Malaise is a feeling of general discomfort, uneasiness, or pain, often the first sign of an infection or other disease.[1][2] The word has existed in the French language since at least the 12th century. The term is also often used figuratively in other contexts. Malaise is a non-specific symptom and can be present in the slightest ailment, such as an emotion (causing fainting, a vasovagal response) or hunger (light hypoglycemia[3]), to the most serious conditions (cancer, stroke, heart attack, internal bleeding, etc.). Malaise expresses a patient's uneasiness that "something is not right" that may need a medical examination to determine the significance. Malaise is thought to be caused by the activation of an immune response, and the associated pro-inflammatory cytokines.[4] "Economic Malaise" refers to an economy that is stagnant or in recession (compare depression). The term is particularly associated with the US 1973–75 recession.[5] A speech made by President Jimmy Carter in 1979 is commonly referred to as the "Malaise" speech, although the term was not in the speech.[6]