Neuropathic Pain Caused by Lumbar Radicular Pain | Effect of Minocycline on Pain Caused by Nerve Damage
Neuropathic Pain Caused by Lumbar Radicular Pain research study
What is the primary objective of this study?
The purpose of this study is to determine if minocycline is effective in the treatment of neuropathic pain. The effect of minocycline will be compared to the effect of placebo and amitriptyline.
Who is eligible to participate?
Inclusion Criteria: Lumbar radicular pain due to disc herniation, failed back surgery syndrome or spinal canal stenosis causing neuropathic pain Exclusion Criteria: 1. Diabetic, alcoholic or drug induced polyneuropathies 2. Depression or psychiatric comorbidity affecting pain sensation. 3. Use of antidepressants 4. Fibromyalgia and Chronic Fatigue Syndrome 5. Pregnancy. 6. Previous spinal cord damage 7. Malignancies 8. Allergy to minocycline or amitriptyline
Which medical condition, disease, disorder, syndrome, illness, or injury is researched?
Neuropathic Pain Caused by Lumbar Radicular Pain
Interventions can include giving participants drugs, medical devices, procedures, vaccines, and other products that are either investigational or already available or noninvasive approaches such as surveys, education, and interviews.
Drug:Minocycline100 mg once daily by mouth during 14 days
Drug:placeboonce daily by mouth during 14 days
Drug:Amitriptyline25mg once daily by mouth during 14 days
Research studies and clinical trials typically have two or more research arms. An arm is a group of people who receive the same treatment in the study.
PlaceboPlacebo, once daily
AmitriptylineAmitriptyline 25mg, once daily
MinocyclineMinocycline 100mg, once daily
Start Date: September 2011
Completed Date: August 2014
Phase: Phase 4
Primary Outcome: Pain intensity
Secondary Outcome: neuropathic pain diagnostic questionnaire (DN4) score
Study sponsors, principal investigator, and references
Principal Investigator: Jan Van Zundert, MD, PhD
Lead Sponsor: Ziekenhuis Oost-Limburg
Vanelderen P, Rouwette T, Kozicz T, Heylen R, Van Zundert J, Roubos EW, Vissers K. Effects of chronic administration of amitriptyline, gabapentin and minocycline on spinal brain-derived neurotrophic factor expression and neuropathic pain behavior in a rat chronic constriction injury model. Reg Anesth Pain Med. 2013 Mar-Apr;38(2):124-30. doi: 10.1097/AAP.0b013e31827d611b.
Bastos LF, de Oliveira AC, Watkins LR, Moraes MF, Coelho MM. Tetracyclines and pain. Naunyn Schmiedebergs Arch Pharmacol. 2012 Mar;385(3):225-41. doi: 10.1007/s00210-012-0727-1. Epub 2012 Jan 27. Review.
Zhang Q, Peng L, Zhang D. Minocycline may attenuate postherpetic neuralgia. Med Hypotheses. 2009 Nov;73(5):744-5. doi: 10.1016/j.mehy.2009.04.028. Epub 2009 May 24.
Sumracki NM, Hutchinson MR, Gentgall M, Briggs N, Williams DB, Rolan P. The effects of pregabalin and the glial attenuator minocycline on the response to intradermal capsaicin in patients with unilateral sciatica. PLoS One. 2012;7(6):e38525. doi: 10.1371/journal.pone.0038525. Epub 2012 Jun 7.