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Major Depressive Disorder | Can Genetics Predict Treatment Response to a Computerized Self-help Program for Depression?

Major Depressive Disorder research study

What is the primary objective of this study?

The goal of this project is to determine whether genetic information can be used to predict response to an internet-based treatment of depression. Several studies now indicate that completing an internet-based treatment for depression, called Deprexis, can significantly improve symptoms of depression. However, not everyone improves. The purpose of this study is to determine whether genetic profile can predict who is likely to improve.

Who is eligible to participate?

Inclusion Criteria: - English-speaking - Have reliable access to the internet (i.e., dialup or broadband access) - Be willing to donate saliva for DNA research - Have a current symptoms of depression - Be stable on medication and/or therapy (i.e. no changes within 2 weeks of study entry) Exclusion Criteria: - Any diagnosis of a psychotic or bipolar disorder - Meeting for alcohol/drug dependence in the past year - Having current suicidal risk warranting crisis intervention

Which medical condition, disease, disorder, syndrome, illness, or injury is researched?

Major Depressive Disorder

Mood Disorders

Study Interventions

Interventions can include giving participants drugs, medical devices, procedures, vaccines, and other products that are either investigational or already available or noninvasive approaches such as surveys, education, and interviews.

Behavioral:Computerized self-help program for depressionFor 8 weeks, participants will engage in a computerized self-help program for depression, called deprexis. This program consists of 10 content modules representing different psychotherapeutic approaches broadly consistent with a cognitive-behavioral perspective. Modules are organized as simulated dialogues in which the program explains and illustrates concepts and techniques, engages the user in exercises, and continuously asks users to respond by selecting from response options. Subsequent content is then tailored to the users' responses, resulting in a simulated conversational flow. Participants can access the self-help program as often as they would like and since it is self-guided, they will determine how often they access the material. Each module can be completed in 10 to 60 minutes, depending on the user's reading speed, interest, motivation, and individual path through the program.

Study Arms

Research studies and clinical trials typically have two or more research arms. An arm is a group of people who receive the same treatment in the study.

Computerized self-help program for depressionParticipants will have access to a computerized self-help program for depression, called deprexis, for 8 weeks.

Wait List ControlParticipants randomly assigned to a "wait list control" condition will wait 8 weeks after assignment before they can access the deprexis program.

Study Status

Completed

Start Date: March 2013

Completed Date: November 2015

Phase: N/A

Type: Interventional

Design:

Primary Outcome: Quick Inventory of Depressive Symptomatology (Self-Report) (QIDS-SR-16)

Secondary Outcome: Hamilton Depression Rating Scale (HAM-D)

Study sponsors, principal investigator, and references

Principal Investigator: Christopher G Beevers, PhD

Lead Sponsor: University of Texas at Austin

Collaborator: Brown University

More information:https://clinicaltrials.gov/show/NCT01818453

Discuss Depression