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Spironolactone Renal Failure Side Effects

Spironolactone Renal Failure Side Effect Reports


The following Spironolactone Renal Failure side effect reports were submitted by healthcare professionals and consumers.

This information will help you understand how side effects, such as Renal Failure, can occur, and what you can do about them.

A side effect could appear soon after you start Spironolactone or it might take time to develop.



Dizziness, Asthenia, Renal Failure, Ventricular Extrasystoles

This Renal Failure side effect was reported by a health professional from RU. A 75-year-old patient (weight:NA) experienced the following symptoms/conditions: cardiac failure chronic. The patient was prescribed Spironolactone (dosage: 50 Mg/day), which was started on NS. Concurrently used drugs:
  • Enalapril (20 Mg/day)
  • Digoxin (0.375 Mg Daily)
  • Pradaxa (220 Mg/day)
  • Metoprolol Succinate (150 Mg Daily)
  • Amlodipine (2.5 Mg Daily)
  • Furosemide (80 Mg Daily)
  • Atorvastatin (20 Mg Daily)
  • Diabetone (30 Mg Daily)
When starting to take Spironolactone the consumer reported the following symptoms:
  • Dizziness
  • Asthenia
  • Renal Failure
  • Ventricular Extrasystoles
The patient was hospitalized. These side effects may potentially be related to Spironolactone.
Hyperkalaemia, Orthostatic Hypotension, Renal Failure, Fatigue

This Renal Failure Spironolactone side effect was reported by a health professional from US on Aug 08, 2013. A Female , 89 years of age, was treated with Spironolactone. The patient presented the following health conditions:
  • Hyperkalaemia
  • Orthostatic Hypotension
  • Renal Failure
  • Fatigue
. Spironolactone dosage: NA. Additional drugs used at the same time:
  • Hctz -olmesartan (hydrochlorthiazide, Olmesartan Medoxomil) 9hydrochlorthiazide, Olmesartan Medoxomi
  • Metoprolol Tartrate
  • Amlodipine Besilate (10 Mg Once Daily Oral,30-aug-2006 To Ongoing.)
  • Atorvastatin
  • Fosinopril
  • Glipizide
  • Doxazosin (8 Mg, Once Daily, Oral, 16/6/2006, Stopped.)
Renal Failure, Haemorrhage

This is a Spironolactone side effect report of a 75-year-old patient (weight:NA) from RU, suffering from the following symptoms/conditions: cardiac failure chronic,atrial fibrillation, who was treated with Spironolactone (dosage:50 Mg, Daily, start time: 201210), combined with: NA., and developed a serious reaction and a Renal Failure side effect. The patient presented with:
  • Renal Failure
  • Haemorrhage
which developed after the beginning of treatment. The patient was hospitalized. This side effect report can indicate a possible existence of increased vulnerability to Spironolactone treatment in patients suffering from cardiac failure chronic,atrial fibrillation, resulting in Renal Failure.

Anaemia, Renal Failure

A 56-year-old female patient (weight: NA) from FR with the following symptoms: cirrhosis alcoholic started Spironolactone treatment (dosage: 75 Mg, 3x/day) on 201304. Soon after starting Spironolactone treatment, the consumer experienced several side effects, including:
  • Anaemia
  • Renal Failure
. Concurrently used drugs:
  • Lasilix (80 Mg, Daily)
  • Inexium (40 Mg, 1x/day)
  • Avlocardyl (40 Mg, 2x/day)
  • Vitamin B1 And B6
The patient was hospitalized. This finding indicates that some patients can be more vulnerable to developing Spironolactone side effects, such as Renal Failure.
Hyperkalaemia, Anaemia, Renal Failure

A patient from DE was prescribed and started Spironolactone on Jun 19, 2013. Patient felt the following Spironolactone side effects: hyperkalaemia, anaemia, renal failure Additional patient health information: male , 71 years of age, weighting 198.6 lb, The consumer reported the following symptoms: . Spironolactone dosage: NA. Concurrently used drugs: NA. The patient was hospitalized.
Electrolyte Imbalance, Intestinal Ischaemia, Gastrointestinal Oedema, Renal Failure, Cholelithiasis, Faeces Discoloured, Nausea, Nephrolithiasis

