Chest Pain | ProspEctive First Evaluation in Chest Pain Trial

Chest Pain research study

What is the primary objective of this study?

The purpose of this study is to determine the best initial test in patients admitted to the hospital complaining of chest pain.

Who is eligible to participate?

Inclusion Criteria: - Patients with chest pain or SOB admitted for rule out acute coronary syndrome - Age ≥45 years - EKG non-diagnostic for acute coronary syndrome - At least 1 set of negative troponin I Exclusion Criteria: - Patient with ST elevation myocardial infarction. - Patients with non-ST elevation myocardial infarction. - Patients with known CAD. - Patients with serum creatinine > 1.5. - Atrial fibrillation or marked irregular heart rhythm. - Patients in whom heart rate cannot be controlled. - Patient with allergies to iodinated contrast agents. - Pregnant women - Patients unable to give informed consent

Which medical condition, disease, disorder, syndrome, illness, or injury is researched?

Chest Pain

Shortness of Breath

Suspected Acute Coronary Syndrome

Study Interventions

Interventions can include giving participants drugs, medical devices, procedures, vaccines, and other products that are either investigational or already available or noninvasive approaches such as surveys, education, and interviews.

Procedure:Coronary CT AngiographyCCTA

Procedure:Stress TestStress Test

Study Arms

Research studies and clinical trials typically have two or more research arms. An arm is a group of people who receive the same treatment in the study.

Coronary CT AngiographyPatient admitted with chest pain is randomized to CCTA for assessment.

Stress TestPatients admitted with chest pain are randomized to a stress test (stress SPECT or Echocardiography) for assessment.

Study Status


Start Date: September 2011

Completed Date: December 2015

Phase: N/A

Type: Interventional


Primary Outcome: Time to discharge

Secondary Outcome: All-cause mortality

Study sponsors, principal investigator, and references

Principal Investigator: Seth Uretsky, MD

Lead Sponsor: St. Luke's-Roosevelt Hospital Center


More information:

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