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Postoperative Agitation of Patients | A RCT of Compound Lidocaine Cream to Prevent Postoperative Agitation in Patients With Endotracheal Intubation for GA

Postoperative Agitation of Patients research study

What is the primary objective of this study?

The purpose of this study is to determine whether the compound lidocaine cream is effective in preventing postoperative agitation in patients with endotracheal intubation for general anesthesia.

Who is eligible to participate?

Inclusion Criteria: - aged over 18 - selective operation patients with endotracheal intubation for general anesthesia Exclusion Criteria: - highly sensitive to local anesthetics of amide derivatives or anything else in compound lidocaine cream - congenital or idiopathic methemoglobinemia

Which medical condition, disease, disorder, syndrome, illness, or injury is researched?

Postoperative Agitation of Patients

Study Interventions

Interventions can include giving participants drugs, medical devices, procedures, vaccines, and other products that are either investigational or already available or noninvasive approaches such as surveys, education, and interviews.

Drug:Compound Lidocaine CreamCompound Lidocaine Cream ,1-2 grams per person.

Study Arms

Research studies and clinical trials typically have two or more research arms. An arm is a group of people who receive the same treatment in the study.

Compound Lidocaine CreamThe cuff of endotracheal tube is covered by 1-2g compound lidocaine cream before the general anesthesia.

blank controlNo intervention.

Study Status

Unknown status

Start Date: December 2013

Completed Date: April 2014

Phase: Phase 4

Type: Interventional

Design:

Primary Outcome: Vital signs like blood pressure and heart rates during extubation.

Secondary Outcome: The cough reflex and breath holding during extubation.

Study sponsors, principal investigator, and references

Principal Investigator: Xun Liu, Associate Professor

Lead Sponsor: Third Affiliated Hospital, Sun Yat-Sen University

Collaborator:

More information:https://clinicaltrials.gov/show/NCT02017392

Batai I, Bogar L, Juhasz V, Batai R, Kerenyi M. A comparison of the antimicrobial property of lidocaine/prilocaine cream (EMLA) and an alcohol-based disinfectant on intact human skin flora. Anesth Analg. 2009 Feb;108(2):666-8. doi: 10.1213/ane.0b013e31818f887e.

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