This report suggests a potential Spironolactone Renal Failure side effect(s) that can have serious consequences. A 80-year-old female patient from HUNGARY (weight:NA) was diagnosed with the following health condition(s): NA and used Spironolactone (dosage: NA) starting Oct 07, 2011. Soon after starting Spironolactone the patient began experiencing various side effects, including:
  • Electrolyte Imbalance
  • Intestinal Ischaemia
  • Gastrointestinal Oedema
  • Renal Failure
  • Cholelithiasis
  • Faeces Discoloured
  • Nausea
  • Nephrolithiasis
Drugs used concurrently:
  • Diaprel
  • Teriparatide (Unk)
  • D3
  • Tramadol Hcl
  • Digoxin
  • Noacid
  • Ferrograd Folic
  • Frontin
The patient was hospitalized. Although Spironolactone demonstrated significant improvements in a number of clinically relevant cases, troublesome symptoms, such as Renal Failure, may still occur.
Cardiac Failure Congestive, Renal Failure, Pulmonary Arterial Hypertension, Diabetes Mellitus, Abasia

An adverse event was reported by a consumer or non-health professional on Apr 11, 2012 by a Female taking Spironolactone (dosage: NA) . Location: UNITED STATES , 59 years of age, weighting 350.5 lb, patient began experiencing various side effects, including: Directly after treatment started, patient experienced the unwanted or unexpected Spironolactone side effects: cardiac failure congestive, renal failure, pulmonary arterial hypertension, diabetes mellitus, abasia. Additional medications/treatments:
Associated medications used:
  • Levothyroxine Sodium
  • Tadalafil
  • Lasix
  • Celebrex
Disease Progression, Renal Failure, Angiogram Abnormal, Biopsy Cartilage Abnormal, Clubbing, Condition Aggravated, Cough, Echocardiogram Abnormal

This Renal Failure problem was reported by a consumer or non-health professional from UNITED STATES. A female patient (weight: NA) was diagnosed with the following medical condition(s): NA.On Jan 09, 2006 a consumer started treatment with Spironolactone (dosage: NA). The following drugs/medications were being taken at the same time:
  • Lovenox
  • Isosorbide Dinitrate
  • Chlor
  • Dilaudid
  • Lisinopril
  • Erythromycin (For 10 Days)
  • Imdur
  • Morphine
When commencing Spironolactone, the patient experienced the following unwanted symptoms /side effects:
  • Disease Progression
  • Renal Failure
  • Angiogram Abnormal
  • Biopsy Cartilage Abnormal
  • Clubbing
  • Condition Aggravated
  • Cough
  • Echocardiogram Abnormal
The patient was hospitalized and became disabled. Although all drugs are carefully tested before they are licensed for use, they carry potential side effect risks. Some side effects, such as Renal Failure, may become evident only after a product is in use by the general population.
Renal Failure, Paraesthesia

This is a Spironolactone side effect report of a 84-year-old patient (weight: NA) from FRANCE. The patient developed the following symptoms/conditions: NA and was treated with Spironolactone (dosage: NA) starting Jan 23, 2012. Concurrently used drugs:
  • Vancomycin (Unk)
  • Prazosin
  • Salicylic Acid
  • Rifadin (300 Mg)
  • Omeprazole
  • Fluindione
  • Zyvox (600 Mg, 2x/day)
  • Furosemide
Soon after that, the consumer experienced the following of symptoms:
  • Renal Failure
  • Paraesthesia
This opens a possibility that Spironolactone could cause Renal Failure and that some patients may be more susceptible.
Renal Failure, Hypotension

This Renal Failure side effect was reported by a physician from UNITED STATES on Mar 16, 2012. A patient from UNITED STATES , 59 years of age, was treated with Spironolactone. Directly after treatment started, patient experienced the unwanted or unexpected Spironolactone side effects: renal failure, hypotension. Spironolactone dosage: NA.
Associated medications used:
  • Carvedilol
  • Furosemide
  • Torsemide
  • Aspirin
The patient was hospitalized. These side effects may potentially be related to Spironolactone.
Renal Failure, Cardiac Failure Congestive, Diabetes Mellitus, Gait Disturbance, Pulmonary Arterial Hypertension, Renal Disorder

This Renal Failure side effect was reported by a consumer or non-health professional from UNITED STATES. A female patient (weight:NA) experienced the following symptoms/conditions: cardiac failure congestive,hypothyroidism. The patient was prescribed Spironolactone (dosage: Unk), which was started on NS. Concurrently used drugs:
  • Levothyroxine (200 Ug, Daily)
  • Lasix (Unk)
  • Celebrex (200 Mg, 2x/day)
  • Tadalafil (20 Mg, 2x/day)
When starting to take Spironolactone the consumer reported the following symptoms:
  • Renal Failure
  • Cardiac Failure Congestive
  • Diabetes Mellitus
  • Gait Disturbance
  • Pulmonary Arterial Hypertension
  • Renal Disorder
These side effects may potentially be related to Spironolactone.
Nodal Rhythm, Blood Glucose Increased, Respiratory Distress, Atrioventricular Block Complete, Sinus Arrest, Haemoglobin Decreased, Renal Failure

