Peritonsillar Abscess | Assessing the Necessity of Prescribing Antibiotics (Clavulin or Clindamycin Versus Placebo) Post-peritonsillar Abscess Drainage
Peritonsillar Abscess research study
What is the primary objective of this study?
This study aims to look at the necessity for prescribing antibiotics post-drainage of peritonsillar abscesses (PTA). This will be a single-blinded randomized-control trial with two arms - patients receiving placebo versus those receiving a seven day course of oral Amoxicillin-Clavulanic acid. The main objective measure will be to assess if there is resolution of the peri-tonsillar abscess and there has been no reaccumulation. Patients will be blinded to whether they receive placebo or amoxicillin-clavulanic acid. Patients will be phoned after 7 days to assess if their symptoms have resolved via an over the phone questionnaire. Anaerobic and aerobic cultures will be obtained.
Who is eligible to participate?
Inclusion Criteria: - Older than 18 years of age - Diagnosed with a peritonsillar abscess that has been drained and purulence has been obtained Exclusion Criteria: - Pregnant - Under the age of 18 - Bilateral peritonsillar abscesses - Recently drained peritonsillar abscess - Immunocomprimised
Which medical condition, disease, disorder, syndrome, illness, or injury is researched?
Interventions can include giving participants drugs, medical devices, procedures, vaccines, and other products that are either investigational or already available or noninvasive approaches such as surveys, education, and interviews.
Drug:ClavulinPatients will be randomized to the antibiotic or placebo arm via a random number generator.
Drug:Randomization to PlaceboPatient's post-drainage of antibiotics will receive placebo and not receive antibiotics
Drug:ClindamycinPatients will be randomized to the antibiotic or placebo arm via a random number generator
Research studies and clinical trials typically have two or more research arms. An arm is a group of people who receive the same treatment in the study.
Antibiotic Clavulin or ClindamycinPatient's in this arm are randomized by random-number generator to receive antibiotics. This is for a 7 day course of antibiotics. Those that are allergic to penicillin will receive clindamycin. Randomization occurs after knowledge of the patient's allergy status.
PlaceboPatient's randomized to this arm post-drainage will receive placebo and not receive antibiotics
Start Date: June 2012
Completed Date: June 2014
Primary Outcome: Re-accumulation of the patient's peri-tonsillar abscess
Study sponsors, principal investigator, and references
Principal Investigator: Murad Husein, MD. FRCSC
Lead Sponsor: Lawson Health Research Institute