Nucynta Serotonin Syndrome Side Effect Reports


The following Nucynta Serotonin Syndrome side effect reports were submitted by healthcare professionals and consumers.

This information will help you understand how side effects, such as Serotonin Syndrome, can occur, and what you can do about them.

A side effect could appear soon after you start Nucynta or it might take time to develop.


Akathisia, Torticollis, Grimacing, Dyskinesia, Dystonia, Fibromyalgia, Serotonin Syndrome, Hyperthermia, Hypertension

This Serotonin Syndrome side effect was reported by a health professional from US. A 59-year-old female patient (weight:NA) experienced the following symptoms/conditions: pain. The patient was prescribed Nucynta (dosage: NA), which was started on Sep 22, 2013. Concurrently used drugs:
  • Sertraline
  • Duloxetine
  • Doxepin
  • Cyclobenzaprine
When starting to take Nucynta the consumer reported the following symptoms:
  • Akathisia
  • Torticollis
  • Grimacing
  • Dyskinesia
  • Dystonia
  • Fibromyalgia
  • Serotonin Syndrome
  • Hyperthermia
  • Hypertension
The patient was hospitalized. These side effects may potentially be related to Nucynta.
Intentional Overdose, Hypertension, Suicide Attempt, Serotonin Syndrome, Depressed Level Of Consciousness, Respiratory Depression, Lethargy, Miosis, Nystagmus

This Serotonin Syndrome Nucynta Er side effect was reported by a health professional from US on Oct 16, 2013. A Female , 18 years of age, was treated with Nucynta Er. The patient presented the following health conditions:
  • Intentional Overdose
  • Hypertension
  • Suicide Attempt
  • Serotonin Syndrome
  • Depressed Level Of Consciousness
  • Respiratory Depression
  • Lethargy
  • Miosis
  • Nystagmus
. Nucynta Er dosage: NA. Additional drugs used at the same time:
  • Acetaminophen
The patient was hospitalized.
Serotonin Syndrome, Vertigo

This is a Nucynta Ir side effect report of a 28-year-old patient (weight:NA) from US, suffering from the following symptoms/conditions: pain, who was treated with Nucynta Ir (dosage:Thrice A Day, start time: Apr 22, 2013), combined with:
  • Cymbalta (60 Mg + 30 Mg, Once Daily)
  • Cymbalta (60 Mg + 30 Mg, Once Daily)
  • Cymbalta (60 Mg + 30 Mg, Once Daily)
, and developed a serious reaction and a Serotonin Syndrome side effect. The patient presented with:
  • Serotonin Syndrome
  • Vertigo
which developed after the beginning of treatment. The patient was hospitalized. This side effect report can indicate a possible existence of increased vulnerability to Nucynta Ir treatment in patients suffering from pain, resulting in Serotonin Syndrome.
Serotonin Syndrome, Tremor, Anxiety, Sedation, Chills, Diarrhoea, Headache, Therapeutic Response Decreased

A 39-year-old patient (weight: NA) from US with the following symptoms: back pain started Nucynta Er treatment (dosage: 100mg Bid Po) on Dec 21, 2012. Soon after starting Nucynta Er treatment, the consumer experienced several side effects, including:
  • Serotonin Syndrome
  • Tremor
  • Anxiety
  • Sedation
  • Chills
  • Diarrhoea
  • Headache
  • Therapeutic Response Decreased
. Concurrently used drugs: NA.The patient was hospitalized. This finding indicates that some patients can be more vulnerable to developing Nucynta Er side effects, such as Serotonin Syndrome.
Serotonin Syndrome, Feeling Jittery, Anxiety, Treatment Noncompliance

A female patient from US was prescribed and started Nucynta Ir on Mar 15, 2013. Patient felt the following Nucynta side effects: serotonin syndrome, feeling jittery, anxiety, treatment noncompliance Additional patient health information: Female , 62 years of age, The consumer reported the following symptoms: was diagnosed with and. Nucynta Ir dosage: 1-2 Tablets Every 4-6 Hours As Needed. Concurrently used drugs:
  • Cymbalta
The patient was hospitalized.
Serotonin Syndrome

