I'm using it and my knee has shown at least 90 percent improvement, and only 2 months ago they wanted to do a full knee replacement. I am 65 years old,female,have hada very active life style and am relieved that this medication has helped and worked. Ialso suffer with D.I.S.H. and it seemsto helpwith the movement. On the negative side, both my eyes twitch andit is difficult to read and use my keyboard but Ipersist.