TEMAZEPAM Capsule [American Health Packaging]

Updated Date: Feb 10, 2014 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

TEMAZEPAM Capsule [Mallinckrodt, Inc.]

Updated Date: Feb 10, 2014 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

TEMAZEPAM Capsule [McKesson Packaging Services A Business Unit Of McKesson Corporation]

Updated Date: Feb 6, 2014 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

National Use of Prescription Medications for Insomnia: NHANES 1999-2010

Conclusion:In this nationally representative sample, reported use of prescription medications commonly used for insomnia (MCUFIs) within the preceding month was common, particularly among older adults and those seeing a mental health provider, with high use of sedative polypharmacy among MCUFI users.Citation:Bertisch SM; Herzig SJ; Winkelman JW; Buettner C. National use of prescription medications for insomnia: NHANES 1999-2010. SLEEP 2014;37(2):343-349. (Source: Sleep)

Association Between Potentially Inappropriate Medications From the Beers Criteria and the Risk of Unplanned Hospitalization in Elderly Patients.

CONCLUSIONS: Due caution prescribing Beers medications in the elderly seems justified, paying particular attention to PIMs listed above and to the concurrent use of multiple PIMs. Our results also support the retention of specific medications on PIM lists in future developments. PMID: 24396090 [PubMed - as supplied by publisher] (Source: The Annals of Pharmacotherapy)<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>

Direct determination of diazepam and its glucuronide metabolites in human whole blood by μElution solid-phase extraction and liquid chromatographyâ??tandem mass spectrometry

Abstract: A μElution solid-phase extraction (SPE) liquid chromatographyâ??tandem mass spectrometry (LCâ??MS/MS) method for simultaneous determination of diazepam, nordiazepam, oxazepam, oxazepam glucuronide, temazepam and temazepam glucuronide in human whole blood is presented. 200μL of whole blood samples were loaded onto a Waters Oasis HLB 96-well μElution SPE plate using 75μL of methanol as the elution solvent, and the eluents were injected into an Eclipse XDB C18 column. No hydrolysis, solvent transfer, evaporation or reconstitution was involved in the sample preparation procedures. Tandem mass spectrometric detection with Turbo Ion Spray was conducted via multiple reaction monitoring (MRM) under positive ionization mode. The method was validated and proved to be accurate (accuracy...

Melatonin for sedative withdrawal in older patients with primary insomnia: A randomised double�blind placebo�controlled trial

ConclusionsGradual dose reduction of BZD combined with CRM or placebo, and psychosocial support produced high short�term and moderate long�term BZD abstinence. CRM showed no withdrawal benefit compared to placebo (Source: British Journal of Clinical Pharmacology)

The association of anticonvulsant use with fractures in spinal cord injury.

CONCLUSIONS: Attention to fracture prevention is important when anticonvulsants are prescribed in spinal cord injury, particularly when more than one anticonvulsant is used. PMID: 24252933 [PubMed - in process] (Source: Medical Physics)

Twenty�year trends in benzodiazepine dispensing in the Australian population

ConclusionDespite a modest overall decline in the amount of benzodiazepine dispensed, the level of use is still likely to reflect relative over�prescribing given the paucity of accepted indications for long�term use. Since 1998 there was a polynomial increase in quantity dispensed per script. The WHO defined DDD for clonazepam seems inappropriate and could impede monitoring of its abuse. Other problems include lack of national data for medications not subsidised on PBS/RPBS. A broad policy approach is required, not one which targets only one particular benzodiazepine.Keywords: Benzodiazepine, Anxiolytic drugs, hypnotics, sedatives, defined daily dose, Ashton equivalent dose (Source: Internal Medicine Journal)

A Randomized Trial of Temazepam versus Acetazolamide in High Altitude Sleep Disturbance

High Altitude Medicine & Biology , Vol. 0, No. 0. (Source: High Altitude Medicine)<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>

Diazepam and its metabolites in the mothers' and newborns' hair as a biomarker of prenatal exposure.

Authors: Senczuk-Przybylowska M, Florek E, Piekoszewski W, Merritt TA, Lechowicz E, Mazela J, Kulza M, Breborowicz GH, Krzyscin M, Markwitz W, Miechowicz I Abstract Pregnant women are exposed to benzodiazepines for therapeutic purposes during gestation. The goal of this study was to evaluate prenatal exposure to benzodiazepines. Time of exposure during course of pregnancy is a significant aspect of fetal exposure to drugs. Benzodiazepine concentration assay in hair of mothers and newborns exposed prenatally to these drugs was performed in the studies. Development, validation and evaluation of benzodiazepine determination method in mothers and their newborns enables assessment of health risks for the child and implementation of adequate therapeutic procedures. We used A LC-ESI-MS/MS...

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