable high-performance liquid chromatography (HPLC) method was developed using a Chiral-AGP column to prove that there is no chiral bioconversion of (R)-(+)-rabeprazole to (S)-(-)-rabeprazole in beagle dogs after single intravenous administration of (R)-(+)-rabeprazole sodium injection. An HPLC-tandem mass spectrometry (HPLC-MS/MS) method for analysis of (R)-(+)-rabeprazole was developed and validated, and used to acquire the pharmacokinetic parameters in beagle dogs. (R)-(+)-Rabeprazole and internal standard omeprazole were extracted from plasma samples by protein precipitation and separated on a C18 column using m...

Tips for Seniors on the Safe Use of Acid Reflux Medications

As a person gets older, they may be faced with more health conditions that they will need to treat on a regular basis. This includes gastroesophageal reflux disease (GERD). If you are a senior citizen and on various medications, you no doubt know the importance of taking medication safely. Sometimes the difficulty arises when the number of medications, and medical conditions they treat, increases. That's a lot to keep organized at times. These tips on safe use of medications can go a long way in helping you with this part of your health care. Related Information: Antacids Maalox Mylanta Tums Gaviscon Chooz H2 Blockers Axid Pepcid Tagamet Zantac Proton Pump Inhibitors Aciphex Dexilant Nexium Prevacid Prilosec Protonix Tips for Seniors...

Intragastric acidity and omeprazole exposure during dosing with either PA32540 (enteric‚?źcoated aspirin 325¬†mg + immediate‚?źrelease omeprazole 40¬†mg) or enteric‚?źcoated aspirin 325¬†mg + enteric‚?źcoated omeprazole 40¬†mg ‚?? a randomised, phase 1, crossover study

ConclusionTotal exposure to omeprazole from PA32540 was 57% of that from EC‚?źomeprazole for the same dose amount (40¬†mg), while absolute difference in 24‚?źh acid control was 7%. Omeprazole exposure and pH control with PA32540 appear similar to EC‚?źomeprazole 20¬†mg. (Source: Alimentary Pharmacology and Therapeutics)<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>

Therapeutic substitution post‚?źpatent expiry: the cases of ace inhibitors and proton pump inhibitors

This paper examines whether there is a switch in total (originator and generic) consumption after generic entry from molecules that face generic competition towards other molecules of the same class, which are still in‚?źpatent. Data from six European countries for the time period 1991 to 2006 are used to study the cases of angiotensin‚?źconverting enzyme inhibitors and proton pump inhibitors. Empirical evidence shows that patent expiry of captopril and enalapril led to a switch in total (off‚?źpatent originator and generic) consumption towards other in‚?źpatent angiotensin‚?źconverting enzyme inhibitors, whereas patent expiry of omeprazole led to a switch in consumption towards other proton pump inhibitors. This phenomenon makes generic policies ineffective and results in an increase in p...

Clinical Perspective on Drug‚??Drug Interactions with the Non-nucleoside Reverse Transcriptase Inhibitor Rilpivirine.

Authors: Crauwels H, van Heeswijk RP, Stevens M, Buelens A, Vanveggel S, Boven K, Hoetelmans R Abstract Rilpivirine (TMC278) is a non-nucleoside reverse transcriptase inhibitor approved in combination with other antiretrovirals for the treatment of HIV‚??1 infection in treatment‚??naive adults (Edurant¬ģ 25¬†mg once daily; Complera¬ģ [USA]/Eviplera¬ģ [EU] once daily single‚??tablet regimen). Rilpivirine should be administered with a meal to optimize bioavailability. Its solubility is pH dependent. Rilpivirine is primarily excreted via the feces with negligible renal elimination. Rilpivirine is predominantly metabolized by cytochrome P450 3A4. There is no clinically relevant effect of age, gender, bodyweight, race, estimated glomerular filtration rate, or hepatitis B/C coinfection s...

Dynamic esophageal stents

Summary Esophageal stenting represents a new strategy in the treatment of resistant or recurrent stenosis that obviates the need for multiple dilations. Our custom dynamic stent (DS) improves esophageal motility unlike the widespread self‚?źexpandable plastic or metallic esophageal stents. The DS allows food and secretions to pass in the space between the esophageal wall and the stent wall. This contrasts with the other types of stent, in which food passes into the stent that presses into the esophageal wall. Until the stent patent is complete, we use slices of silicon drains overlapped with each other to fashion the stent to the desired length and diameter (7‚?ź, 9‚?ź, or 12.7‚?źmm external diameter). It is built coaxially on a nasogastric tube that guarantees the correct position. The tw...

Lack of association between proton pump inhibitors and adverse events in patients taking clopidogrel and aspirin

Commentary on Douglas IJ, Evans SJ, Hingorani AD, et al.. Clopidogrel and interaction with proton pump inhibitors: comparison between cohort and within person study designs. BMJ 2012;345:e4388 Context Clopidogrel inhibits the P2Y12 platelet receptor and is used in patients with acute coronary syndromes or ischaemic stroke to prevent recurrent vascular events. Proton pump inhibitors (PPIs), however, have been shown to reduce the pharmacodynamic effect of clopidogrel upon platelet inhibition, and have been linked in retrospective studies to a higher rate of ischaemic outcomes in patients taking clopidogrel. Methods A total of 24&nbsp;471 patients in the General Practice Research Database in the UK (beginning in 2003) concurrently prescribed aspirin and clopidogrel were included. There were 1...

Preventive effect of irsogladine or omeprazole on non-steroidal anti-inflammatory drug-induced esophagitis, peptic ulcers, and small intestinal lesions in humans, a prospective randomized controlled study

Irsogladine provides better protection against NSAID-induced small-intestinal injuries than the PPI Omeprazole in healthy subjects assessed by biochemical approaches and capsule endoscopy, suggesting it could provide protection&nbsp;against NSAID-induced injuries to the entire digestive tract (Source: BMC Gastroenterology)<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>

Lack of a clinically significant drug-drug interaction in healthy volunteers between the HCV protease inhibitor boceprevir and the proton pump inhibitor omeprazole

Conclusions Omeprazole did not have a clinically significant effect on boceprevir exposure, and boceprevir did not affect omeprazole exposure. (Source: Journal of Antimicrobial Chemotherapy)

Pharmacists' adoption into practice of newly reclassified medicines from diverse therapeutic areas in Scotland: A quantitative study of factors associated with decision-making

Abstract: Background: In the UK, over 90 medicines that were previously available only through prescription have been reclassified to allow over-the-counter (OTC) availability via pharmacies. Pharmacists are personally responsible for undertaking or supervising the sales and supplies of these OTC ‚??pharmacy only‚?? (P) medicines. Reclassification facilitates pharmacy management of a wide range of conditions.Objective: This research aimed to evaluate Scottish community pharmacists' perspectives of newly reclassified ‚??P‚?? medicines from diverse therapeutic areas and to identify factors associated with their adoption into practice of these medicines.Methods: A cross-sectional postal survey of all community pharmacies in Scotland (N¬†=¬†1138) was undertaken. The questionnaire was mailed to...

A retrospective analysis of any trends in magnesium level for patients on omeprazole 10 mg/5 ml oral suspension from January to June 2012 (inclusive) in response to the MHRA Drug Safety Update April 2012

Conclusions The MHRA report published in April 2012 highlights the need to assess for hypomagnesaemia in patients using a PPI especially following long term use. This study highlights that a trend in a paediatric population for hypomagnesaemia may also be seen but only 50% of patients assessed have had their magnesium levels measures which suggests that prescribers do not monitor magnesium levels for these patients. Further study will be needed and the data should be presented to paediatric prescribers highlighting the extent of hypomagnesaemia in this group of patients. We should bear in mind the clinical risk that this may lead to such as other electrolyte imbalances2 and Torsade de pointes2 if not monitored. (Source: Archives of Disease in Childhood)

Efavirenz-mediated induction of omeprazole metabolism is CYP2C19 genotype dependent

Authors: V Michaud, Y Kreutz, T Skaar, E Ogburn, N Thong, D A Flockhart & Z Desta (Source: The Pharmacogenomics Journal)

Omeprazole blocks eotaxin-3 expression by oesophageal squamous cells from patients with eosinophilic oesophagitis and GORD

Conclusion Oesophageal squamous cells from GORD and EoE patients express similar levels of eotaxin-3 when stimulated by Th2 cytokines, and omeprazole blocks that eotaxin-3 expression. These findings suggest that PPIs might have eosinophil-reducing effects independent of effects on acid reflux and that response to PPIs might not distinguish EoE from GORD. (Source: Gut)<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>

Platelet Inhibitory Effect of Clopidogrel in Patients Treated With Omeprazole, Pantoprazole, and Famotidine: A Prospective, Randomized, Crossover Study

ConclusionsAfter eliminating the effects of interindividual variability in clopidogrel metabolism, omeprazole therapy was associated with substantially more HPR than famotidine or pantoprazole. (Source: Clinical Cardiology)

What Are Proton Pump Inhibitors?

Proton pump inhibitors (PPIs) are a group of medications that have been used to decrease the amount of acid in the stomach and intestines. Doctors prescribe PPIs to treat people with GERD, ulcers in the stomach or intestine, or other digestive disorders where the production of stomach acid needs to be controlled. Read more about what proton pump inhibitors are and what they do. Types of PPIs: Aciphex Dexilant Nexium Prevacid Prilosec Protonix Related Resources: GERD Erosive Esophagitis Zollinger-Ellison syndrome Peptic Ulcers What Are Proton Pump Inhibitors? originally appeared on About.com Heartburn / GERD on Monday, April 29th, 2013 at 22:00:51.Permalink | Comment | Email this (Source: About Heartburn / Acid Reflux)

Omeprazole improves the anti‚?źobesity and antidiabetic effects of exendin‚?ź4 in db/db mice (Ś••Áĺ?ś??Ś??ś?ĻŚ??Ś?ĺś∂≤Áī†‚?ź4 ŚĮĻdb/dbŚįŹťľ†Á??Ś?ŹŤ?•šł?ť?ćÁ≥?šĹ?Á?®)*

Symptomatic bacterial contamination of an intragastric balloon

A 45-year-old woman had an intragastric balloon placed endoscopically for metabolic syndrome and obesity (body mass index = 37.42 kg/m2). She was being maintained on omeprazole daily. Under endoscopic view, the balloon was positioned in the stomach and inflated with 650 mL of 0.9% NaCl mixed with 20 mL of methylene blue solution. After 4 months, the patient had lost 22 kg but began to report intense nausea, vomiting, abdominal distention, and abdominal pain. An abdominal plain film showed a radiolucent and elongated structure in the upper abdomen (A). Endoscopy revealed an enlarged balloon, and the solution inside the balloon was collected during its removal by puncture. Inspection of the balloon after withdrawal showed its surface to be irregular with microbubbles and what appeared to ...

Prevalence of Helicobacter pylori infection and the effect of its eradication on symptoms of functional dyspepsia in Kashmir, India

ConclusionThere is high H.‚??pylori positivity rate in patients of functional dyspepsia. The eradication of H.‚??pylori does not resolve the symptoms despite healing of gastritis. (Source: Journal of Gastroenterology and Hepatology)<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>

Normal and polar-organic-phase high-performance liquid chromatographic enantioresolution of omeprazole, rabeprazole, lansoprazole and pantoprazole using monochloro-methylated cellulose-based chiral stationary phase and determination of dexrabeprazole.

Authors: Dixit S, Dubey R, Bhushan R Abstract Enantioresolution of four anti-ulcer drugs (chiral sulfoxides), namely, omeprazole, rabeprazole, lansoprazole and pantoprazole, was carried out by high-performance liquid chromatography using a polysaccharide-based chiral stationary phase consisting of monochloromethylated cellulose (Lux cellulose-2) under normal and polar-organic-phase conditions with ultraviolet detection at 285‚??nm. The method was validated for linearity, accuracy, precision, robustness and limit of detection. The optimized enantioresolution method was compared for both the elution modes. The optimized method was further utilized to check the enantiomeric purity of dexrabeprazole. Copyright ¬© 2013 John Wiley & Sons, Ltd. PMID: 23616104 [PubMed - as supplied...

Gastroprotective effects of Corchorus olitorius leaf extract against ethanol‚?źinduced gastric mucosal hemorrhagic lesions in rats

ConclusionsOur study reports the gastroprotective property of an ethanolic extract of C. olitorius against ethanol‚?źinduced gastric mucosal hemorrhagic lesions in rats. (Source: Journal of Gastroenterology and Hepatology)

Statin-Associated Polymyositis Following Omeprazole Treatment.

Authors: Kanth R, Shah MS, Flores RM Abstract Statins are an extensively used class of drugs, and myopathy is an uncommon, but well-described side effect of statin therapy. Inflammatory myopathies, including polymyositis, dermatomyositis, and necrotizing autoimmune myopathy, are even rarer, but debilitating, side effects of statin therapy that are characterized by the persistence of symptoms even after discontinuation of the drug. It is important to differentiate statin-associated inflammatory myopathies from other self-limited myopathies, as the disease often requires multiple immunosuppressive therapies. Drug interactions increase the risk of statin-associated toxic myopathy, but no risk factors for statin-associated inflammatory myopathies have been established. Here we describe...

Optimized Nonbismuth Quadruple Therapies Cure Most Patients With Helicobacter pylori Infection in Populations With High Rates of Antibiotic Resistance

Conclusions: Optimized nonbismuth quadruple hybrid and concomitant therapies cured more than 90% of patients with H pylori infections in areas of high clarithromycin and metronidazole resistance. ClinicalTrials.gov number NCT01464060. (Source: Gastroenterology)

Proton pump inhibitors in pediatrics : mechanism of action, pharmacokinetics, pharmacogenetics, and pharmacodynamics.

Authors: Ward RM, Kearns GL Abstract Proton pump inhibitors (PPIs) have become some of the most frequently prescribed medications for treatment of adults and children. Their effectiveness for treatment of peptic conditions in the pediatric population, including gastric ulcers, gastroesophageal reflux disease (GERD), and Helicobacter pylori infections has been established for children older than 1 year. Studies of the preverbal population of neonates and infants have identified doses that inhibit acid production, but the effectiveness of PPIs in the treatment of GERD has not been established except for the recent approval of esomeprazole treatment of erosive esophagitis in infants. Reasons that have been proposed for this are complex, ranging from GERD not occurring in this populati...<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>

Using Acid Reflux Medications Wisely

If you decide to take medication for any medical condition, you should know how to take that medication wisely. Up to half of all those who take medications do not take them as directed. This could be the result of not reading the labels on the prescriptions bottles or on the bottles of the over the counter meds, missing doses, using medication after it's expiration date, etc. In order to make sure you lower your risk of having problems with the medications you take, you can follow the tips in this article on using medications wisely. Related Resources: Antacids Maalox Mylanta Tums Gaviscon Chooz H2 Blockers Axid Pepcid Tagamet Zantac Proton Pump Inhibitors Aciphex Dexilant Nexium Prevacid Prilosec Protonix Using Acid Reflux Medicat...

Gastroesophageal Reflux Disease and Its Association With Bronchiolitis Obliterans Syndrome in Allogeneic Hematopoietic Stem Cell Transplant Recipients.

CONCLUSIONS: Our study shows a significant association between bronchiolitis obliterans syndrome and gastroesophageal reflux disease in postallogeneic hematopoietic stem cell transplant patients. Use of omeprazole may have a disease-stabilizing effect in short-term follow-up. PMID: 23530912 [PubMed - as supplied by publisher] (Source: Experimental and Clinical Transplantation : official journal of the Middle East Society for Organ Transplantation)

Extraction of the volatile oil from Carum carvi of Tunisia and Lithuania by supercritical carbon dioxide: chemical composition and antiulcerogenic activity.

This study investigates whether the essential oil prepared from Carum carvi seeds exhibits antiulcerogenic activity. Its volatile oil was obtained by supercritical fluid extraction (SFE) and by hydrodistillation. The essential oils were analysed by GC-MS to monitor their composition. The chemical analysis revealed that the essential oils extracted under SFE conditions had high carvone and limonene contents. The antiulcerogenic activity was evaluated by the HCl/ethanol method, which causes injury to the gastric mucosa. Three treated groups received the essential oil (100-300 mg/kg). The reference group received omeprazole (30 mg/kg) and the control group received NaCl. After 30 min, all groups were treated with HCl/EtOH for gastric ulcer induction. The results show C. carvi essential oil...

Miocamycin‚?źContaining Triple Therapy for H. pylori Infection

ConclusionsMiocamycin appears to be a valid alternative for clarithromycin for H.¬†pylori eradication. Head‚?źto‚?źhead studies will be needed to ascertain whether it is superior. (Source: Helicobacter)

Anti-secretory and cyto-protective effects of chebulinic acid isolated from the fruits of Terminalia chebula on gastric ulcers

Graphical abstract: Abstract: In continuation of our drug discovery program on Indian medicinal plants, the gastro protective mechanism of chebulinic acid isolated from Terminalia chebula fruit was investigated. Chebulinic acid was evaluated against cold restraint (CRU), aspirin (AS), alcohol (AL) and pyloric ligation (PL) induced gastric ulcer models in rats. Potential anti-ulcer activity of chebulinic acid was observed against CRU (62.9%), AS (55.3%), AL (80.67%) and PL (66.63%) induced ulcer models. The reference drug omeprazole (10mg/kg, p.o.) showed 77.73% protection against CRU, 58.30% against AS and 70.80% against PL model. Sucralfate, another reference drug (500mg/kg, p.o.) showed 65.67% protection in AL induced ulcer model. Chebulinic acid significantly reduced free acidity (48.82...<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>

Veterans Diagnosed With Reflux Issues Often Start On High Doses Of Drugs, Rarely Stop Therapy

U.S. veterans diagnosed with gastroesophageal reflux disease (GERD) are frequently prescribed doses of proton pump inhibitors (PPIs), such as omeprazole (commonly known by brand names such as Prilosec), that are much higher than recommended --- and they are kept on the drug far too long, according to a new Northwestern Medicine¬ģ study. PPIs are among the most widely used drugs in the nation, resulting in more than $11 billion in annual direct health care costs in the U.S... (Source: Health News from Medical News Today)

Heartburn Meds May Often Be Taken for Too Long, at Too-High Doses

Study of U.S. veterans found many stay on drugs such as Prilosec for months, years without reevaluation Source: HealthDay Related MedlinePlus Pages: GERD, Medicines, Veterans and Military Health (Source: MedlinePlus Health News)

Prevalence of Helicobacter pylori infection and the effect of its eradication on symptoms of functional dyspepsia in Kashmir, India.

Conclusion: There is high H Pylori positivity rate in patients of functional dyspepsia. The eradication of H Pylori does not resolve the symptoms, despite healing of gastritis. (Source: Journal of Gastroenterology and Hepatology)

Expert position paper on use of proton pump inhibitors in patients with cardiovascular disease and antithrombotic therapy

Source: Eur Heart J Area: News The European Society of Cardiology NSTEMI and STEMI guidelines and an ACCF/ACG/AHA consensus document recommend treatment with proton pump inhibitors (PPIs) in patients treated with dual antiplatelet treatment (DAPT) during the initial phase of an acute coronary syndrome (ACS), particularly in patients with a history of GI bleeding or peptic ulcer. Several studies have raised concerns that many PPIs, especially omeprazole, might diminish the antiplatelet effects of clopidogrel, most likely through inhibition of CYP2C19 and, consequently, the conversion of clopidogrel into its active metabolite. &#160; This position paper reviews the pharmacokinetic background of the interactions between these drugs, and their consequences on clinical outcomes, and presen...

Effect of repeated doses of netazepide, a gastrin receptor antagonist, omeprazole and placebo on 24‚?źh gastric acidity and gastrin in healthy subjects

ConclusionAlthough repeated doses of netazepide led to tolerance to its effect on pH, the accompanying increase in plasma gastrin is consistent with continued inhibition of acid secretion, via gastrin receptor antagonism and gene up‚?źregulation. (Source: British Journal of Clinical Pharmacology)<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>

Prescription problems for vets on reflux drug

(Northwestern University) US veterans diagnosed with gastroesophageal reflux disease are frequently prescribed doses of proton pump inhibitors, such as omeprazole (commonly known by brand names such as Prilosec), that are much higher than recommended -- and they are kept on the drug far too long, according to a new Northwestern Medicine study. (Source: EurekAlert! - Medicine and Health)

Clopidogrel Pharmacokinetics and Pharmacodynamics Vary Widely Despite Exclusion or Control of Polymorphisms ( CYP2C19 , ABCB1 , PON1 ), Noncompliance, Diet, Smoking, Co-Medications (Including Proton Pump Inhibitors), and Pre-Existent Variability in Platelet Function

ConclusionsClopidogrel pharmacokinetics and pharmacodynamics vary widely despite rigorous exclusion or control of known disease, polymorphisms (CYP2C19, CYP3A5, ABCB1, PON1), noncompliance, co-medications, diet, smoking, alcohol, demographics, and pre-treatment platelet hyperreactivity. Thus, as yet unidentified factors contribute to high on-treatment platelet reactivity with its known increased risk of major adverse cardiovascular events. (A Study of the Effects of Multiple Doses of Dexiansoprazole, Lansoprazole, Omeprazole or Esomeprazole on the Pharmacokinetics and Pharmacodynamics of Clopidogrel in Healthy Participants: NCT00942175) (Source: Journal of the American College of Cardiology: Cardiovascular Interventions)

Esomeprazole/omeprazole/tacrolimus interaction: Various toxicities: case report

(Source: Reactions)

TOPCARE OMEPRAZOLE (Omeprazole) Tablet, Delayed Release [Topco Associates LLC]

Updated Date: Feb 14, 2013 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

HEALTH MART OMEPRAZOLE (Omeprazole) Tablet, Delayed Release [McKesson]

Updated Date: Feb 14, 2013 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>

Gastrointestinal Tolerability Events in Relapsing-Remitting Multiple Sclerosis (RRMS) Patients Treated with Oral BG-12 (Dimethyl Fumarate) in DEFINE and CONFIRM (P01.164)

CONCLUSIONS: The incidence of GI AEs was highest in the first 3 months of treatment (most commonly abdominal/upper abdominal pain and nausea/vomiting, and diarrhea). Most events were mild-to-moderate in severity and resolved within the first 3 months while few GI events resulted in treatment discontinuation. Further studies are needed to evaluate the efficacy of individual management strategies.Supported by: Biogen Idec Inc.Disclosure: Dr. Selmaj has received personal compensation for activities with Biogen Idec, Genzyme, Ono Pharmaceutical, Novartis, Bayer, Hoffmann LaRoche, Merck, Serono and Synthon. Dr. Gold has received personal compensation for activities with Bayer HealthCare, Biogen Idec, Merck Serono, Novartis, and Teva Neuroscience. Dr. Gold has received personal compensation in a...

Mucosal healing effect of mesalazine granules in naproxen-induced small bowel enteropathy.

CONCLUSION: According to the small bowel CE evaluation mesalazine granules significantly attenuated mucosal injuries in patients with moderate-to-severe enteropathies induced by naproxen. PMID: 23431027 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)

Quadruple therapy for eradication of Helicobacter pylori.

CONCLUSION: Rabeprazole, amoxicillin, levofloxacin and furazolidone quadruple therapy is a safe method for the eradication of H. pylori with high efficacy and good tolerability. PMID: 23429422 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)

HEALTHY ACCENTS OMEPRAZOLE (Omeprazole) Tablet, Delayed Release [DZA Brands LLC]

Updated Date: Feb 13, 2013 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

What is the optimum prophylaxis against gastrointestinal haemorrhage for patients undergoing adult cardiac surgery: histamine receptor antagonists, or proton-pump inhibitors?

A best evidence topic was written according to a structured protocol. The question addressed was what is the optimum prophylaxis against gastrointestinal haemorrhage for patients undergoing adult cardiac surgery: histamine receptor antagonists (H2RA) or proton-pump inhibitors? A total of 201 papers were found; of which, 8 represented the best evidence. The authors, date, journal, study type, population, main outcome measures and results were tabulated. Only one randomized controlled trial (RCT) with relevant clinical outcomes was identified. The rest of the studies consisted of five prospective studies and two retrospective studies. In the RCT, there were no reported cases of gastrointestinal haemorrhage in the proton-pump inhibitor cohort, whereas 4 patients taking H2RA developed it. The ...<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>

UP AND UP OMEPRAZOLE (Omeprazole) Tablet, Delayed Release [Target Corporation]

Updated Date: Feb 8, 2013 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

DG HEALTH OMEPRAZOLE (Omeprazole) Tablet, Delayed Release [Dolgencorp, LLC]

Updated Date: Feb 8, 2013 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

ZEGERID OTC (Omeprazole And Sodium Bicarbonate) Capsule [MSD Consumer Care, Inc.]

Updated Date: Feb 8, 2013 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

SMART SENSE OMEPRAZOLE (Omeprazole) Tablet, Delayed Release [Kmart Corporation]

Updated Date: Feb 8, 2013 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

EQUALINE OMEPRAZOLE (Omeprazole) Tablet, Delayed Release [Supervalu Inc]

Updated Date: Feb 8, 2013 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>

SUNMARK OMEPRAZOLE (Omeprazole) Tablet, Delayed Release [McKesson]

Updated Date: Feb 8, 2013 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

OMEPRAZOLE (Omeprazole) Capsule, Delayed Release [Lake Erie Medical DBA Quality Care Products LLC]

Updated Date: Feb 7, 2013 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

Clopidogrel, CYP2C19, and a Black Box.

Authors: Ford NF, Taubert D Abstract It has been presumed that CYP2C19 has a major role in the metabolism of clopidogrel. This presumption has been based on in vitro drug metabolism studies using microsomes from baculovirus infected insect cells (BD-Supersomes‚?Ę). If clopidogrel were primarily a CYP2C19 substrate, a drug/drug interaction with CYP2C19 inhibitors, such as proton pump inhibitors (PPIs), for example, omeprazole and lansoprazole would be anticipated. Several ex vivo studies, using ADP stimulated platelet aggregation, suggested that there was such an interaction. The data from these studies served as a basis for FDA to provide a "Black Box" warning for the clopidogrel label in March of 2010. However, a prospective clinical study, COGENT, and several large meta-analyses ...

Incidence of bacteremia following upper gastrointestinal endoscopy and biopsy in healthy dogs before, during, and after treatment with omeprazole.

Conclusions and Clinical Relevance-Routine gastrointestinal endoscopy with biopsy in healthy dogs did not result in a detectable bacteremia in most dogs. Treatment with the gastric acid-suppressing medication omeprazole did not affect the incidence of bacteremia as detected via standard techniques. PMID: 23363348 [PubMed - in process] (Source: American Journal of Veterinary Research)

The Effects of Multistrain Probiotic Compound on Bismuth‚?źContaining Quadruple Therapy for Helicobacter pylori Infection: A Randomized Placebo‚?źControlled Triple‚?źBlind Study

ConclusionsIn overall, our studied multistrain probiotic compound has not beneficial effects in the treatment of H. pylori infection. It might be related to the low dosage of our probiotic regimen and/or high frequency of upper gastrointestinal adverse effects which in turn could decrease the eradication efficacy. (Source: Helicobacter)<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>

Down‚?źregulated lysosomal processing improved pegylated lipopolyplex‚?źmediated gene transfection

ConclusionsOmeprazole might be used as a helper to improve gene transfection efficiencies of some PEGylated gene delivery vectors in vitro and in vivo. This article is protected by copyright. All rights reserved. (Source: The Journal of Gene Medicine)

Reversible stroke-like symptoms with severe hyponatremia.

Authors: Holloman LN, Kolade VO, Zapko DR, Youngblood LB Abstract A 65-year-old Caucasian female was brought to the Emergency Department by her husband for increasing generalized weakness, slurred speech and new-onset facial droop. A non-contrast computerized tomography scan of her brain was negative; however, she was found to have a sodium level of 99 mmol/L. Her daily medications included hydrochlorothiazide, omeprazole and irbesartan. On physical examination, she was found to have slight confusion, lethargy, slowed speech, generalized weakness and left-sided facial droop but no other focal deficits. Over the course of her hospital stay, the patient's sodium levels were corrected slowly On the fifth day of admission, the majority of the patient's neurologic symptoms had resolved,...

Azithromycin based triple therapy versus standard clarithromycin based triple therapy in eradication of Helicobacter pylori infection in Iran: a randomized controlled clinical trial.

Conclusion: The results of this study suggest that azithromycin, amoxicillin, and omeprazole at best is as effective as clarithromycin, amoxicillin, and omeprazole; and this new therapy could be considered as an alternative choice for Helicobacter pylori eradication, especially in geographic areas with lower economic status. PMID: 23794338 [PubMed - in process] (Source: The Turkish Journal of Gastroenterology)

Clopidogrel Pharmacokinetics and Pharmacodynamics Vary Widely Despite Exclusion or Control of Polymorphisms (CYP2C19, ABCB1, PON1), Noncompliance, Diet, Smoking, Co-Medications (Including Proton Pump Inhibitors), and Pre-Existent Variability in Platelet Function

Conclusions: Clopidogrel pharmacokinetics and pharmacodynamics vary widely despite rigorous exclusion or control of known disease, polymorphisms (CYP2C19, CYP3A5, ABCB1, PON1), noncompliance, co-medications, diet, smoking, alcohol, demographics, and pre-treatment platelet hyperreactivity. Thus, as yet unidentified factors contribute to high on-treatment platelet reactivity with its known increased risk of major adverse cardiovascular events. (A Study of the Effects of Multiple Doses of Dexiansoprazole, Lansoprazole, Omeprazole or Esomeprazole on the Pharmacokinetics and Pharmacodynamics of Clopidogrel in Healthy Participants: NCT00942175) (Source: Journal of the American College of Cardiology)

Omeprazole: Granulocytopenia: case report

(Source: Reactions)<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>

d'Oliveira & Associates Now Offers a No Win - No Fee Promise...

The law firm of d‚??Oliveira & Associates is working with some of the leading Prilosec lawyers in the country handling Prilosec cases and want the public to know that they offer a ‚??No Win No Fee...(PRWeb January 18, 2013)Read the full story at http://www.prweb.com/releases/2013/1/prweb10334594.htm (Source: PRWeb: Medical Pharmaceuticals)

KIRKLAND SIGNATURE OMEPRAZOLE (Omeprazole) Tablet, Delayed Release [Costco Wholesale Company]

Updated Date: Jan 15, 2013 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

Omeprazole/tigecycline: Tigecycline-resistant Enterococcus faecalis in an elderly patient: case report

(Source: Reactions)

[Effects of Jiaweisinisan on gastric mucosal ultrastructure and brain-gut axis in a rat model of chronic psychological stress].

CONCLUSION: JWSNS can obviously ameliorate the pathologies of the gastric mucosa cells, regulate the state of brain-gut axis, and modulate the gastric gastrin receptor and jejunal VIPR2 mRNA expressions in rats with chronic psychological stress. PMID: 23353166 [PubMed - in process] (Source: Journal of Southern Medical University)

A Controlled Trial of Ligation Plus Vasoconstrictor Versus Proton Pump Inhibitor in the Control of Acute Esophageal Variceal Bleeding

ConclusionsAfter successful control of acute variceal bleeding by EVL, adjuvant therapy with PPI infusion was similar to combination with vasoconstrictor infusion in terms of initial hemostasis, very early rebleeding rate, and associated with fewer adverse events. (Source: Journal of Gastroenterology and Hepatology)<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>

Health Canada Warns on Interaction of Prilosec with Methotrexate:...

On October 19th, 2012, Health Canada warned on interaction of PPI drugs (including Prilosec) with methotrexate that may lead to serious side effects. Now, AttorneyOne.com, a recognized authority on...(PRWeb December 26, 2012)Read the full story at http://www.prweb.com/releases/2012/12/prweb10271642.htm (Source: PRWeb: Medical Pharmaceuticals)

Effect of omeprazole on the steady-state pharmacokinetics of voriconazole

Wood N, Tan K, Purkins L, Layton G, Hamlin J, Kleinermans D, Nichols D (Source: The Aspergillus Website - articles)

Esomeprazole/omeprazole: Agranulocytosis: case report

(Source: Reactions)

Lansoprazole/omeprazole/pantoprazole: Prurigo and cross-reactivity: case report

(Source: Reactions)

A unique case of peripheral myoclonus

Introduction Myoclonus is a sudden, brief, involuntary muscle jerk, sufficient to cause movement. Cortical myoclonus is well recognised and characterises many neurological diseases1 Myoclonus can be classified by presumed cause or anatomical origin. Peripherally generated myoclonus is not well characterised, with the exception of hemifacial spasm (HFS). Case report A 71-year-old woman awoke with a twitching of her right hand, which persisted despite distraction, sleep or voluntary use of the hand. The &lsquo;twitch&rsquo; comprised a single complex movement, involving contraction of abductor digiti minimi (ADM) and flexor carpi ulnaris (FCU) muscles. It was rhythmic (approximately 1&nbsp;Hz). There was no antecedent trauma to the hand, and no past medical or family history of neurological ...<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>

European court rules AstraZeneca must pay ?52.5m fine for anticompetitive tactics

Source: BMJ Area: News According to a news report published in the British Medical Journal (BMJ), AstraZeneca will have to pay a fine of ?52.5m (£42.4m) for trying to prevent the marketing of cheaper generic versions of omeprazole, after its appeal against a ruling made by the European Commission was rejected in the European Court of Justice. &#160; The dispute between the company and the commission is longstanding and relates to activities undertaken by AstraZeneca between 1993 and 2000. The Commission launched an investigation in 1999 into two allegations: that AstraZeneca had lied to patent lawyers, patent offices, and courts in several member states over the date at which omeprazole had originally been given marketing authorisation; and that by replacing a capsule formulation of ...

When One Medication May Not Be Enough

You may be taking an antacid or proton pump inhibitor or h2 blocker, and not finding relief. This may be because a combination of those remedies would control GERD symptoms better. Each type of drug works in a different way, and alone may only control some of the symptoms. Remember, your doctor is the best source to decide which medications would work best for you GERD symptoms. What are these types of medications? Antacids Antacids work by neutralizing acid in the stomach. They are usually the first remedy doctors will recommend patients take to relief heartburn symptoms. Antacids include Rolaids, Maalox, Mylanta, Tums, Gaviscon, and Chooz. H2 Blockers H2 blockers, also called H2 receptor agonists, are medicines that reduce the amount of acid the stomach produces. H2 blockers includ...

Esomeprazole/methotrexate/omeprazole interaction: Decreased methotrexate clearance: 2 case reports

(Source: Reactions)

Reflux: Why are doctors giving babies heartburn pills meant for adults?

Five months ago, doctors tried to put Sarah&#8217;s youngest child, Sasha, then seven months, on omeprazole. Sasha suffered from reflux even worse than her brothers. (Source: the Mail online | Health)

AstraZeneca Loses Appeal Over Market Abuse Charges

U.K. pharmaceutical company AstraZeneca lost its appeal of a European court ruling that said it used anticompetitive tactics to prevent less-expensive copies of its popular heartburn pill Losec from entering the market. (Source: WSJ.com: Health)<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>

Judgment in Case C-457/10 P AstraZeneca v Commission

Luxembourg, 6 December 2012--The Court dismisses the appeal of the AstraZeneca group, which abused its dominant position by preventing the marketing of generic products replicating Losec AstraZeneca AB and AstraZeneca plc belong to a pharmaceutical... (Source: Drugs.com - Pharma News)

Spaced administration of PA32540 and clopidogrel results in greater platelet inhibition than synchronous administration of enteric-coated aspirin and enteric-coated omeprazole and clopidogrel

Conclusions: PA32540 and clopidogrel spaced 10 hours apart had greater antiplatelet effects than did synchronously administered EC aspirin (81 mg), clopidogrel (75 mg), and EC omeprazole in healthy volunteers. These finding are directly relevant to the treatment for patients with high gastrointestinal risk who require dual-antiplatelet therapy and gastroprotection. (Source: American Heart Journal)

Can 2-oxoglutarate prevent changes in bone evoked by omeprazole?

Conclusions: Omeprazole treatment exerts its effects mostly on bone mineralization and cancellous bone, adversely affecting bone properties. This adverse effect of omeprazole was not markedly abolished by 2-oxoglutaric acid, which acted as an anti-hypergastrinemic agent. (Source: Nutrition)

Effect of TSHAC on Human Cytochrome P450 Activity, and Transport Mediated by P-Glycoprotein.

Authors: Im Y, Kim YW, Song IS, Joo J, Shin JH, Wu Z, Lee HS, Park KH, Liu KH Abstract TSAHC [4'-(p-toluenesulfonylamido)-4-hydroxychalcone] is a promising antitumorigenic chalcone compound, especially against TM4SF5 (four-transmembrane L6 family member 5)-mediated hepatocarcinoma. We evaluated the potential of TSAHC to inhibit the catalytic activities of nine cytochrome P450 isoforms and of P-glycoprotein (Pgp). The abilities of TSAHC to inhibit phenacetin Odeethylation (CYP1A2), coumarin 6-hydroxylation (CYP2A6), bupropion hydroxylation (CYP2B6), amodiaquine Ndeethylation (CYP2C8), diclofenac 4-hydroxylation (CYP2C9), omeprazole 5-hydroxylation (CYP2C19), dextromethorphan O-demethylation (CYP2D6), chlorzoxazone 6-hydroxylation (CYP2E1), and midazolam 1'-hydroxylation (CYP3A) were...

Omeprazole benefit unclear for GI bleeding in seriously ill children

NEW YORK (Reuters Health) - IV omeprazole eventually increases gastric pH in critically ill children, but whether this reduces GI bleeding or boosts the risk of nosocomial infection is unclear, Spanish researchers say. (Source: Modern Medicine)<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>

Adjuvant probiotics improve the eradication effect of triple therapy for Helicobacter pylori infection.

CONCLUSION: Administration of probiotics before or after standard triple therapy may improve H. pylori eradication rates. PMID: 23180952 [PubMed - in process] (Source: World Journal of Gastroenterology)

Omeprazole for GI Bleeding in Seriously Ill ChildrenOmeprazole for GI Bleeding in Seriously Ill Children

IV omeprazole eventually increases gastric pH in critically ill children, but whether this reduces GI bleeding or boosts the risk of nosocomial infection is unclear, Spanish researchers say. Reuters Health Information (Source: Medscape Pediatrics Headlines)

Abstract 189: Omeprazole Decreases Chronic Antihypertensive Effects of Sodium Nitrite [Poster Sesion I with Reception]

Conclusion Treatment with omeprazole blunts the chronic antihypertensive effects of sodium nitrite in 2K1C rats. However, this effect is probably not associated with significant differences in plasma nitrite concentrations. (Source: Hypertension)

Pozen reports positive Phase 1 PA8140 study results

Pozen has reported positive results from Phase 1 study of PA8140, a combination of aspirin (81mg) and omeprazole (40mg). (Source: Drug Development Technology)

0.5 mg/kg versus 1 mg/kg of Intravenous Omeprazole for the Prophylaxis of Gastrointestinal Bleeding in Critically Ill Children: A Randomized Study

Conclusion: Neither of the 2 omeprazole regimens achieved adequate alkalinization of the gastric pH during the first 24 hours. Between 24 and 48 hours, the 1 mg/kg dose maintained the gastric pH greater than 4 for a greater percentage of the time. (Source: The Journal of Pediatrics)<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>

Development of Bilayer Floating Tablet of Amoxicillin and Aloe vera Gel Powder for Treatment of Gastric Ulcers.

The objective of this project work was defined with a view to retain the drug in stomach for better antiulcer activity and substituting one of the synthetic drugs in this therapy with a herbal alternative. Hence, aim of the present work was to design and develop a bilayer floating tablet of amoxicillin and Aloe vera gel powder for the treatment of peptic ulcer. A. vera gel powder is used for its cytoprotective action. Bilayer floating tablets were prepared by applying direct compression technique. The proportion of sodium bicarbonate and citric acid was adjusted to get the least possible lag time with good matrix integrity and total floating time. Polymer concentration was adjusted to get the maximum release in 8 h. The formulation was developed using hydroxypropyl methyl cellulose (HPMC)...

Antiulcerogenic activity of chlorogenic acid in different models of gastric ulcer

Abstract&nbsp;&nbsp;Chlorogenic acid (CGA) is found in many foods, including coffee, berries, potatoes, carrots, wine, apples, and various herbs, and has anti-inflammatory, antidiabetic, and antitumoral actions. The CGA is well absorbed orally, and its effects on gastric ulcer have not been previously reported. The present manuscript evaluated the effect of oral administration of CGA on ethanol/HCl (Et/HCl) or nonsteroidal anti-inflammatory drug (NSAID)-induced gastric ulcer model in male Swiss mice. Animals were pretreated with 0.2&nbsp;% carboxymethylcellulose (vehicle, p.o.), omeprazole (positive control, 30&nbsp;mg/kg, p.o.), carbenoxolone (antioxidant positive control, 100&nbsp;mg/kg, p.o.), or CGA (5, 25, or 50&nbsp;mg/kg, p.o.). One hour later, the gastric ulcer was induced by ...

Who do you rely on for solutions to your reflux and heartburn?

Larry the Cable Guy is dependable for a good laugh when he appears on TV, but what's the joke when Larry is giving health advice? Larry the Cable Guy is now an official spokesperson for Proctor and Gamble's latest heartburn solution, Prilosec OTC. It's not a laughing... (Source: NaturalNews.com)

[Jejunal intussusceptions as a lead point ectopic pancreatic tissue in a 1-year-old male. Case report].

Conclusions: jejunal intussusceptions in children are extremely rare and occur at any age. Main symptoms are intermittent abdominal pain and vomiting. Ultrasonography is the study of choice. Often a lesion is demonstrable as a lead point for the intussusceptions and therefore requires open or laparoscopic surgery. In this case, it was unusual to have the presence of ectopic pancreatic tissue as a lead point. PMID: 23336150 [PubMed - in process] (Source: Cirugia y Cirujanos)

Evaluation of Helicobacter Pylori eradication in pediatric patients by triple therapy plus lactoferrin and probiotics compared to triple therapy alone

Background: To evaluate whether the addition of a probiotic could improve Helicobacter pylori (H.P.)eradication rates and reduce the side effects of treatment in children. Methods: Between July 2008 and July 2011 all patients with a clinical, laboratory and endoscopicdiagnosis of H.P. positive gastritis referred to our Unit were included in the study. Patientssuffering from allergy to any of drugs used in the study, with previous attempts to eradicateH.P. and those who received antibiotics, PPIs or probiotics within 4 weeks were excludedfrom the present study. Patients were randomized into two therapy regimens (group A andB): both groups received standard triple treatment (omeprazole, amoxicillin andclarithromycin) while only group B patients were also given a probiotic (Probinul -Cadigrou...<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>

Evaluation of Helicobacter Pylori eradication in pediatric patients by triple therapy plus lactoferrin and probiotics compared to triple therapy alone

Background: To evaluate whether the addition of a probiotic could improve Helicobacter pylori (H.P.)eradication rates and reduce the side effects of treatment in children. Methods: Between July 2008 and July 2011 all patients with a clinical, laboratory and endoscopicdiagnosis of H.P. positive gastritis referred to our Unit were included in the study. Patientssuffering from allergy to any of drugs used in the study, with previous attempts to eradicateH.P. and those who received antibiotics, PPIs or probiotics within 4 weeks were excludedfrom the present study. Patients were randomized into two therapy regimens (group A andB): both groups received standard triple treatment (omeprazole, amoxicillin andclarithromycin) while only group B patients were also given a probiotic (Probinul -Cadigrou...

OMEPRAZOLE DELAYED RELEASE (Omeprazole) Tablet, Delayed Release [Weeks Leo Co., Inc.]

Updated Date: Oct 26, 2012 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

How To Treat GERD

Your physician will usually suggest certain lifestyle modifications and dietary changes first. If you continue to have symptoms after these modifications, your physician will discuss with you the use of antacids neutralize stomach acid (which includes Rolaids, Maalox, Mylanta, Tums, and Gaviscon), H2 blockers (which includes Tagamet, Pepcid, Zantac, and Axid), and Proton Pump Inhibitors (PPIs) (which includes Prilosec, Prevacid, Nexium, Aciphex, and Protonix). If your physician and you decide a surgical option is needed, the most common surgical treatment for GERD is the fundoplications surgery. Another procedure sometimes used in the treatment of GERD is the radiofrequency treatment.How To Treat GERD originally appeared on About.com Heartburn / GERD on Tuesday, October 23rd, 2012 at 09:55...

Possible benefit from treatment of Helicobacter pylori in antihistamine‚?źresistant chronic urticaria

Conclusion.‚?? Some patients with resistant CU might benefit from H.¬†pylori eradication. (Source: Clinical And Experimental Dermatology)

Methotrexate/omeprazole interaction: Various toxicities: case report

(Source: Reactions)<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>

Inhibition of gastric perception of mild distention by omeprazole in volunteers.

CONCLUSION: Although the precise mechanisms are undetermined, the present study demonstrated that omeprazole decreases mechanosensitivity to mild gastric distension. PMID: 23112550 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)

Diagnosis of Zollinger-Ellison syndrome: Increasingly difficult.

Authors: Ito T, Cadiot G, Jensen RT Abstract In the present paper the increasing difficulty of diagnosis of Zollinger-Ellison syndrome (ZES) due to issues raised in two recent papers is discussed. These issues involve the difficulty and need to withdraw patients suspected of ZES from treatment with Proton Pump Inhibitors (omeprazole, esomeprazole, lansoprazole, rabeprazole, pantoprazole) and the unreliability of many gastrin radioimmunoassays. The clinical context of each of these important issues is reviewed and the conclusions in these articles commented from the perspective of clinical management. PMID: 23112541 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)

The Clopidogrel-PPI Interaction: An Updated Mini-Review.

Authors: Juel J, Pareek M, Jensen SE Abstract Proton pump inhibitors (PPIs) are recommended in patients with prior upper gastrointestinal bleeding and considered appropriate in patients with multiple other risk factors who require dual antiplatelet treatment (DAPT). During the past few years, however, concerns have been raised about the potential for PPIs, especially omeprazole, to decrease the efficacy of clopidogrel, and both the U.S. Food and Drug Administration (FDA) and European Medicines Agency (EMA) have issued warnings regarding the concomitant use of these medications. A review of the literature revealed that the pharmacodynamic studies support an interaction, whereas the clinical evidence, which is mainly based on non-randomized, observational studies and secondary analys...

Effect of omeprazole on vacuole size in Coxiella burnetii-infected cells

Coxiella burnetii, the etiologic agent of Q fever, is an obligate intracellular bacterium that lives and multiplies in the phagolysosomes of infected cells. Q fever can be acute, with pneumonia and hepatitis being the major clinical manifestations, or chronic, with endocarditis being the most frequent clinical manifestation, followed by vascular infection. (Source: Journal of Infection)

Lansoprazole/omeprazole: Anaphylaxis: 2 case reports

(Source: Reactions)<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>

Omeprazole: Hypomagnesaemia in an elderly patient: case report

(Source: Reactions)

Omeprazole: Anaphylaxis: case report

(Source: Reactions)

Omeprazole: Hypomagnesaemia and hypocalcaemia in an elderly patient: case report

(Source: Reactions)

Carbamazepine/clarithromycin/omeprazole interaction: Ataxia and vertigo: case report

(Source: Reactions)

Interactions of pharmaceuticals and other xenobiotics on key detoxification mechanisms and cytoskeleton in Poeciliopsis lucida hepatocellular carcinoma, PLHC-1 cell line.

This study focuses on effects of chemicals, including nine classes of pharmaceuticals, on key detoxification mechanisms in a fish liver cell-line (PLHC-1). Chemical interactions were investigated on efflux pumps, P-glycoprotein (Pgp) and multidrug resistance associated proteins (MRP1/MRP2), and on biotransformation enzymes, cytochrome P450 (CYP1A/CYP3A). Diclofenac and troleandomycin inhibited efflux activities, whereas ethinylestradiol activated efflux function. Exposure to troleandomycin and ő≤-naphthoflavone induced MRP2 mRNA levels, but no effects were seen on MRP1 or Pgp expressions. Inhibition of CYP1A activities were seen in cells exposed to őĪ-naphthoflavone, ő≤-naphthoflavone, clotrimazole, nocodazole, ketoconazole, omeprazole, ethinylestradiol, lithocholic acid, rifampicin and tr...<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>

A randomized controlled study comparing omeprazole and cimetidine for the prophylaxis of stress-related upper gastrointestinal bleeding in patients with intracerebral hemorrhage.

Conclusions Omeprazole significantly reduced the morbidity of stress-related UGI bleeding in patients with ICH due to its effective prophylactic effect without increasing the risk of nosocomial pneumonia, but it did not reduce the 1-month mortality or ICU stay. Further evaluation of high-dose omeprazole as the drug of choice for patients presenting with UGI bleeding is warranted. Clinical trial registration no.: ChiCTR-TRC-12001871, registered at the Chinese clinical trial registry ( http://www.chictr.org/en/proj/show.aspx?proj=2384 ). PMID: 23061387 [PubMed - as supplied by publisher] (Source: Journal of Neurosurgery)

Cardiovascular outcomes associated with concomitant use of clopidogrel and proton pump inhibitors in patients with acute coronary syndrome in Taiwan

CONCLUSIONS Our study indicated no statistically significant increase in the risk of rehospitalization for ACS due to concurrent use of clopidogrel and PPIs overall. Among individual PPIs, only omeprazole was found to be statistically significantly associated with increased risk of rehospitalization for ACS. (Source: British Journal of Clinical Pharmacology)

Safety profile of enantiomers vs. racemic mixtures: it's the same?

CONCLUSIONS The profile of ADRs could differ for some drugs marketed as racemic and enantiomeric forms. Further studies would be necessary to confirm these data. (Source: British Journal of Clinical Pharmacology)

Association Between Common Heartburn Drugs And Risk Of Pneumonia Questionsed By Study

Previous studies that have associated the use of proton pump inhibitors (PPI) - which include popular anti-heartburn medications like Prilosec and Nexium - with an increased incidence of pneumonia may not have found a true cause-and-effect relationship. A study that has been released online by the Journal of General Internal Medicine outlines a strategy for determining when the results of such observational studies may have been distorted by unmeasured factors and then finds that may be the case with the association between PPIs and pneumonia risk... (Source: Health News from Medical News Today)

PRILOSEC (Omeprazole Magnesium) Capsule, Delayed Release PRILOSEC (Omeprazole Magnesium) Granule, Delayed Release [AstraZeneca LP]

Updated Date: Oct 4, 2012 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>

Association between common heartburn drugs and risk of pneumonia questioned

Previous studies associating the use of proton pump inhibitors (PPI) -- which include popular anti-heartburn medications like Prilosec and Nexium -- with an increased incidence of pneumonia may not have found a true cause-and-effect relationship. A new study outlines a strategy for determining when the results of such observational studies may have been distorted by unmeasured factors and then finds that may be the case with the association between PPIs and pneumonia risk. (Source: ScienceDaily Headlines)

Study questions association between common heartburn drugs and risk of pneumonia

(Massachusetts General Hospital) Previous studies associating the use of proton pump inhibitors (PPI) -- which include popular anti-heartburn medications like Prilosec and Nexium -- with an increased incidence of pneumonia may not have found a true cause-and-effect relationship. A new study outlines a strategy for determining when the results of such observational studies may have been distorted by unmeasured factors and then finds that may be the case with the association between PPIs and pneumonia risk. (Source: EurekAlert! - Medicine and Health)

Effects of statins in an indomethacin-induced gastric injury model in rats.

Conclusions: In patients with gastric discomfort, statins must be used carefully. If statin therapy is needed, we recommend to avoid using atorvastatin and to use the other statins only in the minimum effective dose. PMID: 23161290 [PubMed - in process] (Source: The Turkish Journal of Gastroenterology)

Influence of Helicobacter pylori infection on ghrelin levels in children.

CONCLUSION: H. pylori eradication increases the plasma and tissue ghrelin levels in children with H. pylori-associated functional dyspepsia. PMID: 23049220 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)

Prilosec pills getting berry flavoring

Procter & Gamble adding it to well-known heartburn med even though it's meant to be swallowed (Source: Health News: CBSNews.com)<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>

PRILOSEC OTC (Omeprazole Magnesium) Tablet, Delayed Release [Procter Gamble Manufacturing Company]

Updated Date: Sep 12, 2012 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

Utilization of Omeprazole to Augment Subtherapeutic Voriconazole Concentrations for Treatment of Aspergillus: Case Report and Review of the Literature

Boyd NK, Zoellner CL, Swancutt MA, Bhavan KP (Source: The Aspergillus Website - articles)

Recurrent epigastric pain with obscure GI bleeding; think beyond the bowel?

Clinical presentation A 74-year-old male patient presented with epigastric pain, recurrent melaena and anaemia. His medical history included myocardial infarction, rheumatoid arthritis, diet-controlled type 2 diabetes and recent endovascular infrarenal abdominal aortic aneurysm repair. He was taking aspirin, omeprazole, methotrexate and sulfasalazine. He had stopped smoking for 10&nbsp;years and was a teetotaller. Upper gastrointestinal (GI) endoscopy did not demonstrate any stigmata of recent haemorrhage. No contrast leak was demonstrated on mesenteric arteriography. CT angiography also did not reveal any contrast extravasation or aortoenteric fistulae, although pancreatic tail calcification was noted (figure 1). Serum amylase and lipase were normal. He had recurrent similar presentations...

Impact of dual antiplatelet therapy with proton pump inhibitors on the outcome of patients with acute coronary syndrome undergoing drug-eluting stent implantation.

This study aimed to assess if proton pump inhibitors (PPIs) may reduce the effectiveness of clopidogrel, than H2 antagonist (anti-H2) in order to determine rehospitalization for acute coronary syndrome (re-ACS), target vessel revascularization (TVR) and cardiac death. This case-control study included 176 patients with ACS undergoing angioplasty (PCI) with drug-eluting stent implantation. The population was divided into two groups: PPI group (n = 121) consisting of patients receiving at discharge dual antiplatelet therapy (DAT) plus PPI and anti-H2 group (n = 55), consisting of patients receiving at discharge DAT‚??+‚??H2 receptor antagonist (H2RA). In a followup of 36 months the prevalence of ACS event (P = 0.014), TVR (P = 0.031) was higher in the PPI group than in the anti-H2 group; inst...

Apical acidity decreases inhibitory effect of omeprazole on Mg2+ absorption and claudin-7 and -12 expression in Caco-2 monolayers.

Authors: Thongon N, Krishnamra N Abstract Clinical studies reported hypomagnesaemia in long-term omeprazole usage that was probably due to intestinal Mg2+ wasting. Our previous report demonstrated the inhibitory effect of omeprazole on passive Mg2+ transport across Caco-2 monolayers. The present study aimed to identify the underlying mechanism of omeprazole suppression of passive Mg2+ absorption. By using Caco-2 monolayers, we demonstrated a potent inhibitory effect of omeprazole on passive Mg2+, but not Ca2+, transport across Caco-2 monolayers. Omeprazole shifted the %maximum passive Mg2+ transport - Mg2+ concentration curves to the right, and increased the half maximal effective concentration of those dose - response curves, indicating a lower Mg2+ affinity of the paracellular ch...<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>

Refractory Ulcer of Reconstructed Gastric Tube after Esophagectomy: A Case Report.

