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Bladder Cancer | Biomarker Identification for Bladder Cancer Patients

Bladder Cancer research study

What is the primary objective of this study?

To develop a simple blood and urine test that we would perform before patients start their treatment to predict the risk that their bladder cancer might come back. To develop this test the investigators plan to analyze blood, urine and cancer tissue from bladder cancer patients and follow them closely during and after treatment. This will include looking for changes in proteins and genes that might play a role in bladder cancer biology. The investigators will then compare the information obtained from the studies of blood, urine and cancer tissue between patients that are cured and those whose cancer comes back. The knowledge about these differences between patients can then potentially be used to develop a blood or urine test to tell us who has a high risk for having bladder cancer come back.

Who is eligible to participate?

Inclusion Criteria: - Adult patients ≥18 years old. - Patients suspected, clinically diagnosed, or histologically diagnosed bladder cancer. - Patients undergoing cystoscopy without cancer suspicion. - Ability to give an informed consent. Exclusion Criteria: - Patients receiving concurrent therapy for a second malignancy. - < 18 years old. - Inability to give an informed consent.

Which medical condition, disease, disorder, syndrome, illness, or injury is researched?

Bladder Cancer

Study Interventions

Interventions can include giving participants drugs, medical devices, procedures, vaccines, and other products that are either investigational or already available or noninvasive approaches such as surveys, education, and interviews.

Procedure:Sample CollectionA collection of donated cancer and normal adjacent tissues, blood and urine which will be prospectively obtained from patients through the Tissue Procurement Shared Resources (TPSR) and The Ohio State University Comprehensive Cancer Center Biospecimen and Biorepository Resource (BBR) as needed.

Study Arms

Research studies and clinical trials typically have two or more research arms. An arm is a group of people who receive the same treatment in the study.

Bladder Cancer PatientsPatients with muscle invasive bladder cancer. A sample collection of donated cancer and normal adjacent tissues, blood and urine which will be prospectively obtained from patients through the Tissue Procurement Shared Resources (TPSR) and The Ohio State University Comprehensive Cancer Center Biospecimen and Biorepository Resource (BBR) as needed.

Study Status

Unknown status

Start Date: January 21, 2014

Completed Date: November 30, 2018

Phase:

Type: Observational

Design:

Primary Outcome: Identify novel biomarkers for bladder cancer

Secondary Outcome:

Study sponsors, principal investigator, and references

Principal Investigator: Arna Chakravarti, MD

Lead Sponsor: Ohio State University Comprehensive Cancer Center

Collaborator:

More information:https://clinicaltrials.gov/show/NCT02053662

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