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Bradycardia During Pulling of Eyeball | Autonomic Nervous System Activity and Oculocardiac Reflex.

Bradycardia During Pulling of Eyeball research study

What is the primary objective of this study?

Pulling the eyeball during ophthalmic surgery provokes decrease in heart rate. This phenomenon is called oculocardiac reflex. In some patients asystole may occur. Other cardiac features of this reflex include hypotension, dysrhythmias, atrioventricular block. These cardiovascular disturbances may lead to decreased perfusion and ischemia of vital organs. Patients with existing cardiovascular disease are in risk of complications. Cardiovascular system is mainly innervated with autonomic nervous system (ANS). Sympathetic/parasympathetic activity may be determined by Heart Rate Variability (HRV). HRV analysis based on short 5 minutes electrocardiography has been found useful for prediction of hypotension and bradycardia during induction of general anaesthesia and during spinal block. The aim of this study is to verify whether it is possible to predict oculocardiac reflex with the use of HRV analysis for ANS activity assessment, measured prior to the ophthalmic surgery.

Who is eligible to participate?

Inclusion Criteria: - planned surgery - over 18 years of age - surgery under general anaesthesia Exclusion Criteria: - urgent surgery - under 18 years of age and over 65 - patients with generalised, nontreated disease - patients receiving beta blockers or calcium channel blocker - diabetic patients - patients operated under peri or retrobulbar anaesthesia

Which medical condition, disease, disorder, syndrome, illness, or injury is researched?

Bradycardia During Pulling of Eyeball

Study Interventions

Interventions can include giving participants drugs, medical devices, procedures, vaccines, and other products that are either investigational or already available or noninvasive approaches such as surveys, education, and interviews.

Study Arms

Research studies and clinical trials typically have two or more research arms. An arm is a group of people who receive the same treatment in the study.

Study Status

Recruiting

Start Date: April 2009

Completed Date: December 2018

Phase: N/A

Type: Observational

Design:

Primary Outcome: oculocardiac reflex occurence in relation to autonomic system activity

Secondary Outcome:

Study sponsors, principal investigator, and references

Principal Investigator: Magdalena A Wujtewicz, MD PhD

Lead Sponsor: Medical University of Gdansk

Collaborator:

More information:https://clinicaltrials.gov/show/NCT01714362

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