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Fibromyalgia | Lidocaine on Pain Relief and IL and Substance P in Fibromyalgia

Fibromyalgia research study

What is the primary objective of this study?

The study's primary objective is to evaluate the effect of intravenous lidocaine on pain and plasma interleukin-1 (IL-1), interleukin-6 (IL-6) and substance P in patients with fibromyalgia. As secondary objectives: evaluate the clinical manifestations, and plasma concentration of lidocaine.

Who is eligible to participate?

Inclusion Criteria: - Patients with fibromyalgia will be included in the study through the classification criteria proposed by the American College of Rheumatology (generalized hypersensitivity and pain or stiffness in 11 of 18 musculotendinous insertions sites for at least three months in the four quadrants of the body, absence of traumatic injury, rheumatic disease, neuromuscular or infectious arthropathy). Exclusion Criteria: - Will be excluded from the study patients who had: no cognitive or language comprehension; abnormal laboratory tests, trauma, psychiatric illness, rheumatic or neuromuscular another pain syndrome, infectious arthropathy, hypersensitivity to drugs and pregnant. Also will be excluded patients with arrhythmia, myocardial infarction, concomitant use of cisapride or monoamine oxidase inhibitor, bundle branch block or atrio-ventricular heart failure, acute, angle glaucoma, myasthenia gravis, severe liver disease and hyperthyroidism; and those who are using centrally acting analgesic medication (antidepressants, anticonvulsants, opioids, neuroleptics) for at least 4 weeks from baseline. Patients who experience severe side effects related to the infusion of lidocaine (severe hypotension and seizure) will be excluded from the study.

Which medical condition, disease, disorder, syndrome, illness, or injury is researched?

Fibromyalgia

Study Interventions

Interventions can include giving participants drugs, medical devices, procedures, vaccines, and other products that are either investigational or already available or noninvasive approaches such as surveys, education, and interviews.

Drug:LidocaineAfter completion of the inclusion criteria all patients receive a dose of amitriptyline 12.5 mg in the first week, and 25 mg in the eight subsequent weeks, orally, once daily at night. At lidocaine group 20 pacients will receive lidocaine at a dose of 4 mg / kg, not exceeding a dose of 240 mg diluted in 125ml of solution 0.9% saline.The solutions will be infused in 1 hour once a week in the four weeks following the start of the study..:Patients may use as additional analgesics up to 4g/day acetaminophen, and if necessary, they can use tramadol, recording the dose

Drug:lidocaineAfter completion of the inclusion criteria all patients receive a dose of amitriptyline 12.5 mg in the first week, and 25 mg in the eight subsequent weeks, orally, once daily at night. At saline group 20 pacients will receive 125ml of solution 0.9% saline.The solutions will be infused in 1 hour once a week in the four weeks following the start of the study. Patients may use as additional analgesics up to 4g/day acetaminophen, and if necessary, they can use tramadol, recording the dose

Study Arms

Research studies and clinical trials typically have two or more research arms. An arm is a group of people who receive the same treatment in the study.

LidocaineAfter completion of the inclusion criteria all patients receive a dose of amitriptyline 12.5 mg in the first week, and 25 mg in the eight subsequent weeks, orally, once daily at night. At lidocaine group 20 pacients will receive lidocaine at a dose of 4 mg / kg, not exceeding a dose of 240 mg diluted in 125ml of solution 0.9% saline.The solutions will be infused in 1 hour once a week in the four weeks following the start of the study..:Patients may use as additional analgesics up to 4g/day acetaminophen, and if necessary, they can use tramadol, recording the dose

SalineAfter completion of the inclusion criteria all patients receive a dose of amitriptyline 12.5 mg in the first week, and 25 mg in the eight subsequent weeks, orally, once daily at night. At saline group 20 pacients will receive 125ml of solution 0.9% saline.The solutions will be infused in 1 hour once a week in the four weeks following the start of the study. Patients may use as additional analgesics up to 4g/day acetaminophen, and if necessary, they can use tramadol, recording the dose

Study Status

Unknown status

Start Date: January 2010

Completed Date: December 2012

Phase: Phase 3

Type: Interventional

Design:

Primary Outcome: Evaluation of the effect of intravenous lidocaine on pain relief and plasma concentrations of interleukins (IL-1 and IL-6) and substance P in patients with fibromyalgia

Secondary Outcome:

Study sponsors, principal investigator, and references

Principal Investigator:

Lead Sponsor: Federal University of São Paulo

Collaborator:

More information:https://clinicaltrials.gov/show/NCT01391598

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