This Renal Failure Spironolactone side effect was reported by a health professional from UNITED STATES on Jan 14, 2012. A male , 70 years of age, was treated with Spironolactone. The patient presented the following health conditions:
  • Nodal Rhythm
  • Blood Glucose Increased
  • Respiratory Distress
  • Atrioventricular Block Complete
  • Sinus Arrest
  • Haemoglobin Decreased
  • Renal Failure
. Spironolactone dosage: NA. Additional drugs used at the same time:
  • Valsartan
  • Insulin
  • Carvedilol
The patient was hospitalized.
Heart Rate Decreased, Renal Failure, Rales, Asthenia, Atrioventricular Block, Hyperkalaemia, Respiratory Distress, Dyspnoea, Body Temperature Decreased

This is a Spironolactone side effect report of a 70-year-old patient (weight:NA) from UNITED STATES, suffering from the following symptoms/conditions: NA, who was treated with Spironolactone (dosage:NA, start time: NS), combined with:
  • Insulin
  • Carvedilol
  • Valsartan
, and developed a serious reaction and a Renal Failure side effect. The patient presented with:
  • Heart Rate Decreased
  • Renal Failure
  • Rales
  • Asthenia
  • Atrioventricular Block
  • Hyperkalaemia
  • Respiratory Distress
  • Dyspnoea
  • Body Temperature Decreased
which developed after the beginning of treatment. The patient was hospitalized. This side effect report can indicate a possible existence of increased vulnerability to Spironolactone treatment in patients suffering from NA, resulting in Renal Failure.
Dehydration, C-reactive Protein Increased, Bladder Cancer, Renal Failure, Blood Urine Present, Infection, Blood Creatinine Increased, Blood Glucose Increased

A female patient (weight: NA) from NETHERLANDS with the following symptoms: cardiac failure started Spironolactone treatment (dosage: 25 Mg/day) on Jan 01, 2009. Soon after starting Spironolactone treatment, the consumer experienced several side effects, including:
  • Dehydration
  • C-reactive Protein Increased
  • Bladder Cancer
  • Renal Failure
  • Blood Urine Present
  • Infection
  • Blood Creatinine Increased
  • Blood Glucose Increased
. Concurrently used drugs:
  • Simvastatin
  • Metoprolol Succinate (200 Mg/day)
  • Tolbutamide (50 Mg/day)
  • Atenolol (100 Mg/day)
  • Aliskiren (150 Mg, Unk)
  • Calcitriol (500 Mg, Qd)
  • Enalapril Maleate (20 Mg, Bid)
  • Metformin Hcl (500 Mg, Bid)
This finding indicates that some patients can be more vulnerable to developing Spironolactone side effects, such as Renal Failure.
Renal Injury, Anxiety, Renal Impairment, Emotional Distress, Multi-organ Failure, Renal Failure

A patient from UNITED STATES was prescribed and started Spironolactone on Dec 14, 2011. After Spironolactone was administered, patient encountered several Spironolactone side effects: renal injury, anxiety, renal impairment, emotional distress, multi-organ failure, renal failure Additional patient health information: male , 76 years of age, weighting 180.0 lb, The consumer reported the following symptoms: . Spironolactone dosage: Unk. Concurrently used drugs:
  • Trasylol
  • Norvasc
  • Trasylol (200 Ml X 2, Unk)
  • Synthroid
Renal Failure, Acute Abdomen, Respiratory Failure, Overdose, Gastric Ulcer

This report suggests a potential Spironolactone Renal Failure side effect(s) that can have serious consequences. A patient from GERMANY (weight:NA) was diagnosed with the following health condition(s): cardiac failure,asthma,atrial fibrillation,ulcer and used Spironolactone (dosage: 50 Mg) starting Oct 20, 2011. Soon after starting Spironolactone the patient began experiencing various side effects, including:
  • Renal Failure
  • Acute Abdomen
  • Respiratory Failure
  • Overdose
  • Gastric Ulcer
Drugs used concurrently:
  • Theophylline (375 Mg)
  • Pradaxa (220 Mg)
  • Pantoprazole (20 Mg)
  • Prednisolone (5 Mg)
  • Furosemide (40 Mg)
  • Xipamid (20 Mg)
Although Spironolactone demonstrated significant improvements in a number of clinically relevant cases, troublesome symptoms, such as Renal Failure, may still occur.
Dementia Alzheimer's Type, Femur Fracture, Renal Failure, Off Label Use

