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Asthma | Inflammatory Mediators and microRNA Analysis in Premenstrual Asthma

Asthma research study

What is the primary objective of this study?

A small number of women with asthma have an increase in asthma symptoms during the premenstrual or menstrual period. This study is being done to investigate the possible causes of this premenstrual increase in asthma symptoms and to help asthma care providers identify those patients who may suffer from this condition.

Who is eligible to participate?

Inclusion Criteria: - Diagnosis of asthma Exclusion Criteria: - Are pregnant - Take hormonal medication - Have an illness with fever (> 38.0 ˚ C or 100.4 ˚ F) within 24 hours of Visit 1 or between Visits 1 and 2 - Are participating in another interventional research trial - Have other major chronic illnesses that would interfere with participation - Are taking the following medications: leukotriene receptor antagonists, oral steroids, anticoagulants, or insulin - Are unable to provide consent

Which medical condition, disease, disorder, syndrome, illness, or injury is researched?

Asthma

Study Interventions

Interventions can include giving participants drugs, medical devices, procedures, vaccines, and other products that are either investigational or already available or noninvasive approaches such as surveys, education, and interviews.

Study Arms

Research studies and clinical trials typically have two or more research arms. An arm is a group of people who receive the same treatment in the study.

premenstual asthmawomen with asthma have an increase in asthma symptoms during the premenstrual or menstrual period

Study Status

Recruiting

Start Date: February 2009

Completed Date: December 2020

Phase:

Type: Observational

Design:

Primary Outcome: To determine the patterns of serum microRNA in asthmatic women with premenstrual asthma and asthmatic women without premenstrual asthma at baseline and during the premenstrual period

Secondary Outcome: To determine the level of exhaled nitric oxide and serum leukotrienes B4 (LTB4) and C4 (LTC4) in asthmatic women with premenstrual asthma and asthmatic women without premenstrual asthma at baseline and during the premenstrual period

Study sponsors, principal investigator, and references

Principal Investigator: Jennifer McCallister, MD

Lead Sponsor: Ohio State University

Collaborator:

More information:https://clinicaltrials.gov/show/NCT00837395

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