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Spironolactone Malaise Side Effects

Spironolactone Malaise Side Effect Reports


The following Spironolactone Malaise side effect reports were submitted by healthcare professionals and consumers.

This information will help you understand how side effects, such as Malaise, can occur, and what you can do about them.

A side effect could appear soon after you start Spironolactone or it might take time to develop.



Rash, Dyspnoea, Nervousness, Chest Discomfort, Nausea, Somnolence, Gastric Disorder, Malaise

This Malaise side effect was reported by a consumer or non-health professional from US. A 70-year-old female patient (weight:NA) experienced the following symptoms/conditions: local swelling. The patient was prescribed Spironolactone (dosage: 0.5 Df, 1x/day), which was started on 201401. Concurrently used drugs: NA. When starting to take Spironolactone the consumer reported the following symptoms:
  • Rash
  • Dyspnoea
  • Nervousness
  • Chest Discomfort
  • Nausea
  • Somnolence
  • Gastric Disorder
  • Malaise
These side effects may potentially be related to Spironolactone.
Renal Failure Acute, Malaise, Weight Increased, Urine Output Decreased, Musculoskeletal Pain, Dyspnoea, Vomiting, Acute Pulmonary Oedema

This Malaise Spironolactone side effect was reported by a health professional from GB on Jan 28, 2014. A Female , 50 years of age, weighting 202.8 lb, was diagnosed with and was treated with Spironolactone. The patient presented the following health conditions:
  • Renal Failure Acute
  • Malaise
  • Weight Increased
  • Urine Output Decreased
  • Musculoskeletal Pain
  • Dyspnoea
  • Vomiting
  • Acute Pulmonary Oedema
. Spironolactone dosage: 25 Milligram Daily; 25mg 1x/day. Additional drugs used at the same time:
  • Furosemide (160 Milligram Daily; 80mg 2x/day)
  • Inspra (25 Milligram Daily; 25mg 1x/day)
  • Bisoprolol (7.5 Milligram Daily; 7.5mg 1x/day)
  • Bisoprolol
  • Losartan (25 Milligram Daily; 25mg 1x/day)
  • Losartan
  • Ivabradine (10 Milligram Daily; 5mg 2x/day)
  • Ivabradine
The patient was hospitalized.
Malaise, Fatigue, Asthenia, Heart Rate Irregular, Abdominal Pain, Gingival Bleeding, Oropharyngeal Pain, Pharyngeal Oedema, Swelling Face

This is a Spironolactone side effect report of a 54-year-old female patient (weight:NA) from US, suffering from the following symptoms/conditions: cardiac failure congestive, who was treated with Spironolactone (dosage:1 Pill, Daily, Mouth, start time: Dec 04, 2013), combined with:
  • Alprazolam
  • Amitriptyline
  • Atorvastatin
  • Benicar
  • B12
  • Diphenoxylate
  • Folic Acid
  • Omeprazole
, and developed a serious reaction and a Malaise side effect. The patient presented with:
  • Malaise
  • Fatigue
  • Asthenia
  • Heart Rate Irregular
  • Abdominal Pain
  • Gingival Bleeding
  • Oropharyngeal Pain
  • Pharyngeal Oedema
  • Swelling Face
which developed after the beginning of treatment. The patient was hospitalized. This side effect report can indicate a possible existence of increased vulnerability to Spironolactone treatment in female patients suffering from cardiac failure congestive, resulting in Malaise.

Dehydration, Malaise, Weight Decreased, Stress, Off Label Use

A female patient (weight: NA) from US with the following symptoms: polycystic ovaries,glucose tolerance impaired started Spironolactone treatment (dosage: Unk) on NS. Soon after starting Spironolactone treatment, the consumer experienced several side effects, including:
  • Dehydration
  • Malaise
  • Weight Decreased
  • Stress
  • Off Label Use
. Concurrently used drugs:
  • Metformin Hcl (Unk)
This finding indicates that some patients can be more vulnerable to developing Spironolactone side effects, such as Malaise.
Type 2 Diabetes Mellitus, Infection, Hypertension, Furuncle, Wrist Fracture, Scar, Malaise

