PatientsVille.com LogoPatientsVille.com

Iron-Deficiency Anemias, | The Purpose of the Study is to Examine Whether Iron Deficiency Anemia is Associated With Increased Production of Thrombin and Whether Correction of Anemia by Providing Iron Intravenously Causes a Significant Reduction in Production of Thrombin.

Iron-Deficiency Anemias, research study

What is the primary objective of this study?

In total 50 subjects with iron deficiency anemia treated with intravenous iron are planned for inclusion in this trial. After signing an informed consent a blood sample will be obtained from each participant before iron treatment. The investigators will measure the thrombin generation in plasma assessed by the calibrated automated thrombogram (CAT). patient will go face to face interview and will be asked to answer structured questionnaire which will include information on demographics, clinical data ( fever, allergies , etc.) and comorbidities Two weeks after completing intravenous iron administration additional blood samples will be taken: thrombin generation will be measured

Who is eligible to participate?

Inclusion Criteria: - age >18 years - Iron deficiency anemia that did not response to oral iron treatment and is planned to receive iron supplement intravenously. - Signing the informed consent exclusion criteria: - chronic inflammatory disease - renal failure - Malignancy - Infectious disease - Other reason for anemia except iron deficiency anemia. - Pregnant women - Use of anti aggregating agents or anticoagulants

Which medical condition, disease, disorder, syndrome, illness, or injury is researched?

Iron-Deficiency Anemias,

Study Interventions

Interventions can include giving participants drugs, medical devices, procedures, vaccines, and other products that are either investigational or already available or noninvasive approaches such as surveys, education, and interviews.

Study Arms

Research studies and clinical trials typically have two or more research arms. An arm is a group of people who receive the same treatment in the study.

Study Status

Completed

Start Date: October 2013

Completed Date: December 2015

Phase: N/A

Type: Observational [Patient Registry]

Design:

Primary Outcome: thrombin generation levels

Secondary Outcome:

Study sponsors, principal investigator, and references

Principal Investigator:

Lead Sponsor: HaEmek Medical Center, Israel

Collaborator:

More information:https://clinicaltrials.gov/show/NCT02129907

Discuss Anaemia