An adverse event was reported by a consumer or non-health professional on Jun 20, 2011 by a Female taking Spironolactone (dosage: NA) . Location: BRAZIL , 84 years of age, weighting 149.9 lb, patient began experiencing various side effects, including: Patient felt the following Spironolactone side effects: dementia alzheimer's type, femur fracture, renal failure, off label use. Additional medications/treatments:
Multiple prescriptions taken:
  • Memantine Hydrochloride
  • Atacand Hct (16/12.5 Mg Od)
  • Nebivolol Hcl
  • Seroquel
  • Alois
The patient was hospitalized and became disabled.
Renal Failure, Hyperkalaemia

This Renal Failure problem was reported by a physician from SWEDEN. A 81-year-old female patient (weight: NA) was diagnosed with the following medical condition(s): myocardial infarction.On Oct 19, 2001 a consumer started treatment with Spironolactone (dosage: NA). The following drugs/medications were being taken at the same time:
  • Digoxin
  • Isoptin
  • Acetaminophen
  • Waran
  • Omeprazole
  • Metoprolol Sandoz
  • Behepan
  • Duroferon
When commencing Spironolactone, the patient experienced the following unwanted symptoms /side effects:
  • Renal Failure
  • Hyperkalaemia
The patient was hospitalized. Although all drugs are carefully tested before they are licensed for use, they carry potential side effect risks. Some side effects, such as Renal Failure, may become evident only after a product is in use by the general population.
Renal Injury, Stress, Anxiety, Renal Failure, Fear, Renal Impairment, Unevaluable Event, Anhedonia

This is a Spironolactone side effect report of a 69-year-old female patient (weight: NA) from UNITED STATES. The patient developed the following symptoms/conditions: NA and was treated with Spironolactone (dosage: 25mg) starting Aug 05, 2001. Concurrently used drugs:
  • Cardizem (120mg Daily)
  • Coumadin (2.5mg-no Pill Sundays)
  • Captopril (Unk)
  • Coreg (0.25mg ? Tab Bid)
  • Trasylol (, Loading Dose Of 200ml, Then 50cc Per Hour Drip)
  • Insulin (Unk)
  • Acetylsalicylic Acid Srt
  • Trasylol (Initial (test) Dose Of 1 Ml)
Soon after that, the consumer experienced the following of symptoms:
  • Renal Injury
  • Stress
  • Anxiety
  • Renal Failure
  • Fear
  • Renal Impairment
  • Unevaluable Event
  • Anhedonia
This opens a possibility that Spironolactone could cause Renal Failure and that some female patients may be more susceptible.
Unevaluable Event, Psychiatric Symptom, Pain, Renal Failure, Renal Failure Acute, Injury

This Renal Failure side effect was reported by a consumer or non-health professional from UNITED STATES on Oct 31, 2009. A female patient from UNITED STATES , 35 years of age, weighting 163.1 lb, was treated with Spironolactone. Patient felt the following Spironolactone side effects: unevaluable event, psychiatric symptom, pain, renal failure, renal failure acute, injury. Spironolactone dosage: 50 Mg, Qd.
Multiple prescriptions taken:
  • Nipride (Unk)
  • Trasylol (200 Ml (prime Pump))
  • Trasylol (1 Ml, Once (initial))
  • Fresh Frozen Plasma (2 U, Unk)
  • Nitro-bid (Every 12 Hrs)
  • Lasix (140 Mg, Unk)
  • Pavulon (Unk)
  • Calcium Chloride (Unk)
The patient was hospitalized. These side effects may potentially be related to Spironolactone.
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DISCLAIMER: ALL DATA PROVIDED AS-IS, refer to terms of use for additional information.

Spironolactone Renal Failure Causes and Reviews


Healthy kidneys clean your blood by removing excess fluid, minerals, and wastes. They also make hormones that keep your bones strong and your blood healthy. But if the kidneys are damaged, they don't work properly. Harmful wastes can build up in your body. Your blood pressure may rise. Your body may retain excess fluid and not make enough red blood cells. This is called kidney failure.

