Atrophy | Muscle Atrophy in Sepsis
Atrophy research study
What is the primary objective of this study?
Severe sepsis will provoke signals leading to muscle atrophy and weakness. Electrical stimulation will reduce the impact of sepsis.
Who is eligible to participate?
Inclusion Criteria: - Severe sepsis for < 72hr
Which medical condition, disease, disorder, syndrome, illness, or injury is researched?
Interventions can include giving participants drugs, medical devices, procedures, vaccines, and other products that are either investigational or already available or noninvasive approaches such as surveys, education, and interviews.
Research studies and clinical trials typically have two or more research arms. An arm is a group of people who receive the same treatment in the study.
Start Date: December 2007
Completed Date: December 2009
Primary Outcome: Electrical stimulation will be associated with upregulation of anabolic signaling molecules and genes, downregulation of catabolic signaling molecules and genes within skeletal muscle of patients with sepsis
Secondary Outcome: Electrical stimulation will be associated with improvement of histologic and electrophysiologic and strength parameters within skeletal muscle of patients with sepsis
Study sponsors, principal investigator, and references
Lead Sponsor: Gregory A. Schmidt