A female patient from UNITED STATES was prescribed and started Spironolactone on Apr 30, 2012. Patient felt the following Spironolactone side effects: type 2 diabetes mellitus, infection, hypertension, furuncle, wrist fracture, scar, malaise Additional patient health information: Female , weighting 209.0 lb, The consumer reported the following symptoms: was diagnosed with and. Spironolactone dosage: NA. Concurrently used drugs:
  • Aldactone
  • Advair Diskus 100/50
  • Levothyroxine (100 Ug, Unk)
  • Lisinopril (10 Mg, 1x/day)
  • Pravastatin (20 Mg, 1x/day)
  • Aldactone (25 Mg, 1x/day)
Gastrooesophageal Reflux Disease, Malaise

This report suggests a potential Spironolactone Malaise side effect(s) that can have serious consequences. A 56-year-old female patient from UNITED STATES (weight:NA) was diagnosed with the following health condition(s): NA and used Spironolactone (dosage: NA) starting NS. Soon after starting Spironolactone the patient began experiencing various side effects, including:
  • Gastrooesophageal Reflux Disease
  • Malaise
Drugs used concurrently:
  • Nexium
  • Ranitidine
Although Spironolactone demonstrated significant improvements in a number of clinically relevant cases, troublesome symptoms, such as Malaise, may still occur.
Rectal Haemorrhage, Hypersensitivity, Asthenia, Oedema Peripheral, Malaise, Dyspnoea, Anaemia, Polyp, Joint Swelling

An adverse event was reported by a physician on Jan 03, 2012 by a Female taking Spironolactone (dosage: NA) was diagnosed with and. Location: UNITED STATES , 76 years of age, patient began experiencing various side effects, including: Directly after treatment started, patient experienced the unwanted or unexpected Spironolactone side effects: rectal haemorrhage, hypersensitivity, asthenia, oedema peripheral, malaise, dyspnoea, anaemia, polyp, joint swelling. Additional medications/treatments:
Associated medications used:
  • Metoprolol Succinate
  • Brovana
  • Tracleer
  • Furosemide
The patient was hospitalized.
Renal Tubular Disorder, Metabolic Alkalosis, Decreased Appetite, Bone Marrow Failure, Malaise, Hypokalaemia, Hypomagnesaemia, Dehydration, Nausea

This Malaise problem was reported by a health professional from JAPAN. A 44-year-old female patient (weight: NA) was diagnosed with the following medical condition(s): NA.On Jun 01, 2009 a consumer started treatment with Spironolactone (dosage: 25 Mg, Unk). The following drugs/medications were being taken at the same time:
  • Sennoside (0.5 Mg, Unk)
  • Estazolam (2 Mg, Unk)
  • Zoledronic (4 Mg, Unk)
  • Diclofenac Sodium (7.5 Mg, Unk)
  • Ts 1 (100 Mg, Unk)
  • Omeprazole (20 Mg, Unk)
  • Cisplatin (80 Mg, Unk)
  • Furosemide (40 Mg, Unk)
When commencing Spironolactone, the patient experienced the following unwanted symptoms /side effects:
  • Renal Tubular Disorder
  • Metabolic Alkalosis
  • Decreased Appetite
  • Bone Marrow Failure
  • Malaise
  • Hypokalaemia
  • Hypomagnesaemia
  • Dehydration
  • Nausea
The patient was hospitalized. Although all drugs are carefully tested before they are licensed for use, they carry potential side effect risks. Some side effects, such as Malaise, may become evident only after a product is in use by the general population.
Blood Creatinine Increased, Fatigue, Hypophagia, Body Temperature Increased, Myalgia, Nephropathy, Malaise, Renal Failure Acute, Sepsis

