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Heart Failure | Choosing the Right Pacing Mode in Heart Failure - The CHOICE Trial

Heart Failure research study

What is the primary objective of this study?

The aim of the study is to see if biventricular pacemakers offer any advantage over conventional pacemakers in patients with heart failure who require pacemakers. The endpoints will be the 6 minute walking distance along with markers of cardiovascular function. The investigators' hypothesis is that biventricular pacing is preferable to conventional pacing in these heart failure patients.

Who is eligible to participate?

Inclusion Criteria: 1. Left ventricular systolic dysfunction. 2. Atrio-ventricular node disease. 3. Anticipated to be more than 40% paced, (including patients in permanent atrial fibrillation). 4. Ability to walk independently (walking aid permitted). Exclusion Criteria: 1. Patients meeting criteria for CRT by current guidelines will be excluded. 2. Life expectancy less than12 months. 3. Inability to walk independently. 4. Patients not likely to be compliant with follow-up. 5. Bradyarrhythmia due with sino-atrial disease only.

Which medical condition, disease, disorder, syndrome, illness, or injury is researched?

Heart Failure

Study Interventions

Interventions can include giving participants drugs, medical devices, procedures, vaccines, and other products that are either investigational or already available or noninvasive approaches such as surveys, education, and interviews.

Device:Bi Ventricular Pacing

Device:Right Ventricular Pacing

Study Arms

Research studies and clinical trials typically have two or more research arms. An arm is a group of people who receive the same treatment in the study.

1Biventricular Pacing

2Right Ventricular Pacing

Study Status

Completed

Start Date: September 2009

Completed Date: January 2011

Phase: N/A

Type: Interventional

Design:

Primary Outcome: 6 minute hall walk test

Secondary Outcome: Endothelial Function

Study sponsors, principal investigator, and references

Principal Investigator:

Lead Sponsor: University of Dundee

Collaborator: Chest, Heart and Stroke Association Scotland

More information:https://clinicaltrials.gov/show/NCT00875732

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