We report a case in which rabeprazole cured gastric tube ulcer after esophagectomy for esophageal squamous cell carcinoma (ESCC). A 47-year-old Japanese man was referred to our hospital with refractory ulcer of the reconstructed gastric tube one year after esophagectomy for ESCC. The ulcer proved refractory to healing by the administration of omeprazole or lansoprazole, or eradication of Helicobacter pylori after examinations concerning ischemia, acid over-secretion and H. pylori infection. Finally, metabolizer type was examined for proton pump inhibitors (PPIs), revealing the patient as a hetero-extensive metabolizer for the CYP2C19 genotype. This suggested sensitivity to rabeprazole, but resistance to omeprazole and lansoprazole. The refractory ulcer was subsequently cured after changing...

Antiulcerogenic and antibacterial activities of Apium graveolens essential oil and extract.

This study investigates the antiulcerogenic and antibacterial activities of Apium graveolens extracts. The antiulcerogenic activity was evaluated in rats by the HCl/EtOH method. Inhibition of gastric lesions by A. graveolens extracts was dose-dependent for both aerial part (53-76%) and seeds (51-95%). The methanolic extract as well as the aqueous extracts used at 300‚??mg‚??kg(-1) dose exhibited a highly significant inhibition of gastric lesions (91% and 95%, respectively) which was similar to that induced by omeprazole (94%). Essential oil and aqueous extract prepared from the aerial parts of A. graveolens were tested to determine their antibacterial activity using the paper disc-diffusion method, the minimal inhibitory concentration and the minimal bactericidal concentration. Essential o...

Molecular Pharmacological Approaches to Effects of Capsaicinoids and of Classical Antisecretory Drugs on Gastric Basal Acid Secretion and on Indomethacin-Induced Gastric Mucosal Damage in Human Healthy Subjects.

Conclusions: Comparison classical antisecretory drugs acting on different pathways but in much more higher molar concentrations. The atropine and capsaicinoids act in about the same molar concentration which suggests a significant physiological role for capsaicin sensitive afferent nerves in the regulation of gastric basal acid secretion and in the prevention of chemically-induced gastric mucosal protection in human healthy subjects, suggesting a novel physiological pathway in regulation. These results clearly indicate the molecular pharmacological backgrounds of actions of classical antisecretory drugs and physiological role of capsaicin-sensitive afferent nerves in human healty subjects on the gastric basal secretion and on the prevention of drug-induced gastric mucosal damage. PMID:...

Gastroprotective effects of extracts and guttiferone A isolated from Garcinia achachairu Rusby (Clusiaceae) against experimentally induced gastric lesions in mice

This study was undertaken to evaluate the gastroprotective properties of seed, leaf, and branch methanolic extracts and guttiferone A obtained from Garcinia achachairu (Clusiaceae). Mice were used in all the models, and treatments were administered orally only in pylorus-ligated model of the extracts, and drugs were administered intraduodenally. Treatment with different extracts (500&nbsp;mg/kg) significantly reduced the ulcerative lesions in the ethanol/HCl-induced model; however, the seed extract was most active. When tested in different doses (50, 250, or 500&nbsp;mg/kg), the seed extract of G. achaicharu showed a dose-dependent effect with a percentage of inhibition of gastric lesions of 41, 49, and 85&nbsp;%, respectively. The seed extract also significantly reduced the ulcerativ...

Case Report: fatal GI bleed 6 days after one dose of dabigatran (Pradaxa)

3 out of 5 stars Fatal gastrointestinal hemorrhage after a single dose of dabigatran. Kernan L et al. Clin Toxicol 2012;50:571-573. Abstract The RE-LY trial, the major study evaluating use of dabigatran etexilate (Pradaxa) as an anticoagulant to prevent stroke in patients with atrial fibrillation, excluded subjects with creatinine clearance less than 30 ml per minute. Since elderly patients frequently have undetected renal insufficiency, sometimes with normal creatinine levels, this population is at increased risk for major bleeding when taking this drug. In fact, in the European Union, the manufacturer recommends that patients older than 75 years of age have renal function tested before being put on dabigatran and regularly thereafter. This somewhat puzzling case report reinforces this ...<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>

Diagnosis and Management of Laryngo-Pharyngeal Reflux

Abstract&nbsp;&nbsp;The aim of the present paper was to analyze laryngo-pharyngeal reflux (LPR) manifestations in ENT patients, and present a diagnostic and treatment algorithm for appropriate management. Retrospective chart review of 150 patients, who had initially presented with symptoms suggestive of LPR. Treatment included the administration of omeprazole 20&nbsp;mg twice daily for at least 4&nbsp;weeks. Unresponsive patients were also given metoclopramide 10&nbsp;mg twice daily for four additional weeks, and the dose of omeprazole was increased to 40&nbsp;mg twice daily, if they did not achieve complete symptom resolution. Only patients who became completely asymptomatic after LPR treatment were included in the study. As many as 18&nbsp;% of patients attending an ENT outpatient ...

PRILOSEC OTC (Omeprazole Magnesium) Tablet, Delayed Release [Procter Gamble Manufacturing Company]

Updated Date: Aug 21, 2012 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

Suspected Methotrexate Toxicity From Omeprazole: A Case Review of Carboxypeptidase G2 Use in a Methotrexate-Experienced Patient With Methotrexate Toxicity and a Review of the Literature

We report a case of methotrexate toxicity potentially induced by a drug interaction between methotrexate and omeprazole in a 25-year-old man with osteosarcoma. The patient was placed on omeprazole after his first cycle of high-dose methotrexate for stress ulcer prophylaxis, and it was discontinued before the start of the first day of the patient&rsquo;s second round of high-dose methotrexate. The 24-hour methotrexate level was elevated and he continued to have sustained levels for 18 days. Side effects due to elevated serum methotrexate included seizures, mucositis, acute renal failure, and thrombocytopenia. Aggressive hydration, urinary alkalinization, and leucovorin were continued during the period of elevated methotrexate levels, with the patient receiving a course of hemodialysis and a...

Pharmacokinetic Interaction between Prasugrel and Ritonavir in Healthy Volunteers

Abstract The new anti‚?źaggregating agent prasugrel is bioactivated by cytochromes P450 (CYP) 3A and 2B6. Ritonavir is a potent CYP3A inhibitor and was shown in vitro as a CYP2B6 inhibitor. The aim of this open‚?źlabel cross‚?źover study was to assess the effect of ritonavir on prasugrel active metabolite (prasugrel‚?źAM) pharmacokinetics in healthy volunteers. Ten healthy male volunteers received 10 mg prasugrel. After at least a week washout, they received 100 mg ritonavir, followed by 10 mg prasugrel 2 hr later. We used dried blood spot sampling method to monitor prasugrel‚?źAM pharmocokinetics (Cmax, t1/2, tmax, AUC0‚?ź6h) at 0, 0.25, 0.5, 1, 1.5, 2, 4 and 6 hr after prasugrel administration. A ‚??cocktail‚?Ě approach was used to measure CYP2B6, 2C9, 2C19 and 3A activities. In the pres...

Omeprazole: Subacute cutaneous lupus erythematosus in an elderly patient: case report

(Source: Reactions)<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>

Santarus files patent infringement lawsuit against Dr Reddy‚??s

US-based drugmaker Santarus has filed a lawsuit against Indian pharmaceutical company Dr Reddy‚??s Laboratories over the alleged patent infringement of heartburn medication Zegerid. (Source: Pharmaceutical Technology)

Santarus sues Dr Reddy's over heartburn drug

(Reuters) - U.S. drugmaker Santarus Inc said it filed a lawsuit against Dr. Reddy's Laboratories, accusing the Indian drugmaker of infringing its patents on heartburn drug Zegerid. (Source: Reuters: Health)

Levofloxacin versus clarithromycin in a 10 day triple therapy regimen for first-line Helicobacter pylori eradication: a single-blind randomized clinical trial

Conclusions Levofloxacin-based treatment for H. pylori infection did not improve upon the eradication rate of the standard clarithromycin-based triple therapy in this study. This may reflect the progressive increase in in vitro resistance rates to levofloxacin observed in our region. (Source: Journal of Antimicrobial Chemotherapy)

Utilization of Omeprazole to Augment Subtherapeutic Voriconazole Concentrations for Treatment of Aspergillus: Case Report and Review of the Literature.

We report a voriconazole 'boosting' effect of omeprazole to achieve target concentrations for treatment of Aspergillus in a patient who was persistently subtherapeutic. PMID: 22890768 [PubMed - as supplied by publisher] (Source: Antimicrobial Agents and Chemotherapy)

Monitoring the On-line Titration of Enantiomeric Omeprazole Employing Continuous-flow Capillary Microcoil (1) H NMR Spectroscopy.

Authors: Hentschel P, Holtin K, Steinhauser L, Albert K Abstract The titration of the (S)-enantiomer of omeprazole with the (R)-enantiomer in chloroform-d(1) is monitored by continuous-flow capillary microcoil (1) H NMR spectroscopy employing a microcoil with a detection volume of 1.5‚??¬Ķl. The observed changes of the (1) H NMR chemical shifts indicate the formation of a heterochiral (R,S) dimer of omeprazole via its sulfinyl group and the NH group of the benzimidazole ring. Chirality 00:000-000, 2012. ¬© 2012 Wiley Periodicals, Inc. PMID: 22887745 [PubMed - as supplied by publisher] (Source: Chirality)<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>

Correction

Frelinger III AL, Lee RD, Mulford DJ, Wu J, Nudurupati S, Nigam A, Brooks JK, Bhatt DL, Michelson AD. A Randomized, 2-Period, Crossover Design Study to Assess the Effects of Dexlansoprazole, Lansoprazole, Esomeprazole, and Omeprazole on the Steady-State Pharmacokinetics and Pharmacodynamics of Clopidogrel in Healthy Volunteers. J Am Coll Cardiol 2012;59:1304‚??11. (Source: Journal of the American College of Cardiology)

Partial symptom‚?źresponse to proton pump inhibitors in patients with non‚?źerosive reflux disease or reflux oesophagitis ‚?? a post hoc analysis of 5796 patients

ConclusionUsing our conservative definition, partial heartburn response to PPI therapy occurred in 14‚??20% of GERD patients, more commonly in non‚?źerosive reflux disease than in reflux oesophagitis. (Source: Alimentary Pharmacology and Therapeutics)

Correction

Frelinger III AL, Lee RD, Mulford DJ, Wu J, Nudurupati S, Nigam A, Brooks JK, Bhatt DL, Michelson AD. A Randomized, 2-Period, Crossover Design Study to Assess the Effects of Dexlansoprazole, Lansoprazole, Esomeprazole, and Omeprazole on the Steady-State Pharmacokinetics and Pharmacodynamics of Clopidogrel in Healthy Volunteers. J Am Coll Cardiol 2012;59:1304‚??11. (Source: Journal of the American College of Cardiology: Cardiovascular Imaging)

How To Treat GERD

Your physician will usually suggest certain lifestyle modifications and dietary changes first. If you continue to have symptoms after these modifications, your physician will discuss with you the use of antacids neutralize stomach acid (which includes Rolaids, Maalox, Mylanta, Tums, and Gaviscon), H2 blockers (which includes Tagamet, Pepcid, Zantac, and Axid), and Proton Pump Inhibitors (PPIs) (which includes Prilosec, Prevacid, Nexium, Aciphex, and Protonix). If your physician and you decide a surgical option is needed, the most common surgical treatment for GERD is the fundoplications surgery. Another procedure sometimes used in the treatment of GERD is the radiofrequency treatment.How To Treat GERD originally appeared on About.com Heartburn / GERD on Sunday, July 29th, 2012 at 15:55:50....

Helicobacter heilmannii gastritis in a young patient with a pet

A 17-year-old man with familial adenomatous polyposis was evaluated for heartburn. On EGD, mildly erythematous and micronodular mucosa was seen in the gastric corpus and antrum (). Biopsy specimens revealed chronic inactive gastritis () with focally prominent intraepithelial lymphocytes resembling so-called lymphoepithelial lesions (; arrowheads). A Giemsa stain revealed relatively long (5-10 őľm), tightly coiled organisms on the gastric surface and within crypts (). The organisms reacted in a routine immunohistochemical stain for Helicobacter pylori (; inset); however, electron microscopy () highlighted ultrastructural features of the microbes (3-8 coils, about 1 őľm helical pitch) leading to the diagnosis of Helicobacter heilmannii gastritis. A species-specific polymerase chain reaction ...<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>

Evaluation of seven drug metabolisms and clearances by cryopreserved human primary hepatocytes cultivated in microfluidic biochips.

We present characterization of the metabolic performance of human cryopreserved hepatocytes cultivated in a platform of parallelized microfluidic biochips. The RTqPCR analysis revealed that the mRNA levels of the cytochromes P450 (CYP 1A2, 2B6, 2C8, 2C9, 2C19, 2D6, 2E1, 3A4) were reduced after the adhesion period (when compared to the post-thawing step). The microfluidic perfusion played a part in stabilizing and partially recovering the levels of the HNF4őĪ, PXR, OAPT2, CYP 1A2, 2B6, 2C19 and 3A4 mRNA on contrary to non-perfused cultures. Fluorescein diacetate staining and P-gp mRNA level illustrated the hepatocytes' polarity in the biochips. Drug metabolism was assessed using midazolam, tolbutamide, caffeine, omeprazole, dextromethorphan, acetaminophen and repaglinide as probes. Metaboli...

Effects of omeprazole and pantoprazole on immunoglobulin G absorption in the newborn calves

In conclusion, the results of this study showed that increasing pH of the abomasum with proton pump inhibition drugs such as omeprazole and pantoprazole did not markedly influence the efficiency of IgG absorption in newborn calves. Content Type Journal ArticleCategory Original ArticlePages 1-5DOI 10.1007/s00580-012-1565-8Authors Mohammad Reza Shirazi, Department of Clinical Sciences, Faculty of Veterinary Medicine, Shahid Chamran University of Ahvaz, Ahvaz, IranMohammad Nouri, Department of Clinical Sciences, Faculty of Veterinary Medicine, Shahid Chamran University of Ahvaz, Ahvaz, IranMasoud Ghorbanpour Najaf Abadi, Department of Pathobiology, Faculty of Veterinary Medicine, Shahid Chamran University of Ahvaz, Ahvaz, IranPeter D. Constable, Department of Veterinary Clinical Scien...

[Hemodynamic effects of intravenous omeprazole in critically ill children.]

CONCLUSIONS: Intravenous omeprazole administration of 0.5mg/kg and 1mg/kg is a hemodynamically safe drug in critically ill children. PMID: 22818224 [PubMed - as supplied by publisher] (Source: Anales de Pediatria)

Tetany, Hypomagnesemia, and Proton-pump Inhibitors

A 58-year-old woman on omeprazole for more than 1 year (40 mg daily) had relapsing carpopedal spasms. She did not complain of diarrhea or vomiting or any other symptoms and also was taking furosemide and bisoprolol for hypertension. (Source: The American Journal of Medicine)

Risk factors associated with a decrease ‚?•2¬†g/dL in haemoglobin and/or ‚?•10% haematocrit in osteoarthritis patients taking celecoxib or a nonselective NSAID plus a PPI in a large randomised controlled trial (CONDOR)

ConclusionsMonitoring for decreases in haemoglobin should be considered for all OA patients and especially those with an increased age, BMI, history of gastritis and GI intolerance, CRP levels &gt;1 mg/dL and/or positive H. pylori status, as this may affect their clinical management. (Source: Alimentary Pharmacology and Therapeutics)<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>

Respiratory response to proton pump inhibitor treatment in children with obstructive sleep apnea syndrome and gastroesophageal reflux disease

Abstract: Objective: Evaluation of the respiratory response to proton pump inhibitors (PPI) in children with obstructive sleep apnea syndrome (OSAS) and gastroesophageal reflux disease (GERD).Methods: Of 131 children diagnosed with OSAS (Apnea Hypopnea Index, AHI >1/h), 37 children (6.9years; 28.24%) with GERD symptoms (>3times/week) were included. Overnight polysomnography with 24h pH-metry was performed before and after 4‚??8weeks of PPI treatment (omeprazole once a day, 1mg/kg).Results: Of 37 children, 21 were diagnosed with acid GERD where pre- and post-treatment reflux indexes were 14.09¬Ī1.47 vs. 7.73¬Ī1.36; (p (Source: Sleep Medicine)

Effect of Helicobacter pylori on marginal ulcer and stomal stenosis after Roux-en-Y gastric bypass

Conclusion: HP status, whether positive preoperatively or persistently positive after treatment, had no effect on the marginal ulcer or stomal stenosis rates in patients undergoing RYGB in the present study. (Source: Surgery for Obesity and Related Diseases)

Biological efficacy of a 600 mg loading dose of clopidogrel in ST-elevation myocardial infarction.

In conclusion, STEMI is associated with high on-treatment platelet reactivity following 600 mg of clopidogrel. The present results suggest that 600 mg of clopidogrel may not be able to achieve an optimal PR inhibition in STEMI patients undergoing PCI and more potent drugs may be preferred. PMID: 22535315 [PubMed - in process] (Source: Thrombosis and Haemostasis)

Lycopene an Adjunctive Therapy for Helicobacter Pylori Eradication: a Quasi-Control Trial

Although some herbal remedies in association with vitamin therapy have been investigated in eradicating HP, no research has been done to investigate the effects of lycopene it. Our aim was to understand if lycopene could be effective in eradication of HP. In this parallel group quasi-control trial, a total of 54 patients whose diagnosis of HP had been confirmed by rapid urease test (RUT) were enrolled. Group 1 received the standard 4-drug therapy to eradicate HP (Metronidazole 500 mg/BD, Amoxicillin 1g/BD, Omeprazole 20mg/BD, and Bismuth 240 mg/BD) and group 2 received the same regimen in association with Lycopene (30 mg/daily). One month after the initiation of the treatment, the patients were evaluated for HP eradication by RUT. Although eradication rate was higher in the second group, b...

Helicobacter pylori Eradication with Ecabet Sodium, Omeprazole, Amoxicillin, and Clarithromycin Versus Bismuth, Omeprazole, Amoxicillin, and Clarithromycin Quadruple Therapy: A Randomized, Open‚?źLabel, Phase IV Trial

ConclusionsNeither 10‚?źday Ecabet sodium‚??containing quadruple therapy or 10‚?źday bismuth‚?źcontaining quadruple therapy can be recommended as empiric therapy in cities with high antibiotic resistance rate of China. (Source: Helicobacter)<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>

Different effects of proton pump inhibitors and famotidine on the clopidogrel metabolic activation by recombinant CYP2B6, CYP2C19 and CYP3A4.

Authors: Ohbuchi M, Noguchi K, Kawamura A, Usui T Abstract Inhibitory potential of proton pump inhibitors (PPIs) and famotidine, an H(2) receptor antagonist, on the metabolic activation of clopidogrel was evaluated using recombinant CYP2B6, CYP2C19 and CYP3A4. Formation of the active metabolite from an intermediate metabolite, 2-oxo-clopidogrel, was investigated by liquid chromatography-tandem mass spectrometry and three peaks corresponding to the pharmacologically active metabolite and its stereoisomers were detected. Omeprazole potently inhibited clopidogrel activation by CYP2C19 with an IC(50) of 12.8 őľmol/L and more weakly inhibited that by CYP2B6 and CYP3A4. IC(50) of omeprazole for CYP2C19 and CYP3A4 was decreased about two- and three-fold, respectively, by 30-min preincubat...

Abstracts.

Conclusion Patients who had risk factors identified by staff as being of most importance were no more likely to receive prophylactic treatment than patients with other risk factors. References 1. Report of the independent expert working group on the prevention of venous thromboembolism in hospitalised patients. Department of Health; 2007. 2. The prevention of Venous Thromboembolism in Hospitalised Patients Second Report of Session 2004-2005. House of Commons Health Committee; 2005. 3. Rashid ST, Thursz MR, Razvi NA, Voller R, Orchard T, Shlebak AA. Venous thromboprophylaxis in UK medical inpatients. Journal of the Royal Society of Medicine. 2005;98:507-12. 4. Samama MM, Cohen AT, Darmon JY, Desjardins L, Eldor A, Janbon C, et al. A comparison of enoxaparin with placebo for the prevention o...

Variation in omeprazole pharmacokinetics in a random Iranian population: a pilot study

ABSTRACT Omeprazole is metabolized in the liver mainly by the polymorphic CYP2C19 enzyme. Considerable ethnic differences have been reported in pharmacokinetics of omeprazole. The present study was conducted to evaluate pharmacokinetic parameters of omeprazole after single oral administration to a random Iranian population. 30 healthy male subjects, aged 24‚??31‚??years, weighing 60‚??98‚??kg completed the study. Plasma concentrations of omeprazole were measured over a 12‚??h period after administration of a single oral dose of 20‚??mg omeprazole. The pharmacokinetic parameters were calculated from the plasma concentration‚?źtime profiles. Liquid chromatography coupled to tandem mass spectrometry (LC‚?źMS/MS) was used to quantify 5‚?źHydroxyomeprazole. The mean area under the concentration...

Merck, Astra keep drug alliance for two more years

(Reuters) - Merck & Co will keep booking sales and profits for two more years tied to AstraZeneca Plc's widely used acid reflux medicines Nexium and Prilosec under an amended agreement between the two large drugmakers. (Source: Reuters: Health)

Merck to keep recording income from Astra drugs

(Reuters) - Merck & Co will keep recording sales and profits for two more years tied to AstraZeneca PLC's widely used acid reflux drugs Nexium and Prilosec under an amended agreement between the two large drugmakers. (Source: Reuters: Health)<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>

Hypersensitivity to proton pump inhibitors: Diagnostic accuracy of skin tests compared to oral provocation test

Proton pump inhibitors (PPIs) are widely used for the treatment of acid-related gastrointestinal diseases because they reduce the gastric acid secretion by blocking the H+/K+-ATPase. PPIs include omeprazole, lansoprazole, rabeprazole, pantoprazole, and esomeprazole. PPIs are generally well tolerated, and side effects occur in about 1% of the patients. Hypersensitvity reactions are also rare, but several reports have described anaphylaxis, urticaria, or asthma. The diagnosis of hypersensitivity to PPIs is difficult since PPIs are often used in combination with other drugs. The oral provocation test (OPT) remains a reasonable approach to confirm hypersensitivity, but it is time-consuming and not devoid of risks. Thus, a reliable in vivo test to replace OPT would be desirable. Skin tests for...

Ultrastructure of ECL cells in Mastomys after long-term treatment with H2 receptor antagonist loxtidine

Abstract&nbsp;&nbsp;Gastric ECL-cell hyperplasia and carcinoids (ECLoma) develop after 1 year in rats treated with omeprazole or 2 months in Mastomys treated with loxtidine. The aim of this study was to examine the ultrastructure of ECL cells in Mastomys after loxtidine treatment with an attempt to evaluate whether an impairment of autophagy was involved in the tumorigenesis. Mastomys were given loxtidine for 8 or 27 weeks. Morphological analysis of ECL cells showed that (1) cell size was not increased after 8 or 27 weeks; (2) secretory vesicles, a hallmark feature of welldifferentiated ECL cells, were unchanged after 8 weeks but reduced after 27 weeks; (3) granules were reduced after 8 or 27 weeks; (4) microvesicles were unchanged after the treatment; and (5) vacuoles and lipofuscin b...

CORRECTION: FDA says investigational aspirin-omeprazole combo may need more data

(Source: Modern Medicine)

The cholecystokinin CCK2 receptor antagonist, JNJ‚?ź26070109, inhibits gastric acid secretion and prevents omeprazole‚?źinduced acid rebound in the rat

CONCLUSIONS AND IMPLICATIONSChronic administration of JNJ‚?ź26070109 effectively inhibited gastric acid secretion and suppressed proton pump inhibitor (PPI)‚?źinduced acid rebound in the rat. This work advances the field by demonstrating that modest doses of a competitive CCK2 receptor antagonist have significant and functionally important anti‚?źtrophic actions in the gastric mucosa. These properties make JNJ‚?ź26070109 a suitable candidate for clinical investigation for the treatment of GORD. (Source: British Journal of Pharmacology)

Nine cases of allergy to omeprazole.

Authors: Abdul Razzak E, Tom√?¬?√?¬°s M, Tornero P, Herrero T PMID: 22697020 [PubMed - in process] (Source: Journal of Investigational Allergology and Clinical Immunology)<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>

Increase in gastric pH reduces hypotensive effect of oral sodium nitrite in rats.

In this study, we tested the hypothesis that increases in gastric pH caused by omeprazole could decrease the hypotensive effect of oral sodium nitrite. We assessed the effects of omeprazole treatment on the acute hypotensive effects produced by sodium nitrite in normotensive and L-NAME-hypertensive free-moving rats. In addition, we assessed the changes in gastric pH and plasma levels of nitrite, NO(x) (nitrate+nitrite), and S-nitrosothiols caused by treatments. We found that the increases in gastric pH induced by omeprazole significantly reduced the hypotensive effects of sodium nitrite in both normotensive and L-NAME-hypertensive rats. This effect of omeprazole was associated with no significant differences in plasma nitrite, NO(x), or S-nitrosothiol levels. Our results suggest that part ...

Influence of Helicobacter pylori Infection on Gastric Acid Secretion in Pre‚?źSchool Bangladeshi Children

ConclusionThe results suggest that the gastric barrier is compromised in children with H.¬†pylori infection in Bangladesh. Improvement of GAO following anti‚?ź H.¬†pylori therapy suggests a causal link between H.¬†pylori infection and depressed GAO in this population. (Source: Helicobacter)

Tigecycline-resistant Enterococcus faecalis associated with omeprazole use in a surgical patient

(Source: Journal of Antimicrobial Chemotherapy)

Greater Than 95% Success with 14‚?źday Bismuth Quadruple Anti‚?ź Helicobacter pylori Therapy: A Pilot Study in US Hispanics

ConclusionsThis pilot study supports the concept that 14‚?źday OBMT therapy is likely to be more efficacious for H.¬†pylori eradication (Grade A, PP basis) than a 10‚?źday course where metronidazole resistance is suspected. If confirmed, 14¬†days should be recommended in populations where metronidazole resistance is common. (Source: Helicobacter)

Greater Than 95% Success with 14‚?źday Bismuth Quadruple Anti‚?źHelicobacter pylori Therapy: A Pilot Study in US Hispanics

ConclusionsThis pilot study supports the concept that 14‚?źday OBMT therapy is likely to be more efficacious for H.¬†pylori eradication (Grade A, PP basis) than a 10‚?źday course where metronidazole resistance is suspected. If confirmed, 14¬†days should be recommended in populations where metronidazole resistance is common. (Source: Helicobacter)<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>

Influence of Helicobacter pylori Infection on Gastric Acid Secretion in Pre‚?źSchool Bangladeshi Children

ConclusionThe results suggest that the gastric barrier is compromised in children with H.¬†pylori infection in Bangladesh. Improvement of GAO following anti‚?źH.¬†pylori therapy suggests a causal link between H.¬†pylori infection and depressed GAO in this population. (Source: Helicobacter)

Omeprazole improves the antiobesity and antidiabetic activity of Exendin‚?ź4 in db/db mice

Conclusions:‚?? These results demonstrate that the combination of omeprazole with exendin‚?ź4 leads to reduced food intake and body weight gain, most likely through the changes in plasma ghrelin and leptin and also improves pancreatic insulin and glucagon content by improvement in glucokinase activity.The significant findings of the study:‚?? Omeprazole reinstates the altered gastrin levels and improves the glucoregulatory action of exendin‚?ź4. The addition of omeprazole to exendin‚?ź4 improves the pancreatic insulin and reduces glucagon, and renders long term beneficial effect for the treatment of type 2 diabetes as demonstrated by %HbA1c reduction in db/db mice.This study adds:‚?? A novel combination approach for GLP‚?ź1 based therapies. The study demonstrates that omeprazole addition c...

Effect of a traditional Chinese medicine Liu Wei Di Huang Wan on the activities of CYP2C19, CYP2D6 and CYP3A4 in healthy volunteers.

This study was designed to investigate the potential herb-drug interactions of LDW in healthy volunteers and attempted to ascertain whether the interaction might be affected by genotypes. We assessed the effect of LDW on the activities of CYP2C19, CYP2D6 and CYP3A4 in 12 Chinese healthy subjects in a single-center, controlled, non-blinded, two-way crossover clinical trial. The subject pool consisted of six extensive metabolizers with CYP2C19*1/*1 and six poor metabolizers with CYP2C19*2/*2. Placebo or 4.8‚??g LDW (12 pills, 0.2‚??g/pill, twice daily) was given to each participant for 14 continuous days with a wash-out period of 2 weeks after an oral administration of 30‚??mg omeprazole, 30‚??mg dextromethorphan hydrobromide and 7.5‚??mg midazolam. The activities of CYP2C19, CYP2D6 and C...

Randomised clinical trial: simvastatin as adjuvant therapy improves significantly the Helicobacter pylori eradication rate ‚?ź a placebo‚?źcontrolled study

ConclusionIn this randomised clinical trial simvastatin as adjuvant to standard therapy improves significantly the H. pylori eradication rate. (Source: Alimentary Pharmacology and Therapeutics)

OMECLAMOX-PAK (Omeprazole, Clarithromycin, Amoxicillin) Kit [Pernix Therapeutics, LLC]

Updated Date: May 30, 2012 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>

Lessons from two cases of anaphylaxis to proton pump inhibitors

Conclusion:‚?? Physicians need to be more aware of the possibility of hypersensitivity to PPIs. (Source: Journal of Clinical Pharmacy and Therapeutics)

Comparison of chemical-induced changes in proliferation and apoptosis in human and mouse neuroprogenitor cells.

Authors: Culbreth ME, Harrill JA, Freudenrich TM, Mundy WR, Shafer TJ Abstract There is a need to develop rapid and efficient models to screen chemicals for their potential to cause developmental neurotoxicity. Use of in vitro neuronal models, including human cells, is one approach that allows for timely, cost-effective toxicity screening. The present study compares the sensitivity of human (ReN CX) and mouse (mCNS) neuroprogenitor cell lines to chemicals using a multiplex assay for proliferation and apoptosis, endpoints that are critical for neural development. Cells were exposed to 0.001-100√?¬?√?¬ľM concentrations of 11 chemicals (cadmium, chlorpyrifos oxon, dexamethasone, dieldrin, ketamine, lead, maneb, methylmercury, nicotine, trans-retinoic acid, and trimethyltin) reported i...

The inhibition of major human hepatic cytochrome P450 enzymes by 18 pesticides: Comparison of the N-in-one and single substrate approaches.

Authors: Abass K, Pelkonen O Abstract In the present study on human hepatic microsomes, the N-in-one assay with ten probe substrates for nine cytochrome-P450 enzymes (CYPs) was compared with the single substrate assays to investigate pesticides-CYP interactions. CYP inhibition was measured by liquid chromatography-tandem mass spectrometry (LC/MS-MS). As illustrated by the initial screening at 100őľM concentration of 18 pesticides, CYPs are more sensitive to organophosphates (OPs) than to other pesticide groups. Chlorpyrifos and fenitrothion were most effective in inhibiting CYP1A1/2, and CYP2B6. Profenofos was also inhibitory towards multiple CYPs. Pyrethroids, e.g. deltamethrin, fenvalerate and lambda-cyhalothrin, potently inhibited CYP2D6. CYP3A4 activity was moderately inhibited...

PA32540 Cuts Gastric Acid Faster Than Enteric-Coated Aspirin

SAN DIEGO - The investigational compound PA32540 provides faster gastric protection than enteric-coated omeprazole 40 mg, researchers announced at Digestive Disease Week 2012. PA32540 is an investigational coordinated-delivery tablet of immediate-release (IR) omeprazole (40 mg), a proton pump inhibitor (PPI), layered around enteric-coated aspirin (325 mg). The product was developed to provide the cardiovascular benefits of aspirin in patients at risk for aspirin-associated ulcers... (Source: Health News from Medical News Today)

OMEPRAZOLE AND SODIUM BICARBONATEcapsule [Par Pharmaceutical Inc.]

Updated Date: May 18, 2012 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>

Efficacy of a &#8220;Rescue&#8221; Ciprofloxacin-Based Regimen for Eradication of Helicobacter pylori Infection after Treatment Failures

Conclusions. The effectiveness of ciprofloxacin-based therapy was greatly reduced despite the high prevalence of ciprofloxacin sensitive H. pylori strains. Bismuth based quadruple therapy still remain the best choice as a &#x201c;rescue&#x201d; regimen in our region. (Source: Experimental Diabetes Research)

OMEPRAZOLE/SODIUM BICARBONATE (Omeprazole, Sodium Bicarbonate) Powder, For Suspension OMEPRAZOLE/SODIUM BICARBONATE (Omeprazole, Sodium Bicarbonate) Capsule [Prasco, Laboratories]

Updated Date: May 14, 2012 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

Clopidogrel and proton pump inhibitors - where do we stand in 2012?

Authors: Drepper MD, Spahr L, Frossard JL Abstract Clopidogrel in association with aspirine is considered state of the art of medical treatment for acute coronary syndrome by reducing the risk of new ischemic events. Concomitant treatment with proton pump inhibitors in order to prevent gastrointestinal side effects is recommended by clinical guidelines. Clopidogrel needs metabolic activation predominantly by the hepatic cytochrome P450 isoenzyme Cytochrome 2C19 (CYP2C19) and proton pump inhibitors (PPIs) are extensively metabolized by the CYP2C19 isoenzyme as well. Several pharmacodynamic studies investigating a potential clopidogrel-PPI interaction found a significant decrease of the clopidogrel platelet antiaggregation effect for omeprazole, but not for pantoprazole. Initial clin...

Protective effect of D-002, a mixture of beeswax alcohols, against indomethacin-induced gastric ulcers and mechanism of action

Abstract&nbsp;&nbsp;D-002, a mixture of higher aliphatic beeswax alcohols, produces gastroprotective and antioxidant effects. To investigate the gastroprotective effect of D-002 against indomethacin-induced ulcers, oxidative variables and myeloperoxidase (MPO) activity in the rat gastric mucosa were examined. Rats were randomized into six groups: a negative vehicle control and five indomethacin (50&nbsp;mg/kg) treated groups, comprising a positive control, three groups treated orally with D-002 (5, 25 and 100&nbsp;mg/kg) and one group with omeprazole 20&nbsp;mg/kg intraperitoneally (ip). The contents of malondialdehyde (MDA), protein carbonyl groups (PCG), hydroxyl radical generation and catalase (CAT), glutathione peroxidase (GSH-PX), superoxide dismutase (SOD) and MPO enzyme activi...

ZEGERID (Omeprazole, Sodium Bicarbonate) Capsule [Physicians Total Care, Inc.]

Updated Date: May 8, 2012 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>

Inhibitors of acid secretion can benefit gastric wound repair independent of luminal pH effects on the site of damage

Conclusions Epithelial repair in vivo is affected by luminal pH variation, but the beneficial effects of acutely blocking acid secretion extend beyond simply raising luminal and/or surface pH. (Source: Gut)

Flucloxacillin/omeprazole/pantoprazole: Tubulointerstitial nephritis in elderly patients: 3 case reports

(Source: Reactions)

OMEPRAZOLE (Omeprazole) Capsule, Delayed Release [AvPAK]

Updated Date: May 1, 2012 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

Efficacy of omeprazole, famotidine, mosapride and teprenone in patients with upper gastrointestinal symptoms: an omeprazole-controlled randomized study (J-FOCUS)

Conclusions: The favorable efficacy and safety profiles of omeprazole in relieving uninvestigated uppergastrointestinal symptoms support its use as first-line treatment in this patient group in Japan.Patients who show no improvement in symptoms despite PPI use, and those with alarmsymptoms (such as vomiting, GI bleeding or acute weight loss) should receive furtherinvestigation, including prompt referral for endoscopy.Trial registrationUMIN000005399 (Source: BMC Gastroenterology)

Relative bioavailability and pharmacokinetic comparison of two different enteric formulations of omeprazole.

In this study, the test formulation of OPZ in fasting healthy Chinese male volunteers met the Chinese bioequivalance standard to the reference formulation based on AUC, C(max), and T(peak). PMID: 22556172 [PubMed - in process] (Source: J Zhejiang Univ Sci ...)<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>

Differential inhibitory effects of proton pump inhibitors on the metabolism and antiplatelet activities of clopidogrel and prasugrel

ABSTRACTThe interaction between proton pump inhibitors (PPIs) and clopidogrel/prasugrel were investigated. The IC50 values of omeprazole, esomeprazole, lansoprazole, pantoprazole, and rabeprazole on the metabolic ratios of 2‚?źoxo‚?źclopidogrel/clopidogrel, H4 (the active metabolite of clopidogrel)/2‚?źoxo‚?źclopidogrel, and R‚?ź138727 (the active metabolite of prasugrel)/prasugrel thiolactone in human liver microsomes were determined. The antiplatelet activities of clopidogrel and prasugrel were measured with or without PPIs. As a result, most PPIs (except for pantoprazole) inhibited the formation of 2‚?źoxo‚?źclopidogrel with IC50 values of 20‚??32‚??őľM and inhibited the formation of H4 with IC50 values of 6‚??20‚??őľM. PPIs inhibited the formation of R‚?ź138727 with IC50 values of 9‚??...

Relative bioavailability and pharmacokinetic comparison of two different enteric formulations of omeprazole.

In this study, the test formulation of OPZ in fasting healthy Chinese male volunteers met the Chinese bioequivalance standard to the reference formulation based on AUC, C(max), and T(peak). PMID: 22556172 [PubMed - in process] (Source: J Zhejiang Univ Sci ...)

Proton pump (H(+)/K(+)-ATPase) inhibitors weaken the protective effect of alendronate on bone mechanical properties in estrogen-deficient rats.

Conclusion: Proton pump inhibitors weakened the protective effect of alendronate on bone mechanical properties in estrogen-deficient rats. PMID: 22814016 [PubMed - in process] (Source: Pharmacological Reports)

ZEGERID (Omeprazole, Sodium Bicarbonate) Powder, For Suspension ZEGERID (Omeprazole, Sodium Bicarbonate) Capsule [Santarus, Inc.]

Updated Date: Apr 26, 2012 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

Biological efficacy of a 600 mg loading dose of clopidogrel in ST-elevation myocardial infarction.

In conclusion, STEMI is associated with high on-treatment platelet reactivity following 600 mg of clopidogrel. The present results suggest that 600 mg of clopidogrel may not be able to achieve an optimal PR inhibition in STEMI patients undergoing PCI and more potent drugs may be preferred. PMID: 22535315 [PubMed - as supplied by publisher] (Source: Thrombosis and Haemostasis)<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>

[Effect of omeprazole on gene expression profile of human umbilical vein endothelial cell line and bioinformatics analysis].

CONCLUSION: Omeprazole modulates the function of endothelial cells by regulating the gene expression profiles of multiple pathways. PMID: 22543124 [PubMed - in process] (Source: Journal of Southern Medical University)

OMEPRAZOLE MAGNESIUMcapsule, Delayed Release [Dr. Reddy'S Laboratories Limited]

Updated Date: Apr 18, 2012 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

Lansoprazole/omeprazole: Hypomagnesaemia leading to seizures: case report

(Source: Reactions)

The effect of omeprazole and esomeprazole on the maintenance dose of phenprocoumon

© 2012 The Authors. British Journal of Clinical Pharmacology © 2012 The British Pharmacological Society (Source: British Journal of Clinical Pharmacology)<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>

A prospective randomized controlled trial to compare the effects of omeprazole and famotidine in preventing delayed bleeding and promoting ulcer healing after endoscopic submucosal dissection

Conclusions:‚?? PPIs are not superior to H2RAs for the prevention of delayed bleeding or the healing of artificially induced ulcers after ESD.¬© 2012 Journal of Gastroenterology and Hepatology Foundation and Blackwell Publishing Asia Pty Ltd (Source: Journal of Gastroenterology and Hepatology)

The effect of omeprazole and esomeprazole on the maintenance dose of phenprocoumon

© 2012 The Authors. British Journal of Clinical Pharmacology © 2012 The British Pharmacological Society (Source: British Journal of Clinical Pharmacology)

The influence of CYP2C19 genetic polymorphism on the pharmacokinetics/pharmacodynamics of proton pump inhibitor-containing Helicobacter pylori treatments.

Authors: Serrano DR, Torrado S, Torrado-Santiago S, Gisbert JP Abstract Proton pump inhibitors (PPIs) are the most potent acid suppressants available. PPIs undergo hepatic metabolism via the CYP2C system for the isoforms CYP2C19 and CYP3A4 in particular. Genetic polymorphisms in CYP2C19 may affect the metabolism of individual PPIs to different extents. Although PPIs are highly effective as a class, differences in their pharmacokinetics, such as bioavailability and metabolism, may translate into differences in clinical outcomes. In Helicobacter pylori infection, a significantly lower eradication rate was seen in extensive metabolisers with omeprazole but no with rabeprazole. PMID: 22493986 [PubMed - as supplied by publisher] (Source: Current Drug Metabolism)

Usefulness of antimicrobial susceptibility in the eradication of Helicobacter pylori

Conclusions:‚?? To perform culture and antimicrobial susceptibility of the H. pylori isolates was a strategy more successful and cost effective than empirical 10‚?źday OAC treatment in populations with high rates of resistance to clarithromycin.¬© 2012 The Authors Clinical Microbiology and Infection ¬© 2012 European Society of Clinical Microbiology and Infectious Diseases (Source: Clinical Microbiology and Infection)<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>

No consistent evidence of differential cardiovascular risk amongst proton-pump inhibitors when used with clopidogrel: Meta-analysis

Conclusions: The absence of consistent evidence on differential cardiovascular risk amongst PPIs (particularly regarding safety of pantoprazole) is in direct opposition to the platelet function and pharmacokinetic data. Our findings of increased cardiovascular risk with PPIs in the absence of clopidogrel suggest that confounding and bias are strong possibilities. The clinical validity or relevance of the hypothesized PPI-clopidogrel interaction remains questionable. (Source: International Journal of Cardiology)

Accumulating Evidence for a Drug-Drug Interaction Between Methotrexate and Proton Pump Inhibitors.

Conclusion. There is evidence to suggest that concomitant use of methotrexate (primarily at high doses) with PPIs such as omeprazole, esomeprazole, and pantoprazole may decrease methotrexate clearance, leading to elevated serum levels of methotrexate and/or its metabolite hydroxymethotrexate, possibly leading to methotrexate toxicities. In several case reports, no methotrexate toxicity was found when a histamine H(2) blocker was substituted for a PPI. Based on the reviewed data, the FDA updated the methotrexate label to include the possible drug-drug interaction between high-dose methotrexate and PPIs. Physicians should be alerted to this potential drug-drug interaction in patients receiving concomitant high-dose methotrexate and PPIs. PMID: 22477728 [PubMed - as supplied by publisher]...

Usefulness of antimicrobial susceptibility in the eradication of Helicobacter pylori

Conclusions:‚?? To perform culture and antimicrobial susceptibility of the H. pylori isolates was a strategy more successful and cost effective than empirical 10‚?źday OAC treatment in populations with high rates of resistance to clarithromycin.¬© 2012 The Authors Clinical Microbiology and Infection ¬© 2012 European Society of Clinical Microbiology and Infectious Diseases (Source: Clinical Microbiology and Infection)

A Randomized, 2-Period, Crossover Design Study to Assess the Effects of Dexlansoprazole, Lansoprazole, Esomeprazole, and Omeprazole on the Steady-State Pharmacokinetics and Pharmacodynamics of Clopidogrel in Healthy Volunteers

Conclusions: Generation of clopidogrel active metabolite and inhibition of platelet function were reduced less by the coadministration of dexlansoprazole or lansoprazole with clopidogrel than by the coadministration of esomeprazole or omeprazole. These results suggest that the potential of PPIs to attenuate the efficacy of clopidogrel could be minimized by the use of dexlansoprazole or lansoprazole rather than esomeprazole or omeprazole. (A Study of the Effects of Multiple Doses of Dexlansoprazole, Lansoprazole, Omeprazole or Esomeprazole on the Pharmacokinetics and Pharmacodynamics of Clopidogrel in Healthy Participants; NCT00942175) (Source: Journal of the American College of Cardiology)

131I gastric uptake with and without omeprazole in patients undergoing radioiodine therapy for differentiated thyroid carcinoma

Content Type Journal ArticleCategory Letter to the EditorPages 1-2DOI 10.1007/s00259-012-2104-1Authors Gabriel Castro, Nuclear Medicine Section, University of Chile Clinical Hospital, Santos Dumont 999, Independencia, Santiago de Chile, ChileIsabel Berrocal, Nuclear Medicine Section, University of Chile Clinical Hospital, Santos Dumont 999, Independencia, Santiago de Chile, ChileJaime Carmona, Nuclear Medicine Section, University of Chile Clinical Hospital, Santos Dumont 999, Independencia, Santiago de Chile, ChileJaviera Gonz√°lez, Nuclear Medicine Section, University of Chile Clinical Hospital, Santos Dumont 999, Independencia, Santiago de Chile, ChilePatricio Gonz√°lez, Nuclear Medicine Section, University of Chile Clinical Hospital, Santos Dumont 999, Independencia, Santiago de Chi...<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>

Interleukin-6 and cytochrome-P450, reason for concern?

Abstract&nbsp;&nbsp;Interleukin 6 (IL-6) plays a central role in the immunopathogenesis of rheumatoid arthritis (RA) and tocilizumab [TCZ] (an anti-IL-6 receptor antibody) has been shown to be effective in the treatment of the condition. As up-regulation of IL-6 reduces the activity of cytochrome P450 (CYP) enzymes, blockade of this cytokine may enhance CYP function. This may lead to reduced bioavailability of CYP-metabolized drugs. Due to the increasing use of TCZ, we undertook a systematic literature review to explore such interactions. Our search was conducted in MEDLINE, EMBASE, Web of Science, FDA and EMEA websites for in vitro and in vivo studies, clinical trials and reviews mentioning TCZ and CYP on the basis of the title and abstract. Appropriate articles were further screene...

Early effect of oral administration of omeprazole with mosapride as compared with those of omeprazole alone on the intragastric pH

Conclusions: In H. pylori -negative healthy male subjects, an oral dose of omeprazole 20 mg plus mosapride 5 mg increased the intragastric pH more rapidly than omeprazole 20 mg alone. (Source: BMC Gastroenterology)

New drug promises relief from aspirin-related ulcers

Pozen previously outlined plans to price the drug at about $1 a day, making it more expensive than the combination of aspirin, which sells for about $5 a month and omeprazole, available for $10-$15 monthly, Zacks analyst Jason Napodano told Reuters. (Source: Modern Medicine)

Monitoring trough voriconazole plasma concentrations in haematological patients: real life multicentre experience

The objective of this retrospective study was to evaluate results from voriconazole therapeutic drug monitoring (TDM) in haematological patients in routine clinical practice. Between 2005 and 2010, 1228 blood samples were obtained from 264 haematological patients (median 3 samples/patient; range 1‚??27) receiving voriconazole for targeted/preemptive treatment of invasive aspergillosis (IA) (46.3% of samples), empirical therapy (12.9%) or prophylaxis (40.8%). A high‚?źpressure liquid chromatography assay was used to analyse voriconazole concentrations. Clinical and laboratory data were analysed retrospectively. The median of the detected voriconazole plasma concentration was 1.00‚??őľg‚??ml‚??1 (range &lt;0.20‚??13.47‚??őľg‚??ml‚??1). Significant inter‚?ź and intra‚?źpatients variability of...

ZEGERID OTC (Omeprazole And Sodium Bicarbonate) Capsule [MSD Consumer Care, Inc.]

Updated Date: Mar 16, 2012 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

A difficult diagnosis: drug‚?źinduced subacute cutaneous lupus erythematosus (SCLE) triggered by omeprazole in a patient with pre‚?źexisting idiopathic SCLE

(Source: Clinical And Experimental Dermatology)

Improved Diabetes Control and Pancreatic Function in a Type 2 Diabetic after Omeprazole Administration

A 43-year-old man with type 2 diabetes, opposed to insulin use and poorly responsive to oral agents added sequentially over 6 years, was placed on 40&#x2009;mg omeprazole twice daily. A linear decline in daily fasting blood glucose was observed over the first two-month treatment, and his hemoglobin A1c was reduced from 11.9&#x25; to 8.2&#x25;, then sustained at 8.1&#x25; after four months. Glucose, insulin, and C-peptide response to a 2-hour glucose tolerance test were consistently improved across this time period, and calculated beta-cell mass increased by 67&#x25;. We believe these responses are consistent with activation or neogenesis of pancreatic beta cells, possibly through a gastrin-mediated mechanism. (Source: Advances in Urology)

Omeprazole: Hypomagnesaemia: case report

(Source: Reactions)

FDA warns on Severe Diarrhea from Prilosec: AttorneyOne.com Provides...

On February 8th, 2012 the U.S. FDA issued a warning on drugs called proton pump inhibitors (PPIs) ‚?? including Prilosec - that might increase the risk of a type of chronic diarrhea and lead to severe...(PRWeb March 05, 2012)Read the full story at http://www.prweb.com/releases/2012/3/prweb9245735.htm (Source: PRWeb: Medical Pharmaceuticals)<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>

Safety profile of enantiomers versus racemic mixture: it's the same?

Conclusion The profile of ADRs could differ for some drugs marketed as racemate and enantiomer form. Further studies would be necessary to confirm these data.© 2012 The Authors. British Journal of Clinical Pharmacology © 2012 The British Pharmacological Society (Source: British Journal of Clinical Pharmacology)

GOOD NEIGHBOR PHARMACY OMEPRAZOLE (Omeprazole) Tablet, Delayed Release [Amerisource Bergen]

Updated Date: Mar 6, 2012 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

The effect of once daily omeprazole and succinic acid (VECAM) vs once daily omeprazole on 24‚?źh intragastric pH

Conclusions & Inferences‚?? VECAM 40 and VECAM 20 were significantly better in maintaining intragastric pH‚??&gt;‚??4 during the nighttime than OMP 20‚??mg. Succinic acid eliminates the need for a subsequent meal for intragastric pH control by VECAM. (Source: Neurogastroenterology and Motility)

Ameliorative effects of Panax quinquefolium on experimentally induced reflux oesophagitis in rats.

Conclusions: The present data indicate that PQ protects against RE-induced oesophageal damage via a mechanism that inhibits the influx of inflammatory cell to oesophagus and a consequence excessive oxidative load, opening the avenue to its promising protective role in patients with gastroesophageal reflux disease (GERD). PMID: 22561630 [PubMed - in process] (Source: Indian J Med Res)<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>

Omeprazole: Hypomagnesaemia: case report

(Source: Reactions)

The effect of once daily omeprazole and succinic acid (VECAM) vs once daily omeprazole on 24‚?źh intragastric pH

Conclusions & Inferences‚?? VECAM 40 and VECAM 20 were significantly better in maintaining intragastric pH‚??&gt;‚??4 during the nighttime than OMP 20‚??mg. Succinic acid eliminates the need for a subsequent meal for intragastric pH control by VECAM. (Source: Neurogastroenterology and Motility)

Cardiovascular Outcomes Associated with Concomitant Use of Clopidogrel and Proton Pump Inhibitors in Patients of Acute Coronary Syndrome in Taiwan

CONCLUSION:Our study indicated no statistically significant increase in the risk of rehospitalization for ACS due to concurrent use of clopidogrel and PPIs overall. Among individual PPIs, only omeprazole was found to be statistically significantly associated with increased risk of rehospitalization for ACS.© 2012 The Authors. British Journal of Clinical Pharmacology © 2012 The British Pharmacological Society (Source: British Journal of Clinical Pharmacology)

Updated national IV monograph on Omeprazole

Source: Medusa Area: News An updated&#160; IV monograph on Omeprazole is now available from the NHS injectable medicines guide website (Medusa). Please see the link below for access (registration required). (Source: NeLM - News)<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>

Cardiovascular Outcomes Associated with Concomitant Use of Clopidogrel and Proton Pump Inhibitors in Patients of Acute Coronary Syndrome in Taiwan

CONCLUSION:Our study indicated no statistically significant increase in the risk of rehospitalization for ACS due to concurrent use of clopidogrel and PPIs overall. Among individual PPIs, only omeprazole was found to be statistically significantly associated with increased risk of rehospitalization for ACS.© 2012 The Authors. British Journal of Clinical Pharmacology © 2012 The British Pharmacological Society (Source: British Journal of Clinical Pharmacology)

Gaviscon(R) vs. Omeprazole in symptomatic treatment of moderate gastroesophageal reflux. A direct comparative randomised trial

Conclusion: Gaviscon(R) was non-inferior to omeprazole in achieving a 24-h heartburn-free period in moderate episodic heartburn, and is a relevant effective alternative treatment in moderate GERD in primary care.Trial registrationISRCTN62203233. (Source: BMC Gastroenterology)

Metformin-associated Lactic Acidosis Masquerading as Ischemic Bowel

A 69-year-old male inpatient on the psychiatric ward developed abdominal pain, nausea, non-bloody emesis, and diaphoresis shortly after eating. His medical history included depression, coronary artery disease, diabetes mellitus, and dyslipidemia. His medications included clopidogrel, gabapentin, glipizide, lisinopril, metformin, metoprolol, omeprazole, rosuvastatin, and sertraline. He denied overdosing on any medications. His vital signs were a heart rate of 74 beats/min, temperature of 36.2¬įC, respiratory rate of 24 breaths/min, and blood pressure of 82/52 mm Hg. The examination revealed decreased bowel sounds, voluntary guarding, and tenderness to palpation in the lower abdomen, which appeared out of proportion to the physical examination. A rectal examination revealed impacted stool an...

Enantioselective disposition of omeprazole, pantoprazole, and lansoprazole in a same Brazilian subjects group.

Authors: Cassiano NM, Oliveira RV, Bernasconi GC, Cass QB Abstract This work reports the result of the enantioselective disposition of pantoprazole, omeprazole, and lansoprazole in a same group of Brazilian health subjects. Ten nongenotyped healthy subjects were used for this study. Each subject received a single oral dose of 80 mg of pantoprazole, 40 mg of omeprazole, and 30 mg of lansoprazole, and the plasma concentrations of the enantiomers were measured for 8 h postdose. For pantoprazole and omeprazole, among the 10 volunteers investigated, only one volunteer (Subject # 4) presented higher plasma concentrations of the (+)-enantiomer than those of (-)-enantiomer. Nevertheless, the area under the concentration-time curve of the (+)-lansoprazole was higher than those the (-)-lanso...

Molecular mechanism of the anti-inflammatory activity of a natural diarylnonanoid, malabaricone C.

