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ICU Patients | Syndrome and Aspiration Pneumonia in Intensive Care

ICU Patients research study

What is the primary objective of this study?

Inhalation is a common condition in patients with impaired their awareness requiring protection of the upper airway by endotracheal intubation. This inhalation may lead to chemical pneumonitis and/or bacterial pneumonia. Only the latter requires the administration of antibiotics. Patients developing such a bacterial pneumonia, has a mortality, duration of mechanical ventilation and length of ICU stay increased. However, the proportion of patients with such bacterial pneumonia, bacterial ecology and morbidity that are little known. The aim of this study is to determine the frequency of bacterial pneumonia in patients admitted to the ICU for coma and treated with mechanical ventilation

Who is eligible to participate?

Inclusion Criteria: - Altered consciousness defined by a Glasgow Coma Scale score less than or equal to 8 before protection of the upper airway by endotracheal intubation - Patient under mechanical ventilation Exclusion Criteria: - Patient with pre-existing impairment of laryngeal function in Parkinson's disease, Alzheimer's disease, amyotrophic lateral sclerosis, laryngeal cancer, radiotherapy laryngeal - Patient under guardianship - Inpatient without consent - Pregnant woman - Patient previously treated with antibiotics for more than 24 hours at the time of ICU admission - Patient with infection at ICU admission which justified probabilist antibiotic treatment - Lack of social security - Refusal of the patient or their next of kind

Which medical condition, disease, disorder, syndrome, illness, or injury is researched?

ICU Patients

Under Mechanical Ventilation

In State of Coma (Define by Glasgow ≤ 8)

No Antibiotic Treatment

Study Interventions

Interventions can include giving participants drugs, medical devices, procedures, vaccines, and other products that are either investigational or already available or noninvasive approaches such as surveys, education, and interviews.

Study Arms

Research studies and clinical trials typically have two or more research arms. An arm is a group of people who receive the same treatment in the study.

Coma patients in ICU under mechanical ventilation

Study Status

Completed

Start Date: November 2012

Completed Date: April 2015

Phase: N/A

Type: Observational

Design:

Primary Outcome: Determine the frequency of bacterial pneumonia in patients admitted to the ICU for coma and treated with mechanical ventilation

Secondary Outcome: Quantify the use of antibiotics during the ICU stay for patients admitted to the ICU for coma and treated with mechanical ventilation

Study sponsors, principal investigator, and references

Principal Investigator: Jean Baptiste Lascarrou, MD

Lead Sponsor: Centre Hospitalier Departemental Vendee

Collaborator:

More information:https://clinicaltrials.gov/show/NCT01881672

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