Major Depressive Disorder | Cognitive Behavior Therapy for Depression Depression
Major Depressive Disorder research study
What is the primary objective of this study?
Psychological mindedness(PM) is a meta cognitive process in which the person uses his cognitive and affective abilities to better understand his thoughts, feelings, and his behaviors as they interact with his internal experiences and his external experiences in the world, and dynamically modifies his behavior to move towards self actualization, in a manner positive to himself and the world. We investigate whether assessment of PM can distinguish depressed patients who benefit from CBT.
Who is eligible to participate?
Inclusion Criteria: - Males or females between the ages of 18 and 70 (inclusive). - Primary DSM-IV-TR diagnosis of major depression - A negative urine toxicology, i.e., a urine specimen that does not test positive for use of drugs of abuse, or use of benzodiazepines. - Ability to give informed consent. - Fluent in English Exclusion Criteria: - Patients who have a \"lifetime\" history of Schizophrenia or other current psychotic disorder, Major Depressive Disorder with Psychotic or Catatonic features, Bipolar I Affective Disorder or Organic Mental Disease. - DSM-V substance abuse or dependence within the past 6 months (except nicotine or caffeine). - Active suicidal or homicidal ideation, or judged to be at serious suicide risk. - Any unstable medical or neurological condition. - Presently receiving psychotherapy. - Prior History of CBT for Depression treatment failure.
Which medical condition, disease, disorder, syndrome, illness, or injury is researched?
Major Depressive Disorder
Interventions can include giving participants drugs, medical devices, procedures, vaccines, and other products that are either investigational or already available or noninvasive approaches such as surveys, education, and interviews.
Behavioral:Cognitive Behavior TherapyFourteen sessions of cognitive behavior therapy for depression. The patient will be psycho educated about symptoms of depression. The patient will learn to use the following basic cognitive-behavioral techniques for the treatment of depression: Constructing an 'Action Schedule', setting goals, doing 'Behavioral Experiments', and constructing a thought record, checking accuracy of thoughts, re framing thoughts when necessary and learn to engage in problem solving for particular situations.
Research studies and clinical trials typically have two or more research arms. An arm is a group of people who receive the same treatment in the study.
*Cognitive behavior therapy *TherapyDepressed patient will receive 14 sessions of cognitive behavior therapy (CBT) for depression. Includes behavior activation, correcting distorted thoughts, and other tools to reduce symptoms
Start Date: July 2009
Completed Date: August 2019
Primary Outcome: Level of depression as measured by the Hamilton Depression Rating Scale
Study sponsors, principal investigator, and references
Principal Investigator: Ronit Kishon, Ph.D.
Lead Sponsor: New York State Psychiatric Institute