In this study, we explored its anti-inflammatory activity and investigated the underlying mechanism of the action. Mal C suppressed the microvascular permeability and the levels of tumor necrosis factor-őĪ, interleukin-1ő≤ and nitric oxide in the lipopolysaccharide (LPS)-administered mice. At a dose of 10mg/kg, it showed comparable anti-inflammatory activity as that of omeprazole (5mg/kg) and dexamethasone (50mg/kg). It also reduced the expression and activities of inducible nitric oxide synthase, cyclooxygenase-2, as well as the pro- vs anti-inflammatory cytokines ratio in the LPS-treated RAW macrophages. Mal C was found to inhibit LPS-induced NF-kB activation in RAW 264.7 cells by blocking the MyD88-dependent pathway. Mal C suppressed NF-őļB activation and iNOS promoter activity, which c...<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>

Acute therapy with intravenous omeprazole on caustic esophageal injury: a prospective case series

SUMMARYThe ingestion of caustic substances may result in significant esophageal injury. There is no standard treatment protochol for esophageal injury and most patients are treated with a proton pump inhibitor or H2 antagonist. However, there is no clinical study evaluating the efficacy of omeprazole for caustic esophageal injury. A prospective study of 13 adult patients (&gt;18 years of age) who were admitted to our hospital for caustic ingestion between May 2010 and June 2010 was conducted. Mucosal damage was graded using a modified endoscopic classification described by Zargar et‚??al. Patients were treated with a proton pump inhibitor and maintained without oral intake until their condition was considered stable. Patients received omeprazole 80 mg in bolus IV, followed by continuous in...

4 medication classes linked to 67% of drug-related hospitalizations

Adverse drug events are important preventable causes of hospitalization in older adults. 4 medications linked to 67% of drug-related hospitalizations Four medications or medication classes were implicated alone or in combination in 67% of hospitalizations: - warfarin, 33% - insulins, 14% - oral antiplatelet agents, 13% - oral hypoglycemic agents, 11% High-risk medications were implicated in only 1.2% of hospitalizations. 50% of these hospitalizations were among adults 80 years of age or older.&nbsp;65% of hospitalizations were due to unintentional overdoses. Classification of adverse reactions to drugs: "SOAP III" mnemonic (click to enlarge the image): Adverse drug reactions (ADRs) affect 10‚??20% of hospitalized patients and 25% of outpatients. Rule of 10s in ADR 10% of patien...

The effect of gastric acid suppression with pantoprazole on the efficacy of sevelamer hydrochloride as a phosphate binder in haemodialysis patients ‚?? A Pilot Study.

Conclusions:‚?? This pilot study demonstrates preliminary in vivo evidence for no effect of gastric acid suppression on the effectiveness of sevelamer HCL. Our results are limited by small sample size and therefore, larger experimental studies should be conducted. Although our study did not find a significant drug interaction, given the high prevalence of acid suppressant use in dialysis patients, physicians should be aware of the potential influence of acid suppression on the efficacy of phosphate binders and regularly assess the clinical need for acid suppression therapy.¬© 2012 The Authors. Nephrology ¬© 2012 Asian Pacific Society of Nephrology (Source: Nephrology)

Can a cocktail designed for phenotyping pharmacokinetics and metabolism enzymes in human be used efficiently in rat?

Authors: Videau O, Pitarque S, Troncale S, Hery P, Thévenot E, Delaforge M, Bénech H Abstract We recently designed the CIME cocktail consisting of 10 drugs to assess the activity of the major human CYPs (CYP1A2, CYP2C8, CYP2C9, CYP2C19, CYP2D6 and CYP3A), a phase II enzyme (UGT1A1/6/9), two drug transporters (P-gp and OATP1B1) and a component of the renal function ( Videau et al. 2010 ). The present work aimed at studying the usefulness of the CIME cocktail in the rat.The CIME cocktail was given per os to three male and three female rats, or incubated with rat liver microsomes. Parent substrates and metabolites were quantified by LC-MS/MS in plasma, urine and hepatic microsomal media, and phenotyping index were subsequently calculated.The CIME cocktail could therefore be used in ...

FDA Issues Warning on Acid Reflux Drugs

(MedPage Today) -- The FDA warned today that use of proton pump inhibitors -- including popular brands such as Nexium, Prilosec, and Prevacid -- may increase the risk of Clostridium difficile-associated diarrhea. (Source: MedPage Today Gastroenterology)<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>

Proton Pump Inhibitors (PPIs) - Drug Safety Communication: Clostridum Difficile-Associated Diarrhea (CDAD) Can be Associated With Stomach Acid Drugs

AcipHex (rabeprazole sodium)&nbsp; Dexilant (dexlansoprazole) &nbsp; Nexium (esomeprazole magnesium)? &nbsp; Omeprazole (omeprazole) Over-the-Counter (OTC) &nbsp; Prevacid (lansoprazole) and OTC Prevacid 24hr &nbsp; Prilosec (omeprazole)? and OTC... (Source: Drugs.com - Pharma News)

Induction of CYP2C19 and CYP3A Activity Following Repeated Administration of Efavirenz in Healthy Volunteers.

In conclusion, efavirenz enhances omeprazole metabolism in a nonstereoselective manner through induction of CYP3A and CYP2C19 activity. PMID: 22318618 [PubMed - as supplied by publisher] (Source: Clinical Pharmacology and Therapeutics)

Different effects of proton pump inhibitors and famotidine on the clopidogrel metabolic activation by recombinant CYP2B6, CYP2C19 and CYP3A4.

Authors: Ohbuchi M, Noguchi K, Kawamura A, Usui T Abstract Inhibitory potential of proton pump inhibitors (PPIs) and famotidine, an H(2) receptor antagonist, on the metabolic activation of clopidogrel was evaluated using recombinant CYP2B6, CYP2C19 and CYP3A4. Formation of the active metabolite from an intermediate metabolite, 2-oxo-clopidogrel, was investigated by liquid chromatography-tandem mass spectrometry and three peaks corresponding to the pharmacologically active metabolite and its stereoisomers were detected. Omeprazole potently inhibited clopidogrel activation by CYP2C19 with an IC(50) of 12.8 őľmol/L and more weakly inhibited that by CYP2B6 and CYP3A4. IC(50) of omeprazole for CYP2C19 and CYP3A4 was decreased about two- and three-fold, respectively, by 30-min prei...

New BMJ Study Reveals Prilosec Increases the Risk of Hip Fracture:...

On January 31st 2012, the British Medical Journey published a study revealing that postmenopausal women are at a 35% increased risk of hip fractures if they regularly use proton pump inhibitors (PPIs)...(PRWeb February 02, 2012)Read the full story at http://www.prweb.com/releases/2012/2/prweb9160947.htm (Source: PRWeb: Medical Pharmaceuticals)

Omeprazole: Hypomagnesaemia: case report

(Source: Reactions)<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>

The CCK2 receptor antagonist, JNJ‚?ź26070109, inhibits gastric acid secretion and prevents omeprazole‚?źinduced acid rebound in the rat

Conclusions and Implications.‚?? These studies demonstrated that chronic administration of JNJ‚?ź26070109 effectively inhibited gastric acid secretion and suppressed proton pump inhibitor (PPI)‚?źinduced acid rebound in the rat. This work advances the field by demonstrating that modest doses of a competitive CCK2 receptor antagonist have significant and functionally important anti‚?źtrophic actions in the gastric mucosa. These properties make JNJ‚?ź26070109 is a suitable candidate for clinical investigation for the treatment of GORD.¬© Janssen Research and Development LLC British Journal of Pharmacology ¬© The British Pharmacological Society (Source: British Journal of Pharmacology)

PRILOSEC (Omeprazole Magnesium) Capsule, Delayed Release PRILOSEC (Omeprazole Magnesium) Granule, Delayed Release [AstraZeneca LP]

Updated Date: Feb 2, 2012 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

The CCK2 receptor antagonist, JNJ‚?ź26070109, inhibits gastric acid secretion and prevents omeprazole‚?źinduced acid rebound in the rat

Conclusions and Implications.‚?? These studies demonstrated that chronic administration of JNJ‚?ź26070109 effectively inhibited gastric acid secretion and suppressed proton pump inhibitor (PPI)‚?źinduced acid rebound in the rat. This work advances the field by demonstrating that modest doses of a competitive CCK2 receptor antagonist have significant and functionally important anti‚?źtrophic actions in the gastric mucosa. These properties make JNJ‚?ź26070109 is a suitable candidate for clinical investigation for the treatment of GORD.¬© Janssen Research and Development LLC British Journal of Pharmacology ¬© The British Pharmacological Society (Source: British Journal of Pharmacology)

Omeprazole in Children With Healed Erosive EsophagitisOmeprazole in Children With Healed Erosive Esophagitis

Are proton pump inhibitors appropriate for children with erosive esophagitis? Alimentary Pharmacology & Therapeutics (Source: Medscape Today Headlines)

The effect of gastric acid suppression with pantoprazole on the efficacy of sevelamer hydrochloride as a phosphate binder in haemodialysis patients ‚?? A Pilot Study.

Conclusions:‚?? This pilot study demonstrates preliminary in vivo evidence for no effect of gastric acid suppression on the effectiveness of sevelamer HCL. Our results are limited by small sample size and therefore, larger experimental studies should be conducted. Although our study did not find a significant drug interaction, given the high prevalence of acid suppressant use in dialysis patients, physicians should be aware of the potential influence of acid suppression on the efficacy of phosphate binders and regularly assess the clinical need for acid suppression therapy.¬© 2012 The Authors. Nephrology ¬© 2012 Asian Pacific Society of Nephrology (Source: Nephrology)<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>

A new model of gastric bleeding induced in rats by aspirin plus clopidogrel under stimulation of acid secretion. Prophylactic effects of antiulcer drugs.

Authors: Takayama S, Izuhara C, Yamada N, Yamanaka S, Hashimoto E, Kaneko S, Takeuchi K Abstract We set up a new model of gastric bleeding induced by the luminal perfusion of aspirin (ASA) in rats pretreated with clopidogrel under conditions where acid secretion is stimulated, and examined the effect of antiulcer drugs on the bleeding. Under urethane anesthesia, acid secretion was stimulated by i.v. infusion of histamine (8 mg/kg/h), and two catheters were inserted into the stomach, one from the esophagus and another from the duodenum. The stomach was perfused with 25 mM ASA at a rate of 0.1 ml/min using an infusion pump, and gastric bleeding was measured as hemoglobin concentration in the perfusate collected every 15 min. Clopidogrel (30 mg/kg) was given orally 24 h before the per...

OMEPRAZOLE AND SODIUM BICARBONATEcapsule [Par Pharmaceutical Inc.]

Updated Date: Jan 30, 2012 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

TOPCARE OMEPRAZOLE (Omeprazole) Tablet, Delayed Release [Topco Associates LLC]

Updated Date: Jan 27, 2012 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

BERKLEY AND JENSEN OMEPRAZOLE (Omeprazole) Tablet, Delayed Release [BJWC]

Updated Date: Jan 27, 2012 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

PRILOSEC (Omeprazole Magnesium) Capsule, Delayed Release PRILOSEC (Omeprazole Magnesium) Granule, Delayed Release [AstraZeneca LP]

Updated Date: Jan 24, 2012 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>

Duration of Dual Amoxicillin Plus Omeprazole for H. Pylori Duration of Dual Amoxicillin Plus Omeprazole for H. Pylori

How long should a patient with H. pylori disease be treated with a combination of an antibiotic and a proton pump inhibitor? This new study investigates. Journal of Gastroenterology and Hepatology (Source: Medscape Today Headlines)

Unusual presentation of MALT lymphoma as diffuse gastric erythema

A 59-year-old white man was admitted with sudden onset of dysphagia, nausea, and vomiting. He had no abdominal pain, fever, night sweats, or weight loss. Physical examination and basic blood tests showed normal results. EGD revealed multiple distal esophageal ulcers ( ) and Candida esophagitis. The stomach and duodenum were unremarkable. There was no evidence of HIV, cytomegalovirus, or herpes simplex virus infection. His symptoms improved with acid suppression and antifungal therapy. EGD 2 months later revealed a normal esophagus and diffuse erythema in the gastric fundus and body resembling portal hypertensive gastropathy ( ). Gastric biopsy, however, showed MALT lymphoma ( ) with strong CD20 immunohistochemistry staining, but no evidence of Helicobacter pylori infection. A 10-day course...

OMEPRAZOLE/SODIUM BICARBONATE (Omeprazole, Sodium Bicarbonate) Powder, For Suspension OMEPRAZOLE/SODIUM BICARBONATE (Omeprazole, Sodium Bicarbonate) Capsule [Prasco, Laboratories]

Updated Date: Jan 11, 2012 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

Impact of antisecretory treatment on respiratory symptoms of gastroesophageal reflux disease in children

SUMMARYThe effect of antisecretory treatment on extraesophageal symptoms of gastroesophageal reflux disease was evaluated. Seventy‚?źeight children presenting with typical and extraesophageal symptoms of gastroesophageal reflux disease underwent a multichannel intraluminal impedance and pH monitoring (MII/pH). Children with a positive MII/pH were randomly treated with proton pump inhibitors (PPIs) or histamine H2‚?źreceptor antagonists (H2RAs) during 3 months. At the end of the treatment period, all patients were recalled. A second treatment period of 3 months was given to those patients who were not symptom‚?źfree after 3 months. Thirty‚?źfive of the forty‚?źone (85.4%) children with a pathologic MII/pH presented with extraesophageal symptoms and were treated with PPIs (omeprazole; n:19) ...

Influence of proton pump inhibitors on dexamethasone-induced gastric mucosal damage in rats

A. H. M. Viswanatha Swamy, M Sajjan, A. H. M. Thippeswamy, BC Koti, AJ SadiqIndian Journal of Pharmaceutical Sciences 2011 73(2):193-198The present study was designed to compare the curative role of proton pump inhibitors, omeprazole, rabeprazole and lansoprazole against dexamethasone-induced ulcer model. Dexamethasone (5 mg/kg/day) was used as an ulcerogen. Dexamethasone suspended in 1&#x0025; CMC in water was given orally to all rats. Omeprazole (20 mg/kg), rabeprazole (20 mg/kg), and lansoprazole (20 mg/kg) were administered by oral route 30 minutes prior to dexamethasone for ulcer protective studies, gastric secretion and mucosal studies. Effects of proton pump inhibitors were determined by the evaluation of various biochemical parameters such as estimation of myeloperoxidase, cortisol...

MEMBERS MARK OMEPRAZOLE (Omeprazole) Tablet, Delayed Release [Sam'S West Inc]

Updated Date: Jan 3, 2012 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

Early effects of oral administration of omeprazole and roxatidine on intragastric pH.

Conclusions: In Helicobacter pylori-negative healthy male subjects, oral administration of roxatidine 75 mg increased the intragastric pH more rapidly than that of omeprazole 20 mg. PMID: 22205617 [PubMed - in process] (Source: J Zhejiang Univ Sci ...)

---

Three boys with ultrasound-confirmed infantile hypertrophic pyloric stenosis presented with minimal electrolyte imbalance and mild clinical dehydration. All 3 had been treated for presumed gastroesophageal reflux with ranitidine for a period of 2 to 5 weeks. There was a limited biochemical response to ‚??resuscitation‚?Ě with half normal saline and 5% dextrose. Similar findings have been reported with patients on omeprazole, and 1 study has advocated cimetidine therapeutically in infantile hypertrophic pyloric stenosis to reduce the need for surgery. (Source: Journal of Pediatric Surgery)

Acute therapy with intravenous omeprazole on caustic esophageal injury: a prospective case series

SUMMARYThe ingestion of caustic substances may result in significant esophageal injury. There is no standard treatment protochol for esophageal injury and most patients are treated with a proton pump inhibitor or H2 antagonist. However, there is no clinical study evaluating the efficacy of omeprazole for caustic esophageal injury. A prospective study of 13 adult patients (&gt;18 years of age) who were admitted to our hospital for caustic ingestion between May 2010 and June 2010 was conducted. Mucosal damage was graded using a modified endoscopic classification described by Zargar et‚??al. Patients were treated with a proton pump inhibitor and maintained without oral intake until their condition was considered stable. Patients received omeprazole 80 mg in bolus IV, followed by continuous in...<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>

UP AND UP OMEPRAZOLE (Omeprazole) Tablet, Delayed Release [Target Corporation]

Updated Date: Dec 29, 2011 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

DG HEALTH OMEPRAZOLE (Omeprazole) Tablet, Delayed Release [Dolgencorp, LLC]

Updated Date: Dec 29, 2011 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

HEALTHY ACCENTS OMEPRAZOLE (Omeprazole) Tablet, Delayed Release [DZA Brands LLC]

Updated Date: Dec 29, 2011 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

BEING WELL OMEPRAZOLE (Omeprazole) Tablet, Delayed Release [Save-A-Lot Food Stores Ltd]

Updated Date: Dec 29, 2011 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

Blindness following severe midfacial trauma ‚?? Case report and review

Conclusion: The risk of blindness is higher than expected. Latest findings regarding the neuroprotective effects of erythropoetine or/and progesterone seem to promise a more successful treatment. (Source: Journal of Cranio-Maxillofacial Surgery)<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>

Med Sci Monit 2012; 18(1):BR9-15 &quot;Orally administered L-arginine and glycine are highly effective against acid reflux esophagitis in rats&quot;

Conclusions: The results confirmed an essential role for acid and pepsin in the pathogenesis of acid reflux esophagitis in the rat model and further suggested that various amino acids affect the severity of esophagitis in different ways, due to yet unidentified mechanisms; L-alanine and L-glutamine exert a deleterious effect on the esophagitis, while L-arginine and glycine are highly protective, independent of endogenous prostaglandins and nitric oxide. (Source: Medical Science Monitor)

Increasing the duration of dual amoxicillin plus omeprazole Helicobacter pylori eradication to 6‚??weeks: A pilot study

Conclusion:‚?? Despite the theory and pre‚?źexisting data from Japan, in the USA, prolonging the duration of dual amoxicillin‚?źPPI therapy did not improve treatment outcome in 90% or more of our patients. (Source: Journal of Gastroenterology and Hepatology)

Allergic reaction to proton pump ńĪnhibitor: Pantoprazole ńĪnduced Kounis syndrome

A 38-year-old male patient was admitted to our emergency department with the complaints of generalized pruritis, malaise, dyspnea and severe squeezing chest pain just starting 30min after taking an oral dose of 40mg pantoprazole for new onset gastroesophageal reflux. His past history was unremarkable for any allergic reaction, hypertension, diabetes mellitus or dyslipidemia. He was a nonsmoker. Physical examination revealed blood pressure of 110/80mmHg, pulse of 81 beats/min regular, oxygen saturation of 92% and also he had erythematous rash over the whole body without angioedema, he was sweating and pale. Initial electrocardiography (ECG) showed sinus rhythm and ST segment elevation in leads D2, D3, aVF compatible with acute inferior myocardial infarction (A). Medical management was admin...

Effect of Ginkgo biloba special extract EGb 761¬ģ on human cytochrome P450 activity: a cocktail interaction study in healthy volunteers

Conclusion&nbsp;&nbsp;EGb 761¬ģ has no relevant effect on the in vivo activity of the major CYP enzymes in humans and therefore has no relevant potential to cause respective metabolic drug‚??drug interactions. Content Type Journal ArticleCategory Clinical TrialPages 1-8DOI 10.1007/s00228-011-1174-5Authors G. Zadoyan, Department of Pharmacology Clinical Pharmacology Unit, University of Cologne, Gleueler Str. 24, 50931 Cologne, GermanyD. Rokitta, Department of Pharmacology Clinical Pharmacology Unit, University of Cologne, Gleueler Str. 24, 50931 Cologne, GermanyS. Klement, Dr. Willmar Schwabe GmbH & Co. KG, Karlsruhe, GermanyA. Dienel, Dr. Willmar Schwabe GmbH & Co. KG, Karlsruhe, GermanyR. Hoerr, Dr. Willmar Schwabe GmbH & Co. KG, Karlsruhe, GermanyT. Gramatt√©, Drug Developmen...

Synthesis and antiulcer activity evaluation of conjugates of amino acids with N-aroyl- N, N' -dicyclohexyl urea

Amino acids are safe molecules with variable efficacy against ulceration. Considering the good antioxidant potential of N-aroyl- N, N' -dicyclohexyl urea and antiulcer activities of amino acids, a series of amino acid conjugates of N-aroyl- N, N' -dicyclohexyl urea was synthesized and the effect against ulceration in albino rats induced by pyloric ligation was screened. All these compounds were found to be safe and active. Reduction of ulcer index was significant for all compounds. Conjugates of methionine and histidine exhibited enhanced antiulcer activity comparable to omeprazole in terms of inhibition of release of gastric juice, hydrochloric acid and neutralization activity. The promising efficacy and safety of these compounds is interesting for further investigation. (Source: Chemistr...<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>

Clopidogrel and proton pump inhibitors: is there a significant drug-drug interaction?

Authors: Shmulevich E, Friger M, Gilutz H, Azab AN Abstract Dual antiplatelet therapy with aspirin and clopidogrel is among the most efficacious treatment for patients after acute coronary syndromes and for those who have had a percutaneous coronary intervention and coronary stent implantation. Patients who are treated with dual antiplatelet therapy are usually also ordered medications that reduce the secretion of gastric acid (such as H2 receptor blockers or proton pump inhibitors [PPIs]) in order to decrease the risk of gastrointestinal bleeding and dyspepsia. Numerous observational studies reported that omeprazole (a PPI) attenuates the antiplatelet activity and clinical effectiveness of clopidogrel and causes adverse cardiovascular events. Based on these findings, several medic...

Optimal Management of Antiplatelet Therapy and Proton Pump Inhibition Following Percutaneous Coronary Intervention

Opinion statement&nbsp;&nbsp;Dual antiplatelet therapy (aspirin and a P2Y12 antagonist) is required after the insertion of a coronary artery stent. If the stent has been inserted in the context of an acute coronary syndrome (ACS), then clopidogrel or a high-potency P2Y12 antagonist such as prasugrel or ticagrelor should be considered. Current indications for the use of prasugrel in this situation include ST elevation, diabetes, or previous stent thrombosis on clopidogrel therapy. If the stent has been inserted electively for stable ischemic heart disease, then the patient should normally receive clopidogrel. Next, it is important to consider the patient‚??s bleeding risk. The CRUSADE score can be used to determine the likelihood of a subsequent gastrointestinal (GI) bleed. For patient...

Multicenter Prospective Trial of Hypofractionated Radiation Treatment, Toceranib, and Prednisone for Measurable Canine Mast Cell Tumors

Conclusions and Clinical ImportanceThe combination of hypofractionated RT, toceranib, and prednisone was tolerated and efficacious in the majority of dogs. Response rates and durations were higher than those reported for toceranib as a single‚?źagent treatment for MCT. This combination is a viable treatment option for unresectable MCT. (Source: Journal of Veterinary Internal Medicine)

Long‚?źterm maintenance treatment with omeprazole in children with healed erosive oesophagitis: a prospective study

Conclusions‚?? Remission of erosive oesophagitis is maintained with omeprazole treatment for at least 21‚??months in most children aged 1‚??16‚??years, and the drug is well tolerated. To maintain remission, some 60% of patients require more than half the dose required for healing. In children with GERD‚?źpredisposing conditions, GERD is often chronic and relapsing, and requires long‚?źterm management. (Source: Alimentary Pharmacology and Therapeutics)

ZEGERID (Omeprazole, Sodium Bicarbonate) Powder, For Suspension ZEGERID (Omeprazole, Sodium Bicarbonate) Capsule [Santarus, Inc.]

Updated Date: Dec 15, 2011 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>

Aspirin-induced small bowel injuries and the preventive effect of rebamipide.

CONCLUSION: Longer-term, low-dose aspirin administration induced damage in the small bowel. Rebamipide prevented this damage, and may be a candidate drug for treating aspirin-induced small bowel complications. PMID: 22171147 [PubMed - in process] (Source: World Journal of Gastroenterology)

EXCHANGE SELECT OMEPRAZOLE (Omeprazole) Tablet, Delayed Release [Army Air Force Exchange Service]

Updated Date: Dec 12, 2011 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

ZEGERID OTC (Omeprazole And Sodium Bicarbonate) Capsule [MSD Consumer Care, Inc.]

Updated Date: Dec 12, 2011 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

OMEPRAZOLE (Omeprazole) Capsule, Delayed Release [AvPAK]

Updated Date: Dec 8, 2011 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

KIRKLAND SIGNATURE OMEPRAZOLE (Omeprazole) Tablet, Delayed Release [Costco Wholesale Company]

Updated Date: Dec 5, 2011 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>

SMART SENSE OMEPRAZOLE (Omeprazole) Tablet, Delayed Release [Kmart Corporation]

Updated Date: Dec 5, 2011 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

Evaluation of antiulcerogenic activity of aqueous extract of Brassica oleracea var. capitata (cabbage) on Wistar rat gastric ulceration

CONCLUSIONS: The AEB demonstrated good antiulcerogenic activities which justify the inclusion of this plant in the management of gastric disorders. Further experiments are underway to determine which antiulcer mechanisms involved in gastroprotection.CONTEXTO: O repolho (Brassica oleracea var. capitata) √© uma planta de folhas herb√°ceas pertencente √† fam√≠lia Brassicaceae, nativa na costa sul e oeste da Europa. Usado na culin√°ria por seu valor nutritivo, possui conhecida atividade anti-inflamat√≥ria. OBJETIVO: Avaliar a atividade antiulcerog√™nica do extrato aquoso de Brassica oleracea var. capitata (AEB), a fim de validar os conhecimentos etnobot√Ęnico do uso da esp√©cie em dist√ļrbios g√°stricos. M√?TODO: √?lceras g√°stricas foram induzidas em ratos pela administra√ß√£o oral de √°cido ...

Pethidine/promethazine/omeprazole: Fixed drug eruption (first report with pethidine): case report

(Source: Reactions)

Helicobacter pylori Eradication in Functional Dyspepsia: HEROES Trial [Original Investigation]

Conclusion&nbsp; Helicobacter pylori eradication provided significant benefits to primary care patients with functional dyspepsia. Trial Registration&nbsp; clinicaltrials.gov Identifier: NCT00404534 (Source: Archives of Internal Medicine)

Gastroprotective effect of anti-cancer compound rohitukine: possible role of gastrin antagonism and H+ K+-ATPase inhibition

Abstract&nbsp;&nbsp;The present study was designed to evaluate the anti-ulcerogenic properties of an alkaloid chromane, rohitukine from Dysoxylum binectariferum. Anti-ulcer potential of rohitukine was assessed in cold restrained, pyloric ligated and ethanol induced ulcers in rats. In addition, rohitukine was tested in vitro for H+ K+-ATPase inhibitory activity in gastric microsomes. Moreover, we studied the role of rohitukine on the cytosolic concentration of Ca2+ in parietal cell-enriched cell suspension in order to ascertain its mechanism of action. Cytoprotective activity was evaluated through PGE2 level. Rohitukine significantly attenuated the ulcers in cold restraint ulcer (CRU) model in a dose-related manner. Moreover, it significantly lowered the free acidity and pepsin activity...<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>

Impact of pharmacotherapeutic warnings on the prescription of clopidogrel and proton pump inhibitors in hospitalised patients.

CONCLUSION: combined prescription has decreased since the first warning, above all in patients with a primary circulatory heart disease. Omeprazole is a potent CYP2C19 inhibitor, so it was used in lower rates than pantoprazole in association with clopidogrel. Medical departments related to cardiovascular disease followed the warning more than others. PMID: 22118768 [PubMed - as supplied by publisher] (Source: Farmacia Hospitalaria)

OMEPRAZOLE (Omeprazole) Capsule [Med-Health Pharma, LLC]

Updated Date: Nov 22, 2011 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

Anaphylaxis to lansoprazole with tolerance to omeprazole.

Authors: Aksu K, Kurt E PMID: 22115571 [PubMed - as supplied by publisher] (Source: Allergologia et Immunopathologia)

Assessment of the use of clopidogrel associated with gastroprotective medications in outpatients.

CONCLUSIONS: In our study, we did not evaluate the clinical status of the patients and the rates of reinfarction. And, as our study data showed, there are not any statistically differences between the groups that used clopidogrel associated with omeprazole, with ranitidine or that did not use any gastroprotective medication. PMID: 22115860 [PubMed - as supplied by publisher] (Source: Farmacia Hospitalaria)

OMEPRAZOLE/SODIUM BICARBONATE (Omeprazole, Sodium Bicarbonate) Powder, For Suspension OMEPRAZOLE/SODIUM BICARBONATE (Omeprazole, Sodium Bicarbonate) Capsule [Prasco, Laboratories]

Updated Date: Nov 21, 2011 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>

[Department of Error] Department of Error

Malfertheiner P, Bazzoli F, Delchier JC, et al. Helicobacter pylori eradication with a capsule containing bismuth subcitrate potassium, metronidazole, and tetracycline given with omeprazole versus clarithromycin-based triple therapy: a randomised, open-label, non-inferiority, phase 3 trial. Lancet 2011;377: 905‚??13‚??In this Article (March 12), the fourth sentence of the third paragraph in the Procedures section (p 906) should have read: ‚??In the 7-day standard regimen, one capsule of omeprazole, two of amoxicillin, and one of clarithromycin were taken twice daily (before morning and evening meals). (Source: LANCET)

PA32540 Plus Clopidogrel Dosed Separately Tops Standard Dual Antiplatelet Therapy With Delayed-Release Omeprazole For Platelet Inhibition

ORLANDO - Dual antiplatelet therapy (DAPT) with PA32540 and clopidogrel spaced 10 hours apart provides better platelet inhibition than concurrent administration of enteric-coated omeprazole (40 mg), enteric-coated aspirin (81 mg), and clopidogrel (300 mg loading/75 mg daily), according to results of the phase I Co-Rx study released at the American Heart Association (AHA) Scientific Sessions 2011. PA32540 is an investigational coordinated-delivery tablet of immediate-release omeprazole (40 mg), a proton pump inhibitor, layered around enteric-coated aspirin (325 mg)... (Source: Health News from Medical News Today)

Clopidogrel and PPI Interaction: Clinically Relevant or Not?

Abstract&nbsp;&nbsp;Proton pump inhibitors and clopidogrel are commonly prescribed medications, both alone and in combination. In January of 2009 the US Food and Drug Administration and the European Medicines Agency issued warnings with regard to the concomitant use of clopidogrel and proton pump inhibitors. Later that year, these warnings were limited to the proton pump inhibitor omeprazole. These warnings were largely based on in-vitro studies and observational analyses suggesting decreased efficacy of clopidogrel in the presence of proton pump inhibitors. Recent literature has suggested there may not be a clinically meaningful interaction. Content Type Journal ArticleCategory New Therapies for Cardiovascular Disease (KW Mahaffey, Section Editor)Pages 1-10DOI 10.1007/s11886-011-...

GOOD SENSE OMEPRAZOLE (Omeprazole) Tablet, Delayed Release [L Perrigo Company]

Updated Date: Nov 14, 2011 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

Evaluation of lansoprazole as a probe for assessing cytochrome P450 2C19 activity and genotype‚??phenotype correlation in childhood

Conclusion&nbsp;&nbsp;According to our results from a Turkish pediatric population, lansoprazole is a suitable probe drug for phenotyping CYP2C19. The CYP2C19*2 and *17 variants should be taken into consideration in predicting the clinical outcome of therapy with lansoprazole in the pediatric population. Content Type Journal ArticleCategory PharmacogeneticsPages 1-8DOI 10.1007/s00228-011-1151-zAuthors Ersin Gumus, Department of Pharmacology, Faculty of Medicine, Hacettepe University, Sihhiye, Ankara, TurkeyOzgur Karaca, Department of Pharmacology, Faculty of Medicine, Hacettepe University, Sihhiye, Ankara, TurkeyMelih O. Babaoglu, Department of Pharmacology, Faculty of Medicine, Hacettepe University, Sihhiye, Ankara, TurkeyGökhan Baysoy, Pediatric Gastroenterology, Hepatology...<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>

CARE ONE OMEPRAZOLE (Omeprazole) Tablet, Delayed Release [American Sales Company]

Updated Date: Nov 8, 2011 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

Acid inhibition effect of ilaprazole on Helicobacter pylori‚?źnegative healthy volunteers: an open randomized cross‚?źover study

Conclusion:‚?? Low dose of ilaprazole offers a comparable gastric acid inhibition to routine dose omeprazole, which is expected to be further tested in the acid‚?źassociated diseases patients. (Source: Chinese Journal of Digestive Diseases)

Are Acid Reflux Drugs Overused?

Many people who take popular antacid pills like Aciphex, Dexilant, Nexium, Prevacid, Prilosec, and Protonix don't need them, according to a series of studies presented here at the American College of Gastroenterology's annual meeting. (Source: WebMD Health)

Pharmacodynamic Evaluation of Clopidogrel Plus PA32540: The Spaced PA32540 With Clopidogrel Interaction Gauging (SPACING) Study.

Authors: Gurbel PA, Bliden KP, Fort J, Zhang Y, Plachetka JR, Antonino M, Gesheff M, Tantry US Abstract PA32540 combines 325 mg enteric-coated (EC) aspirin (ASA) with 40 mg immediate-release omeprazole; its influence on the antiplatelet effect of clopidogrel (C) is unknown. In this randomized, open-label study, subjects (n = 30) were treated with (i) 300 mg C + 325 mg ECASA followed by 75 mg C + 325 mg ECASA on days 2-7, (ii) 300 mg C + PA32540 followed by 75 mg C + PA32540 on days 2-7, or (iii) PA32540 in the morning + 300 mg C 10 h later on day 1 and PA32540 in the morning + 75 mg C 10 h later on days 2-7. We analyzed the noninferiority of PA32540 relative to ECASA, as defined by the upper bound of the 95% confidence interval ‚?§10% for the difference in least-square means of pla...

Efficacy of adding sodium alginate to omeprazole in patients with nonerosive reflux disease: a randomized clinical trial

In conclusion, omeprazole combined with sodium alginate was better than omeprazole alone in Japanese patients with NERD. (Source: Diseases of the Esophagus)<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>

Antibiotic susceptibility and intracellular localization of Diplorickettsia massiliensis

AbstractDiplorickettsia massiliensis is an obligate intracellular bacterium from the Coxiellaceae family recently isolated from Ixodes ricinus ticks. The inhibitory effects of antimicrobial agents were assessed by two different methods, Immunofluorescence and Gimenez staining assay. Different markers (EEA1, Lamp‚?ź1, capthepsin D and LysoTracker Red DND99) were used to reveal the nature of the vacuole containing the bacterium. Ciprofloxacin, levofloxacin and rifampin had MIC values of 2 őľg/ml. We found that 4őľg/ml of Doxycycline inhibited the growth of D. massiliensis strain. Surprisingly, D. massilensis was resistant to chloramphenicol up to the concentration of 64őľg/ml. We found that Penicillin G, Ammonium chloride, Gentamycin, Omeprazole, Bafilomycin A1 and Chloroquine were not activ...

Esomeprazole, Not Rosuvastatin, Affects Clopidogrel Post-PCIEsomeprazole, Not Rosuvastatin, Affects Clopidogrel Post-PCI

Esomeprazole is 'at least as bad' as omeprazole in reducing antiplatelet effects of clopidogrel, but SPICE found no differences between rosuvastatin and atorvastatin on platelet function. Heartwire (Source: Medscape Today Headlines)

Over-Prescription of Acid-Suppressing Medications in Infants: How It Came About, Why It‚??s Wrong, and What to Do About It

It has been almost 20 years since proton pump inhibitors (PPIs) were initially shown to be effective, safe, and well-tolerated for the short-term treatment of gastroesophageal reflux disease (GERD) in children over 1 year of age; GERD diagnosed on the basis of symptoms and hard diagnostic evidence of erosive esophagitis seen at endoscopy. In these studies, mostly performed in children 2 to 17 years of age, PPIs were shown to effectively treat symptoms and erosive esophagitis that were refractory to histamine-2-receptor antagonists (H2RA), buffering agents, prokinetics, and in some subjects, antireflux surgery. Subsequent to those studies with omeprazole, other PPIs were found to be similarly effective. Efficacy and safety were also shown for maintenance of remission of chronic, relapsing e...

FORMU CARE OMEPRAZOLE (Omeprazole) Tablet, Delayed Release [Access Business Group LLC]

Updated Date: Oct 19, 2011 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>

PRILOSEC OTC (Omeprazole Magnesium) Tablet, Delayed Release [Physicians Total Care, Inc.]

Updated Date: Oct 19, 2011 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

Omeprazole limited sampling strategies to predict area under the concentration‚??time curve ratios: implications for cytochrome P450 2C19 and 3A phenotyping

Conclusions&nbsp;&nbsp;A LSS model to predict AUCOPZ/AUC5OH, and thus CYP2C19 activity, was generated for Caucasian CYP2C19*1/*1 subjects. However, additional model validation is needed prior to general use. LSS models to predict AUCOPZ/AUCSUL, and thus CYP3A activity, were not possible, even upon stratification by CYP2C19 genotype and ethnicity. Content Type Journal ArticleCategory Pharmacokinetics and DispositionPages 1-7DOI 10.1007/s00228-011-1136-yAuthors Eileen B. Lawson, Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California, San Diego (UCSD), 9500 Gilman Drive, MC 0714, La Jolla, CA 92093-0714, USAJerry C. Wu, Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California, San Diego (UCSD), 9500 Gilman Drive, MC 0714, La Jolla, CA...

Antiprotozoal activity of proton-pump inhibitors.

Authors: Pérez-Villanueva J, Romo-Mancillas A, Hernández-Campos A, Yépez-Mulia L, Hernández-Luis F, Castillo R Abstract Parasitic diseases are still a major health problem in developing countries. In our effort to find new antiparasitic agents, in this Letter we report the in vitro antiprotozoal activity of omeprazole, lansoprazole, rabeprazole and pantoprazole against Trichomonas vaginalis, Giardia intestinalis and Entamoeba histolytica. Molecular modeling studies were an important tool to highlight the potential antiprotozoal activity of these drugs. Experimental evaluations revealed a strong activity for all compounds tested. Rabeprazole and pantoprazole were the most active compounds, having IC(50) values in the nanomolar range, which were even better than metronidazole, th...

AstraZeneca Says 400 Jobs to be Cut

From Philadelphia Inquirer (PA) (October 6, 2011) Oct. 06--AstraZeneca P.L.C., the global pharmaceutical giant that makes well-known medicines such as Prilosec, Nexium and Seroquel, said Thursday that it will cut about 400 U.S. jobs, with most... (Source: Drugs.com - Pharma News)

OMEPRAZOLE/SODIUM BICARBONATE (Omeprazole, Sodium Bicarbonate) Powder, For Suspension OMEPRAZOLE/SODIUM BICARBONATE (Omeprazole, Sodium Bicarbonate) Capsule [Prasco, Laboratories]

Updated Date: Oct 7, 2011 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>

ZEGERID (Omeprazole, Sodium Bicarbonate) Powder, For Suspension ZEGERID (Omeprazole, Sodium Bicarbonate) Capsule [Santarus, Inc.]

Updated Date: Oct 4, 2011 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

Carbamazepine/cilostazol/omeprazole interaction: First report of an interaction, leading to fatal toxic epidermal necrolysis in an elderly patient: case report

(Source: Reactions)

Effects of melatonin and tryptophan on healing of gastric and duodenal ulcers with Helicobacter pylori infection in humans.

In this study three groups A, B and C, each including 7 H. pylori-positive patients with gastric ulcers and 7 H. pylori-positive patients with duodenal ulcers, aging 28-50 years, were randomly assigned for the treatment with omeprazole 20 mg twice daily combined with placebo (group A), MT administered in a dose of 5 mg twice daily (group B) or TRP applied in a dose of 250 mg twice daily (group C). All patients underwent routine endoscopy at day 0 during which the gastric mucosa was evaluated and gastric biopsies were taken for the presence of H. pylori and histopathological evaluation. The rate of ulcer healing was determined by gastroduodenoscopy at day 0, 7, 14 and 21 after the initiation of the therapy. Plasma MT, gastrin, ghrelin and leptin were measured by specific RIA. At day 21, all...

How To Treat GERD

Your physician will usually suggest certain lifestyle modifications and dietary changes first. If you continue to have symptoms after these modifications, your physician will discuss with you the use of antacids neutralize stomach acid (which includes Rolaids, Maalox, Mylanta, Tums, and Gaviscon), H2 blockers (which includes Tagamet, Pepcid, Zantac, and Axid), and Proton Pump Inhibitors (PPIs) (which includes Prilosec, Prevacid, Nexium, Aciphex, and Protonix). If your physician and you decide a surgical option is needed, the most common surgical treatment for GERD is the fundoplications surgery. Another procedure sometimes used in the treatment of GERD is the radiofrequency treatment.How To Treat GERD originally appeared on About.com Heartburn / GERD on Friday, September 30th, 2011 at 00:2...

OMEPRAZOLE (Omeprazole) Tablet, Delayed Release [Dexcel Pharma Technologies Ltd.]

Updated Date: Sep 27, 2011 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>

Research Says PPIs Increase Risk of Developing C. diff

In a study conducted in Japan, researchers concluded that patients taking proton pump inhibitors (Aciphex, Dexilant, Nexium, Prevacid, Prilosec, and Protonix) were over three times more likely than other patients to develop C. diff. Researchers analyzed data from approximately 500 hospitalized patients. While there may be an increased risk of developing C. diff when taking PPIs, the risk for any person developing this infection is still relatively low. The study showed 19 of 487 PPI users developed C. diff, whereas 4 of 329 patients not taking PPIs developed this infection. How could PPIs increase the risk of C. diff? It is theorized that since PPIs lower stomach acidity, this could allow C. diff in the digestive system to survive when it wouldn't otherwise. While this study doesn...

Fixed drug eruption caused by three unrelated drugs: promethazine, pethidine and omeprazole

We report a case of fixed drug eruption (FDE) caused by three unrelated drugs. A 52‚?źyear‚?źold woman presented with a diagnosis of FDE after taking a drug to treat a common cold. An oral provocation test and a patch test were carried out, and the patient reacted to promethazine, which is a derivative of phenothiazine. To determine the core structure of the antigen, we performed patch testing and/or an oral provocation testing with six drugs that are similar in structure to promethazine. The patient reacted to five of the six drugs, and the antigenic determinant was identified as a phenothiazine and a tricyclic structure. The patient had similar eruptions at the same sites 3‚??years later after taking pethidine. Seven months after that reaction, a more severe eruption was caused by oral o...

Improvement in health-related quality of life after therapy with omeprazole in patients with coronary artery disease and recurrent angina-like chest pain. A double-blind, placebo-controlled trial of the SF-36 survey.

Conclusions: A double dose of omeprazole improved the general HRQL in patients with CAD without severe gastrointestinal symptoms more effectively than the placebo. (Source: Health and Quality of Life Outcomes)

Some Acid Reflux Drugs Linked to C. diff

The popular class of acid reflux medication that includes Aciphex, Dexilant, Nexium, Prevacid, Prilosec, and Protonix is associated with an increased risk of diarrhea caused by the bug Clostridium difficile (C. diff). (Source: WebMD Health)

Alfacalcidol/omeprazole: Hypokalaemia in elderly patients: 2 case reports

(Source: Reactions)

Impact of Gastric Acid‚??Suppressing Therapies on Platelet Reactivity in Patients With Coronary Artery Disease Treated With Clopidogrel: Results of a Pharmacodynamic Study

Drugs interacting with hepatic cytochrome P450 (CYP) enzymatic activity can reduce clopidogrel-induced pharmacodynamic (PD) effects (). In particular, the proton pump inhibitor (PPI)‚??clopidogrel interaction is a drug-specific effect involving PPIs interfering with CYP2C19 activity (e.g., omeprazole) (). Although the clinical implications of this interaction remain controversial (), these PD findings have prompted drug-regulating authorities to issue a warning for the use of these drugs (). Non-PPI gastric acid‚??suppressing strategies such as using H2 receptor antagonists (H2RAs) are treatment alternatives to PPIs (). H2RAs may also be differentiated according to their CYP2C19 effects, whereas cimetidine, but not ranitidine, inhibits CYP2C19 activity and should be avoided in clopidogrel-...

Addition of omeprazole to dual antiplatelet therapy with clopidogrel plus aspirin lowers the risk of upper gastrointestinal bleeding

Context Antiplatelet therapy represents the mainstay of treatment for patients undergoing percutaneous coronary intervention.1 However, an increased risk for gastrointestinal bleeding is associated with use of aspirin and clopidogrel. To reduce the bleeding risk, proton pump inhibitors (PPIs) are prescribed in combination with platelet inhibitors, a strategy that is recommended by existing consensus guidelines2 though no randomised trial has proved this. Recently, a pharmacodynamic drug&ndash;drug interaction has been shown for clopidogrel and omeprazole but not for pantoprazole.3 4 Whether this interaction has an impact on patient outcomes has not been investigated in a randomised trial. Methods Clopidogrel and the Optimization of Gastrointestinal Events (COGENT) was a randomised, double-...

Synthesis and antigastric ulcer activity of novel 5-isoproyl-3,8-dimethylazulene derivatives.

Authors: Zhang LY, Yang F, Shi WQ, Zhang P, Li Y, Yin SF Abstract 5-Isoproyl-3,8-dimethylazulene derivatives were synthesized and evaluated for antigastric ulcer activity in vivo. Some of them possess the best activity against gastric ulcer with ulcer index values lower than the drug reference (omeprazole). The structure-activity relationship (SAR) shows that the lipophilic flat structure contributes to quite potent antigastric ulcer activity. PMID: 21885274 [PubMed - in process] (Source: Bioorganic and Medicinal Chemistry Letters)

EQUATE OMEPRAZOLE DELAYED RELEASE (Omeprazole) Tablet, Delayed Release [Wal-Mart Stores Inc]

Updated Date: Sep 13, 2011 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>

Ligand-independent activation of the arylhydrocarbon receptor by ETK (Bmx) tyrosine kinase helps MCF10AT1 breast cancer cells to survive in an apoptosis-inducing environment

Biological Chemistry 392 (10): 897-908 Abstract It has been reported that the arylhydrocarbon receptor (AHR) is overexpressed in certain types of breast tumors. However, so far no concrete evidence has been provided yet as to why and how the overexpressed AHR in those cancer cells is functionally activated without exogenous ligands. Here we show that the AHR was functionally activated when estrogen receptor-negative, AHR overexpressing MCF10AT1 human breast cancer cells (designated P20E) were subjected to serum starvation. Transfection of cells with ETK-KQ, a plasmid for kinase-dead epithelial and endothelial tyrosine kinase (ETK), attenuated this AHR activation. Artificial over-expression of ETK in P20E cells through transfection with wild-type ETK plasmid (ETK-wt) caused up-regulation of...

OMEPRAZOLE (Omeprazole) Capsule, Delayed Release [AvPAK]

Updated Date: Sep 9, 2011 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

Luciferin IPA-Based Higher Throughput Human Hepatocyte Screening Assays for CYP3A4 Inhibition and Induction

The authors report here higher throughput screening (HTS) assays for the evaluation of CYP3A4 inhibition and CYP3A4 induction in human hepatocytes using a novel CYP3A4 substrate, luciferin IPA (LIPA). Using human recombinant CYP450 isoforms, LIPA was found to be metabolized extensively by CYP3A4 but not by CYP1A2, CYP2C9, CYP2C19, CYP2D6, or CYP2E1. In the 384-well plate CYP3A4 inhibition assay, the known inhibitors 1-aminobenzotriazole, erythromycin, ketoconazole, and verapamil were found to cause extensive (maximum inhibition of &gt;80%), dose-dependent, statistically significant inhibition of LIPA metabolism. The non-CYP3A4 inhibitors diethyldithiocarbamate, quercetin, quinidine, sulfaphenazole, ticlopidine, and tranylcypromine were found to have substantially lower (maximum inhibition ...

Omeprazole Impairs the Absorption of Mycophenolate Mofetil But Not of Enteric-Coated Mycophenolate Sodium in Healthy Volunteers.

Authors: Kees MG, Steinke T, Moritz S, Rupprecht K, Paulus EM, Kees F, Bucher M, Faerber L Abstract In 2 crossover studies, 12 healthy volunteers (6 male/6 female) received a single oral dose of mycophenolate mofetil (MMF) 1000 mg or an equimolar dose of enteric-coated mycophenolate sodium (EC-MPS) 720 mg fasting with and without coadministered omeprazole 20 mg bid. The plasma concentrations of mycophenolic acid (MPA) and of the inactive metabolite mycophenolic acid glucuronide (MPA-G) were measured by high-performance liquid chromatography (HPLC). In addition, dissolution of MMF 500 mg or EC-MPS 360 mg tablets was determined using an USP paddle apparatus in aqueous buffer of pH 1 to 7. The bioavailability of MPA following administration of MMF or EC-MPS was similar except for the ...

ZEGERID (Omeprazole, Sodium Bicarbonate) Powder, For Suspension ZEGERID (Omeprazole, Sodium Bicarbonate) Capsule [Santarus, Inc.]

Updated Date: Sep 6, 2011 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>

Persistence of Fetal Hemoglobin Expression in an Older Child with Trisomy 13

A delayed fetal-to-adult hemoglobin switch occurs in infants with trisomy 13. The level of fetal hemoglobin (HbF) has been assessed in very few children with trisomy 13 surviving past infancy. A 4-year-old female with trisomy 13 confirmed by karyotype and chromosomal microarray analysis was followed by our complex care service. The patient had developmental delay, a seizure disorder, frequent aspiration requiring gastrostomy tube placement and feedings, and recurrent urinary and respiratory tract infections. She had undergone repair of a cleft palate, umbilical hernia, and polydactyly. She was maintained on a medication regimen of omeprazole, nitrofurantoin, melatonin, and levetiracetam. (Source: The Journal of Pediatrics)

Cocktail Approach for In Vivo Phenotyping of 5 Major CYP450 Isoenzymes: Development of an Effective Sampling, Extraction, and Analytical Procedure and Pilot Study With Comparative Genotyping.

In this study, the authors developed a phenotyping method for CYP1A2, 2C9, 2C19, 2D6, and 3A4 using a cocktail of 100 mg caffeine, 125 mg tolbutamide, 20 mg omeprazole, 30 mg dextromethorphan, and 2 mg midazolam. A simple sampling scheme was established collecting 3 blood samples at 0, 4, and 24 hours followed by solid-phase extraction and liquid chromatography/tandem mass spectrometry analysis. After addition of 8 deuterated internal standards and extraction, the analytes were separated using gradient elution with ammonium acetate and methanol. Data acquisition was performed on a triple quadrupole linear ion trap mass spectrometer in multiple-reaction monitoring mode with positive electrospray ionization. The assay was validated according to international guidelines: limits of quantificat...

[Clinical importance of the clopidogrel - omeprazole interaction: a question to solve.]

Authors: Amariles P, Holguín H, Ceballos M PMID: 21885164 [PubMed - as supplied by publisher] (Source: Atencion Primaria)

Aryl Hydrocarbon Receptor and Aryl Hydrocarbon Nuclear Translocator Expression in Human and Rat Placentas and Transcription Activity in Human Trophoblast Cultures

In conclusion, we describe expression and ontogeny of AHR/Ahr and ARNT/Arnt and systematically characterize induction of major AHR target genes in human placental trophoblast forming the placental maternal-fetal morphological and metabolic barrier. (Source: Toxicological Sciences)

Omeprazole: Hypomagnesaemia in an elderly patient: case report

(Source: Reactions)<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>

Repeated administration of berberine inhibits cytochromes P450 in humans

Conclusions&nbsp;&nbsp;Repeated administration of berberine (300&nbsp;mg, t.i.d., p.o.) decreased CYP2D6, 2C9, and CYP3A4 activities. Drug-drug interactions should be considered when berberine is administered. Content Type Journal ArticleCategory Short CommunicationPages 1-5DOI 10.1007/s00228-011-1108-2Authors Ying Guo, Pharmacogenetics Research Institute, Institute of Clinical Pharmacology, Central South University, XiangYa School of Medicine, 110 Xiang-Ya Road, Changsha, Hunan 410078, People‚??s Republic of ChinaYao Chen, Pharmacogenetics Research Institute, Institute of Clinical Pharmacology, Central South University, XiangYa School of Medicine, 110 Xiang-Ya Road, Changsha, Hunan 410078, People‚??s Republic of ChinaZhi-rong Tan, Pharmacogenetics Research Institute, Institute...

Proton Pump Inhibitors Should Have Black-box Warnings, Group Tell FDA

Withdrawal from PPIs (proton pump inhibitors) can lead to severe rebound acid secretion, a complication that can force users to become dependent on them - this should be mentioned in a black-box warning, consumer group Public Citizen has told the FDA (Food and Drug Administration). Examples of PPIs include, Dexilant, Vimovo, Prilosec OTC, Prevacid 24-Hr, Zegerid, Zegerid OTC, Prevacid, Nexium, , Prilosec, Protonix, and Aciphex. Proton Pump Inhibitors, also known as PPIs, are drugs which reduce gastric acid production. They are the most powerful acid secretion inhibitors available today... (Source: Health News from Medical News Today)

Omeprazole attenuates hyperoxic injury in H441 cells via the aryl hydrocarbon receptor.

In this study, we tested the hypothesis that omeprazole attenuates hyperoxia-induced cytotoxicity, ROS generation, and expression of monocyte chemoattractant protein-1 (MCP-1) in human lung-derived H441 cells via AhR activation. Experimental groups included cells transfected with AhR small interfering RNA (siRNA). Hyperoxia resulted in significant increases in cytotoxicity, ROS generation, and MCP-1 production, which were significantly attenuated with the functional activation of AhR by omeprazole. The protective effects of omeprazole on cytotoxicity, ROS production, and MCP-1 production were lost in H441 cells whose AhR gene was silenced by AhR siRNA. These findings support the hypothesis that omeprazole protects against hyperoxic injury in vitro via AhR activation that is associated with...

A clinically significant interaction between tacrolimus and multiple proton pump inhibitors in a kidney transplant recipient

Maguire M, Franz T, Hains DS. A clinically significant interaction between tacrolimus and multiple proton pump inhibitors in a kidney transplant recipient. ‚?®Pediatr Transplantation 2011. ¬© 2011 John Wiley & Sons A/S.Abstract:‚?? The shared metabolism of PPIs and tacrolimus through the CYP enzyme system has been associated with clinically significant drug interactions, especially in patients who are classified as CYP 2C19 PMs. However, existing data are conflicting, indicating that a single mechanism does not account for all interactions. A drug interaction between tacrolimus and omeprazole, esomeprazole, but not lansoprazole, occurred in an 18‚?źyr‚?źold female kidney transplant recipient classified as a CYP 2C19 extensive (normal) metabolizer. This case suggests that further resear...

Watchdog Group Asks For Black Box Warning for PPIs

The watchdog group Public Citizen, in a petition filed on Aug 23rd, 2011, is asking the FDA to implement a black box warning for proton pump inhibitors (PPIs). This is in light of various studies that have shown several side effects, and the potential for patients to become dependent on these drugs. "These drugs are being prescribed far too commonly to people who shouldn't be taking them," said Dr. Sidney Wolfe, director of Public Citizen's Health Research Group. "As a result, millions of people are needlessly setting themselves up to become dependent on PPIs while exposing themselves to the serious risks associated with long-term therapy." Some of the risks of using PPIs cited in the petition can include: wrist, hip, and spine fractures can lead to some infections, such as pneum...