This report suggests a potential Nucynta Ir Serotonin Syndrome side effect(s) that can have serious consequences. A 61-year-old patient from US (weight:NA) was diagnosed with the following health condition(s): pain and used Nucynta Ir (dosage: Every 4-6 Hour Via Tube) starting Aug 13, 2012. Soon after starting Nucynta Ir the patient began experiencing various side effects, including:
  • Serotonin Syndrome
Drugs used concurrently:
  • Fentanyl (Every 72 Hour)
  • Celexa (Daily Via Tube)
  • Citalopram
  • Trazodone (Via Tube Every Every Night At Bedtime Since Years)
  • Savella
  • Hydrochlorothiazide
  • Prevacid
  • Lopressor (Twice Daily Via Tube)
Although Nucynta Ir demonstrated significant improvements in a number of clinically relevant cases, troublesome symptoms, such as Serotonin Syndrome, may still occur.
Serotonin Syndrome

An adverse event was reported by a health professional on Oct 19, 2012 by a Female taking Nucynta Er (dosage: Twice Daily) was diagnosed with and. Location: US , 48 years of age, patient began experiencing various side effects, including: Directly after treatment started, patient experienced the unwanted or unexpected Nucynta side effects: serotonin syndrome. Additional medications/treatments:
Overdose, Serotonin Syndrome, Depressed Level Of Consciousness, Confusional State, Delirium, Convulsion, Blood Creatine Phosphokinase Increased

This Serotonin Syndrome problem was reported by a physician from CA. A female patient (weight: NA) was diagnosed with the following medical condition(s): headache.On Jun 15, 2012 a consumer started treatment with Nucynta Cr (dosage: 1 Tablet 2 Times A Day For 7x10 Days With A Provision For 50 Mg Bid Titration Every 5 Days). The following drugs/medications were being taken at the same time: NA. When commencing Nucynta Cr, the patient experienced the following unwanted symptoms /side effects:
  • Overdose
  • Serotonin Syndrome
  • Depressed Level Of Consciousness
  • Confusional State
  • Delirium
  • Convulsion
  • Blood Creatine Phosphokinase Increased
The patient was hospitalized. Although all drugs are carefully tested before they are licensed for use, they carry potential side effect risks. Some side effects, such as Serotonin Syndrome, may become evident only after a product is in use by the general population.
Withdrawal Syndrome, Serotonin Syndrome

This is a Nucynta Er side effect report of a patient (weight: NA) from UNITED STATES. The patient developed the following symptoms/conditions: back pain and was treated with Nucynta Er (dosage: Twice A Day) starting Feb 22, 2012. Concurrently used drugs: NA. Soon after that, the consumer experienced the following of symptoms:
  • Withdrawal Syndrome
  • Serotonin Syndrome
This opens a possibility that Nucynta Er could cause Serotonin Syndrome and that some patients may be more susceptible.
Withdrawal Syndrome, Serotonin Syndrome

This Serotonin Syndrome side effect was reported by a consumer or non-health professional from UNITED STATES on Mar 27, 2012. A patient from UNITED STATES , weighting 198.0 lb, was diagnosed with and was treated with Nucynta Er. Directly after treatment started, patient experienced the unwanted or unexpected Nucynta side effects: withdrawal syndrome, serotonin syndrome. Nucynta Er dosage: Twice A Day. These side effects may potentially be related to Nucynta Er.
Paraesthesia, Blood Pressure Increased, Toxicity To Various Agents, Serotonin Syndrome

This Serotonin Syndrome side effect was reported by a health professional from UNITED STATES. A 55-year-old female patient (weight:NA) experienced the following symptoms/conditions: pain. The patient was prescribed Nucynta (dosage: Every 4-6 Hours), which was started on NS. Concurrently used drugs:
  • Tobradex
  • Fluticasone
  • Clonidine
  • Paroxetine Hcl (Once Daily)
  • Ranitidine
  • Cytomel
When starting to take Nucynta the consumer reported the following symptoms:
  • Paraesthesia
  • Blood Pressure Increased
  • Toxicity To Various Agents
  • Serotonin Syndrome
The patient was hospitalized and became disabled. These side effects may potentially be related to Nucynta.
Serotonin Syndrome, Withdrawal Syndrome

