Sleep | Memory Consolidation in Pharmacologically Enhanced Naps
Sleep research study
What is the primary objective of this study?
This study will examine whether various drugs affecting sleep cycles can improve different kinds of memory.
Who is eligible to participate?
Inclusion Criteria: - Speaks English - Resides in the general San Diego community - Completed at least 12 years of formal education, because education may affect performance on the cognitive task Exclusion Criteria: - No regular sleep-wake schedule, defined as not meeting study criteria or scoring between 31 and 69 on the Horne-Ostberg Morningness-Eveningness Questionnaire - Presence of a sleep disorder reported or detected on the questionnaires - Personal or immediate family (i.e., first degree relative) history of diagnosed significant psychopathology - Personal history of head injury with loss of consciousness for more than 15 minutes or with seizures - History of substance dependence - Current use of any psychotropic medications - Any cardiac, respiratory, or other medical condition that may affect cerebral metabolism - Noncorrectable vision and audition impairments
Which medical condition, disease, disorder, syndrome, illness, or injury is researched?
Interventions can include giving participants drugs, medical devices, procedures, vaccines, and other products that are either investigational or already available or noninvasive approaches such as surveys, education, and interviews.
Drug:Low-dose sodium oxybateParticipants will receive one dose of 2.5 g before each nap.
Drug:High-dose sodium oxybateParticipants will receive one dose of 3 g before each nap.
Drug:Low-dose zolpidemParticipants will receive one dose of 5 mg before each nap.
Drug:High-dose zolpidemParticipants will receive one dose of 10 mg before each nap.
Drug:PlaceboParticipants will receive a dose of placebo before each nap.
Research studies and clinical trials typically have two or more research arms. An arm is a group of people who receive the same treatment in the study.
Low-dose sodium oxybate
High-dose sodium oxybate
Start Date: September 2008
Completed Date: September 2015
Primary Outcome: Pharmacological enhancement of specific sleep parameters in a dose-dependent manner
Secondary Outcome: Correlation of pharmacological interventions with changes in sleep-stage-specific memory tasks
Study sponsors, principal investigator, and references
Principal Investigator: Sara C. Mednick, PhD
Lead Sponsor: University of California, San Diego
Collaborator: National Institute of Mental Health (NIMH)