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Transfusion | Standard Issue Transfusion Versus Fresher Red Blood Cell Use in Intensive Care- A Randomised Controlled Trial

Transfusion research study

What is the primary objective of this study?

In Australia, blood for transfusion has a \"use by\" date of 42 days after collection. The actual age of blood given to patients depends on what is available at the time and the rate of usage. During the last decade, it has been reported that blood transfusion in patients admitted to intensive care was associated with an independent increase of mortality. Some research suggests that transfusion of fresher blood might help patients in the intensive care unit to reach a better recovery. This project will test whether patients who receive 'fresher' blood do better than patients who receive 'standard issue' blood.

Who is eligible to participate?

Inclusion Criteria: - Patients hospitalised in ICU with an anticipated ICU stay of at least 24 hours, in whom the decision has been made by medical staff to transfuse at least one RBC unit. Exclusion Criteria: - Age younger than 18 - Previous RBC transfusion during the current hospital admission (including transfusion in another hospital for transferred patients) - Diagnosis of transplantation or hematologic diseases - Pregnancy - Cardiac surgery during the present hospital admission - Expected to die imminently (<24hrs) - The treating physician believes it is not in the best interest of the patient to be randomised in this trial. - Known objection to the administration of human blood products - Participation in a competing study (see below)

Which medical condition, disease, disorder, syndrome, illness, or injury is researched?

Transfusion

Age of Blood

Study Interventions

Interventions can include giving participants drugs, medical devices, procedures, vaccines, and other products that are either investigational or already available or noninvasive approaches such as surveys, education, and interviews.

Other:Blood transfusionBlood transfusion in ICU patients aged 18 and over.

Study Arms

Research studies and clinical trials typically have two or more research arms. An arm is a group of people who receive the same treatment in the study.

Standard of careBlood Transfusion Standard of care- oldest blood.

Arm BBlood Transfusion Freshest blood.

Study Status

Completed

Start Date: October 2012

Completed Date: June 2017

Phase: Phase 3

Type: Interventional

Design:

Primary Outcome: Mortality

Secondary Outcome: Mortality

Study sponsors, principal investigator, and references

Principal Investigator: D. James Cooper, A.O., M.D.

Lead Sponsor: Australian and New Zealand Intensive Care Research Centre

Collaborator: Australian Red Cross

More information:https://clinicaltrials.gov/show/NCT01638416

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