I'm 50 years old, and recently my regular menstrual cycles have stopped. After usual diagnostic procedure, the gynegologist and the endocrinologist strongly advised me to start Activelle. Apart from the shorter vaginal bleeding on the day 14th, in the third week of the therapy a modest but tolerable anxiety was persisting the whole week. However, on the day 24th following the start of the therapy I experienced a sudden and intensive panic attack which was solved by 5 mg of diazepam p.o. I have never had similar emotional problems before. Specialists adviced me not to stop the therapy. In the following day or two I felt better already.