This is a Spironolactone side effect report of a 73-year-old patient (weight: NA) from UNITED KINGDOM. The patient developed the following symptoms/conditions: NA and was treated with Spironolactone (dosage: 25 Mg, Unk) starting Feb 28, 2011. Concurrently used drugs:
  • Omeprazole (40 Mg, Unk)
  • Lactulose (15 Ml, Bid)
  • Warfarin Sodium (Unk)
  • Senokot /unk/ (1 Df, Qd)
  • Adizem-xl (120 Mg, Qd)
  • Aspirin (75 Mg, Qd)
  • Simvastatin (40 Mg, Qd)
  • Ranitidine (150 Mg, Bid)
Soon after that, the consumer experienced the following of symptoms:
  • Blood Creatinine Increased
  • Fatigue
  • Hypophagia
  • Body Temperature Increased
  • Myalgia
  • Nephropathy
  • Malaise
  • Renal Failure Acute
  • Sepsis
The patient was hospitalized. This opens a possibility that Spironolactone could cause Malaise and that some patients may be more susceptible.
Chest Pain, Dyspnoea, Blood Pressure Increased, Malaise, Weight Increased, Platelet Count Decreased, Aortic Valve Disease

This Malaise side effect was reported by a consumer or non-health professional from UNITED STATES on Nov 02, 2011. A patient from UNITED STATES , 72 years of age, was treated with Spironolactone. Directly after treatment started, patient experienced the unwanted or unexpected Spironolactone side effects: chest pain, dyspnoea, blood pressure increased, malaise, weight increased, platelet count decreased, aortic valve disease. Spironolactone dosage: NA.
Associated medications used:
  • Coreg
  • Nplate
  • Amiodarone Hcl
  • Simvastatin
  • Lisinopril (Unk)
  • Prednisone (40 Mg, Unk)
  • Pepcid Ac (Unk)
These side effects may potentially be related to Spironolactone.
Malaise, Dyspnoea, Hypotension, Back Pain

This Malaise side effect was reported by a consumer or non-health professional from DENMARK. A 76-year-old patient (weight:NA) experienced the following symptoms/conditions: cardiac disorder. The patient was prescribed Spironolactone (dosage: 25 Mg;qd), which was started on NS. Concurrently used drugs: NA. When starting to take Spironolactone the consumer reported the following symptoms:
  • Malaise
  • Dyspnoea
  • Hypotension
  • Back Pain
These side effects may potentially be related to Spironolactone.
Syncope, Lactic Acidosis, Fatigue, Malaise, Disorientation

This Malaise Spironolactone side effect was reported by a health professional from DENMARK on Sep 16, 2011. A male , 61 years of age, was treated with Spironolactone. The patient presented the following health conditions:
  • Syncope
  • Lactic Acidosis
  • Fatigue
  • Malaise
  • Disorientation
. Spironolactone dosage: NA. Additional drugs used at the same time:
  • Metformin Hcl (500 Mg;qam;po)
  • Ferro Duretter
  • Nexium
The patient was hospitalized.
Asthenia, Nausea, Swelling Face, Malaise, Feeling Hot, Weight Decreased, Blood Glucose Decreased, Gout, Decreased Appetite

This is a Spironolactone side effect report of a female patient (weight:NA) from UNITED STATES, suffering from the following symptoms/conditions: hypertension,type 2 diabetes mellitus, who was treated with Spironolactone (dosage:Unk, start time: NS), combined with:
  • Glimepiride (2 Mg, Bid)
  • Byetta (10 Ug, Bid)
  • Byetta (5 Ug, Unk)
  • Bystolic
, and developed a serious reaction and a Malaise side effect. The patient presented with:
  • Asthenia
  • Nausea
  • Swelling Face
  • Malaise
  • Feeling Hot
  • Weight Decreased
  • Blood Glucose Decreased
  • Gout
  • Decreased Appetite
which developed after the beginning of treatment. The patient was hospitalized. This side effect report can indicate a possible existence of increased vulnerability to Spironolactone treatment in female patients suffering from hypertension,type 2 diabetes mellitus, resulting in Malaise.
Cough, Urinary Incontinence, Malaise, Dyskinesia, Cardiac Failure Congestive, Weight Increased, Speech Disorder, Oedema Peripheral