Small-molecular virulence inhibitors show divergent and immunomodulatory effects in infection models of Salmonella enterica serovar Typhimurium

Abstract: The virulence-associated Salmonella pathogenicity island 2 (SPI2) type III secretion system supports intracellular replication of Salmonella enterica serovar Typhimurium in macrophage-like RAW264.7 cells. In contrast, the salicylidene acylhydrazide INP0010 and the benzimidazole omeprazole prevent virulence factor-mediated replication of S. Typhimurium in these cells. Here we show that INP0010 enhances expression of inducible nitric oxide synthase (iNOS), nitric oxide (NO) production, the oxidative burst and tumour necrosis factor-alpha (TNFőĪ) release in infected RAW264.7 cells. INP0010 also inhibited SPI2 activity in RAW264.7 cells. The ability of INP0010 to suppress bacterial intracellular replication correlated with NO production. The iNOS inhibitor N-monomethyl-l-arginine res...

Relationship between cardiovascular outcomes and proton pump inhibitor use in patients receiving dual antiplatelet therapy after acute coronary syndrome

ConclusionIn conclusion, this population‚?źbased cohort study found that concomitant use of clopidogrel and PPI in patients who received dual antiplatelet therapy after ACS was not associated with risk of ACS re‚?źhospitalization. Together, our study and findings of recently published clinical trials suggest that there was no apparent CV interaction between clopidogrel and PPI in patients who received dual antiplatelet therapy. Copyright ¬© 2011 John Wiley & Sons, Ltd. (Source: Pharmacoepidemiology and Drug Safety)

Letter: Drug regulatory agencies' role in the interaction between clopidogrel and proton pump inhibitors

Source: The American Journal of Gastroenterology Area: News The authors of this letter discuss the role of regulatory agencies, such as the Food and Drug Administration and the European Medicines Agency, in providing recommendations on the management of the interaction between clopidogrel and proton pump inhibitors (PPIs). The authors note that clear differences can be found between the statements given by the different agencies and the conclusions made. They suggest that current guidelines which discourage the concomitant use of either omeprazole or esomeprazole with clopidogrel are biased and explain the reasons for this suggestion. They summarise, "New recommendations made by the drug agencies are primarily based on little pharmacodynamic data, are not available for all PPIs, and have ...

Haemoglobin decreases in NSAID users over time: an analysis of two large outcome trials

Conclusion‚?? In these two large, independent trials, clinically‚?źmeaningful decreases in haemoglobin ‚?•2‚??g/dL occurred in a relatively similar fashion over time despite differences in trial designs. (Source: Alimentary Pharmacology and Therapeutics)<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>

The potential inhibitory effect of revaprazan, an Acid pump antagonist, on anticoagulation with warfarin.

This study was conducted in order to verify the potential drug interaction between revaprazan and warfarin. Omeprazole, a representative PPI, was used as the control for revaprazan. We searched for patients who were given either revaprazan or omeprazole along with warfarin using the medical record database of Seoul National University Hospital between July 2007 and June 2010. Among the 15 patients who took revaprazan and warfarin together, 73.3% (11/15) showed more than 30% reduction of anticoagulation effect by warfarin after revaprazan was added. The revaprazan group showed a significant shortening of prothrombin time during revaprazan administration compared to pre- and post-revaprazan medication (P &lt; 0.05) while the omeprazole group did not show such difference. Revaprazan seems to ...

OMEPRAZOLE AND SODIUM BICARBONATEcapsule [Par Pharmaceutical Inc.]

Updated Date: Aug 1, 2011 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

Effect of Helicobacter pylori eradication therapy in iron deficiency anaemia of pregnancy - A pilot study.

This study was undertaken to study the effect of eradication therapy in H. pylori infected pregnant women with IDA. Methods: Randomized placebo-controlled double blind clinical trial was done on 40 antenatal women between 14-30 wk gestation, with mild to moderate IDA and having H. pylori infection, as detected by stool antigen test. These women were randomly divided into group I (n=20): H. pylori treatment group (amoxicillin, clarithromycin, omeprazole for 2 wk) and group II (n=20): placebo group. Both groups received therapeutic doses of iron and folic acid. Outcome measures were improvement in haematological parameters and serum iron profile after 6 wk of oral iron therapy. Results: The prevalence of iron deficiency in pregnant women with mild to moderate anaemia was 39.8 per cent (95% C...

Biliary Obstruction From a Bile Duct Mass

Question: A 20-year-old woman with hypertension, bicuspid aortic valve, and gastroesophageal reflux disease was referred for an evaluation due to persistent jaundice, nausea, and vomiting. The patient denied abdominal pain, fevers, chills, diarrhea, constipation, or joint pain. There were no prior surgeries. Medications at the time of presentation included amlodipine, omeprazole, and oral contraceptives. The patient was afebrile on presentation with normal vital signs. The physical examination was notable for jaundice. The abdominal examination was unremarkable; no rashes or lymphadenopathy were present. Laboratory values at presentation were notable for total bilirubin 8.7 mg/dL, direct bilirubin 7.5 mg/dL, alkaline phosphatase 573 U/L, alanine aminotransferase 267 U/L, and aspartate amin...

Room to improve omeprazole prescribing in Oman

(Source: PharmacoEconomics and Outcomes News)<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>

Brief report: Increasing the duration of dual amoxicillin plus omeprazole Helicobacter pylori eradication to 6 weeks: a pilot study

Conclusion: Despite the theory and preexisting data from Japan, in the US prolonging the duration of dual amoxicillin‚?źPPI therapy did not improve treatment outcome to 90% or greater. (Source: Journal of Gastroenterology and Hepatology)

OMEPRAZOLE AND SODIUM BICARBONATEcapsule [Par Pharmaceutical Inc.]

Updated Date: Jul 26, 2011 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

Omeprazole: Acute interstitial nephritis: 2 case reports

(Source: Reactions)

Omeprazole: Hypomagnesaemia: case report

(Source: Reactions)

[Correspondence] Helicobacter pylori eradication

In their randomised, open-label, non-inferiority phase 3 trial, Peter Malfertheiner and colleagues report that quadruple therapy with a capsule containing bismuth subcitrate potassium, metronidazole, and tetracycline given with omeprazole should be considered for first-line treatment of Helicobacter pylori infection. However, one shortcoming weakens the conclusions. (Source: LANCET)<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>

Low levels of adherence with proton pump inhibitor therapy contribute to therapeutic failure in gastroesophageal reflux disease

SUMMARYTo assess adherence to proton pump inhibitor (PPI) treatment and associated variables in patients with gastroesophageal reflux disease (GERD). Cross‚?źsectional and prospective comprising 240 consecutive adult patients, diagnosed with GERD for whom continuous use of standard or double dose of omeprazole had been prescribed. Patients were ranked as ne‚?źGERD (162: 67.5%) or e‚?źGERD classified according to the Los Angeles classification as A (48:20.0%), B (21:8.6%), C (1:0.5%), D (1:0.5%), and Barrett's esophagus (7:2.9%). The Morisky questionnaire was applied to assess adherence to therapy and a GERD questionnaire to assess symptoms and their impact. Adherence was correlated with demographics, cotherapies, comorbidities, treatment duration, symptoms scores, endoscopic findings, and ...

Multicentre trial in people with arthritis finds increased risk of clinically significant gastrointestinal events with diclofenac plus omeprazole compared with celecoxib

Context Although traditional non-steroidal anti-inflammatory drugs (tNSAIDs) have been recognised to have adverse effects throughout the gastrointestinal (GI) tract, emphasis has historically centred on reducing their upper GI ulcerogenic effects.1 Randomised trials and systematic reviews have shown that misoprostol and proton pump inhibitors (PPIs) are effective at reducing the risk of tNSAID-related upper GI toxicity. The tNSAID+PPI strategy emerged as the preferred strategy for several reasons including a favourable side effect profile. Over the last 10 years, the focus has shifted towards using cyclooxygenase-2 (COX-2) inhibitors alone as another effective strategy to reduce upper GI toxicity. COX-2 inhibitors, however, have been associated with other adverse effects, and many have bee...

Effectiveness of the Proton Pump Inhibitor Omeprazole Associated with Calcium Hydroxide as Intracanal Medication: An In Vivo Study

Conclusions: Our data showed that association of omeprazole with Ca(OH)2 favored a superior repair of rat periapical lesions and seemed to display different selective activity over endodontic microbiota, in comparison with the conventional Ca(OH)2 dressing. (Source: Journal of Endodontics)

[Department of Error] Department of Error

Chan FKL, Lanas A, Scheiman J, Berger MF, Nguyen H, Goldstein JL. Celecoxib versus omeprazole and diclofenac in patients with osteoarthritis and rheumatoid arthritis (CONDOR): a randomised trial. Lancet 2010; 376: 173‚??79‚??In this Article (July 17, 2010), the third sentence of the fourth paragraph in the Results section should have read: ‚??The number of patients with moderate-to-severe abdominal symptoms at month 6 was 132 (6%) for the celecoxib group and 162 (7%) for the diclofenac plus omeprazole group (p=0¬∑0495)‚?Ě. (Source: LANCET)

Omeprazole: Gynaecomastia in a neonate: case report

(Source: Reactions)<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>

Comparison of adjuvant therapies by an h2‚?źreceptor antagonist and a proton pump inhibitor after endoscopic treatment in hemostatic management of bleeding gastroduodenal ulcers

Conclusion:‚?? Famotidine and omeprazole injected during the early phase of a bleeding ulcer may have similar effects to an adjuvant therapy for preventing rebleeding from endoscopically treated upper gastrointestinal bleeding in Japanese patients. (Source: Digestive Endoscopy)

Occupational contact allergy to omeprazole and fluoxetine

(Source: Contact Dermatitis)

OMEPRAZOLE (Omeprazole) Capsule, Delayed Release [AvPAK]

Updated Date: Jul 12, 2011 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

GASTROGARD (Omeprazole) Paste [Merial Limited]

Updated Date: Jul 11, 2011 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>

Proton Pump Inhibitors Exacerbate NSAID-Induced Small Intestinal Injury by Inducing Dysbiosis

Conclusions: PPIs exacerbate NSAID-induced intestinal damage at least in part because of significant shifts in enteric microbial populations. Prevention or reversal of this dysbiosis may be a viable option for reducing the incidence and severity of NSAID enteropathy. (Source: Gastroenterology)

PRILOSEC (Omeprazole Magnesium) Capsule, Delayed Release PRILOSEC (Omeprazole Magnesium) Granule, Delayed Release [AstraZeneca LP]

Updated Date: Jul 8, 2011 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

Healing Effects of Rebamipide and Omeprazole in Helicobacter pylori-Positive Gastric Ulcer Patients after Eradication Therapy: A Randomized Double-Blind, Multinational, Multi-Institutional Comparative Study

Digestion 2011;84:221‚??229 (DOI:10.1159/000329353) (Source: Digestion)

ULCERGARD (Omeprazole) Paste [Merial Limited]

Updated Date: Jul 6, 2011 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

[Cardiac invasive aspergillosis in a heart transplant recipient.]

CONCLUSIONS: Invasive aspergillosis affecting the mediastinum can progress and affect the heart tissues. The use of omeprazole may be associated with the undetectable voriconazole serum levels. PMID: 21700234 [PubMed - as supplied by publisher] (Source: Revista Iberoamericana de Micologia)<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>

PRILOSEC OTC (Omeprazole Magnesium) Tablet, Delayed Release [Procter Gamble Manufacturing Company]

Updated Date: Jun 30, 2011 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

Duloxetine/omeprazole interaction: Tako-tsubo cardiomyopathy in an elderly patient: case report

(Source: Reactions)

Race affects healing of erosive oesophagitis in patients treated with proton pump inhibitors

Conclusions‚?? Nonwhite patients with GERD had less severe baseline erosive oesophagitis, but were less likely than white patients to have erosive oesophagitis healing after 8‚?źweek PPI therapy. (Source: Alimentary Pharmacology and Therapeutics)

Nexium IV 40mg Powder for solution for injection/infusion (esomeprazole) - Revised SPC

Source: eMC (electronic Medicines Compendium) Area: Other Library Updates > SPC Changes Section 4.4 of the SPC for Nexium has been updated to include further information regarding potential interactions as a result of CYP2C19 inhibition. Section 4.5 has also been updated to include trial data in relation to the interaction between omeprazole and clopidogrel. See below for link to SPC and full prescribing information. (Source: NeLM - SPC Changes)

Fast HPLC analysis of omeprazole, 5-hydroxyomeprazole and omeprazole sulfone in liquid culture medium using a monolithic column for application in biotransformation studies with fungi

A fast liquid chromatography method was developed and validated for the simultaneous determination of omeprazole (OMZ), 5-hydroxyomeprazole (5-HOMZ) and omeprazole sulphone (OMZ SUL) in liquid culture medium for application in biotransformation studies employing phytopathogenic and endophytic fungi. The separation was achieved using a monolithic Chromolith Fast gradient RP 18 endcapped column, using a mobile phase consisting of 0.15% (v/v) trifluoroacetid acid (TFA) in water (solvent A) and 0.15% (v/v) TFA in acetonitrile (solvent B), under linear gradient of 5 to 90% of B in 1 min, flow rate of 1.0 mL min-1, temperature at 30 ¬ļC and detection at 220 nm. Sample preparation was performed by liquid-liquid extraction, with recoveries in the range of 62.3 to 76.6% for all analytes. The method...<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>

Esomeprazole/omeprazole: Hypomagnesaemia: 10 case reports

(Source: Reactions)

OMEPRAZOLE (Omeprazole) Capsule [Med Health Pharma LLC]

Updated Date: Jun 16, 2011 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

ZEGERID (Omeprazole, Sodium Bicarbonate) Powder, For Suspension ZEGERID (Omeprazole, Sodium Bicarbonate) Capsule [Santarus, Inc.]

Updated Date: Jun 15, 2011 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

Differential ligand-dependent activation and a role for Y322 in aryl hydrocarbon receptor-mediated regulation of gene expression.

In this study, we examined the ability of these compounds to induce AHR-dependent regulation of cytochrome P450 1A1 (CYP1A1) and CYP1B1 in T-47D human breast cancer cells. The role of Y322, a residue implicated in Omp-dependent activation of AHR was also investigated. All four compounds induced CYP1A1 and CYP1B1 mRNA expression, with Omp differing from the HAHs. Chromatin immunoprecipitation assays revealed ligand- and gene-selectivity in the recruitment patterns of AHR coactivators. We also found that residue Y322 of human AHR was important for maximum activation of AHR by 2,3,7,8-TCDD and 2,3,4,7,8-PeCDF, but required for 2,3,7,8-TCDF and Omp in an AHR-deficient MCF-7 human breast cancer cell line. In summary, this study provides evidence for context- and ligand-selective differences in ...

Formulation of multiparticulate systems as lyophilised orally disintegrating tablets.

Authors: Alhusban F, Perrie Y, Mohammed AR The current study aimed to exploit the electrostatic associative interaction between carrageenan and gelatin to optimise a formulation of lyophilised orally disintegrating tablets (ODTs) suitable for multiparticulate delivery. A central composite face centred (CCF) design was applied to study the influence of formulation variables (gelatin, carrageenan and alanine concentrations) on the crucial responses of the formulation (disintegration time, hardness, viscosity and pH). The disintegration time and viscosity were controlled by the associative interaction between gelatin and carrageenan upon hydration which forms a strong complex that increases the viscosity of the stock solution and forms tablet with higher resistant to disintegration in aqu...<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>

Pharmacokinetics of two formulations of omeprazole administered through a gastrostomy tube in patients with severe neurodevelopmental problems

Conclusions: In this population, omeprazole MUPS¬ģ formulation has no apparent advantage over the more easily administered suspension formulation. (Source: British Journal of Clinical Pharmacology)

Pharmacokinetics of the HIV integrase inhibitor S/GSK1349572 co-administered with acid-reducing agents and multivitamins in healthy volunteers

Conclusions S/GSK1349572 can be taken with proton pump inhibitors and MVIs without dose adjustment but should be administered 2 h before or 6 h after antacids. (Source: Journal of Antimicrobial Chemotherapy)

OMEPRAZOLE/SODIUM BICARBONATE (Omeprazole, Sodium Bicarbonate) Powder, For Suspension OMEPRAZOLE/SODIUM BICARBONATE (Omeprazole, Sodium Bicarbonate) Capsule [Prasco, Laboratories]

Updated Date: Jun 6, 2011 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

PRILOSEC (Omeprazole Magnesium) Capsule, Delayed Release PRILOSEC (Omeprazole Magnesium) Granule, Delayed Release [AstraZeneca LP]

Updated Date: Jun 6, 2011 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

Identification and quantification of glutathione adducts of clozapine using ultra-high-performance liquid chromatography with orthogonal acceleration time-of-flight mass spectrometry and inductively coupled plasma mass spectrometry.

Authors: Macdonald C, Smith C, Michopoulos F, Weaver R, Wilson ID The application of sulphur-specific detection via ultra-performance liquid chromatography coupled to inductively coupled plasma mass spectrometry (UPLC/ICPMS) to detect and quantify the glutathione (GSH)-adducts produced via the in vitro formation of reactive metabolites is demonstrated. The adducts were formed in human liver microsomes supplemented with unlabelled GSH for clozapine. The calculation of adduct concentration was performed via comparison of the peak areas to calibration curves constructed from omeprazole, a sulphur-containing compound over the range of 0.156 to 15.62‚??őľM of sulphur with a detection limit of 1.02‚??ng of sulphur on-column. Identification of the adducts was performed using conventional UPLC...<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>

Eosinophilic esophagitis in patients with typical gastroesophageal reflux disease symptoms refractory to proton pump inhibitor

CONCLUSION: Our results demonstrated a low prevalence of EoE among patients with refractory GERD undergoing omeprazole treatment. (Source: Clinics)

GI Highlights from the literature

Further poly- to the pills for Helicobacter pylori eradication? &nbsp;Malfertheiner P, Bazzoli F, Delchier JC, et al. H pylori eradication with a capsule containing bismuth subcitrate potassium, metronidazole, and tetracycline given with omeprazole versus clarithromycin-based triple therapy: a randomised, open-label, non-inferiority, phase 3 trial. Lancet 2011;377:905&ndash;13. H pylori is the main cause of peptic ulcer and gastric cancer worldwide. Eradication of the bacterium is therefore advocated in most patients found to be infected with it. Proton pump inhibitor-based triple therapy is the accepted first-line therapy, but their have been concerns about reduced efficacy in recent years. Bismuth-based quadruple therapy is reserved as second-line therapy, due to concerns regarding toler...

Clozapine/omeprazole interaction: Increased plasma clozapine concentrations and neutropenia?: case report

(Source: Reactions)

Metabolism of thalidomide by human liver microsome cytochrome CYP2C19 is required for its antimyeloma and antiangiogenic activities in vitro

In this study, we used a system of human liver microsomes to investigate the antimyeloma and antiangiogenic activities of thalidomide. Myeloma cells and human umbilical vein endothelial cells (HUVECs) were treated with thalidomide alone or thalidomide incubated with human liver microsomal protein. We found that thalidomide alone had no direct effect on several multiple myeloma cell lines (U266, NCI‚?źH929, RPMI 8226, LP‚?ź1, CZ‚?ź1) or on HUVECs in vitro. However, when incubated with human liver microsomal protein, thalidomide (100‚??¬Ķg/ml) caused a decrease of 34.9‚??46.7% in cell viability in myeloma cells and 12% in HUVECs. Cell cycle analysis and apoptosis detection indicated that the decreases in cell viability were correlated with the induction of apoptosis. Thalidomide incubated wi...

Efficacy of Levofloxacin and Rifaximin based Quadruple Therapy in Helicobacter pylori Associated Gastroduodenal Disease: A Double-Blind, Randomized Controlled Trial.

In conclusion, the levofloxacin and rifaximin based regimen comes up to the standard triple therapy, but has a limited efficacy in a Korean cohort. The rifaximin containing regimen has a very high safety profile for H. pylori eradication therapy. PMID: 21655065 [PubMed - in process] (Source: J Korean Med Sci)<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>

ZEGERID (Omeprazole, Sodium Bicarbonate) Powder, For Suspension ZEGERID (Omeprazole, Sodium Bicarbonate) Capsule [Santarus, Inc.]

Updated Date: May 31, 2011 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

Omeprazole Babies and Toddlers Drug Information - Prilosec and Infants

Omeprazole Babies and Toddlers Information - proton pump inhibitors and infants - what you need to know about Prilosec and Losec for infants and toddlers (Source: Blog from a Pediatrician)

Development and validation of a highly sensitive LC-MS/MS method for quantitation of dexlansoprazole in human plasma: application to a human pharmacokinetic study.

Authors: Hotha KK, Vijaya Bharathi D, Jagadeesh B, Ravindranath LK, Jaya Veera KN, Venkateswarulu V A highly sensitive, specific and simple LC-MS/MS method was developed for the simultaneous estimation of dexlansoprazole (DEX) with 50‚??őľL of human plasma using omeprazole as an internal standard (IS). The API-4000 LC-MS/MS was operated under multiple reaction-monitoring mode using electrospray ionization. A simple liquid-liquid extraction process was used to extract DEX and IS from human plasma. The total run time was 2.00‚??min and the elution of DEX and IS occurred at 1.20‚??min. This was achieved with a mobile phase consisting of 0.2% ammonia-acetonitrile (20:80, v/v) at a flow rate of 0.50‚??mL/min on an X-terra RP 18 (50‚??√?‚??4.6‚??mm, 5‚??¬Ķm) column. The developed method was ...

An Unexpected Cause of Emesis

A 23-month-old boy presented to a tertiary care Emergency Department with a 2-day history of non-bilious, non-bloody emesis and fever. The child had global developmental delay, obstructive sleep apnea, sensorineural hearing loss, vesicoureteric reflux, and gastroesophageal reflux requiring gastrojejunal (GJ) feeding. He had a mild cough with no rhinitis and no history of diarrhea. There was no history of sick contacts or recent travel. Medications included domperidone, omeprazole, and co-trimoxazole for urinary tract infection prophylaxis. (Source: The Journal of Emergency Medicine)

Study: Pills, surgery both effective for chronic reflux

Both surgery and popular medications such as Nexium, Prevacid or Prilosec can successfully treat the discomfort of chronic reflux, according ... (Source: USATODAY.com Health)<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>

High Eradication Rates of Helicobacter pylori Infection Following Sequential Therapy: The Israeli Experience Treating Na√Įve Patients

Conclusion:‚?? The sequential regimen attained significantly higher eradication rates in na√Įve patients than usually reported for conventional triple therapy. Sequential therapy may be an alternative first‚?źline therapy in eradicating H.¬†pylori in Israel. (Source: Helicobacter)

Omeprazole: Nausea in an elderly patient: case report

(Source: Reactions)

Omeprazole: Subacute cutaneous lupus erythematosus in elderly patients: 2 case reports

(Source: Reactions)

Efficacy of Lactobacillus casei treatment on small bowel injury in chronic low-dose aspirin users: a pilot randomized controlled study

Conclusions&nbsp;&nbsp;Co-administration of L. casei is effective for the treatment of aspirin-associated small bowel injury. Content Type Journal ArticlePages 1-12DOI 10.1007/s00535-011-0410-1Authors Hiroki Endo, Division of Gastroenterology, Yokohama City University School of Medicine, 3-9 Fukuura, Kanazawa-ku, Yokohama, 236-0004 JapanTakuma Higurashi, Department of Gastroenterology, Yokohama Rosai Hospital, 3211 Kozukue, Kohoku-ku, Yokohama, JapanKunihiro Hosono, Division of Gastroenterology, Yokohama City University School of Medicine, 3-9 Fukuura, Kanazawa-ku, Yokohama, 236-0004 JapanEiji Sakai, Division of Gastroenterology, Yokohama City University School of Medicine, 3-9 Fukuura, Kanazawa-ku, Yokohama, 236-0004 JapanYusuke Sekino, Division of Gastroenterology, Yokohama Ci...

Study: Stomach Acid Drugs Linked to Fracture Risk

Long-term, regular users of a proton pump inhibitor (PPI) such as Nexium, Prevacid, Prilosec, and Protonix appear to have a heightened risk of fractures, a study shows. (Source: WebMD Health)<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>

Popular Heartburn Meds May Boost Fracture Risk

Study sees possible link to proton pump inhibitors such as Prilosec, Prevacid and Nexium (Source: Pharmacy News - Doctors Lounge)

Study: Stomach Acid Drugs Linked to Fracture Risk

Long-term, regular users of a proton pump inhibitor (PPI) such as Nexium, Prevacid, Prilosec, and Protonix appear to have a heightened risk of fractures, a study shows. (Source: WebMD Health)

Internal standard tracked dilution to overcome challenges in dried blood spots and robotic sample preparation for liquid chromatography/tandem mass spectrometry assays.

Authors: Liu G, Snapp HM, Ji QC Dried blood spot (DBS) technology is an emerging alternative for sample collection in bioanalysis. Dilution for DBS samples is a challenge due to its solid sample format. Currently, DBS samples requiring dilution were first extracted as regular samples and then diluted with extracted blank samples containing internal standard (IS). Since the dilution step is a volume-critical step, extra care has to be taken to achieve accurate dilution when dealing with limited volume extracted samples. Here, we introduce an alternative sample dilution for liquid chromatography/tandem mass spectrometry (LC/MS/MS) assays using IS to track the dilution step. Dilution factor-adjusted IS working solution was first added to the sample requiring dilution before sample process...

Gastric Ulcerogenic and Healing Impairment Actions of Alendronate, A Nitrogen-Containing Bisphosphonate - Prophylactic Effects of Rebamipide.

Authors: Takeuchi K, Kato S, Amagase K Alendronate, a nitrogen containing bisphosphonate (BP), when given p.o., decreased the transmucosal potential difference by direct irritating action, resulting in non-hemorrhagic lesions in both the corpus and antrum of fasted rats. After refeeding for 3 days the lesions in the corpus healed, while those in the antrum developed into large ulcers with increased vascular permeability; the damaged mucosa was covered with a white cap, mainly composed of fibrin-like substances and exfoliated cells. These ulcers were accompanied by an increase in MPO activity and lipid peroxidation as well as a decrease in SOD activity and GSH content in the mucosa. Neither omeprazole nor indomethacin had any effect, while allopurinol and SOD reduced the severity of the...<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>

Identification and Characterization of the Acid Phosphatase HppA in Helicobacter pylori.

Authors: Ki MR, Yun SK, Choi KM, Hwang SY An acid phosphatase (HppA) activated by NH4Cl was purified 192- and 34-fold from the periplasmic and membrane fractions of Helicobacter pylori, respectively. SDS-polyacrylamide gel electrophoresis revealed that HppA from the latter appears to be several kilodaltons larger in molecular mass than from the former by about 24 kDa. Under acidic conditions (pH&lt; or =4.5), the enzyme activity was entirely dependent on the presence of certain mono- and/or divalent metal cations (e.g., K+, NH4 +, and/or Ni2+). In particular, Ni2+ appeared to lower the enzyme's Km for the substrates, without changing Vmax. The purified enzyme showed differential specificity against nucleotide substrates with pH; for example, the enzyme hydrolyzed adenosine nucleotides ...

Clopidogrel and Proton Pump Inhibitors: Influence of Pharmacological Interactions on Clinical Outcomes and Mechanistic Explanations

Dual antiplatelet therapy with aspirin and clopidogrel is associated with a significant reduction in vascular ischemic events; however, gastrointestinal bleeding events are a major concern in high-risk and older patients. Clinical practice guidelines recommend combination therapy with proton pump inhibitors (PPI) and dual antiplatelet therapy to attenuate gastrointestinal bleeding risk. In addition, high on-treatment platelet reactivity has been associated with recurrent ischemic events. Whether or not the pharmacological interaction between clopidogrel and PPI, which results in diminished antiplatelet effect, adversely influences clinical efficacy is highly controversial and the subject of debate. Based on largely anecdotal post-hoc analyses, the U.S. Federal Drug Administration's and Eur...

Pharmacokinetics and antitumor activity of patupilone combined with midazolam or omeprazole in patients with advanced cancer

Conclusions&nbsp;&nbsp;Patupilone was not a potent CYP3A4 or CYP2C19 inhibitor. No dose adjustment is required when omeprazole or midazolam is used in patients treated with patupilone. Patupilone exhibited promising antitumor activity in heavily pretreated patients with ovarian and pancreatic cancer. Content Type Journal ArticlePages 1-10DOI 10.1007/s00280-011-1635-7Authors Apostolia-Maria Tsimberidou, Phase 1 Program, Department of Investigational Cancer Therapeutics, The University of Texas MD Anderson Cancer Center, 1515 Holcombe Boulevard, Unit 455, Houston, TX 77030, USANancy Lewis, Fox Chase Cancer Center, Philadelphia, PA, USATony Reid, Moores Cancer Center, University of California San Diego, San Diego, CA, USAHoward Burris, Sarah Cannon Cancer Center, Nashville, TN, U...

In vitro Studies Investigating the Interactions between Degarelix, a Decapeptide GnRH Blocker, and Cytochrome P450

In this study, the interaction of degarelix with human cytochrome P450 (CYP450) enzymes was investigated in vitro. Inhibition of CYP450 was performed in human liver microsomes using documented marker substrates for the CYP450 isozymes CYP1A2, CYP2B6, CYP2C8, CYP2C9, CYP2C19, CYP2D6, CYP3A4 and CYP2E1. The inhibitory effects on selected P450 enzyme activities were investigated with degarelix concentrations representing the range of 2‚?ź200 times of expected clinical concentrations. No inhibition of any isozyme‚?źcatalysed biotransformations studied was detected.Induction of CYP450 enzyme activity by degarelix was investigated using primary human hepatocytes. Cryo‚?źpreserved plateable hepatocytes and fresh hepatocytes in culture were treated for two ‚?ź three consecutive days with degarelix...

In Vitro Studies Investigating the Interactions between Degarelix, a Decapeptide Gonadotropin‚?źReleasing Hormone Blocker, and Cytochrome P450

In this study, the interaction of degarelix with human cytochrome P450 (CYP450) enzymes was investigated in vitro. Inhibition of CYP450 was performed in human liver microsomes using documented marker substrates for the CYP450 isozymes CYP1A2, CYP2B6, CYP2C8, CYP2C9, CYP2C19, CYP2D6, CYP3A4 and CYP2E1. The inhibitory effects on selected P450 enzyme activities were investigated with degarelix concentrations representing the range of 2‚??200 times of expected clinical concentrations. No inhibition of any isozyme‚?źcatalysed biotransformations studied was detected. Induction of CYP450 enzyme activity by degarelix was investigated using primary human hepatocytes. Cryopreserved plateable hepatocytes and fresh hepatocytes in culture were treated for two‚?źthree consecutive days with degarelix at ...<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>

Effects of different proton pump inhibitors on cardiac contractility in isolated human failing myocardium.

CONCLUSION: We conclude that proton pump inhibitors show significant negative inotropic effects on isolated human failing myocardium. There is no apparent difference seen in the magnitude of the effects of each PPI-group. Further, in-vivo investigations are necessary to reveal the clinical evidence of PPI's negative inotropic effects, e.g. in cardio-surgical patients with heart failure. PMID: 21499223 [PubMed - as supplied by publisher] (Source: The Journal of Cardiovascular Surgery)

Influence of esomeprazole on hypoglycemic activity of oral antidiabetic agents in rats and rabbits.

Authors: Phadatare PD, Chandrashekhar VM Gastrointestinal symptoms are fairly common in diabetes mellitus. Glimepride, is a latest second generation sulfonylurea used for the treatment of type II diabetes mellitus, is a insulin secrectagogue; indirectly, it also increases insulin secretion and its specific effect on pancreatic ATP-dependent K(+) channel inhibition. Esomeprazole, the (S)-isomer of omeprazole, is the first proton pump inhibitors developed as a single isomer for the treatment of acid-peptic diseases by specific inhibition of H(+)/K(+)-ATPase in gastric parietal cell. Since there is possibility for drug interaction leading to decreased activity of glimepride, the present study was conducted to evaluate the effect of the combination. Studies in normal and alloxan induced di...

Are Proton Pump Inhibitors Effective in the Treatment of GERD in Children?

In a new study, researchers reviewed 12 clinical trials that studied the effectiveness of medications for treating gastroesophageal reflux disease in infants, children, and teens. The researchers found there was wasn't enough evidence to show that these medications, proton pump inhibitors (PPIs), were that effective in treating symptoms of GERD in infants. For older children and teens, these medication appeared to be more effective in treating the symptoms. This researchers, in an article published in the journal, Pediatrics, stated that there isn't enough data yet to tell whether or not there is any long-term benefits or safety to using PPIs in children. However, this doesn't mean PPIs should never be used to treat GERD in children, according to lead researcher Dr. Rachel J. van der Po...

Symmetrical drug‚?źrelated intertriginous and flexural exanthema (Baboon syndrome) induced by omeprazole

(Source: International Journal of Dermatology)

Study questions heartburn drugs for kids

NEW YORK (Reuters Health) - Acid-suppressing drugs like Prilosec and Prevacid may not be much help for infants with troublesome acid reflux, and there's too little evidence that they help older children and teenagers, a new research review concludes. (Source: Reuters: Health)

Study Questions Heartburn Drugs for Kids

Acid-suppressing drugs like Prilosec and Prevacid may not be much help for infants with troublesome acid reflux, and there's too little evidence that they help older children and teenagers, a new research review concludes.Source: Reuters Health Related MedlinePlus Pages: Children's Health, GERD (Source: MedlinePlus Health News)

The Comparative Study of the Effectiveness of Cimetidine, Ranitidine, Famotidine, and Omeprazole in Treatment of Children with Dyspepsia

Conclusion. If a cure is defined as all symptoms relief after a period of 4 weeks treatment, our findings showed that Omeperazole are superior to Ranitidine, Famotidine, and Cimetidine for management of functional dyspepsia. (Source: Journal of Oncology)

Proton pump inhibitors for the prevention of stress-related mucosal disease in critically-ill patients: a meta-analysis

Source: DARE Area: Evidence > Disease Focused Reviews CRD Summary: The review found a significantly lower rate of clinically important bleeding when using proton pump inhibitors rather than histamine-2 receptor antagonists in the prevention of stress-related mucosal disease in critically ill patients. Rates of nosocomial pneumonia were similar. The reliability of the authors' conclusions is unclear due to some methodological weaknesses and differences between the small number of studies. [Included studies were of omeprazole compared with ranitidine, famotidine or cimetidine.] CRD Commentary: The review addressed a well-defined question in terms of participants, interventions, study design and relevant outcomes. Relevant databases were searched, but it appeared that unpublished studies...

Long-term proton pump inhibitor administration worsens atrophic corpus gastritis and promotes adenocarcinoma development in Mongolian gerbils infected with Helicobacter pylori

Conclusion Long-term PPI administration promotes development of adenocarcinoma, which is associated with the progression of atrophic corpus gastritis in MGs infected with H pylori. (Source: Gut)<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>

Assessment of a novel ő≤(2)-adrenoceptor agonist, trantinterol, for interference with human liver cytochrome P450 enzymes activities.

Authors: Jiang K, Li K, Qin F, Lu X, Li F The effect of a novel ő≤(2)-adrenoceptor agonist, trantinterol on the activities of cytochrome P450 (CYP450) was investigated with human liver microsomes and human cryohepatocytes in order to assess the potential for drug-drug interactions. The ability of trantinterol to inhibit CYP450 activities was evaluated in vitro in human liver microsomes. Trantinterol did not inhibit CYP2C19, CYP2D6, and CYP3A4/5 (IC(50)&gt;100őľM). It acted as a weak inhibitor of CYP1A2 and CYP2C9 with IC(50) of 70.8 and 81.9őľM, respectively. No time-dependent inhibitions were observed in the present research. To evaluate CYP450 induction, human cryohepatocytes (n=3) were used and treated once daily for 3days with trantinterol (0.01, 0.1, and 1ng/ml), after which CYP45...

Omeprazole decreases magnesium transport across Caco-2 monolayers.

Authors: Thongon N, Krishnamra N To elucidate the effect and underlying mechanisms of omeprazole action on Mg(2+) transport across the intestinal epithelium. PMID: 21472124 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)

POZEN Reports Superior Platelet Inhibition Of PA32540 Regimen Over A Standard Of Care Regimen In A Phase 1 Study ("Co-Rx")

POZEN Inc. (NASDAQ: POZN), a pharmaceutical company committed to transforming medicine that transforms lives, announced today positive top-line results of a Phase 1 study of PA32540, a novel coordinated-delivery tablet of enteric-coated (EC) aspirin (325 mg) and immediate-release (IR) omeprazole (40 mg)... (Source: Health News from Medical News Today)

Proton Pump Inhibitors (PPI): Class Labeling Change

including Nexium, Dexilant, Prilosec, Zegerid, Prevacid, Protonix, Aciphex, Vimovo, Prilosec OTC, Zegerid OTC, and Prevacid 24HR [UPDATED 3/22/2011] FDA has determined an osteoporosis and fracture warning on the over-the-counter (OTC) proton... (Source: Drugs.com - Pharma News)

FDA Clears Heartburn Drugs

The Food and Drug Administration said over-the-counter stomach-acid-reducing drugs such as Prevacid and Prilosec don't appear to be associated with an increased fracture risk and scrapped plans to update the drug labels to warn of such risk. (Source: WSJ.com: Health)<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>

FDA Clears OTC Heartburn Drugs

The Food and Drug Administration said over-the-counter stomach-acid-reducing drugs such as Prevacid and Prilosec don't appear to be associated with an increased fracture risk and scrapped plans to update the drug labels to warn of such risk. (Source: WSJ.com: Health)

Proton pump inhibitors and the risk of overanticoagulation during acenocoumarol maintenance treatment

SummaryIn the Netherlands, several reports have described a potentiation of acenocoumarol‚?źinduced anticoagulation by co‚?źmedication of omeprazole or esomeprazole and competitive inhibition of CYP2C19 has been suggested as a possible mechanism for this interaction. We conducted an observational cohort study to investigate the effects of various proton pump inhibitors (PPIs) on acenocoumarol effectiveness. All 2755 subjects from the Rotterdam Study who received acenocoumarol maintenance treatment between April 1st, 1991 and September 9th, 2009 were followed for events of an international normalized ratio (INR)‚??‚?•‚??6, until death, end of treatment, or end of the study period. The Andersen‚??Gill extension of the Cox proportional hazards model was used to calculate risks for repeated ev...

Proton-pump-inhibitors for treatment of reflux in a breastfeeding mother: which is preferred?

Source: Trent Medicines Information Service Area: Evidence > Medicines Q & A There is limited experience with the use of omeprazole and pantoprazole during lactation. &nbsp; Milk levels for both drugs are low, and in addition a large proportion of any of the drug ingested by the infant is likely to be destroyed by the acid in the stomach. &nbsp; No adverse events were reported in one case report of an infant exposed to omeprazole via breast milk. &nbsp; There are no data on long-term outcome. There are no data available regarding use of lansoprazole, rabeprazole or esomeprazole during breastfeeding. If a PPI is regarded necessary during lactation, limited data support the use of omeprazole or pantoprazole, and an influence on a breastfed child's development is unli...

Choledochal cyst: A review of 79 cases and the role of hepaticodochoduodenostomy

Conclusions : In choledochal cyst, complete excision of cyst and good bilioenteric anastomosis with wide stoma should be done. Hepaticodochoduodenostomy with wide stoma is a simple, quick procedure with preservation of normal anatomy and physiology and minimum complications. It also avoids multiple intestinal anastomoses and so should be the preferred approach. (Source: Journal of Indian Association of Pediatric Surgeons)

Influence of Different Proton Pump Inhibitors on Activity of Cytochrome P450 Assessed by [13C]-Aminopyrine Breath Test.

Authors: Kodaira C, Uchida S, Yamade M, Nishino M, Ikuma M, Namiki N, Sugimoto M, Watanabe H, Hishida A, Furuta T Aminopyrine is metabolized by cytochrome P450 (CYP) in the liver. The investigators evaluated influences of different PPIs on CYP activity as assessed by the [(13)C]-aminopyrine breath test ([(13)C]-ABT). Subjects were 15 healthy volunteers with different CYP2C19 status (5 rapid metabolizers [RMs], 5 intermediate metabolizers [IMs], and 5 poor metabolizers [PMs]). Breath samples were collected before and every 15 to 30 minutes for 3 hours after oral ingestion of [(13)C]-aminopyrine 100 mg on day 8 of each of the following regimens: control; omeprazole 20 mg and 80 mg, lansoprazole 30 mg, and rabeprazole 20 mg. Changes in carbon isotope ratios in carbon dioxide ((13)CO(2)/(1...<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>

Clopidogrel‚??Drug Interactions

Multidrug therapy increases the risk for drug‚??drug interactions. Clopidogrel, a prodrug, requires hepatic cytochrome P450 (CYP) metabolic activation to produce the active metabolite that inhibits the platelet P2Y12 adenosine diphosphate (ADP) receptor, decreasing platelet activation and aggregation processes. Atorvastatin, omeprazole, and several other drugs have been shown in pharmacodynamic studies to competitively inhibit CYP activation of clopidogrel, reducing clopidogrel responsiveness. Conversely, other agents increase clopidogrel responsiveness by inducing CYP activity. The clinical implications of these pharmacodynamic interactions have raised concern because many of these drugs are coadministered to patients with coronary artery disease. There are multiple challenges in proving ...

Adding omeprazole to clopidogrel reduced GI events and did not increase CV events.

Authors: PMID: 21403070 [PubMed - in process] (Source: Annals of Internal Medicine)

[Articles] Helicobacter pylori eradication with a capsule containing bismuth subcitrate potassium, metronidazole, and tetracycline given with omeprazole versus clarithromycin-based triple therapy: a randomised, open-label, non-inferiority, phase 3 trial

Quadruple therapy should be considered for first-line treatment in view of the rising prevalence of clarithromycin-resistant H pylori, especially since quadruple therapy provides superior eradication with similar safety and tolerability to standard therapy. (Source: LANCET)

Financial evaluation of unlicensed medication supplied on FP10HP at UHNS

Conclusion There are clear financial benefits from dispensing these unlicensed medications at UHNS pharmacy compared with supply on FP10HP, with potential annual savings of approximately &pound;26 000. DrugNet cost FP10HPNet cost UHNSPotential savingMelatonin 3 mg SR capsules&pound;2627.63&pound;291.6&pound;2336.02Melatonin 3 mg capsules&pound;8488.69&pound;535.6&pound;7953.09Biomelatonin 3 mg cap&pound;3571.52&pound;241.3&pound;3330.02Melatonin 5 mg/5 ml&pound;11010.48&pound;1967.71&pound;9042.77Melatonin other preparations&pound;1117.34&pound;374.76&pound;742.58Omeprazole 10 mg/5 ml&pound;3089.16&pound;173.94&pound;2915.22Total saving&pound;26319.7 In addition, hospital supply allows the pharmacy team to check unlicensed medications are only supplied when they are the only clinically a...

Sequential therapy vs. standard triple therapy for Helicobacter Pylori Eradication in children: RCT

Source: Journal of Pediatrics Area: News Triple therapy remains the recommended first line treatment for Helicobacter pylori infection. However, increased resistance to antibiotics used in the triple therapy is of concern, and this there has been interest in novel therapeutic strategies, one of which is sequential therapy-two-step, 10-day therapy consisting of administration of a proton pump inhibitor with amoxicillin for the first 5 days, followed by triple therapy that includes a proton pump inhibitor, clarithromycin, and tinidazole for another 5 days. Data on this regimen are limited. This RCT evaluated the effectiveness of sequential therapy compared with standard triple therapy for Helicobacter pylori eradication in children. &nbsp; The study involved 107 children randomised to r...<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>

Potential drug interactions in patients with rheumatoid arthritis

CONCLUSION: Considering that this study confirms that polypharmacy is a common therapeutic practice in RA patients, it is worth emphasizing the need for greater surveillance regarding the adverse effects or effectiveness reduction of certain drugs due to drug interaction (Source: Revista Brasileira de Reumatologia)

Melatonin and steroid hormones activate intermembrane Cu,Zn-superoxide dismutase by means of mitochondrial cytochrome P450.

This study was aimed at investigating the potential association between the hormonal protective antioxidant actions in mitochondria and regulation of IMS SOD1 activity. Melatonin, testosterone, dihydrotestosterone, estradiol, and vitamin D induced a sustained activation over time of SOD1 in intact mitochondria showing a bell-shaped enzyme activation dose-response with a threshold at 50 nM and a maximum effect at 1őľM concentration. Enzyme activation was not affected by furafylline, but it was inhibited by omeprazole, ketoconazole, and tiron, thereby supporting the occurrence of a mitochondrial P450 activity and O(2)(.-) requirements. Mitochondrial P450-dependent activation of IMS SOD1 prevented O2.- -induced loss of aconitase activity in intact mitochondria respiring at state 3 respiration...

Omeprazole: Anaphylaxis: case report

(Source: Reactions)

Impact of proton pump inhibitors on efficacy of clopidogrel: Review of evidence

Suresh D Mistry, Hiren R Trivedi, Dinesh M Parmar, Prashant S Dalvi, Chacko JiyoIndian Journal of Pharmacology 2011 43(2):183-186Clopidogrel is a prodrug which requires cytochrome P450 2C19 (CYP 2C19) enzyme for its conversion to an active thiol metabolite. Proton pump inhibitors (PPIs) inhibits enzyme CYP 2C19 interfering with the conversion of clopidogrel into its active metabolite. Studies document the possible interaction of clopidogrel and PPIs leading to a decrease in the antiplatelet efficacy of clopidogrel. A PubMed/MEDLINE database literature search was carried out and the bibliographies of found articles were checked for other relevant literature. Most retrospective cohort studies and studies using platelet markers found a significant association between PPI use especially omepra...

Sequential Therapy Compared with Standard Triple Therapy for Helicobacter Pylori Eradication in Children: A Double-Blind, Randomized, Controlled Trial

Conclusions: In children with H pylori infection, sequential eradication therapy compared with standard triple therapy resulted in a higher eradication rate, although the difference was of borderline statistical significance. (Source: The Journal of Pediatrics)<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>

Proton Pump Inhibitor drugs (PPIs): Drug Safety Communication - Low Magnesium Levels Can Be Associated With Long-Term Use

Audience: Consumer, Gastroenterology, Family Practice Prescription PPIs include Nexium (esomeprazole magnesium), Dexilant (dexlansoprazole), Prilosec (omeprazole), Zegerid (omeprazole and sodium bicarbonate), Prevacid (lansoprazole), Protonix... (Source: Drugs.com - FDA MedWatch Alerts)

Low Magnesium Levels Associated With Long-Term Proton Pump Inhibitor Use

The FDA notified healthcare providers that proton pump inhibitors (PPIs) may cause low serum magnesium levels (hypomagnesemia) if taken for prolonged periods of time (usually longer than one year). Low serum magnesium levels can result in serious adverse events including muscle spasm (tetany), irregular heartbeat (arrhythmias), and convulsions (seizures), though not all patients have these symptoms. Treatment of hypomagnesemia generally requires magnesium supplements. In approximately one-quarter of the cases reviewed, magnesium supplementation alone did not improve low serum magnesium levels and the PPI had to be discontinued. The FDA is encouraging healthcare providers to obtain serum magnesium levels before starting PPI treatment in those patients they expect to be on these drugs for l...

Role of Omeprazole Dosage and Cytochrome P450 2C19 Genotype in Patients Receiving Omeprazole-Amoxicillin Dual Therapy for Helicobacter pylori Eradication

Conclusion. Provided a maintenance dose of amoxicillin is given every 6 hours, eradication of H. pylori infection was significantly dependent on omeprazole dosage, CYP2C19 genotype, age, gastritis status, and H. pylori density. (Source: Pharmacotherapy: Official Journal of the American College of Clinical Pharmacy)

Melatonin or l‚?źtryptophan accelerates healing of gastroduodenal ulcers in patients treated with omeprazole

Abstract:‚?? Melatonin and l‚?źtryptophan (Trp) are highly gastroprotective in humans, but no study has assessed their impact on healing of chronic gastroduodenal ulcers in humans. Three groups (A, B and C) of 14 idiopathic patients in each treatment group with gastroduodenal chronic ulcers were treated with omeprazole (20‚??mg twice daily) combined either with placebo (group A), melatonin (group B) or with Trp (group C). The rate of ulcer healing was determined by gastroduodenoscopy at day 0, 7, 14 and 21 after initiation of therapy. Plasma melatonin, gastrin, ghrelin and leptin were measured by RIA. On day 7, omeprazole by itself (group A) had not healed any ulcers, but four ulcers were healed with omeprazole plus melatonin and two with omeprazole plus tryptophan. At day 21, all ulcers w...

Clinical usefulness of limited sampling strategies for estimating AUC of proton pump inhibitors.

This article reviewed the usefulness of LSS for estimating AUC of three PPIs (omeprazole: OPZ, lansoprazole: LPZ and rabeprazole: RPZ). The best prediction formulas in each PPI were AUC(OPZ)=9.24 x C(6h)+2638.03, AUC(LPZ)=12.32 x C(6h)+3276.09 and AUC(RPZ)=1.39 x C(3h)+7.17 x C(6h)+344.14, respectively. In order to optimize the sampling strategy of LPZ, we tried to establish LSS for LPZ using a time point within 3 hours through the property of pharmacokinetics of its enantiomers. The best prediction formula using the fewest sampling points (one point) was AUC(racemic LPZ)=6.5 x C(3h) of (R)-LPZ+13.7 x C(3h) of (S)-LPZ-9917.3 x G1-14387.2√?G2+7103.6 (G1: homozygous extensive metabolizer is 1 and the other genotypes are 0; G2: heterozygous extensive metabolizer is 1 and the other genotypes a...<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>

Effects of Intravenously Administered Esomeprazole Sodium on Gastric Juice pH in Adult Female Horses

Conclusions and Clinical Importance: Esomeprazole sodium shows promise for treatment of gastric ulcers in horses with signs of dysphagia, gastric reflux, or other conditions that restrict oral intake of the current Federal Drug Administration‚?źapproved omeprazole paste. (Source: Journal of Veterinary Internal Medicine)

Epigallocatechin gallate accelerates healing of indomethacin-induced stomach ulcers in mice.

Authors: Adhikary B, Yadav SK, Bandyopadhyay SK, Chattopadhyay S Management of the gastric toxicity of non-steroidal anti-inflammatory drugs (NSAIDs) remains a crucial problem because the commercially available drugs have side effects and are often expensive. Therefore, we examined the potential of the green tea-derived polyphenol epigallocatechin gallate (EGCG) to treat indomethacin-induced stomach ulcers in mice. Administration of indomethacin (18 mg/kg, po) to mice induced ulceration in the glandular portion of the gastric mucosa, accompanied by increased lipid peroxidation (LPO) and protein oxidation and reductions in thiol defense, mucin, cyclooxygenase (COX) expression and prostaglandin (PG) synthesis in the gastric tissues. Daily oral administration of EGCG (2 mg/kg) or omeprazo...

Metabolism of thalidomide by human liver microsome cytochrome CYP2C19 is required for its antimyeloma and antiangiogenic activities in vitro

In this study, we used a system of human liver microsomes to investigate the antimyeloma and antiangiogenic activities of thalidomide. Myeloma cells and human umbilical vein endothelial cells (HUVECs) were treated with thalidomide alone or thalidomide incubated with human liver microsomal protein. We found that thalidomide alone had no direct effect on several multiple myeloma cell lines (U266, NCI‚?źH929, RPMI 8226, LP‚?ź1, CZ‚?ź1) or on HUVECs in vitro. However, when incubated with human liver microsomal protein, thalidomide (100‚??¬Ķg/ml) caused a decrease of 34.9‚??46.7% in cell viability in myeloma cells and 12% in HUVECs. Cell cycle analysis and apoptosis detection indicated that the decreases in cell viability were correlated with the induction of apoptosis. Thalidomide incubated wi...

H pylori therapy better than gold standard

Quadruple therapy with a proton-pump inhibitor plus a single three-in-one capsule is better than the gold-standard treatment regimen of omeprazole, amoxicillin, and clarithromycin in adults with Helicobacter pylori infection, a new trial... (Source: Pulse)

Effects of omeprazole on symptoms and quality of life in Japanese patients with reflux esophagitis: Final results of OMAREE, a large-scale clinical experience investigation

Conclusion: In a large-scale survey, omeprazole improved symptoms and QOL more effectively in Japanese patients with RE than other investigated drugs, and had a good tolerability profile. (Source: BMC Gastroenterology)<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>

Proton pump inhibitors reduce interferon‚?źő≥‚?źinduced neurotoxicity and STAT3 phosphorylation of human astrocytes

AbstractProton pump inhibitors (PPIs) are known to possess anti‚?źinflammatory properties. Inflammatory processes, including astrocytic activation, are implicated in the pathogenesis of different neurodegenerative diseases. Our recent study has indicated that interferon (IFN)‚?źő≥‚?źinduced astrocytic neurotoxicity is mediated, at least in part, by phosphorylation of signal transducer and activator of transcription (STAT) 3. We therefore studied the effects of PPIs on IFN‚?źő≥‚?źinduced neurotoxicity and STAT3 activation of human astrocytes. Both lansoprazole (LPZ) and omeprazole (OPZ) significantly attenuated IFN‚?źő≥‚?źinduced neurotoxicity of human astrocytes and astrocytoma cells. These drugs inhibited IFN‚?źő≥‚?źinduced phosphorylation of STAT 3, but not STAT1. We found that LPZ signi...

Variability in response to clopidogrel: how important are pharmacogenetics and drug interactions?

AbstractClopidogrel is a pro‚?źdrug which is converted to an active metabolite that selectively blocks ADP‚?źdependent platelet activation and aggregation. The main enzyme responsible for activating clopidogrel is the cytochrome P450 (CYP) isoenzyme CYP2C19, which is polymorphic. There is a growing body of literature showing that carriers of variant CYP2C19 alleles have impaired ability to metabolize clopidogrel (i.e. poor metabolizers), which is associated with decreased inhibition of platelet aggregation and increased cardiovascular risk. Some proton pump inhibitors are also metabolized by the CYP2C19 enzyme and often given together with clopidogrel to reduce gastrointestinal side effects. In particular, omeprazole has been shown to inhibit the CYP‚?źmediated metabolism of clopidogrel, a...

Interaction of sorafenib and cytochrome P450 isoenzymes in patients with advanced melanoma: a phase I/II pharmacokinetic interaction study

Conclusions&nbsp;&nbsp;In this patient population, our results demonstrate that exposures of probes of CYP3A4, CYP2D6, or CYP2C19 activity are potentially altered by administration of sorafenib at 400&nbsp;mg twice daily. However, these differences are sufficiently small that a clinically significant inhibition or induction of these important drug metabolizing P450 isoenzymes is unlikely. Clinical and, where possible, drug level monitoring may still be appropriate for drugs of narrow therapeutic range co-administered with sorafenib. Content Type Journal ArticlePages 1-8DOI 10.1007/s00280-011-1585-0Authors Keith T. Flaherty, Abramson Cancer Center, University of Pennsylvania, Philadelphia, PA USAChetan Lathia, Bayer HealthCare Pharmaceuticals, Montville, NJ USAReginald F. Frye...

