Dementia With Lewy Bodies | Imaging of Vesicular Acetylcholine and Dopamine Transporters in Dementia With Lewy Bodies
Dementia With Lewy Bodies research study
What is the primary objective of this study?
The general aim of this research project is to determine the relationships between alterations of central cholinergic (ACh) and dopaminergic (DA) systems and neurobehavioral features of dementias with Lewy bodies (DLB). Both clinical and neurochemical data support the view that DLB is not a homogeneous entity and it can be hypothesized that differential alterations of central ACh systems (i.e. anterior vs posterior vs striatal interneurons) in association or not with a DA nigrostriatal dysfunction could partly support the clinical heterogeneity observed in this disease. ACh in vivo imaging has been relatively underutilized to date and to our knowledge only on the postsynaptic side. Furthermore, ACh/DA interactions and their relationships with the symptomatology of DLB and related pathologies (PDD) had never been investigated.
Who is eligible to participate?
Inclusion Criteria: - Patients: man or woman probable DLB, with and without extrapyramida syndrome - Healthy subjects: man or woman with no neuropsychiatric disorders Exclusion Criteria: - Diagnostic or therapeutic irradiation during the 12 months before SPECT imaging - Age less than 18 and more than 90 - Iodine sensibility - Brain-vascular disease, severe brain injury, type I and II diabetes mellitus, thyroid dysfunction, chronic alcoholism - Pregnant and breast feeding women, women in age to procreate - Impossibility to undergo MRI study (pace-maker, claustrophobia) - Persons under guardianship, outside state to express their assent or in emergency situation - Healthy subjects: cognitive impairment, dementia
Which medical condition, disease, disorder, syndrome, illness, or injury is researched?
Dementia With Lewy Bodies
Interventions can include giving participants drugs, medical devices, procedures, vaccines, and other products that are either investigational or already available or noninvasive approaches such as surveys, education, and interviews.
Other:Imaging with IBVMin vivo molecular imaging of presynaptic molecular target of cholinergic systems with [123I]-iodobenzovesamicol
Other:Imaging with DATSCANin vivo molecular imaging of presynaptic molecular target of dopaminergic systems (DAT) with DATSCAN
Behavioral:neuropsychological evaluationneuropsychological evaluation using neuropsychological tests
Research studies and clinical trials typically have two or more research arms. An arm is a group of people who receive the same treatment in the study.
DLB with extrapyramidal syndromepatients dementia with Lewy bodies with extrapyramidal syndrome
DLB without extrapyramidal syndromepatients dementia with Lewy bodies without extrapyramidal syndrome
healthy volunteershealthy volunteers
Start Date: May 2009
Completed Date: October 2013
Primary Outcome: Binding Potential (BP) quantification of each radioligand
Secondary Outcome: Ratio dopaminergic system/cholinergic system Binding Potential
Study sponsors, principal investigator, and references
Principal Investigator: Michèle ALLARD, Pr
Lead Sponsor: University Hospital, Bordeaux