Mechanical Ventilation | Cough Determinants in Mechanically Ventilated Patients
Mechanical Ventilation research study
What is the primary objective of this study?
In our knowledge there is only few data about the cough determinants in mechanically ventilated patients. However some failure of extubation is due to inefficiency cough. In order to determine some determinants of cough, the investigators propose to evaluate systematically different physiological parameters before and after extubation.
Who is eligible to participate?
Inclusion Criteria: - Patients mechanically ventilated since 72h - Age > 18 years - Hospitalized in Intensive care Unit - In weaning phase - with the classically criteria to be extubated - Patients who passed the weaning test (T tube test or other) Exclusion Criteria: - Hemodynamic instability - Absence of consent - No cooperation of the patient - Hemodynamic instability - pH < 7,30 - Severe hypoxemia
Which medical condition, disease, disorder, syndrome, illness, or injury is researched?
Interventions can include giving participants drugs, medical devices, procedures, vaccines, and other products that are either investigational or already available or noninvasive approaches such as surveys, education, and interviews.
Other:Functional respiratory evaluationEach enrolled patients has a pulmonary function test before and after extubation, and repeatedly at D1, D3, D5 (if they are always hospitalized)
Research studies and clinical trials typically have two or more research arms. An arm is a group of people who receive the same treatment in the study.
Start Date: March 2012
Completed Date: December 2015
Primary Outcome: Interest of systematically cough evaluation before extubation
Secondary Outcome: Correlation between success of extubation and respiratory parameters
Study sponsors, principal investigator, and references
Principal Investigator: Nicolas TERZI, MD - PhD
Lead Sponsor: University Hospital, Caen
Collaborator: INSERM U1075,Caen