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Older Adults | Age-Dependent Memory Benefits From Pharmacologically Enhanced Naps?

Older Adults research study

What is the primary objective of this study?

The purpose of this study is to investigate whether 1. pharmacologically enhanced naps will show increases in specific sleep stages 2. whether these sleep stages will produces specific increases on memory tests 3. whether older adults will benefit more than young adults from increased SWS or Stage 2 on subsequent declarative and motor memory tests.

Who is eligible to participate?

Inclusion Criteria: - English-speaking individuals, half men and half women, and between the ages of 60 and 75 years will be recruited. No ethnic group will be specifically excluded from study. All participants will be recruited from general San Diego Community. An education requirement of at least 12 years completed will be imposed, as education may affect performance on the cognitive task. Exclusion Criteria: - Not having a regular sleep-wake schedule (defined as not meeting criteria listed above and/or a Horne-Ostberg Morningness-Eveningness Questionnaire score not between 31-69) - Having a sleep disorder (reported or detected on the questionnaires) - Any personal or immediate family (i.e., first degree relative) history of diagnosed significant psychopathology - Personal history of head injury with loss of consciousness greater than 15 minutes or seizures - History of substance dependence - Current use of any psychotropic medications - Any cardiac, respiratory or other medical condition which may affect cerebral metabolism - Given the nature of the stimulus and its presentation, anyone with non-correctable vision and audition impairments will also be excluded.

Which medical condition, disease, disorder, syndrome, illness, or injury is researched?

Older Adults

Study Interventions

Interventions can include giving participants drugs, medical devices, procedures, vaccines, and other products that are either investigational or already available or noninvasive approaches such as surveys, education, and interviews.

Drug:Sodium Oxybate2.5g Sodium Oxybate administered during nap

Drug:Zolpidem5mg Zolpidem administered during nap

Drug:placeboPlacebo administered during nap

Study Arms

Research studies and clinical trials typically have two or more research arms. An arm is a group of people who receive the same treatment in the study.

Sodium Oxybate2.5g Sodium Oxybate administered during nap

Zolpidem5mg Zolpidem administered during nap

Placebo

Study Status

Unknown status

Start Date: October 2008

Completed Date:

Phase: N/A

Type: Interventional

Design:

Primary Outcome:

Secondary Outcome:

Study sponsors, principal investigator, and references

Principal Investigator:

Lead Sponsor: University of California, San Diego

Collaborator:

More information:https://clinicaltrials.gov/show/NCT00773032

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