Separate dosing of clopidogrel and omeprazole may improve platelet inhibition on dual antiplatelet therapy

Dual antiplatelet therapy (aspirin and clopidogrel) constitutes a standard of care after acute myocardial infarction and/or coronary stent implantation. Clopidogrel is converted in the liver by two sequential cytochrome P450 (CYP)-controlled steps to an active metabolite that irreversibly inhibits the platelet P2Y12 adenosine diphosphate (ADP) receptor. Decreased-function genetic variants of the isoenzyme CYP2C19 (carried by about 25‚??30% of Caucasians) were associated with reduced plasma exposure to the clopidogrel active metabolite and attenuated inhibition of platelet aggregation in healthy subjects as well as higher on-treatment residual platelet reactivity and propensity to ischemic events including stent thrombosis after coronary angioplasty . (Source: International Journal of Cardi...

New Quadruple Therapy Regimen More Effective At Eliminating Helicobacter Pylori Infection

The bacterium Helicobacter pylori is associated with benign and malignant diseases of the upper gastrointestinal tract, and increasing antibiotic resistance has made alternative treatments necessary. In a study published Online First by The Lancet, researchers show that 10 days of quadruple therapy with omeprazole plus a single three-in-one capsule containing bismuth subcitrate potassium, metronidazole, and tetracycline (quadruple therapy) is better than the standard 7 day treatment regimen of omeprazole, amoxicillin, and clarithromycin in adults with H pylori infection... (Source: Health News from Medical News Today)<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>

Study evaluates quadruple H pylori eradication regimen versus standard triple regimen

Source: Lancet Area: News According to the findings of a Phase III study published early online in the Lancet, ten days of treatment with quadruple therapy is superior to 7 days of standard triple therapy in the eradication of H pylori.&nbsp; &nbsp; The authors note that international guidelines on Helicobacter pylori (H pylori) recommend treatment with omeprazole and a combination of amoxicillin and clarithromycin if the incidence of clarithromycin resistance is 20% or less; quadruple therapy containing bismuth is proposed in regions with high in-vitro resistance to clarithromycin or metronidazole.&nbsp; The purpose of the current study was to assess the efficacy and safety of a new, single three-in-one capsule containing bismuth subcitrate potassium, metronidazole, and tetracycline,...

Anti-ulcer constituents of Annona squamosa.

This study is the first of its kind to show significant anti-ulcer effect of Annona squamosa. Present study aimed to evaluate the gastroprotective effect of Annona squamosa (AS) and to identify its active constituents. Anti-ulcer activity was evaluated against cold restraint (CRU), pyloric ligation (PL), aspirin (ASP), alcohol (AL) induced gastric ulcer and histamine (HA) induced duodenal ulcer model and further confirmed through in vitro assay of H(+) K(+)-ATPase activity and plasma gastrin level. AS and its chloroform and hexane fraction attenuated ulcer formation in CRU, PL, HA model and displayed anti-secretory activity in vivo through reduced free, total acidity and pepsin in PL, confirmed by in vitro inhibition of H(+) K(+)-ATPase activity with corresponding decrease in plasma gastri...

Clopidogrel with or without Omeprazole in Coronary Disease

New England Journal of Medicine, Volume 364, Issue 7, Page 681-683, February 2011. (Source: New England Journal of Medicine)

Mitochondrial Dependent Apoptosis: Ameliorative Effect of Flunarizine on Ischemia‚??Reperfusion of Celiac Artery-Induced Gastric Lesions in the Rat

Conclusion&nbsp;&nbsp;The gastroprotective effect of flunarizine may be produced due to its inactivation potential of mitochondrial permeability transition pore opening associated with anti-oxidative, calcium regulation along with its anti-apoptotic effect. Content Type Journal ArticlePages 1-8DOI 10.1007/s10620-011-1607-0Authors Arunachalam Muthuraman, Rayat Institute of Pharmacy, Nawanshahr District, Near Railmajra, Ropar, 144533 Punjab IndiaMuthusamy Ramesh, National Institute of Pharmaceutical Education and Research (NIPER), Mohali, Punjab IndiaAshish Chauhan, Rayat Institute of Pharmacy, Nawanshahr District, Near Railmajra, Ropar, 144533 Punjab India Journal Digestive Diseases and SciencesOnline ISSN 1573-2568Print ISSN 0163-2116 (Source: Digestive Diseases and Scie...

OMEPRAZOLE DELAYED-RELEASE (Omeprazole) Capsule, Delayed Release [Apotex Corp]

Updated Date: Feb 14, 2011 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>

Cost-Utility of Aspirin and Proton Pump Inhibitors for Primary Prevention [Original Investigation]

Conclusions&nbsp; Treatment with aspirin for CHD prevention is less costly and more effective than no treatment in men older than 45 years with greater than 10-year, 10% CHD risks. Adding a PPI is not cost-effective for men with average GI bleeding risk but may be cost-effective for selected men at increased risk for GI bleeding. (Source: Archives of Internal Medicine)

Randomized controlled trial of standard versus high‚?źdose intravenous omeprazole after endoscopic therapy in high‚?źrisk patients with acute peptic ulcer bleeding

Conclusion:Intravenous standard‚?źdose omeprazole was inferior to high‚?źdose omeprazole in preventing rebleeding after endoscopic haemostasis for peptic ulcer bleeding. Registration number: NCT00519519 (http://www.clinicaltrials.gov). Copyright ¬© 2011 British Journal of Surgery Society Ltd. Published by John Wiley & Sons, Ltd. (Source: British Journal of Surgery)

PRILOSEC (Omeprazole Magnesium) Capsule, Delayed Release PRILOSEC (Omeprazole Magnesium) Granule, Delayed Release [AstraZeneca LP]

Updated Date: Feb 7, 2011 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

Omeprazole: Hypomagnesaemia in an elderly patient: case report

(Source: Reactions)

OMEPRAZOLE (Omeprazole) Capsule [Med-Health Pharma, LLC]

Updated Date: Feb 4, 2011 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>

Therapeutic effect observation on combined acupuncture and Chinese medicine for reflux esophagitis

Conclusion&nbsp;&nbsp;Combined acupuncture and Chinese medicine can remarkably elevate the plasma gastrin and motilin levels in those with reflux esophagitis, regulate the gastro-esophagus motility, increase the lower esophageal sphincter pressure and thus prevent regurgitation of food. Content Type Journal ArticlePages 26-30DOI 10.1007/s11726-011-0463-yAuthors Daijing Lu, Rehabilitation Department, General Hospital of Hebi Coal Group, Henan, 458000 P. R. China Journal Journal of Acupuncture and Tuina ScienceOnline ISSN 1993-0399Print ISSN 1672-3597 Journal Volume Volume 9 Journal Issue Volume 9, Number 1 (Source: Journal of Acupuncture and Tuina Science)

Furazolidone, amoxicillin and omeprazole with or without bismuth for eradication of Helicobacter pylori in peptic ulcer disease.

Conclusions: Based on the results in this study, furazolidone-based triple therapy (without bismuth) is not recommended for Helicobacter pylori eradication because of the lower eradication rate and unchanged frequency of adverse effects. Thus, we recommend furazolidone, amoxicillin and omeprazole in combination with bismuth for treatment of Helicobacter pylori. PMID: 21480103 [PubMed - in process] (Source: The Turkish Journal of Gastroenterology)

In vivo analysis of mouse gastrin gene regulation in enhanced GFP-BAC transgenic mice

Gastrin is secreted from a subset of neuroendocrine cells residing in the gastric antrum known as G cells, but low levels are also expressed in fetal pancreas and intestine and in many solid malignancies. Although past studies have suggested that antral gastrin is transcriptionally regulated by inflammation, gastric pH, somatostatin, and neoplastic transformation, the transcriptional regulation of gastrin has not previously been demonstrated in vivo. Here, we describe the creation of an enhanced green fluorescent protein reporter (mGAS-EGFP) mouse using a bacterial artificial chromosome that contains the entire mouse gastrin gene. Three founder lines expressed GFP signals in the gastric antrum and the transitional zone to the corpus. In addition, GFP(+) cells could be detected in the fetal...

Involvement of CYP3A4 and CYP2D6 in the metabolism of aconitine using human liver microsomes and recombinant CYP450 enzymes.

In conclusion, aconitine can be transformed into at least six CYP-mediated metabolites in HLMs, CYP 3A4/5 and 2D6 were the most important CYP isoforms responsible for the de-methylation, N-deethylation, dehydrogenation, and hydroxylation of aconitine. PMID: 21277363 [PubMed - as supplied by publisher] (Source: Toxicology Letters)<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>

El Cóndor Pasa: Reflections on the Condor Trial

Chan FK, Lanas A, Scheiman J, et al. (Chinese University of Hong Kong, Prince of Wales Hospital, Hong Kong SAR, China). Celecoxib versus omeprazole and diclofenac in patients with osteoarthritis and rheumatoid arthritis (CONDOR): a randomised trial. Lancet 2010; 376:173‚??179. (Source: Gastroenterology)

Omeprazole: Cutaneous leukocytoclastic vasculitis: case report

(Source: Reactions)

Omeprazole: Acute interstitial nephritis in an elderly patient: case report

(Source: Reactions)

Omeprazole: Recurrent anaphylaxis in an elderly patient: case report

(Source: Reactions)

Partially migrated gastric ring after transected banded vertical gastric bypass

A 59-year-old man who had had bariatric surgery 4 years previously presented with maroon stools and dizziness. The patient was taking a nonsteroidal anti-inflammatory drug (NSAID). He was found to have orthostatic hypotension and tachycardia with normocytic anemia (hemoglobin 7 g/dL; normal 14-18 g/dL); blood test results were otherwise normal. EGD revealed a small gastric pouch that led into the small intestine. A ring that had partially eroded through the stomach wall was identified (). The patient previously had a transected banded vertical gastric bypass, during which a silastic ring was placed around the gastric pouch proximal to the gastrojejunal anastomosis. A clean-based ulcer () also was found on the jejunal side of the anastomosis, without active bleeding or high-risk stigmata. N...<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>

Celecoxib reduced GI events more than diclofenac plus omeprazole in patients with osteoarthritis or rheumatoid arthritis.

Authors: PMID: 21242363 [PubMed - in process] (Source: Annals of Internal Medicine)

Systematic review: proton pump inhibitors for the treatment of gastroesophageal reflux in infants

Source: DARE Area: Evidence > Disease Focused Reviews CRD Summary: The review evaluated the safety and effectiveness of proton pump inhibitors in the treatment of gastro-oesophageal reflux disease in infants and found limited evidence that omeprazole significantly reduced reflux. The review was generally well conducted. The authors' conclusion that there was insufficient evidence for the use of proton pump inhibitors for treatment of gastro-oesophageal reflux disease in infants seems reliable. CRD Commentary: The review addressed a well-defined question in terms of participants, interventions, study design and relevant outcomes. It was unfortunate that only two relevant RCTs were identified and that one of them was of preterm infants (which may be more vulnerable than infants born at te...

Proton Pump Inhibitors in Pediatrics: Evaluation of Efficacy in GERD Therapy.

Authors: Romano C, Chiaro A, Comito D, Loddo I, Ferrau V Gastroesophageal reflux (GER) is defined as the passage of gastric contents into the esophagus. It occurs in healthy infants and can be considered physiological process. Uncomplicated GER can present with recurrent vomiting or regurgitation without any other symptoms and is usually managed by educating, reassuring, and guiding the parent without other intervention. GER disease (GERD) refers to the appearance of troublesome symptoms or complications (erosive esophagitis, ulceration, Barrett's esophagus) and may warrant acid suppression. Proton Pump Inhibitors (PPIs) are the most effective pharmacologic agents available for the treatment of children with GERD. In the pediatric practice only omeprazole, lansoprazole and esomeprazole...

Effect of omeprazole on the pharmacokinetics and toxicities of irinotecan in cancer patients: A prospective cross-over drug‚??drug interaction study

Conclusion: Omeprazole 40mg did not alter the pharmacokinetics and toxicities of irinotecan. This widely used drug can, therefore, be safely administered during a 3-weekly single agent irinotecan schedule. (Source: European Journal of Cancer)

[A hazard scale for severe interactions: a tool for establishing prioritising strategies to improve the safety of the prescription in family medicine.]

CONCLUSIONS: e-PIG is a logarithmic expression of the risk that prescribing a particular drug may produce a severe interaction in a determined setting and time. Its monitoring could become a prioritisation element that may assist the design of strategies for improving the safety of the use of drugs. PMID: 21216049 [PubMed - as supplied by publisher] (Source: Atencion Primaria)<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>

The Use of HepaRG and Human Hepatocyte Data in Predicting CYP Induction Drug-Drug Interactions via Static Equation and Dynamic Mechanistic Modelling Approaches.

Authors: Grime K, Ferguson DD, Riley RJ The method of predicting CYP induction drug-drug interactions (DDIs) from a relative induction score (RIS) calibration has been developed to provide a novel model facilitating predictions for any CYP-inducer substrate combination by inclusion of parameters such as the fraction of hepatic clearance mediated by a specific CYP and fraction of the dose escaping intestinal extraction. In vitro HepaRG CYP3A4 induction data were used as a basis for the approach and a large number of DDIs were well predicted. Primary human hepatocyte data were also used to make predictions, using the HepaRG calibration as a foundation. Similar predictive accuracy suggests that HepaRG and primary hepatocyte data can be used inter-changeably within the same laboratory. A c...

Axorid: new NSAID formulation with built‚?źin GI protection

AbstractAxorid is a new modifiedrelease combination of ketoprofen and omeprazole for patients with a previous history or at risk of NSAID‚?źassociated GI ulceration. Here, Dr Anthony Norman and Professor Christopher Hawkey discuss its place in therapy. Copyright ¬© 2011 Wiley Interface Ltd (Source: Prescriber)

A 78-year-old woman with bilateral tongue necrosis

A 78-year-old woman presented to the emergency department complaining of a sore tongue. Her medical history included essential hypertension managed with atenolol, 100 mg/d, and enalapril, 5 mg/d, osteoporosis managed with calcium and vitamin D (with no past bisphosphonate treatment), and gastroesophageal reflux disease managed with omeprazole, 20 mg/d. Seventeen years before admission, she had suffered from ovarian carcinoma that was treated by chemotherapy and oophorectomy without therapeutic irradiation. She had no known hypersensitivities or drug allergies. The patient reported pain of the right head, neck, face, and shoulder (ranked 8 on a 0 to 10 visual analog scale, with ‚??10‚?Ě the most painful), especially while eating. She also reported fatigue, and visual blurring that had devel...

Intragastric acidity during administration of generic omeprazole or esomeprazole ‚?? a randomised, two‚?źway crossover study including CYP2C19 genotyping

Conclusions‚?? Overall, generic omeprazole 20‚??mg appears to provide a similar intragastric acid control when compared with esomeprazole 20‚??mg. However, esomeprazole might be advantageous in subjects with a rapid CYP2C19 metabolizer status. (Source: Alimentary Pharmacology and Therapeutics)

Pharmacokinetics and dose recommendations of Niaspan(R) in chronic kidney disease and dialysis patients

Conclusions. These data suggest that no dose adjustment of Niaspan&reg; is necessary in patients with renal impairment. Despite an extended-release formulation of NA, we could not detect a delay in tmax especially in dialysis patients. We found no correlation between the incidence of flush and the NUA concentration. Furthermore, there were hints of an interaction with omeprazole. (Source: Nephrology Dialysis Transplantation)<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>

Lower-cost substitute for Zegerid

My doctor prescribed Zegerid for acid reflux. It contains omeprazole plus sodium bicarbonate. My pharmacist says I can take OTC omeprazole plus baking soda and get the same results for less money. A 30-day supply of the prescription is $129. (Source: L.A. Times - Health)

Use of proton pump inhibitors in pregnancy

Source: UK Teratology Information Service Area: Evidence > Drugs in Pregnancy SUMMARY: &nbsp;Proton Pump Inhibitors (PPIs) are used in the management of dyspepsia, gastro-oesophageal reflux and peptic ulceration.&nbsp; Of the five PPIs licensed for use in the United Kingdom (esomeprazole, omeprazole, lansoprazole, pantoprazole and rabeprazole), the largest number of documented exposures during pregnancy have occurred with omeprazole.&nbsp; The limited available data do not indicate an increased risk of adverse fetal effects following in utero exposure to omeprazole. &nbsp; In the case of dyspepsia and gastro-oesophageal reflux, symptoms should be managed by dietary methods and antacids/alginates in the first instance.&nbsp; If acid suppression is necessary, ranitidine is preferred.&nb...

Abstracts from Around the World

Prior studies demonstrated the efficacy of proton pump inhibitor (PPI) therapy in decreasing upper gastrointestinal (UGI) tract bleeding complications related to aspirin use. In contrast, there are no data on the efficacy of PPI therapy to prevent UGI complications with dual antiplatelet therapy‚??aspirin plus clopidogrel (75 mg). This multicenter trial randomly assigned patients with indication for dual antiplatelet therapy to clopidogrel in combination with either omeprazole (25 mg) or placebo in addition to low-dose aspirin (75‚??325 mg daily). The primary GI end point was a composite of overt or occult bleeding, symptomatic gastroduodenal ulcers, erosions, obstruction, or perforation. A primary cardiovascular end point was also determined. An analysis of cardiovascular complications is...

Formulation and evaluation of omeprazole tablets for duodenal ulcer

A Choudhury, S Das, S Bahadur, S Saha, A RoyIndian Journal of Pharmaceutical Sciences 2010 72(4):491-494Omeprazole pellets containing mucoadhesive tablets were developed by direct punch method. Three mucoadhesive polymers namely hydroxypropylemethylcellulose K4M, sodium carboxy methylcellulose, carbopol-934P and ethyl cellulose were used for preparation of tablets which intended for prolong action may be due to the attachment with intestinal mucosa for relief from active duodenal ulcer. Mucoadhesive tablets were coated with respective polymer and coated with Eudragit L100 to fabricate enteric coated tablets. The prepared tablets were evaluated for different physical parameters and dissolution study were performed in three dissolution mediums like 0.1N hydrochloric acid for 2h, pH 6.5 and p...

Gastrin‚?źReleasing Peptide Receptor Antagonist or N‚?źacetylcysteine combined with Omeprazol Protect against Mitochondrial Complex II Inhibition in a Rat Model of Gastritis

Abstract:‚?? The pathophysiology of gastritis involves an imbalance between gastric acid attack and mucosal defence. In addition, the gastric mucosal injury results in adenosine triphosphate (ATP) depletion leading to mitochondrial dysfunction. Several studies have shown the association of mitochondrial disorders with gastrointestinal dysfunction. In the present study, we investigated the activity of mitochondrial respiratory chain complexes activity in the stomach of rats with gastritis induced by indomethacin (IDM) and treated with omeprazole (OM), N‚?źacetylcysteine (NAC) and the gastrin‚?źreleasing peptide receptor (GRPR) antagonist RC‚?ź3095. Adult male Wistar rats were pre‚?źtreated for 7‚??days with OM, NAC, RC‚?ź3095, combination of OM plus RC‚?ź3095, OM plus NAC and water (control...<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>

Lansoprazole/omeprazole: Hypersensitivity vasculitis and glomerulonephritis in an elderly patient: case report

(Source: Reactions)

When One Medication May Not Be Enough

You may be taking an antacid or proton pump inhibitor or h2 blocker, and not finding relief. This may be because a combination of those remedies would control GERD symptoms better. Each type of drug works in a different way, and alone may only control some of the symptoms. Your doctor is the best source to decide which medications would work best for you GERD symptoms. What are these types of medications? Antacids Antacids work by neutralizing acid in the stomach. They are usually the first remedy doctors will recommend patients take to relief heartburn symptoms. Antacids include Rolaids, Maalox, Mylanta, Tums, Gaviscon, and Chooz. H2 Blockers H2 blockers, also called H2 receptor agonists, are medicines that reduce the amount of acid the stomach produces. H2 blockers include Axid, Pe...

Randomised clinical trial: efficacy of the addition of a prokinetic, mosapride citrate, to omeprazole in the treatment of patients with non‚?źerosive reflux disease‚??‚??‚??a double‚?źblind, placebo‚?źcontrolled study

Conclusion‚?? The addition of mosapride to omeprazole was not more effective than omeprazole alone. (Source: Alimentary Pharmacology and Therapeutics)

Inhibition of the antithrombotic effects of clopidogrel by proton pump inhibitors: Facts or fancies?

Authors: Lettino M Clopidogrel plus aspirin is considered the antiplatelet treatment of choice in patients with acute coronary syndrome, whether or not they are undergoing a percutaneous coronary intervention (PCI). The same treatment is mandatory in all patients undergoing a PCI with stent implantation. Clopidogrel is a pro-drug that needs metabolic activation through a cytochrome P450-dependent pathway, with an extensive involvement of the CYP 2C19 isoenzyme. Proton pump inhibitors (PPIs) reduce the risk of gastrointestinal bleeding in patients receiving dual antiplatelet therapy. In the past two years some scientific evidences have suggested a possible negative interference of PPIs on antiplatelet effect of clopidogrel because of the competitive inhibition of the CYP 2C19 isoenzyme....

A Comprehensive Development Strategy in Buccal Drug Delivery.

Authors: Figueiras A, Pais AA, Veiga FJ This work combines several methods in an integrated strategy to develop a matrix for buccal administration. For this purpose, tablets containing selected mucoadhesive polymers loaded with a model drug (omeprazole), free or in a complexed form with cyclodextrins, and in the absence and presence of alkali agents were subjected to a battery of tests. Mucoadhesion studies, including simple factorial analysis, in vitro release studies with both model-dependent and model-independent analysis, and permeation studies were performed. Mucoadhesive profiles indicated that the presence of the drug decreases the mucoadhesion profile, probably due its hydrophobic character. In tablets loaded with the drug complexed with ő≤-cyclodextrin or methyl-ő≤-cyclodextri...<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>

Regulation of gastric acid secretion by the serum and glucocorticoid inducible kinase isoform SGK3

Conclusions&nbsp;&nbsp;SGK3 suppresses gastric acid secretion, an effect presumably mediated by the stimulation of protein kinase A with the subsequent activation of K+ channels. Content Type Journal ArticleDOI 10.1007/s00535-010-0348-8Authors Venkanna Pasham, Department of Physiology, University of T√ľbingen, Gmelinstr. 5, 72076 T√ľbingen, GermanyAnand Rotte, Department of Physiology, University of T√ľbingen, Gmelinstr. 5, 72076 T√ľbingen, GermanyMadhuri Bhandaru, Department of Physiology, University of T√ľbingen, Gmelinstr. 5, 72076 T√ľbingen, GermanyMelanie Eichenm√ľller, Department of Physiology, University of T√ľbingen, Gmelinstr. 5, 72076 T√ľbingen, GermanyHenning Fr√∂hlich, Department of Physiology, University of T√ľbingen, Gmelinstr. 5, 72076 T√ľbingen, GermanyAndreas F...

PPI use during early pregnancy not associated with significantly increased risk of birth defects

Source: N Engl J Med Area: News A large observational study did not find a significant increase in the risk of birth defects in infants born to mothers who took proton-pump inhibitors (PPI) during early pregnancy. &nbsp; PPI are likely taken by pregnant women relatively commonly, however there is limited information on the safety of these drugs during pregnancy: the FDA classes omeprazole as category C on the basis of animal studies that showed adverse effects at high doses; other PPI are category E as animal studies showed no effects but there are no studies in humans. The authors of this report used linked Danish registries to examine whether there was any association between PPI use in the first trimester of pregnancy and major birth defects. They conducted a cohort study involving...

Mom's heartburn meds not tied to birth defects

NEW YORK (Reuters Health) - A nationwide study from Denmark finds pregnant women have little reason to be concerned about birth defects when taking omeprazole and similar heartburn drugs. (Source: Reuters: Health)

How should continuous infusions of branded proton pump inhibitors be given for acute upper gastrointestinal bleeding?

Source: Wessex Drug and Medicines Information Centre Area: Evidence > Medicines Q & A .&nbsp;Current guidance recommends that high-dose intravenous proton pump inhibitor (PPI) therapy (80mg bolus followed by 8mg/hour infusion for 72 hours) should be used in patients with major peptic ulcer bleeding following endoscopic haemostatic therapy. &nbsp; .&nbsp;Omeprazole and pantoprazole are not licensed to be given by continuous intravenous infusion&nbsp;and use in this way is therefore the responsibility of the prescribing physician. Intravenous esomeprazole is licensed for the prevention of rebleeding following therapeutic endoscopy for acute bleeding gastric or duodenal ulcers. &nbsp; .&nbsp;After administration of the initial 80mg dose, the continuous infusion can be prepared by rec...

Myocardium functional recovery protection by omeprazole after ischemia-reperfusion in isolated rat hearts

OBJETIVO: Analisar efeitos do omeprazol na prote√ß√£o da recupera√ß√£o funcional de cora√ß√Ķes isolados de ratos submetidos √† les√£o de isquemia-reperfus√£o. M√?TODOS: Foram estudados 12 ratos Wistar, peso corp√≥reo m√©dio de 280g. Ap√≥s anestesia com inje√ß√£o intra-abdominal de 10mg de cetamina e 2mg de xilazina, os cora√ß√Ķes foram removidos e mantidos em perfus√£o com solu√ß√£o Krebs-Henseleit (95%O2 e 5% CO2, 37¬ļC, 110-120mmHg de press√£o de perfus√£o e press√£o diast√≥lica de 8 mmHg) em sistema Langendorff, modificado, descart√°vel, modelo FCSFA-ServCor (Comex Ltda.). Os seis cora√ß√Ķes do Grupo I (GI) e os seis do Grupo II (GII) foram submetidos a 20 minutos de isquemia e 30 minutos de reperfus√£o. Nos cora√ß√Ķes do Grupo II, imediatamente antes da isquemia, foram administrados vi...<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>

OMEPRAZOLE/SODIUM BICARBONATE (Omeprazole, Sodium Bicarbonate) Powder, For Suspension OMEPRAZOLE/SODIUM BICARBONATE (Omeprazole, Sodium Bicarbonate) Capsule [Prasco, Laboratories]

Updated Date: Nov 22, 2010 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

Review Article: Combination of Clopidogrel and Proton Pump Inhibitors: Implications for Clinicians

Conclusions: Controversies exist on a potential drug-drug interaction between clopidogrel and PPIs. Although further studies are warranted, several studies indicated that there was a drug-drug interaction through this combination therapy with detrimental clinical outcomes and increased costs. Studies suggested that the use of a PPI may make clopidogrel less effective resulting in a higher risk of myocardial infarction, stroke, or death. Until additional information becomes available clinicians should consider discontinuing PPI use if no clear indication is documented. Alternative options like H2-receptor antagonists should be considered. Upon availability, genetic testing may provide additional valuable information. (Source: Journal of Cardiovascular Pharmacology and Therapeutics)

Enantioseparation of rabeprazole and omeprazole by nonaqueous capillary electrophoresis with an ephedrine-based ionic liquid as the chiral selector.

Authors: Ma Z, Zhang L, Lin L, Ji P, Guo X An ephedrine-based chiral ionic liquid, (+)-N,N-dimethylephedrinium-bis(trifluoromethanesulfon)imidate ([DMP](+) [Tf(2) N](-) ), served as both chiral selector and background electrolyte in nonaqueous capillary electrophoresis. The enantioseparation of rabeprazole and omeprazole was achieved in acetonitrile-methanol (60:40‚??v/v) containing 60‚??mm[DMP](+) [Tf(2) N](-) . The influences of separation conditions, including the concentration of [DMP](+) [Tf(2) N](-) , the electrophoretic media and the buffer, on enantioseparation were evaluated. The mechanism of enantioseparation was investigated and discussed. Ion-pair interaction and hydrogen bonding may be responsible for the main separation mechanism. Copyright ¬© 2010 John Wiley & Sons, ...

Spaced PA 32540 With Clopidogrel Cuts Pharmacodynamic Interaction Compared With Concurrent Administration

Dual antiplatelet therapy (DAPT) with PA32540 and clopidogrel demonstrates a decrease in drug-drug interaction when spaced 10 hours apart in healthy volunteers, according to phase 1 results released at the American Heart Association (AHA) Scientific Sessions 2010. PA 32540 is an investigational coordinated-delivery tablet of immediate-release omeprazole (40 mg), layered around enteric-coated aspirin (325 mg). The product was developed to provide the cardiovascular benefits of aspirin with a lower incidence of gastric ulcers than enteric-coated aspirin alone... (Source: Health News from Medical News Today)

Sequential Metronidazole‚?źFurazolidone or Clarithromycin‚?źFurazolidone Compared to Clarithromycin‚?źBased Quadruple Regimens for the Eradication of Helicobacter pylori in Peptic Ulcer Disease: A Double‚?źBlind Randomized Controlled Trial

Conclusion:‚?? Furazolidone can replace clarithromycin in H.¬†pylori eradication regimens because of lack of development of resistance and very low cost. (Source: Helicobacter)<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>

Antiplatelet drug interactions

Abstract.‚?? Mackenzie IS, Coughtrie MWH, MacDonald TM, Wei L. (Medicines Monitoring Unit (MEMO); and Centre for Oncology & Molecular Medicine, Division of Medical Sciences, University of Dundee, Ninewells Hospital & Medical School; Dundee, UK). Antiplatelet drug interactions (Review‚?źSymposium). J Intern Med 2010; 268: 516‚??529.Both laboratory studies in healthy volunteers and clinical studies have suggested adverse interactions between antiplatelet drugs and other commonly used medications. Interactions described include those between aspirin and ibuprofen, aspirin and other nonsteroidal anti‚?źinflammatory drugs (NSAIDs), and the thienopyridine, clopidogrel, and drugs inhibiting CYP2C19, notably the proton pump inhibitors (PPI) omeprazole and esomeprazole. Other interactions b...

OMEPRAZOLE (Omeprazole And Sodium Bicarbonate) Capsule OMEPRAZOLE (Omeprazole And Sodium Bicarbonate) Capsule [Par Pharmaceutical Inc.]

Updated Date: Nov 12, 2010 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

Interaction of Clopidogrel and Omeprazole

New England Journal of Medicine, Volume 363, Issue 20, Page 1977, November 2010. (Source: New England Journal of Medicine)

Santarus Reports 3Q Loss On Sales Drop, Costs

From Associated Press (November 9, 2010) SAN DIEGO -- Drug developer Santarus Inc. reported a third-quarter loss Monday on lower revenue because of generic Zegerid competition and higher costs. It also forecast 2010 revenue below analysts&rsquo;... (Source: Drugs.com - Pharma News)

CYP1D1; pseudogenized in human; is expressed and encodes a functional drug-metabolizing enzyme in cynomolgus monkey.

In this study, we identified CYP1D1 cDNA, highly identical (nearly 95%) to human CYP1D1P sequence, in cynomolgus monkey, a species frequently used in drug metabolism studies due to its evolutionary closeness to human. The amino acid sequence deduced from cynomolgus monkey CYP1D1 cDNA shared the high sequence identity (91%) with human CYP1D1P (postulated from the gene sequence), and the highest sequence identity (44-45%) with CYP1A1 and CYP1A2 among cynomolgus monkey P450s. CYP1D1 mRNA was most abundantly expressed in liver, followed by kidney, and jejunum. The hepatic expression level of CYP1D1 mRNA was comparable to that of CYP1A1 mRNA and much higher than that of CYP1A2 mRNA. CYP1D1 was barely detectable in immunoblots of cynomolgus monkey liver. Cynomolgus monkey CYP1D1 mRNA was induced...<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>

Effect of omeprazole on the expression of transcription factors in osteoclasts and osteoblasts.

Authors: Hyun JJ, Chun HJ, Keum B, Seo YS, Kim YS, Jeen YT, Lee HS, Um SH, Kim CD, Ryu HS, Kim SG, Jung WW The use of proton pump inhibitors (PPIs) seems to be related to increased fracture risk but the mechanism is unclear. In an effort to clarify the mechanism, we evaluated the effect of omeprazole, a representative of the PPIs, on the expression of transcription factors in osteoclasts and osteoblasts. Murine RAW264.7 and MC3T3-E1 cells were used for osteoclast and osteoblast analysis, to which various concentrations of omeprazole were added. RAW264.7 cells with ‚?•3 nuclei were considered tartrate-resistant acid phosphatase (TRAP)-positive, i.e. activated osteoclasts. Expressions of the calcitonin receptor (CTR), c-fos, nuclear factor of activated T-cells, cytoplasmic 1 (NFATc1), an...

In vivo analysis of mouse gastrin gene regulation in enhanced GFP-BAC transgenic mice.

Authors: Takaishi S, Shibata W, Tomita H, Jin G, Yang X, Ericksen R, Dubeykovskaya Z, Asfaha S, Quante M, Betz KS, Shulkes A, Wang TC Gastrin is secreted from a subset of neuroendocrine cells residing in the gastric antrum known as G cells, but low levels are also expressed in fetal pancreas and intestine and in many solid malignancies. While past studies have suggested antral gastrin is transcriptionally regulated by inflammation, gastric pH, somatostatin and neoplastic transformation, the transcriptional regulation of gastrin has not previously been demonstrated in vivo. Here, we describe the creation of an enhanced green fluorescent protein reporter (mGAS-EGFP) mouse using a bacterial artificial chromosome that contains the entire mouse gastrin gene. Three founder lines expressed GF...

How I Get My Vitamin B12

Dear Health Conscious Reader, I was trying to go through my favorite news websites this morning, but I didn‚??t get very far. Don‚??t worry, I feel fine. It‚??s just that I kept seeing the same story over and over. Almost 70 articles on the same study‚?¶ and each article with nearly the same headline: ‚??Vitamin B12 Can Prevent Alzheimer‚??s.‚?Ě Don‚??t get me wrong‚?¶ it‚??s true, and it‚??s a great thing. But it‚??s not really news. We‚??ve known the benefits of B12 for years. To me, the real importance of the study is that it deals one more body blow to modern diet recommendations, which tell us that protein and fat are the enemies of good health. The story the media should be telling is that protein is where nature meant us to get our B12 from. Not from processed grains with added vit...

Omeprazole: Acute interstitial nephritis: 2 case reports

(Source: Reactions)

Omeprazole: Acute liver injury: case report

(Source: Reactions)<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>

Efficacy of Oral Famotidine and 2 Omeprazole Formulations for the Control of Intragastric pH in Dogs

Conclusion: Oral omeprazole tablet and RP provide superior gastric acid suppression to famotidine, and should therefore be considered more effective for the treatment of acid related disorders in dogs. (Source: Journal of Veterinary Internal Medicine)

New Treatment for Bleeding Ulcers Reduces Surgery, Death Rates

The heartburn drugs Prilosec and Prevacid reduce the risk of bleeding, abdominal surgery and death when used to treat life-threatening peptic ulcers, according to an updated systematic review of data. 1/24 (Source: Health Behavior News Service)

Antiplatelet Therapy in Acute Coronary Syndrome (ACS) and PCI: Practical Strategies to Improve Outcomes

Abstract: Antiplatelet therapy is essential to reduce the risk for ischemic events in patients with acute coronary syndromes (ACS). A fundamental issue in prescribing antiplatelet therapy remains balancing an increased risk for bleeding with efficacy in thrombosis prevention, emphasizing the need to individualize ACS treatment. The current standard is the combination of aspirin with clopidogrel and/or a glycoprotein IIb/IIIa inhibitor. However, evidence indicates reduced platelet inhibition with clopidogrel in carriers of certain genotypes of cytochrome P450 2C19, and American and European regulators recently issued warnings concerning the concomitant use of clopidogrel with drugs that inhibit cytochrome P450 2C19, such as the proton pump inhibitor omeprazole. Clinical trial data illustrat...

De novo erosive esophagitis in duodenal ulcer patients related to pre-existing reflux symptoms, smoking, and patient age, but not to Helicobacter pylori eradication: a one-year follow-up study.

CONCLUSIONS. H. pylori eradication did not influence the incidence of erosive esophagitis in patients with duodenal ulcer during a one-year follow-up period. Pre-existing nonerosive gastroesophageal reflux disease, smoking, and older age are important predictors of de novo development of erosive esophagitis. PMID: 20966617 [PubMed - as supplied by publisher] (Source: Medicina (Kaunas))

Comparison of the protective effects of various antiulcer agents alone or in combination on indomethacin-induced gastric ulcers in rats.

Authors: Izzettin FV, Sancar M, Okuyan B, Apikoglu-Rabus S, Cevikbas U The aim of this study which was structured with the objective of determination of the optimum protective therapy against the long term NSAID therapy-induced ulcers was to compare the gastro-protective effects of various antiulcer drugs (ranitidine, omeprazole, bismuth and misoprostol) alone or in combination with each other in different doses on indomethacin-induced gastric ulcers in rats. In this experimental study the protective effect of misoprostol (100őľg/kg/day and 10őľg/kg/day i.g.), omeprazole (5mg/kg/day and 1.5mg/kg/day i.p.), ranitidine (40mg/kg/day and 10mg/kg/day i.p.), bismuth (70mg/kg/day and 15mg/kg/day i.g.), combinations of misoprostol (10őľg/kg/day i.g.) plus omeprazole (1.5mg/kg/day i.p.) and mis...<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>

Pharmacist- versus physician-acquired medication history: a prospective study at the emergency department

Conclusion This large prospective study demonstrates that medication history acquisition is very often incomplete in the ED. A structured form and a standardised method is necessary. Pharmacists are especially suited to acquire and supervise accurate medication histories, as they are educated and familiar with commonly used drugs. (Source: Quality and Safety in Health Care)

Rhabdomyolysis in a patient receiving ranolazine and simvastatin.

Conclusion A 63-year-old man with a history of chronic renal impairment on a stable dosage of simvastatin developed rhabdomyolysis after the addition of ranolazine to his medication regimen. PMID: 20966146 [PubMed - in process] (Source: American Journal of Health-System Pharmacy : AJHP)

ZEGERID (Omeprazole, Sodium Bicarbonate) Powder, For Suspension ZEGERID (Omeprazole, Sodium Bicarbonate) Capsule [Santarus, Inc.]

Updated Date: Oct 21, 2010 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

FDA Underscores Plavix Warning

The FDA said it plans to reiterate its warning that patients taking anticlotting drug Plavix should avoid also taking the heartburn drug Prilosec. (Source: WSJ.com: Health)

FDA Repeats Plavix Warning

The FDA said it plans to reiterate its warning that patients taking anticlotting drug Plavix should avoid also taking the heartburn drug Prilosec. (Source: WSJ.com: Health)<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>

50 Years Ago in The Journalof Pediatrics: A Note on Vitamin B12 Deficiency Associated with Disease of the Small Intestine: Observations on an Infant Following Extensive Small Bowel Resection

Dallman PR, Diamond LK. J Pediatr 1960;57:689-94 Fifty years ago, Dallman et al described a 3.5-year-old boy with jejunal atresia who underwent extensive intestinal resection (ileum, ileocecal valve, and ascending colon) soon after birth. He had subsequent development of anemia, developmental delay, and severe malnutrition. He was successfully treated with intramuscular vitamin B12 (cobalamin), with improvement noted in his anemia (which resolved in 14 days), appetite, and development. The only known role for cobalamin in humans involves methylcobalamin (transfer of methyl from methyltetrahydrofolic acid to methionine) and deoxyadenosylcobalamin (proprionate metabolism). Active absorption of cobalamin is complex, requiring gastric pepsin to release cobalamin from food and haptocorrin to c...

FDA to Reiterate Warning on Plavix, Prilosec

The FDA said it plans to reiterate its warning that patients taking anticlotting drug Plavix should avoid also taking the heartburn drug Prilosec. (Source: WSJ.com: Health)

Domperidone/lansoprazole/omeprazole: Hyperprolactinaemia and galactorrhoea: case report

(Source: Reactions)

Adding a PPI to Dual Antiplatelets Cut Bleeding

Major Finding: The rate of gastrointestinal bleeding was 1.1% in patients taking omeprazole, compared with 2.9% in patients taking placebo in addition to their regular clopidogrel-plus-aspirin regimen. The number of cardiovascular events was nearly identical, with 54 in the placebo group and 55 in the omeprazole group. (Source: Family Practice News)

Empirical levofloxacin-containing versus clarithromycin-containing sequential therapy for Helicobacter pylori eradication: a randomised trial

Conclusion In an area with &gt;15% prevalence of clarithromycin resistant H pylori strains, a levofloxacin-containing sequential therapy is more effective, equally safe and cost-saving compared to a clarithromycin-containing sequential therapy. (Source: Gut)<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>

Follow-Up: An Interview on Clopidogrel and Omeprazole

(No abstract is available for this citation) (Source: Physician's First Watch current issue)

Proton Pump Inhibitors Now Safe with Plavix?

In research released in February 2009, there were concerns that taking proton pump inhibitors when taking Plavix (clopidogrel) could inhibit how Plavix worked in the body. However, in a new study, researchers say that it is now safe to take PPIs when taking Plavix. "This is reassuring data that there is not any clinically significant interaction between clopidogrel and PPIs," announced lead researcher Dr. Deepak Bhatt, chief of cardiology at the Veterans Affairs Boston Healthcare System. He adds, "This is contrary to prior observational, non-randomized studies that showed that if you took clopidogrel and a PPI, it blunted the ability of clopidogrel to protect from things like heart attack." The study, which spanned six months, also indicated that patients taking PPI's along with Plavix h...

Clopidogrel with or without omeprazole in coronary artery disease

(Source: NHS Evidence - Gastroenterology and liver diseases - News)

Bisphosphonates/glucocorticoids/omeprazole: Femoral fractures: case report

(Source: Reactions)

COGENT: No significant CV interaction between omeprazole and placebo

Trial findings showing no clinically significant cardiovascular interaction between the proton pump inhibitor omeprazole and clopidogrel antiplatelet therapy have been published in the New England Journal of Medicine. (Source: MedWire News - Cardiology)<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>

COGENT Published: Lead Investigator Says He'll Use a PPI in Patients on Dual Antiplatelet Therapy

Patients on dual antiplatelet therapy had a significant reduction in GI events with omeprazole and no increase in cardiovascular events in the first randomized trial of PPI use with clopidogrel. And a new mechanistic study suggests that the clopidogrel-omeprazole interaction may be dose dependent. Heartwire (Source: Medscape Today Headlines)

PPI Gives Big Protection in Dual Antiplatelet Tx (CME/CE)

(MedPage Today) -- A pill that combines omeprazole and clopidogrel as part of a dual antiplatelet regimen significantly reduced the risk of gastrointestinal bleeding or other adverse events compared with standard therapy, researchers reported. (Source: MedPage Today Cardiovascular)

Clopidogrel with or without Omeprazole in Coronary Artery Disease

New England Journal of Medicine, Volume 0, Issue 0, Ahead of Print. (Source: New England Journal of Medicine)

Data on Clopidogrel and Omeprazole Offer 'Reassurance' on Cardiovascular Risk, Researchers Say

(No abstract is available for this citation) (Source: Physician's First Watch current issue)

Clopidogrel plus omeprazole: fewer GI bleeds and no difference in cardiovascular benefits

Source: N Engl J Med Area: News Combining omeprazole with clopidogrel as part of dual anti-platelet therapy reduces the rate of serious gastro-intestinal (GI) events without affecting cardiovascular events, according to a controlled trial. &nbsp; The adverse effect of greatest concern with dual anti-platelet therapy is GI bleeding: acid-suppressive therapy reduces this risk, however, recent studies have linked the use of proton-pump inhibitors with a reduction in cardiovascular benefits from clopidogrel. Before these studies were published, a small US pharmaceutical company was carrying out a large placebo-controlled trial of a combination product including clopidogrel plus omeprazole. The trial was terminated early, but results are available for 75% of the original intended patient n...<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>

Clopidogrel with or without Omeprazole in Coronary Artery Disease

New England Journal of Medicine, Volume 0, Issue 0, Ahead of Print. (Source: New England Journal of Medicine)

COGENT published: Lead investigator says he'll use a PPI in patients on dual antiplatelet therapy

Patients on dual antiplatelet therapy had a significant reduction in GI events with omeprazole and no increase in cardiovascular events in the first randomized trial of PPI use with clopidogrel. And... For complete story visit theheart.org. (Source: theHeart.org)

Omeprazole Shows Benefit With Aspirin, Clopidogrel

Omeprazole may be associated with a lower risk of upper gastrointestinal bleeding in patients taking aspirin and clopidogrel, without a significant increase in risk of cardiovascular events, according to research published online Oct. 6 in the New England Journal of Medicine. (Source: Modern Medicine)

Rebamipide has the potential to reduce the intensity of NSAID-induced small intestinal injury: a double-blind, randomized, controlled trial evaluated by capsule endoscopy

Conclusions&nbsp;&nbsp;Rebamipide co-therapy had the potential to reduce the intensity of small intestinal injury induced by 2-week administration of diclofenac. Content Type Journal ArticleDOI 10.1007/s00535-010-0332-3Authors Shunji Fujimori, Division of Gastroenterology, Department of Internal Medicine, Nippon Medical School, 1-1-5 Sendagi, Bunkyo-ku, Tokyo, 113-8603 JapanYoko Takahashi, Division of Gastroenterology, Department of Internal Medicine, Nippon Medical School, 1-1-5 Sendagi, Bunkyo-ku, Tokyo, 113-8603 JapanKatya Gudis, Division of Gastroenterology, Department of Internal Medicine, Nippon Medical School, 1-1-5 Sendagi, Bunkyo-ku, Tokyo, 113-8603 JapanTsuguhiko Seo, Division of Gastroenterology, Department of Internal Medicine, Nippon Medical School, 1-1-5 Sendagi, ...

Gut Check: Test Your Gastro Knowledge

Test your knowledge of a range of common GI complaints. Duke gastroenterologist Rahul Shimpi, MD, helps digest the information. 1. True or false? Diet plays an important role in gastrointestinal complaints. Often true -- but not always. ‚??though I‚??m not convinced there‚??s a dietary link with all things digestive,‚?Ě says Shimpi, ‚??there are definitely food intolerances like lactose behind a lot of GI symptoms." "I have patients keep a food diary to see if they can link consumption to their discomfort. Diet definitely plays a role in functional dyspepsia (indigestion), where eating lower-fat foods and smaller, more frequent meals helps.‚?Ě 2. Celiac disease means the body cannot tolerate: A. DairyB. BeansC. ProteinD. GlutenD. Gluten is a specific protein in wheat, barley, and rye that ...<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>

Intermittent use of pantoprazole and famotidine in severe hypomagnesaemia due to omeprazole.

Authors: Fernández-Fernández FJ, Sesma P, Caínzos-Romero T, Ferreira-González L No abstract available. PMID: 21071783 [PubMed - as supplied by publisher] (Source: The Netherlands Journal of Medicine)

Anti-ulcer & antioxidant activities of Hedranthera barteri {(Hook F.) Pichon} with possible involvement of H(+), K(+) ATPase inhibitory activity.

Authors: Onasanwo SA, Singh N, Olaleye SB, Mishra V, Palit G Background & objective: Hedranthera barteri (HB) is used in folk medicine as a vermifuge, laxative and an anti-inflammatory agent. The aim of this study was to evaluate the anti-ulcer and antioxidant properties of the dichloromethane fraction of HB root (DMHBR). Methods: Anti-ulcerogenic activity was assessed in cold-restraint (CRU), aspirin (ASP), alcohol (AL), pyloric ligation (PL) induced gastric ulcer models in rats and histamine-induced duodenal ulcer (HST) in guinea pigs. The effect of DMHBR (100 mg/kg) on gastric juice for free and total acidity, peptic activity and mucin secretion, using the pylorus ligated model, were evaluated. The H(+), K(+)-ATPase activity was assayed in gastric microsomes, spectrophotometrica...

PRILOSEC (Omeprazole Magnesium) Capsule, Delayed Release PRILOSEC (Omeprazole Magnesium) Granule, Delayed Release [AstraZeneca LP]

Updated Date: Sep 27, 2010 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

Antibacterials/betamipron/omeprazole: Acute interstitial nephritis (first report with panipenem/betamipron): 2 case reports

(Source: Reactions)

Risk factors and prevention of upper gastrointestinal hemorrhage after a coronary artery bypass grafting operation

Conclusion&nbsp;&nbsp;Advanced age and extracorporeal circulation time were risk factors for upper GI bleeding after CABG, and the prophylactic use of omeprazole decreased the rate of upper GI bleeding. Content Type Journal ArticleDOI 10.1007/s00595-009-4160-0Authors Hongguang Fan, Department of Cardiovascular Surgery and Research Center for Cardiovascular Regenerative Medicine, Cardiovascular Institute and Fuwai Hospital, Peking Union Medical College and Chinese Academy of Medical Sciences, 167A Beilishi Road, Xi Cheng District, Beijing, 100037 PR ChinaZhe Zheng, Department of Cardiovascular Surgery and Research Center for Cardiovascular Regenerative Medicine, Cardiovascular Institute and Fuwai Hospital, Peking Union Medical College and Chinese Academy of Medical Sciences, 167...<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>

Comparative study of proton pump inhibitors on dexamethasone plus pylorus ligation induced ulcer model in rats

A. H. M. Thippeswamy, M Sajjan, MB Palkar, BC Koti, A.H.M. ViswanathaswamyIndian Journal of Pharmaceutical Sciences 2010 72(3):367-371The present study was designed to compare ulcer protective effect of proton pump inhibitors viz. omeprazole, rabeprazole and lansoprazole against dexamethasone plus pylorus ligation induced ulcer model. Dexamethasone (5 mg/kg) was used as an ulcerogen. Dexamethasone suspended in 1&#x0025; CMC in water was given orally to all the rats 15 min after the pylorus ligation. Omeprazole (20 mg/kg), rabeprazole (20 mg/kg), and lansoprazole (20 mg/kg) were administered by oral route 30 min prior to ligation was used for ulcer protective studies, gastric secretion and mucosal studies. Effects of proton pump inhibitors were determined by the evaluation of various bioche...

Hypotension and bradycardia associated with concomitant tizanidine and lisinopril therapy.

Conclusion The addition of tizanidine in a patient receiving long-term treatment with lisinopril was associated with severe hypotension and bradycardia. PMID: 20852161 [PubMed - in process] (Source: American Journal of Health-System Pharmacy : AJHP)

Comparative study of proton pump inhibitors on dexamethasone plus pylorus ligation induced ulcer model in rats

A. H. M. Thippeswamy, M Sajjan, MB Palkar, BC Koti, A.H.M. ViswanathaswamyIndian Journal of Pharmaceutical Sciences 2010 72(3):367-371The present study was designed to compare ulcer protective effect of proton pump inhibitors viz. omeprazole, rabeprazole and lansoprazole against dexamethasone plus pylorus ligation induced ulcer model. Dexamethasone (5 mg/kg) was used as an ulcerogen. Dexamethasone suspended in 1&#x0025; CMC in water was given orally to all the rats 15 min after the pylorus ligation. Omeprazole (20 mg/kg), rabeprazole (20 mg/kg), and lansoprazole (20 mg/kg) were administered by oral route 30 min prior to ligation was used for ulcer protective studies, gastric secretion and mucosal studies. Effects of proton pump inhibitors were determined by the evaluation of various bioche...

Case report: Hypotension and bradycardia associated with concomitant tizanidine and lisinopril therapy

Source: American Journal of Health-System Pharmacy Area: News In this case report, the authors describe an 85 year old male presenting with hypotension (60/32mmHg) and bradycardia (37 beats per minute).&nbsp; He had been started on tizanidine (2mg TDS) for severe chronic back pain two days prior to admission, and he had taken three doses of this before being seen at the hospital.&nbsp; He was also taking a number of other medicines, including paracetamol, chlorpromazine, citalopram, finasteride, lidocaine patch, lisinopril, metformin, pramipexole, omeprazole, simvastatin, theophylline, diclofenac topical gel, hydrocodone-acetaminophen, and ondansetron.&nbsp; A number of his regular medicines were withheld and IV fluids administered; his vital signs improved within 24 hours.&nbsp; Tizanidi...

Differential Effects of Omeprazole and Pantoprazole on the Pharmacodynamics and Pharmacokinetics of Clopidogrel in Healthy Subjects: Randomized, Placebo-Controlled, Crossover Comparison Studies.

Authors: Angiolillo DJ, Gibson CM, Cheng S, Ollier C, Nicolas O, Bergougnan L, Perrin L, Lacreta FP, Hurbin F, Dubar M Four randomized, placebo-controlled, crossover studies were conducted among 282 healthy subjects to investigate whether an interaction exists between clopidogrel (300-mg loading dose/75-mg/day maintenance dose) and the proton-pump inhibitor (PPI) omeprazole (80√?¬†mg) when they are administered simultaneously (study 1); whether the interaction, if any, can be mitigated by administering clopidogrel and omeprazole 12√?¬†h apart (study 2) or by increasing clopidogrel to 600-mg loading/150-mg/day maintenance dosing (study 3); and whether the interaction applies equally to the PPI pantoprazole (80√?¬†mg) (study 4). Relative to levels after administration of clopidogrel alon...<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>

Impaired hepatic drug and steroid metabolism in congenital adrenal hyperplasia due to P450 oxidoreductase deficiency.

Conclusions Our results provide in vivo evidence for an important role of POR in regulating drug metabolism and detoxification. In patients with ORD, in vivo assessment of drug-metabolizing activities with subsequent tailoring of drug therapy and steroid replacement should be considered. PMID: 20844025 [PubMed - as supplied by publisher] (Source: European Journal of Endocrinology)

Standard triple, bismuth pectin quadruple and sequential therapies for Helicobacter pylori eradication.

CONCLUSION: The sequential therapy has achieved a significantly higher eradication rate, and is a more suitable first-line alternative protocol for anti-H. pylori infection compared with the standard triple and bismuth pectin quadruple therapies. PMID: 20818821 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)

Stress-related mucosal disease: Incidence of bleeding and the role of omeprazole in its prophylaxis.

CONCLUSION: In patients admitted to an internal medicine ward, incidence of upper gastrointestinal bleeding as a complication of stress-related mucosal disease is low. We found that there is no advantage in prophylaxis with omeprazole. PMID: 20816590 [PubMed - in process] (Source: European Journal of Internal Medicine)

Comparison of rosuvastatin and atorvastatin on clopidogrel response and lipidic and inflammatory parameters after coronary stenting for acute coronary syndrome: The prospective, randomized OSCAR study (optimal statin therapy with clopidogrel after coronary revascularisation)

Dual oral antiplatelet therapy is currently the ‚??gold standard‚?Ě therapy in patients undergoing coronary stenting after Non ST Elevation Acute Coronary Syndrome (NSTE ACS) . Several studies have demonstrated a broad variability of biological response to clopidogrel and its clinical relevance . Mechanisms underlying this variability of response remain controversial and multiple factors are involved including metabolic and genetic factors . Clopidogrel is a prodrug, which must be metabolized in the liver to generate an active metabolite and acquire its antiplatelet properties. Accordingly, clopidogrel response has been related to the level of activation of the CYP450 and loss of function allele of CYP2C19 has been associated with lower response to clopidogrel in both healthy volunteers an...

