Bradyarrhythmia | Identify the Genes Polymorphisms Related to Non-familial Bradyarrhythmia

Bradyarrhythmia research study

What is the primary objective of this study?

Bradyarrhythmia, including sinus node dysfunction and atrioventricular block, is a major cause necessitating pacemaker implantation. In contrast to familial bradyarrhythmia known as by mutations at particular ion channels, limited information is available for the mechanistic study in non-familial bradyarrhythmia. Possible gene polymorphisms related to non-familial bradyarrhythmia were studied. Comparison of multi-locus analysis and single-locus analysis will be analyzed between the cases and controls. Functional studies will perform to clarify the results of association study.

Who is eligible to participate?

Inclusion Criteria: - The patients with non-familial bradyarrhythmia Exclusion Criteria: - Familial bradyarrhythmia Reversible bradyarrhythmia Bradyarrhythmia after open heart surgery and severe organic heart diseases

Which medical condition, disease, disorder, syndrome, illness, or injury is researched?


Study Interventions

Interventions can include giving participants drugs, medical devices, procedures, vaccines, and other products that are either investigational or already available or noninvasive approaches such as surveys, education, and interviews.

Study Arms

Research studies and clinical trials typically have two or more research arms. An arm is a group of people who receive the same treatment in the study.

sinus node dysfunction

Atrioventricular block


Study Status

Unknown status

Start Date: February 2011

Completed Date:


Type: Observational


Primary Outcome:

Secondary Outcome:

Study sponsors, principal investigator, and references

Principal Investigator: Jan-Yow Chen, MD

Lead Sponsor: China Medical University Hospital

Collaborator: China Medical University, China

More information:

Mangrum JM, DiMarco JP. The evaluation and management of bradycardia. N Engl J Med. 2000 Mar 9;342(10):703-9. Review.

Discuss Bradycardia