Severe Asthma | Phenotyping Asthma for Bronchial Thermoplasty
Severe Asthma research study
What is the primary objective of this study?
This study will evaluate a new imaging technology, called optical coherence tomography (OCT)
to examine the asthmatic airways before and after bronchial thermoplasty, which is a new
treatment option for severe asthmatic patients. The aim of this study is to learn more about
how airways respond to this new treatment. In the future the investigators hope OCT will aid
clinicians in the initial assessment, management and long-term follow up of patients
receiving bronchial thermoplasty.
Who is eligible to participate?
1. Patient undergoing elective bronchial thermoplasty
2. Patient is between the ages of 18 and 60
3. Patient is able to give informed consent
4. Negative pregnancy test for all female of childbearing potential who are sexually
active and not using contraception, are seeking to become pregnant, or who are
5. Nonsmoking (<5 pack year tobacco exposure)
6. No history of co-existing lung disease
7. Meet American Thoracic Society criteria for diagnosis of asthma with either/or
1. Bronchodilator response to albuterol (≥12% change in FEV1)
2. Positive methacholine bronchoprovocation (PC20 < 25 mg/ml)
1. Patients who are pregnant.
2. Patient does not meet the requirements to undergo clinical bronchial thermoplasty, as
determined by the treating physician
Which medical condition, disease, disorder, syndrome, illness, or injury is researched?
Interventions can include giving participants drugs, medical devices, procedures, vaccines, and other products that are either investigational or already available or noninvasive approaches such as surveys, education, and interviews.
Research studies and clinical trials typically have two or more research arms. An arm is a group of people who receive the same treatment in the study.
Not yet recruiting
Start Date: April 2018
Completed Date: December 2022
Primary Outcome: Evaluate OCT for assessing bronchial thermoplasty
Study sponsors, principal investigator, and references
Principal Investigator: Melissa J Suter, PhD
Lead Sponsor: Massachusetts General Hospital
Collaborator: National Heart, Lung, and Blood Institute (NHLBI)