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Retinal Detachment | Postoperative Pain Control Following Vitreoretinal Surgery

Retinal Detachment research study

What is the primary objective of this study?

The aim of this study is to evaluate if patients receiving a steroid (triamcinolone acetonide) combined with local anesthesia and antibiotic following retina surgery have better postoperative pain control those receiving local anesthesia and antibiotic alone.

Who is eligible to participate?

Inclusion Criteria: - Patients undergoing vitreoretinal surgery at the Emory Eye Center Ambulatory Surgery Center and Emory University Hospital by retina attending faculty surgeons Exclusion Criteria: - Unable to verbalize level of pain control - Pediatric patients (<18 years old) - Glaucoma, ocular hypertension, or glaucoma suspects - Allergy to local anesthetic - Pre-existing chronic pain requiring narcotic pain medication - Drug addiction - Impaired periorbital sensation (history of herpes simplex, zoster, corneal graft)

Which medical condition, disease, disorder, syndrome, illness, or injury is researched?

Retinal Detachment

Proliferative Vitreoretinopathy

Retinoschisis

Study Interventions

Interventions can include giving participants drugs, medical devices, procedures, vaccines, and other products that are either investigational or already available or noninvasive approaches such as surveys, education, and interviews.

Drug:TriamcinoloneRetrobulbar anesthesia

Drug:Bupivicaine HydrochlorideRetrobulbar anesthesia

Study Arms

Research studies and clinical trials typically have two or more research arms. An arm is a group of people who receive the same treatment in the study.

Retrobulbar anesthesia with Bupivicaine Hydrochloride and Triamcinolone Acetonide

BupivicaineRetrobulbar anesthesia with Bupivicaine Hydrochloride

Study Status

Completed

Start Date: July 2012

Completed Date: December 2015

Phase: Phase 4

Type: Interventional

Design:

Primary Outcome: Mean Pain Score

Secondary Outcome: Mean Acetaminophen Intake

Study sponsors, principal investigator, and references

Principal Investigator: Timothy W Olsen, MD

Lead Sponsor: Emory University

Collaborator:

More information:https://clinicaltrials.gov/show/NCT01995045

Gioia L, Prandi E, Codnotti M, Casati A,et al Peribulbar anesthesia with either 0.75% ropivacaine or a 2% lidocaine and 0.5% bupivacaine mixture for vitreoretinal surgery: a double-blinded study. Anesth Analg(89: 739-742, 1999. Shende D, Sadhasivam S, Madan R. Effects of peribulbar bupivacaine as an adjunct to general anaesthesia on peri-operative outcome following retinal detachment surgery. Anaesthesia(55): 970-975, 2000. Morel J, Pascal J, Charier D, et al. Preoperative peribulbar block in patients undergoing retinal detachment surgery under general anesthesia: a randomized double-blind study. Anesth Analg (102): 1082-1087, 2006. Ghali AM, Btarny AM. The effect on outcome of peribulbar anesthesia in conjunction with general anesthesia for vitreoretinal surgery. Anaesthesia (65): 249-253, 2010. Chavan SB, Cummings EJ.

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