TIZANIDINE Tablet [Mylan Pharmaceuticals Inc.]

Updated Date: Jan 13, 2014 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

TIZANIDINE Tablet [Apotex Corp.]

Updated Date: Jan 9, 2014 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

TIZANIDINE Tablet [New Horizon Rx Group, LLC]

Updated Date: Dec 30, 2013 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

TIZANIDINE Tablet [Clinical Solutions Wholesale]

Updated Date: Dec 16, 2013 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

Non-antiepileptic drugs for trigeminal neuralgia.

CONCLUSIONS: There is low-quality evidence that the effect of tizanidine is not significantly different than that of carbamazepine in treating trigeminal neuralgia. Pimozide is more effective than carbamazepine, although the evidence is of low quality and the data did not allow comparison of adverse event rates. There is also low-quality evidence that 0.5% proparacaine hydrochloride eye drops have no benefit over placebo. Limitations in the data for tocainide prevent any conclusions being drawn. There is insufficient evidence from randomised controlled trials to show significant benefit from non-antiepileptic drugs in trigeminal neuralgia. More research is needed. PMID: 24297506 [PubMed - as supplied by publisher] (Source: Cochrane Database of Systematic Reviews)<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>

The effect of antispastic drugs on motor reflexes and voluntary muscle contraction in incomplete spinal cord injury.

CONCLUSIONS: These results suggest that antispastic agents are effective in reducing stretch reflexes without substantially reducing volitional torque. Differential effects of tizanidine and baclofen on reflexes of flexors and extensors warrant further investigation into patient-specific management of antispastic medications. PMID: 24269485 [PubMed - as supplied by publisher] (Source: Physica Medica)

Amitriptyline versus tizanidine in the management of tension‚?źtype headache in Nepal

(Source: Emergency Medicine Australasia)

Clonidine and other central alpha-2 agonists: can one pill kill a toddler?

3 out of 5 stars Unintentional Pediatric Exposures to Central Alpha-2 Agonists Reported to the National Poison Data System. Wang GS et al.¬†J Pediatr 2013 Oc 1 [Epub ahead of print] Abstract Central alpha-2 agonists ‚?? clonidine, guanfacine, and tizanidine ‚?? are increasingly being used for approved and off-label indications, including hypertension, muscle spasms, tics, and opioid withdrawal. Extended-release forms of guanfacine (Intuniv) and clonidine (Kapvay) have been approved for treatment of attention-deficit hyperactivity disorder (ADHD). These drugs are selective agonists at the central presynaptic alpha-2 adrenergic receptors. They decrease catecholamine release and sympathetic tone. Adverse effects include CNS depression, bradycardia, and hypotension. Some chapters and review ar...

Use of Intrathecal Baclofen for Treatment of Severe Spasticity in Selected Patients With Motor Neuron Disease

Conclusions. Our findings suggest that ITB can effectively reduce spasticity and related symptoms without compromising function in selected patients with U-MND. (Source: Neurorehabilitation and Neural Repair)

Unintentional Pediatric Exposures to Central Alpha-2 Agonists Reported to the National Poison Data System

Conclusions: The number of unintentional pediatric exposures to alpha-2 agonists increased from 2000-2011. Clonidine exposures were the most commonly reported, more symptomatic, and associated with 3 deaths. Despite central nervous system depression, bradycardia, and hypotension being common, the need for intubation and vasopressors was rare. (Source: The Journal of Pediatrics)<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>

Adherence Associated With Oral Medications in the Treatment of Spasticity

Objective: To examine adherence to baclofen, tizanidine, and dantrolene (U.S. Food and Drug Administration‚??approved oral spasticity medications), and identified determinants of adherence.Design: A retrospective administrative claims data analysis that used medical and pharmacy claims data and enrollment information from a large, national U.S. health plan.Subjects and Methods: The subjects were commercial health plan members who initiated treatment on baclofen, tizanidine, or dantrolene from January 1, 2004, through September 30, 2009, and who had stroke, spinal cord injury, traumatic brain injury, cerebral palsy, or multiple sclerosis. Descriptive and logistic regression statistical analyses were performed.Main Outcome Measurements: Outcomes were adherence, measured as continuous medicat...

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