Metformin/omeprazole: Vitamin B12 deficiency in elderly patients: 4 case reports

(Source: Reactions)<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>

Intracellular Calcium Release and Protein Kinase C Activation Stimulate Sonic Hedgehog Gene Expression During Gastric Acid Secretion

Conclusions: Secretagogues that stimulate gastric acid secretion induce Shh gene expression through increased Ca2+i-release and PKC activation. Shh might be the ligand transducing changes in gastric acidity to the regulation of G-cell secretion of gastrin. (Source: Gastroenterology)

Mechanistic characterization of gastric copper transport in rainbow trout

Abstract&nbsp;&nbsp;An in vitro gut-sac technique and 64Cu as a radiotracer were used to characterize gastric copper (Cu) transport. Cu transport was stimulated by low luminal pH (4.0 vs. 7.4), to a greater extent than explained by the increased availability of the free Cu2+ ion. At pH&nbsp;=&nbsp;4.0, uptake kinetics were indicative of a low affinity (K m&nbsp;=&nbsp;525&nbsp;őľmol&nbsp;L‚??1), saturable carrier-mediated component superimposed on a large linear (diffusive and/or convective) component, with about 50% occurring by each pathway at Cu&nbsp;=&nbsp;50&nbsp;őľmol&nbsp;L‚??1. Osmotic gradient experiments showed that solvent drag via fluid transport may play a role in Cu uptake via the stomach, in contrast to the intestine. Also unlike the intestine, neither the Na+ gradient, ...

Role of Cytochrome P450 2C19 Genetic Polymorphisms in the Therapeutic Efficacy of Omeprazole in Iranian Patients with Erosive Reflux Esophagitis.

CONCLUSION: CYP2C19 polymorphism influences the therapeutic efficacy of omeprazole in the treatment of Iranian patients with erosive reflux esophagitis. The clinical response and endoscopic healing of esophagitis are both affected by CYP2C19 genotype condition. PMID: 20804307 [PubMed - in process] (Source: Archives of Iranian Medicine)

Clinically significant CYP2C inhibition by noscapine but not by glucosamine.

Authors: Rosenborg S, Stenberg M, Otto S, Ostervall J, Masquelier M, Yue QY, Bertilsson L, Eliasson E Noscapine and glucosamine reportedly interact with warfarin. We investigated the effects of these drugs on various cytochrome P450 (CYP) activity markers. Twelve healthy subjects were phenotyped at baseline and during separate treatments with noscapine and glucosamine. Whereas glucosamine had no significant effect on CYP activity, noscapine caused marked inhibition of CYP2C9 (4.9-fold increase in urinary losartan/E3174 ratio) and CYP2C19 (3.6-fold increase in the plasma omeprazole/5-hydroxyomeprazole ratio). Noscapine-dependent inhibition of CYP2C9 may explain the interaction with warfarin. PMID: 20668444 [PubMed - indexed for MEDLINE] (Source: Clinical Pharmacology and Therapeutic...

Racemization of the gastrointestinal antisecretory chiral drug esomeprazole magnesium via the pyramidal inversion mechanism: A theoretical study.

Authors: Marom H, Agranat I The pyramidal inversion mechanisms of the 6-methoxy and the 5-methoxy tautomers of (S)-omeprazole were studied, employing ab initio and DFT methods. The conformational space of the model molecule (S)-2-[(3-methyl-2-pyridinyl)methyl]sulfinyl-1H-benzimidazole was calculated, with respect to rotations around single bonds, at the B3LYP/6-311G(d,p) level. All of the resulting conformations were used as starting points for full optimizations of (S)-omeprazole, at B3LYP/6-31G(d), B3LYP/6-311G(d,p), B3LYP/6-311++G(d,p), B3LYP/6-311G(2df,2pd), MP2/6-31G(d), and MP2/6-311G(d,p) levels. Four distinct pathways were found for enantiomerization via the pyramidal inversion mechanism for each of the tautomers of (S)-omeprazole. Each transition state, in which the sulfur, th...<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>

Omeprazole: First report of burning mouth syndrome-like symptoms: case report

(Source: Reactions)

Omeprazole/pantoprazole: Neutropenia: case report

(Source: Reactions)

Optimization and validation of a hydrophilic interaction liquid chromatography-tandem mass spectrometry method for the determination of 13 top-prescribed pharmaceuticals in influent wastewater.

Authors: van Nuijs AL, Tarcomnicu I, Simons W, Bervoets L, Blust R, Jorens PG, Neels H, Covaci A A sensitive hydrophilic interaction liquid chromatography (HILIC)-tandem mass spectrometry method was developed and validated for the analysis of 13 pharmaceuticals (omeprazole, pantoprazole, ranitidine, citalopram, fluoxetine, paroxetine, venlafaxine, tramadol, nebivolol, metoprolol, atenolol, bisoprolol and metformin) in influent wastewater. The analytes were selected from the list of top-sold prescription pharmaceuticals in Belgium. The HILIC separation was optimised to achieve quantification of all analytes in real influent wastewater samples where other compounds, mainly metabolites of some of the pharmaceuticals, were found to interfere even with mass-spectrometric detection in multip...

Comparison Between the Effect of Omeprazole and Rabeprazole on the Antiplatelet Action of Clopidogrel.

Conclusions: Both omeprazole and rabeprazole decreased the antiplatelet effect of clopidogrel. Use of these agents resulted in a similar degree of interference on clopidogrel's action, as measured by ADP-induced platelet aggregation. PMID: 20736505 [PubMed - as supplied by publisher] (Source: Circulation Journal)

GASTROGARD (Omeprazole) Paste [Merial Limited]

Updated Date: Aug 20, 2010 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>

Antineoplastics/cotrimoxazole/omeprazole: Hemifacial paralysis: case report

(Source: Reactions)

Domperidone/omeprazole interaction: Cough in an elderly patient: case report

(Source: Reactions)

Court upholds decision against AstraZeneca's omeprazole

Source: GABI online Area: News On 1 July 2010, the European Court of Justice (ECJ) upheld its decision which found that AstraZeneca had abused its position as market leader for omeprazole by preventing the marketing of generic versions of LosecT. &nbsp; The ECJ confirmed that there was clear evidence of anti-competitive activity, through misuse of the patent and regulatory systems, in order to delay the entry of generic omeprazole, AstraZeneca was fined Euros 60 million which was subsequently reduced by the ECJ to Euros 52.5 million because the EC failed to prove that the deregistration of the marketing authorisations of Losec in Denmark and Norway was capable of having an impact on parallel imports. &nbsp; The European Generic medicines Association welcomed the decision, stating ...

Angioedema after nonsteroidal antiinflammatory drug initiation in a patient stable on an angiotensin-converting-enzyme inhibitor.

Conclusion A 68-year-old African-American man who had been receiving quinapril for 5 years developed angioedema after initiation of naproxen. PMID: 20689124 [PubMed - in process] (Source: American Journal of Health-System Pharmacy : AJHP)

NSAIDs/omeprazole: Kounis syndrome: 4 case reports

(Source: Reactions)<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>

Omeprazole: Anaphylaxis and generalised urticaria: 5 case reports

(Source: Reactions)

Evaluation of the anti-ulcer activity of NR-ANX-C (a polyherbal formulation) in aspirin & pyloric ligature induced gastric ulcers in albino rats.

In this study we evaluated the anti-ulcer efficacy of a polyherbal formulation with potent antioxidant activity in aspirin and pyloric ligature induced gastric ulcers in rats. Methods: The efficacy of the polyherbal formulation NR-ANX-C (composed of the extracts from Withania somnifera, Camellia sinensis, Ocimum sanctum, shilajith and triphala) was evaluated in terms of antioxidant potential as assessed in terms of protection from lipid peroxidation and the antiulcer activity as seen by the area of gastric lesions, gastric juice volume, gastric pH, total acidity and total adherent gastric mucus content. Results: In our study, NR-ANX-C (25 and 50 mg/kg) was more efficacious than ranitidine in reducing ulcer index in both the models. At the highest dose tested (50 mg/kg), NR-ANX-C was compar...

Coxibs Found to Trigger Fewer GI Events in RA

Major Finding: In patients with rheumatoid arthritis or osteoarthritis on long-term NSAID treatment, daily celecoxib produced a 0.9% rate of lower gastrointestinal bleeding events, significantly less than the 3.6% rate in patients treated with diclofenac plus omeprazole. (Source: Rheumatology News)

Clinical dermatology ‚?Ę Concise report: Drug‚?źinduced subacute cutaneous lupus erythematosus associated with omeprazole

(Source: Clinical And Experimental Dermatology)

Celecoxib Triggered Fewer Lower GI Events

Major Finding: In patients with rheumatoid arthritis or osteoarthritis on long-term NSAID treatment, daily celecoxib produced a 0.9% rate of lower gastrointestinal bleeding events, significantly less than the 3.6% rate in patients treated with diclofenac plus omeprazole. (Source: Family Practice News)<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>

Anaphylaxis to omeprazole. Cross-reactivity with the other proton pump inhibitors.

Authors: Rojas P√?¬©rez-Ezquerra P, S√?¬°nchez Morillas L, Laguna Mart√?¬≠nez JJ, Davila Fern√?¬°ndez G, Prado Gomez-Tembleque MD, Santos Alvarez A, Sanz ML PMID: 20678852 [PubMed - as supplied by publisher] (Source: Allergologia et Immunopathologia)

Biochemical and analytical development of the CIME cocktail for drug fate assessment in humans.

We report here the first steps of the development of the innovative CIME cocktail. This cocktail is designed not only for the major cytochrome P450, with caffeine, amodiaquine, tolbutamide, omeprazole, dextromethorphan and midazolam as substrates of CYP1A2, CYP2C8, CYP2C9, CYP2C19, CYP2D6 and CYP3A, respectively, but also phase II enzymes UGT 1A1/6/9 with acetaminophen, P-gp and OATP1B1 with digoxin and rosuvastatin, and renal function with memantine. An assay combining ultra-performance liquid chromatography using a 1.7 microm particle size column with tandem mass spectrometry (UPLC/MS/MS) was set up for the simultaneous quantification of the 20 substrates and metabolites after extraction from human plasma using solid-phase extraction. The method was validated in the spirit of the FDA gui...

Are COX-2 inhibitors preferable to combined NSAID and PPI in countries with moderate health service expenditures?

Conclusion Cost savings may be achieved by using COX-2 inhibitors in patients at high risk of GI adverse effects even in countries with moderate health care service expenditures. Such possibility requires further investigation. (Source: Journal of Evaluation in Clinical Practice)

Helicobacter pylori eradication with a 7-day low-dose triple therapy in hemodialysis patients

Conclusion&nbsp;&nbsp;A 7-day triple therapy with a low-dose OAC regimen was effective and safe for eradication of H. pylori infection in hemodialysis patients. Content Type Journal ArticleCategory Original ArticleDOI 10.1007/s10157-010-0319-7Authors Won-Chul Chang, Konkuk University Hospital Division of Nephrology, Department of Internal Medicine 4-12 Hwayang-dong, Gwangjin-gu Seoul 143-729 KoreaYoung-Il Jo, Konkuk University Hospital Division of Nephrology, Department of Internal Medicine 4-12 Hwayang-dong, Gwangjin-gu Seoul 143-729 KoreaHyung-Seok Park, Konkuk University Hospital Division of Gastroenterology, Department of Internal Medicine Seoul KoreaJoon Jegal, Institute of Biomedical Science and Technology of Konkuk University Seoul KoreaJung-Hwan Park, Konkuk University H...

Optimizing strategies to eradicate Helicobacter pylori

The goal of anti-infective therapy for Helicobacter pylori infection is eradication of the pathogen in order to prevent chronic upper gastrointestinal tract disease and reduce the risk of developing cancer. Standard treatment, as recommended in European and US guidelines, has been associated with progressively decreasing efficacy. In this issue of The Journal, Francavilla et al performed a post hoc analysis of children who had been enrolled in randomized treatment trials for H pylori infection at the University of Bari in Italy. They compared eradication following clarithromycin-based 7-day triple therapy versus 10-day sequential therapy (omeprazole plus amoxicillin for 5 days followed by omeprazole plus clarithromycin plus tinidazole for 5 days) in children who were found to have specific...<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>

[Comment] NSAIDs and risk of lower gastrointestinal bleeding

Non-steroidal anti-inflammatory drugs (NSAIDs) are widely used to treat pain and inflammation in patients with arthritis despite concerns about toxic effects. Alternative treatments are either less effective than are NSAIDs in many patients (paracetamol), or are associated with sedative effects and other concerns (opioids). The risk of NSAID-related bleeding in the upper gastrointestinal tract (stomach or duodenum) is well documented. This risk is reduced with use of a proton-pump inhibitor (PPI) alongside traditional NSAIDs, or with use of a cyclo-oxygenase 2 inhibitor. In a small randomised trial, Chan and colleagues noted that risk of upper gastrointestinal rebleeding did not differ between patients with a recently healed upper gastrointestinal bleed who were taking celecoxib or diclofe...

[Articles] Celecoxib versus omeprazole and diclofenac in patients with osteoarthritis and rheumatoid arthritis (CONDOR): a randomised trial

Cyclo-oxygenase (COX)-2-selective non-steroidal anti-inflammatory drugs (NSAIDs) and non-selective NSAIDs plus a proton-pump inhibitor (PPI) have similar upper gastrointestinal outcomes, but risk of clinical outcomes across the entire gastrointestinal tract might be lower with selective drugs than with non-selective drugs. We aimed to compare risk of gastrointestinal events associated with celecoxib versus diclofenac slow release plus omeprazole. (Source: LANCET)

Autoimmune hepatitis in two psoriasis patients treated with inflixmab

To the Editor: A 37-year-old man was referred to our hospital with a 12-year history of severe plaque-type psoriasis without psoriatic arthritis. He did not drink alcohol. His only medication was omeprazole for a hiatal hernia. Six weeks after the third infusion of infliximab (5 mg/kg at weeks 0, 2, and 6), the patient complained of asthenia, abdominal pain, and arthritis of the wrist. No other drugs or alcohol were taken. Blood tests () showed a strong elevation in transaminase levels, without evidence of cholestatis, but with positive tests for antinuclear antibodies (ANA), double stranded DNA antibodies, and smooth muscle antibodies. Viral serologies were negative. Computed tomography of the liver was normal. No liver biopsy was performed. Spontaneously, the liver function tests (LFTs...

Iatrogenic gastric wall abscess infected with Enterobacter cloacae after biopsy

A 44-year-old man was referred to our hospital because of upper abdominal pain. He was not immunocompromised, nor was he taking any medication to reduce gastric acid secretion. On admission, physical examination results were unremarkable, and a laboratory test evaluation showed no abnormalities; the white blood cell count was normal. An EGD showed a subepithelial protrusion in the duodenal bulb, and a routine biopsy was performed in the greater curvature of the gastric antrum. EUS was done a week later to evaluate the subepithelial protrusion lesion. On entering the stomach, we found a semicircular lump with an opening at its top () at the greater curvature of the gastric antrum. EUS showed only thickening of the gastric antrum (). The lump was lassoed with a polypectomy snare, which, when...

SMC accepts ketoprofen/omeprazole combination preparation (Axorid¬ģ) for the symptomatic treatment of rheumatoid arthritis, ankylosing spondylitis and osteoarthritis

Source: Scottish Medicines Consortium (SMC) Area: Evidence > Drug Specific Reviews The Scottish Medicines Consortium (SMC) has advised that ketoprofen/omeprazole (Axorid¬ģ) is accepted for use within NHS Scotland, for the symptomatic treatment of rheumatoid arthritis, ankylosing spondylitis and osteoarthritis in patients with a previous history or who are at risk of developing NSAID associated gastric ulcers, duodenal ulcers and gastroduodenal erosions in whom continued treatment with ketoprofen is essential. (Source: NeLM - Drug Specific Reviews)<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>

Law Firm Poised to Take Pharmaceutical Companies to Court Over...

New studies show popular &lt;a href="http://www.simmonspharmalaw.com/practices-proton-pump-inhibitor-lawsuits.html"&gt;proton pump inhibitors&lt;/a&gt;, or antacid drugs, like Prilosec can cause serious...Read the full story at http://www.prweb.com/releases/2010/07/prweb4203674.htm (Source: PRWeb: Medical Pharmaceuticals)

Law Firm Poised to Take Pharmaceutical Companies to Court Over Injuries Caused by Antacid Medications

New studies show popular proton pump inhibitors (http://www.simmonspharmalaw.com/practices-proton-pump-inhibitor-lawsuits.html), or antacid drugs, like Prilosec can cause serious fractures. (PRWeb Jul 6, 2010) Read the full story at http://www.prweb.com/releases/2010/07/prweb4203674.htm (Source: PRWeb: Medical Pharmaceuticals)

Comparative study of Nigella Sativa and triple therapy in eradication of Helicobacter Pylori in patients with non-ulcer dyspepsia

Conclusions: N. sativa seeds possess clinically useful anti-H. pylori activity, comparable to triple therapy. Further clinical studies combining N. sativa with antibiotics are suggested. (Source: The Saudi Journal of Gastroenterology)

Marked increase in proton pump inhibitors use in Australia

This study encourages clinical discussion regarding quality use of these medicines. Copyright © 2010 John Wiley & Sons, Ltd. (Source: Pharmacoepidemiology and Drug Safety)

Celecoxib linked to lower rate of gastrointestinal events

The cyclooxygenase (COX)-2 selective nonsteroidal anti-inflammatory drug celecoxib is associated with a lower risk of gastrointestinal adverse events than the NSAID diclofenac plus the proton pump inhibitor omeprazole in patients with osteoarthritis or rheumatoid arthritis, according to a study published online June 17 in The Lancet, reported HealthDay News. (Source: Modern Medicine)<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>

OMEPRAZOLE (Omeprazole And Sodium Bicarbonate) Capsule OMEPRAZOLE (Omeprazole And Sodium Bicarbonate) Capsule [Par Pharmaceutical Inc.]

Updated Date: Jul 7, 2010 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

Proton Pump Inhibitor-Induced Neutropenia: Possible Cross-Reactivity between Omeprazole and Pantoprazole

(Source: Clinical Drug Investigation)

Court upholds antitrust decision on AstraZeneca's Losec

AstraZeneca abused its dominant position by delaying the launch of cheaper generic versions of Losec, its anti-ulcer drug, and should be fined ‚?¨52.5m (¬£42.9m),... (Source: FT.com - Drugs and Healthcare)

Prasco to market Zegerid generic

Prasco Laboratories said Thursday that it is marketing the authorized generic version of Zegerid, an ulcer and esophageal reflux disease treatment. (Source: bizjournals.com Health Care:Health Insurance headlines)

AstraZeneca Loses Bid on Fine

AstraZeneca lost its bid to overturn an antitrust fine imposed on the pharmaceuticals company in 2005 for trying to squeeze out competition for its ulcer capsule Losec. (Source: WSJ.com: Health)

Santarus Announces Launch of Prescription ZEGERID Authorized Generic and Company Restructuring

SAN DIEGO--(BUSINESS WIRE)--Jun 30, 2010 - Santarus, Inc. (NASDAQ: SNTS), a specialty biopharmaceutical company, today announced that pursuant to its distribution and supply agreement with Prasco, LLC, Prasco is commencing shipments of an... (Source: Drugs.com - Pharma News)

AstraZeneca Antitrust Fine Sticks

AstraZeneca lost its bid to overturn an antitrust fine imposed on the pharmaceuticals company in 2005 for trying to squeeze out competition for its ulcer capsule Losec. (Source: WSJ.com: Health)

AstraZeneca loses ulcer drug appeal

EU watchdog's accusations that pharmaceuticals group made misleading statements to patent offices over Losec are upheld, but fine reduced (Source: FT.com - Drugs and Healthcare)

OMEPRAZOLE/SODIUM BICARBONATEpowder, For Suspension OMEPRAZOLE/SODIUM BICARBONATEcapsule [Prasco, Laboratories]

Updated Date: Jul 1, 2010 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

FDA Warns on Fracture Risks With PPIs

The Food and Drug Administration issued a warning to physicians and consumers that proton pump inhibitors may increase the risk of hip, wrist, and spine fractures. The agency said that it is changing the labeling for prescription and over-the-counter versions of proton pump inhibitors (PPIs) to reflect new safety information that is the result of a review of seven epidemiologic studies. Most of the observed risk was in people older than age 50 years and those who took high doses or used the drugs for more than a year. Prescription PPIs include esomeprazole (Nexium), dexlansoprazole (Dexilant), omeprazole (Prilosec, Zegerid), lansoprazole (Prevacid), pantoprazole (Protonix), and rabeprazole (Aciphex). There are OTC versions of Prilosec, Zegerid, and Prevacid. (Source: Ob.Gyn. News)

FDA Warns About Fracture Risks With Use of PPIs

The Food and Drug Administration issued a warning to physicians and consumers that proton pump inhibitors may increase the risk of hip, wrist, and spine fractures. The agency said that it is changing the labeling for prescription and over-the-counter versions of proton pump inhibitors (PPIs) to reflect new safety information that is the result of the FDA's review of seven epidemiologic studies. Most of the observed risk was in people older than age 50 years and those who took high doses or used the drugs for more than a year, said the agency. Prescription PPIs include esomeprazole (Nexium), dexlansoprazole (Dexilant), omeprazole (Prilosec, Zegerid), lansoprazole (Prevacid), pantoprazole (Protonix), and rabeprazole (Aciphex). There are OTC versions of Prilosec, Zegerid, and Prevacid. (Sour...

Santarus Announces Launch Of Prescription ZEGERID Authorized Generic And Company Restructuring

Santarus, Inc., a specialty biopharmaceutical company, today announced that pursuant to its distribution and supply agreement with Prasco, LLC, Prasco is commencing shipments of an authorized generic of prescription ZEGERID (omeprazole/ sodium bicarbonate) Capsules in 20 mg and 40 mg dosage strengths in the U.S. under the Prasco label. (Source: Pharmaceutical Online News)

Should Ranitidine and Omeprazole Be Combined for Peptic Ulcer Disease?

A reader wonders whether combination therapy offers any benefit over single-agent therapy for patients with peptic ulcer disease. Medscape Gastroenterology (Source: Medscape Today Headlines)<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>

Response

Dual endoscopic therapy reduces the rate of recurrent bleeding better than epinephrine injection alone. In a recent publication by us and others, 85% of patients who had a spurting artery or nonbleeding visible vessel were treated with dual endoscopic therapy to eradicate the vessel. The others were treated with epinephrine injection alone, because patients only had blood clots without visible vessels after removal of clots. Among these cases, the tiny stigmata of recent hemorrhage (SRH), usually as small cherry-red spots, were well consolidated by injection of epinephrine. The endoscopic treatment modalities were not different between the 3-day high-dose omeprazole and 7-day low-dose groups. Moreover, the endoscopic therapeutic method was not a significant univariate factor related to reb...

The risk of late-onset nosocomial pneumonia is increased in patients receiving ranitidine and omeprazole

(Source: Reactions)

Omeprazole: Acute hepatitis: case report

(Source: Reactions)

CONDOR trial finds raised GI risk for diclofenac + omeprazole

(Source: Reactions)

Arthritis Relief - Gastrointestinal Damage Less Likely With Celecoxib Than Diclofenac/Omeprazole (CONDOR Study)

Patients receiving a NSAID (non-selective non-steroidal anti-inflammatory drug) as well as a PPI (proton pump inhibitor) - to treat inflammation and pain in arthritis - are more than four times more likely to suffer upper or lower gastrointestinal adverse clinical outcomes compared to those receiving a cyclo-oxygenase (COX)-2 selective NSAID. The findings of the CONDOR study, reported in an Article Online First in the medical journal The Lancet, should encourage review of approaches to reduce risk of NSAID treatment... (Source: Health News from Medical News Today)<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>

Dispatch: Celebrex: Something to Celebrate

A randomized trial published today in The Lancet assesses the risk of adverse gastrointestinal effects & mdash; mainly bleeding & mdash; in osteoarthritis and rheumatoid arthritis patients associated with treatment using celecoxib (Celebrex) in a head-to-head comparison trial versus diclofenac (a commonly used non-steroidal anti-inflammatory drug) plus the stomach-protecting omeprazole (Prilosec). (Source: Health Facts and Fears)

Study finds celecoxib associated with a lower risk of gastrointestinal toxicity (mainly anaemia of presumed occult origin) than omeprazole and diclofenac

Source: No information given Area: News According to results from a 6-month randomised trial, the use of celecoxib for the treatment of osteoarthritis (OA) or rheumatoid arthritis (RA) was associated with a lower incidence of clinically significant gastro-intestinal (GI) events than the combination of diclofenac slow release (SR) and omeprazole. &nbsp; The multicentre CONDOR study enrolled patients with OA or RA who were expected to require regular NSAID treatment for at least six months, and who were negative for H pylori at screening.&nbsp; The trial enrolled those with increased GI risk - those aged ?60 years, or aged 18-59 years with a documented history of gastroduodenal ulceration or gastrointestinal haemorrhage &gt;90 days before screening.&nbsp; There were a number of exclusio...

Celecoxib Linked to Lower Rate of Gastrointestinal Events

The cyclooxygenase-2 selective nonsteroidal anti-inflammatory drug celecoxib is associated with a lower risk of gastrointestinal adverse events than diclofenac plus the proton pump inhibitor omeprazole in patients with osteoarthritis or rheumatoid arthritis, according to a study published online June 17 in The Lancet. (Source: Modern Medicine)

Osteogenic Activity of Locally Applied Small Molecule Drugs in a Rat Femur Defect Model

In this study, we show that local delivery of alendronate, but not lovastatin or omeprazole, led to significant new bone formation at the defect site. Since alendronate impedes osteoclast-development, it is theorized that alendronate treatment results in a net increase in bone formation by preventing osteoclast mediated remodeling of the newly formed bone and upregulating osteoblasts. (Source: Journal of Biomedicine and Biotechnology)

Regulation of basal gastric acid secretion by the glycogen synthase kinase GSK3

Conclusions&nbsp;&nbsp;Basal gastric acid secretion is enhanced by the disruption of PKB/SGK-dependent phosphorylation and the inhibition of GSK3. Thus, the inhibition of GSK3 participates in the signaling of PI3-kinase-dependent downregulation of basal gastric acid secretion. Content Type Journal ArticleCategory Original Article‚??Alimentary TractDOI 10.1007/s00535-010-0260-2Authors Anand Rotte, University of T√ľbingen Department of Physiology Gmelinstr. 5 72076 T√ľbingen GermanyVenkanna Pasham, University of T√ľbingen Department of Physiology Gmelinstr. 5 72076 T√ľbingen GermanyMelanie Eichenm√ľller, University of T√ľbingen Department of Physiology Gmelinstr. 5 72076 T√ľbingen GermanyWenting Yang, University of T√ľbingen Department of Physiology Gmelinstr. 5 72076 T√ľbingen G...<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>

OMEPRAZOLE DELAYED-RELEASE (Omeprazole) Capsule, Delayed Release [State Of Florida DOH Central Pharmacy]

Updated Date: Jun 11, 2010 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

ULCERGARD (Omeprazole) Paste [Merial Limited]

Updated Date: Jun 8, 2010 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

Antioxidant pre-treatment prevents omeprazole-induced toxicity in an in vitro model of infectious gastritis.

Authors: Kohler JE, Blass AL, Liu J, Tai K, Soybel DI Omeprazole is a mainstay of therapy for gastroesophageal reflux disease (GERD) and gastritis, and is increasingly used as an over-the-counter remedy for dyspepsia. Omeprazole acts by selectively oxidizing thiol targets in the gastric proton pump, but it also appears to be toxic to the gastric mucosa. We hypothesized that omeprazole toxicity is due to non-specific oxidation of cell structures other than the proton pump, and tested the efficacy of antioxidants to prevent omeprazole-induced toxicity in isolated rabbit gastric glands. Toxicity was measured by uptake and converstion of calcein-AM, following three hours of exposure to omeprazole and a non-selective thiol-oxidant, monochloramine. Intracellular concentration of Zn(2+) and t...

OMESEC (Omeprazole) Capsule, Delayed Release [Corporacion Infarmasa]

Updated Date: Jun 3, 2010 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

The effect of cytochrome P2C19 and interleukin-1 polymorphisms on H. pylori eradication rate of 1-week triple therapy with omeprazole or rabeprazole, amoxycillin and clarithromycin in Chinese people

What is known and objective: Genetic polymorphism of interleukin (IL)[ndash]1[beta] and IL-1 receptor antagonist (IL-1r[alpha]) are associated with efficacy of acid suppression, whereas cytochrome P (CYP) 2C19 polymorphism influences the metabolism of proton pump inhibitor family. Thus, CYP2C19 and IL-1 polymorphisms may affect the efficacy of H. pylori eradication therapy. We compared the efficacies of omeprazole and rabeprazole on eradication of H. pylori in relation to CYP2C19, IL-1B and IL-1RN genotypes in Chinese people.Methods: Two hundred and forty Chinese with peptic ulcer disease were randomly assigned to the following regimens: amoxicillin and clarithromycin together with omeprazole (OAC) or rabeprazole (RAC). CYP2C19*2 and *3, IL1B-511, IL1B-31, IL1B+ 3954 and intron 2 of the IL...<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>

OMEPRAZOLE (Omeprazole) Tablet, Delayed Release [Dexcel Ltd.]

Updated Date: Jun 1, 2010 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

Prevention by lansoprazole, a proton pump inhibitor, of indomethacin -induced small intestinal ulceration in rats through induction of heme oxygenase-1.

Authors: Yoda Y, Amagase K, Kato S, Tokioka S, Murano M, Kakimoto K, Nishio H, Umegaki E, Takeuchi K, Higuchi K The effect of lansoprazole, a proton pump inhibitor (PPI), on indomethacin-induced small intestinal ulceration was examined in rats, particularly in relation to heme oxygenase (HO)-1. The animals were administered indomethacin (10 mg/kg, p.o.) and killed 24 h later. Lansoprazole (30-100 mg/kg, p.o.) and omeprazole (30-100 mg/kg, p.o.) were given 30 min before the administration of indomethacin, while tin-protoporphyrin IX (SnPP: 30 mg/kg, i.v.), an inhibitor of HO-1, was injected 10 min before indomethacin or lansoprazole. Indomethacin produced hemorrhagic lesions in the small intestine, accompanied with an increase of mucosal invasion of enterobacteria, inducible nitric oxid...

Warning: Common acid-suppressing PPI drugs are over-used and have serious health risks

(NaturalNews) Have heartburn occasionally? Suffer from gastroesophageal reflux disease (GERD) symptoms? Mention your indigestion to a pharmacist and the odds are you'll be directed to proton pump inhibitor (PPI) drugs that are now sold over the counter. Or, if you tell your doctor about your heartburn problems, you'll most likely be given a prescription for an even stronger dose of a PPI. These Big Pharma profit making drugs (which include Prilosec, Nexium, Prevacid, Aciphex and Protonix) are pushed for indigestion because they are supposedly stronger and faster acting than other older acid suppressing and acid neutralizing meds.But there are problems with these widely hyped drugs. According to a series of reports just published in the Archives of Internal Medicine, not only are PPIs being...

FDA Warns of Bone Fracture with Heartburn Drugs

Acid Inhibitors Like Nexium, Prilosec May Cause Fractures When Used for More than a Year (Source: Health News: CBSNews.com)

FDA Warns of Fracture Risk With Popular Heartburn Drugs

Label change to Nexium, Prilosec,other medications should spur patient-doctor discussions, agency says (Source: Pharmacy News - Doctors Lounge)

Proton Pump Inhibitors (PPI): Class Labeling Change

Audience: Family Practice, consumers including Nexium, Dexilant, Prilosec, Zegerid, Prevacid, Protonix, Aciphex, Vimovo, Prilosec OTC, Zegerid OTC, and Prevacid 24HR &nbsp; [Posted 05/25/2010] FDA notified healthcare professionals and patients of... (Source: Drugs.com - FDA MedWatch Alerts)

CYP2C19 activity comparison between Swedes and Koreans: effect of genotype, sex, oral contraceptive use, and smoking

Conclusions&nbsp;&nbsp;We find specific gender-dependent effects of CYP2C19 activity in Koreans, but not in Swedes. Controlling for the effect of genotype and sex, Koreans display lower CYP2C19 activity than Swedes. The genetic, epigenetic or environmental basis for this difference remains to be identified. Content Type Journal ArticleCategory PharmacogeneticsDOI 10.1007/s00228-010-0835-0Authors Margareta Ramsjö, Karolinska University Hospital-Huddinge C1:68 Division of Clinical Pharmacology, Department of Laboratory Medicine at Karolinska Institutet 14186 Stockholm SwedenEleni Aklillu, Karolinska University Hospital-Huddinge C1:68 Division of Clinical Pharmacology, Department of Laboratory Medicine at Karolinska Institutet 14186 Stockholm SwedenLilleba Bohman, Karolinska Uni...

Use of Prilosec: Can This Cause Bone Loss with Implants?

I recently have seen two patients who have functioned well with dental implants for over 10 years with sudden onset bone loss. >>Read More and Comment (Source: Dental Implants Discussed by Experts)<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>

Withdrawal symptoms after gabapentin discontinuation.

Conclusion A patient developed apparent withdrawal symptoms beginning two days after gabapentin therapy was discontinued. The symptoms were unresponsive to treatment with benzodiazepines but completely resolved with the reinitiation of gabapentin therapy. PMID: 20484214 [PubMed - in process] (Source: American Journal of Health-System Pharmacy : AJHP)

Safety of the long-term use of proton pump inhibitors.

Authors: Thomson AB, Sauve MD, Kassam N, Kamitakahara H The proton pump inhibitors (PPIs) as a class are remarkably safe and effective for persons with peptic ulcer disorders. Serious adverse events are extremely rare for PPIs, with case reports of interstitial nephritis with omeprazole, hepatitis with omeprazole and lansoprazole, and disputed visual disturbances with pantoprazole and omeprazole. PPI use is associated with the development of fundic gland polyps (FGP); stopping PPIs is associated with regression of FGP. In the absence of Helicobacter pylori infection, the long-term use of PPIs has not been convincingly proven to cause or be associated with the progression of pre-existing chronic gastritis or gastric atrophy or intestinal metaplasia. Mild/modest hypergastrinemia is a phy...

Nonpigmented fixed drug eruption induced by esomeprazole.

Authors: Morais P, Baudrier T, Mota A, Cunha AP, Cadinha S, Barros AM, Azevedo F A 56-year-old white woman developed a distinctive skin eruption over her mammary, lumbosacral, and pubic areas 2 weeks after the start of esomeprazole therapy for dyspeptic symptoms. Skin biopsy disclosed a spongiotic dermatitis with predominantly lymphocytic dermal infiltrate. Treatment with a tapering dose of corticosteroid and withdrawal of the suspected drug led to a rapid resolution of the eruption without residual dyschromia. Patch testing with esomeprazole 2% in petrolatum was negative at 48 and 72 hours but became positive on day 6. Oral-controlled provocation test induced the reappearance of the lesions over the mammary areas, confirming the putative involvement of this drug. Therefore, the patien...

Kounis syndrome: report of 5 cases.

We report 5 patients attended at our hospital between January 2005 and May 2008 who were diagnosed with unstable angina or acute myocardial infarction-according to analytical parameters, electrocardiographic abnormalities, and/or coronary angiography--in the context of an anaphylactic episode. Age at the time of the episode, age ranged between 50 and 68 years. The results of an allergology study revealed the causal agents to be drugs in 4 cases (nonsteroidal anti-inflammatory drugs and omeprazole) and food in 1 case (kiwi). Coronary disease of a blood vessel was observed in 2 patients. Serious allergic reactions may be the cause of acute coronary syndrome in patients with healthy or altered coronary arteries and no cardiovascular risk factors. PMID: 20461972 [PubMed - in process] (Sour...

Study of cross-reactivity between proton pump inhibitors.

We report 5 cases of immunoglobulin (Ig) E-mediated allergy to omeprazole and document cross-reactivity by skin testing between all the PPIs studied. We also found that the probability of confirming an IgE-mediated mechanism with skin tests decreases with time. Finally, we propose a hypothesis that could explain the different PPI cross-reactivity patterns reported. PMID: 20461971 [PubMed - in process] (Source: Journal of Investigational Allergology and Clinical Immunology)<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>

Improved HPLC method for determination of four PPIs, omeprazole, pantoprazole, lansoprazole and rabeprazole in human plasma.

CONCLUSIONS: The results indicated that this method is a simple, rapid, precise and accurate assay for determination of four PPIs concentrations in human plasma. This validated method is sensitive and reproducible enough to be used in pharmacokinetic studies and also is time- and cost-benefit when selected PPIs are desired to be analyzed. PMID: 20456825 [PubMed - in process] (Source: J Pharm Pharm Sci)

Drugs that reduce stomach acid also increase risk of bone fractures, studies show

The risk goes up about 25% in people using drugs such as Prilosec, Nexium and Protonix. 'For most patients, the adverse effects &#8230; outweigh the benefits,' an editorial in the Archives of Internal Medicine says. The widely used family of acid-reducing drugs that includes Prilosec, Nexium and Protonix increases the risk of bone fractures by about 25% and can more than double the risk of contracting the troublesome bacterium Clostridium difficile , new studies released Monday confirm. (Source: L.A. Times - Health)

Dispatch: Sticks and Stones (and PPIs) May Break Your Bones

A report published in the Archives of Internal Medicine suggests that Proton Pump Inhibitors (PPIs) like AstraZeneca& rsquo;s Nexium and Prilosec & mdash; which treat inflammation of the esophagus, gastroesophageal reflux disease, ulcers and several other conditions by suppressing acid production in the stomach & mdash; can raise the risk of fractures in post-menopausal women and are associated with an increased risk of an uncommon bacterial infection in hospitalized patients. (Source: Health Facts and Fears)

Are Nexium and Prilosec Too Popular?

Series of Studies Raises Concern about Popular Drugs that Treat Acid Reflux and other Stomach Problems (Source: Health News: CBSNews.com)

C. diff Infections, Fractures Linked to Acid Reflux Drugs

PPIs, the popular class of antacids that includes Nexium, Prilosec, Dexilant, Aciphex, and Prevacid, increase risk of C. diff infection and bone fracture, new studies find. (Source: WebMD Health)

Effect of Low-Dose Omeprazole (20 mg Daily) on the Pharmacokinetics of Multiple-Dose Atazanavir With Ritonavir in Healthy Subjects.

This study investigated a clinically effective, low dose of omeprazole (20 mg daily) on atazanavir pharmacokinetics in 56 healthy volunteers given atazanavir/ritonavir 300/100 and 400/100 mg once daily. All atazanavir/ritonavir plus omeprazole combinations resulted in atazanavir area under the concentration-time curve (AUC) and trough concentrations (Cmin) comparable to or exceeding those observed with atazanavir 400 mg without omeprazole. Compared with atazanavir/ritonavir 300/100 mg without omeprazole, atazanavir/ritonavir 300/100 mg plus omeprazole reduced atazanavir AUC and Cmin by 42% and 46%, respectively. Increasing the atazanavir/ritonavir dose to 400/100 mg attenuated the effect of omeprazole, resulting in approximately 30% lower atazanavir Cmin, with all individual Cmin values ex...

POZEN Reports PA65020 Significantly Reduces The Incidence Of Upper GI Damage In Healthy Adults

POZEN Inc. (NASDAQ: POZN) announced that results of a Phase 1 Trial of PA65020, a combination of enteric-coated aspirin (EC-ASA) and immediate-release (IR) omeprazole, show PA65020 significantly reduces the incidence of gastrointestinal (GI) mucosal damage compared to EC-ASA (650 mg twice daily) in healthy adults treated for one month. Patients receiving analgesic doses of EC-ASA were five times more likely to experience significant GI mucosal damage than patients receiving PA65020... (Source: Health News from Medical News Today)

High Efficacy of 14-Day Triple Therapy-Based, Bismuth-Containing Quadruple Therapy for Initial Helicobacter pylori Eradication

Conclusions: Addition bismuth and prolonging treatment duration can overcome H. pylori resistance to clarithromycin and decrease the bacterial load. Fourteen-day triple therapy-based, bismuth-containing quadruple therapy achieved ITT success rate 93% and could be recommended as the first line eradication regimen. (Source: Helicobacter)<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>

Zegerid OTC Provides Greater And Faster Acid Control Than Prevacid 24HR According To Head-To-Head Clinical Study

Merck Consumer Care has announced results of a head-to-head clinical study showing that ZEGERID OTC‚?Ę offers greater and faster acid control than Prevacid¬ģ 24HR. While acid control is an industry standard measure for acid-reducing drugs, greater and faster acid control does not imply greater and faster heartburn symptom relief. The goal of the study was to evaluate the speed and amount of acid reduction when the medications were at full effect, as measured on day seven, which is halfway through the recommended course of treatment... (Source: Health News from Medical News Today)

Zegerid OTC provides greater and faster acid control than Prevacid 24HR according to head-to-head clinical study

(Padilla Speer Beardsley) Merck Consumer Care today announced results of a head-to-head clinical study showing that Zegerid OTC offers greater and faster acid control than Prevacid 24HR. (Source: EurekAlert! - Medicine and Health)

The effect of cytochrome P2C19 and interleukin‚?ź1 polymorphisms on H. pylori eradication rate of 1‚?źweek triple therapy with omeprazole or rabeprazole, amoxycillin and clarithromycin in Chinese people

(Source: Journal of Clinical Pharmacy and Therapeutics)

Original research Treatment with double dose of omeprazole increases -endorphin plasma level in patients with coronary artery disease

Conclusions: Fourteen-day therapy with a double omeprazole dose significantly increases the &#946;-endorphin plasma concentration in patients with CAD. Circulating &#946;-endorphin does not seem to be involved in the mechanism for the &#8220;omeprazole test&#8221; outcome, although an individually different effect on pain threshold cannot be excluded. (Source: Articles of Archives of Medical Science - TERMEDIA publishing house)

Investigation of anti-inflammatory effect of Curcuma longa in Helicobacter pylori-infected patients.

Authors: Koosirirat C, Linpisarn S, Changsom D, Chawansantati K, Wipasa J Helicobacter pylori infection of the lining of stomach induces an array of inflammatory cytokine production leading to gastritis and peptic ulcer disease. The aim of this study was to investigate the effect of curcumin on the production of interleukin (IL)-8, IL-1beta, tumor necrosis factor (TNF)-alpha and cyclooxygenase (COX)-2 in gastric mucosa from H. pylori infected gastritis patients. Patients were randomly assigned to receive either OAM (Omeprazole, Amoxicillin and Metronidazole) treatment or a course of curcumin. Gastric biopsies were collected before and after treatment and were examined for the level of inflammatory cytokines mRNA by semi-quantitative reverse transcription polymerase chain reaction. The ...<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>

Axcan Presents PYLERA(R)'s European Phase III Trial Results At DDW 2010

Axcan Pharma US, Inc., ("Axcan" or the "Company") announced today that the results from its European PYLERA¬ģ Phase III trial comparing the rate of Helicobacter pylori (H. pylori) eradication after OBMT (Omeprazole, Bismuth Subcitrate Potassium, Metronidazole, and Tetracycline) quadruple therapy with a 3-in-1 capsule to H. pylori eradication rate after OAC (Omeprazole, Amoxicillin, and Clarithromycin), has been selected for an oral presentationat the Digestive Disease Week meeting, being held May 1-5, 2010 in New Orleans, LA... (Source: Health News from Medical News Today)

Helicobacter pylori Infection

A 29-year-old man presents with intermittent epigastric discomfort, without weight loss or evidence of gastrointestinal bleeding. He reports no use of aspirin or nonsteroidal antiinflammatory drugs. A serologic test for Helicobacter pylori is positive, and he receives a 10-day course of omeprazole, amoxicillin, and clarithromycin. Six weeks later, he returns with the same symptoms. How should his case be further evaluated and managed? (Source: New England Journal of Medicine)

Patients prescribed clopidogrel plus PPI after MI at increased risk of re-hospitalisation?

Source: Arch Internal Med Area: News A large retrospective observational study indicates an increased risk for re-hospitalisation in patients who take clopidogrel plus a proton-pump inhibitor (PPI) after discharge from hospital following a myocardial infarction (MI) or placement of a coronary stent. The authors interpret this to conclude that PPI use reduces the efficacy of clopidogrel. &nbsp; A number of studies have indicated that patients who take a PPI with clopidogrel are at increased risk of adverse outcomes. There is a plausible mechanism for an interaction between some PPI (e.g. omeprazole) and clopidogrel via one of the cytochrome P450 enzymes necessary for conversion of clopidogrel to its active metabolite (CYP2C19), however the data are conflicting and analysis from randomi...

Influence of CYP2C19 on the relationship between pharmacokinetics and intragastric pH of omeprazole administered by successive intravenous infusions in Chinese healthy volunteers

Conclusions&nbsp;&nbsp;There is a relationship between the pharmacokinetics and pharmacodynamics of omeprazole, with the latter depending in part on the duration of administration as evidenced by a higher AUC or Cmax and intragastric pH resulting from repeated dosing. Content Type Journal ArticleCategory PharmacodynamicsDOI 10.1007/s00228-010-0821-6Authors Yongqing Wang, Nanjing Medical University Research Division of Clinical Pharmacology, The First Affiliated Hospital 300 Guangzhou Road Nanjing 210029 ChinaHongwen Zhang, Nanjing Medical University Research Division of Clinical Pharmacology, The First Affiliated Hospital 300 Guangzhou Road Nanjing 210029 ChinaLing Meng, Nanjing Medical University Research Division of Clinical Pharmacology, The First Affiliated Hospital 300 Gua...

Abstracts from Around the World

There continues to be significant interest in and concern for a negative interaction between proton pump inhibitors (PPIs) and clopidogrel. To become active, clopidogrel is metabolized by the hepatic cytochrome P450 2C19 isoenzyme, and all currently available PPIs are CYP2C19 substrates with some inhibiting its metabolism. This retrospective cohort study examined patients hospitalized for acute myocardial infarction, coronary artery revascularization, or unstable angina pectoris over a 6-year period who were prescribed clopidogrel. They studied the effects of concurrent PPI use on the risk for hospitalization for both gastroduodenal bleeding and serious cardiovascular disease. The dataset was obtained from the Tennessee Medicaid program. Since PPIs may be preferentially prescribed to more ...<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>

Distribution of small intestinal mucosal injuries as a result of NSAID administration

Conclusions The impact of short-term NSAID medication on the small intestine differed according to intestinal site, with most denuded areas identified in the proximal part and all ulcers in the distal part. (Source: European Journal of Clinical Investigation)

What Is The "New Resilience?"

Welcome to "The New Resilience." In this first post, I explain what the title means and how it relates to what I'll be writing about.In my view, our understanding of emotional resilience - and, more broadly, psychological health - doesn't mesh with today's realities. Conventional descriptions of resilience and how to build it don't enable you to handle the challenges and stresses we face in the 21st Century.Let me explain. Resilience is generally defined as the ability to cope successfully with misfortune or traumatic events. Being able to bounce back from adversity and keep on going. What helps you do that include, for example, reviewing your strengths, focusing on positive thoughts and feelings, learning stress management, looking down the road to what you can manage better. And, by gett...

Therapeutic effect of Streptococcus thermophilus CRL 1190-fermented milk on chronic gastritis.

CONCLUSION: This study suggests that fermented milk with S. thermophilus CRL 1190 and/or its EPS could be used in novel functional foods as an alternative natural therapy for chronic gastritis induced by ASA. PMID: 20355240 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)

ZEGERID OTC&trade; Hits Store Shelves; Offers Only Patented Dual-Ingredient Option for 24 Hour Frequent Heartburn Relief without a Prescription

(Source: Merck.com - Product News)

MHRA drug safety update: Clopidogrel and proton pump inhibitor interaction

Source: MHRA Area: Evidence > Medication Safety The April edition of the Drug Safety Update features updated advice regarding the interaction between clopidogrel and proton pump inhibitors. The following advice is provided to healthcare professionals: &nbsp; .&nbsp;Concomitant use of clopidogrel and omeprazole or esomeprazole is to be discouraged unless considered essential .&nbsp;Doctors should check whether patients who are taking clopidogrel are also buying over-the-counter omeprazole and consider whether other gastrointestinal therapies would be more suitable .&nbsp;Pharmacists should check whether patients buying omeprazole are also taking clopidogrel .&nbsp;Consider PPIs other than omeprazole or esomeprazole in patients who are taking clopidogrel. Other gastrointestinal therapy ...<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>

ZEGERID OTC¬? -- Newest OTC Treatment for Frequent Heartburn Now Available

ZEGERID OTC¬? hits the shelves today as another over-the-counter option for treating frequent heartburn. What makes this treatment different from Prilosec OTC and Prevacid 24HR is that it combines more than one ingredient to help treat heartburn. The first ingredient is omeprazole, a proton pump inhibitor, and sodium bicarbonate. The sodium bicarbonate acts as a protection from stomach acid and allows it to be absorbed. According to Dr. Michael Rahmin, gastroenterologist at The Valley Hospital in Ridgewood, New Jersey, "Other OTC PPIs have used an enteric coating to prevent the medicine from being broken down by acid in the stomach prior to absorption. ZEGERID OTC capsules do not need an enteric coating because the sodium bicarbonate offers built-in protection against stomach acid, so the...

OMESEC (Omeprazole) Capsule, Delayed Release [Corporacion Infarmasa]

Updated Date: Mar 31, 2010 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

PRILOSEC (Omeprazole Magnesium) Capsule, Delayed Release PRILOSEC (Omeprazole Magnesium) Granule, Delayed Release [AstraZeneca LP]

Updated Date: Mar 26, 2010 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

Gastrin response to candidate messengers in intact conscious rats monitored by antrum microdialysis.

In this study we created an experimental situation to resemble physiological conditions, using reverse microdialysis to administer regulatory peptides and amines that might affect gastrin secretion. Microdialysis probes were implanted in the submucosa of the antrum of the rat stomach. Three days later, putative messenger compounds were administered via the probe. Their effects on basal (24h fast) and omeprazole-stimulated (400mumol/kg/day, 4days peroral administration) gastrin release were monitored by continuous measurement (3h) of gastrin in the perfusate (radioimmunoassay). Fasted rats (low microdialysate gastrin, 2.1+/-0.1 pmol l(-1)) were used to study stimulation of gastrin release. Omeprazole-treated rats (high microdialysate gastrin, 95.8+/-6.7 pmol l(-1)) were used to study suppre...

Can omeprazole reduce the incidence of hypercalcemia in dialysis patients using calcium containing phosphate binders?

Conclusions: While theoretically advantageous, we found that omeprazole had little clinical benefit in reducing hypercalcemia in a population who are unable to afford non-calcium-based binders; however, further studies may be warranted. PMID: 20349423 [PubMed - as supplied by publisher] (Source: Journal of Nephrology)<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>

Prilosec (Omeprazole) - updated on RxList

Prilosec (Omeprazole) drug description - FDA approved labeling for prescription drugs and medications at RxList (Source: RxList - New and Updated Drug Monographs)

Pharmacokinetics of intrarectal omeprazole in alpacas

Marmulak, T., Stanley, S., Kass, P.H., Wiebe, V., McKemie, D., Pusterla, N. Pharmacokinetics of intrarectal omeprazole in alpacas. J. vet. Pharmacol. Therap. doi: 10.1111/j.1365-2885.2009.00149.x. The purpose of this study was to evaluate the pharmacokinetics of omeprazole in three different vehicles when administered rectally to six alpacas. Alpacas were given single doses of omeprazole (4 mg/kg) in a double-blinded, randomized cross-over design with a 1 week washout period. Omeprazole formulations consisted of (1) Treatment A: omeprazole paste mixed in surgical lubricant (2) Treatment B: omeprazole capsule contents in 8.4% sodium bicarbonate and (3) Treatment C: omeprazole capsule contents in surgical lubricant and 8.4% sodium bicarbonate solution. Plasma samples were drawn at 0, 5, 10, ...

CHMP updates warning over concomitant use of clopidogrel and PPIs

Source: EMEA Area: News The EMEA has recommended an amendment to the existing warning over the concurrent use of clopidogrel and proton-pump inhibitors (PPIs).&nbsp; This follows an analysis of data that has become available since the original recommendation in May 2009 (see link below). &nbsp; Although some of the new studies raise questions regarding the clinical relevance of interactions between PPIs as a class and clopidogrel, two studies have confirmed that omeprazole can reduce the levels of the active form of clopidogrel in the blood and reduce its antiplatelet effects.&nbsp; These support the conclusion that there is an interaction between clopidogrel and omeprazole and esomeprazole. &nbsp; Taking all of the currently available data into account, the CHMP and its Pharmacov...

Cadmium inhibits acid secretion in stimulated frog gastric mucosa.

Authors: Gerbino A, Debellis L, Caroppo R, Curci S, Colella M Cadmium, a toxic environmental pollutant, affects the function of different organs such as lungs, liver and kidney. Less is known about its toxic effects on the gastric mucosa. The aim of this study was to investigate the mechanisms by which cadmium impacts on the physiology of gastric mucosa. To this end, intact amphibian mucosae were mounted in Ussing chambers and the rate of acid secretion, short circuit current (I(sc)), transepithelial potential (V(t)) and resistance (R(t)) were recorded in the continuous presence of cadmium. Addition of cadmium (20microM to 1mM) on the serosal but not luminal side of the mucosae resulted in inhibition of acid secretion and increase in NPPB-sensitive, chloride-dependent short circuit cur...

Metabolism of Carbosulfan II. Human Interindividual Variability in its In Vitro Hepatic Biotransformation and the Identification of the Cytochrome P450 Isoforms Involved.

This study aims to characterize interindividual variability and individual CYP enzymes involved in the in vitro metabolism of the carbamate insecticide carbosulfan. Microsomes from ten human livers (HLM) were used to characterize the interindividual variability in carbosulfan activation. Altogether eight phase I metabolites were analyzed by LC-MS. The primary metabolic pathways were detoxification by the initial oxidation of sulfur to carbosulfan sulfinamide ('sulphur oxidation pathway') and activation via cleavage of the nitrogen sulfur bond (N-S) to give carbofuran and dibutylamine ('carbofuran pathway'). Differences between maximum and minimum carbosulfan activation values with HLM indicated nearly 5.9-, 7.0, and 6.6-fold variability in the k(m), V(max) and Cl(int) values, respectively....<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>

Toxic tacrolimus blood levels with rifampin administration in a renal transplant recipient.

Conclusions: We conclude that chronic diarrhea may cause toxic tacrolimus blood levels even in presence of rifampin, this would be due to its significant cytochrome P450-3A4 and P-glycoprotein enzyme inhibitory effect.&lt;br /&gt; PMID: 20305320 [PubMed - in process] (Source: Annals of Transplantation)

Meta-analysis: can Helicobacter pylori eradication treatment reduce the risk for gastric cancer?

Source: DARE Area: Evidence > Disease Focused Reviews CRD Summary: This generally well-conducted review concluded that Helicobacter pylori eradication treatment appeared to reduce gastric cancer risk, but the generalisability of the findings may be limited. Also, they are based on evidence of variable reliability. These conclusions are an accurate reflection the results of the review and appear to be reliable. [Eradication treatment regimes included differing combinations and doses of the following agents: amoxicillin, metronidazole, bismuth subsalicylate, omeprazole, lansoprazole, clarithromycin. ] CRD Commentary: The review question was clear and was supported by specific inclusion criteria. The search included a number of relevant databases and other sources. This, along with the l...

OMEPRAZOLE MAGNESIUMcapsule, Delayed Release [Dr. Reddy'S Laboratories Limited]

Updated Date: Mar 16, 2010 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

Sex and CYP3A5 genotype influence total CYP3A activity: high CYP3A activity and a unique distribution of CYP3A5 variant alleles in Ethiopians

Authors: E Gebeyehu, E Engidawork, A Bijnsdorp, A Aminy, U Diczfalusy & E Aklillu (Source: The Pharmacogenomics Journal)

Outcomes with concurrent use of clopidogrel and proton-pump inhibitors: a cohort study.

