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Brain Death | Special Imaging Technique to Aid in the Diagnosis of Patients in Coma After Cardiac Arrest

Brain Death research study

What is the primary objective of this study?

In the present pilot study, the investigators propose to determine if performing CT perfusion scans in post-cardiac arrest patients in coma will help prognosticate the outcome in these patients.

Who is eligible to participate?

Inclusion Criteria: - All adult patients (age range: 18-80 years), in a coma for at least 24 hours following cardiac arrest who are admitted to our cardiac intensive care unit and who have recovered body temperature back to normal after being subjected to the therapeutic hypothermia protocol will be included in the study. - Also included are those patients whose next of kin have provided consent for the study. Exclusion Criteria: - patients who are pregnant, - those with impaired renal function, - those who have contraindications to the CT contrast media (such as a known allergy or anaphylactic reactions) and - those who do not provide consent. Pregnant patients will be excluded to avoid any potential adverse effect of radiation from CT perfusion study on the developing foetus. A developing foetus is more vulnerable to radiation when compared to adult patients. Patients above 80 years will be excluded to avoid age related comorbidities affecting the patients' survival. We do not see patients below 18 years of age at our institution thus they will be excluded.

Which medical condition, disease, disorder, syndrome, illness, or injury is researched?

Brain Death

Study Interventions

Interventions can include giving participants drugs, medical devices, procedures, vaccines, and other products that are either investigational or already available or noninvasive approaches such as surveys, education, and interviews.

Procedure:Computed tomography perfusionComputed tomography perfusion of the head

Study Arms

Research studies and clinical trials typically have two or more research arms. An arm is a group of people who receive the same treatment in the study.

Computed tomography perfusionParticipants will undergo CT perfusion of the head after cooling following cardiac arrest.

Study Status

Recruiting

Start Date: May 2014

Completed Date: December 2016

Phase: N/A

Type: Interventional

Design:

Primary Outcome: Clinical evaluation of brainstem function

Secondary Outcome: Number of adverse events as a measure of safety and tolerability

Study sponsors, principal investigator, and references

Principal Investigator: Jai JS Shankar, MD, DM

Lead Sponsor: Nova Scotia Health Authority

Collaborator:

More information:https://clinicaltrials.gov/show/NCT02102945

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