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Attention Deficit Hyperactivity Disorder | Methylphenidate on Intracortical Inhibition in Methamphetamine Abusers Attention Deficit Hyperactivity Disorder (ADHD)

Attention Deficit Hyperactivity Disorder research study

What is the primary objective of this study?

Previous studies using transcranial magnetic stimulation (TMS) with paired pulse protocols have shown that a conditioning TMS pulse applied to the human motor cortex changes the excitability of motor pathways from the motor cortex to spinal motorneurons. These effects depended on the stimulus intensity of both conditioning and test pulse and also the ISI). A characteristical sequence of inhibition (short interval cortical inhibition [SICI], GABA-Aerg), facilitation (intracortical facilitation [ICF]), and inhibition again (long interval cortical inhibition [LICI], GABA-Berg) is thought to be physiologically involved in motor control. Previous studies have also shown that neuronal inhibitory motor circuits are also disturbed in ADHD which will be restored by using methylphenidate. In this study the investigators sought to investigate if methamphetamine abuse (from the same chemical class of medications) will alter such effects of methylphenidate.

Who is eligible to participate?

Inclusion Criteria: - DSM-IV diagnosis of Methamphetamine abuse co morbid with ADHD - Right handedness Exclusion Criteria: - Other current Axis I disorders (except simple phobia and nicotine addiction) - Personal or close family history of seizure disorder - Ferromagnetic material in body or close to head - Neurologic disorder - Pregnancy - Taking medications known to lower seizure threshold (eg, theophylline)

Which medical condition, disease, disorder, syndrome, illness, or injury is researched?

Attention Deficit Hyperactivity Disorder

Study Interventions

Interventions can include giving participants drugs, medical devices, procedures, vaccines, and other products that are either investigational or already available or noninvasive approaches such as surveys, education, and interviews.

Other:methylphenidate tablets and Inter-stimulus Intervals (ISI)We administer 2 single doses of methylphenidate tablets (10mg) separated by a week interval. A paired pulse protocols will be performed with ten single (unconditioned test pulse) and ten paired TMS pulses (conditioning and test pulse) in an intermixed randomized order. Short interval cortical inhibition is measured with an Inter-stimulus Intervals (ISI) of 3 msec and a stimulator output of 80% RMT for the conditioning stimulus and 1mVT stimulation intensity for the test stimulus. ICF investigation is measured with an ISI of 13 msec), with the condition of an ISI of 50 msec (ISI 50) and both stimuli applied with 1mVT intensity). Long Interval Cortical Inhibition (LICI) is measured with ISIs of 100 msec (ISI 100), 200 msec (ISI 200), and 300 msec (ISI 300); both stimuli with 1mVT intensity

Other:methylphenidate tablets and Inter-stimulus Intervals (ISI)We administer 2 single doses of methylphenidate tablets (10mg) separated by a week interval. A paired pulse protocols will be performed with ten single (unconditioned test pulse) and ten paired TMS pulses (conditioning and test pulse) in an intermixed randomized order. Short interval cortical inhibition is measured with an Inter-stimulus Intervals (ISI) of 3 msec and a stimulator output of 80% RMT for the conditioning stimulus and 1mVT stimulation intensity for the test stimulus. ICF investigation is measured with an ISI of 13 msec), with the condition of an ISI of 50 msec (ISI 50) and both stimuli applied with 1mVT intensity). Long Interval Cortical Inhibition (LICI) is measured with ISIs of 100 msec (ISI 100), 200 msec (ISI 200), and 300 msec (ISI 300); both stimuli with 1mVT intensity.

Study Arms

Research studies and clinical trials typically have two or more research arms. An arm is a group of people who receive the same treatment in the study.

methylphenidate tablets (10mg), ADHDFifteen patients of ADHD

methylphenidate tablets, Methamphetamine abusers and ADHDFifteen patients of ADHD with Methamphetamine abuse for at least 2 years plus

Study Status

Unknown status

Start Date: September 2012

Completed Date: March 2016

Phase: N/A

Type: Interventional

Design:

Primary Outcome: Conners ADHD Rating Scale

Secondary Outcome: Change of Motor Evoked Potential (MEP)

Study sponsors, principal investigator, and references

Principal Investigator:

Lead Sponsor: Tehran University of Medical Sciences

Collaborator:

More information:https://clinicaltrials.gov/show/NCT01651169

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