This Serotonin Syndrome Nucynta Er side effect was reported by a consumer or non-health professional from UNITED STATES on Mar 09, 2012. A male , weighting 190.0 lb, was diagnosed with and was treated with Nucynta Er. The patient presented the following health conditions:
  • Serotonin Syndrome
  • Withdrawal Syndrome
. Nucynta Er dosage: Twice A Day. Additional drugs used at the same time: NA.
Ataxia, Disorientation, Dysarthria, Akathisia, Serotonin Syndrome, Aggression, Speech Disorder, Abnormal Behaviour

This is a Nucynta side effect report of a 63-year-old patient (weight:NA) from US, suffering from the following symptoms/conditions: procedural pain, who was treated with Nucynta (dosage:Once Every 6 Hours Prn (only 15o Mg Tablet Taken), start time: Jun 15, 2011), combined with: NA., and developed a serious reaction and a Serotonin Syndrome side effect. The patient presented with:
  • Ataxia
  • Disorientation
  • Dysarthria
  • Akathisia
  • Serotonin Syndrome
  • Aggression
  • Speech Disorder
  • Abnormal Behaviour
which developed after the beginning of treatment. The patient was hospitalized. This side effect report can indicate a possible existence of increased vulnerability to Nucynta treatment in patients suffering from procedural pain, resulting in Serotonin Syndrome.
Serotonin Syndrome, Withdrawal Syndrome

A patient (weight: NA) from UNITED STATES with the following symptoms: back pain,intervertebral disc protrusion started Nucynta Er treatment (dosage: Twice A Day) on Feb 22, 2012. Soon after starting Nucynta Er treatment, the consumer experienced several side effects, including:
  • Serotonin Syndrome
  • Withdrawal Syndrome
. Concurrently used drugs:
  • Duragesic-100 (1 In 72hrs)
  • Duragesic-100 (1 In 72hrs)
This finding indicates that some patients can be more vulnerable to developing Nucynta Er side effects, such as Serotonin Syndrome.
Feeling Drunk, Incorrect Dose Administered, Serotonin Syndrome, Pain

A patient from UNITED STATES was prescribed and started Nucynta Er on Jan 25, 2012. After Nucynta was administered, patient encountered several Nucynta side effects: feeling drunk, incorrect dose administered, serotonin syndrome, pain Additional patient health information: male , 70 years of age, The consumer reported the following symptoms: was diagnosed with and. Nucynta Er dosage: NA. Concurrently used drugs: NA. The patient was hospitalized.
Balance Disorder, Serotonin Syndrome, Disorientation, Akathisia, Dysarthria, Aggression

This report suggests a potential Nucynta Serotonin Syndrome side effect(s) that can have serious consequences. A patient from UNITED STATES (weight:NA) was diagnosed with the following health condition(s): procedural pain and used Nucynta (dosage: Once Every 6 Hours Prn (only 15o Mg Tablet Taken)) starting Jun 15, 2011. Soon after starting Nucynta the patient began experiencing various side effects, including:
  • Balance Disorder
  • Serotonin Syndrome
  • Disorientation
  • Akathisia
  • Dysarthria
  • Aggression
Drugs used concurrently:NA. The patient was hospitalized. Although Nucynta demonstrated significant improvements in a number of clinically relevant cases, troublesome symptoms, such as Serotonin Syndrome, may still occur.
Balance Disorder, Aggression, Dysarthria, Akathisia, Disorientation, Serotonin Syndrome

An adverse event was reported by a health professional on Dec 01, 2011 by a male taking Nucynta (dosage: Once Every 6 Hours Prn (only 15o Mg Tablet Taken)) was diagnosed with and. Location: UNITED STATES , weighting 210.0 lb, patient began experiencing various side effects, including: Patient felt the following Nucynta side effects: balance disorder, aggression, dysarthria, akathisia, disorientation, serotonin syndrome. Additional medications/treatments: The patient was hospitalized.
Balance Disorder, Aggression, Serotonin Syndrome, Disorientation, Dysarthria, Akathisia