If your kidneys fail, you need treatment to replace the work they normally do. The treatment options are dialysis or a kidney transplant. Each treatment has benefits and drawbacks. No matter which treatment you choose, you'll need to make some changes in your life, including how you eat and plan your activities. But with the help of health care providers, family, and friends, most people with kidney failure can lead full and active lives.

NIH: National Institute of Diabetes and Digestive and Kidney Diseases


Spironolactone Renal Failure Reviews

Tue, 09 Nov 2010

I am a female patient from NY, age 33. I am being treated for Hashimoto Thyroiditis with Synthroid and Cytomel. I was concerned that after 11 years since my diagnosis, my hair is still falling out at an alarming rate. My doctor noticed that my testosterone levels were a bit high and decided to treat me with Spironolactone (50 MG). I noticed no difference in the amount of hair loss but have been having constant, uncomfortable eye spasms and a breast tenderness as well as breast enlargement. This is just after a little over a month of treatment. I will stop taking Spironolactone as I do not see it as being beneficial to me.

Wed, 02 May 2012

I'm a 29 year old female and started taking spiro to get rid of my persistent adult acne. I took 100mg a day for about 2 weeks and it worked really quickly to clear my skin, I also went up an entire cup size which was a bonus and because it stopped any fluid retention I lost a bit of weight as well.
Unfortunately I had to stop taking it because of the side effects. The worst was a really low mood and anxiety, I would take it and half an hour later have to skull 2-3 litres of water, wee it all out and then couldn't sleep because my heart was racing to much and I felt really on edge. I also felt slightly nauseous all of the time (probably contributed to the weight loss) and found that it made me fart a lot. 
I'm going to try it again though, this time on a lower dosage just a few times a week to see how that goes.

Thu, 18 Aug 2011

mid morningstablets of 25 mg working very well at reducing excess water -edema-but have bouts of diarrhorea

Sat, 16 Jan 2010
I was on Spironolactone (12.5 daily) . Hindsight, almost immediately I began suffering from ED. Mixed symptoms thought at the time from Diabetes T2 . Was also on Ace Inhibitors, Digoxin, Ibuprofenm Furosemide. After 18 months suddenly developed MAJOR heartburn and EXTREMELY sore nipples. When GP was told of new symptons, was immediately told to halt Spiron. I have been off of it for 4 months now, but STILL experience nipple pain. Can anyone tell me how to stop the pain ?? I was told that it would go away, but I am starting to wonder. I am a 58 yo WM, 5'7, 250# . My chest has increased 2 'cup' sizes at least. Would like to find out how to reverse these unwanted effects.
Thu, 03 Feb 2011
Painful intercorse
Wed, 18 May 2011
I'm 27 f female from aust, i have been taking Spironolactone for about four months now. I have been prescribed this due to hair loss (thining really quickly) and i have found it to be amazing! I have been having mood swings as a result and headaches... however apart from that I couldnt be happier. My hair has stopped falling out! the hair i have is so much thicker and healthier... i dont wear a hat anymore and i got a knot in my hair for the first time yesterday.. sounds strange, but i was over the moon about it :) being able to grow my hair again has made me so happy I have had to take regular blood test to keep an eye on my levels. So far so good :)
DISCLAIMER: ALL DATA PROVIDED AS-IS, refer to terms of use for additional information.

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Top Spironolactone Side Effects

Hyperkalaemia (208)
Renal Failure Acute (103)
Dyspnoea (81)
Dehydration (59)
Asthenia (56)
Gynaecomastia (55)
Diarrhoea (52)
Nausea (50)
Blood Potassium Increased (50)
Blood Creatinine Increased (48)
Fatigue (46)
Hypotension (43)
Renal Failure (41)
Dizziness (40)
Pain (37)
Bradycardia (36)
Vomiting (33)
Hyponatraemia (33)
Oedema Peripheral (31)
Atrial Fibrillation (28)
Renal Impairment (28)
Condition Aggravated (27)
Malaise (26)
Chest Pain (25)
Cardiac Failure (25)
Cough (25)
Fall (25)
Anaemia (24)
Pyrexia (23)
Pruritus (23)
Back Pain (22)
Rash (22)
Death (21)
Hypertension (21)
Blood Urea Increased (20)
Anxiety (20)
Blood Pressure Decreased (20)
Cardiac Failure Congestive (20)
Headache (20)
Weight Increased (19)
Pulmonary Embolism (18)
Blood Pressure Increased (18)
Breast Pain (18)
Confusional State (17)
Weight Decreased (17)
Hypokalaemia (17)
Syncope (16)
Pneumonia (16)
Myocardial Infarction (16)
Oedema (15)

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