A 47-year-old female patient (weight: NA) from UNITED STATES with the following symptoms: NA started Spironolactone treatment (dosage: NA) on NS. Soon after starting Spironolactone treatment, the consumer experienced several side effects, including:
  • Cough
  • Urinary Incontinence
  • Malaise
  • Dyskinesia
  • Cardiac Failure Congestive
  • Weight Increased
  • Speech Disorder
  • Oedema Peripheral
. Concurrently used drugs:
  • Atenolol
  • Hydrochlorothiazide
  • Buspirone
  • Lipitor
  • Lovaza
  • Spiriva
  • Effexor
  • Furosemide
This finding indicates that some patients can be more vulnerable to developing Spironolactone side effects, such as Malaise.
Blood Glucose Decreased, Asthenia, Nausea, Feeling Hot, Decreased Appetite, Dyspnoea, Malaise, Fatigue, Swelling Face

A female patient from UNITED STATES was prescribed and started Spironolactone on Jul 14, 2011. After Spironolactone was administered, patient encountered several Spironolactone side effects: blood glucose decreased, asthenia, nausea, feeling hot, decreased appetite, dyspnoea, malaise, fatigue, swelling face Additional patient health information: Female , weighting 209.0 lb, The consumer reported the following symptoms: was diagnosed with and. Spironolactone dosage: Unk. Concurrently used drugs:
  • Bystolic
  • Byetta (5 Ug, Unk)
  • Byetta (10 Ug, Bid)
  • Glimepiride (2 Mg, Bid)
The patient was hospitalized.
Pneumonia, Malaise, Blood Pressure Increased, Cough, Dyspnoea

This report suggests a potential Spironolactone Malaise side effect(s) that can have serious consequences. A patient from CANADA (weight:NA) was diagnosed with the following health condition(s): hypertension,crohn's disease and used Spironolactone (dosage: NA) starting Jan 22, 2011. Soon after starting Spironolactone the patient began experiencing various side effects, including:
  • Pneumonia
  • Malaise
  • Blood Pressure Increased
  • Cough
  • Dyspnoea
Drugs used concurrently:
  • Humira
  • Prednisone
The patient was hospitalized. Although Spironolactone demonstrated significant improvements in a number of clinically relevant cases, troublesome symptoms, such as Malaise, may still occur.
Increased Upper Airway Secretion, Muscle Tightness, Chest Pain, Back Pain, Dyspnoea, Chest Discomfort, Malaise, Cough

An adverse event was reported by a consumer or non-health professional on Jan 24, 2011 by a Female taking Spironolactone (dosage: Unk) . Location: UNITED STATES , 65 years of age, patient began experiencing various side effects, including: Patient felt the following Spironolactone side effects: increased upper airway secretion, muscle tightness, chest pain, back pain, dyspnoea, chest discomfort, malaise, cough. Additional medications/treatments:
Multiple prescriptions taken:
  • Enbrel (50 Mg, Qwk)
  • Lisinopril (Unk)
Malaise, Nausea, Product Odour Abnormal, Product Substitution Issue

This Malaise problem was reported by a consumer or non-health professional from UNITED STATES. A 31-year-old female patient (weight: NA) was diagnosed with the following medical condition(s): acne.On Jun 01, 2010 a consumer started treatment with Spironolactone (dosage: 1 Daily Po). The following drugs/medications were being taken at the same time: NA. When commencing Spironolactone, the patient experienced the following unwanted symptoms /side effects:
  • Malaise
  • Nausea
  • Product Odour Abnormal
  • Product Substitution Issue
Although all drugs are carefully tested before they are licensed for use, they carry potential side effect risks. Some side effects, such as Malaise, may become evident only after a product is in use by the general population.
Bradycardia, Dyspnoea, Hyperkalaemia, Loss Of Consciousness, Malaise

