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Critical Illness Myopathy | ICU Acquired Neuromyopathy and Diaphragm Function

Critical Illness Myopathy research study

What is the primary objective of this study?

Critical illness neuromyopathy is a common disease acquired during ICU stay leading to a deep weakness involving the respiratory muscle work which result in a delayed weaning of mechanical ventilation. The main objective is to quantify the loss of diaphragm function by measuring the diaphragm force (using the non invasive method by phrenic nerve stimulation allowing to measure the twitch airway pressure during airway occlusion) in a selected population of patients with critical illness neuromyopathy (defined as a MRC score < 48). The second end points are to evaluate its incidence, the consequences on the patients outcome (extubation success or failure; ICU stay) and to evaluate the relations between diaphragm function (twitch airway pressure during airway occlusion, maximal inspiratory pressure and diaphragm thickness evaluated by ultrasound) and peripheral limbs force (evaluated by the Medical Research Council - MRC score).

Who is eligible to participate?

Inclusion Criteria: - MRC score <48 - ready for weaning from mechanical ventilation Exclusion Criteria: - previous history of neuromyopathy - impossibility to perform a magnetic stimulation - cervical spine injury - bihemispheric or brain stem lesion

Which medical condition, disease, disorder, syndrome, illness, or injury is researched?

Critical Illness Myopathy

Respiratory Paralysis

Study Interventions

Interventions can include giving participants drugs, medical devices, procedures, vaccines, and other products that are either investigational or already available or noninvasive approaches such as surveys, education, and interviews.

Other:Non invasive phrenic nerve stimulationNon invasive phrenic nerve stimulation allowing to measure the twitch airway pressure during airway occlusion

Study Arms

Research studies and clinical trials typically have two or more research arms. An arm is a group of people who receive the same treatment in the study.

Critical illness neuromyopthyNon invasive phrenic nerve stimulation allowing to measure the twitch airway pressure during airway occlusion

Study Status

Completed

Start Date: May 2013

Completed Date: November 2013

Phase: N/A

Type: Observational

Design:

Primary Outcome: Twitch tracheal pressure during airway occlusion (expressed in cmH2O)

Secondary Outcome: extubation success (defined as no need reintubation during the 48h after extubation)

Study sponsors, principal investigator, and references

Principal Investigator: Samir Jaber, MD PhD

Lead Sponsor: University Hospital, Montpellier

Collaborator:

More information:https://clinicaltrials.gov/show/NCT01968889

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