Debacterol Canker Sore Pain Relief solution is a liquid topical agent that is used in the treatment of ulcerating oral mucosal lesions and minor oral abrasions.[1] Debacterol is used[2] in the treatment of recurrent aphthous stomatitis (canker sores). Debacterol usually comes in a swab form, but is also available in a vial. Debacterol is not listed in the Physician's Desk Reference comprehensive list of prescription drugs[3]. Debacterol has not been tested or been proven to be safe and effective by the Food and Drug Administration[4]. Debacterol is not an antiseptic or anesthetic topical agent. It is a mixture of powerful acids that function as a chemical cautery to destroy all cells at the application site, including the nerve endings that transmit pain. One clinical trial comparing Debacterol to Kenalog-in-Orabase and a no-intervention control group found that patients treated with Debacterol reported significantly better relief of symptoms compared to the other two groups 3 days after treatment.[5] In the same study, 60% of ulcers treated with Debacterol had disappeared by day 6 compared to about 30% in the other groups.[5] Debacterol appears to be more effective on mouth sores in areas of the mouth which have less saliva production. Since a mouth sore must be dry prior to application of Debacterol, the area under the tongue is difficult to get a solid application on. The length of time of pain relief and the overall effectiveness may be reduced in areas such as this.