Conclusion: In patients with serious coronary heart disease treated with clopidogrel, concurrent PPI use was associated with reduced incidence of hospitalizations for gastroduodenal bleeding. The corresponding point estimate for serious cardiovascular disease was not increased; however, the 95% CI included a clinically important increased risk. Primary Funding Source: Agency for Healthcare Research and Quality and National Heart, Lung, and Blood Institute. PMID: 20231564 [PubMed - in process] (Source: Annals of Internal Medicine)<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>

Short-duration furazolidone therapy in combination with amoxicillin, bismuth subcitrate, and omeprazole for eradication of

Conclusion: One week of furazolidone in combination with 2 weeks of amoxicillin, omeprazole, and bismuth subcitrate is a safe and cost-effective regimen for the eradication of H pylori. Adding metronidazole to the above regimen does not increase the eradication rate. (Source: The Saudi Journal of Gastroenterology)

SMC does not recommend ketoprofen/omeprazole (Axorid¬ģ) for rheumatoid arthritis, ankylosing spondylitis and osteoarthritis

Source: Scottish Medicines Consortium (SMC) Area: Evidence > Drug Specific Reviews The Scottish Medicines Consortium (SMC) does not recommend ketoprofen/omeprazole (Axorid¬ģ) for use within NHS Scotland for the symptomatic treatment of rheumatoid arthritis, ankylosing spondylitis and osteoarthritis in patients with a previous history or who are at risk of developing NSAID associated gastric ulcers, duodenal ulcers and gastroduodenal erosions in whom continued treatment with ketoprofen is essential. &nbsp; The drug advice notes that the manufacturer did not present a sufficiently robust economic analysis to gain acceptance by the SMC.&nbsp; The licence holder has indicated their intention to resubmit.&nbsp; Please see the link below for details. (Source: NeLM - Drug Specific Reviews)

Omeprazole induces gastric transmucosal permeability to the peptide bradykinin.

CONCLUSION: The omeprazole-induced gastric leak allows for transmucosal permeability to charged molecules as well as non-electrolytes. This induced leak will allow certain peptides to permeate. PMID: 20205280 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)

A Randomized Controlled Trial: Efficacy and Safety of Azithromycin, Ofloxacin, Bismuth, and Omeprazole Compared With Amoxicillin, Clarithromycin, Bismuth, and Omeprazole as Second-Line Therapy in Patients With Helicobacter&nbsp;pylori Infection

Conclusion: Two weeks of treatment with ofloxacin, azithromycin, omeprazole, and bismuth is an effective and safe regimen for H. pylori eradication as second-line therapy. (Source: Helicobacter)

A Case Series of Proton Pump Inhibitor‚??Induced Hypomagnesemia

Proton pump inhibitor (PPI)-induced hypomagnesemia has been recognized since 2006. Our aim was to further characterize the clinical consequences and possible mechanisms of this electrolyte disorder using 4 cases. Two men (aged 63 and 81 years) and 2 women (aged 73 and 62 years) had been using a PPI (esomeprazole, pantoprazole, omeprazole, and rabeprazole, 20-40 mg) for 1-13 years. They developed severe hypomagnesemia (magnesium, 0.30 ¬Ī 0.28 mEq/L; reference, 1.40-2.10 mEq/L) with hypocalcemia (calcium, 6.4 ¬Ī 1.8 mg/dL), relative hypoparathyroidism (parathyroid hormone, 43 ¬Ī 6 pg/mL), and extremely low urinary calcium and magnesium excretion. One patient was admitted with postanoxic encephalopathy after a collapse likely caused by arrhythmia. The others had electrocardiogram abnormalitie...<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>

Should Omeprazole or Clopidogrel Be Substituted When Given Concomitantly?

An "Ask the Expert" panelist answers readers' questions about the interaction between clopidogrel and PPIs. Medscape Pharmacists (Source: Medscape Today Headlines)

PRILOSEC (Omeprazole Magnesium) Capsule [STAT RX USA LLC]

Updated Date: Mar 1, 2010 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

Post operative pain: analgesic combinations and adverse effects

The objectives of this study were to analyze the prevalence of medicine combination and interaction and to verify the association of this with the observed adverse effects. It was a descriptive, exploratory and retrospective study. The sample was composed by 260 patient data submitted to hemorrhoidectomy, up to 60 years old, healthy. Results showed that the mostly used medicine associations were dipyrone sodium and omeprazole (33.7%), dypirone sodium and ketoprofen (23.6%) and cetoprofen and lactulose (22.8%). It was observed that ketoprofen + omeprazole (p=0.001) and ketoprofen + lactulose (p=0.03) were significantly associated with bleeding. It was observed that, excepting ketoprofen, the other medicine association identified in the study showed to be safe to be used in the post surgical...

GOOD SENSE OMEPRAZOLE (Omeprazole) Tablet, Delayed Release [L Perrigo Company]

Updated Date: Feb 26, 2010 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

Clinical and cost impact of intravenous proton pump inhibitor use in non-ICU patients.

CONCLUSION: This study highlights the over-utilization of IV PPIs in non-intensive care unit patients. Restriction of IV PPI use for justified indications and route of administration is recommended. PMID: 20180237 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>

TOPCARE OMEPRAZOLE (Omeprazole) Tablet, Delayed Release [Topco Associates LLC]

Updated Date: Feb 25, 2010 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

BERKLEY AND JENSEN OMEPRAZOLE (Omeprazole) Tablet, Delayed Release [BJWC]

Updated Date: Feb 25, 2010 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

Omeprazole preferentially inhibits the metabolism of (+)-(S)-citalopram in healthy volunteers

CONCLUSIONS The administration of multiple doses of omeprazole preferentially inhibited (+)-(S)-CITA metabolism in healthy volunteers. Although omeprazole increased plasma concentrations of (+)-(S)-CITA by approximately 120%, it is difficult to evaluate the clinical outcome because the range of plasma CITA concentrations related to maximum efficacy and minimum risk of adverse effects has not been established. (Source: British Journal of Clinical Pharmacology)

Omeprazole: Hyponatraemia in an elderly patient: case report

(Source: Reactions)

WITHDRAWN: Medical treatments for the maintenance therapy of reflux oesophagitis and endoscopic negative reflux disease.

CONCLUSIONS: The findings in this review support the long-term treatment of oesophagitis to prevent relapse, both endoscopically and symptomatically. Healing doses of PPIs are more effective than all other therapies, although there is an increase in overall adverse effects compared to placebo, and headache occurrence compared to H2RAs. H2RAs prevent relapse more effectively than placebo, demonstrating a role for PPI-intolerant patients. Prokinetics and sucralfate both show benefit over placebo, but the former is no longer licenced. There is only limited data for ENRD. PMID: 20166065 [PubMed - in process] (Source: Cochrane Database of Systematic Reviews)<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>

Clinical trial: clarithromycin vs. levofloxacin in first-line triple and sequential regimens for Helicobacter pylori eradication

Conclusions Levofloxacin-based and sequential therapy are superior to standard triple scheme as first-line regimens in a setting with high clarithromycin resistance. However, all of these therapies still have a 20% failure rate. (Source: Alimentary Pharmacology and Therapeutics)

Efficacy of Standard Triple Therapy in the Treatment of Helicobacter pylori Infection: Experience from Kuwait

Conclusion&nbsp;&nbsp;The efficacy of the current standard triple therapy for H. pylori eradication in our community is suboptimal. Confirmation for H. pylori eradication with noninvasive tests is recommended, especially in high-risk patients. New antimicrobial regimens for H. pylori eradication are considered necessary. Content Type Journal ArticleCategory Original ArticleDOI 10.1007/s10620-010-1139-zAuthors Waleed M. Alazmi, Amiri Hospital Thunayan Alghanim Center of Gastroenterology Kuwait City KuwaitWaleed Buhaimed, Amiri Hospital Thunayan Alghanim Center of Gastroenterology Kuwait City KuwaitKhalid Al-Mekhaizeem, Amiri Hospital Thunayan Alghanim Center of Gastroenterology Kuwait City KuwaitIqbal Siddique, Amiri Hospital Thunayan Alghanim Center of Gastroenterology Kuwait Ci...

Prophylactic Role of a Herbomineral Drug "Thamira Parpam" Against Cysteamine-Induced Oxidative Stress in Liver and Duodenum of Rats.

Prophylactic Role of a Herbomineral Drug "Thamira Parpam" Against Cysteamine-Induced Oxidative Stress in Liver and Duodenum of Rats. Biol Trace Elem Res. 2010 Feb 18; Authors: Parameswari RP, Vasanthkumar M, Gayathri V, Manikandamathavan VM, Ramakrishnan G, Sangeetha MK, Vijayakumar V, Raghavendran HB, Chamundeeswari D, Vasanthi HR Copper is known as Gunma Kaalan in Siddha literature, which means that the drug is effective for healing ulcers. The herbomineral drug "Thamira parpam" is prepared by calcining the purified copper foils with rock salt, lime juice, bracteated birth wort juice, and Alangium root decoction according to Siddha medicine. Our study investigated the possible role of Thamira parpam (TP) in the management of cysteamine-induced duodenal ulcers. Cysteamine (400...

TSU-16, (Z)-3-[(2,4-dimethylpyrrol-5-yl)methylidenyl]-2-indolinone, is a potent activator of aryl hydrocarbon receptor and increases CYP1A1 and CYP1A2 expression in human hepatocytes.

In conclusion, our present results suggest that TSU-16 binds to and activates AhR to enhance the expression of both human CYP1A1 and CYP1A2. Because TSU-16 is metabolized mainly by CYP1A2, its increased clearance after repeated dosing may be attributed to the enhanced expression of hepatic CYP1A2. PMID: 20171196 [PubMed - as supplied by publisher] (Source: Chemico-Biological Interactions)

Patchy alopecia following chemotherapy

A 57-year-old white female presented with small, scattered patches of alopecia. She had a history of metastatic ductal breast cancer, and 2 months before her visit had finished three cycles of adriamycin and cyclophosphamide followed by three cycles of docetaxol and cyclophosphamide. Her current medications included anastrazole and omeprazole. She denied any areas of alopecia before treatment, and she lost all of her hair during chemotherapy. Following chemotherapy, she noticed that some areas of her scalp remained bald. She denied pruritus, pain, and flaking. She had not attempted to treat the condition. She denied any personal or family history of autoimmune disorders. Her review of systems was negative. A physical examination revealed many scattered, 1- to 2-cm, white, atrophic patches ...<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>

Lansoprazole/omeprazole/pantoprazole: Severe hypomagnesaemia, and hypocalcaemia and hypokalaemia: case report

(Source: Reactions)

Correction of reimbursement price for omeprazole 20mg capsules for February

Source: PSNC (Pharmaceutical Services Negotiating Committee) Area: News The Department of Health have agreed that the Drug Tariff Part VIII reimbursement price for omeprazole 20mg capsules for February 2010 is £2.99, not £1.76 as printed in the February edition of the Drug Tariff. This reimbursement price will be applied to all prescriptions submitted for February 2010. (Source: NeLM - News)

A Phenotype-Genotype Approach to Predicting CYP450 and P-Glycoprotein Drug Interactions With the Mixed Inhibitor/Inducer Tipranavir/Ritonavir.

Authors: Dumond JB, Vourvahis M, Rezk NL, Patterson KB, Tien HC, White N, Jennings SH, Choi SO, Li J, Wagner MJ, La-Beck NM, Drulak M, Sabo JP, Castles MA, Macgregor TR, Kashuba AD The effects of tipranavir/ritonavir (TPV/r) on hepatic and intestinal P-glycoprotein (P-gp) and cytochrome P450 (CYP) enzyme activity were evaluated in 23 volunteers. The subjects received oral (p.o.) caffeine, warfarin + vitamin K, omeprazole, dextromethorphan, and midazolam and digoxin (p.o. and intravenous (i.v.)) at baseline, during the first three doses of TPV/r (500 mg/200 mg b.i.d.), and at steady state. Plasma area under the curve (AUC)(0-infinity) and urinary metabolite ratios were used for quantification of protein activities. A single dose of TPV/r had no effect on the activity of CYP1A2 and CYP2C...

Validated assay for studying activity profiles of human liver UGTs after drug exposure: inhibition and induction studies.

Authors: Donato MT, Montero S, Castell JV, G&#xF3;mez-Lech&#xF3;n MJ, Lahoz A UDP-glucuronsyltransferases (UGTs) are a family of conjugating enzymes that participate in the metabolism of many drugs. The study of potential drug-drug interactions involving UGTs has been largely hindered by the limited availability of selective functional assays for individual UGT enzymes. We propose a sensitive and reproducible procedure for the activity measurements of four major human hepatic UGT forms. The assays are based on analysis and quantification by high-performance liquid chromatography-tandem mass spectrometry of glucuronides formed from selective probe substrates, namely, beta-estradiol (UGT1A1, 3-glucuronide), 1-naphthol (UGT1A6), propofol (UGT1A9), and naloxone (UGT2B7). The analytical met...

Zegerid (Omeprazole, Sodium Bicarbonate) - updated on RxList

Zegerid (Omeprazole, Sodium Bicarbonate) drug description - FDA approved labeling for prescription drugs and medications at RxList (Source: RxList - New and Updated Drug Monographs)<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>

Omeprazole-Mg 20.6&nbsp;mg is superior to lansoprazole 15&nbsp;mg for control of gastric acid: a comparison of over-the-counter doses of proton pump inhibitors

Conclusion Omeprazole-Mg 20.6 mg provided a statistically significantly (P < 0.0001) greater acid control than lansoprazole 15 mg. (Source: Alimentary Pharmacology and Therapeutics)

Adverse Effects of Long-Term Proton Pump Inhibitor Use: A Review for the Otolaryngologist

Conclusion: Given these epidemiological patterns, we recommend that the clinician be aware of these possible unintended consequences. In addition, we recommend consideration of dual-energy X-ray absorptiometry (DEXA) bone density scans in at-risk patients who have not been previously tested. We recommend consideration of vitamin B12 and iron levels in selected patients who are at high risk. We also recommend close communication with our cardiology colleagues, as we attempt to ascertain the relationship between clopidogrel and PPI use. We recommend caution in the use of omeprazole in patients undergoing active treatment for ACS. Finally, we recommend consideration of Helicobacter pylori or serum gastrin level testing in patients with known risk factors for gastric carcinoma. (Source: Journa...

The Role of L: -arginine in Inclusion Complexes of Omeprazole with Cyclodextrins.

In this study, we investigate how the effect of L: -arginine (ARG) and cyclodextrins upon omeprazole (OME) stability and solubility. The effect of the presence of ARG on the apparent stability constants (K(1:1)) of the inclusion complexes formed between OME and each cyclodextrin, beta-cyclodextrin (betaCD), and methyl-beta-cyclodextrin (MbetaCD) is studied by phase solubility diagrams and nuclear magnetic resonance (NMR) spectroscopy. The interaction of OME with those cyclodextrins, in the presence of ARG, is characterized using NMR spectroscopy and molecular dynamics simulations. ARG significantly increases the drug solubility and complex stability, in comparison to inclusion complexes formed in its absence. The effect is more pronounced for the OME:betaCD complex. ARG also contributes to...

[Variability in the measurement of the pharmaceutical prescription quality by autonomous communities.]

CONCLUSION: Each regional health service has developed its own set of drug prescription quality indicators. Consequently, there is great variability between regions in the assessment of the quality of drug prescription. Common indicators are needed in order to establish a benchmarking process between regional health services. PMID: 20138406 [PubMed - as supplied by publisher] (Source: Atencion Primaria)

Omeprazole and clopidogrel: Should clinicians be worried?

The US Food and Drug Administration has issued a warning that omeprazole (Prilosec) reduces the antiplatelet activity of clopidogrel (Plavix) by about 50%. However, the warning is based largely on ex vivo data. Preliminary results from a randomized clinical trial revealed no effect on cardiovascular outcomes when omeprazole was given with clopidogrel. We recommend that physicians continue to prescribe a proton pump inhibitor for patients receiving dual antiplatelet therapy who are at risk of gastrointestinal bleeding or have an indication for use of a proton pump inhibitor. (Source: Cleveland Clinic Journal of Medicine)<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>

Effectiveness and Safety of Proton Pump Inhibitors in Infantile Gastroesophageal Reflux Disease (March).

CONCLUSIONS: Clinical trials reveal that PPI therapy is not an effective treatment for common infant GERD-associated symptoms. Evidence supporting safety of PPI use in infants is conflicting, and more large-scale, randomized, placebo-controlled trials are necessary to better establish the role of PPIs in infant GERD. PMID: 20124466 [PubMed - as supplied by publisher] (Source: The Annals of Pharmacotherapy)

High Risk Ulcer Bleeding: When Is Second-Look Endoscopy Recommended?

A 78-year-old gentleman with background history of is-chemic heart disease and diabetes mellitus, presents with passage of tarry stool for 2 days. He is taking regular aspirin 80 mg daily. Upon admission he has blood pressure of 90/60 and pulse rate of 120 beats per minute. An emergency upper endoscopy performed at 3 am by the on-call gastrointestinal fellow showed a visible vessel beneath a 2 cm gastric ulcer (A). There was 500 ml of fresh blood in the fundus obscuring the endoscopic view. Endoscopic injection of epinephrine followed by application of hemoclips achieved hemostasis (B and C). He is given intravenous omeprazole infusion 80 mg bolus followed by 8 mg per hour for 72 hours. A second endoscopy was scheduled and performed on the next day which showed persistent stigmata of visib...

Omeprazole-induced acute interstitial nephritis is not related to CYP2C19 genotype or CYP2C19 phenotype

CONCLUSIONS There was discordance between CYP2C19 genotype and phenotype. However, up to 45% of healthy elderly subjects have a poor metabolizer phenotype. Thus neither CYP2C19 poor metabolizer genotype nor phenotype is a risk factor for OIAIN. (Source: British Journal of Clinical Pharmacology)

Potentially inappropriate prescribing and cost outcomes for older people: a national population study

CONCLUSIONS The findings identify a high prevalence of PIP in Ireland with significant cost consequences. (Source: British Journal of Clinical Pharmacology)

Efficacy of Omeprazole versus High-Dose Famotidine for Prevention of Exercise-Induced Gastritis in Racing Alaskan Sled Dogs

Omeprazole and famotidine both reduce severity of exercise-induced gastritis, but administering famotidine is easier than administering omeprazole during racing competition. Famotidine is more efficacious than no treatment in reducing severity of exercise-induced gastritis; and high-dose famotidine is more efficacious than omeprazole in reducing severity of exercise-induced gastritis. Experiment 1: Randomized placebo-controlled study, 36 sled dogs (3[ndash]8 years); Experiment 2: Randomized positive-control study, 52 sled dogs (2[ndash]8 years). Experiment 1: Equal numbers of dogs randomly assigned to famotidine (20 mg q24h) or no treatment groups. Gastroscopy was performed 24 hours after the dogs ran 330 miles. Mucosal appearance was blindly scored by previously described scoring system. ...<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>

The potential therapeutic effect of melatonin in gastro-esophageal reflux disease

Conclusion: The present study showed that oral melatonin is a promising therapeutic agent for the treatment of GERD. It is an effective line of treatment in relieving epigastric pain and heartburn. However, further studies are required to confirm the efficacy and long-term safety of melatonin before being recommended for routine clinical use.Trial Registration QA13NCT00915616 (Source: BMC Gastroenterology)

Gastrin release: Antrum microdialysis reveals a complex neural control.

Authors: Ericsson P, H&#xE5;kanson R, Rehfeld JF, Norl&#xE9;n P We used microdialysis to monitor local gastrin release in response to food, acid blockade and acute vagal excitation. For the first time, gastrin release has been monitored continuously in intact conscious rats in a physiologically relevant experimental setting in a fashion that minimizes confounding systemic effects. Microdialysis probes were placed in the submucosa on either side of the antrum, 3days before the experiments. The concentration of gastrin in the antral submucosal compartment was 5-10 times higher than in serum regardless of the prandial state. The rats were conscious during microdialysis except when subjected to electrical vagal stimulation. Acid blockade (omeprazole treatment of freely fed rats for 4days),...

Plavix-Prilosec interaction warning

FDA has announced that concomitant use of omeprazole (Prilosec, AstraZeneca, and Prilosec OTC, Procter &amp; Gamble) and clopidogrel (Plavix, Sanofi Aventis/Bristol-Myers Squibb) can reduce the anti-clotting effectiveness of clopidogrel. (Source: Drug Topics - Top News)

Short-duration furazolidone therapy in combination with amoxicillin, bismuth subcitrate, and omeprazole for eradication of &lt;i&gt;Helicobacter pylori&lt;/i&gt;

Conclusion:&#x0026;lt;/b&#x0026;gt; One week of furazolidone in combination with 2 weeks of amoxicillin, omeprazole, and bismuth subcitrate is a safe and cost-effective regimen for the eradication of &#x0026;lt;i&#x0026;gt;H pylori&#x0026;lt;/i&#x0026;gt;. Adding metronidazole to the above regimen does not increase the eradication rate. (Source: The Saudi Journal of Gastroenterology)

Can a Short Course of Prophylactic Low-dose Proton Pump Inhibitor Therapy Prevent Stomal Ulceration After Laparoscopic Roux-en-Y Gastric Bypass?

Conclusion&nbsp;&nbsp;Development of stomal ulceration in patients tested positive for H. pylori prior to LRYGBP can be prevented by prophylactic low-dose PPI therapy following surgery. Content Type Journal ArticleCategory OtherDOI 10.1007/s11695-009-0062-xAuthors Mathieu Andr√© D‚??Hondt, Groeninge Hospital Houtmarkt 33 8500 Kortrijk BelgiumHans Pottel, Katholieke Universiteit Leuven Interdisciplinary Research Center Kortrijk BelgiumDirk Devriendt, Groeninge Hospital Houtmarkt 33 8500 Kortrijk BelgiumFrank Van Rooy, Groeninge Hospital Houtmarkt 33 8500 Kortrijk BelgiumFranky Vansteenkiste, Groeninge Hospital Houtmarkt 33 8500 Kortrijk Belgium Journal Obesity SurgeryOnline ISSN 1708-0428Print ISSN 0960-8923 (Source: Obesity Surgery)

AstraZeneca, Teva settle patent litigation over Nexium and Prilosec

Pharmaceutical Industries Ltd. agreed Thursday to settle patent litigation regarding Teva‚??s U.S. generic versions of AstraZeneca‚??s Prilosec and Nexium products for heartburn and acid reflux. (TEVA) (AZN) (Source: bizjournals.com Health Care:Health Insurance headlines)

Teva Announces Settlement Agreements with AstraZeneca Regarding Generic Prilosec(R) and Nexium(R)

JERUSALEM--(HSMN NewsFeed)--Teva Pharmaceutical Industries Ltd. (Nasdaq: TEVA ) announced today that it has entered into two definitive agreements with AstraZeneca to settle patent litigation regarding Teva¬?s U.S. generic versions of AstraZeneca¬?s Prilosec... Biopharmaceuticals, Generics, LitigationTeva Pharmaceutical, AstraZeneca, Prilosec, omeprazole, Nexium, esomeprazole (Source: HSMN NewsFeed)

omeprazole, omeprazole/sodium bicarbonate, Prilosec, Zegerid

Title: omeprazole, omeprazole/sodium bicarbonate, Prilosec, ZegeridCategory: MedicationsCreated: 12/31/1997Last Editorial Review: 1/7/2010 (Source: MedicineNet Allergies General)

Axorid 100 mg/20 mg and 200mg/20mg modified-release capsules (ketoprofen/omeprazole) - New product

Source: eMC (electronic Medicines Compendium) Area: Other Library Updates > SPC Changes Each modified-release capsule contains ketoprofen 100 mg or 200 mg and omeprazole 20 mg. They are licensed for symptomatic treatment of rheumatoid arthritis, ankylosing spondylitis and osteoarthritis in patients with a previous history or who are at risk of developing NSAID associated gastric ulcers, duodenal ulcers and gastroduodenal erosions in whom continued treatment with ketoprofen is essential. The daily dose is 100 mg/20 mg to 200 mg/20 mg depending of the severity of symptoms. (Source: NeLM - Pain control)

[Correspondence] Combination therapy with clopidogrel and proton-pump inhibitors ‚?? Authors' reply

James Muldowney and Cassandra Benge ask whether a moderately strong inhibitor of the CYP2C19 enzyme confers an excess in cardiovascular risk that is similar to what has been seen for clopidogrel-treated patients with a genetic polymorphism of the CYP2C19 allele. We saw a modest attenuation of the in-vitro antiplatelet effects of clopidogrel in the presence of a proton-pump inhibitor (PPI); however, the use of a PPI was not associated with an increased risk of cardiovascular events in the TRITON-TIMI 38 trial. These findings were consistent for PPIs that are stronger inhibitors of CYP2C19, such as omeprazole, and among patients who had diminished CYP2C19 activity at baseline owing to a genetic polymorphism. The association between PPI type and genotype was not examined because of limited sa...

FDA: Avoid Clopidogrel With Omeprazole

Elizabeth Mechcatie is a senior writer with Elsevier Global Medical News. The Food and Drug Administration is recommending that patients not take clopidogrel and omeprazole together on the basis of new data recently submitted to the agency indicating that the effectiveness of the antiplatelet drug is reduced when taken with the proton pump inhibitor. (Source: Caring for the Ages)

FDA: Avoid Combining Clopidogrel and Omeprazole

The Food and Drug Administration recommends that patients not take clopidogrel and omeprazole together on the basis of new data submitted to the agency indicating that the effectiveness of the antiplatelet drug is reduced when taken with the proton pump inhibitor, according to a public health advisory issued by the agency. (Source: Clinical Endocrinology News)<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>

Irreversible encephalopathy after treatment with high-dose intravenous metronidazole.

Conclusion: This patient had a fatal encephalopathy, probably associated with long-standing exposure to high plasma concentration peaks of metronidazole, due to a once-daily dose of 1500 mg IV over several weeks. PMID: 20171413 [PubMed - as supplied by publisher] (Source: Clinical Therapeutics)

Drug utilisation among older inpatients in a teaching hospital in Western Nepal.

Conclusion: The use of a high number of drugs, and of parenteral drugs and intravenous fluids, is a common problem. The prescription of generic drugs is low. Guidelines for the use of drugs in the elderly are required and further studies are needed on this issue. PMID: 20200772 [PubMed - in process] (Source: Singapore Medical Journal)

Omeprazole, Surgery Found Effective for Reflux Disease

In patients with chronic gastroesophageal reflux disease, more patients stayed in clinical remission after anti-reflux surgery than with long-term omeprazole, though surgery was associated with postoperative complaints, according to research published in the December issue of Clinical Gastroenterology and Hepatology. (Source: Modern Medicine)

Pharmacokinetics of intravenous omeprazole in critically ill paediatric patients

Abstract&nbsp;&nbsp;The proton pump inhibitors are first-line drugs for the treatment of a number of gastrointestinal diseases. These drugs have a good safety profile, making it possible to use them in paediatric patients. Although their pharmacokinetics in children has not been extensively studied, research performed suggests that the dose used should be varied as a function of age, as this factor affects the drug‚??s metabolism. Proton pump inhibitors can be used in critically ill children for the prophylaxis and treatment of gastrointestinal haemorrhage, although there is still little experience with this. The most widely used proton pump inhibitor at the present time is omeprazole. As there are specific characteristics of these patients that could alter the pharmacokinetics of th...

Surgery, Omeprazole for Reflux Disease Have Different Trade-Offs

Antireflux surgery and omeprazole are both generally well tolerated and effective for gastroesophageal reflux disease (GERD), but long-term outcomes of the two strategies differ in major ways, Scandinavian researchers report in the December issue of Clinical Gastroenterology and Hepatology. Reuters Health Information (Source: Medscape Today Headlines)<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>

Identified Safety Risks With Splitting and Crushing Oral Medications

Emergency nurses are occasionally in a position to administer oral medications to patients who, because of age or a variety of reasons, may not be able to swallow a tablet or capsule. Although some medications can be safely chewed, crushed, or cut (tablet splitting) to assist with administration, there is a growing list of products that, because of their formulations or pharmacokinetic properties, are deemed unsafe to manipulate in this manner. These drug classes are varied and include, but are not limited to, analgesics, cardiovascular medications, nonsteroidal anti-inflammatory agents, antiepileptics, and antibiotics. Drugs that should not be chewed or crushed include commonly used medications such as phenytoin, isosorbide, nifedipine, verapamil, Losec, MS Contin, oxycodone, and erythrom...

OMEPRAZOLE MAGNESIUMcapsule, Delayed Release [Dr. Reddy'S Laboratories Limited]

Updated Date: Dec 23, 2009 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

Barrett's Esophagus

A 56-year-old obese man with long-standing gastroesophageal reflux who recently received a diagnosis of Barrett's esophagus presents for a follow-up visit. He has been taking omeprazole at a dose of 20 mg twice daily and currently has no symptoms of reflux. He has no dysphagia or weight loss. Endoscopic and histopathological examinations show a 4-cm segment of Barrett's esophagus without dysplasia. How should Barrett's esophagus be managed? (Source: New England Journal of Medicine)

PSNC clarifies omeprazole 20mg caps reimbursement price for December 2009

Source: PSNC Area: News According to a notice on the PSNC website, the Department of Health has agreed that "The Drug Tariff Part VIII reimbursement price for Omeprazole 20mg Capsules for December 2009 is £3.99, not £1.77 as printed in December edition of the Drug Tariff".&nbsp; Contractors do not need to endorse the price paid on their prescriptions as the reimbursement price will be applied to all prescriptions submitted for December 09. (Source: NeLM - News)

When One Medication May Not Be Enough

You may be taking an antacid or proton pump inhibitor or h2 blocker, and not finding relief. This may be because a combination of those remedies would control GERD symptoms better. Each type of drug works in a different way, and alone may only control some of the symptoms. Your doctor is the best source to decide which medications would work best for you GERD symptoms. What are these types of medications? Antacids Antacids work by neutralizing acid in the stomach. They are usually the first remedy doctors will recommend patients take to relief heartburn symptoms. Antacids include Rolaids, Maalox, Mylanta, Tums, Gaviscon, and Chooz. H2 Blockers H2 blockers, also called H2 receptor agonists, are medicines that reduce the amount of acid the stomach produces. H2 blockers include Axid, Pe...<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>

Gastrin suppresses the interdependent expression of p16 and anion exchanger 1 favoring growth inhibition of gastric cancer cells

Our previous studies demonstrated that expression and interaction of p16 with anion exchanger 1 (AE1) in gastric cancer cells is correlated with progression and shorter survival of the cancer. In this article, the effects of gastrin on p16 and AE1 and its implication in prevention and treatment of gastric cancer were studied by molecular biology techniques, animal experiment and clinical analysis. The results showed that expression of p16 in human gastric body carcinoma was downregulated along with the progression of the cancer, suggesting the reverse correlations between gastrin and p16 in vivo. Further experiments indicated that gastrin suppressed the expression of p16 via the p16 promoter and thereafter resulted in the degradation of AE1 in gastric cancer cells. Silencing of AE1 or p16 ...

Fatigue, Weight Loss, and Dysphagia in an Older Ma

For 1 month, a 60-year-old white man has had increasing fatigue, generalized weakness, and exertional dyspnea. He becomes short of breath after he walks only 100 to 150 yards on level ground or climbs only 1 flight of stairs. In addition, he has unintentionally lost 12 lb in the past month and has experienced intermittent dysphagia with solid foods. He attributes this last symptom to long-standing gastroesophageal reflux disease (GERD), for which he regularly takes over-the-counter omeprazole. (Source: Consultant Live)

Peritoneal Tuberculosis

A 31-year-old Bangladeshi man presented with dull, aching abdominal pain primarily in the right flank. The pain began a week after he underwent exploratory laparotomy for a perforated duodenal ulcer. He had been taking oxycodone/acetaminophen, docusate sodium, and omeprazole since the surgery. (Source: Consultant Live)

Fatigue, Weight Loss, and Dysphagia in an Older Man

For 1 month, a 60-year-old white man has had increasing fatigue, generalized weakness, and exertional dyspnea. He becomes short of breath after he walks only 100 to 150 yards on level ground or climbs only 1 flight of stairs. In addition, he has unintentionally lost 12 lb in the past month and has experienced intermittent dysphagia with solid foods. He attributes this last symptom to long-standing gastroesophageal reflux disease (GERD), for which he regularly takes over-the-counter omeprazole. (Source: Consultant Live)

The prokinetic effect of mosapride citrate combined with omeprazole therapy improves clinical symptoms and gastric emptying in PPI-resistant NERD patients with delayed gastric emptying

Conclusions&nbsp;&nbsp;Administration of mosapride citrate in addition to omeprazole improved gastro-esophageal reflux and gastric emptying in PPI-resistant NERD patients with delayed gastric emptying. Content Type Journal ArticleCategory Original Article‚??Alimentary TractDOI 10.1007/s00535-009-0173-0Authors Seiji Futagami, Nippon Medical School Division of Gastroenterology, Department of Internal Medicine 1-1-5 Sendagi, Bunkyo-ku Tokyo 113-8602 JapanKatsuhiko Iwakiri, Nippon Medical School Division of Gastroenterology, Department of Internal Medicine 1-1-5 Sendagi, Bunkyo-ku Tokyo 113-8602 JapanTomotaka Shindo, Nippon Medical School Division of Gastroenterology, Department of Internal Medicine 1-1-5 Sendagi, Bunkyo-ku Tokyo 113-8602 JapanTetsuro Kawagoe, Nippon Medical School D...<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>

Omeprazole: Lichenoid eruptions in an elderly patient: case report

(Source: Reactions)

Can proton pump inhibitors be used during pregnancy?

Source: North West Medicines Information Centre Area: Evidence > Medicines Q & A Most documented exposures to proton pump inhibitors (PPIs) during pregnancy have occurred with omeprazole. Although there is some suggestion from one or two studies that omeprazole may be associated with a slightly higher risk of stillbirths or cardiac malformations, these findings may have occurred by chance. A meta-analysis of seven cohort studies documenting 1,530 exposed pregnancies found that administration of PPIs during the first trimester of pregnancy, and specifically omeprazole, does not pose an important teratogenic risk and concludes that PPIs are a reasonable therapeutic option in pregnancy. Although the US Food and Drug Administration (FDA) classifies omeprazole as a higher risk than other...

Gedunin and Photogedunin of Xylocarpus granatum show significant anti-secretory effects and protect the gastric mucosa of peptic ulcer in rats

This study is the first of its kind to show significant anti-secretory effect of gedunin and photogedunin. Therefore it could act as a potent therapeutic agent against peptic ulcer disease. (Source: Phytomedicine)

FDA approves Zegerid for OTC treatment

From Datamonitor via COMTEX (December 3, 2009) Merck & Co has reported that the FDA has approved Zegerid OTC for over-the-counter treatment of frequent heartburn. Zegerid OTC will be marketed over-the-counter (OTC) by Schering-Plough... (Source: Drugs.com - Pharma News)

Zegerid OTC Approved for Frequent Heartburn

Title: Zegerid OTC Approved for Frequent HeartburnCategory: Health NewsCreated: 12/2/2009 2:10:00 PMLast Editorial Review: 12/3/2009 (Source: MedicineNet Crohn's Disease General)<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>

Santarus Announces FDA Approval Of Schering-Plough HealthCare Products' ZEGERID OTC

Santarus, Inc. (NASDAQ: SNTS), a specialty biopharmaceutical company, today announced that the U.S. Food and Drug Administration (FDA) has approved Schering-Plough HealthCare Products, Inc.'s, New Drug Application (NDA) for ZEGERID OTC‚?Ę Capsules (omeprazole/sodium bicarbonate) with a dosage strength of 20 mg of omeprazole for over-the-counter (OTC) treatment of frequent heartburn. Schering-Plough and Merck & Co., Inc. merged on November 3, 2009. The OTC heartburn market in the U.S. is estimated at $1.7 billion based on data from Information Resources, Inc... (Source: Health News from Medical News Today)

Zegerid OTC Approved for Frequent Heartburn

In original prescription formula Source: HealthDay Related MedlinePlus Topic: Heartburn (Source: MedlinePlus Health News)<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>

FDA Approves OTC Version Of Heartburn Drug Zegerid

WHITEHOUSE STATION, N.J.--Merck & Co. and Santarus Inc. said Tuesday the Food and Drug Administration approved Merck‚??s over-the-counter version of the Santarus prescription heartburn drug Zegerid. San Diego-based Santarus had partnered with... (Source: Drugs.com - New Drug Approvals)

FDA Approves OTC Version of Heartburn Drug Zegerid

From Associated Press (December 2, 2009) WHITEHOUSE STATION, N.J.--Merck & Co. and Santarus Inc. said Tuesday the Food and Drug Administration approved Merck's over-the-counter version of the Santarus prescription heartburn drug Zegerid. San... (Source: Drugs.com - Pharma News)

FDA Approves ZEGERID OTC(TM) For Over-the-Counter Treatment Of Frequent Heartburn

Merck & Co., Inc. announced that the U.S. Food and Drug Administration (FDA) has approved ZEGERID OTC(TM) (omeprazole 20 mg/sodium bicarbonate 1100 mg capsules), for over-the-counter treatment of frequent heartburn. ZEGERID OTC will be marketed over-the-counter by Schering-Plough HealthCare Products, Inc., the consumer healthcare division of Merck & Co., Inc. Schering-Plough and Merck merged on November 3, 2009. ZEGERID OTC is a proton pump inhibitor (PPI), the strongest and most effective class of acid-reducing medications available for frequent heartburn... (Source: Health News from Medical News Today)

Zegerid OTC Approved for Frequent Heartburn

(Source: Modern Medicine)<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>

FDA Approves ZEGERID OTC(TM) for Over-the-Counter Treatment of Frequent Heartburn

Unique Dual-Ingredient Formulation Available for 24-Hour Frequent Heartburn Relief Without A Prescription WHITEHOUSE STATION, N.J., Dec. 1 (HSMN NewsFeed) -- Merck & Co., Inc. today announced that the U.S. Food and Drug Administration (FDA) has approv... Biopharmaceuticals, FDAMerck, Schering-Plough, ZEGERID OTC, omeprazole, proton pump inhibitor (Source: HSMN NewsFeed)

FDA Approves ZEGERID OTC&trade; for Over-the-Counter Treatment of Frequent Heartburn

(Source: Merck.com - Product News)

FDA: Don't Mix Certain PPIs With Clopidogrel

The Food and Drug Administration is recommending that patients not take clopidogrel and omeprazole together, on the basis of new data recently submitted to the agency indicating that the effectiveness of the antiplatelet drug is reduced when taken with the proton pump inhibitor, according to a public health advisory issued by the FDA. (Source: Cardiology News)

News From the FDA

Patients should not take clopidogrel and omeprazole together because the effectiveness of the antiplatelet drug is reduced when taken with the proton pump inhibitor, according to a public health advisory issued by the Food and Drug Administration. (Source: Internal Medicine News)

[Delayed hypersensitivity to sodium lauryl sulphate in omeprazole.]

Authors: Schmutz JL, Barbaud A, Trechot P PMID: 20004328 [PubMed - in process] (Source: Annales de Dermatologie et de Cenereologie)<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>

A 52-Year-Old Man With Heartburn: Should He Undergo Screening for Barrett's Esophagus?

A 52-year-old man is referred to your gastroenterology practice for a history of gastroesophageal reflux disease (GERD). The patient reports a long history of heartburn symptoms, dating back at least 5 years. His symptoms were responsive to over-the-counter remedies including antacid tablets and liquids, but eventually became such a regular occurrence that he sought medical care from his primary care physician. He was initially prescribed an H2 blocker, which was incompletely effective, so he was started on proton pump inhibitor therapy. He currently takes 20 mg of omeprazole daily which is effective, but notes that if he misses a dose, he sometimes experiences heartburn. He denies dysphagia, nausea or vomiting, blood in his stool, or unintentional weight loss. He has no other chronic medi...

Updated Safety Information about a drug interaction between Clopidogrel Bisulfate (marketed as Plavix) and Omeprazole (marketed as Prilosec and Prilosec OTC)

Source: Food and Drug Administration Related MedlinePlus Topics: Heart Attack, Stroke (Source: MedlinePlus Health News)

FDA Advises Against Use of Clopidogrel With Omeprazole, Other Drugs

The FDA has issued a public health advisory warning consumers to avoid using the stomach acid reducer omeprazole, which is marketed in prescription and OTC formulations as Prilosec, with the anticlotting drug clopidogrel, which is marketed as Plavix. (Source: AAFP Health of the Public)

Gemfibrozil-Induced Myositis in a Patient with Normal Renal Function (January).

CONCLUSIONS: Although the risk of myositis appears to be low with gemfibrozil monotherapy, clinicians should be aware of the potential for this adverse event. For patients taking gemfibrozil monotherapy who present with myalgia, discontinuation of the medication may be necessary for the alleviation of pain. PMID: 19934390 [PubMed - as supplied by publisher] (Source: The Annals of Pharmacotherapy)

POZEN Announces Start Of Enrollment For PA32540 Phase 3 Program

POZEN Inc. (NASDAQ: POZN) announced the start of enrollment for the phase 3 studies for PA32540. PA32540 is a fixed-dose combination of 325 mg of enteric coated aspirin and 40 mg of immediate release omeprazole, under investigation for use in the secondary prevention of heart attacks and strokes in patients at risk for associated gastric ulcers. (Source: Health News from Medical News Today)<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>

FDA warns of clopidogrel/omeprazole interaction

(Source: Reactions)

FDA Announces New Warning On Plavix: Avoid Use With Prilosec/Prilosec OTC

Patients should avoid using the stomach acid reducer Prilosec/Prilosec OTC (omeprazole) with the anti-clotting drug Plavix (clopidogrel), the U.S. Food and Drug Administration warned on Nov. 17. New data suggest that when patients take both Prilosec and Plavix, Plavix's ability to block platelet aggregation (anti-clotting effect) may be reduced by about half. (Source: Health News from Medical News Today)

Did FDA ignore COGENT to slap warning on clopidogrel/PPI interaction?

The FDA is requiring a labeling change to Sanofi-Aventis and Bristol-Myers Squibb‚??s blockbuster anti-bloodclotting drug clopidogrel (Plavix) to indicate that it should not be used with AstraZeneca‚??s proton pump inhibitor (PPI) omeprazole (Prilosec/Prilosec OTC) and some other acid-reducing drugs. (Source: Cardiovascular Business News)

FDA Announces New Warning on Plavix: Avoid Use with Prilosec/Prilosec OTC

Source: Food and Drug Administration Related MedlinePlus Topics: Blood Thinners, GERD, Heartburn (Source: MedlinePlus Health News)<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>

Pharmacokinetic profile of immediate-release omeprazole in patients with gastro-oesophageal reflux associated with gastroparesis

Conclusions Immediate-release omeprazole was associated with a more rapid absorption and less variable pharmacokinetic profile compared with delayed-release omeprazole in reflux patients associated with gastroparesis. (Source: Alimentary Pharmacology and Therapeutics)

FDA Announces New Warning on Plavix: Avoid Use with Prilosec/Prilosec OTC

Patients should avoid using the stomach acid reducer Prilosec/Prilosec OTC (omeprazole) with the anti-clotting drug Plavix (clopidogrel), the U.S. Food and Drug Administration warned on Nov. 17. (Source: Food and Drug Administration)

FDA: Clopidogrel's Antiplatelet Effect Can Be Halved by Omeprazole

(Source: Physician's First Watch current issue)

FDA: Effect of clopidogrel reduced when used with omeprazole

(Source: HemOncToday.com)

Cardiologists Shocked by New FDA Alert on Clopidogrel-PPI Interaction

The FDA has issued a new warning on an interaction between clopidogrel and the PPI omeprazole and other drugs that inhibit the CYP2C19 enzyme, just weeks after the only randomized trial on this issue reported no such interaction. Heartwire (Source: Medscape Medical News Headlines)<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>

FDA issues advice regarding omeprazole and clopidogrel drug interaction

Source: FDA Area: News The FDA has notified healthcare professionals in the US of new data concerning an interaction between clopidogrel (Plavix¬ģ) and omeprazole (Prilosec/Prilosec OTC), showing that when these drugs are co-administered, the effectiveness of clopidogrel is reduced. &nbsp; In addition to a MedWatch alert, the FDA has issued a Public Health Advisory, Information for Healthcare Professionals, and a follow-up to its previous Early Communication (January 2009) regarding this interaction (all are available to view via the link below). &nbsp; The FDA highlights the following considerations for healthcare professionals: &nbsp; .&nbsp;The concomitant use of omeprazole and clopidogrel should be avoided because of the effect on clopidogrel's active metabolite levels and...

Heartburn Drugs Can Interfere with Plavix

FDA Says Drugs Like Prilosec and Nexium May Reduce Efficacy of Blood-Thinner Plavix, Used to Prevent Heart Attack (Source: Health News: CBSNews.com)

Cardiologists Shocked by New FDA Alert on Clopidogrel-PPI Interaction

Clopidogrel may not be as effective when taken with omeprazole, the FDA announced today, and the agency is warning clinicians to avoid concomitant use of the drugs. Heartwire (Source: Medscape Today Headlines)

Cardiologists shocked by new FDA alert on clopidogrel-PPI interaction

The FDA has issued a new warning on an interaction between clopidogrel and the PPI omeprazole and other drugs that inhibit the CYP2C19 enzyme, just weeks after the only randomized trial on this issue reported no such interaction. (Source: theHeart.org)

FDA warns heartburn drugs interfere with Plavix

WASHINGTON (Reuters) - Common heartburn pills Prilosec and Nexium cut the blood-thinning effect of Sanofi-Aventis SA's and Bristol-Myers Squibb Co's heart drug Plavix, U.S. officials warned on Tuesday. (Source: Reuters: Health)

AHA: FDA Drops Clopidogrel Bomb at AHA

ORLANDO (MedPage Today) -- The FDA has issued a public health advisory warning patients and physicians that concommitant use of clopidogrel (Plavix) and omeprazole (Prilosec and Prilosec OTC) blunts the antiplatelet effect of clopidogrel, thus increasing the risk of myocardial infarction and stroke. (Source: MedPage Today Cardiovascular)

FDA says Prilosec can block benefits of Plavix

Federal health officials said Tuesday a popular heartburn medication can interfere with the blood thinner Plavix, a drug taken by millions of Americans to reduce risks of heart attack and stroke. (Source: CTV Health)

Prilosec can block benefits of Plavix, FDA warns

A popular heartburn medication can interfere with the blood thinner Plavix, a drug taken by thousands of Canadians to reduce risks of heart attack and stroke, U.S. health authorities are warning. (Source: CTV Health)

FDA Says Prilosec Can Block Benefits of Plavix

From Associated Press (November 17, 2009) WASHINGTON‚??Federal health officials say a popular heartburn medication can block the blood thinning effect of Plavix, which is taken by millions of Americans to reduce risks of heart attack and... (Source: Drugs.com - Pharma News)<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>

Clopidogrel (marketed as Plavix) and Omeprazole (marketed as Prilosec) - Drug Interaction

Effectiveness of clopidogrel is reduced when taken with omeprazole, placing patients who use clopidogrel to prevent blood clots at risk for heart attacks or strokes if they are also taking omeprazole. (Source: FDA MedWatch)

Certain Reflux Drugs Tied to Higher Post-Angioplasty Death Rate

Study suggests interaction between Prilosec, Protonix and blood-thinners such as Plavix (Source: The Doctors Lounge - Gastroenterology)

GERD in the School-Age Child

Dr. Gold is an attending pediatric gastroenterologist at Children's Healthcare of Atlanta and a member of the Children's Center for Digestive Healthcare. He is also a former professor of pediatrics and microbiology, and former director of the division of pediatric gastroenterology, hepatology, and nutrition, at Emory University in Atlanta. Dr. Gold previously was a consultant for AstraZeneca, maker of Losec (omeprazole) and Nexium (esomaprazole), and Takeda Pharmaceuticals, maker of Prevacid (lansoprazole). To respond to this column, e-mail Dr. Gold at fpnews@elsevier.com. (Source: Family Practice News)<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>

Omeprazole/soya oil emulsion: Anaphylaxis: 2 case reports

(Source: Reactions)

Inversed Y cardioplasty plus a truncal vagotomy-antrectomy and a Roux-en-Y gastrojejunostomy performed in patients with stricture of the esophagogastric junction after a failed cardiomyotomy or endoscopic procedure in patients with achalasia of the esophagus

Laparoscopic anterior cardiomyotomy in addition to anterior Dor's fundoplication is the procedure of choice for achalasia of the esophagus with approximately 95% success rate. Redo cardiomyotomy is complicated and associated with rerecurrence of dysphagia. Twelve patients with failed redo myotomy were clinically evaluated with radiology, endoscopy, and manometry in whom achalasia type III or IV was confirmed. We propose as treatment for these selected cases an inversed Y cardioplasty + truncal vagotomy, a partial distal gastrectomy and Roux-en-Y gastrojejunostomy in order to facilitate esophageal emptying and avoid the appearance of postoperative gastroesophageal reflux as a side effect of this procedure. One patient was reoperated on in order to enlarge the cardioplasty. Disappearance of ...

Pharmacogenetics of CYP2C19: functional and clinical implications of a new variant CYP2C19*17

WHAT IS ALREADY KNOWN ABOUT THIS SUBJECT [bull] CYP2C19 polymorphisms may have clinical consequences in relation to drugs extensively metabolized by the enzyme. [bull] Recently a new variant CYP2C19*17 was discovered. [bull] Unlike other commonly studied variant alleles, notably CYP2C19*2 and CYP2C19*3, which are defective, CYP2C19*17 is associated with enhanced enzyme activity and three CYP2C19 phenotypes have been suggested: ultrarapid metabolizers (UM), extensive metabolizers (EM) and poor metabolizers (PM). [bull] There appears to be interethnic variability in the prevalence of the CYP2C19*17 allele. WHAT THIS STUDY ADDS [bull] We provide the first critical quantitative review of this rapidly developing area of research to serve as a basis for subsequent research and overviews. [bull] ...

Quadruple therapy with ecabet sodium, omeprazole, amoxicillin and metronidazole is effective for eradication of Helicobacter pylori after failure of first-line therapy (KDOG0201 Study)

Conclusions: Quadruple therapy including ecabet sodium is useful as second-line eradication treatment for H. pylori. (Source: Journal of Clinical Pharmacy and Therapeutics)

LAC and LOAD: 4-Drug Regimen Better at Eliminating H. Pylori Than Standard 3-Drug Treatment

LOAD (levofloxacin, omeprazole, nitazoxanide, and doxycycline) is more effective at eradicating Helicobacter pylori than LAC (lansoprazole, amoxicillin, and clarithromycin). Medscape Medical News (Source: Medscape Today Headlines)<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>

LAC and LOAD: 4-Drug Regimen Better at Eliminating H Pylori Than Standard 3-Drug Treatment

LOAD (levofloxacin, omeprazole, nitazoxanide, and doxycycline) is more effective at eradicating Helicobacter pylori than LAC (lansoprazole, amoxicillin, and clarithromycin). Medscape Medical News (Source: Medscape Gastroenterology Headlines)

A Novel Composite Endpoint to Evaluate the Gastrointestinal (GI) Effects of Nonsteroidal Antiinflammatory Drugs Through the Entire GI Tract.

CONCLUSION: By providing clinicians with a new, descriptive language for adverse events through the entire GI tract, the CSULGIE endpoint has the potential to become a standard tool for evaluating the GI effects of a range of therapies. PMID: 19884267 [PubMed - as supplied by publisher] (Source: J Rheumatol)

Exam 1: Comparison of Outcomes Twelve Years After Antireflux Surgery or Omeprazole Maintenance Therapy for Reflux Esophagitis

(Source: Clinical Gastroenterology and Hepatology)

Interleukin-1ő≤ Promotes Gastric Atrophy Through Suppression of Sonic Hedgehog

Conclusions: IL-1ő≤ suppresses Shh gene expression in parietal cells by inhibiting acid secretion and subsequently the release of intracellular calcium. (Source: Gastroenterology)

---

In this study, the use of intravenous cimetidine (CM) in a small number of infants with HPS is presented. Over a 28-month period, 32 HPS cases, including a sub-group of 17 infants (aged 7-9 weeks) with arterial pH >7.60, were admitted to a tertiary referral unit. Four infants in this sub-group were treated with standard resuscitation fluids for 4 days prior to intravenous CM, while 12 infants received CM immediately. Intravenous CM (10 mg/kg) was given twice daily until arterial pH was less than 7.50. In one case, intravenous omeprazole at 0.1 mg/kg was given instead of CM. In all 17 cases, CM treatment or omeprazole therapy (for 12-48 h) reduced pH to less than 7.50, thus allowing for Ramstedt pyloromyotomy the same day. These patients were allowed oral feeding on the following day and we...<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>

Dysphagia associated with an elevated amylase level

A 34-year-old woman with a history of gastric ulcers, GERD, and asthma presented for endoscopic evaluation of recurrent dyspepsia and 2 months of dysphagia for solids. She denied odynophagia, weight loss, early satiety, and fever. Her medications included omeprazole and albuterol. Physical examination was unremarkable. Laboratory data were pertinent only for a mildly elevated serum amylase levels of 212 U/L and 180 U/L (normal range 30-110 U/L) with normal lipase levels on consecutive phlebotomies. An EGD revealed extrinsic compression of the distal esophagus (A) and a clean-based antral ulcer; testing for Helicobacter pylori was negative. A CT scan of the chest documented a 3.5 √? 2.0-cm, rounded, smooth-walled soft tissue mass in the anterior border of the distal esophagus (B). An EUS re...

New Combination Therapy Looks Promising Against Ulcer Bacteria

Helicobater pylori, a bacteria implicated in peptic ulcers and gastritis, was eradicated in 95 percent patients who took a 7-day course of combination therapy with levofloxacin, omeprazole, nitazoxanide (Alinia¬ģ) and doxycycline (LOAD) compared to eradication in only 80.9 percent of patients on lansoprazole, amoxicillin and clarithromycin (LAC) for seven days. (Source: Health News from Medical News Today)

Positive Data From Two Investigator-Initiated Studies With Santarus' ZEGERID To Be Presented At ACG

Santarus, Inc. (NASDAQ: SNTS), a specialty biopharmaceutical company, announced that positive data from two investigator-initiated studies with ZEGERID¬ģ (omeprazole/sodium bicarbonate) will be presented in poster sessions at the American College of Gastroenterology (ACG) 2009 Annual Scientific Meeting taking place in San Diego. These studies were supported by grants from Santarus. (Source: Health News from Medical News Today)

Nexium 10mg granules, 20mg and 40mg tablets, 40mg injection (esomeprazole) - Revised SPC

Source: eMC (electronic Medicines Compendium) Area: Other Library Updates > SPC Changes Revised SPC to include updates to: Section 4.3 - Esomeprazole should not be used concomitantly with nelfinavir (See section 4.5) Section 4.4 - Co-administration of esomeprazole with atazanavir is not recommended (see section 4.5). If the combination of atazanavir with a proton pump inhibitor is judged unavoidable, close clinical monitoring is recommended in combination with an increase in the dose of atazanavir to 400 mg with 100 mg of ritonavir; esomeprazole 20 mg should not be exceeded. Section 4.5 - Omeprazole has been reported to interact with some protease inhibitors. The clinical importance and the mechanisms behind these reported interactions are not always known. Increased gastric pH du...