This is a Spironolactone side effect report of a 76-year-old patient (weight: NA) from GERMANY. The patient developed the following symptoms/conditions: oedema,hypertension,cardiovascular event prophylaxis and was treated with Spironolactone (dosage: 12.5 Mg, Qd) starting NS. Concurrently used drugs:
  • Bisoprolol (2.5 Mg, Qd)
  • Acetylsalicylic Acid (100 Mg, Qd)
  • Atacand (8 Mg, Qd)
  • Digitoxin
  • Ezetimibe/simvastatin (10 Mg Ezetimibe, 20 Mg Simvastatin)
  • Omeprazole (20 Mg, Qd)
  • Torasemide (10 Mg, Qd)
Soon after that, the consumer experienced the following of symptoms:
  • Bradycardia
  • Dyspnoea
  • Hyperkalaemia
  • Loss Of Consciousness
  • Malaise
The patient was hospitalized. This opens a possibility that Spironolactone could cause Malaise and that some patients may be more susceptible.
Cardiac Failure Congestive, Cardiomegaly, Chronic Obstructive Pulmonary Disease, Diabetes Mellitus Inadequate Control, Dyspnoea, Fall, Hypotension, Lower Respiratory Tract Infection, Malaise

This Malaise side effect was reported by a health professional from UNITED KINGDOM on Feb 04, 2010. A patient from UNITED KINGDOM , 65 years of age, was diagnosed with and was treated with Spironolactone. Patient felt the following Spironolactone side effects: cardiac failure congestive, cardiomegaly, chronic obstructive pulmonary disease, diabetes mellitus inadequate control, dyspnoea, fall, hypotension, lower respiratory tract infection, malaise. Spironolactone dosage: NA.
Multiple prescriptions taken:
  • Clozaril (Unk)
  • Stelazine
The patient was hospitalized. These side effects may potentially be related to Spironolactone.

DISCLAIMER: ALL DATA PROVIDED AS-IS, refer to terms of use for additional information.

Spironolactone Malaise Causes and Reviews


What is chronic fatigue syndrome?

Chronic fatigue syndrome (CFS) is a serious, long-term illness that affects many body systems. Another name for it is myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS). CFS can often make you unable to do your usual activities. Sometimes you may not even be able to get out of bed.

What are the symptoms of chronic fatigue syndrome?

CFS symptoms can include

  • Severe fatigue that is not improved by rest
  • Sleep problems
  • Post-exertional Malaise (PEM), where your symptoms get worse after any physical or mental activity
  • Problems with thinking and concentrating
  • Pain
  • Dizziness

CFS can be unpredictable. Your symptoms may come and go. They may change over time - sometimes they might get better, and other times they may get worse.

Who gets chronic fatigue syndrome?

Anyone can get CFS, but it is most common in people between 40 and 60 years old. Adult women have it more often that adult men. Whites are more likely than other races to get a diagnosis of CFS, but many people with CFS have not been diagnosed with it.

What causes chronic fatigue syndrome?

Scientists don't know what causes CFS. There may be more than one thing that causes it. It is possible that two or more triggers might work together to cause the illness.

How is chronic fatigue syndrome diagnosed?

CFS can be difficult to diagnose. There are no tests for it, and other illnesses can cause similar symptoms. Your health care provider has to rule out other diseases before making a diagnosis of CFS. He or she will do a thorough medical exam, including

  • Asking about your health history and your family's medical history
  • Asking about your current illness, including your symptoms. Your doctor will want to know how often you have symptoms, how bad they are, how long they have lasted, and how they affect your life.
  • A thorough physical and mental status exam
  • Blood, urine or other tests
What are the treatments for chronic fatigue syndrome?

There is no cure or approved treatment for CFS, but you may be able to treat or manage some of your symptoms. You, your family, and your health care provider should work together to decide on a plan. You should figure out which symptom causes the most problems, and try to treat that first. For example, if sleep problems affect you the most, you might first try using good sleep habits. If those do not help, you may need to take medicines or see a sleep specialist.

Strategies such as learning new ways to manage activity can also be helpful. You need to make sure that you do not "push and crash." This can happen when you feel better, do too much, and then get worse again.

Since the process of developing a treatment plan and attending to self-care can be hard if you have CFS, it is important to have support from family members and friends.

Don't try any new treatments without talking to your health care provider. Some treatments that are promoted as cures for CFS are unproven, often costly, and could be dangerous.

