Sleep | Memory Consolidation in Pharmacologically Enhanced Naps

Sleep research study

What is the primary objective of this study?

This study will examine whether various drugs affecting sleep cycles can improve different kinds of memory.

Who is eligible to participate?

Inclusion Criteria: - Speaks English - Resides in the general San Diego community - Completed at least 12 years of formal education, because education may affect performance on the cognitive task Exclusion Criteria: - No regular sleep-wake schedule, defined as not meeting study criteria or scoring between 31 and 69 on the Horne-Ostberg Morningness-Eveningness Questionnaire - Presence of a sleep disorder reported or detected on the questionnaires - Personal or immediate family (i.e., first degree relative) history of diagnosed significant psychopathology - Personal history of head injury with loss of consciousness for more than 15 minutes or with seizures - History of substance dependence - Current use of any psychotropic medications - Any cardiac, respiratory, or other medical condition that may affect cerebral metabolism - Noncorrectable vision and audition impairments

Which medical condition, disease, disorder, syndrome, illness, or injury is researched?


Study Interventions

Interventions can include giving participants drugs, medical devices, procedures, vaccines, and other products that are either investigational or already available or noninvasive approaches such as surveys, education, and interviews.

Drug:Low-dose sodium oxybateParticipants will receive one dose of 2.5 g before each nap.

Drug:High-dose sodium oxybateParticipants will receive one dose of 3 g before each nap.

Drug:Low-dose zolpidemParticipants will receive one dose of 5 mg before each nap.

Drug:High-dose zolpidemParticipants will receive one dose of 10 mg before each nap.

Drug:PlaceboParticipants will receive a dose of placebo before each nap.

Study Arms

Research studies and clinical trials typically have two or more research arms. An arm is a group of people who receive the same treatment in the study.

Low-dose sodium oxybate

High-dose sodium oxybate

Low-dose zolpidem

High-dose zolpidem


Study Status


Start Date: September 2008

Completed Date: September 2015

Phase: N/A

Type: Interventional


Primary Outcome: Pharmacological enhancement of specific sleep parameters in a dose-dependent manner

Secondary Outcome: Correlation of pharmacological interventions with changes in sleep-stage-specific memory tasks

Study sponsors, principal investigator, and references

Principal Investigator: Sara C. Mednick, PhD

Lead Sponsor: University of California, San Diego

Collaborator: National Institute of Mental Health (NIMH)

More information:

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