Interaction between liquid protein solution and omeprazole suspension.

Authors: Freeman KL, Trezevant MS PMID: 19850779 [PubMed - in process] (Source: American Journal of Health-System Pharmacy : AJHP)<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>

Clinical research The effect of treatment on lipid peroxidation in patients with subarachnoid haemorrhage

Conclusions: Surgical and pharmacological treatment of SAH patients restored prooxidant-antioxidant balance. Evaluation of TBARS and CD level, in SAH patients&#8217; peripheral blood may help to monitor the therapy efficiency in normalization of CNS oxygen metabolism. (Source: Articles of Archives of Medical Science - TERMEDIA publishing house)

Omeprazole: Acute interstitial nephritis in an elderly patient: case report

(Source: Reactions)

Omeprazole: Toxic epidermal necrolysis and neutropenia: case report

(Source: Reactions)

Pharmacogenetics of Phase I and Phase II Drug Metabolism.

Authors: Crettol S, Petrovic N, Murraya M Genetic variation in the receptors and other intracellular targets that mediate the pharmacodynamic effects of drugs can affect therapeutic outcomes. However, at present greater knowledge is available concerning the extent of gene variation in drug metabolizing enzymes that determine drug pharmacokinetics and, in turn, drug efficacy and toxicity. Information on the incidence of polymorphisms in the cytochrome P450 (CYP) genes that mediate phase I biotransformation is increasing, although the level of detail in the case of phase II conjugation enzymes, such as the UDP-glucuronosyltransferases (UGTs) and N-acetyltransferases (NATs), is not as extensive. It is now apparent that defective alleles that encode variant CYPs, UGTs, NATs and other biotr...

Long-term treatment with proton pump inhibitor is associated with undesired weight gain.

CONCLUSION: Long-term PPI treatment was associated with BW gain in patients with GERD. Reflux patients receiving PPI should be encouraged to manage BW through lifestyle modifications. PMID: 19824113 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>

Proton pump inhibitor linked to pneumonia deaths in hospitalized patients

(NaturalNews) Proton pump inhibitors (PPIs, for short) have become hugely successful money makers for Big Pharma over the past decade, with sales of these stomach-acid reducers adding up to about $25.6 billion last year alone. The drugs (like Prilosec, Nexium, Prevacid and Aciphex) are sold both in prescription strength and over-the-counter to treat heartburn and gastroesophageal reflux disease (GERD). As NaturalNews has previously reported, PPIs are not the safe and innocuous medications most physicians claim them to be and are increasingly linked to a host of side effects. Now comes word that one type of PPI in particular, pantoprazole (marketed under the name Protonix) has a particularly bad downside -- causing potentially fatal pneumonia people who are already seriously ill and hospita...

Involvement of cytochrome P450 3A4 and P-glycoprotein in first-pass intestinal extraction of omeprazole in rabbits.

Conclusion:Oral omeprazole undergoes marked extraction in the small intestine, and increased bioavailability of the drug after id administration of ketoconazole and verapamil suggests that this increase results from inhibition of CYP3A4 and P-gp function in the intestine rather than the liver. PMID: 19820718 [PubMed - as supplied by publisher] (Source: Acta Pharmacologica Sinica)

Pantoprazole Better Than Omeprazole for Clopidogrel-Treated Patients

In patients with coronary stents for non-ST-segment elevation acute coronary syndrome, use of pantoprazole instead of omeprazole as a proton pump inhibitor (PPI) allows a better platelet response to clopidogrel, French researchers report. Reuters Health Information (Source: Medscape Today Headlines)

PRILOSEC (Omeprazole Magnesium) Capsule, Delayed Release PRILOSEC (Omeprazole Magnesium) Granule, Delayed Release [AstraZeneca LP]

Updated Date: Oct 2, 2009 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

GERD in the School-Age Child

Dr. Gold is an attending pediatric gastroenterologist at Children's Healthcare of Atlanta and a member of the Children's Center for Digestive Healthcare. He is also a former professor of pediatrics and microbiology, and former director of the division of pediatric gastroenterology, hepatology, and nutrition, at Emory University in Atlanta. Dr. Gold previously was a consultant for AstraZeneca, maker of Losec (omeprazole) and Nexium (esomaprazole), and Takeda Pharmaceuticals, maker of Prevacid (lansoprazole). To respond to this column, e-mail Dr. Gold at pdnews@elsevier.com. (Source: Pediatric News)<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>

Nanoparticulation of poorly water soluble drugs using a wet-mill process and physicochemical properties of the nanopowders.

Authors: Tanaka Y, Inkyo M, Yumoto R, Nagai J, Takano M, Nagata S In order to improve the dissolution and oral absorption properties of poorly water soluble drugs such as omeprazole, albendazole and danazol, various dispersing agents were added to prepare nanopowder formulations using an ULTRA APEX MILL, which is a wet-mill instrument, and their physicochemical properties were evaluated. Using Pluronic F-108 or F-68 as dispersing agents, slurries containing drug particles having nanometer size were obtained for all model drugs tested. Omeprazole, a heat labile drug, was not degraded by wet-milling and the omeprazole nanoparticles in a milled slurry did not aggregate for 24 h after wet-milling. After lyophilization of these milled slurries containing drug nanoparticles, fine solid white...

Fibromuscular dysplasia of ostial left main coronary artery depicted by intravascular ultrasound

A 32-year-old woman with no known cardiac risk factors was admitted at 12 weeks' gestation with exertional chest pain and shortness of breath. Four months prior, she noted severe exertional left-sided chest pressure. Her primary care physician had prescribed omeprazole and albuterol which did not improve her symptoms. One week prior, she developed left-sided chest pain radiating to the left arm which lasted for 20 min. An ECG obtained at the office visit that day was unremarkable. She was referred to our center for a stress echocardiogram. The treadmill stress test was stopped at 3 min after she developed chest pain. The ECG revealed 2- to 3-mm horizontal ST depressions in leads II, III, aVF, and V3‚??V6 (). The stress echocardiogram showed severe hypokinesis of the anterior and lateral wa...

PPIs to Prevent NSAID-Induced GI Ulcers

DR. EBBERT and DR. TANGALOS are with the Mayo Clinic in Rochester, Minn. They have no conflict of interest to report. A 57-year-old man with a history of coronary artery disease and severe degenerative joint disease status post right shoulder rotator cuff tear repair, right total knee arthroscopy, left knee meniscal tear repair, and three spinal fusions presents to you for pain management issues. He is on long-term narcotics with oxycodone. He presented 3 months earlier to the emergency department (ED) with dysphagia and odynophagia. His hemoglobin level was normal, and he denied gastrointestinal bleeding. At the time of presentation, he was taking naproxen sodium (440 mg in the morning and 220 mg in the evening) for joint pain as he was trying to taper his narcotic regimen. Esophagogastr...

Comparison of azithromycin and metronidazole in a quadruple-therapy regimen for &lt;i&gt;Helicobacter pylori&lt;/i&gt; eradication in dyspepsia

Conclusion: &#x0026;lt;/b&#x0026;gt; No significant difference exists between the two quadruple-therapy regimens that were tested. (Source: The Saudi Journal of Gastroenterology)

Esomeprazole/omeprazole: First report of microscopic colitis: 4 case reports

(Source: Reactions)<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>

Food-Induced Severe Chest Pain and Hematemesis

Question: An 88-year-old woman ate dry, crispy Yorkshire pudding causing slight epigastric pain. Thirty minutes later she developed sudden-onset, severe, central chest pain radiating to the back and epigastrium, associated with shortness of breathe and bouts of hematemesis. She had a background of mild gastritis and reflux esophagitis for which she was taking omeprazole. (Source: Gastroenterology)

Lack Of Adverse Interaction Between Clopidogrel And Stomach Medicine Shown By Cogent Trial

Results from a late breaking clinical trial called COGENT demonstrate that the combination of giving patients clopidogrel, a blood thinner commonly prescribed to patients with cardiovascular disease, and stomach medicines such as omeprazole, known as proton pump inhibitors (PPIs), did not lead to adverse events, as some prior studies had suggested. (Source: Health News from Medical News Today)

COGENT: No CV Events But Significant GI Benefits of PPI Omeprazole

The randomized controlled trial results should put a stop to alarmist headlines about PPIs blunting efficacy of antiplatelet drugs, experts say. By withholding PPIs, physicians are doing more harm than good, the results suggest. Heartwire (Source: Medscape Medical News Headlines)

COGENT: No CV events but significant GI benefits of PPI omeprazole

The randomized controlled trial results should put a stop to alarmist headlines about PPIs blunting efficacy of antiplatelet drugs, experts say. By withholding PPIs, physicians are doing more harm than good, the results suggest. (Source: theHeart.org)

CVN: COGENT Trial

COGENT: A Prospective, Randomized, Placebo-Controlled Trial of Omeprazole in Patients Receiving Aspirin and Clopidogrel (Source: Cardiosource)<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>

Clinical Trial Summary: Clopidogrel and the Optimization of GI Events Trial (COGENT&nbsp;&#8212;&nbsp;Presented at TCT 2009)

A few platelet studies have indicated that proton pump inhibitors (PPIs), specifically omeprazole, are associated with reduced antiplatelet efficacy of clopidogrel, when used together. In addition, the use of dual antiplatelet therapy is often fraught with problems of gastrointestinal (GI) bleeding . . . (Source: Cardiosource)

Cogent trial shows lack of adverse interaction between clopidogrel and stomach medicine

(Cardiovascular Research Foundation) Results from a late breaking clinical trial called COGENT demonstrate that the combination of giving patients clopidogrel, a blood thinner commonly prescribed to patients with cardiovascular disease, and stomach medicines such as omeprazole, known as proton pump inhibitors, did not lead to adverse events, as some prior studies had suggested. The results were presented at the 21st annual Transcatheter Cardiovascular Therapeutics scientific symposium, sponsored by the Cardiovascular Research Foundation. (Source: EurekAlert! - Medicine and Health)

Case-report: severe allergic reactions due to soya oil in a generic formulation

Source: NEJM Area: News A case report in the New England Journal of Medicine discusses two Spanish patients who suffered anaphylactic reactions after taking generic omeprazole capsules despite no history of reaction to the branded product. Both had significant hypotension (systolic BP &lt;90mmHg) and breathing difficulties within minutes of ingesting the capsules. &nbsp; Subsequent investigation found that the capsules contained soya oil as an excipient. Both patients showed significant reactions to skin-prick testing with soya extract and with extracts of two different generic omeprazole capsule contents, but not with extracts of the branded capsule contents. When five patients known to be allergic to soya were skin-prick tested with the generic capsule extracts, they also had positi...

Comparison of Omeprazole and Pantoprazole Influence on a High 150-mg Clopidogrel Maintenance Dose: The PACA (Proton Pump Inhibitors And Clopidogrel Association) Prospective Randomized Study

Conclusions: The present findings suggest the preferential use of pantoprazole compared with omeprazole in patients receiving clopidogrel to avoid any potential negative interaction with CYP2C19. (Source: Journal of the American College of Cardiology)

Eltrombopag, an oral thrombopoietin receptor agonist, has no impact on the pharmacokinetic profile of probe drugs for cytochrome P450 isoenzymes CYP3A4, CYP1A2, CYP2C9 and CYP2C19 in healthy men: a cocktail analysis

Conclusion&nbsp;&nbsp;Once-daily administration of eltrombopag 75&nbsp;mg for 7&nbsp;days did not alter CYP3A4, CYP1A2, CYP2C9 or CYP2C19 activity in healthy volunteers. Content Type Journal ArticleCategory Pharmacokinetics and DispositionDOI 10.1007/s00228-009-0716-6Authors Julian Jenkins, GlaxoSmithKline Research & Development Oncology Medicine Development Center 1250 Collegeville Road Collegeville PA 19426 USADaphne Williams, GlaxoSmithKline Research Triangle Park Durham NC USAYanli Deng, GlaxoSmithKline Research & Development Oncology Medicine Development Center 1250 Collegeville Road Collegeville PA 19426 USADavid A. Collins, GlaxoSmithKline Research Triangle Park Durham NC USAValerie S. Kitchen, GlaxoSmithKline Research & Development Oncology Medicine Development Center 125...<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>

Omeprazole, But Not Pantoprazole, Inhibits Clopidogrel's Platelet Response

The use of omeprazole significantly reduced the antiplatelet activity of clopidogrel, even with a high maintenance dose of the drug, and other PPIs, such as pantoprazole, should be preferred in clopidogrel-treated patients, according to investigators. Heartwire (Source: Medscape Today Headlines)

Omeprazole, but not pantoprazole, inhibits clopidogrel's platelet response

The use of omeprazole significantly reduced the antiplatelet activity of clopidogrel, even with a high maintenance dose of the drug, and other PPIs, such as pantoprazole, should be preferred in clopidogrel-treated patients, according to investigators. (Source: theHeart.org)

Use of (S)-BINOL as NMR chiral solvating agent for the enantiodiscrimination of omeprazole and its analogs.

Authors: Redondo J, Capdevila A, Latorre I The application of (S)-1,1'-binaphthyl-2,2'-diol as NMR chiral solvating agent (CSA) for omeprazole, and three of its analogs (lanso-, panto-, and rabe-prazole) was investigated. The formation of diastereomeric host-guest complexes in solution between the CSA and the racemic substrates produced sufficient NMR signal splitting for the determination of enantiomeric excesses by (1)H- or (19)F-NMR spectroscopy. Using of hydrophobic deuterated solvents was mandatory for obtaining good enantiodiscrimination, thus suggesting the importance of intermolecular hydrogen bonds in the stabilization of the complexes. The method was applied to the fast quantification of the enantiomeric purity of in-process samples of S-omeprazole. Chirality, 2009. (c) 2009 ...

Influence of number of calibration standards within a defined range on pharmacokinetic disposition-case studies with omeprazole and clopidogrel carboxylic acid.

Authors: D'Souza HJ, Pai B, Kumar A, Shekar R, Srinivas NR, Kristjansson F While the practice of using a smaller number of non-zero standards (typically seven to eight) has not been entertained in routine bioanalytical work, it is important to innovate and be pragmatic about minimizing the number of calibration standards to promote cost-effective and speedy assessment. In this exercise, two important compounds, omeprazole and clopidogrel carboxylic acid, were considered. Additionally, both analytes offered a 1000-fold calibration curve range with eight non-zero standards to permit a systematic evaluation. Accordingly various scenarios of post-hoc analysis of the calibration data were formulated which included step-wise reduction of the number of calibration standards from a maximum of ...

How should continuous infusions of proton pump inhibitors be given for acute upper gastrointestinal bleeding?

Source: Wessex Drug and Medicines Information Centre Area: Evidence > Medicines Q & A For omeprazole, pantoprazole and esomeprazole, limited evidence suggests that optimal effect is achieved with an iv bolus dose of 80mg, followed by continuous infusion of 8mg/hour for 3 days. &nbsp; After administration of the initial bolus dose, the continuous infusion can be prepared by reconstituting a 40mg vial of either omeprazole (Losec¬ģ) or pantoprazole and further diluting in 100ml of sodium chloride 0.9%. This can be given at a rate of 8mg/hour (i.e. over 5 hours), and repeated with a fresh vial after that time. Depending on the host organisation's attitude to microbiological stability, infusions could be made up and run over 24-48 hours if necessary since omeprazole (Losec¬ģ) and pant...<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>

Importance of CYP2C19 genetic polymorphism in the eradication of Helicobacter pylori in north Indians.

CONCLUSION: This study demonstrated a direct correlation between CYP2C19 genetic polymorphism and H. pylori eradication in north Indian patients with gastritis. Knowing the CYP2C19 phenotype of a patient may help in prescribing optimum dose of proton pump inhibitor to achieve better therapeutic outcome. PMID: 19942749 [PubMed - as supplied by publisher] (Source: Indian J Med Res)

Antral ulcers induced by alendronate, a nitrogen-containing biphophonate, in rat stomachs - prophylactic effect of rebamipide.

Authors: Ohashi Y, Aihara E, Takasuka H, Takahashi K, Takeuchi K We demonstrated the development of antral ulcers induced in rats by alendronate and investigated the pathogenic factors involved in this model. Animals fasted for 18 h were given alendronate p.o., and then re-fed normally and killed on various days up to 7 days later. Alendronate caused non-hemorrhagic damage in both the corpus and antrum of fasted rats, but after refeeding for 3 days the lesions in the corpus healed completely, while those in the antrum developed into large ulcers with increased vascular permeability. The development of antral ulcers was accompanied by an increase in MPO activity and lipid peroxidation as well as a decrease in SOD activity and GSH content in the mucosa. Histologically, the damage did not...

Heartburn drugs don't interfere with Plavix: study

BARCELONA (Reuters) - Heartburn pills like Nexium and Prilosec do not stop blood-thinning drugs such as Plavix from working effectively, contrary to recent fears, new research on Monday showed. (Source: Reuters: Health)

OMEPRAZOLE DELAYED-RELEASE (Omeprazole) Capsule, Delayed Release [Ranbaxy Laboratories Inc.]

Updated Date: Aug 26, 2009 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

Eradication of Helicobacter pylori can facilitate immune reconstitution in HIV-1-infected immunological non-responders

Conclusion: Triple therapy for H. pylori eradication is associated with a significant, although possibly transient immune reconstitution in HAART-treated HIV-1 patients with viral suppression without immunological response. (Source: International Journal of Infectious Diseases)<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>

A patient with osteoarthritis and cardiovascular disease presenting with bilateral hip pain: a case report

Conclusion: The addition of a proton pump inhibitor to nonsteroidal anti-inflammatory drug therapy can reduce the risk of peptic ulcer bleeding by (equal to or greater than) 80%, making the incidence of gastropathy the same as with cyclooxygenase-2-specific inhibitors. The fact that naproxen is not associated with an increased risk of acute myocardial infarction made it an appropriate choice for this patient. (Source: Cases Journal)

An improved LC-MS/MS method for quantitative determination of ilaprazole and its metabolites in human plasma and its application to a pharmacokinetic study.

Conclusion:The validated method offered sensitivity and a wide linear concentration range. This method was successfully applied for the evaluation of the pharmacokinetics of ilaprazole and its two metabolites after single oral doses of 5 mg ilaprazole to 12 healthy Chinese volunteers.Acta Pharmacologica Sinica advance online publication, 24 August 2009; doi: 10.1038/aps.2009.120. PMID: 19701234 [PubMed - as supplied by publisher] (Source: Acta Pharmacologica Sinica)

PPI-Delayed Diagnosis of Gastrinoma: Oncologic Victim of Pharmacologic Success.

Authors: Wong H, Yau T, Chan P, Ng IO, Chan G, Hui P, Law WL, Lo CM, Hedley AJ, Epstein RJ Functional neuroendocrine tumors are often low-grade malignant neoplasms that can be cured by surgery if detected early, and such detection may in turn be accelerated by the recognition of neuropeptide hypersecretion syndromes. Uniquely, however, relief of peptic symptoms induced by hypergastrinemia is now available from acid-suppressive drugs such as proton-pump inhibitors (PPIs). Here we describe a clinical case in which time to diagnosis from the onset of peptic symptoms was delayed more than 10 years, in part reflecting symptom masking by continuous prescription of the PPI omeprazole. We propose diagnostic criteria for this under-recognized new clinical syndrome, and recommend that physicians...

Proton Pump Inhibitors to Treat GERD Cause Heartburn Problems

This study indicates unrecognized aspects of PPI withdrawal and is a very strong indication of a clinically significant acid rebound phenomenon that needs to be investigated in proper patient populations."In the randomized double-blind placebo-controlled trial, the scientists investigated whether long-term treatment with a PPI could cause a dependency state. Specifically, they wanted to see if patients would need non-stop, continuous treatment with the drugs due to rebound acid hypersecretion when the medications were stopped. In all, 120 healthy participants were randomized to about three months of taking inactive placebo pills or 40 mg. of the PPI drug esomeprazole (brand names: Nexium, Esotrex) daily. This was followed by having all the research subjects take a placebo for another four ...

Effect of soybean administration on the pharmacokinetics of carbamazepine and omeprazole in rats

Influence of soybean administration on the bioavailability of carbamazepine and omeprazole was studied after single dose administration of soybean (10 g/kg p.o.) or after chronic administration of soybean (50% w/w mixed with normal feed) for 15 days in rats. Carbamazepine was administered orally at a dose of 10 mg/kg and omeprazole at a dose of 20 mg/kg. Soybean decreased the bioavailability of carbamazepine after both single dose and chronic administration. It produced a significant decrease in Cmax, Tmax, AUC0[ndash]t of carbamazepine after single dose administration and increased the plasma clearance and Vd along with decrease in Cmax, Tmax, AUC0[ndash]t and AUC0[ndash][infin] after chronic administration. On the contrary, soybean administration increased the bioavailability of omeprazo...<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>

Omeprazole inhibits IL-4 and IL-13 signaling signal transducer and activator of transcription 6 activation and reduces lung inflammation in murine asthma

To the Editor: Proton pump inhibitors (PPIs), which are the cornerstone of gastroesophageal reflux disease therapy, have been reported to improve asthma and eosinophilic esophagitis (EE) in patients with associated gastroesophageal reflux disease symptoms. The most accepted explanation for these findings is based on the idea that pathologic acidic reflux can act as a triggering factor for these diseases through proximal extent and laryngopharyngeal reflux in asthma and impairment of the epithelial barrier in EE. Thus, it is believed that acid suppression can prevent these pathogenic mechanisms. Nonetheless, a number of findings suggested the possibility that omeprazole could have a direct effect in molecular pathways involved in asthma and EE: (1) the inhibitory mechanism of omeprazole in...

New Therapeutic Option For Heartburn

Bayer Consumer Care New Zealand will launch the OTC Proton Pump Inhibitor (PPI) omeprazole in New Zealand under the Losec¬ģ brand in September. This follows the Medicine Classification Committee's recommended approval for the Rx to OTC switch of omeprazole 10 mg, which became effective by Gazette notice on 19 March 2009. (Source: Health News from Medical News Today)

Toxic epidermal necrolysis and neutropaenia: complications of omeprazole.

Authors: Thakor AS, Burke A, Handfield-Jones S, Sinha A, Palmer M, Burns A Worldwide, proton pump inhibitors (PPI) are one of the most frequently prescribed drugs; however, up to 70% of patients taking these drugs have no appropriate indication. Although PPI are relatively well tolerated, they are not free from side-effects and several life-threatening complications are associated with them. In the present report, a 43-year-old woman presented to her general practitioner with an erythematous rash over her face and chest, having been started on omeprazole for chronic abdominal bloating. Over the next 24 h she became increasingly unwell and was admitted to hospital with shortness of breath, pyrexia and the rash spreading over her back, arms and legs. Vesicles had now started to appear wi...

Thienopyridine therapy and risk for cardiovascular events in secondary prevention

Abstract&nbsp;&nbsp;Platelets are critical modulators of atherothrombotic events. In the acute setting, platelets are activated and aggregate on the surface of atherosclerotic plaque that has ruptured, fissured, or developed erosions. The overlying thrombus leads to sudden development of arterial luminal obstruction, inducing ischemia and cellular necrosis. Inhibiting platelet reactivity is an important therapeutic goal in patients at risk for acute cardiovascular events. The thienopyridines are potent inhibitors of platelet aggregation and block the binding of adenosine 5‚?≤-diphosphate to purinergic receptors on the surface of the platelet membrane. The thienopyridine class includes ticlopidine, clopidogrel, and prasugrel. Clopidogrel is the most intensively studied. In recent year...

Hypercalcitoninemia is not pathognomonic of medullary thyroid carcinoma

Hypercalcitoninemia has frequently been reported as a marker for medullary thyroid carcinoma. Currently, calcitonin measurements are mostly useful in the evaluation of tumor size and progression, and as an index of biochemical improvement of medullary thyroid carcinomas. Although measurement of calcitonin is a highly sensitive method for the detection of medullary thyroid carcinoma, it presents a low specificity for this tumor. Several physiologic and pathologic conditions other than medullary thyroid carcinoma have been associated with increased levels of calcitonin. Several cases of thyroid nodules associated with increased values of calcitonin are not medullary thyroid carcinomas, but rather are related to other conditions, such as hypercalcemias, hypergastrinemias, neuroendocrine tumor...<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>

Coexistence of myocardial infarction with normal coronary arteries and a left circumflex artery anomaly originating from the right coronary artery with a bridge in the left anterior descending artery

Hypercalcitoninemia has frequently been reported as a marker for medullary thyroid carcinoma. Currently, calcitonin measurements are mostly useful in the evaluation of tumor size and progression, and as an index of biochemical improvement of medullary thyroid carcinomas. Although measurement of calcitonin is a highly sensitive method for the detection of medullary thyroid carcinoma, it presents a low specificity for this tumor. Several physiologic and pathologic conditions other than medullary thyroid carcinoma have been associated with increased levels of calcitonin. Several cases of thyroid nodules associated with increased values of calcitonin are not medullary thyroid carcinomas, but rather are related to other conditions, such as hypercalcemias, hypergastrinemias, neuroendocrine tumor...

Percutaneous injection of fibrin glue resolves persistent nephrocutaneous fistula complicating colonic perforation after percutaneous nephrolithotripsy

Hypercalcitoninemia has frequently been reported as a marker for medullary thyroid carcinoma. Currently, calcitonin measurements are mostly useful in the evaluation of tumor size and progression, and as an index of biochemical improvement of medullary thyroid carcinomas. Although measurement of calcitonin is a highly sensitive method for the detection of medullary thyroid carcinoma, it presents a low specificity for this tumor. Several physiologic and pathologic conditions other than medullary thyroid carcinoma have been associated with increased levels of calcitonin. Several cases of thyroid nodules associated with increased values of calcitonin are not medullary thyroid carcinomas, but rather are related to other conditions, such as hypercalcemias, hypergastrinemias, neuroendocrine tumor...

A physicochemical acid-base approach for managing diabetic ketoacidosis

Hypercalcitoninemia has frequently been reported as a marker for medullary thyroid carcinoma. Currently, calcitonin measurements are mostly useful in the evaluation of tumor size and progression, and as an index of biochemical improvement of medullary thyroid carcinomas. Although measurement of calcitonin is a highly sensitive method for the detection of medullary thyroid carcinoma, it presents a low specificity for this tumor. Several physiologic and pathologic conditions other than medullary thyroid carcinoma have been associated with increased levels of calcitonin. Several cases of thyroid nodules associated with increased values of calcitonin are not medullary thyroid carcinomas, but rather are related to other conditions, such as hypercalcemias, hypergastrinemias, neuroendocrine tumor...

Proton pump inhibitors--their pharmacological impact on the clinical management of acid-related disorders.

Authors: Klotz U Acid secretion or intragastric pH play a very important role in the pathophysiology of acid-related disorders such as peptic ulcer (PU), gastrooesophageal reflux disease (GERD) or nonsteroidal anti-inflammatory drug (NSAID)-induced gastrointestinal lesions. Proton pump inhibitors (PPIs) represent the most potent/effective antisecretory drugs for these indications. For the selection among the various agents (omeprazole/esomeprazole (CAS 73590-58-6/119141-88-7), pantoprazole (CAS 102625-70-7), lansoprazole (CAS103577-45-3), rabeprazole (CAS 117976-83-3)) some features of their pharmacokinetic (PK) and pharmacodynamic (PD) properties should be considered as the clinical outcome depends on systemic drug exposure (PK) and elevation of intragastric pH about certain threshold...

Helicobacter pylori first-line treatment and rescue option containing levofloxacin in patients allergic to penicillin

Conclusion: In H. pylori infected patients allergic to penicillin, the generally recommended first-line treatment with omeprazole, clarithromycin and metronidazole has low efficacy for curing the infection. On the other hand, a levofloxacin-containing regimen (together with omeprazole and clarithromycin) represents an encouraging second-line alternative in the presence of penicillin allergy. (Source: Digestive and Liver Disease)<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>

Toxic epidermal necrolysis and neutropaenia: Complications of omeprazole

Worldwide, proton pump inhibitors (PPI) are one of the most frequently prescribed drugs; however, up to 70% of patients taking these drugs have no appropriate indication. Although PPI are relatively well tolerated, they are not free from side-effects and several life-threatening complications are associated with them. In the present report, a 43-year-old woman presented to her general practitioner with an erythematous rash over her face and chest, having been started on omeprazole for chronic abdominal bloating. Over the next 24 h she became increasingly unwell and was admitted to hospital with shortness of breath, pyrexia and the rash spreading over her back, arms and legs. Vesicles had now started to appear within the erythematous regions over her upper body and within 24 h the rash beca...

Gastroesophageal reflux leads to esophageal cancer in a surgical model with mice

Conclusion: Surgically induced gastroesophageal reflux produced esophageal squamous cell carcinoma, but not esophageal adenocarcinoma, in mice. Dominant negative p53 mutation, heterozygous loss of INK4a/Arf, antacid treatment, iron supplementation, or gastrectomy failed to promote esophageal adenocarcinoma in these mice. Further studies are needed in order to develop a mouse model of esophageal adenocarcinoma. (Source: BMC Gastroenterology)

Lansoprazole/omeprazole: Hypomagnesaemia (first report with lansoprazole) and hypocalcaemia: 3 case reports

(Source: Reactions)

Lansoprazole/omeprazole: Hypomagnesaemia (first report with lansoprazole) and hypocalcaemia: 3 case reports.

Page: 21 (Source: Reactions Weekly)

GASTROGARD (Omeprazole) Paste [Merial Limited]

Updated Date: Jul 9, 2009 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>

[Complex metabolic disorders revealing a gastric ulcer of the bulb. A case report.]

We report the case of a 54-year-old man, without particular pathological antecedents admitted to the emergency of the university hospital of Monastir, for right renal colic. Radiography of the urinary tract without preparation and renal echography showed bilateral renal lithiasis and a right ureteral lithiasis. The interrogation revealed concept of vomiting after which the patient felt relieved. The biological assessment objectified an hypochloremic metabolic alcalosis, an increase in the anion gap, a severe impaired renal function of obstructive origin and an hypokaliemia. The presence of the lithiasis did not explain on its own the metabolic disorders of this patient. The other investigations showed that initial pathology was an evolutionary bulb ulcer into pre-stenosis justifying treatm...

Was Michael Jackson Chemically Manipulated for Profit?

(NaturalNews) Michael Jackson's death gives us an opportunity to reflect on the way he was treated by the media (and the public) while he was alive. Through his work, Michael Jackson went to great lengths to send a message of love to the world -- to inspire others and add joy to our lives -- and yet he was derided as a monster by the tabloid media while being humiliated by the comedy routines of late-night talk show hosts.Western culture is cruel to celebrities.Anyone in a position of notoriety is automatically deemed a fair target for outrageous accusations and slander. As somewhat of a minor celebrity (in a narrow field) myself, I've seen some of this cruelty directed my way, and I can only imagine how much more devastating the cruelty would be at the scale and degree that was thrust upo...

Current pharmacological management of gastro-esophageal reflux in children: an evidence-based systematic review.

Authors: Tighe MP, Afzal NA, Bevan A, Beattie RM Gastro-esophageal reflux (GER) is a common phenomenon, characterized by the regurgitation of the gastric contents into the esophagus. Gastro-esophageal reflux disease (GERD) is the term applied when GER is associated with sequelae or faltering growth. The main aims of treatment are to alleviate symptoms, promote normal growth, and prevent complications. Medical treatments for children include (i) altering the viscosity of the feeds with alginates; (ii) altering the gastric pH with antacids, histamine H(2) receptor antagonists, and proton pump inhibitors; and (iii) altering the motility of the gut with prokinetics, such as metoclopramide and domperidone. Our aim was to systematically review the evidence base for the medical treatment of g...

Relevance of metabolic activation pathways: the example of clopidogrel and prasugrel.

Authors: Petersen KU Poor or lacking responses to the antiplatelet effect of clopidogrel (CAS 113665-84-2) and the attendant clinical consequences have been a growing concern for several years. This debate has been invigorated by reports suggesting the ability of inhibitors of the cytochrome P450 isoenzyme, CYP 2C19, to interfere with clopidogrel efficacy. In the present review, the mechanisms underlying clopidogrel failure are analyzed, based on an overview of the current perceptions of drug metabolism by the CYP superfamily of enzymes, and paying particular attention to the relevant properties of the newly introduced thienopyridine, prasugrel (CAS 150322-43-3). Convincing evidence indicates that the vulnerability of clopidogrel lies in its mode of activation. In a two-step sequence, ...

Bioequivalence and pharmacokinetic study of two different omeprazole capsule formulations in healthy Bangladeshi volunteers.

Authors: Joti JJ, Nahar K, Hasan A, Azad MA, Ullah MA, Islam SM, Hasnat A Omeprazole (CAS 73590-58-6) effectively suppresses the gastric acid secretion in the parietal cells of the stomach and is a widely prescribed proton pump inhibitor in Bangladesh. The increasing number of omeprazole containing products available in the market raises questions of therapeutic equivalence and/or generic substitution which are yet to be conducted with Bangladeshi population. The aim of the study is to assess the bioequivalence and pharmacokinetic properties of two oral formulations of 20 mg omeprazole capsule, the reference product and Omep-20 as test product using serum data. The randomized, two-way crossover study was conducted on 24 healthy male subjects in compliance with the Declaration of Helsin...<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>

Control of esophageal and intragastric pH with compounded and manufactured omeprazole in patients with reflux esophagitis: a pilot study.

CONCLUSION: The omeprazole formulations studied (compounded and manufactured) showed similar control of gastric acid secretion and esophageal acid exposure in patients with reflux esophagitis. PMID: 19383986 [PubMed - indexed for MEDLINE] (Source: The Canadian Journal of Clinical Pharmacology)

Systematic review: standard- and double-dose proton pump inhibitors for the healing of severe erosive oesophagitis &#x2013; a mixed treatment comparison of randomized controlled trials

Conclusion Esomeprazole 40 mg consistently demonstrates higher healing rates compared with licensed standard- and double-dose PPIs. (Source: Alimentary Pharmacology and Therapeutics)

Effectiveness of voice therapy in reflux-related voice disorders

Gastroesophageal reflux (GER) with laryngopharyngeal reflux plays a significant role in voice disorders. A significant proportion of patients attending ear, nose, and throat clinics with voice disorders may have gastresophageal reflux disease (GERD). There is no controlled study of the effect of voice therapy on GERD. We assessed the effect of voice therapy in patients with dysphonia and GERD. Thirty-two patients with dysphonia and GERD underwent indirect laryngoscopy and voice analysis. Esophageal and laryngeal symptoms were assessed using the reflux symptom index (RSI). At endoscopy, esophagitis was graded according to Los Angeles classification. Patients were randomized to receive either voice therapy and omeprazole (20 mg bid) (n = 16, mean [SD] age 36.1 [9.6] y; 5 men; Gp A) or omepra...

Suppressive effect of sulindac on branch duct-intraductal papillary mucinous neoplasms

Conclusions&nbsp;&nbsp;Although a larger scale randomized controlled study is needed in future, the present results suggest the promise of chemoprevention of carcinoma derived from BD-IPMNs by sulindac. Content Type Journal ArticleCategory Original Article‚??Liver, Pancreas, and Biliary TractDOI 10.1007/s00535-009-0089-8Authors Tsuyoshi Hayashi, Sapporo Medical University School of Medicine Fourth Department of Internal Medicine Sapporo JapanHirotoshi Ishiwatari, Sapporo Medical University School of Medicine Fourth Department of Internal Medicine Sapporo JapanHideyuki Ihara, Sapporo Medical University School of Medicine Fourth Department of Internal Medicine Sapporo JapanYutaka Kawano, Sapporo Medical University School of Medicine Fourth Department of Internal Medicine Sapporo Ja...

A case of a gastrobronchial fistula after esophageal reconstruction successfully closed with an intercostal muscle flap

Abstract&nbsp;&nbsp;A 63-year-old man with esophageal cancer underwent a subtotal esophagectomy via the thoracolaparotomy approach. Two years after the operation, a gastrobronchial fistula unexpectedly occurred in the right bronchus. After admission, medication including omeprazole and nutritional support administered through an enteral tube improved his general condition, and the gastrobronchial fistula was successfully closed with the seventh intercostal muscle flap. After the operation, sputa were aspirated with a bronchofiberscope through a tracheal incision rather than blindly with a catheter. He was in good condition 10 months after the operation. Content Type Journal ArticleCategory Case ReportDOI 10.1007/s10388-008-0183-7Authors Hisako Kubota, Kawasaki Medical School Depa...<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>

Omeprazole Induces Gastric Permeability to Digoxin

This study reports on the potential for an omeprazole-induced leak of drugs with narrow therapeutic windows. Ussing chamber experiments investigated the effects of omeprazole on rat gastric corpus permeability to the drugs, digoxin and phenytoin. Digoxin (780&nbsp;MW) permeated the gastric mucosa at an accelerated rate in the presence of omeprazole. This leak could contribute to dangerous elevations of blood digoxin levels in certain situations. Omeprazole was found to have no effect on the flux rate of phenytoin (252&nbsp;MW). The tight-junctional leak generated by omeprazole thus exhibits specificity to the types of molecules it allows to permeate through the gastric mucosa. This leak may pose a clinical danger by increasing drug uptake into the bloodstream, a phenomenon which woul...

Dr Reddy's Labs gets USFDA nod for Omeprazole Mg OTC

Drug manufacturer Dr Reddy's Laboratories on Wednesday said it has received US regulatory approval for anti-heartburn capsules. (Source: The Economic Times Healthcare and Biotech News)

Seven-day intravenous low-dose omeprazole infusion reduces peptic ulcer rebleeding for patients with comorbidities

Conclusions: In Asian patients, prolonged low-dose omeprazole infusion for 7 days may reduce peptic ulcer rebleeding during the first 28 days in patients with comorbidities. (Source: Gastrointestinal Endoscopy)

Class Action Complaint Says Prilosec OTC Causes Food-Borne Illnesses

COLUMBUS, Ohio - A complaint filed May 29 in federal court in Ohio seeks certification of a class of persons who suffered food poisoning after taking Prilosec OTC heartburn drug (Thomas Mitchell, et al. v. Proctor & Gamble, et al., No. 09-426, S.D. Ohio, Eastern Div.). Full story on lexis.com (Source: LexisNexis&#174; Mealey's&#8482; Emerging Drugs & Devices Legal News)

The efficacy of Helicobacter pylori eradication regimen with and without vitamin C supplementation

Abstract: Background: Vitamin C in gastric juice and in vitro has been shown to inhibit the growth of Helicobacter pylori (H. pylori).Aims: The purpose of this study was to investigate the effect of addition of vitamin C to eradication regimen on H. pylori eradication rate.Patients: This randomised controlled clinical trial was conducted on 312 patients with H. pylori infection who had referred to the Taleghani Research Center of Gastroenterology and Liver Disease.Methods: Patients were randomly divided into two groups. Group A patients (162 patients) received amoxicillin 1g and metronidazole 500mg b.i.d., bismuth 240mg b.i.d. and omeprazole 40mg q.i.d. in two divided doses. Patients in group B (150 patients) received the same regimen plus 500mg vitamin C per day. All patients received the...<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>

Effect of gastric ulceration on physiologic responses to exercise in horses.

Conclusions and Clinical Relevance-In horses, gastric ulcers were induced and maintained by use of alternating periods of feeding and feed withholding in association with treadmill exercise (simulated racetrack training). Gastric ulcers adversely affected physiologic indices of performance in horses. PMID: 19496670 [PubMed - in process] (Source: American Journal of Veterinary Research)

Comparison of Outcomes Twelve Years After Antireflux Surgery or Omeprazole Maintenance Therapy for Reflux Esophagitis

Conclusions: As long-term therapeutic strategies for chronic GERD, surgery and omeprazole are effective and well-tolerated. Antireflux surgery is superior to omeprazole in controlling overall disease manifestations, but post-fundoplication complaints continue after surgery. (Source: Clinical Gastroenterology and Hepatology)

Evaluating The ADHD Medication VYVANSE CII Demonstrated No Change In Pharmacokinetic Profile Of VYVANSE When Coadministered With Prilosec OTC 40 Mg

Shire plc (LSE: SHP, NASDAQ: SHPGY), the global specialty biopharmaceutical company, announced results of a study showing that coadministration of the ADHD medication VYVANSE¬ģ (lisdexamfetamine dimesylate) CII with the proton pump inhibitor (PPI) Prilosec OTC¬ģ 40 mg (20 mg X 2), did not alte (Source: Health News from Medical News Today)

Omeprazole: Erythema following hypersensitivity to sodium laurilsulfate excipient: case report

(Source: Reactions)

Drug-Drug Interaction Between Clopidogrel and the Proton Pump Inhibitors (July/August)(CE).

CONCLUSIONS: Available data suggest that omeprazole is the PPI most likely to have a significant interaction with clopidogrel. Further studies are needed to determine that an interaction between the other PPIs and clopidogrel does not exist. In situations in which both clopidogrel and a PPI are indicated, pantoprazole should be used since it is the PPI least likely to interact with clopidogrel. PMID: 19470853 [PubMed - as supplied by publisher] (Source: The Annals of Pharmacotherapy)<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>

Efficacy of an intravenous proton pump inhibitor after endoscopic therapy with epinephrine injection for peptic ulcer bleeding in patients with uraemia: a case-control study

Conclusion Endoscopic therapy with epinephrine injection plus an intravenous proton pump inhibitor can offer protection against early re-bleeding in uraemic patients with peptic ulcer bleeding, but has a limited role beyond 7 days. (Source: Alimentary Pharmacology and Therapeutics)

No Change In Pharmacokinetics Of ADHD Medication VYVANSE CII When Coadministered With Prilosec

Shire plc (LSE: SHP, NASDAQ: SHPGY), the global specialty biopharmaceutical company, announced results of a study showing that coadministration of the ADHD medication VYVANSE¬ģ (lisdexamfetamine dimesylate) CII with the proton pump inhibitor (PPI) Prilosec OTC¬ģ 40 mg (20 mg X 2), did not alter (Source: Health News from Medical News Today)

Omeprazole: Erythema following hypersensitivity to sodium laurilsulfate excipient: case report.

Page: 31 (Source: Reactions Weekly)

Impact of Combining Proton Pump Inhibitors and Clopidogrel

Antiplatelet therapy has become the standard of care for the secondary prevention of myocardial infarction. Guidelines endorse the combined use of aspirin and clopidogrel for patients who have acute coronary syndromes or undergo percutaneous coronary intervention. The occurrence of major adverse cardiac events despite antiplatelet therapy is thought to occur because of resistance. In discussing resistance to antiplatelet therapy and a possible drug-drug interaction between clopidogrel and omeprazole, Angiolillo stated that ‚??there is no evidence that this drug-drug interaction has any clinical impact.‚?Ě However, several recent studies suggest the contrary. In 1 population-based case-control study of patients aged ‚?•66 years, the use of proton pump inhibitors in conjunction with clopidog...

Genotyping info now in US clopidogrel label

The label has been updated to include additional information on factors affecting patients' responses to the drug, including a new section on pharmacogenetics and advice that concomitant use of drugs that inhibit the CYP2C19 enzyme, such as omeprazole, should be discouraged. (Source: theHeart.org)<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>

No change in pharmacokinetics of ADHD medication VYVANSE CII when coadministered with Prilosec

This study was presented at the International Congress on Clinical Pharmacy, co-sponsored by the American College of Clinical Pharmacy. (Source: EurekAlert! - Social and Behavioral Science)

Omeprazole: Anaphylaxis: case report

(Source: Reactions)

Omeprazole: Anaphylaxis: case report.

Page: 33 (Source: Reactions Weekly)

Nexium/Prilosec Case Remanded In Wake Of Preemption Ruling

PHILADELPHIA - The Third Circuit U.S. Court of Appeals on May 5 remanded a Prilosec/Nexium consumer case after its preemption holding was reversed by the U.S. Supreme Court in Wyeth v. Diana Levine (No. 06-1249, U.S. Sup.; 2009 U.S. LEXIS 1774; See March 2009, Page 6) (Pennsylvania Employees Benefit Trust Fund, et al. v. Zeneca Inc., et al., No. 05-5340, 3rd Cir.). Full story on lexis.com (Source: LexisNexis&#174; Mealey's&#8482; Hormone Replacement Therapy Legal News)

Randomized, parallel, double-blind comparison of the ulcer-healing effects of ilaprazole and omeprazole in the treatment of gastric and duodenal ulcers

Conclusions&nbsp;&nbsp;Ilaprazole is as tolerable, safe, and efficacious as omeprazole in the treatment of gastroduodenal ulcers, at a much lower dose (5 vs. 20&nbsp;mg omeprazole). Content Type Journal ArticleCategory Original Article‚??Alimentary TractDOI 10.1007/s00535-009-0072-4Authors Khek Yu Ho, National University of Singapore Department of Medicine, Yong Loo Lin School of Medicine, National University Hospital 5 Lower Kent Ridge Road Singapore 119074 SingaporeArlene Kuan, Vicente Sotto Medical Center Cebu PhilippinesFelix Za√Īo, Philippine General Hospital Manila PhilippinesKhean Lee Goh, University Malaya Medical Centre Kuala Lumpur MalaysiaVarocha Mahachai, Chulalonkorn Hospital Bangkok ThailandDong Yeon Kim, Ilyang Central Research Institute Yongin South KoreaHwan Min ...<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>

Helicobacter pylori related dyspepsia: prevalence and treatment outcomes at University Kebangsaan Malaysia-primary care centre

Conclusions: The prevalence of dyspepsia due to HP in this primary care centre was 23.5%. Detection of HP related dyspepsia yielded good treatment outcomes (95.7%). (Source: Asia Pacific Family Medicine)

Nexium/Prilosec Case Remanded In Wake Of Preemption Ruling

PHILADELPHIA - The Third Circuit U.S. Court of Appeals on May 5 remanded a Prilosec/Nexium consumer case after its preemption holding was reversed by the U.S. Supreme Court in Wyeth v. Diana Levine (No. 06-1249, U.S. Sup.; 2009 U.S. LEXIS 1774; See 2/5/09, Page 5) (Pennsylvania Employees Benefit Trust Fund, et al. v. Zeneca Inc., et al., No. 05-5340, 3rd Cir.; See 3/19/09, Page 19). Full story on lexis.com (Source: LexisNexis&#174; Mealey's&#8482; Emerging Drugs & Devices Legal News)

Omeprazole: Anaphylaxis: 9 case reports

(Source: Reactions)

Omeprazole: Anaphylaxis: 9 case reports.

Page: 27 (Source: Reactions Weekly)

Effects of Angelicae tenuissima radix, Angelicae dahuricae radix and Scutellariae radix Extracts on Cytochrome P450 Activities in Healthy Volunteers

Abstract: Three kinds of herbal medicines, commonly used in Korea, Angelicae tenuissima radix, Angelicae dahuricae radix and Scutellariae radix were studied to evaluate their effect on cytochrome P450 (CYP) activities in healthy volunteers. A total of 24 healthy male volunteers were assigned to one of three parallel herbal treatment groups, each consisting of eight volunteers. A cocktail of probe drugs for CYP enzymes was orally administered before and after multiple administrations of herbal medicines, three times a day for 13 days. Probe drugs used to measure CYP activities were caffeine (CYP1A2), losartan (CYP2C9), omeprazole (CYP2C19), dextromethorphan (CYP2D6), chlorzoxazone (CYP2E1) and midazolam (CYP3A4). The probe drugs and their metabolites were quantified in plasma or urine using...<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>

Effects of omeprazole treatment on nucleoside transporter expression and adenosine uptake in rat gastric mucosa.

In conclusion, the possible modification of nucleoside transport activities by changes in intraluminal acidity may have significance as part of a purinergic regulatory feedback mechanism in the control of gastric acid secretion. PMID: 19448739 [PubMed - in process] (Source: Canadian Journal of Physiology and Pharmacology)

Clopidogrel inhibits CYP2C19-dependent hydroxylation of omeprazole related to CYP2C19 genetic polymorphisms.

This study explores the impact of clopidogrel on the pharmacokinetics of omeprazole related to CYP2C19 genetic polymorphisms. Twelve healthy volunteers (6 CYP2C19*1/*1, 5 CYP2C19*2/*2, and 1 CYP2C19*2/*3) are enrolled in a 2-phase randomized crossover trial. In each phase, the volunteers are administered a single oral dose of omeprazole 40 mg after pretreatment of either placebo or clopidogrel (300 mg on the first day and then 75 mg once daily for 3 consecutive days). Plasma concentrations of omeprazole and its metabolites are quantified by high-performance liquid chromatography with UV detection. After clopidogrel treatment, the AUC(0-infinity) of omeprazole increases by 30.02% +/- 18.03% (P = .004) and that of 5-hydroxyomeprazole decreases by 24.30% +/- 11.66% (P = .032) in CYP2C19*1/*1....

Clinical use of pharmacogenomic tests in 2009.

This article briefly reviews the evidence for the utilisation of pharmacogenomics for antidepressant drugs, tamoxifen, codeine, warfarin, azathioprine, clopidogrel, omeprazole, tacrolimus and irinotecan. There are few pharmacogenomics tests being carried out in practice, as there has not been a wide appreciation of their use, and only limited evidence exists for many individual drugs. It is expected that utilisation will increase as more evidence becomes available and there is a wider understanding of the existing evidence by the medical profession. PMID: 19565025 [PubMed - in process] (Source: The Clinical Biochemist. Reviews)

Deciding whether to abandon an acid blocker

Harvard Medical College I have asthma and acid reflux. My asthma only flares up occasionally, and I rarely get heartburn. I've been taking over-the-counter Prilosec every day for the past three years. I read that people with asthma don't need acid... (Source: OrlandoSentinel: Medical Research)

Proton pump inhibitors as a treatment method for type II diabetes

We examined our electronic database to obtain glycohemoglobin (HgbA1c) levels measured in the past two years from all type II diabetics and extracted from those diabetics who were concurrently taking a proton pump inhibitor. A comparison of these groups showed an average HgbA1c of 7.6% for type II diabetics not taking a proton pump inhibitor (n=282) and an average HgbA1c of 7.0% for type II diabetics concurrently taking a proton pump inhibitor (n=65), T=‚??3.61, p=0.002. These data support the hypothesis that proton pump inhibitors can be used to treat type II diabetes. (Source: Medical Hypotheses)

Effect of the Cytochrome P450 2C19 Inhibitor Omeprazole on the Pharmacokinetics and Safety Profile of Bortezomib in Patients with Advanced Solid Tumours, Non-Hodgkins Lymphoma or Multiple Myeloma

(Source: Clinical Pharmacokinetics)

Platelet-Function Test Finds Fault With Omeprazole/Clopidogrel Combo, but Not With Other PPIs

Platelet aggregation was significantly higher in patients taking omeprazole than in patients not taking a PPI or in patients taking pantoprazole or esomeprazole. Heartwire (Source: Medscape Medical News Headlines)

Platelet-function test finds fault with omeprazole/clopidogrel combo, but not with other PPIs

Platelet aggregation was significantly higher in patients taking omeprazole than in patients not taking a PPI or in patients taking pantoprazole or esomeprazole. (Source: theHeart.org)

Simultaneous estimation of four proton pump inhibitors-lansoprazole, omeprazole, pantoprazole and rabeprazole: development of a novel generic HPLC-UV method and its application to clinical pharmacokinetic study.

Authors: Bharathi DV, Hotha KK, Jagadeesh B, Chatki PK, Thriveni K, Mullangi R, Naidu A A highly selective, sensitive and accurate HPLC method has been developed and validated for the estimation of four proton-pump inhibitors (PPI), lansoprazole (LPZ), omeprazole (OPZ), pantoprazole (PPZ) and rabeprazole (RPZ), with 500 microL human plasma using zonisamide as an internal standard (IS). The sample preparation involved simple liquid-liquid extraction of LPZ, OPZ, PPZ and RPZ and IS from human plasma with ethyl acetate. The baseline separation of all the peaks was achieved with 0.1% triethylamine (pH 6.0):acetonitrile (72:28, v/v) at a flow rate of 1 mL/min on a Zorbax C(8) column. The total chromatographic run time was 11.0 min and the simultaneous elution of IS, OPZ, RPZ, PPZ and LPZ oc...<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>

Effects of preoperative administration of omeprazole on bleeding after endoscopic submucosal dissection: a prospective randomized controlled trial

Endoscopy 2009; 41: 299-303DOI: 10.1055/s-0029-1214530 The effectiveness of preoperative administration of proton pump inhibitors (PPIs) for the prevention of bleeding after endoscopic submucosal dissection (ESD) is unclear. Our aim was to evaluate the benefit of starting PPI treatment 1 day before ESD to prevent bleeding after the procedure.[...]© Georg Thieme Verlag KG Stuttgart · New YorkGet connected:Table of contents  |  Abstract  |  Full text (Source: Endoscopy)

Santarus Announces FDA Acceptance Of New Drug Application For ZEGERID Tablet Product

Santarus, Inc. (NASDAQ:SNTS), a specialty pharmaceutical company, announced that the U.S. Food and Drug Administration (FDA) has accepted for filing the company's New Drug Application (NDA) for a new tablet formulation to add to its ZEGERID¬ģ family of branded prescription pharmaceutical products. Pursuant to Prescription Drug User Fee Act (PDUFA) guidelines, Santarus expects the FDA will complete its review or otherwise respond to the NDA by December 4, 2009. (Source: GastroIntestinal News From Medical News Today)

A Cause of Dysphagia That Is Difficult to Swallow

A 16-year-old girl with a past medical history of Nissen fundoplication as an infant presented with intermittent dysphagia and sharp chest pain that radiated to her left shoulder while swallowing for 3 months. Omeprazole partially relieved her symptoms. Review of upper endoscopy performed at another facility showed a bulge in the lower esophagus, without any mucosal break, suggestive of a subepithelial lesion. As her symptoms became persistent, she presented 2 weeks later to our institution's emergency room. Computed tomography () and repeat endoscopy () were performed. Teflon pledgets (Dupont, Wilmington, DE) with attached suture from prior fundoplication were removed during endoscopy using the rat-tooth forceps (). Her symptoms improved 3 days after the endoscopy and were resolved comple...

Use of gastrointestinal proton pump inhibitors to regulate osteoclast-mediated resorption of calcium phosphate cements in vivo.

Authors: Sheraly AR, Lickorish D, Sarraf F, Davies JE Osteoclasts degrade bone through the creation of an enclosed, acidic extracellular microenvironment adjacent to the bone surface. Membrane bound proton pumps in the osteoclast cell membrane function to create this acidified environment. Accordingly, this H(+) ion transport mechanism provides a potential target for a specific class of drugs, proton pump inhibitors (PPI), with a view to controlling osteoclast mediated bone resorption. Self setting calcium phosphate cements are common bone graft materials that are degraded by osteoclastic activity. We have already shown that incorporation of bafilomycin, a non-regulated PPI, within these cements prevents or delays osteoclast mediated resorption of the cement. We demonstrate here that t...

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