Centers for Disease Control and Prevention


Spironolactone Malaise Reviews

Tue, 09 Nov 2010

I am a female patient from NY, age 33. I am being treated for Hashimoto Thyroiditis with Synthroid and Cytomel. I was concerned that after 11 years since my diagnosis, my hair is still falling out at an alarming rate. My doctor noticed that my testosterone levels were a bit high and decided to treat me with Spironolactone (50 MG). I noticed no difference in the amount of hair loss but have been having constant, uncomfortable eye spasms and a breast tenderness as well as breast enlargement. This is just after a little over a month of treatment. I will stop taking Spironolactone as I do not see it as being beneficial to me.

Wed, 02 May 2012

I'm a 29 year old female and started taking spiro to get rid of my persistent adult acne. I took 100mg a day for about 2 weeks and it worked really quickly to clear my skin, I also went up an entire cup size which was a bonus and because it stopped any fluid retention I lost a bit of weight as well.
Unfortunately I had to stop taking it because of the side effects. The worst was a really low mood and anxiety, I would take it and half an hour later have to skull 2-3 litres of water, wee it all out and then couldn't sleep because my heart was racing to much and I felt really on edge. I also felt slightly nauseous all of the time (probably contributed to the weight loss) and found that it made me fart a lot. 
I'm going to try it again though, this time on a lower dosage just a few times a week to see how that goes.

Thu, 18 Aug 2011

mid morningstablets of 25 mg working very well at reducing excess water -edema-but have bouts of diarrhorea

Sat, 16 Jan 2010
I was on Spironolactone (12.5 daily) . Hindsight, almost immediately I began suffering from ED. Mixed symptoms thought at the time from Diabetes T2 . Was also on Ace Inhibitors, Digoxin, Ibuprofenm Furosemide. After 18 months suddenly developed MAJOR heartburn and EXTREMELY sore nipples. When GP was told of new symptons, was immediately told to halt Spiron. I have been off of it for 4 months now, but STILL experience nipple pain. Can anyone tell me how to stop the pain ?? I was told that it would go away, but I am starting to wonder. I am a 58 yo WM, 5'7, 250# . My chest has increased 2 'cup' sizes at least. Would like to find out how to reverse these unwanted effects.
Thu, 03 Feb 2011
Painful intercorse
Wed, 18 May 2011
I'm 27 f female from aust, i have been taking Spironolactone for about four months now. I have been prescribed this due to hair loss (thining really quickly) and i have found it to be amazing! I have been having mood swings as a result and headaches... however apart from that I couldnt be happier. My hair has stopped falling out! the hair i have is so much thicker and healthier... i dont wear a hat anymore and i got a knot in my hair for the first time yesterday.. sounds strange, but i was over the moon about it :) being able to grow my hair again has made me so happy I have had to take regular blood test to keep an eye on my levels. So far so good :)
DISCLAIMER: ALL DATA PROVIDED AS-IS, refer to terms of use for additional information.

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Top Spironolactone Side Effects

Hyperkalaemia (208)
Renal Failure Acute (103)
Dyspnoea (81)
Dehydration (59)
Asthenia (56)
Gynaecomastia (55)
Diarrhoea (52)
Nausea (50)
Blood Potassium Increased (50)
Blood Creatinine Increased (48)
Fatigue (46)
Hypotension (43)
Renal Failure (41)
Dizziness (40)
Pain (37)
Bradycardia (36)
Vomiting (33)
Hyponatraemia (33)
Oedema Peripheral (31)
Atrial Fibrillation (28)
Renal Impairment (28)
Condition Aggravated (27)
Malaise (26)
Chest Pain (25)
Cardiac Failure (25)
Cough (25)
Fall (25)
Anaemia (24)
Pyrexia (23)
Pruritus (23)
Back Pain (22)
Rash (22)
Death (21)
Hypertension (21)
Blood Urea Increased (20)
Anxiety (20)
Blood Pressure Decreased (20)
Cardiac Failure Congestive (20)
Headache (20)
Weight Increased (19)
Pulmonary Embolism (18)
Blood Pressure Increased (18)
Breast Pain (18)
Confusional State (17)
Weight Decreased (17)
Hypokalaemia (17)
Syncope (16)
Pneumonia (16)
Myocardial Infarction (16)
Oedema (15)

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