Childhood Acute Erythroleukemia (M6) | Identification of de Novo Fanconi Anemia in Younger Patients With Newly Diagnosed Acute Myeloid Leukemia
Childhood Acute Erythroleukemia (M6) research study
What is the primary objective of this study?
This research study is studying identification of de novo Fanconi anemia in younger patients with newly diagnosed acute myeloid leukemia. Studying samples of tissue from patients with cancer in the laboratory may help doctors identify and learn more about biomarkers related to Fanconi anemia in patients with acute myeloid leukemia.
Who is eligible to participate?
Inclusion Criteria: - Treated on COG-2961 or COG-AAML03P1 - At high risk of having Fanconi anemia, defined as meeting one the following groups of clinical criteria: - Group 1: Prolonged neutropenia after induction, severe regimen-related toxicity (mucositis, veno-occlusive disease, end-organ damage) - Group 2: Early non-relapse death (induction, consolidation) - Group 3: Small-for-weight, secondary malignancies
Which medical condition, disease, disorder, syndrome, illness, or injury is researched?
Childhood Acute Erythroleukemia (M6)
Childhood Acute Megakaryocytic Leukemia (M7)
Childhood Acute Minimally Differentiated Myeloid Leukemia (M0)
Childhood Acute Monoblastic Leukemia (M5a)
Childhood Acute Monocytic Leukemia (M5b)
Childhood Acute Myeloblastic Leukemia With Maturation (M2)
Childhood Acute Myeloblastic Leukemia Without Maturation (M1)
Childhood Acute Myelomonocytic Leukemia (M4)
Childhood Myelodysplastic Syndromes
Chronic Myelomonocytic Leukemia
de Novo Myelodysplastic Syndromes
Refractory Anemia With Excess Blasts
Refractory Anemia With Excess Blasts in Transformation
Refractory Anemia With Ringed Sideroblasts
Secondary Myelodysplastic Syndromes
Untreated Childhood Acute Myeloid Leukemia and Other Myeloid Malignancies
Interventions can include giving participants drugs, medical devices, procedures, vaccines, and other products that are either investigational or already available or noninvasive approaches such as surveys, education, and interviews.
Other:laboratory biomarker analysisCorrelative studies
Research studies and clinical trials typically have two or more research arms. An arm is a group of people who receive the same treatment in the study.
Ancillary-correlativePreviously collected cryopreserved cells are analyzed via western blot to identify patients with Fanconi anemia.
Start Date: May 2009
Completed Date: May 2016
Primary Outcome: Identification of children at high risk of having Fanconi anemia
Study sponsors, principal investigator, and references
Principal Investigator: Monica Thakar, MD
Lead Sponsor: Children's Oncology Group
Collaborator: National Cancer Institute (NCI)