I just read Jennifer Connelly's post about her experience with Deplin.I've been diagnosed with major depressive disorder and bi-polar. I had been seeing a county provided psychologist who kept trying different anti psychotropic drugs I had bad reactions to the 7 different drugs they tried within a 6 month period.My reactions to these drugs were the same as Jennifer describes with her use of Deplin. I thought I was insane and I would never get my sanity back again. I was also seeing a neurologist for physical problems. My neurologist did a lot of tests, my blood work showed I was low in Folic acid. My brain MRI showed I had a lesion on it deep inside. My neurologist prescribed Deplin, suggested I find a new psychologist,stop taking antipsychotics and the Abilify I was on (with bad reactions to that medication too), switched my Celexa to Lexapro(at my request,I had better results with Lexapro). It is now 3 months later, I'm no longer depressed even with chronic pain. I was able to reduce my Xanax from 3 times daily to 1 time daily. I am taking myself off the Lexapro because I want to be on less medications ( will go back on it if I begin to have a problem with depression again). I no longer need a mood stabilizer for my bi-polar. My friends are telling me I'm "normal again", " the old Pam is back" and I agree with them. I thank God for Deplin. I started to research Deplin on the Internet after I noticed an improvement in my mental illnesses. I found out that Deplin goes straight to the brain and works on the Serotonin,Norepinephrine and Dopamine. My neurologist prescribed it for the brain lesion and it also has helped my depression and bi-polar. What a great discovery!!! I can not say enough good about Deplin, it has completely turned my world around in a wonderfully good way!!!