Emotions | Study of the Effects of Negative Emotions on Endothelial Function
Emotions research study
What is the primary objective of this study?
Study aims and hypotheses are as follows: Primary Hypotheses: Compared to the neutral condition, the anger recall task will acutely induce endothelial dysfunction by impairing endothelium-dependent arterial vasodilation (Hypothesis 1a); increasing circulating levels of EC-derived microparticles (EMPs), a marker of EC injury (Hypothesis 1b); and reducing circulating levels of bone marrow-derived endothelial progenitor cells (EPCs), a marker of EC reparative capacity (Hypothesis 1c). Secondary Hypotheses: Compared to the neutral condition, the depressed mood and separately the anxiety recall tasks will acutely impair endothelium-dependent arterial vasodilation, increase circulating levels of EMPs, and reduce circulating levels of bone marrow-derived EPCs. There will be a relation of the level of self-reported anger, depressed mood, and anxiety with endothelial dysfunction.
Who is eligible to participate?
Inclusion Criteria: - Age 18 and over - Fluent in English Exclusion Criteria: - History of any chronic medical condition including prevalent CVD and traditional risk factors - Active smoking - Chronic medication use, including over-the-counter drugs or herbal medications - History of psychosis, a mood disorder, or any overt personality disorder - Latex allergy - Poor peripheral veins with low possibility of getting IV access
Which medical condition, disease, disorder, syndrome, illness, or injury is researched?
Interventions can include giving participants drugs, medical devices, procedures, vaccines, and other products that are either investigational or already available or noninvasive approaches such as surveys, education, and interviews.
Other:Anger InductionThe participant is asked to recall an incident in the recent past during which they became moderately to extremely angry, or is asked to read statements out loud evoking moderate to extreme feelings of anger. The participant is asked to take a few moments to bring the details of the incident to mind and, when ready, to describe the incident in great detail to the experimenter. Participants are asked to describe key elements, such as any dialogue that transpired during the incident, along with other details of the incident, particularly regarding the feelings of that particular emotion experienced at the time. In so doing, the experimenter works to re-elicit the emotions that accompanied the original incident. The duration of the negative emotion induction task is 8 minutes.
Other:Depressed Mood InductionThe participant will be asked to undergo a validated depression/sadness induction task.
Other:Anxiety InductionThe participant will be asked to undergo a validated anxiety induction task.
Other:Neutral emotion taskThis is a neutral control task that each of the negation emotion induction tasks will be compared to.
Research studies and clinical trials typically have two or more research arms. An arm is a group of people who receive the same treatment in the study.
Anger inductionThe participant will be asked to undergo a validated anger induction task.
Depressed Mood InductionThe participant will be asked to undergo a validated depression/sadness induction task.
Anxiety InductionThe participant will be asked to undergo a validated anxiety induction task.
Neutral emotion taskThe participant will be asked to undergo a validated neutral task (i.e. count aloud by ones, starting with one and ending with 100, over and over, until the task period has ended).
Active, not recruiting
Start Date: September 1, 2013
Completed Date: June 2018
Primary Outcome: Endothelium-dependent arterial vasodilation
Secondary Outcome: Circulating EMPs expressing CD31
Study sponsors, principal investigator, and references
Principal Investigator: Daichi Shimbo, MD
Lead Sponsor: Columbia University
Collaborator: National Heart, Lung, and Blood Institute (NHLBI)