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Adverse Effects | Aggressive Behavior Induced by Selective Serotonin Reuptake Inhibitors (SSRIs) During the First Month of Treatment

Adverse Effects research study

What is the primary objective of this study?

SSRIs are the first line of therapy for anxiety and depressive disorders and for many other clinical diagnoses. One of the most disturbing side effects that is observed is a tendency towards aggressiveness among patients receiving medications from this group, mainly during the first month of therapy. Aggressive behavior tends to occur in some individuals but not in others. In some sub-groups of people, personality and character traits might make a person more prone to aggressive behavior. In this study the investigators try to estimate the tendency towards aggressive behavior in patients prescribed to a medication from the SSRI group. By using a comparative computer simulation they hope to be able to detect delicate changes and to maybe get some clues of the personalities prone to aggressive behavior in the future.

Who is eligible to participate?

Inclusion Criteria: - Age above 18 years - Instructed by his/her family physician to start taking a medicine in the SSRI group Exclusion Criteria: - According to the family practitioner's record: under SSRI, SNRI, or NRI treatment during the previous 3 months or at the time of entry into the study. - Diagnosed with schizophrenia or active psychosis or impaired judgment - Anti-social personality disorder - Drug use or alcohol abuse

Which medical condition, disease, disorder, syndrome, illness, or injury is researched?

Adverse Effects

Aggression

Study Interventions

Interventions can include giving participants drugs, medical devices, procedures, vaccines, and other products that are either investigational or already available or noninvasive approaches such as surveys, education, and interviews.

Behavioral:comparative computer simulationcomparative computer simulation assessing the level of aggressiveness before and after the beginning of SSRI treatment.

Study Arms

Research studies and clinical trials typically have two or more research arms. An arm is a group of people who receive the same treatment in the study.

Study Status

Unknown status

Start Date: September 2006

Completed Date:

Phase: N/A

Type: Interventional

Design:

Primary Outcome: aggressiveness level

Secondary Outcome:

Study sponsors, principal investigator, and references

Principal Investigator: Dalya Navot-Mintzer, MD

Lead Sponsor: HaEmek Medical Center, Israel

Collaborator:

More information:https://clinicaltrials.gov/show/NCT00361062

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