This Serotonin Syndrome problem was reported by a health professional from UNITED STATES. A patient (weight: NA) was diagnosed with the following medical condition(s): procedural pain.On Jun 15, 2011 a consumer started treatment with Nucynta (dosage: Once Every 6 Hours Prn (only 15o Mg Tablet Taken)). The following drugs/medications were being taken at the same time: NA. When commencing Nucynta, the patient experienced the following unwanted symptoms /side effects:
  • Balance Disorder
  • Aggression
  • Serotonin Syndrome
  • Disorientation
  • Dysarthria
  • Akathisia
The patient was hospitalized. Although all drugs are carefully tested before they are licensed for use, they carry potential side effect risks. Some side effects, such as Serotonin Syndrome, may become evident only after a product is in use by the general population.
Aggression, Disorientation, Akathisia, Balance Disorder, Serotonin Syndrome, Dysarthria

This is a Nucynta side effect report of a 63-year-old patient (weight: NA) from UNITED STATES. The patient developed the following symptoms/conditions: procedural pain and was treated with Nucynta (dosage: Once Every 6 Hours Prn) starting Jun 15, 2011. Concurrently used drugs: NA. Soon after that, the consumer experienced the following of symptoms:
  • Aggression
  • Disorientation
  • Akathisia
  • Balance Disorder
  • Serotonin Syndrome
  • Dysarthria
The patient was hospitalized. This opens a possibility that Nucynta could cause Serotonin Syndrome and that some patients may be more susceptible.
Serotonin Syndrome, Myalgia, Rhabdomyolysis, Fatigue, Chromaturia

This Serotonin Syndrome side effect was reported by a health professional from UNITED STATES on Sep 06, 2011. A female patient from UNITED STATES , 34 years of age, weighting 140.0 lb, was diagnosed with and was treated with Nucynta. Patient felt the following Nucynta side effects: serotonin syndrome, myalgia, rhabdomyolysis, fatigue, chromaturia. Nucynta dosage: 75mg. The patient was hospitalized. These side effects may potentially be related to Nucynta.

DISCLAIMER: ALL DATA PROVIDED AS-IS, refer to terms of use for additional information.

Nucynta Serotonin Syndrome Causes and Reviews


Antidepressants are medicines that treat depression. Your doctor can prescribe them for you. They work to balance some of the natural chemicals in our brains. It may take several weeks for them to help. There are several types of antidepressants. You and your doctor may have to try a few before finding what works best for you.

Antidepressants may cause mild side effects that usually do not last long. These may include headache, nausea, sleep problems, restlessness, and sexual problems. Tell your doctor if you have any side effects. You should also let your doctor know if you take any other medicines, vitamins, or herbal supplements.

It is important to keep taking your medicines, even if you feel better. Do not stop taking your medicines without talking to your doctor. You often need to stop antidepressants gradually.

NIH: National Institute of Mental Health


Nucynta Serotonin Syndrome Reviews

Wed, 22 Feb 2012

Taking any medications with
serotonin? If you are, Nucynta ER can cause
life-threatening Serotonin Syndrome if you are taking any other serotonergic
drugs (Prozac, Effexor etc.). On January 18, 2012 I found my husband unconscious in our car, the
car’s emergency lights were flashing, fortunately the car was not on and the
garage door was open. I rushed him to the Emergency Room of, a major NJ medical
facility; he remained in the emergency room for 13 hours. He was then moved to a
room on the cardiac floor so he could be closely monitored for several more
days.

After extensive testing and examination, I
was told he had been in renal failure. Further, x-rays indicated he might have pneumonia
or he might have ingested something in his lungs as he passed out in his car.
He also had very low oxygen levels in his blood. He had hallucinations, as I
watched, barely aware of his surroundings. His Internist, Neurologist, and
Pulmonary specialists, all confirmed the diagnosis of “Serotonin Syndrome", a
life threatening condition. They agreed the cause appeared to be the addition
of Nucynta ER without elimination of the other medications with serotonin,
medications he had been taking for the past 4-5 years with no ill effects.

DISCLAIMER: ALL DATA PROVIDED AS-IS, refer to terms of use for additional information.

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Serotonin Syndrome (30)
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